Hub : Genes

STX4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0630 0.0300 1.9e-03 0.048 NA -0.002 NA 0.020 7.7e-05 NA 5.0e-01 NA 7.8e-03
2 GTEx Brain Cerebellum 0.1370 0.0580 2.4e-04 0.247 NA 0.161 NA 0.243 6.5e-08 NA 1.8e-05 NA 8.3e-08
3 GTEx Brain Nucleus accumbens basal ganglia 0.1910 0.0900 3.8e-03 0.108 NA 0.087 NA 0.062 8.0e-04 NA 2.6e-03 NA 9.7e-03
4 GTEx Colon Transverse 0.1020 0.0560 4.5e-03 0.095 NA 0.045 NA 0.062 2.9e-05 NA 3.3e-03 NA 6.6e-04
5 GTEx Esophagus Gastroesophageal Junction 0.0910 0.0510 6.1e-03 0.003 NA -0.008 NA -0.008 2.5e-01 NA 9.9e-01 NA 9.8e-01
6 GTEx Esophagus Mucosa 0.0840 0.0360 2.5e-04 0.000 NA 0.023 NA 0.022 2.9e-01 NA 1.0e-02 NA 1.3e-02
7 GTEx Esophagus Muscularis 0.0460 0.0270 9.1e-03 0.054 NA 0.005 NA 0.029 3.5e-04 NA 1.5e-01 NA 6.7e-03
8 GTEx Muscle Skeletal 0.0428 0.0217 4.3e-04 0.036 NA 0.023 NA 0.033 1.7e-04 NA 2.5e-03 NA 2.9e-04
9 GTEx Nerve Tibial 0.0652 0.0293 1.8e-04 0.041 NA 0.039 NA 0.022 6.4e-04 NA 9.4e-04 NA 9.8e-03
10 GTEx Ovary 0.1580 0.0870 7.7e-03 0.048 NA 0.069 NA 0.040 2.6e-02 NA 9.0e-03 NA 3.8e-02
11 GTEx Skin Sun Exposed Lower leg 0.0370 0.0190 1.5e-03 0.021 NA 0.038 NA 0.023 7.3e-03 NA 3.9e-04 NA 5.2e-03
12 GTEx Testis 0.1550 0.0780 2.3e-03 0.019 NA 0.011 NA 0.013 4.9e-02 NA 1.0e-01 NA 8.2e-02
13 GTEx Thyroid 0.0630 0.0280 6.0e-04 0.023 NA 0.032 NA 0.033 6.4e-03 NA 1.7e-03 NA 1.4e-03
14 ROSMAP Brain Pre-frontal Cortex 0.0642 0.0211 4.5e-12 0.114 0.101 0.102 0.099 0.107 1.8e-14 6.7e-13 5.4e-13 9.9e-13 1.4e-13
15 YFS Blood 0.0262 0.0091 4.4e-14 0.056 0.046 0.051 0.051 0.054 1.0e-17 5.8e-15 3.2e-16 3.4e-16 4.3e-17

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 1.1 1.8 7.6 1.3 1.0 -0.6 1.2 2.8 0.4 1.1 1.0 2.0 0.9 1.1 1.3 1.6 -1.0 1.1
Bipolar Disorder or Schizophrenia 0.6 1.5 4.3 1.6 0.8 -0.3 1.1 2.1 -0.1 1.0 1.1 1.6 0.3 1.1 1.5 2.0 -0.8 1.2
Depressed Affect (Nagel 2018) 7.4 15.6 23.5 -0.7 -4.3 4.0 -4.4 -1.7 -4.1 -4.6 -4.8 -3.4 -3.5 -2.8 -4.5 -4.7 4.3 -4.8
Depression (Nagel 2018) 1.1 1.6 3.8 -0.8 -1.4 0.8 -1.7 0.2 -0.3 -1.6 -1.6 -0.9 -1.1 -1.0 -1.6 -1.9 1.2 -1.3
Intelligence (Savage-Jansen 2018) 1.1 3.5 6.5 -0.1 2.1 -1.3 2.0 2.0 2.5 1.9 1.7 2.1 0.6 2.0 2.4 2.2 -1.9 1.8
Neuroticism (Nagel 2018) 12.2 28.6 40.3 -1.7 -6.2 5.5 -6.0 -2.9 -5.5 -6.2 -6.3 -4.8 -5.0 -3.8 -5.9 -5.4 6.2 -6.3
Schizophrenia (2018) 0.2 0.4 1.6 1.0 0.3 0.0 0.5 0.4 -0.5 0.4 0.6 0.5 -0.3 0.5 0.8 1.3 -0.2 0.7
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 -0.6 -1.1 0.4 -0.9 -0.7 -0.2 -0.8 -0.7 -1.0 -0.5 -0.5 -0.8 -0.6 1.0 -0.7
Worry (Nagel 2018) 9.6 20.3 31.1 -2.4 -5.3 4.0 -5.3 -2.6 -4.0 -5.4 -5.6 -3.8 -4.4 -3.1 -4.7 -4.1 5.4 -5.6
Alzheimer’s Disease (in mother) 4.3 5.1 7.7 -2.3 -2.6 1.7 -2.7 -0.9 -1.4 -2.7 -2.8 -2.1 -2.6 -2.2 -2.4 -0.5 2.6 -2.8
Alzheimer’s Disease (in father) 3.4 3.7 5.2 -2.2 -2.0 2.3 -2.2 -0.6 -1.1 -2.1 -2.1 -1.5 -2.3 -1.9 -2.2 -1.1 2.2 -2.1
Alzheimer’s Disease (including proxy) 10.0 14.5 21.2 -4.0 -3.9 3.6 -4.2 -1.5 -2.9 -4.3 -4.6 -3.6 -4.5 -4.2 -4.0 -1.7 4.0 -4.4
Crohns Disease (2017) 2.6 5.7 11.8 -2.7 -2.4 2.1 -2.1 0.5 -1.9 -2.2 -2.3 -2.6 -3.1 -3.4 -2.1 -2.9 2.1 -2.3
Irritable Bowel Disease (IBD) 1.9 4.6 8.6 -2.3 -2.5 2.1 -1.9 0.1 -1.8 -1.9 -1.9 -2.2 -2.4 -2.6 -2.0 -2.9 2.4 -1.9
Ulcerative Colitis (UC) 0.5 1.0 2.2 -1.3 -1.3 1.3 -0.7 0.1 -0.8 -0.7 -0.6 -0.9 -0.9 -0.7 -0.9 -1.4 1.5 -0.5
Major Depression (MDD) 1.2 1.4 2.4 -0.7 -1.6 1.4 -1.5 -0.2 -0.9 -1.2 -1.5 -1.0 -1.3 -0.8 -1.4 -1.0 1.4 -1.1
Reaction Time 0.6 1.1 3.4 -0.2 1.1 -1.2 1.3 -1.8 0.7 1.4 1.3 0.7 -0.1 0.3 0.8 0.9 -1.0 1.4
Verbal and Numeric Reasoning (VNR) 1.9 4.5 8.8 -0.5 2.3 -2.0 2.5 1.5 3.0 2.2 1.9 2.7 1.1 2.3 2.8 1.6 -2.2 2.0
Breast Cancer 1.8 4.3 6.9 -0.2 2.2 -2.3 2.2 1.2 2.6 2.5 2.6 2.2 1.6 1.8 2.3 1.1 -2.1 2.6
Ovarian Cancer 0.2 0.3 1.4 -0.7 -0.3 0.9 -0.1 -1.2 -0.6 -0.1 -0.2 -0.2 -0.3 0.3 -0.4 0.8 0.6 0.0
Prostate Cancer 0.4 0.6 1.5 1.2 -0.7 0.8 -0.7 -1.0 -1.1 -0.7 -0.5 -0.6 -0.3 0.4 -0.8 -0.6 0.8 -0.5
Age at First Birth 0.6 0.9 1.8 0.1 -1.3 1.2 -1.0 -0.6 -1.3 -0.9 -0.8 -0.7 -0.5 -0.2 -1.3 0.0 1.4 -0.8
Bipolar Disorder (2011) 0.5 0.4 3.2 0.9 -0.3 0.0 -0.0 1.4 0.4 -0.0 -0.0 0.4 -0.1 0.1 -0.2 1.8 0.3 -0.1
Body Mass Index (BMI) (2010) 2.0 2.7 5.2 -0.3 1.8 -1.6 2.0 0.8 1.3 2.1 2.2 1.3 1.4 0.5 2.3 0.8 -1.9 2.2
Coronary Artery Disease (CAD) 0.2 0.3 2.5 -1.6 0.3 0.1 0.0 0.7 0.5 -0.1 -0.4 0.0 -0.6 -0.1 0.2 -0.0 -0.1 -0.1
Crohns Disease (2012) 1.0 1.6 6.6 -2.6 -1.0 0.7 -0.6 0.6 -0.1 -0.8 -1.0 -1.2 -2.0 -2.3 -0.5 -0.9 0.7 -1.0
Mean Putamen Volume 0.4 0.5 1.3 0.2 -0.1 1.1 -0.4 0.6 -1.1 -0.7 -0.9 -0.6 -0.8 -0.9 -0.3 0.0 0.1 -0.9
Fasting Glucose 0.2 0.2 1.8 -1.3 0.2 0.1 0.0 0.1 0.6 -0.3 0.2 0.5 0.4 0.5 0.3 -0.2 0.1 0.2
HbA1C 1.7 1.8 4.3 2.0 0.8 -1.6 0.8 1.2 1.6 0.9 0.7 2.1 2.0 1.7 0.9 1.2 -0.9 0.6
HDL Cholesterol 1.4 2.3 4.4 -0.5 -1.9 2.1 -1.8 -0.3 -1.4 -1.9 -2.0 -1.1 -1.3 -0.7 -1.3 -0.4 1.9 -2.0
