TWAS hub - C16orf93

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.2520	0.1167	6.0e-04	0.134	NA	0.231	NA	0.219	2.1e-04	NA	8.3e-07	NA	1.8e-06
2	GTEx	Brain Nucleus accumbens basal ganglia	0.3020	0.1370	8.9e-03	0.001	NA	0.002	NA	0.009	3.0e-01	NA	2.8e-01	NA	1.8e-01
3	GTEx	Muscle Skeletal	0.2146	0.0660	2.9e-04	0.004	NA	0.008	NA	0.002	1.1e-01	NA	5.0e-02	NA	2.0e-01
4	GTEx	Ovary	0.1300	0.0670	3.5e-03	0.065	NA	0.078	NA	0.089	1.1e-02	NA	5.8e-03	NA	3.4e-03
5	GTEx	Pituitary	0.0970	0.0540	1.0e-02	0.000	NA	0.005	NA	-0.010	3.2e-01	NA	2.4e-01	NA	6.6e-01
6	GTEx	Testis	0.1020	0.0500	2.4e-03	0.086	NA	0.076	NA	0.084	1.2e-04	NA	2.9e-04	NA	1.4e-04
7	GTEx	Thyroid	0.1700	0.0540	1.8e-09	0.177	NA	0.174	NA	0.177	1.5e-13	NA	2.5e-13	NA	1.6e-13
8	GTEx	Uterus	0.2270	0.1070	6.4e-03	-0.001	NA	-0.007	NA	0.059	3.3e-01	NA	4.8e-01	NA	2.5e-02
9	ROSMAP	Brain Pre-frontal Cortex	0.1889	0.0380	0.0e+00	0.260	0.261	0.278	0.268	0.279	3.1e-33	2.0e-33	6.8e-36	2.1e-34	5.1e-36
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0161	0.0118	9.8e-03	0.019	0.022	0.019	NA	0.017	2.9e-03	1.5e-03	3.1e-03	NA	4.4e-03
11	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1430	0.0890	1.5e-07	0.112	0.114	0.096	NA	0.097	6.3e-07	4.5e-07	4.0e-06	NA	3.3e-06
12	TCGA	Brain Lower Grade Glioma	0.0930	0.0539	2.0e-09	0.089	0.093	0.090	NA	0.085	2.9e-10	1.0e-10	2.0e-10	NA	7.3e-10
13	TCGA	Thyroid Carcinoma	0.1530	0.0920	5.6e-17	0.192	0.179	0.191	NA	0.193	2.2e-18	4.0e-17	2.4e-18	NA	1.8e-18

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8	9	10	11	12	13
Alzheimer’s Disease (including proxy)	11.9	17.2	32.1	4.6	3.6	4.7	5.7	4.1	3.7	3.3	4.2	4.2	4.4	4.8	4.0
Comparative body size at age 10	10.5	29.0	58.4	-5.9	-5.3	-5.8	-7.6	-6.5	-5.4	-5.1	-5.5	-4.6	-5.0	-4.5	-5.2
Waist circumference	10.3	37.7	97.6	-7.0	-5.4	-6.8	-9.9	-5.6	-5.3	-5.9	-6.2	-5.4	-6.2	-6.4	-5.2
Diastolic blood pressure, automated reading	9.7	30.1	52.5	-6.0	-4.1	-5.8	-5.4	-5.6	-5.5	-3.7	-5.9	-6.3	-6.4	-7.2	-5.6
Hip circumference	9.5	41.0	116.6	-7.4	-6.5	-7.7	-10.8	-5.7	-5.1	-6.8	-6.4	-4.8	-5.9	-5.5	-5.0
Arm fat mass (left)	8.9	36.5	90.4	-6.7	-6.1	-6.9	-9.5	-5.4	-4.9	-6.6	-6.1	-5.1	-6.0	-5.9	-5.0
Alcohol intake frequency.	8.6	20.0	49.7	-4.5	-3.2	-3.9	-7.0	-4.5	-4.0	-3.5	-4.6	-4.6	-5.0	-5.6	-4.2
Arm fat percentage (left)	8.5	34.1	82.8	-6.6	-6.2	-6.7	-9.1	-5.2	-5.0	-6.0	-5.9	-4.9	-5.8	-5.4	-5.0
Arm fat mass (right)	8.3	34.3	88.5	-6.5	-5.9	-6.5	-9.4	-5.3	-4.7	-6.2	-5.9	-4.9	-5.8	-5.8	-4.8
Leg fat mass (left)	8.1	31.8	85.0	-7.0	-5.3	-6.5	-9.2	-5.0	-4.6	-5.5	-5.7	-4.5	-5.5	-5.3	-4.5
Alzheimer’s Disease (in mother)	7.9	9.2	16.7	2.9	3.4	2.8	4.1	2.7	2.6	3.0	3.0	3.2	3.4	3.7	2.9
Body mass index (BMI)	7.9	33.9	89.5	-6.9	-6.0	-6.3	-9.5	-5.2	-4.4	-6.2	-5.9	-4.6	-5.8	-5.6	-4.5
Weight	7.8	38.4	96.4	-6.3	-5.8	-6.8	-9.8	-5.7	-5.1	-6.5	-6.3	-5.6	-6.3	-6.8	-5.1
Arm fat percentage (right)	7.8	30.9	77.3	-6.3	-5.8	-6.4	-8.8	-5.0	-4.7	-5.6	-5.6	-4.6	-5.5	-5.1	-4.7
Leg fat mass (right)	7.7	29.8	78.5	-6.6	-5.1	-6.4	-8.9	-5.0	-4.5	-5.3	-5.5	-4.4	-5.3	-5.1	-4.5
Medication: Bendroflumethiazide	7.7	11.6	23.2	-3.7	-1.9	-3.4	-3.8	-3.2	-3.0	-2.8	-4.0	-3.8	-4.1	-4.8	-3.2
Whole body fat mass	7.5	31.4	83.7	-6.4	-5.7	-6.5	-9.2	-4.9	-4.7	-5.5	-5.6	-4.7	-5.5	-5.4	-4.6
Medication: Atorvastatin	7.2	8.9	14.3	-3.5	-1.3	-3.4	-2.5	-2.6	-3.6	-2.2	-3.8	-3.1	-3.7	-3.1	-3.6
Trunk fat mass	7.0	30.3	79.0	-6.1	-5.5	-6.5	-8.9	-4.8	-4.8	-5.3	-5.5	-4.7	-5.4	-5.3	-4.7
Body fat percentage	7.0	27.6	75.5	-6.5	-5.5	-6.4	-8.7	-4.5	-4.6	-4.6	-5.2	-4.1	-5.0	-4.4	-4.4
Triglycerides	6.9	11.2	17.6	-4.1	-4.1	-4.0	-4.2	-2.8	-3.1	-2.9	-3.6	-2.9	-3.4	-3.5	-2.8
Pulse rate, automated reading	6.9	22.2	34.1	-3.1	-2.7	-5.0	-4.2	-5.6	-5.8	-3.4	-5.4	-5.6	-5.5	-5.4	-5.8
Leg fat percentage (left)	6.9	25.1	70.6	-7.0	-5.1	-6.0	-8.4	-4.4	-4.1	-4.2	-5.0	-3.6	-4.6	-4.0	-4.0
Primary Biliary Cirrhosis	6.7	9.5	16.0	-3.0	-4.0	-2.4	-3.3	-3.5	-3.0	-3.5	-3.0	-3.1	-3.1	-3.4	-2.8
Rheumatoid Arthritis	6.7	9.3	13.1	-3.1	-3.0	-1.7	-3.1	-3.1	-3.2	-3.1	-3.5	-3.4	-3.5	-3.6	-3.3
Trunk fat percentage	6.5	25.9	68.6	-6.0	-5.3	-6.2	-8.3	-4.3	-4.6	-4.5	-5.1	-4.1	-4.8	-4.4	-4.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.5	13.7	39.2	5.4	2.7	5.3	6.3	3.5	2.9	2.8	3.6	2.5	3.3	2.7	2.9
Blood White Count	6.3	47.0	92.9	7.8	7.5	5.1	9.6	8.2	6.5	6.1	7.5	6.5	7.1	6.2	6.5
High blood pressure	6.1	17.1	28.9	-4.7	-3.3	-4.2	-4.6	-3.8	-4.0	-3.1	-4.6	-4.5	-4.9	-5.4	-4.0
