TWAS hub - STX1B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1070	0.0450	3.6e-04	0.046	NA	0.027	NA	0.057	1.1e-04	NA	2.7e-03	NA	1.9e-05
2	GTEx	Artery Aorta	0.1650	0.0530	9.5e-08	0.175	NA	0.126	NA	0.146	6.5e-10	NA	1.9e-07	NA	1.9e-08
3	GTEx	Artery Tibial	0.1336	0.0401	6.7e-07	0.114	NA	0.085	NA	0.090	3.2e-09	NA	3.3e-07	NA	1.4e-07
4	GTEx	Brain Cerebellar Hemisphere	0.1340	0.0690	8.8e-03	0.111	NA	0.047	NA	0.101	9.0e-04	NA	2.4e-02	NA	1.5e-03
5	GTEx	Brain Cerebellum	0.2360	0.0830	1.9e-05	0.156	NA	0.044	NA	0.182	2.4e-05	NA	1.9e-02	NA	4.8e-06
6	GTEx	Breast Mammary Tissue	0.0790	0.0380	1.9e-03	-0.003	NA	0.015	NA	-0.002	5.1e-01	NA	5.1e-02	NA	4.3e-01
7	GTEx	Breast Mammary Tissue (Male)	0.0738	0.0552	6.4e-02	0.095	NA	-0.001	NA	0.059	3.3e-03	NA	3.5e-01	NA	1.7e-02
8	GTEx	Cells Transformed fibroblasts	0.1200	0.0420	2.7e-07	0.099	NA	0.092	NA	0.099	6.9e-08	NA	2.2e-07	NA	6.8e-08
9	GTEx	Colon Transverse	0.1240	0.0650	5.5e-03	0.015	NA	-0.005	NA	-0.002	6.4e-02	NA	7.5e-01	NA	3.9e-01
10	GTEx	Esophagus Mucosa	0.1160	0.0590	4.1e-05	0.032	NA	0.046	NA	0.054	3.0e-03	NA	4.8e-04	NA	1.7e-04
11	GTEx	Lung	0.1164	0.0483	6.3e-04	0.030	NA	0.038	NA	0.035	2.4e-03	NA	6.0e-04	NA	1.1e-03
12	GTEx	Nerve Tibial	0.2052	0.0677	3.2e-11	0.142	NA	0.176	NA	0.157	3.0e-10	NA	1.6e-12	NA	3.2e-11
13	GTEx	Pancreas	0.2270	0.0980	1.9e-05	0.180	NA	0.105	NA	0.160	4.6e-08	NA	3.4e-05	NA	2.8e-07
14	GTEx	Prostate	0.1950	0.1040	2.0e-03	-0.012	NA	-0.011	NA	0.013	8.8e-01	NA	8.4e-01	NA	1.5e-01
15	GTEx	Skin Sun Exposed Lower leg	0.0480	0.0250	2.4e-03	0.044	NA	0.048	NA	0.044	1.6e-04	NA	7.2e-05	NA	1.5e-04
16	GTEx	Testis	0.2590	0.0780	5.3e-08	0.228	NA	0.235	NA	0.254	1.8e-10	NA	8.8e-11	NA	1.2e-11
17	GTEx	Thyroid	0.1080	0.0390	2.0e-09	0.157	NA	0.158	NA	0.158	4.5e-12	NA	3.9e-12	NA	4.2e-12
18	ROSMAP	Brain Pre-frontal Cortex	0.0767	0.0282	7.4e-10	0.101	0.066	0.089	0.079	0.095	6.6e-13	7.3e-09	1.5e-11	2.4e-10	3.0e-12