LDL Cholesterol 0.7 1.0 2.2 -0.5 0.8 -1.5 1.1 -0.1 1.3 1.2 1.3 1.2 0.8 1.3 0.6 -0.3 -0.7 1.3
Lupus 1.1 1.7 6.0 1.9 0.4 -0.9 0.4 2.1 -1.6 0.1 0.3 1.2 2.4 1.9 0.6 1.2 -0.6 0.2
Neuroticism (2016) 4.9 7.0 11.3 -1.0 -3.4 2.8 -3.1 -1.5 -2.7 -2.9 -3.3 -1.9 -2.3 -2.1 -2.7 -2.6 3.4 -2.7
Primary Biliary Cirrhosis 2.4 3.4 9.1 2.4 1.6 -1.7 1.8 1.4 1.0 1.5 1.4 2.3 3.0 2.3 2.0 0.8 -1.7 1.4
Rheumatoid Arthritis 0.8 1.1 8.7 3.0 -0.4 1.0 -0.5 -0.3 -1.1 -0.7 -0.6 0.5 1.3 0.5 -0.8 -0.7 0.5 -0.7
Schizophrenia (2014) 0.2 0.5 2.0 0.9 0.1 0.6 0.4 0.9 -0.8 0.4 0.5 0.5 -0.1 0.7 0.9 1.4 -0.0 0.6
Triglycerides 7.2 11.7 16.0 3.0 3.6 -3.6 3.9 1.3 3.2 3.9 3.9 3.9 4.0 3.4 3.0 1.3 -3.7 4.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.7 0.5 0.3 -0.2 -0.0 0.2 -0.3 -0.1 -0.1 -0.3 0.1 -0.8 -0.5 0.6 -0.4 -0.1
Ulcerative Colitis 0.6 0.9 3.9 -2.0 -1.0 0.7 -0.3 -1.5 -0.0 -0.3 -0.4 -0.5 -0.7 -0.8 -0.7 -1.3 1.1 -0.4
Blood Eosinophil Count 0.7 5.0 29.2 -5.4 -0.1 0.6 -0.1 2.7 1.7 -0.4 -0.9 -1.7 -3.9 -2.2 -0.3 3.2 0.5 -0.7
Blood Platelet Count 0.4 4.2 31.2 -5.6 -0.1 -0.7 0.4 2.3 1.9 0.5 0.3 -0.2 -4.1 -1.3 1.6 -0.2 -0.2 0.5
Blood Red Count 11.2 107.8 141.6 -6.0 -11.4 11.5 -11.3 -5.7 -10.4 -11.1 -10.8 -10.3 -11.0 -8.9 -11.7 -10.4 11.9 -10.8
Blood White Count 1.7 12.8 50.6 -5.6 -3.0 2.5 -2.6 -1.6 -1.9 -2.5 -2.7 -4.6 -7.1 -4.8 -2.5 -0.5 3.2 -2.5
Heel T-Score 2.0 16.1 29.8 -5.5 -4.2 3.8 -4.5 -0.7 -2.2 -4.2 -4.1 -4.5 -5.3 -5.2 -3.3 -1.0 4.1 -4.0
BMI 4.9 28.5 41.2 4.1 6.3 -4.9 6.2 1.1 4.2 6.1 6.0 5.9 6.2 5.1 6.2 0.8 -6.4 5.9
Height 0.2 4.5 21.2 4.6 1.9 -0.5 1.9 -0.5 -1.6 1.9 2.3 0.3 2.8 2.2 1.2 2.0 -2.0 2.1
Waist Hip Ratio (WHR) 0.6 2.6 11.8 0.7 -1.2 2.5 -1.0 -0.9 -3.4 -1.2 -1.3 -2.2 -0.9 -0.9 -1.8 0.0 1.6 -1.4
Systolic Blood Pressure 0.1 0.4 1.9 1.1 -0.2 1.0 0.1 -0.7 -0.8 -0.0 -0.2 0.2 -0.4 0.4 0.3 -1.4 0.0 -0.2
Smoking Status 1.5 3.6 7.6 -1.0 2.7 -1.3 2.3 2.0 2.1 2.3 2.0 1.0 -0.0 0.8 2.4 0.4 -2.8 2.2
Allergy or Eczema 0.4 1.1 6.4 -0.1 0.6 -0.6 0.6 1.6 1.0 0.4 0.4 1.4 0.6 0.9 1.1 2.5 -0.5 0.4
Cardiovascular Disease 6.3 20.9 29.4 3.4 5.4 -4.2 5.4 2.3 4.0 5.3 5.1 4.9 4.5 4.5 5.3 2.0 -5.4 5.1
Hypothyroidism (self reported) 1.2 2.7 6.1 0.6 -1.5 2.2 -1.5 -1.5 -2.5 -1.7 -1.7 -2.1 -1.1 -1.1 -1.9 -1.2 1.7 -1.7
Respiratory disease 3.7 8.2 12.7 3.2 2.9 -3.0 2.9 0.2 2.9 2.9 2.9 2.9 3.6 3.4 2.5 2.3 -2.9 2.8
Type 2 Diabetes (T2D) (2018) 0.8 1.5 4.7 2.2 1.4 -0.6 1.5 -0.6 0.1 1.5 1.6 0.9 1.1 0.9 0.6 -0.3 -1.3 1.6
Lung FEV1/FVC ratio 1.7 8.8 21.1 -4.6 -3.1 3.3 -2.8 0.9 -1.9 -2.9 -3.2 -2.7 -4.5 -1.9 -2.0 -1.7 3.3 -3.1
Lung FVC 9.0 45.7 61.8 -2.2 -7.9 7.2 -7.8 -4.1 -7.4 -7.8 -7.5 -6.2 -5.7 -5.6 -7.7 -6.0 7.8 -7.6
Neuroticism 10.0 24.2 33.8 -1.8 -5.8 5.1 -5.7 -2.3 -5.5 -5.8 -5.7 -4.4 -4.5 -3.1 -5.2 -5.0 5.8 -5.8
Chronotype (morning person) 0.7 1.6 6.2 0.4 -1.2 1.6 -1.2 -2.5 -1.4 -1.1 -1.0 -0.7 -0.5 -0.1 -1.4 -1.8 1.3 -1.0
Hair Pigment 0.1 1.7 4.7 -0.6 -1.4 0.6 -1.3 -0.6 -0.9 -1.3 -1.3 -1.8 -1.5 -2.2 -1.6 -0.5 1.4 -1.3
Tanning 0.0 0.2 1.1 0.1 0.2 -0.3 0.0 0.3 0.1 -0.0 -0.2 0.9 -0.2 0.6 0.7 1.1 -0.2 -0.2
Hand grip strength (left) 4.2 11.1 21.2 3.8 3.4 -2.3 3.2 1.1 2.8 3.5 3.6 3.9 3.8 4.6 3.5 1.7 -3.4 3.6
Number of treatments/medications taken 6.3 11.4 17.3 2.7 3.6 -3.1 4.0 1.9 2.5 3.8 3.7 3.6 4.2 3.3 3.6 3.0 -3.3 3.7
Average weekly spirits intake 0.6 0.7 4.1 0.7 0.7 -0.9 0.6 2.0 1.3 0.5 0.5 1.0 0.7 0.1 0.5 0.4 -0.8 0.4
Sensitivity / hurt feelings 3.6 6.1 8.9 -1.2 -2.8 2.8 -2.7 -2.7 -3.0 -2.6 -2.5 -2.7 -2.0 -1.8 -2.3 -2.2 2.7 -2.6
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.8 0.0 -0.7 0.8 -0.9 1.3 -0.0 -1.1 -1.1 -0.4 -0.8 0.1 -1.0 -1.1 0.5 -1.1
Hearing difficulty/problems: Yes 5.2 7.9 17.0 0.8 2.9 -3.4 2.7 3.3 4.1 2.7 2.5 3.2 2.7 2.1 2.6 2.4 -3.0 2.6
Relative age of first facial hair 2.0 4.1 6.7 2.1 2.6 -1.5 2.2 0.6 1.0 2.2 2.3 2.2 2.0 2.0 1.9 1.6 -2.5 2.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.0 0.9 0.9 -0.6 0.7 0.5 0.7 0.6 0.5 0.4 1.0 0.0 0.4 0.4 -0.9 0.5
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.4 -1.2 -0.5 0.8 -0.2 -1.1 -1.1 -0.5 -0.6 -0.7 0.0 -0.4 -0.5 -0.5 0.6 -0.6
Ever had hysterectomy (womb removed) 1.4 1.6 2.4 0.6 1.2 -1.4 1.5 0.2 1.5 1.5 1.5 1.4 1.3 1.3 1.2 0.2 -1.4 1.5
Systolic blood pressure, automated reading 0.2 0.5 3.0 0.5 0.1 0.2 0.4 -1.1 -0.4 0.4 0.2 0.8 0.4 0.8 0.6 -1.7 -0.2 0.2
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.8 0.2 0.5 -0.5 0.8 0.1 0.6 0.9 0.8 -0.0 -0.6 -0.1 0.5 0.2 -0.6 0.9
Angina 0.7 0.9 3.1 -0.8 -1.0 1.6 -0.6 0.0 -0.8 -0.6 -0.6 -1.0 -0.9 -1.2 -0.8 -1.8 0.8 -0.6
Medication for hormone replacement therapy 0.1 0.2 0.5 -0.7 0.3 0.0 0.5 0.7 0.2 0.3 0.1 -0.3 -0.1 -0.5 0.3 0.5 -0.3 0.2
Vitamin and mineral supplements 0.3 0.4 1.3 -0.9 -0.8 0.9 -0.6 -0.1 -0.6 -0.4 -0.4 -0.2 -0.7 0.4 -0.5 0.0 1.1 -0.5
Supplements: Zinc 0.8 0.9 2.7 -1.0 -0.9 1.6 -0.8 -0.9 -1.6 -0.6 -0.6 -0.8 -0.9 -1.0 -0.6 -0.8 1.0 -0.5
Medication: Co-codamol 1.7 2.0 3.2 1.1 1.7 -1.7 1.6 0.7 0.9 1.6 1.6 1.5 1.8 0.9 1.4 -0.0 -1.7 1.6