BMI	5.8	33.7	96.0	-7.3	-6.4	-6.4	-9.8	-4.9	-4.0	-6.2	-5.6	-4.4	-5.6	-5.3	-4.1
Leg fat percentage (right)	5.7	20.8	60.3	-6.4	-4.7	-5.6	-7.8	-4.1	-3.7	-3.6	-4.4	-3.1	-4.1	-3.3	-3.6
Hypertension (Self-reported)	5.7	15.8	26.1	-4.5	-3.3	-4.2	-4.5	-3.8	-3.8	-2.9	-4.3	-4.2	-4.7	-5.1	-3.8
Lung FEV1/FVC ratio	5.5	27.7	52.3	5.6	4.6	4.5	6.3	4.8	5.3	7.2	5.6	5.2	5.5	5.3	5.2
Suffer from ‘nerves’	5.5	8.6	18.0	2.9	1.0	3.5	4.2	2.6	2.5	3.2	3.1	3.1	3.0	3.8	2.5
Vascular/heart problems diagnosed by doctor	5.5	15.1	25.0	4.6	3.3	4.3	4.5	3.5	3.7	2.5	4.4	4.0	4.6	5.0	3.6
Blood Red Count	5.4	52.2	166.4	7.6	8.1	9.2	9.6	7.2	6.2	12.9	6.2	4.0	4.8	4.0	5.6
Frequency of tenseness / restlessness in last 2 weeks	5.3	8.3	17.6	3.3	2.4	2.8	4.2	3.1	2.8	3.1	3.1	2.6	2.7	2.7	2.7
Asthma (self-reported)	5.2	10.3	22.8	-1.9	-3.1	-3.5	-3.0	-3.5	-3.8	-4.8	-3.5	-3.0	-3.3	-2.1	-3.8
Asthma	5.1	10.0	21.3	-2.1	-2.9	-3.6	-2.9	-3.5	-3.7	-4.6	-3.4	-2.9	-3.2	-2.0	-3.7
Cardiovascular Disease	5.0	16.5	25.3	-5.0	-3.8	-5.0	-4.7	-3.5	-3.8	-3.0	-4.5	-3.9	-4.6	-4.7	-3.7
Respiratory disease	5.0	11.2	21.4	-2.8	-3.3	-3.2	-3.7	-2.9	-3.5	-4.6	-3.6	-3.2	-3.5	-3.4	-3.5
Number of treatments/medications taken	4.9	8.8	13.8	-3.7	-2.7	-3.5	-3.7	-3.6	-3.1	-2.0	-2.8	-2.7	-3.1	-2.6	-3.0
Nervous feelings	4.9	9.2	26.0	4.4	0.7	4.1	5.1	2.7	2.4	2.5	3.2	2.5	2.8	2.9	2.4
Leg fat-free mass (right)	4.9	26.1	49.7	-3.8	-4.4	-5.0	-7.0	-4.8	-4.2	-6.5	-5.2	-5.2	-5.6	-6.7	-4.4
Leg predicted mass (right)	4.9	26.2	50.1	-3.8	-4.4	-5.0	-7.1	-4.8	-4.2	-6.4	-5.2	-5.2	-5.6	-6.7	-4.4
Leg fat-free mass (left)	4.8	25.3	50.3	-4.0	-4.4	-5.0	-7.1	-4.8	-4.1	-6.3	-5.2	-5.0	-5.4	-6.3	-4.3
Number of incorrect matches in round	4.8	8.0	17.7	3.1	2.9	3.1	4.2	2.5	2.0	4.0	2.8	2.1	2.8	2.4	2.3
Medication: Blood pressure	4.8	9.1	13.3	-3.6	-2.6	-3.4	-3.6	-3.1	-2.6	-3.0	-3.0	-3.0	-3.4	-3.5	-2.8
Hand grip strength (left)	4.7	12.3	20.7	-3.9	-4.2	-4.4	-4.5	-3.3	-2.8	-4.4	-3.5	-2.8	-3.3	-3.0	-3.0
Leg predicted mass (left)	4.7	24.7	49.8	-3.9	-4.4	-5.0	-7.1	-4.7	-4.0	-6.2	-5.0	-4.9	-5.3	-6.2	-4.2
Pain experienced in last month	4.6	7.7	14.0	3.5	3.7	3.4	3.5	3.2	2.7	2.3	2.6	2.0	2.6	1.6	2.6
Hand grip strength (right)	4.5	12.1	19.1	-3.6	-3.5	-4.1	-3.9	-3.4	-3.1	-4.4	-3.7	-3.3	-3.5	-3.4	-3.3
Illnesses of siblings	4.4	6.1	15.3	3.3	2.6	3.0	3.9	2.0	2.4	1.3	2.3	2.0	2.6	2.2	2.3
Wheeze or whistling in the chest in last year	4.4	7.9	16.8	-1.7	-4.1	-3.5	-3.6	-2.4	-2.6	-3.7	-2.8	-2.2	-2.8	-2.2	-2.5
Tinnitus: Yes, but not now, but have in the past	4.3	4.6	7.7	-1.6	-1.7	-1.9	-1.8	-2.3	-2.8	-1.8	-2.5	-2.5	-2.5	-2.4	-2.6
Basal metabolic rate	4.3	23.7	52.9	-4.1	-4.2	-5.0	-7.3	-4.6	-3.8	-5.8	-5.0	-4.7	-5.2	-6.1	-4.0
Cholesterol lowering medication	4.3	6.4	15.7	-3.9	-1.9	-3.5	-4.0	-2.9	-2.2	-0.8	-2.5	-1.6	-2.4	-1.4	-2.2
Pain all over the body in last month	4.2	4.5	8.9	-2.3	-0.9	-3.0	-2.3	-2.1	-2.6	-1.2	-2.7	-2.0	-2.3	-1.9	-2.4
High cholesterol (Self-reported)	4.2	7.5	18.7	-4.3	-1.6	-3.8	-3.4	-2.5	-2.9	-1.3	-3.1	-2.1	-2.9	-2.0	-2.8
HbA1C	4.0	4.4	10.3	-3.2	-3.0	-1.4	-2.4	-2.2	-1.8	-2.7	-2.0	-1.5	-1.9	-1.2	-2.1
Blood Eosinophil Count	4.0	30.8	43.0	6.5	3.9	4.0	5.1	6.1	5.3	6.4	6.3	6.5	6.4	6.6	5.4
High blood pressure (siblings)	4.0	5.8	17.0	-4.1	-2.4	-3.1	-3.4	-1.5	-2.0	-0.9	-2.0	-1.9	-2.5	-2.3	-2.0
Irritability	4.0	6.7	16.3	3.2	2.0	4.0	4.0	3.0	2.7	1.3	3.2	1.3	1.9	0.2	2.7
Arm predicted mass (right)	3.9	19.7	44.8	-4.3	-3.4	-4.7	-6.7	-4.2	-3.5	-5.1	-4.5	-4.3	-4.7	-5.5	-3.6
Overall health rating	3.9	8.4	19.4	-3.7	-2.2	-3.0	-4.4	-3.1	-2.8	-1.4	-2.9	-2.6	-3.4	-2.7	-2.9
Medication for cholesterol	3.8	5.8	14.1	3.4	2.5	3.1	3.7	2.5	2.0	1.3	2.3	1.8	2.4	1.8	2.1
Arm fat-free mass (right)	3.7	18.8	45.2	-4.2	-3.5	-4.5	-6.7	-4.1	-3.2	-5.0	-4.4	-4.1	-4.6	-5.3	-3.4
Number of self-reported non-cancer illnesses	3.7	6.5	16.2	-4.0	-2.1	-2.7	-2.7	-2.5	-2.8	-1.5	-2.8	-2.4	-2.7	-2.3	-2.6
Worry (Nagel 2018)	3.6	7.7	28.4	5.1	1.0	4.4	5.3	2.2	1.7	1.5	2.2	1.5	1.8	1.7	1.5
Heel T-Score	3.6	28.6	44.4	4.9	3.6	6.0	6.7	5.0	5.2	5.6	6.1	5.6	6.2	5.9	5.4
Financial difficulties in last 2 years	3.6	4.8	10.8	-1.8	-1.3	-2.6	-2.5	-1.7	-1.9	-0.9	-2.6	-2.5	-2.9	-3.3	-2.1
Alzheimer’s Disease (in father)	3.5	3.8	5.7	2.3	0.9	2.4	2.3	2.1	2.0	1.5	2.0	2.1	2.1	2.3	1.9
Tense / ‘highly strung’	3.4	5.6	18.0	3.5	1.2	3.9	4.2	2.2	1.7	2.0	2.5	1.1	1.8	0.9	1.7
Arm predicted mass (left)	3.4	17.3	46.0	-4.0	-3.3	-4.7	-6.8	-3.8	-3.0	-4.7	-4.3	-3.7	-4.3	-4.9	-3.2