19	TCGA	Ovarian Serous Cystadenocarcinoma	0.0240	0.0190	9.5e-03	0.009	0.011	-0.001	NA	0.001	8.0e-02	5.5e-02	3.7e-01	NA	2.6e-01
20	TCGA	Prostate Adenocarcinoma	0.0418	0.0300	1.1e-04	0.030	0.037	0.033	NA	0.029	3.4e-04	9.5e-05	2.0e-04	NA	5.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Forced expiratory volume in 1-second (FEV1), predicted percentage	14.1	29.7	54.0	-2.4	-6.1	-1.5	-6.1	-5.5	-5.4	-4.6	-5.3	-4.8	-5.9	-1.4	-6.3	-6.5	-4.0	-6.5	-5.8	-7.3	-6.3	-6.9	-5.6
Irritability	12.0	20.4	37.5	-3.5	-5.3	-2.9	-5.6	-5.0	-2.0	-1.1	-4.9	-4.2	-5.1	-1.1	-5.2	-5.2	-0.4	-5.2	-5.0	-4.2	-6.1	-5.8	-5.7
Neuroticism (Nagel 2018)	11.4	26.8	40.3	-4.3	-6.3	-3.5	-6.3	-6.0	-3.1	-1.6	-5.5	-4.1	-6.1	-2.1	-5.7	-6.0	-2.5	-6.1	-6.1	-4.8	-6.2	-6.3	-6.0
Tense / ‘highly strung’	11.0	18.2	29.6	-2.8	-5.3	-2.2	-5.0	-4.6	-2.6	-0.9	-4.6	-4.1	-5.1	-2.3	-4.7	-5.0	-1.5	-5.1	-4.8	-4.8	-5.2	-5.4	-4.7
Blood Red Count	10.9	105.6	153.8	-8.2	-11.1	-7.3	-12.2	-11.3	-8.9	-4.7	-11.0	-9.4	-11.0	-5.4	-12.2	-11.3	-3.6	-11.5	-11.5	-11.6	-12.4	-11.7	-12.3
Worrier / anxious feelings	10.7	20.2	27.5	-4.0	-5.2	-3.5	-5.1	-5.1	-3.4	-3.0	-5.0	-4.1	-5.1	-2.0	-4.8	-4.9	-3.7	-5.1	-5.2	-4.4	-4.8	-4.8	-4.9
Neuroticism score	9.9	20.7	30.8	-4.1	-5.5	-3.5	-5.5	-5.3	-2.3	-1.2	-5.1	-3.9	-5.6	-2.1	-5.2	-5.2	-1.6	-5.3	-5.4	-4.1	-5.3	-5.4	-5.3
Worry (Nagel 2018)	9.6	20.2	32.3	-2.9	-5.6	-2.2	-5.4	-4.9	-2.8	-2.7	-4.8	-4.2	-5.1	-1.3	-4.8	-5.3	-3.7	-5.4	-5.1	-4.4	-5.4	-5.7	-4.9
Neuroticism	9.5	22.9	37.1	-3.8	-5.8	-3.1	-5.8	-5.5	-2.4	-1.1	-5.2	-4.0	-6.1	-2.0	-5.4	-5.7	-1.8	-5.8	-5.7	-4.3	-5.6	-5.9	-5.5
Hip circumference	9.3	39.9	89.1	-0.8	7.1	-2.0	6.6	5.2	6.1	5.4	5.8	6.7	6.7	-0.4	6.8	7.6	5.9	7.7	6.1	9.4	7.2	8.8	5.5
Alzheimer’s Disease (including proxy)	9.0	13.0	27.1	-0.4	-4.3	0.2	-3.8	-3.1	-3.0	-2.4	-3.7	-4.5	-3.6	-1.4	-4.0	-4.2	-3.4	-4.2	-3.3	-5.2	-4.3	-4.7	-3.5
Forced expiratory volume in 1-second (FEV1), Best measure	8.9	28.2	49.2	-2.5	-6.1	-1.7	-6.2	-5.5	-4.5	-3.1	-5.4	-4.4	-5.9	-0.3	-6.5	-6.4	-2.5	-6.4	-5.8	-6.8	-6.5	-7.0	-6.0