Medication: Metformin 1.3 1.8 3.2 1.8 1.6 -0.6 1.4 0.7 0.8 1.5 1.6 1.4 1.3 1.8 0.9 0.9 -1.4 1.6
Diabetes (father) 0.2 0.3 0.9 0.5 -0.9 0.5 -0.5 -0.1 -0.6 -0.5 -0.5 -0.3 -0.4 -0.1 -0.7 0.1 0.9 -0.5
Diabetes (mother) 0.3 0.4 0.9 0.1 0.8 -0.8 0.8 0.2 0.2 0.8 0.9 0.7 0.8 0.2 0.3 -0.5 -0.9 0.9
Severe depression (siblings) 0.2 0.3 2.4 1.0 0.0 0.3 0.0 -1.5 -0.6 0.0 -0.0 -0.1 0.3 0.3 -0.1 0.1 0.1 -0.1
Pack years adult smoking proportion 1.9 2.9 7.0 0.7 1.7 -2.6 1.8 1.6 2.1 1.7 1.6 1.4 1.7 1.4 1.8 1.2 -2.0 1.6
Impedance of leg (right) 0.7 3.6 10.1 -2.6 -1.7 1.2 -1.2 0.3 -1.3 -1.0 -1.0 -2.2 -2.9 -3.2 -1.9 2.5 1.8 -0.9
Leg fat-free mass (left) 2.0 10.7 19.5 4.2 3.8 -2.6 3.5 0.8 1.9 3.3 3.4 3.0 4.4 3.9 3.7 -0.2 -4.0 3.2
Trunk fat percentage 6.7 26.9 40.8 4.2 6.2 -4.7 6.4 1.5 3.7 6.3 6.3 5.0 5.3 4.5 5.6 2.7 -6.1 6.3
Hand grip strength (right) 2.9 7.8 15.6 3.9 2.8 -1.9 2.6 1.0 2.4 2.7 2.8 3.1 3.4 3.8 2.9 1.4 -2.9 2.7
Townsend deprivation index at recruitment 4.2 5.8 9.9 1.5 2.8 -2.1 3.0 2.0 2.1 2.8 2.8 2.3 2.1 1.9 3.1 1.1 -2.8 2.9
Current tobacco smoking 0.4 0.6 1.8 0.4 1.2 -0.6 1.1 -0.0 1.1 0.9 0.7 0.2 0.3 0.4 0.7 -0.3 -1.3 0.7
Average weekly fortified wine intake 0.4 0.4 1.3 -0.4 0.8 -1.1 0.5 0.2 0.7 0.5 0.4 0.5 0.1 -0.5 0.8 1.0 -0.9 0.3
Maternal smoking around birth 0.2 0.3 1.6 -0.7 0.1 -0.4 -0.1 1.3 0.6 -0.4 -0.7 -0.6 -0.7 -0.5 -0.1 -0.4 -0.3 -0.7
Fed-up feelings 3.7 6.7 10.2 0.5 -2.8 3.2 -2.9 -0.8 -3.2 -3.0 -2.9 -2.4 -2.0 -1.4 -2.9 -3.1 2.7 -3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 4.1 -1.4 -0.9 1.0 -0.8 -0.8 -0.5 -0.8 -0.9 -0.9 -1.1 -0.6 -1.0 -2.0 0.9 -0.8
Relative age voice broke 5.4 8.2 11.6 2.1 3.4 -2.8 3.0 2.9 2.6 3.0 2.9 2.9 2.2 2.4 2.7 3.3 -3.4 2.9
Taking other prescription medications 1.3 2.0 5.2 1.0 1.2 -1.3 1.6 1.8 1.6 1.4 1.4 1.2 2.3 1.2 1.0 1.2 -1.1 1.4
Age when periods started (menarche) 0.4 0.9 6.9 2.6 -0.3 0.6 -0.2 -0.1 -1.0 -0.3 -0.2 0.5 0.4 1.6 -0.2 1.4 0.3 -0.2
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.6 0.4 0.4 -0.5 0.6 -0.3 0.5 0.5 0.5 0.2 0.8 0.6 0.5 0.0 -0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 4.1 -1.8 -1.3 1.0 -1.5 -0.4 -0.4 -1.3 -1.1 -1.5 -1.9 -2.0 -1.0 -0.6 1.0 -1.1
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 5.4 2.3 1.3 -1.3 0.9 0.6 1.0 1.0 1.2 2.0 1.9 2.0 1.5 1.2 -1.3 1.1
Qualifications: CSEs or equivalent 0.2 0.2 0.8 0.9 0.2 0.4 0.3 0.5 -0.8 0.3 0.5 0.1 0.4 0.1 0.4 -0.5 -0.4 0.5
Serious illness, injury or assault to yourself 0.2 0.2 0.8 0.2 0.1 0.8 0.2 0.4 -0.6 0.0 -0.1 0.6 0.3 0.9 0.1 -0.6 -0.1 -0.1
High blood pressure 3.5 9.8 14.9 3.1 3.6 -2.6 3.8 0.8 2.0 3.7 3.5 3.3 3.9 3.0 3.4 0.9 -3.7 3.4
Hayfever, allergic rhinitis or eczema 0.2 0.4 3.5 0.4 0.1 0.1 0.1 1.2 0.1 -0.0 -0.0 0.7 0.1 0.1 0.6 1.9 0.0 -0.0
Multivitamins +/- minerals 0.1 0.1 0.5 0.1 0.3 -0.2 0.2 -0.1 0.1 0.1 0.1 0.0 -0.3 -0.4 0.5 -0.0 -0.7 0.1
Stomach or abdominal pain in last month 0.1 0.2 1.5 -1.2 -0.2 0.4 0.2 -0.1 0.3 0.1 -0.2 -0.2 -0.8 -0.2 0.1 -0.1 0.2 -0.0
Supplements: Glucosamine 0.4 0.5 3.5 -1.9 -0.1 -0.1 -0.2 -0.8 0.3 -0.1 -0.0 -0.4 -0.9 -1.4 0.2 0.4 -0.1 0.0
Diverticular disease/diverticulitis (self-reported) 3.5 4.1 7.0 -1.3 -2.1 2.5 -1.9 -0.5 -2.7 -2.0 -2.0 -1.9 -1.6 -2.4 -2.1 -2.3 2.0 -2.1
Medication: Atenolol 0.3 0.4 1.8 0.1 -0.3 0.7 -0.7 -0.3 -0.8 -0.7 -0.8 -0.7 -0.4 -0.3 -0.5 -1.3 0.4 -0.8
Medication: Levothyroxine sodium 0.3 0.5 1.8 1.2 -0.3 1.3 -0.4 -0.0 -1.4 -0.5 -0.5 -0.7 -0.0 0.3 -0.8 -0.2 0.6 -0.5
Sitting height 0.6 4.3 9.2 -3.0 -1.7 1.2 -2.1 0.2 -1.1 -2.3 -2.4 -2.2 -2.9 -2.0 -1.8 -2.2 1.5 -2.3
Chronic bronchitis/emphysema (father) 6.4 7.5 10.9 -0.1 3.1 -2.8 3.3 2.2 2.9 3.0 2.8 2.9 2.3 2.7 3.1 2.3 -3.1 2.9
High blood pressure (mother) 0.2 0.3 0.8 -0.8 0.6 -0.3 0.5 -0.9 -0.4 0.5 0.5 0.0 -0.2 -0.2 0.5 -0.7 -0.7 0.4
Body mass index (BMI) 5.9 25.0 34.6 4.1 5.8 -4.6 5.8 1.3 4.2 5.7 5.7 5.3 5.8 5.1 5.5 0.5 -5.9 5.6
Impedance of leg (left) 0.7 3.4 8.1 -2.1 -1.7 1.5 -1.3 -0.3 -1.7 -1.2 -1.2 -2.1 -2.8 -2.8 -2.0 2.1 1.9 -1.1
Leg predicted mass (left) 2.0 10.8 19.0 4.1 3.8 -2.6 3.5 0.9 1.9 3.3 3.4 3.1 4.4 4.0 3.7 -0.2 -4.0 3.2
Trunk fat mass 6.2 26.6 39.7 4.5 6.3 -4.6 6.3 1.3 3.5 6.2 6.1 4.8 5.6 4.7 5.6 2.2 -6.2 6.1
Waist circumference 8.4 30.7 45.4 4.7 6.6 -4.8 6.7 1.9 3.6 6.5 6.3 5.8 6.5 5.6 6.0 1.9 -6.5 6.3
Number of incorrect matches in round 6.5 10.9 15.3 -1.9 -3.8 3.2 -3.7 -3.7 -3.3 -3.7 -3.7 -3.3 -3.2 -2.6 -3.2 -0.7 3.9 -3.7
Past tobacco smoking 1.4 2.6 5.1 2.3 -2.1 0.6 -1.9 -1.9 -1.7 -2.0 -1.8 -0.6 0.5 -0.1 -1.9 -0.5 2.1 -1.9
Alcohol usually taken with meals 0.2 0.3 1.1 -0.2 0.3 -1.0 0.1 0.3 0.7 0.2 0.3 0.1 0.4 -0.8 0.6 0.9 -0.4 0.3
Nervous feelings 7.0 13.1 20.7 -2.9 -4.4 3.1 -4.0 -1.8 -2.6 -4.3 -4.5 -2.8 -4.0 -3.0 -3.8 -2.7 4.4 -4.5
Frequency of tenseness / restlessness in last 2 weeks 5.7 8.9 16.3 -2.7 -3.0 3.0 -3.0 -1.7 -2.3 -3.2 -3.3 -3.2 -4.0 -2.3 -3.0 -3.2 2.9 -3.3