Impedance of leg (right)	3.3	15.9	33.6	3.1	4.1	3.0	5.6	3.6	2.7	5.8	4.0	3.8	4.4	5.2	3.1
Illnesses of father: Heart disease	3.3	4.5	8.0	0.6	1.6	1.1	1.0	2.5	2.7	2.3	2.2	2.8	2.5	2.8	2.7
Arm fat-free mass (left)	3.3	16.7	41.6	-3.9	-3.4	-4.4	-6.5	-3.9	-3.0	-4.7	-4.1	-3.8	-4.3	-4.9	-3.1
Worrier / anxious feelings	3.2	6.0	19.6	4.4	1.0	4.0	4.2	2.0	2.0	0.7	2.1	1.5	1.8	1.6	1.8
Whole body fat-free mass	3.2	18.3	39.1	-3.2	-3.4	-4.2	-6.2	-4.1	-3.3	-5.3	-4.4	-4.3	-4.6	-5.6	-3.5
Breastfed as a baby	3.1	3.8	6.7	-1.5	-1.1	-2.0	-1.8	-2.2	-2.6	-1.6	-2.0	-2.4	-2.3	-2.1	-2.5
Whole body water mass	3.1	17.9	38.4	-3.2	-3.5	-4.2	-6.2	-4.1	-3.2	-5.3	-4.3	-4.2	-4.6	-5.5	-3.4
Falls in the last year	3.0	4.0	15.2	-3.9	-1.5	-2.8	-3.0	-1.7	-1.9	-0.6	-1.7	-1.3	-1.6	-0.9	-1.7
Birth weight of first child	3.0	5.5	13.8	-2.3	-3.7	-2.8	-3.2	-2.2	-2.2	-2.4	-2.2	-1.8	-2.0	-1.8	-2.0
Pulse wave Arterial Stiffness index	2.9	3.4	5.6	-1.4	-1.5	-1.9	-1.7	-2.1	-1.8	-1.4	-2.4	-2.1	-2.2	-2.2	-2.0
Medication: Ventolin 100micrograms inhaler	2.9	3.8	10.3	-0.5	-1.9	-1.6	-1.5	-2.0	-2.1	-3.2	-1.7	-2.2	-2.1	-2.2	-2.1
Blood Platelet Count	2.7	31.2	53.0	3.5	3.0	3.5	3.9	7.1	7.1	5.3	6.7	7.3	6.6	6.1	7.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.6	33.5	5.8	1.7	4.7	5.1	2.3	2.0	1.7	2.7	0.7	1.9	0.1	1.9
Medication: Paracetamol	2.7	4.4	20.3	-2.6	-4.5	-2.2	-2.9	-1.9	-1.5	-1.0	-1.3	-1.3	-1.8	-1.4	-1.5
Mouth/teeth dental problems: Mouth ulcers	2.7	4.2	8.6	1.6	-0.8	0.9	-0.0	2.5	2.7	1.5	2.5	2.9	2.5	2.5	2.9
Impedance of leg (left)	2.5	12.3	29.1	2.4	3.9	2.7	4.9	3.4	2.2	5.4	3.4	3.2	3.8	4.3	2.7
Pulse wave peak to peak time	2.5	2.9	4.8	1.6	1.4	1.8	1.6	2.0	1.7	1.1	2.2	1.8	2.1	1.9	1.9
Average weekly champagne plus white wine intake	2.5	3.4	7.1	0.6	0.7	1.1	1.7	1.8	1.9	2.2	2.1	2.5	2.2	2.7	2.1
Myopia	2.5	3.6	7.9	-1.5	-2.8	-2.3	-2.8	-1.8	-2.0	-0.8	-1.7	-1.6	-1.9	-1.6	-1.9
Commuting to job workplace: Car/motor vehicle	2.4	2.7	4.6	1.4	1.3	1.3	1.8	2.0	2.2	1.1	1.7	1.9	1.8	1.8	2.0
Unable to work because of sickness or disability	2.4	3.1	5.5	-1.9	-1.2	-2.2	-2.3	-1.8	-1.6	-1.1	-2.0	-1.7	-2.0	-2.3	-1.5
Medication: Co-codamol	2.3	2.6	5.7	-2.3	-1.5	-1.5	-2.4	-1.4	-1.1	-1.9	-1.9	-1.3	-1.6	-1.6	-1.2
Townsend deprivation index at recruitment	2.3	3.3	4.9	-1.8	-1.4	-2.2	-1.9	-2.1	-1.9	-1.0	-1.9	-1.9	-2.2	-1.9	-2.0
Headache pain in last month	2.3	4.0	11.1	-2.2	-3.3	-1.8	-2.3	-2.1	-2.0	-2.4	-1.5	-1.4	-1.8	-1.0	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	8.5	2.3	2.9	1.4	2.6	1.3	1.2	2.6	1.2	1.0	1.3	1.0	1.3
Back pain experienced in last month	2.3	3.3	5.7	-1.4	-2.2	-1.3	-1.6	-2.4	-2.1	-2.2	-1.5	-1.9	-2.0	-1.7	-2.1
Type 2 Diabetes (T2D) (2018)	2.2	4.2	7.9	-2.8	-0.5	-2.5	-2.8	-1.6	-2.0	-1.6	-1.9	-2.1	-2.5	-2.1	-2.1
Supplements: Glucosamine	2.2	2.9	5.7	0.6	0.6	1.4	-0.1	1.6	2.2	1.3	2.0	2.3	2.4	2.3	2.4
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	10.8	2.1	2.2	2.2	3.3	2.1	2.2	1.8	2.4	2.1	2.5	2.3	2.3
Emphysema/chronic bronchitis	2.2	2.4	7.8	-0.9	-2.8	-1.5	-1.3	-1.0	-1.4	-1.8	-1.3	-1.6	-1.6	-2.0	-1.2
Breast cancer (self-reported)	2.2	2.7	4.9	-0.6	-1.8	-1.6	-1.1	-1.6	-2.2	-1.9	-2.0	-1.8	-1.7	-1.6	-1.9
Illnesses of father: None of the above (group 1)	2.2	2.7	8.2	1.5	-0.2	0.3	0.0	-1.8	-1.9	-1.6	-1.5	-2.5	-1.8	-2.9	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	8.0	2.2	1.5	1.8	2.8	2.1	2.2	1.9	2.2	2.5	2.6	2.8	2.3
Medication: Ramipril	2.1	2.7	5.2	-2.3	-0.5	-1.8	-2.0	-1.5	-1.9	-1.1	-1.8	-1.6	-2.0	-1.8	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	8.5	-0.7	-2.1	0.3	-1.2	-1.4	-1.6	-2.9	-0.9	-1.8	-1.6	-1.9	-1.5
Smoking status: Previous	2.1	3.2	6.2	-0.3	1.6	-0.3	2.0	1.8	2.2	1.4	2.2	2.3	2.0	2.5	2.0
Ever smoked	2.1	3.6	6.9	0.7	1.7	0.5	1.4	2.1	2.6	1.9	2.5	2.3	2.1	2.1	2.5
Lupus	2.0	3.0	8.9	-0.0	-3.0	-0.7	-1.0	-2.3	-2.3	-1.6	-1.4	-1.9	-1.7	-1.4	-2.2
Chronic bronchitis/emphysema (mother)	2.0	2.4	8.5	-1.5	-2.9	-1.8	-1.8	-2.1	-1.4	-1.7	-1.2	-0.7	-1.0	-0.2	-1.3
Qualifications: College or University degree	2.0	6.4	15.9	4.0	2.8	1.9	3.7	1.8	1.7	1.9	2.2	2.3	2.8	3.3	1.8
Neck or shoulder pain in last month	2.0	2.8	7.5	-2.7	-2.4	-1.4	-2.2	-2.0	-1.0	-1.3	-1.3	-1.3	-1.5	-1.8	-1.0
Supplements: Fish oil (including cod liver oil)	2.0	2.6	4.1	0.6	1.6	1.9	1.0	1.4	1.9	1.7	2.0	1.9	1.8	1.9	1.8
Past tobacco smoking	1.9	3.6	6.6	0.2	-1.7	0.1	-1.8	-2.0	-2.6	-1.6	-2.4	-2.4	-2.1	-2.2	-2.4
