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chr16:29,905,882-31,860,399

Best TWAS P=4.39e-10 · Best GWAS P=4.71e-09 conditioned to 0.896

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Cells Transformed fibroblasts	RNF40	0.08	0.04	lasso	8	0.04	5.6e-04	5.7	6.2	4.4e-10	0.93	0.02	0.97	TRUE
14	GTEx	Thyroid	RNF40	0.07	0.03	lasso	3	0.03	1.5e-03	5.6	5.9	2.9e-09	0.89	0.02	0.96	FALSE
5	GTEx	Brain Cerebellum	RNF40	0.24	0.16	lasso	5	0.13	9.7e-05	5.6	5.9	4.2e-09	0.78	0.02	0.94	FALSE
15	GTEx	Thyroid	C16orf93	0.17	0.18	lasso	4	0.18	1.6e-13	5.7	-5.8	5.3e-09	-0.75	0.02	0.98	FALSE
8	GTEx	Esophagus Muscularis	RNF40	0.16	0.10	lasso	1	0.08	1.3e-05	5.8	5.8	7.7e-09	0.70	0.01	0.97	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNF40	0.07	0.11	lasso	5	0.10	7.5e-11	5.8	5.8	7.8e-09	0.71	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf93	0.15	0.19	lasso	4	0.19	1.8e-18	5.8	-5.8	8.5e-09	-0.71	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RNF40	0.14	0.15	enet	7	0.15	1.9e-17	5.7	5.8	8.9e-09	0.69	0.02	0.98	FALSE
16	METSIM	Adipose	RNF40	0.12	0.07	lasso	4	0.07	1.1e-10	5.6	5.7	9.5e-09	0.74	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	STX4	0.06	0.05	lasso	2	0.02	7.8e-03	5.6	5.7	1.1e-08	0.75	0.03	0.88	FALSE
3	GTEx	Adipose Subcutaneous	RNF40	0.18	0.10	lasso	7	0.11	3.7e-09	5.8	5.6	1.8e-08	0.71	0.02	0.98	FALSE
12	GTEx	Testis	C16orf93	0.10	0.09	lasso	3	0.08	1.4e-04	5.8	-5.6	2.1e-08	-0.70	0.02	0.96	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf93	0.02	0.02	blup	11	0.02	1.5e-03	5.8	-5.6	2.1e-08	-0.70	0.00	0.71	FALSE
9	GTEx	Nerve Tibial	RNF40	0.13	0.08	lasso	5	0.09	8.1e-07	5.6	5.6	2.3e-08	0.67	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf93	0.14	0.11	blup	10	0.11	4.5e-07	5.8	-5.5	3.8e-08	-0.70	0.00	1.00	FALSE
7	GTEx	Colon Transverse	STX1B	0.12	0.01	lasso	5	0.00	3.9e-01	5.6	5.4	5.1e-08	0.84	0.05	0.33	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	RNF40	0.19	0.14	bslmm	201	0.15	2.7e-18	5.6	5.4	7.5e-08	0.54	0.02	0.98	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	C16orf93	0.19	0.26	lasso	10	0.28	5.1e-36	5.6	-5.4	7.7e-08	-0.72	0.02	0.98	FALSE
10	GTEx	Ovary	STX4	0.16	0.05	enet	13	0.07	9.0e-03	4.1	5.4	8.3e-08	0.86	0.06	0.52	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf93	0.09	0.09	blup	11	0.09	1.0e-10	5.6	-5.4	8.3e-08	-0.68	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	RNF40	0.09	0.08	blup	12	0.07	2.1e-08	5.8	5.3	9.6e-08	0.64	0.00	1.00	FALSE
13	GTEx	Thyroid	HSD3B7	0.27	0.12	lasso	4	0.17	7.0e-13	3.7	5.2	1.6e-07	0.81	0.06	0.94	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RNF40	0.06	0.02	enet	4	0.03	6.0e-04	5.8	5.2	1.9e-07	0.62	0.00	0.86	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	4.4	5.2	2.0e-07	0.89	0.04	0.82	FALSE
11	GTEx	Skin Sun Exposed Lower leg	STX4	0.04	0.02	enet	18	0.04	3.9e-04	3.2	5.2	2.5e-07	0.72	0.26	0.42	FALSE
4	GTEx	Brain Caudate basal ganglia	PRSS36	0.16	0.25	lasso	3	0.23	2.4e-07	5.0	5.1	2.9e-07	0.85	0.15	0.63	FALSE
19	YFS	Blood	ZNF785	0.05	0.07	lasso	4	0.06	2.0e-20	4.7	5.1	2.9e-07	0.66	0.74	0.26	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	RNF40	0.06	0.04	blup	12	0.06	3.6e-06	5.8	5.1	2.9e-07	0.58	0.00	0.99	FALSE