Hearing difficulty/problems with background noise 1.4 2.3 3.8 0.8 1.8 -2.0 1.6 1.4 1.9 1.3 1.2 1.6 1.6 1.0 1.5 1.8 -1.8 1.2
Hair/balding pattern: Pattern 2 0.2 0.2 1.6 0.5 0.1 -0.3 0.1 1.3 0.1 -0.1 -0.4 0.4 -0.3 0.6 0.4 0.3 -0.1 -0.4
Had menopause 2.3 2.9 5.0 0.6 1.8 -1.4 2.2 0.6 1.3 2.1 2.0 2.1 2.2 1.0 1.5 1.7 -1.7 2.0
Had other major operations 0.7 0.9 1.9 0.6 1.3 0.2 1.3 0.9 0.1 1.1 1.0 0.6 1.3 0.8 0.8 0.0 -1.4 0.9
Forced vital capacity (FVC) 7.5 29.1 47.6 -0.7 -6.0 6.3 -6.2 -3.1 -6.9 -6.1 -5.8 -5.7 -4.3 -3.6 -6.1 -4.6 6.0 -6.0
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.3 5.5 -1.7 -2.0 2.0 -2.1 -0.2 -1.3 -2.1 -1.9 -2.2 -2.3 -2.1 -1.6 -0.7 1.7 -1.9
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 2.9 0.2 -1.6 1.0 -1.3 -1.3 -0.7 -1.6 -1.7 -0.9 -0.6 -1.0 -1.4 -1.6 1.3 -1.7
Qualifications: None of the above 0.2 0.5 2.8 0.9 -0.2 -0.3 0.1 1.7 0.6 0.0 -0.0 0.5 0.8 0.6 -0.5 -1.2 0.3 -0.1
Financial difficulties in last 2 years 3.0 4.0 6.4 1.9 2.4 -1.5 2.5 2.5 1.0 2.2 2.2 1.9 1.8 2.1 2.0 0.0 -2.3 2.1
Mouth/teeth dental problems 0.4 0.6 1.3 0.3 -0.8 0.6 -0.9 -1.0 -1.1 -0.8 -0.9 -0.2 -0.6 -0.5 -0.8 0.4 0.8 -0.9
Heart attack 0.6 0.7 1.4 -0.6 0.8 -0.7 1.0 1.0 1.2 1.0 1.1 0.4 -0.1 -0.1 0.9 0.9 -0.9 1.1
Allergy 2.2 5.1 10.9 -1.4 -2.0 2.1 -1.9 -3.0 -2.5 -1.9 -1.8 -2.9 -2.0 -2.1 -2.2 -3.3 1.9 -1.8
Pain all over the body in last month 4.9 5.2 6.7 2.4 2.5 -2.3 2.4 1.4 2.5 2.2 2.2 2.3 2.1 2.5 2.6 1.8 -2.6 2.2
Diabetes (self-reported) 1.6 2.5 4.5 1.9 1.7 -1.1 2.0 0.0 1.1 2.1 2.1 1.4 1.4 1.8 1.1 0.7 -1.5 2.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.6 -0.4 -0.5 -0.1 -0.4 1.0 0.5 -0.4 -0.2 0.2 -0.1 -0.3 -0.1 1.3 0.5 -0.3
Medication: Ramipril 1.5 1.9 3.2 0.9 1.6 -0.9 1.7 1.7 1.2 1.8 1.6 1.4 1.4 1.1 0.8 0.5 -1.5 1.7
Medication: Simvastatin 4.3 6.2 8.7 0.7 2.8 -2.5 2.9 2.4 2.8 2.9 2.8 2.7 2.3 1.6 2.6 1.6 -3.0 2.8
Fluid intelligence score 3.3 6.9 11.9 -0.1 2.8 -2.9 3.1 2.7 3.5 3.0 2.6 2.8 1.0 2.0 3.3 1.8 -3.0 2.8
Illnesses of siblings 7.0 9.8 15.7 -1.6 -3.4 3.2 -3.7 -1.8 -3.3 -3.4 -3.2 -4.0 -2.9 -3.4 -3.7 -1.0 3.5 -3.3
Neuroticism score 10.5 21.9 29.5 -2.0 -5.3 4.8 -5.2 -2.7 -5.4 -5.4 -5.4 -4.3 -4.1 -3.3 -5.0 -4.9 5.2 -5.4
Weight 5.3 26.0 37.7 5.0 6.1 -4.3 6.0 1.3 3.4 5.8 5.8 5.0 6.1 5.3 5.5 1.1 -6.1 5.7
Impedance of arm (right) 0.6 2.9 6.3 -0.7 -1.5 1.9 -1.2 -1.0 -2.5 -1.1 -0.9 -2.3 -2.1 -1.9 -1.8 2.5 1.9 -0.9
Arm fat percentage (right) 6.6 26.2 37.7 4.3 6.1 -4.6 6.1 0.9 3.8 6.1 6.1 5.1 5.7 4.8 5.5 1.8 -6.0 6.1
Trunk fat-free mass 0.7 3.8 8.9 2.6 2.3 -1.3 1.9 0.4 0.7 1.8 1.8 1.7 3.0 2.5 2.1 -1.1 -2.5 1.7
Hip circumference 9.7 41.6 58.7 5.0 7.7 -5.8 7.6 1.9 5.1 7.5 7.4 6.9 7.0 6.6 7.2 2.4 -7.6 7.4
Time employed in main current job 0.2 0.3 0.9 0.9 0.4 0.0 0.4 0.1 -0.4 0.5 0.7 -0.1 0.3 -0.7 0.4 0.4 -0.7 0.6
Alcohol intake versus 10 years previously 2.4 3.6 5.0 1.1 2.2 -2.2 2.2 1.4 1.2 1.9 1.8 2.1 2.2 1.8 2.1 2.1 -2.1 1.8
Father’s age at death 2.0 2.7 3.9 -1.4 -1.8 1.7 -1.8 -1.1 -1.8 -1.8 -1.7 -1.4 -1.8 -1.6 -1.8 -0.6 2.0 -1.7
Worrier / anxious feelings 10.7 20.3 27.6 -2.5 -5.2 3.8 -4.9 -3.5 -4.1 -5.2 -5.2 -4.2 -4.2 -3.7 -5.0 -4.8 5.0 -5.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 1.4 0.1 0.3 0.3 0.4 0.7 0.3 -0.0 -0.4 0.1 -0.5 -0.0 0.2 -1.2 -0.4 -0.3
Falls in the last year 3.4 4.6 6.8 2.5 2.6 -1.7 2.5 0.3 1.6 2.5 2.5 2.4 1.6 2.1 2.4 0.8 -2.6 2.6
Hair/balding pattern: Pattern 3 2.8 4.1 7.2 -0.2 2.1 -1.8 2.4 0.4 1.8 2.6 2.6 1.8 1.6 2.0 2.1 2.4 -2.1 2.7
Number of live births 0.4 0.6 1.8 -0.6 -0.8 0.6 -0.7 1.0 -1.0 -0.6 -0.6 -0.7 -0.8 -0.3 -0.8 -1.4 0.8 -0.7
Forced expiratory volume in 1-second (FEV1) 8.6 28.8 40.1 -1.6 -6.1 5.9 -6.3 -2.3 -6.1 -6.2 -5.9 -5.7 -4.9 -3.8 -6.0 -4.8 6.0 -6.1
Pulse rate 0.8 1.4 4.8 2.2 0.9 -0.4 0.9 0.6 -0.1 0.7 0.8 1.3 2.0 1.8 0.8 1.3 -0.7 0.7
Happiness 1.9 2.4 4.7 -0.6 -1.5 1.8 -1.7 -1.4 -1.4 -2.0 -2.1 -1.3 -1.2 -0.5 -1.8 -0.5 1.6 -2.2
Noisy workplace 0.8 1.0 4.0 -2.0 -0.8 0.7 -0.9 -0.2 -0.6 -1.0 -0.9 -1.0 -0.6 -1.2 -0.9 -1.2 0.9 -1.0
Qualifications: A levels/AS levels or equivalent 0.7 1.6 9.4 0.7 1.0 -1.1 0.8 0.2 1.7 0.9 0.9 0.9 0.5 0.9 1.5 3.1 -1.1 1.0
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.1 0.2 0.4 0.1 -0.1 -0.4 0.0 -0.2 -0.4 -0.4 0.0 0.1 -0.1 0.0 -0.0 -0.2 -0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 1.2 0.6 -0.3 0.4 -0.2 -0.4 -0.1 -0.2 -0.2 -1.0 -0.1 -1.0 -0.5 -1.1 0.2 -0.2
Asthma 5.8 11.5 16.8 3.5 3.3 -3.2 3.4 1.6 3.6 3.5 3.4 3.8 4.1 3.8 3.0 3.5 -3.2 3.4
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.5 1.1 0.7 -1.1 1.2 -0.2 0.9 1.0 1.0 0.5 1.2 0.9 1.1 0.7 -0.7 1.1
Medication: Cholesterol lowering 6.2 9.6 14.4 1.3 3.7 -3.1 3.8 1.3 3.4 3.8 3.6 3.5 2.6 2.7 2.9 2.1 -3.5 3.6
Depression (self-reported) 0.4 0.5 1.6 1.3 -0.9 0.4 -0.5 -1.1 0.1 -0.7 -0.8 -0.3 -0.3 0.2 -0.9 -0.8 0.7 -0.8
Medication: Lansoprazole 0.5 0.6 1.4 0.0 0.6 -1.2 0.8 -0.0 1.2 0.9 0.9 0.9 0.5 0.6 0.8 0.1 -0.8 1.0