Trunk fat-free mass	1.9	11.2	26.7	-2.3	-2.4	-3.2	-5.2	-3.3	-2.3	-4.1	-3.4	-3.4	-3.6	-4.6	-2.5
Pulse rate	1.9	3.3	5.7	-1.2	-0.9	-1.7	-1.2	-2.3	-2.4	-0.9	-1.9	-2.3	-2.1	-2.3	-2.3
Trunk predicted mass	1.9	10.9	26.3	-2.2	-2.3	-3.2	-5.1	-3.3	-2.3	-4.1	-3.4	-3.4	-3.5	-4.6	-2.5
Medication for pain relief, constipation, heartburn	1.9	3.2	10.5	2.5	3.2	1.9	2.7	2.0	1.4	0.9	1.1	1.1	1.5	1.1	1.3
Medication: Paracetamol	1.9	3.0	14.7	-2.2	-3.8	-1.8	-2.7	-1.7	-1.1	-0.3	-0.8	-0.9	-1.2	-0.8	-1.1
Had other major operations	1.8	2.2	8.2	-2.1	-2.9	-1.2	-1.5	-1.4	-1.0	-0.5	-1.1	-1.4	-1.3	-1.9	-0.8
Lung cancer (father)	1.8	2.1	8.9	-0.1	-1.8	-0.2	-0.6	-1.0	-1.4	-0.7	-1.1	-2.2	-1.8	-3.0	-1.4
Knee pain experienced in last month	1.8	2.9	13.5	-1.5	-3.7	-2.8	-2.4	-1.5	-0.7	-1.4	-0.9	-0.5	-1.1	-0.9	-0.6
Neuroticism (Nagel 2018)	1.7	4.1	15.9	3.5	0.0	4.0	4.0	2.0	1.1	-0.2	1.6	0.3	0.7	-0.2	0.9
Crohns Disease (2012)	1.7	2.8	5.5	1.2	-0.9	2.2	0.8	2.3	1.8	1.3	2.1	1.8	2.0	1.4	2.1
Diabetes (mother)	1.7	2.1	7.6	-2.8	-0.9	-0.7	-2.6	-1.2	-1.0	-0.7	-1.2	-1.2	-1.6	-1.5	-1.1
Sitting height	1.7	12.2	17.6	4.2	3.9	3.1	2.9	3.6	3.8	4.2	3.8	3.4	3.6	3.1	3.8
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.5	0.4	1.6	1.2	1.5	1.7	1.4	1.9	1.5	1.4	1.6	1.1	1.6
Number of operations (self-reported)	1.7	2.5	7.4	-2.7	-0.8	-1.7	-1.5	-1.6	-1.4	-1.0	-1.7	-1.6	-1.9	-1.9	-1.4
Impedance of whole body	1.7	8.8	24.4	3.1	3.2	2.2	4.9	2.8	1.3	4.2	2.9	2.2	3.1	3.5	1.7
Crohns Disease (2017)	1.6	3.5	8.9	1.3	0.3	3.0	2.2	2.5	2.1	2.6	2.1	1.2	1.3	0.1	2.2
Lung FVC	1.6	8.2	35.4	5.0	1.5	5.3	6.0	1.6	1.4	1.1	2.4	0.2	1.3	1.0	1.1
Hearing difficulty/problems: Yes	1.6	2.5	10.0	-3.1	-2.2	-1.7	-3.2	-1.2	-1.1	-0.2	-1.1	0.0	-0.6	0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	21.7	4.7	1.1	4.2	4.1	1.9	1.6	0.4	1.9	0.1	1.1	-0.6	1.3
Age at last live birth	1.6	2.3	5.2	2.3	1.1	1.2	1.8	1.3	1.4	2.1	1.7	1.3	1.6	1.3	1.5
Medication: Lisinopril	1.6	2.1	5.9	-1.4	-0.8	-1.6	-1.0	-0.8	-1.4	-1.6	-1.4	-1.8	-1.7	-2.4	-1.4
Taking other prescription medications	1.5	2.3	4.8	-1.3	-1.0	-1.2	-1.8	-2.2	-1.9	-1.7	-1.2	-1.5	-1.7	-1.3	-1.8
Diabetes (self-reported)	1.5	2.3	5.8	-2.4	0.4	-2.4	-1.8	-1.1	-1.6	-0.4	-1.3	-1.4	-1.6	-1.6	-1.5
Alcohol intake versus 10 years previously	1.5	2.2	5.6	-2.4	-1.2	-1.5	-2.3	-1.9	-1.4	-1.6	-1.0	-1.0	-1.1	-0.6	-1.5
Medication: Allopurinol	1.5	2.0	8.1	1.7	2.8	1.7	1.2	1.3	0.9	0.8	0.9	1.1	1.2	1.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.5	1.5	1.5	1.3	1.9	1.0	1.3	1.2	1.2	1.1	1.1	1.2	1.1
Medication: Gliclazide	1.5	1.7	2.9	-1.7	-0.5	-1.2	-1.1	-1.1	-1.5	-1.5	-1.2	-1.5	-1.5	-1.5	-1.6
Neuroticism	1.4	3.5	14.4	2.7	0.6	3.8	3.6	1.9	1.1	-0.4	1.8	-0.0	0.6	-0.4	1.0
Neuroticism score	1.4	2.9	12.6	2.7	0.1	3.6	3.1	1.6	1.2	0.1	1.6	0.0	0.6	-0.7	1.1
Father’s age at death	1.4	1.8	6.6	2.3	1.3	2.0	2.6	1.3	0.8	0.7	1.2	0.6	0.9	0.6	0.8
Happiness	1.4	1.6	7.6	1.9	2.8	1.0	2.0	0.8	0.6	1.5	1.0	0.3	0.6	0.2	0.6
Medication: Cholesterol lowering	1.4	2.1	7.7	-2.0	-0.8	-2.8	-1.9	-0.7	-1.4	0.5	-1.8	-0.9	-1.5	-1.0	-1.3
Exposure to tobacco smoke outside home	1.4	1.8	3.2	-1.7	-1.0	-1.3	-1.3	-1.1	-1.6	-0.4	-1.4	-1.4	-1.8	-1.6	-1.6
Diabetes diagnosed by doctor	1.4	2.3	6.5	-2.6	-0.3	-2.5	-2.1	-1.0	-1.6	-0.8	-1.4	-1.1	-1.6	-1.2	-1.5
Age started oral contraceptive pill	1.4	1.8	3.2	-0.2	-1.4	-0.8	-0.8	-1.8	-1.6	-1.4	-1.6	-1.6	-1.4	-1.5	-1.6
Basal cell carcinoma (self-reported)	1.4	1.6	7.1	0.9	2.7	1.1	1.4	1.3	1.1	1.5	1.0	0.9	1.1	0.9	1.1
Prostate Cancer	1.3	1.8	4.6	-0.7	0.6	-0.4	0.3	-0.7	-1.5	-0.9	-1.7	-2.1	-2.0	-2.1	-1.7
Qualifications: CSEs or equivalent	1.3	1.8	5.4	-1.3	-0.5	-1.1	0.0	-1.5	-1.0	-1.6	-1.3	-1.7	-1.7	-2.3	-1.2
Qualifications: None of the above	1.3	2.9	9.4	-1.2	-3.1	-0.8	-1.2	-1.3	-1.7	-1.7	-1.3	-1.8	-2.1	-2.1	-1.8
Time employed in main current job	1.3	1.5	3.2	-1.8	-1.2	-0.5	-1.4	-1.2	-1.5	-0.7	-1.1	-1.4	-1.2	-1.3	-1.4
Forced vital capacity (FVC), Best measure	1.3	4.8	22.8	4.8	0.8	3.7	4.1	1.2	0.8	-0.1	1.4	-0.9	0.4	-1.7	0.6
Number of children fathered	1.3	1.4	3.0	0.7	0.2	0.9	0.5	1.3	1.7	-0.2	1.5	1.7	1.5	1.5	1.7
Health satisfaction	1.3	1.7	10.6	-3.3	0.5	-0.6	-2.5	-0.8	-0.8	0.4	-1.0	-0.6	-1.2	-0.6	-0.9
Medication: Blood pressure	1.3	2.3	7.4	-1.6	-0.3	-1.6	-1.4	-0.9	-1.2	-0.6	-2.0	-1.8	-2.0	-2.7	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.3	1.0	1.0	1.3	-0.4	1.5	1.8	0.6	1.7	1.3	1.4	0.9	1.8
Supplements: Calcium	1.3	1.4	3.4	-0.3	-0.1	-1.2	-1.4	-1.8	-1.5	-0.4	-1.3	-1.4	-1.3	-1.0	-1.6
Age when periods started (menarche)	1.2	2.8	6.7	-0.1	-0.8	-1.5	0.7	-1.3	-2.6	-0.4	-1.8	-2.5	-1.9	-2.4	-2.4
Impedance of arm (right)	1.2	5.5	19.3	3.6	2.4	1.9	4.4	1.9	0.6	2.8	2.2	1.3	2.3	2.4	1.0
Medication: Lansoprazole	1.2	1.4	3.4	-1.5	-1.7	-0.4	-1.8	-0.9	-1.2	-1.4	-1.1	-0.8	-1.3	-0.8	-1.0
Illnesses of siblings: Diabetes	1.2	1.5	3.5	-1.0	-1.5	-1.4	-1.9	-1.4	-1.6	-0.6	-1.1	-0.9	-1.2	-0.5	-1.4
Fasting Glucose	1.1	1.3	2.9	1.1	0.7	0.5	1.2	0.9	1.2	1.7	1.6	1.3	1.3	0.9	1.5
Relative age of first facial hair	1.1	2.2	8.6	-1.0	-2.9	-2.7	-0.9	-1.0	-1.4	-0.2	-0.9	-1.3	-1.2	-1.3	-1.3
Ever had hysterectomy (womb removed)	1.1	1.2	4.2	-2.0	-1.2	-1.3	-1.4	-1.2	-1.2	0.3	-1.0	-0.7	-1.1	-0.4	-1.1
Medication: Metformin	1.1	1.5	4.3	-1.8	-0.4	-2.1	-1.6	-1.1	-1.2	-1.0	-0.9	-1.0	-1.2	-0.9	-1.2
Relative age voice broke	1.1	1.7	8.1	-1.8	-1.5	-2.8	-0.9	-1.0	-1.6	-0.2	-1.1	-0.7	-0.8	0.0	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	5.4	-1.6	-1.3	-1.2	-2.3	-0.9	-1.2	-0.4	-1.2	-0.4	-0.9	-0.1	-1.0
Number of full sisters	1.1	1.4	4.9	-2.1	-2.2	-1.5	-1.6	-0.6	-0.7	-0.0	-0.5	-0.6	-0.9	-1.2	-0.4
Long-standing illness, disability or infirmity	1.1	1.7	8.1	-1.5	-2.1	-1.5	-2.8	-1.0	-0.9	-1.2	-1.0	-0.4	-0.8	-0.4	-0.6
Commuting to job workplace: Public transport	1.1	1.3	2.8	-1.3	-1.7	-1.4	-1.4	-1.5	-1.2	-0.3	-0.8	-1.0	-0.9	-1.0	-0.9
Average weekly beer plus cider intake	1.1	1.6	4.4	1.1	0.0	1.0	1.8	1.1	0.9	1.1	1.6	1.5	1.5	2.1	1.0
Irritable Bowel Disease (IBD)	1.0	2.3	6.5	0.7	-0.0	2.5	1.2	2.0	2.0	1.6	1.8	1.2	1.3	0.2	2.2
Average weekly fortified wine intake	1.0	1.2	2.3	0.2	-1.4	0.1	0.3	1.0	1.1	0.7	1.5	1.4	1.5	1.5	1.3
Chronic bronchitis/emphysema (father)	1.0	1.1	4.8	-0.6	-2.2	-1.5	-2.1	-1.0	-0.9	-0.4	-0.6	-0.1	-0.5	0.2	-0.7
Forced vital capacity (FVC)	1.0	3.7	14.5	3.8	0.4	3.7	3.2	0.8	0.5	-1.0	0.8	-1.4	-0.2	-2.3	0.1
Mouth/teeth dental problems: Dentures	1.0	1.7	8.4	-2.0	-2.9	-0.2	-2.2	-0.3	-0.1	-1.2	-0.8	-0.7	-0.9	-1.2	-0.3
Heart disease (mother)	1.0	1.3	2.8	-0.8	0.1	1.6	0.7	1.2	1.7	0.6	1.3	1.4	1.0	0.8	1.7
Chest pain or discomfort	1.0	1.4	3.2	-0.9	-0.2	-1.7	-1.8	-1.8	-1.4	0.1	-1.5	-0.8	-1.3	-0.6	-1.2
Miserableness	1.0	1.8	4.6	1.5	-0.1	1.6	1.7	2.1	1.7	0.5	1.9	0.9	1.0	0.3	1.6
Fractured/broken bones in last 5 years	1.0	1.3	5.2	-0.7	-1.6	-2.3	-1.6	-1.1	-1.2	-0.7	-1.0	-0.6	-0.9	-0.3	-1.0
Had menopause	0.9	1.2	5.6	-0.7	-1.3	-1.4	-2.4	-1.4	-1.2	0.6	-0.9	-0.4	-0.5	0.0	-0.9
Allergy	0.9	2.0	5.4	-0.0	1.3	1.4	0.6	1.7	2.1	2.3	1.3	1.1	1.3	0.3	1.9
Loud music exposure frequency	0.9	1.0	3.7	0.9	0.2	0.4	0.1	1.1	1.1	-0.0	1.0	1.6	1.1	1.9	1.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.0	1.6	0.1	2.0	1.4	0.4	1.1	-0.6	1.6	1.0	1.4	1.5	0.9
Age at first live birth	0.9	1.6	5.5	2.3	1.7	1.0	2.3	1.2	0.7	0.5	1.1	0.8	1.2	1.1	0.8
Leg pain on walking	0.9	1.2	4.9	0.7	2.2	1.1	1.2	1.3	1.5	0.6	1.0	0.5	0.5	-0.1	1.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	4.4	-1.4	-0.6	-2.0	-2.1	-1.0	-0.8	-0.6	-0.7	-0.4	-0.6	-0.1	-0.8
Mineral and other dietary supplements	0.9	1.3	2.5	0.1	-1.0	-1.0	-0.1	-0.8	-1.3	-0.9	-1.6	-1.5	-1.5	-1.6	-1.4
Neuroticism (2016)	0.8	1.1	4.5	1.3	0.1	2.1	1.8	0.8	0.9	0.3	1.3	0.5	0.7	0.4	0.8
Height	0.8	15.0	25.7	-2.1	-0.6	-4.2	-4.6	-4.2	-4.4	-4.0	-4.0	-5.1	-4.1	-4.8	-4.3
Medication: Simvastatin	0.8	1.1	4.1	-2.0	-0.5	-1.8	-1.6	-1.2	-0.7	0.3	-0.8	-0.4	-1.0	-0.4	-0.8
Noisy workplace	0.8	1.0	2.8	0.7	0.9	1.7	1.0	1.0	1.2	1.4	1.0	0.6	0.6	-0.2	1.2
Impedance of arm (left)	0.8	3.9	14.4	3.1	1.9	1.5	3.8	1.6	0.3	2.2	1.9	1.0	1.9	2.1	0.6
Pulse wave reflection index	0.8	0.9	2.7	-0.3	-1.2	-0.7	-0.6	-1.0	-0.7	-1.6	-1.0	-1.0	-1.2	-1.2	-0.9
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.8	0.3	-0.2	-0.6	-0.7	-1.3	-0.8	-0.6	-0.6	-1.3	-1.3	-2.0	-0.8
Osteoporosis (self-reported)	0.8	1.0	3.4	-1.2	-1.3	-1.0	-1.9	-0.8	-0.8	-0.7	-0.8	-0.8	-0.7	-1.0	-0.7
Illnesses of father: High blood pressure	0.8	0.9	2.5	-1.6	-0.9	-0.3	-0.3	1.3	1.4	0.1	1.0	1.2	0.8	0.8	1.2
Alcohol drinker status: Never	0.8	0.9	3.4	-1.3	-1.9	0.0	-1.6	-1.1	-0.7	-0.6	-0.7	-0.8	-0.7	-0.8	-0.7
Risk taking	0.8	1.2	3.5	-0.2	0.7	-0.5	-1.4	1.4	1.1	0.9	0.8	1.5	1.3	1.9	1.1
Bipolar Disorder or Schizophrenia	0.7	1.8	4.3	0.9	0.2	-1.1	-0.0	-1.3	-2.1	0.3	-1.5	-1.9	-1.6	-1.5	-2.0
Coronary Artery Disease (CAD)	0.7	0.9	3.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.8	1.6	1.6	1.7