Prospective memory result 2.7 3.3 6.5 -1.1 -1.7 2.5 -1.7 -1.6 -2.4 -1.8 -1.9 -1.9 -1.1 -1.4 -2.0 -1.5 1.9 -1.9
Lung cancer (father) 0.9 1.1 5.2 0.7 -0.6 2.0 -0.5 -1.5 -2.3 -0.6 -0.6 -0.7 -0.2 0.6 -0.4 -0.7 0.8 -0.8
Illnesses of mother 1.2 1.5 2.3 0.5 -1.5 1.3 -1.3 -1.5 -0.7 -1.3 -1.3 -1.5 -0.9 -1.0 -1.4 -0.7 1.5 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 9.7 30.8 42.1 -1.9 -6.2 6.5 -6.4 -1.8 -6.5 -6.4 -6.0 -6.1 -5.2 -4.3 -6.1 -4.2 6.2 -6.2
Pulse wave Arterial Stiffness index 1.8 2.1 5.4 1.8 1.5 -1.3 1.5 -0.1 0.5 1.5 1.7 1.9 2.3 1.5 1.2 -0.2 -1.3 1.6
Impedance of arm (left) 0.5 2.5 7.2 -0.2 -1.3 1.9 -1.0 -0.5 -2.5 -0.9 -0.8 -1.9 -2.0 -1.6 -1.7 2.7 1.6 -0.8
Arm fat mass (right) 6.1 25.2 36.0 4.5 6.0 -4.5 6.0 0.6 3.6 5.9 5.9 4.9 5.9 5.0 5.5 1.2 -6.0 5.8
Trunk predicted mass 0.6 3.7 8.6 2.5 2.2 -1.2 1.9 0.4 0.6 1.7 1.7 1.7 2.9 2.5 2.1 -1.2 -2.4 1.6
Standing height 0.1 0.8 4.4 2.1 0.5 0.7 0.3 -0.3 -1.9 0.3 0.4 -0.7 0.8 0.7 0.1 1.2 -0.5 0.2
Length of working week for main job 0.4 0.4 1.7 0.9 -0.4 0.7 -0.4 -0.4 -0.6 -0.6 -0.6 -0.9 -1.3 -0.4 -0.5 -0.0 0.3 -0.6
Exposure to tobacco smoke at home 0.5 0.6 1.2 -0.8 0.6 -0.0 1.0 -0.9 -0.1 1.0 0.9 0.2 0.8 0.2 1.1 0.5 -0.7 0.9
Breastfed as a baby 3.7 4.5 8.4 1.6 2.4 -1.3 2.7 1.6 0.9 2.6 2.6 2.0 2.2 1.3 2.1 2.9 -2.2 2.6
Tense / ‘highly strung’ 12.1 20.1 28.0 -2.5 -5.0 4.8 -5.0 -3.3 -4.5 -5.1 -5.2 -4.1 -4.2 -3.5 -4.7 -3.9 5.1 -5.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.6 3.9 6.0 -1.1 -2.2 2.1 -2.0 -1.1 -2.4 -2.1 -2.2 -1.4 -1.8 -1.8 -2.2 -2.1 2.3 -2.2
Hair/balding pattern: Pattern 4 0.3 0.8 2.1 0.5 -0.9 0.2 -1.2 -1.0 -0.1 -1.1 -0.9 0.0 0.5 -1.2 -1.4 -1.4 0.8 -1.0
Birth weight of first child 4.5 8.2 13.4 2.0 3.5 -2.0 3.2 0.7 1.7 3.1 3.0 3.1 2.9 3.7 3.4 2.8 -3.3 3.0
Peak expiratory flow (PEF) 1.7 3.8 7.0 -0.2 -2.2 1.8 -2.6 -0.2 -1.6 -2.4 -2.2 -2.0 -2.0 -1.0 -2.3 -2.5 1.9 -2.3
Pulse wave reflection index 0.2 0.2 1.4 0.4 0.1 -0.7 0.3 -0.7 0.1 0.3 0.5 -0.0 0.8 -0.0 0.0 -1.2 -0.1 0.4
Ever highly irritable/argumentative for 2 days 3.1 3.7 5.2 -1.1 -2.3 2.1 -2.1 -1.6 -1.5 -2.2 -2.1 -2.0 -1.8 -1.8 -2.0 -1.7 2.0 -2.1
Loud music exposure frequency 0.9 1.0 4.1 -1.4 0.9 -1.4 0.8 1.6 2.0 0.7 0.5 1.0 -0.2 -0.3 0.8 -0.1 -0.8 0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.1 0.7 1.0 -0.4 0.8 1.0 0.4 0.9 0.9 0.6 0.6 0.5 1.1 1.5 -1.1 0.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 2.3 0.3 0.6 -0.3 0.9 1.5 0.1 0.7 0.8 0.7 0.9 0.9 0.8 0.4 -0.5 0.7
Blood clot in the leg (DVT) 1.8 2.3 4.4 -1.1 1.7 -2.1 1.5 1.4 2.0 1.5 1.2 2.0 1.1 0.5 1.7 1.4 -1.7 1.3
Medication: Paracetamol 2.6 4.4 6.5 1.4 2.5 -1.8 2.5 0.5 1.6 2.5 2.4 2.4 2.3 1.7 2.3 0.9 -2.5 2.5
Headache pain in last month 2.2 3.7 6.6 1.4 2.0 -1.8 2.1 0.8 2.3 2.0 1.8 2.5 2.2 2.6 1.9 0.7 -2.0 1.9
Medication for cholesterol, blood pressure or diabetes 2.3 3.8 6.2 -0.9 -2.4 1.8 -2.3 -0.1 -1.8 -2.3 -2.3 -2.5 -1.7 -2.4 -1.9 -0.8 2.1 -2.2
Glaucoma (self-reported) 1.6 1.9 4.1 0.4 -1.6 0.9 -1.6 -1.1 -1.3 -1.5 -1.3 -1.7 -1.1 -1.3 -2.0 -1.1 1.6 -1.4
Gout (self-reported) 0.3 0.4 0.9 -0.7 -0.3 0.6 -0.3 0.0 -0.6 -0.6 -0.9 -0.6 -0.9 -0.1 -0.4 0.9 0.4 -0.8
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.5 0.9 -0.7 1.5 -0.7 -0.7 -1.6 -0.8 -0.9 -1.1 -0.3 0.1 -1.2 -0.5 1.0 -0.9
Medication: Amlodipine 0.5 0.8 2.1 -0.7 -0.8 1.4 -0.8 -0.7 -0.8 -0.7 -0.5 -0.7 -1.0 -0.8 -0.9 -1.1 1.0 -0.5
Medication: Ventolin 100micrograms inhaler 1.8 2.3 6.2 1.6 1.3 -1.1 1.3 -0.5 0.7 1.4 1.5 1.8 2.4 2.5 1.1 1.5 -1.2 1.4
Birth weight 0.4 0.8 2.0 -0.0 1.2 -0.1 1.1 0.4 0.3 1.2 1.3 0.5 1.0 0.3 1.1 -0.5 -1.4 1.3
Chronic bronchitis/emphysema (mother) 5.8 6.8 9.7 0.8 2.9 -3.1 3.1 1.2 2.7 3.0 2.8 2.5 2.7 1.1 2.8 2.8 -3.1 2.8
High blood pressure (siblings) 7.9 11.4 16.1 1.7 3.9 -3.3 4.0 2.6 2.9 3.9 3.7 4.0 2.7 3.3 3.9 1.3 -4.0 3.8
Forced vital capacity (FVC), Best measure 7.8 28.6 49.6 -0.8 -5.7 6.5 -6.0 -2.7 -7.0 -6.1 -5.7 -6.0 -4.5 -3.9 -6.0 -3.9 5.8 -5.9
Body fat percentage 7.4 29.2 44.1 4.1 6.5 -5.0 6.6 1.5 4.1 6.6 6.5 5.3 5.6 4.6 5.8 2.6 -6.4 6.5
Leg fat percentage (right) 7.1 25.7 37.4 3.3 5.9 -5.1 6.1 2.1 4.5 6.1 6.0 5.2 5.4 4.1 5.4 2.4 -5.9 6.0
Arm fat-free mass (right) 1.8 9.4 16.1 3.4 3.5 -2.7 3.3 1.4 2.1 3.1 3.1 3.0 4.0 3.4 3.5 -0.4 -3.8 3.0
Exposure to tobacco smoke outside home 1.6 2.2 3.2 1.0 1.5 -1.3 1.7 1.3 1.3 1.7 1.7 1.6 1.0 1.8 1.6 0.0 -1.6 1.8
Comparative body size at age 10 8.4 23.2 40.1 4.4 5.3 -4.2 5.2 2.0 4.1 5.2 5.0 5.3 6.3 4.4 5.3 3.6 -5.4 5.0
Number of full brothers 0.8 1.0 1.8 0.6 1.0 -1.1 1.3 1.0 1.0 1.1 1.1 0.7 0.5 0.7 1.3 -0.5 -1.3 1.2
Worry too long after embarrassment 2.8 4.7 8.9 -1.4 -2.6 3.0 -2.1 -1.6 -2.8 -2.2 -2.0 -2.1 -1.9 -1.3 -2.3 -1.8 2.6 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.2 5.3 -1.2 -2.0 2.3 -1.3 -1.9 -2.3 -1.6 -1.7 -1.6 -2.0 -1.5 -1.5 -1.4 2.1 -1.8
Wheeze or whistling in the chest in last year 6.5 11.5 16.2 2.4 3.8 -3.4 4.0 1.3 3.9 4.0 3.7 3.5 3.6 2.9 3.4 2.2 -3.8 3.6