Ulcerative Colitis	0.7	1.0	2.1	0.5	-1.5	1.2	-0.9	1.1	1.2	0.3	0.8	1.2	1.0	0.9	1.4
Average weekly spirits intake	0.7	0.9	4.9	-2.2	-1.0	-0.7	-0.8	-0.4	-0.9	-0.4	-0.8	-0.7	-1.1	-0.8	-0.8
Sensitivity / hurt feelings	0.7	1.3	6.6	1.7	0.1	2.0	2.6	0.6	0.8	0.5	0.9	0.1	0.6	-0.1	0.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.8	1.7	-0.6	-0.4	-0.7	-1.1	-1.3	-1.2	0.8	-1.0	-0.9	-1.1	-0.9	-1.1
Hearing difficulty/problems with background noise	0.7	1.2	5.2	-2.3	-1.1	-1.2	-1.3	-1.2	-1.3	-0.3	-0.7	-0.6	-0.7	0.0	-1.1
Mood swings	0.7	1.3	5.1	1.7	0.0	2.3	2.0	1.3	0.9	-0.5	1.2	0.1	0.3	-0.6	0.8
Qualifications: nursing, teaching	0.7	1.1	2.0	1.1	1.1	0.4	0.8	1.1	0.9	1.4	0.8	1.3	1.4	1.4	1.1
Hearing aid user	0.7	0.8	4.5	-1.5	-2.1	-1.0	-1.5	-0.5	0.2	0.2	-0.2	0.3	-0.2	0.4	0.1
Ever depressed for a whole week	0.7	0.8	3.5	1.1	1.2	1.9	1.8	0.4	0.3	0.4	0.6	0.2	0.4	0.3	0.3
Bipolar Disorder (2018)	0.6	1.0	2.5	-0.2	0.7	-1.1	-0.8	-1.4	-1.6	-0.2	-1.1	-1.1	-1.1	-0.8	-1.4
Depressed Affect (Nagel 2018)	0.6	1.3	4.8	1.2	-1.4	2.2	1.4	1.2	0.2	-1.5	0.6	-0.7	-0.5	-1.5	0.1
Age at First Birth	0.6	0.8	3.8	1.7	1.3	0.5	1.9	-0.1	0.0	1.1	0.8	0.2	0.6	0.3	0.2
Schizophrenia (2014)	0.6	1.4	3.3	0.9	0.4	-0.4	1.0	-1.2	-1.8	0.3	-1.1	-1.7	-1.4	-1.4	-1.8
Fed-up feelings	0.6	1.2	5.2	0.2	-1.0	0.8	0.5	0.0	-0.3	-2.1	-0.3	-1.4	-1.1	-2.3	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	-1.1	-0.8	-0.6	-0.7	-1.0	-0.8	-0.9	-0.6	-0.9	-0.9	-1.3	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.0	-0.7	-1.4	-1.3	-1.4	-1.1	-0.7	-1.2	-0.6	-0.5	-0.6	-0.4	-0.6
Prospective memory result	0.6	0.8	3.6	1.9	0.8	1.8	0.4	-0.1	-0.0	0.5	0.1	-0.7	-0.4	-1.3	-0.1
Length of working week for main job	0.6	0.7	2.0	0.4	0.2	-0.6	-0.8	0.5	-0.9	-1.4	-0.9	-1.1	-0.9	-1.0	-1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.0	-1.2	-0.5	-0.8	-0.0	-1.0	-1.0	-0.7	-0.4	-1.1	-1.0	-1.7	-0.7
Family relationship satisfaction	0.6	0.8	3.8	1.4	1.9	-1.2	0.3	-0.6	-0.3	1.3	-0.1	0.1	0.2	0.7	-0.3
Medication: Aspirin	0.6	0.9	5.9	-0.4	0.1	-0.7	-0.5	0.3	0.8	2.4	0.8	1.0	0.6	0.9	0.9
Wears glasses or contact lenses	0.6	0.7	2.2	-0.4	-1.5	-0.8	-1.3	-1.2	-0.8	-0.6	-0.9	-0.6	-0.6	-0.6	-0.7
Mother’s age at death	0.6	0.8	7.6	0.9	2.8	0.2	0.2	0.5	0.2	0.8	0.4	0.2	0.4	0.2	0.3
Alcohol drinker status: Previous	0.6	0.7	1.9	-0.8	-0.5	-1.4	-0.9	-0.4	-0.7	-0.7	-0.9	-0.8	-1.1	-1.0	-0.8
Schizophrenia (2018)	0.5	1.1	2.2	1.4	-0.0	-0.5	1.2	-0.5	-1.4	0.6	-1.0	-1.5	-1.2	-1.4	-1.4
Mean Putamen Volume	0.5	0.5	2.8	-1.1	-0.1	-0.2	-0.1	-0.0	-0.7	-1.7	-0.1	-0.8	-0.6	-1.0	-0.5
Smoking Status	0.5	1.2	2.8	-1.3	0.5	-1.0	0.2	0.9	1.5	0.0	1.5	1.7	1.2	1.2	1.4
Vitamin and mineral supplements	0.5	0.7	2.1	1.0	0.0	1.1	1.5	1.3	0.7	0.0	0.6	0.7	0.8	0.4	0.8
Supplements: Zinc	0.5	0.6	2.2	1.5	0.9	1.1	0.3	0.0	0.8	0.6	1.0	0.4	0.7	0.2	0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.1	0.1	0.2	1.3	1.3	0.3	0.3	1.8	0.5	-0.2	0.0	-0.9	0.4
Mouth/teeth dental problems	0.5	0.8	3.8	1.4	2.0	0.5	1.6	0.3	0.1	0.8	0.0	0.2	0.5	0.7	-0.1
Heart attack	0.5	0.6	1.9	0.7	0.5	-0.1	0.5	0.8	0.6	0.5	0.8	1.2	0.8	1.4	0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	4.4	1.5	-0.4	1.0	2.1	-0.1	-0.7	-0.8	0.5	-0.2	0.1	0.3	-0.4
Illnesses of mother	0.5	0.7	5.0	2.2	0.2	0.6	0.9	0.4	0.2	0.4	0.7	0.4	0.9	0.8	0.4
Hair/balding pattern: Pattern 4	0.5	1.2	2.2	-1.0	-0.2	0.4	-1.5	-1.3	-1.3	-0.8	-1.3	-1.2	-1.4	-1.3	-1.2
Number of full brothers	0.5	0.6	2.5	-0.8	-0.9	-1.3	-1.6	-0.7	-0.4	0.3	-0.5	-0.4	-0.9	-0.5	-0.6
Worry too long after embarrassment	0.5	0.9	3.3	1.3	0.7	1.8	1.8	0.7	0.7	0.6	0.9	-0.2	0.3	-0.5	0.5
Shortness of breath walking on level ground	0.5	0.6	1.3	0.7	-1.1	0.4	-1.0	0.7	0.8	0.3	0.5	1.0	0.6	0.9	0.8
Eye problems/disorders: None of the above	0.5	0.5	1.6	-0.9	-0.6	-0.3	0.2	-0.9	-0.7	-1.3	-0.7	-0.7	-0.8	-0.8	-0.6
Medication: Ibuprofen	0.5	0.6	2.3	-0.6	-1.5	-1.5	-1.0	-1.1	-0.6	-0.7	-0.4	-0.3	-0.3	-0.1	-0.4
Supplements: Vitamin C	0.5	0.6	1.4	1.1	1.2	0.7	0.5	0.2	0.5	1.2	0.8	0.5	0.7	0.8	0.4
Medication: Aspirin	0.5	0.7	5.3	-0.3	0.2	-0.5	-0.4	0.4	0.7	2.3	0.8	0.9	0.5	0.7	0.8
Guilty feelings	0.5	0.7	3.7	-0.7	0.1	0.5	-0.4	-0.5	-0.4	-0.2	-0.7	-1.3	-1.1	-1.9	-0.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	5.7	-1.1	-2.4	-0.9	-0.9	0.5	0.7	-0.0	0.5	1.4	1.0	0.8	0.8
Breast Cancer	0.4	1.0	4.6	-1.4	-1.8	-1.3	-2.1	-0.0	0.2	0.1	0.0	0.8	0.2	0.1	0.4
HDL Cholesterol	0.4	0.6	3.3	1.8	0.8	1.4	0.6	0.3	0.5	0.3	0.5	0.4	0.6	0.6	0.3
Systolic blood pressure, automated reading	0.4	1.2	6.2	-2.5	-0.7	-0.7	-1.1	-0.4	-0.0	0.3	-0.6	-1.0	-1.2	-1.9	-0.3
Current tobacco smoking	0.4	0.6	2.4	-1.3	-0.1	-0.9	-1.6	-0.3	-0.3	-0.7	-0.5	-0.5	-0.8	-0.9	-0.3
Maternal smoking around birth	0.4	0.6	1.7	-0.4	0.1	0.4	1.2	1.1	0.9	-0.2	1.3	0.7	0.7	0.4	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	0.5	-0.2	1.1	-0.2	0.6	0.9	0.7	0.9	1.0	0.6	0.9	1.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.7	1.6	-0.6	0.2	0.6	-0.8	-1.3	-1.9	-0.3	-0.8	-0.6	-0.0	-1.2
Stomach or abdominal pain in last month	0.4	0.5	1.0	-0.0	0.8	1.0	0.6	0.7	0.6	0.7	0.7	0.9	0.7	1.0	0.7
Medication: Atenolol	0.4	0.5	2.7	-1.6	-0.6	0.0	-0.5	-0.1	-0.3	0.2	-0.2	-0.8	-0.9	-1.1	-0.5
Medication: Levothyroxine sodium	0.4	0.6	1.5	-0.2	1.2	-0.7	-0.4	-0.6	-0.9	0.7	-0.9	-0.9	-0.8	-0.9	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	-0.1	0.3	0.7	0.0	-0.9	-1.0	0.2	-0.6	-1.0	-1.0	-0.9	-1.0
Fluid intelligence score	0.4	0.9	3.6	-1.0	-1.9	-1.3	-1.0	0.2	0.4	-0.6	0.0	1.1	0.5	1.5	0.4
Depression (self-reported)	0.4	0.5	1.1	-0.2	-0.5	-0.7	-0.6	-0.5	-0.8	-0.8	-1.1	-0.8	-0.9	-0.6	-1.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.5	1.1	0.4	1.6	1.1	0.6	0.3	-0.2	0.8	0.3	0.6	0.4	0.5
Gout (self-reported)	0.4	0.6	2.9	1.0	1.7	0.8	1.1	0.6	0.2	0.1	0.7	0.4	0.6	0.9	0.2
Birth weight	0.4	0.9	3.5	-1.4	-1.0	-0.9	-1.2	-0.9	-0.2	-0.7	-0.6	-0.9	-0.9	-1.9	-0.2
Friendships satisfaction	0.4	0.5	2.2	1.3	1.1	0.4	1.5	-0.3	0.2	0.8	0.5	-0.0	0.3	-0.1	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.8	-0.5	0.1	0.8	-0.6	-0.2	-0.5	0.6	-0.5	-0.9	-0.9	-1.3	-0.5
Heart disease (siblings)	0.4	0.5	1.1	-1.0	-0.2	-0.3	-0.9	-0.8	-0.6	0.1	-0.7	-0.7	-1.0	-1.0	-0.7
Pack years of smoking	0.4	0.5	2.6	-1.0	-0.4	-1.6	-1.6	-0.5	-0.5	-0.1	-0.4	-0.1	-0.4	-0.3	-0.2
Depression (Nagel 2018)	0.3	0.5	3.3	0.6	-1.8	1.2	-0.1	-0.0	-0.0	-0.0	0.5	0.4	0.1	0.6	0.2
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.8	0.1	-0.9	-0.5	-0.3	0.7	0.9	0.3	0.9	1.6	1.4	2.2	0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	2.9	-0.7	-1.7	0.7	0.5	0.0	-0.3	-0.2	-0.1	-0.4	-0.5	-0.7	-0.2
Ulcerative Colitis (UC)	0.3	0.6	1.6	0.2	-0.4	1.2	-0.1	1.0	1.2	-0.1	0.8	0.9	0.9	0.3	1.3
Body Mass Index (BMI) (2010)	0.3	0.5	2.3	-0.2	-1.5	-0.9	-1.1	-0.2	0.5	-0.2	0.3	0.5	0.4	-0.0	0.8
Systolic Blood Pressure	0.3	1.4	7.0	-2.6	0.6	-0.7	-0.1	-0.3	-0.3	-0.0	-1.0	-1.5	-1.6	-2.0	-0.7
Hypothyroidism (self reported)	0.3	0.7	3.3	0.8	1.8	0.3	1.3	-0.4	-0.6	1.2	-0.3	-0.7	-0.5	-0.5	-0.7
Chronotype (morning person)	0.3	0.7	3.8	0.5	-1.9	-0.2	-1.1	-0.3	-0.1	-1.1	-0.8	-0.6	-0.7	-0.4	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	0.1	0.5	0.9	-0.3	0.0	0.5	1.0	1.0	0.6	0.7	0.6	0.7
Medication for hormone replacement therapy	0.3	0.3	1.8	0.2	-0.9	0.3	-0.8	0.1	0.2	1.3	0.4	0.5	0.3	0.6	0.2
Pack years adult smoking proportion	0.3	0.5	2.5	-0.5	-0.5	-1.6	-1.3	-0.6	-0.5	-0.4	-0.5	-0.3	-0.5	-0.6	-0.2
High blood pressure (mother)	0.3	0.4	2.1	-0.8	0.4	0.1	-0.3	0.4	0.2	-0.9	-0.2	-0.5	-0.7	-1.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.5	-1.6	-0.8	-0.3	-0.5	-0.3	-0.7	0.0	-0.3	-0.6	-0.9	-0.9	-0.6
Number of live births	0.3	0.5	2.5	0.6	0.5	0.4	1.2	0.7	0.6	1.6	0.6	0.1	0.1	-0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.8	0.6	0.9	-0.1	0.8	-0.2	-0.4	0.8	0.5	0.6	1.0	1.9	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.3	-0.5	0.5	1.5	0.9	0.5	0.3	1.3	0.5	0.2	0.3	0.1	0.4
Had major operations	0.3	0.4	1.4	-0.8	1.2	-0.1	0.0	1.0	0.5	1.1	0.3	0.3	-0.0	-0.1	0.4
Loneliness, isolation	0.3	0.4	1.8	0.8	0.3	1.4	0.3	0.6	0.7	0.3	0.6	-0.0	-0.0	-0.8	0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	2.2	0.2	0.3	-0.9	-1.5	-0.8	-0.3	0.9	-0.1	0.1	-0.1	0.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	2.9	0.1	-1.7	-0.3	-0.3	-0.3	-0.3	0.2	-0.0	-0.4	-0.5	-0.8	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.1	0.7	0.1	0.6	1.1	0.2	0.6	0.8	0.7	0.5	0.5	0.4	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.4	0.7	0.4	-0.3	0.4	0.7	0.4	0.5	0.5	1.0	0.7	1.2	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.0	0.0	0.7	0.0	0.2	-0.1	0.1	0.7	0.3	1.0	0.7	1.4	0.4
Major Depression (MDD)	0.2	0.3	1.1	0.8	0.8	1.1	0.9	0.1	-0.1	-0.0	0.0	-0.4	-0.1	-0.3	-0.2
Reaction Time	0.2	0.4	1.3	-0.1	-1.1	-0.7	-0.2	1.1	0.5	0.1	0.2	0.9	0.6	0.3	0.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.3	-1.1	0.7	-0.5	0.2	0.2	-0.2	-0.0	0.3	-0.3	-0.0	-0.4	-0.0