Number of children fathered 0.4 0.5 3.2 -1.8 0.3 -0.5 -0.1 1.2 1.0 -0.1 -0.4 -0.0 -0.4 -0.4 -0.0 -0.2 -0.5 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 3.1 -1.8 -0.5 0.9 -0.6 -1.4 -1.4 -0.5 -0.5 -1.3 -1.4 -1.5 -0.9 -0.0 0.3 -0.6
Age at first live birth 1.0 1.8 3.4 -0.1 -1.1 1.7 -1.7 -1.2 -1.8 -1.5 -1.4 -1.3 -1.5 -1.2 -1.3 0.3 1.3 -1.4
Pulse wave peak to peak time 1.8 2.1 5.0 -1.6 -1.5 1.4 -1.4 0.0 -0.6 -1.6 -1.7 -1.9 -2.2 -1.4 -1.2 0.3 1.3 -1.6
Health satisfaction 0.2 0.3 1.2 0.2 0.2 -1.0 0.3 -0.2 1.0 0.1 -0.0 0.1 0.4 -0.3 -0.4 -1.1 -0.3 0.1
Shortness of breath walking on level ground 0.5 0.6 1.8 -1.2 0.3 -1.0 0.5 1.2 1.2 0.4 0.1 0.0 -0.3 -1.4 0.3 -1.0 -0.5 0.2
Qualifications: College or University degree 0.3 0.9 3.6 -1.5 -0.8 0.7 -0.9 -0.5 0.0 -0.8 -0.6 -0.6 -1.5 -0.9 -0.1 1.9 0.8 -0.5
Eye problems/disorders: None of the above 0.1 0.2 0.9 -0.0 0.2 0.3 0.1 -0.1 0.0 0.2 0.2 1.0 0.4 0.8 0.5 -0.1 -0.3 0.3
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.3 -0.3 0.5 0.4 0.9 -0.8 -1.0 0.9 1.2 -0.5 0.6 -0.0 0.3 -0.7 -0.4 1.1
Emphysema/chronic bronchitis 1.9 2.1 4.1 1.0 1.6 -0.9 1.8 0.5 0.6 1.9 2.0 1.2 1.4 1.5 1.8 1.0 -1.5 2.0
Medication for pain relief, constipation, heartburn 3.3 5.6 9.0 -1.2 -2.4 2.1 -3.0 -1.3 -2.2 -2.8 -2.6 -2.6 -2.7 -1.9 -2.6 -2.0 2.3 -2.7
Neck or shoulder pain in last month 1.1 1.6 3.5 0.8 1.6 -0.4 1.6 -0.3 0.9 1.4 1.4 1.1 1.9 0.8 1.7 0.3 -1.7 1.3
Medication: Blood pressure 0.4 0.7 2.2 1.0 0.9 0.1 0.8 -0.9 -0.2 0.8 1.0 1.1 0.8 1.5 0.6 -0.7 -0.7 0.9
Angina (self-reported) 0.7 1.0 3.2 -0.9 -1.0 1.7 -0.6 0.4 -0.8 -0.5 -0.6 -0.9 -1.0 -1.2 -0.8 -1.8 0.9 -0.6
Migraine (self-reported) 0.1 0.1 0.4 -0.6 0.1 -0.2 0.3 0.1 0.2 0.2 0.1 0.5 -0.5 -0.0 -0.0 -0.4 0.0 0.2
Medication: Ibuprofen 0.8 1.0 1.9 1.4 0.8 -1.1 1.1 0.1 0.8 1.0 1.0 0.7 1.3 1.2 1.2 0.8 -0.8 1.0
Medication: Allopurinol 0.8 1.0 2.7 -1.4 -0.9 0.3 -0.8 0.9 -0.2 -1.1 -1.3 -1.0 -1.6 -1.2 -1.0 0.5 0.9 -1.2
Medication: Omeprazole 0.1 0.1 0.3 0.0 0.2 0.6 0.4 0.2 -0.3 0.1 0.0 0.3 0.4 0.6 0.5 0.4 -0.0 0.0
Medication: Seretide 50 evohaler 1.1 1.3 2.1 1.2 1.1 -1.4 1.1 0.9 1.5 1.1 1.0 1.1 0.5 1.1 1.2 1.4 -1.2 1.0
Mean time to correctly identify matches 0.4 0.8 3.3 -0.8 0.8 -1.2 1.1 -1.8 0.4 1.1 1.0 0.9 0.2 -0.3 0.4 0.8 -0.5 1.1
Heart disease (mother) 0.8 1.0 4.9 -2.2 -0.4 0.5 -0.7 0.6 -0.3 -0.6 -0.6 -1.4 -1.2 -1.7 -0.8 -0.9 0.4 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.9 3.5 6.8 0.4 1.8 -2.5 1.9 2.2 2.6 2.0 1.9 2.1 1.6 0.9 1.7 1.2 -2.0 1.9
Whole body fat mass 6.4 26.8 39.4 4.3 6.2 -4.7 6.3 1.3 3.8 6.2 6.1 5.0 5.7 4.7 5.6 1.9 -6.2 6.1
Leg fat mass (right) 7.0 27.2 39.2 4.1 6.2 -5.1 6.2 1.6 4.2 6.1 6.0 5.2 5.8 4.6 5.7 1.8 -6.3 6.0
Arm predicted mass (right) 2.0 10.1 17.3 3.5 3.7 -2.8 3.4 1.5 2.1 3.2 3.2 3.1 4.2 3.6 3.6 -0.2 -4.0 3.2
Pulse rate, automated reading 4.8 15.4 32.7 5.7 3.7 -3.4 3.7 2.6 2.2 3.4 3.4 4.4 5.4 5.2 3.6 3.4 -3.8 3.3
Alcohol intake frequency. 2.4 5.7 16.1 3.5 2.4 -1.9 2.4 0.3 0.9 2.3 2.2 2.6 4.0 3.1 1.8 -0.6 -2.4 2.2
Comparative height size at age 10 0.1 0.4 2.0 0.5 0.8 0.4 0.5 0.9 -0.5 0.5 0.5 -1.4 -0.1 -0.4 0.0 0.5 -0.8 0.5
Number of full sisters 5.4 6.5 10.5 -0.1 3.1 -2.0 3.2 0.5 2.3 3.1 3.1 2.6 2.2 2.1 3.2 2.1 -3.1 3.1
Suffer from ‘nerves’ 4.6 7.2 12.7 -2.9 -3.0 2.3 -2.9 -0.3 -1.3 -3.0 -3.0 -2.6 -3.6 -2.8 -2.6 -2.3 2.9 -2.9
Overall health rating 4.6 9.9 14.6 1.7 3.5 -3.6 3.8 2.6 3.3 3.4 3.2 3.3 3.8 3.3 2.9 0.5 -3.5 3.2
Chest pain or discomfort 2.4 3.5 5.5 1.3 1.9 -1.7 2.0 2.2 2.3 2.0 1.7 2.1 1.9 1.6 1.9 0.7 -2.1 1.7
Had major operations 0.7 0.8 2.5 -0.7 1.0 -0.5 1.2 1.6 0.0 1.2 1.3 0.3 -0.5 -0.4 0.6 0.2 -0.9 1.3
Age at last live birth 0.9 1.2 3.2 -1.0 -0.8 1.8 -1.1 -0.1 -1.5 -1.1 -1.1 -1.2 -1.6 -1.3 -0.7 -0.2 0.9 -1.0
Family relationship satisfaction 1.5 1.8 4.2 1.0 1.3 -0.7 1.5 0.1 1.2 1.5 1.3 1.3 1.0 1.9 1.5 2.0 -1.2 1.4
Leg pain on walking 3.6 4.5 8.4 -1.2 -1.7 2.3 -1.7 -2.9 -2.5 -1.8 -1.8 -2.5 -2.2 -2.2 -1.9 -2.9 1.8 -1.8
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 4.3 -2.1 -0.8 0.9 -0.9 -1.2 -1.1 -0.8 -0.7 -2.0 -1.4 -1.4 -0.6 -2.0 0.8 -0.7
Commuting to job workplace: Car/motor vehicle 1.4 1.6 4.5 -1.6 -1.1 1.4 -1.0 0.1 -0.5 -0.8 -0.9 -1.6 -2.1 -1.0 -1.2 -1.8 1.1 -0.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.6 -0.2 0.5 -1.2 0.6 -0.2 0.9 0.7 0.6 0.5 0.4 0.4 0.7 1.6 -0.5 0.7
Medication: Aspirin 2.0 2.6 5.0 -0.6 1.6 -1.1 2.0 1.1 1.8 2.2 2.2 1.7 1.0 1.1 1.6 1.1 -1.6 2.2
Supplements: Vitamin C 0.1 0.2 0.8 -0.4 -0.3 0.3 -0.2 0.0 -0.5 -0.3 -0.2 -0.7 -0.4 -0.9 -0.3 -0.0 0.3 -0.1
Knee pain experienced in last month 6.2 9.6 15.4 1.0 3.7 -2.5 3.9 0.7 2.8 3.9 3.6 3.5 2.6 2.9 3.8 1.6 -3.8 3.6
Hypertension (Self-reported) 3.9 11.0 16.6 2.9 3.9 -2.7 4.1 0.8 2.1 3.9 3.7 3.5 4.0 3.1 3.7 1.3 -4.0 3.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.3 0.8 -0.8 0.7 -0.8 -1.1 -0.7 -0.7 -0.6 -0.2 0.4 0.5 -0.6 -0.1 0.9 -0.6