Waist Hip Ratio (WHR)	0.2	0.9	2.8	-0.0	1.4	0.8	1.0	-0.0	-1.0	0.7	0.1	-1.7	-0.8	-1.5	-0.9
Allergy or Eczema	0.2	0.5	1.7	1.0	-0.5	0.3	0.2	-0.7	-1.3	-1.3	-0.2	-0.4	-0.3	-0.0	-1.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	0.7	-1.2	0.5	0.3	-0.2	-0.2	-0.9	0.5	0.1	-0.1	0.3	-0.2
Diabetes (father)	0.2	0.2	1.4	-0.6	1.2	-0.0	0.0	-0.1	-0.2	-0.9	0.0	0.0	0.1	0.3	-0.1
Severe depression (siblings)	0.2	0.3	0.5	-0.1	0.3	-0.3	0.2	-0.6	-0.5	-0.6	-0.6	-0.7	-0.7	-0.6	-0.6
Serious illness, injury or assault to yourself	0.2	0.3	0.8	0.7	0.9	-0.1	-0.5	-0.3	-0.3	0.7	-0.2	-0.3	-0.4	-0.9	-0.0
Multivitamins +/- minerals	0.2	0.3	1.0	-0.6	1.0	-0.5	-0.7	-0.2	0.4	0.8	0.4	0.3	0.4	0.5	0.3
Hair/balding pattern: Pattern 3	0.2	0.2	1.6	0.4	0.2	-1.3	-0.3	-0.3	-0.0	0.6	-0.3	0.3	0.3	0.6	0.1
Standing height	0.2	2.3	7.6	1.0	0.4	-1.3	-1.4	-1.4	-1.6	-1.3	-1.4	-2.3	-1.4	-2.8	-1.5
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.6	-0.5	-0.3	-0.8	-0.7	0.1	0.1	-0.3	-0.1	-0.2	-0.5	0.1
Peak expiratory flow (PEF)	0.2	0.5	2.3	1.5	0.2	1.2	0.7	0.9	0.6	0.4	0.2	-0.2	0.0	-0.8	0.4
Blood clot in the leg (DVT)	0.2	0.2	1.5	0.1	0.3	-0.1	-0.0	-0.3	-0.1	0.6	0.2	0.8	0.5	1.2	0.3
Glaucoma (self-reported)	0.2	0.2	0.6	0.1	-0.7	0.7	0.1	0.7	-0.0	-0.8	0.1	-0.4	-0.1	-0.7	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	0.4	0.9	-0.4	0.4	-0.4	-0.7	0.9	-0.5	-0.7	-0.5	-0.6	-0.7
Medication: Amlodipine	0.2	0.3	0.9	-0.2	-1.0	0.6	0.5	0.9	0.7	0.9	0.5	0.1	0.1	-0.5	0.5
Mean time to correctly identify matches	0.2	0.4	1.3	0.3	-0.8	-0.2	-0.3	0.9	0.4	0.9	0.2	0.9	0.7	1.2	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.7	-0.4	0.2	0.1	0.1	0.1	0.1	-0.1	0.3	0.7	0.7	1.3	0.3
Ever had bowel cancer screening	0.2	0.2	1.1	-0.7	0.9	0.2	-0.4	-0.0	-0.0	1.0	-0.0	0.2	0.2	0.2	0.1
Commuting to job workplace: Walk	0.2	0.2	1.5	1.2	-0.8	0.5	0.1	0.4	-0.2	0.0	0.3	-0.4	0.1	-0.4	-0.0
Eye problems/disorders: Cataract	0.2	0.3	2.9	-0.3	0.3	-0.4	-0.3	-0.2	-0.2	1.7	-0.2	-0.1	-0.1	0.2	-0.3
Smoking status: Current	0.2	0.3	1.6	-1.1	0.1	-0.4	-1.3	0.0	0.0	-0.3	-0.0	-0.2	-0.4	-0.6	0.0
Ever taken oral contraceptive pill	0.2	0.2	1.0	-0.2	0.2	1.0	0.2	0.8	0.6	0.0	0.6	0.2	0.2	-0.3	0.7
Financial situation satisfaction	0.2	0.3	2.4	0.7	1.5	-0.3	0.0	-0.2	0.2	0.4	-0.3	-0.2	-0.3	-0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	2.2	-0.5	-1.5	-0.3	0.3	-0.1	0.3	-0.1	0.1	0.1	0.0	-0.1	0.2
Ovarian Cancer	0.1	0.1	0.3	0.6	0.4	0.4	0.3	0.2	-0.1	-0.0	0.3	0.1	0.2	0.1	0.0
LDL Cholesterol	0.1	0.2	0.6	0.4	-0.6	-0.1	-0.3	0.4	0.4	0.4	0.4	0.8	0.5	0.8	0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.7	0.6	-0.1	-0.2	0.6	0.5	0.3	0.8	0.1	0.3	0.1	0.4	0.1
Angina	0.1	0.2	0.6	-0.8	-0.2	0.6	-0.4	0.2	0.6	0.5	0.1	0.2	-0.1	-0.4	0.6
Alcohol usually taken with meals	0.1	0.2	0.6	-0.1	-0.7	0.3	-0.7	0.2	0.2	-0.4	0.2	0.3	0.4	0.3	0.3
Hair/balding pattern: Pattern 2	0.1	0.2	1.0	-0.4	-1.0	-0.0	0.3	0.1	-0.5	-0.6	0.1	-0.0	0.0	0.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.5	-0.1	-0.6	0.1	-0.5	-0.6	-0.3	-0.7	-0.4	-0.3	-0.2	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	1.1	-1.0	0.3	-0.4	0.2	-0.3	-0.1	0.2	0.3	0.0	0.4	0.1	0.2
Angina (self-reported)	0.1	0.2	0.6	-0.8	-0.1	0.6	-0.5	0.3	0.6	0.4	0.1	0.3	-0.1	-0.3	0.6
Migraine (self-reported)	0.1	0.2	0.6	-0.4	0.1	0.2	0.3	0.7	0.2	-0.1	0.5	0.6	0.4	0.8	0.3
Medication: Omeprazole	0.1	0.1	1.0	-0.1	-1.0	0.3	0.2	-0.1	0.3	-0.0	0.3	-0.0	-0.0	-0.4	0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.9	0.8	-0.2	-0.9	-0.2	0.2	-0.1	-0.4	-0.2	0.1	-0.0	0.3	-0.2
Comparative height size at age 10	0.1	0.4	1.9	0.3	1.3	-0.1	-1.4	0.4	0.5	-0.7	-0.0	-0.3	-0.0	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.0	1.0	-0.9	0.5	0.1	0.1	0.3	-0.9	0.3	-0.2	0.2	-0.5	0.3
Average weekly red wine intake	0.1	0.2	0.9	0.1	-0.6	0.2	-0.2	0.3	0.2	0.2	0.3	0.5	0.5	0.9	0.2
Osteoarthritis (self-reported)	0.1	0.1	0.7	-0.8	-0.3	0.1	-0.4	0.4	0.3	-0.4	-0.0	0.1	0.1	-0.1	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	0.4	-0.2	0.6	0.3	0.6	0.2	-0.6	0.2	-0.3	0.0	-0.5	0.0
Commuting to job workplace: Cycle	0.1	0.2	0.6	0.1	-0.0	-0.4	0.7	-0.1	-0.1	0.8	0.3	0.3	0.4	0.7	0.1
Bipolar Disorder (2011)	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1	0.5	-0.6
Hair Pigment	0.0	0.7	2.7	1.0	0.9	1.1	1.6	1.1	0.6	0.1	0.8	0.4	0.5	0.2	0.6
Tanning	0.0	0.2	1.2	0.8	0.0	0.2	1.1	0.3	0.0	-0.0	-0.1	0.2	0.2	1.0	-0.1

Hub : Genes

C16orf93

Models

Trait associations