Illnesses of father: Heart disease 0.7 1.0 6.3 -2.5 0.5 -0.9 0.7 -1.6 0.9 0.8 0.6 -0.4 -0.9 -1.0 0.4 0.3 -0.6 0.6
Illnesses of siblings: Diabetes 1.0 1.2 3.6 0.7 0.9 -1.7 1.2 -0.4 1.9 1.0 0.9 1.0 1.4 0.8 0.9 0.2 -1.1 1.1
Smoking status: Previous 1.6 2.4 4.2 -1.9 2.0 -0.8 1.8 1.8 1.6 1.9 1.7 0.7 -0.4 0.3 1.9 0.7 -2.0 1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 3.5 0.2 -0.8 1.5 -1.1 -1.1 -1.9 -1.0 -0.8 -1.7 -1.1 -0.7 -0.9 -0.5 0.7 -0.9
Whole body fat-free mass 1.2 6.9 14.1 3.5 3.0 -2.0 2.7 0.6 1.3 2.5 2.5 2.4 3.8 3.4 2.9 -0.8 -3.3 2.4
Leg fat-free mass (right) 1.8 9.4 18.8 4.3 3.5 -2.2 3.1 0.4 1.5 2.9 2.9 2.9 4.2 4.1 3.4 -0.6 -3.6 2.8
Arm fat percentage (left) 6.7 26.8 38.6 4.7 6.1 -4.6 6.2 1.0 3.6 6.2 6.2 5.2 5.8 4.8 5.5 1.9 -6.1 6.1
Average weekly red wine intake 0.1 0.1 0.3 0.2 -0.6 -0.2 -0.4 -0.5 0.5 -0.4 -0.3 -0.2 -0.2 -0.6 -0.2 0.0 0.4 -0.3
Handedness (chirality/laterality): Left-handed 3.2 3.8 6.5 1.4 2.0 -1.8 2.2 0.3 1.9 2.1 1.9 2.4 1.6 2.5 2.5 1.6 -1.9 2.0
Mood swings 6.3 11.4 15.5 -1.3 -3.7 3.7 -3.7 -1.4 -3.6 -3.8 -3.8 -3.0 -3.1 -2.8 -3.7 -3.9 3.7 -3.9
Loneliness, isolation 4.1 5.7 13.3 -0.7 -2.6 2.0 -2.5 -0.5 -2.4 -2.8 -2.9 -2.2 -1.7 -1.8 -2.8 -3.6 2.5 -2.9
Long-standing illness, disability or infirmity 2.6 4.0 6.5 0.6 2.3 -2.2 2.5 1.2 2.5 2.2 2.0 1.7 2.0 1.2 2.1 1.7 -2.4 2.1
Ever had bowel cancer screening 0.2 0.2 1.2 -0.8 -0.5 0.3 0.1 -0.7 -0.1 -0.1 -0.4 -0.2 -0.4 -1.1 -0.5 -0.5 0.3 -0.3
Diabetes diagnosed by doctor 2.1 3.5 5.4 2.0 2.1 -1.5 2.3 0.8 1.8 2.3 2.3 1.8 1.4 2.1 1.4 0.8 -2.0 2.3
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.2 3.0 -0.8 -1.0 1.3 -1.1 0.3 -0.9 -1.2 -1.2 -1.4 -1.7 -1.2 -0.8 -0.9 1.0 -1.1
Friendships satisfaction 0.2 0.3 0.5 -0.2 -0.7 0.7 -0.5 -0.2 -0.5 -0.5 -0.7 -0.5 -0.0 0.2 -0.5 0.3 0.7 -0.7
Qualifications: nursing, teaching 0.2 0.2 2.2 -0.1 0.3 -0.3 0.2 -0.0 0.4 0.2 0.2 0.5 -0.3 0.3 0.6 1.5 -0.3 0.2
Commuting to job workplace: Walk 0.2 0.3 0.6 0.2 -0.6 -0.2 -0.5 0.7 -0.8 -0.6 -0.5 0.1 -0.2 -0.6 -0.2 0.5 0.5 -0.7
Eye problems/disorders: Cataract 0.4 0.5 2.0 0.6 0.8 -0.7 0.8 1.4 0.6 0.7 0.8 0.1 0.3 -0.2 0.6 0.5 -0.8 0.8
Mouth/teeth dental problems: Mouth ulcers 1.7 2.8 8.5 -2.9 1.7 -1.6 1.6 1.8 2.2 1.7 1.7 1.2 -0.1 0.5 1.8 0.6 -1.6 1.8
Medication for cholesterol 6.3 9.6 17.0 -1.7 -3.7 2.3 -4.1 -2.5 -2.2 -3.8 -3.5 -3.1 -2.7 -2.3 -3.7 -2.2 3.7 -3.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.5 -0.4 -0.8 0.7 -0.4 -0.3 -0.6 -0.8 -1.0 -0.8 -0.5 -0.6 -0.8 -1.2 0.6 -1.1
Back pain experienced in last month 1.5 2.3 6.4 1.2 1.3 -1.2 1.5 2.5 1.7 1.2 1.2 1.4 2.0 1.6 1.7 0.8 -1.4 1.1
Mineral and other dietary supplements 0.2 0.3 1.4 1.2 -0.0 0.2 0.0 -0.7 -0.2 0.3 0.6 0.4 0.6 1.0 -0.1 -0.3 0.2 0.5
Breast cancer (self-reported) 0.6 0.7 6.8 2.6 0.2 -0.2 0.1 -0.7 0.3 0.1 0.1 0.7 1.4 0.4 -0.3 0.6 -0.1 -0.0
Asthma (self-reported) 5.3 10.6 16.0 3.6 3.1 -3.0 3.2 1.2 3.4 3.3 3.3 3.7 4.0 3.8 2.9 3.4 -3.0 3.2
Osteoporosis (self-reported) 1.5 1.8 4.1 0.3 1.3 -1.5 1.4 2.0 0.5 1.4 1.9 0.9 1.1 0.8 1.4 1.2 -1.5 1.8
Osteoarthritis (self-reported) 0.3 0.4 3.0 -0.4 0.4 0.3 0.5 -1.7 -1.0 0.4 0.2 -0.3 -0.1 -0.9 0.3 0.4 -0.4 0.1
Medication: Aspirin 0.8 1.0 2.4 -0.4 1.0 -0.5 1.3 0.7 1.1 1.5 1.5 1.1 0.5 0.6 0.8 0.5 -1.0 1.6
Medication: Gliclazide 0.3 0.4 2.7 1.7 0.6 0.1 0.5 -0.2 -0.3 0.6 0.6 0.3 0.6 0.4 -0.2 0.0 -0.4 0.5
Illnesses of father: None of the above (group 1) 2.3 2.8 8.9 1.3 -1.7 2.6 -1.8 -1.1 -3.0 -1.7 -1.4 -1.7 -0.4 -1.0 -1.5 -1.2 1.7 -1.5
Smoking status: Current 0.1 0.2 0.9 0.0 0.8 -0.3 0.6 0.2 0.9 0.5 0.3 -0.2 -0.1 -0.1 0.3 -0.4 -1.0 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 14.1 29.8 41.9 -2.5 -6.3 5.5 -6.5 -2.7 -5.2 -6.3 -6.1 -5.5 -5.5 -4.6 -6.4 -4.1 6.4 -6.2
Whole body water mass 1.2 6.8 13.8 3.4 3.0 -1.9 2.7 0.6 1.3 2.5 2.5 2.4 3.7 3.3 3.0 -0.8 -3.3 2.4
Leg predicted mass (right) 1.8 9.6 18.7 4.3 3.5 -2.2 3.1 0.5 1.5 2.9 3.0 2.9 4.2 4.2 3.4 -0.5 -3.7 2.9
Arm fat mass (left) 6.6 27.2 38.9 4.8 6.2 -4.6 6.2 0.9 3.6 6.1 6.1 5.2 6.0 5.2 5.7 1.4 -6.2 6.0
Number of self-reported non-cancer illnesses 4.1 7.2 11.2 1.8 3.0 -2.6 3.3 1.2 2.2 3.2 3.0 2.9 3.0 2.2 2.9 2.1 -2.8 3.1
Average weekly champagne plus white wine intake 0.6 0.8 4.5 -2.1 0.4 -0.5 0.6 1.4 1.0 0.5 0.3 0.4 -1.0 -0.7 0.8 -0.1 -0.5 0.4
Miserableness 3.2 5.5 9.4 -1.5 -2.3 2.7 -2.4 -0.7 -2.4 -2.6 -2.6 -2.5 -3.1 -2.0 -2.1 -2.6 2.2 -2.6
Guilty feelings 2.9 4.4 7.8 0.4 -2.5 2.3 -2.3 -0.3 -2.6 -2.3 -2.3 -1.8 -1.3 -0.6 -2.5 -2.8 2.5 -2.3
Wears glasses or contact lenses 0.3 0.3 0.9 0.2 0.6 -0.5 0.8 -0.6 0.4 0.5 0.5 0.7 0.9 -0.1 0.6 -0.1 -0.5 0.5
Ever taken oral contraceptive pill 0.3 0.3 1.6 -1.3 -0.2 -0.3 -0.2 1.2 0.3 -0.1 -0.1 -0.5 -0.5 -0.6 -0.0 -0.6 0.1 -0.1
Hearing aid user 0.8 0.9 2.1 0.3 1.1 -1.1 0.8 0.1 1.5 0.8 0.7 1.1 0.9 1.2 0.9 -0.5 -1.1 0.8
Mother’s age at death 0.1 0.2 0.6 -0.7 0.8 0.4 0.2 0.1 -0.5 0.1 -0.1 0.2 -0.1 -0.1 0.1 0.7 -0.5 -0.1
Financial situation satisfaction 0.2 0.2 0.8 -0.2 0.2 0.7 0.3 0.2 -0.2 0.2 0.0 0.9 0.0 0.9 0.5 -0.6 -0.2 0.0
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.2 0.2 0.2 -0.8 0.2 0.0 1.0 0.2 0.2 0.6 1.1 0.2 0.1 -0.5 -0.2 0.2
Commuting to job workplace: Public transport 0.6 0.8 3.7 1.9 0.6 -0.7 0.6 0.3 -0.0 0.7 0.8 1.1 1.4 0.4 0.7 0.5 -0.6 0.9
Eye problems/disorders: Glaucoma 2.0 2.3 4.2 0.7 -1.8 1.3 -1.7 -1.3 -1.8 -1.5 -1.4 -1.9 -1.1 -1.2 -2.1 -0.9 1.9 -1.5
Medication: Blood pressure 2.9 5.4 9.9 2.5 2.7 -1.4 3.2 1.1 1.1 3.0 2.8 1.9 2.9 1.9 2.5 1.1 -2.6 2.7
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.6 0.2 -0.2 0.6 0.8 -0.4 -0.1 0.7 0.6 -0.0 -0.0 0.2 0.1 -0.5 0.0 0.5
Supplements: Fish oil (including cod liver oil) 1.5 1.9 4.0 -1.7 -1.2 0.7 -1.4 -0.4 -0.7 -1.6 -2.0 -1.4 -1.5 -1.6 -1.3 -1.2 1.2 -2.0
High cholesterol (Self-reported) 7.5 13.3 18.1 2.7 3.7 -3.6 4.1 2.3 4.2 4.0 3.9 4.3 3.6 3.5 3.6 2.5 -3.7 4.0
Medication: Bendroflumethiazide 2.9 4.4 9.0 2.6 2.2 -1.1 2.5 -1.0 0.2 2.5 2.5 2.4 3.0 1.9 2.2 0.5 -2.1 2.4
Medication: Paracetamol 2.2 3.4 5.2 1.1 2.1 -2.0 2.0 1.3 1.8 2.1 1.9 2.2 2.3 1.6 1.9 0.5 -2.1 2.0
Medication: Lisinopril 0.8 1.1 2.9 1.5 0.9 -0.6 1.2 0.6 -0.1 1.1 1.1 1.2 1.1 1.7 1.0 0.4 -0.8 1.1
Medication: Atorvastatin 6.2 7.6 11.8 2.9 2.6 -2.3 3.1 2.0 2.2 3.1 3.1 3.3 2.8 3.4 2.4 1.8 -2.4 3.1
Illnesses of father: High blood pressure 1.2 1.5 3.5 -0.6 1.4 -1.7 1.5 1.3 1.9 1.3 1.1 0.8 -0.2 -0.2 1.4 -0.2 -1.6 1.1
Alcohol drinker status: Never 0.1 0.1 0.4 0.4 -0.5 -0.3 -0.2 0.1 -0.3 -0.2 -0.1 -0.0 0.6 -0.3 -0.4 -0.4 0.2 -0.2
Ever smoked 0.8 1.4 5.9 -2.4 1.2 -0.1 1.3 1.1 1.1 1.3 1.1 -0.1 -1.0 -0.7 1.2 -0.2 -1.3 1.2
Basal metabolic rate 2.0 10.8 19.4 4.0 3.9 -2.6 3.6 0.8 1.8 3.4 3.4 3.0 4.4 3.9 3.6 -0.4 -4.1 3.3
Leg fat percentage (left) 7.3 26.4 37.5 3.8 6.0 -5.1 6.1 1.8 4.5 6.1 5.9 5.4 5.6 4.5 5.4 2.2 -6.0 5.9
Arm fat-free mass (left) 1.9 9.4 15.6 3.1 3.7 -2.6 3.5 0.9 2.0 3.2 3.2 2.9 4.0 3.4 3.5 -0.5 -3.9 3.1
Number of operations (self-reported) 0.9 1.4 2.1 1.4 1.2 -0.6 1.4 1.3 0.6 1.4 1.4 1.1 1.3 1.5 0.8 -0.1 -1.2 1.3
Average weekly beer plus cider intake 0.3 0.5 1.6 -1.3 -0.6 0.6 -0.4 -0.8 -0.3 -0.6 -0.8 -0.4 -1.2 0.0 -0.6 -0.0 0.7 -0.7
Irritability 12.9 21.9 30.1 -2.5 -5.0 5.3 -5.2 -1.8 -5.5 -5.2 -5.1 -4.6 -5.1 -3.6 -4.6 -4.6 5.0 -5.2
Risk taking 0.9 1.4 3.1 -0.4 1.5 -1.0 1.4 1.4 1.7 1.3 1.1 1.2 0.0 0.6 1.1 0.9 -1.3 1.2
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.3 -0.4 -0.5 0.4 -0.5 -0.3 -0.6 -0.6 -0.9 -0.6 -0.3 -1.0 -1.1 -0.5 0.5 -0.9
Fractured/broken bones in last 5 years 5.7 7.4 12.3 1.3 2.9 -2.8 2.9 2.9 2.6 2.7 2.6 3.5 2.3 2.9 3.2 1.4 -3.0 2.6
Age started oral contraceptive pill 0.5 0.6 2.4 0.9 0.7 -0.5 0.7 -0.3 0.1 0.6 0.6 1.0 1.6 0.9 0.9 0.9 -0.6 0.6
Diastolic blood pressure, automated reading 5.3 16.5 32.4 5.7 4.2 -2.8 4.2 1.3 1.8 4.1 4.1 4.6 5.6 5.3 4.1 1.6 -4.2 3.9
Ever depressed for a whole week 2.7 3.4 5.4 -1.3 -2.3 1.4 -2.1 -1.0 -1.3 -2.2 -2.1 -1.7 -1.6 -2.0 -1.9 -1.6 2.0 -2.2
Unable to work because of sickness or disability 2.0 2.6 5.0 1.4 2.2 -1.2 2.0 -0.6 0.8 1.9 1.8 1.4 1.7 1.6 1.5 -0.2 -2.2 1.9
Commuting to job workplace: Cycle 0.3 0.4 1.6 0.2 0.4 -0.6 0.5 -0.5 0.7 0.6 0.7 0.8 0.4 -0.0 0.7 1.3 -0.4 0.8
Myopia 5.3 7.7 10.0 1.1 2.9 -2.8 3.2 3.0 2.8 3.1 3.1 3.0 2.8 2.2 2.8 2.3 -2.7 3.1
Vascular/heart problems diagnosed by doctor 3.7 10.1 14.8 -2.9 -3.7 2.7 -3.8 -1.1 -2.1 -3.8 -3.6 -3.5 -3.8 -2.9 -3.5 -0.8 3.8 -3.6
Cholesterol lowering medication 9.2 13.5 19.1 2.3 4.0 -3.2 4.4 3.3 3.3 4.2 4.0 4.0 3.6 3.1 4.0 2.5 -4.1 4.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 0.6 0.7 -0.2 0.7 -0.2 0.5 0.6 0.5 0.7 0.7 0.7 0.8 0.8 -0.5 0.5
Pain experienced in last month 8.4 14.1 20.2 -2.1 -4.2 3.0 -4.4 -2.2 -3.8 -4.3 -4.1 -4.0 -3.7 -3.7 -4.5 -2.5 4.3 -4.1
Supplements: Calcium 0.6 0.6 2.7 1.6 0.4 -0.8 0.5 -0.3 0.9 0.4 0.5 1.0 1.1 0.7 0.8 0.5 -0.6 0.5
Basal cell carcinoma (self-reported) 0.4 0.4 1.0 -1.0 -0.5 0.1 -0.7 0.2 0.2 -0.8 -0.9 -0.8 -0.9 -0.8 -0.4 -0.2 0.4 -0.9
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.0 -0.3 0.8 -0.6 0.9 0.9 1.0 1.0 1.0 0.4 -0.1 -0.0 0.9 0.8 -0.9 1.0
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 4.1 -1.2 1.7 -2.0 1.5 1.4 2.0 1.5 1.1 1.9 1.0 0.4 1.7 1.4 -1.7 1.3
Heart disease (siblings) 0.3 0.3 3.5 -0.1 -0.1 0.5 0.3 0.6 0.3 0.1 -0.1 0.3 0.2 0.4 0.0 -1.9 0.0 0.0
Alcohol drinker status: Previous 0.3 0.4 1.5 1.2 0.5 -0.3 0.6 -0.4 0.6 0.7 0.7 0.3 0.2 0.7 0.2 -0.9 -0.5 0.7
Pack years of smoking 2.6 3.8 9.0 0.5 2.0 -3.0 2.0 1.9 2.5 1.9 1.9 1.6 1.7 1.4 2.1 1.5 -2.3 1.9
Impedance of whole body 0.6 3.2 7.6 -1.1 -1.6 1.7 -1.2 -0.3 -2.1 -1.0 -0.9 -2.2 -2.6 -2.3 -1.9 2.8 1.9 -0.9
Leg fat mass (left) 7.3 28.4 41.0 4.3 6.3 -5.2 6.3 1.4 4.4 6.2 6.1 5.5 6.0 4.9 5.8 1.9 -6.4 6.0
Arm predicted mass (left) 2.2 11.1 17.9 3.2 4.0 -3.0 3.7 1.2 2.5 3.5 3.5 3.1 4.1 3.7 3.8 -0.3 -4.2 3.4