Lung FVC	8.6	43.9	70.4	-4.3	-7.6	-3.5	-7.7	-7.3	-5.8	-4.1	-6.9	-5.2	-6.9	-2.3	-7.5	-7.8	-4.3	-7.9	-7.5	-8.4	-7.6	-7.9	-7.3
Cholesterol lowering medication	8.4	12.4	21.3	1.3	4.1	0.8	3.8	3.5	3.3	2.2	3.7	3.6	4.1	2.1	3.9	4.4	1.6	4.3	3.6	4.5	4.1	4.6	3.5
Forced expiratory volume in 1-second (FEV1)	8.1	27.1	42.0	-3.4	-6.1	-2.8	-6.1	-5.8	-4.4	-3.2	-5.4	-4.1	-5.2	-1.3	-6.2	-6.3	-2.4	-6.3	-5.8	-6.1	-6.1	-6.5	-5.9
Pain experienced in last month	7.9	13.1	25.6	-1.4	-4.1	-0.9	-3.9	-3.7	-3.7	-2.0	-3.7	-3.4	-4.6	-2.1	-4.3	-4.4	-1.1	-4.4	-3.8	-5.1	-3.9	-4.5	-3.5
Waist circumference	7.8	28.6	61.2	-0.8	6.1	-2.0	5.7	4.5	4.3	4.0	5.0	6.1	5.2	-0.5	5.6	6.7	4.5	6.8	5.3	7.8	6.2	7.6	4.8
High blood pressure (siblings)	7.5	10.9	23.7	-0.1	3.6	-0.7	3.5	2.8	3.8	3.0	2.8	2.8	3.2	-0.6	3.5	4.0	3.2	4.0	3.2	4.9	3.7	4.5	3.3
Comparative body size at age 10	7.5	20.8	34.5	2.3	5.0	1.8	5.0	4.7	4.6	3.9	5.0	5.3	4.9	2.2	5.5	5.2	1.7	5.3	5.0	5.9	4.8	5.3	4.2
Depressed Affect (Nagel 2018)	7.2	15.1	24.4	-4.3	-4.9	-3.9	-4.5	-4.7	-1.8	0.3	-4.2	-2.7	-4.9	-2.3	-4.3	-4.4	-0.8	-4.4	-4.6	-3.1	-4.2	-4.1	-4.5
Illnesses of siblings	7.2	10.1	24.2	0.4	-3.2	0.9	-3.1	-2.4	-4.4	-3.8	-2.5	-2.6	-3.5	0.5	-3.3	-3.7	-2.8	-3.6	-2.7	-4.9	-3.5	-4.2	-3.0
Leg fat mass (left)	7.0	27.4	60.8	-0.9	5.8	-1.9	5.5	4.3	5.0	4.7	4.7	5.6	5.3	-0.3	5.6	6.3	4.9	6.3	5.0	7.8	6.1	7.4	4.6
Forced vital capacity (FVC)	6.9	26.5	40.3	-3.3	-6.0	-2.7	-5.9	-5.7	-5.1	-3.8	-5.1	-3.5	-5.2	-1.6	-6.1	-6.2	-3.1	-6.2	-5.8	-6.0	-5.9	-6.3	-5.7
Body fat percentage	6.9	27.1	51.7	0.3	6.3	-0.8	5.6	4.8	4.0	3.8	5.3	5.8	5.7	-0.2	5.7	6.6	4.1	6.6	5.4	7.0	5.9	7.2	4.8
Forced vital capacity (FVC), Best measure	6.8	24.9	42.3	-2.5	-5.8	-1.9	-5.7	-5.2	-5.0	-3.3	-4.9	-3.4	-5.5	-0.6	-6.1	-6.0	-2.7	-5.9	-5.3	-6.5	-5.9	-6.5	-5.5
Leg fat mass (right)	6.8	26.5	57.6	-0.8	5.7	-1.9	5.4	4.2	5.0	4.8	4.6	5.5	5.1	-0.2	5.5	6.2	5.0	6.2	4.9	7.6	5.9	7.2	4.5
Leg fat percentage (left)	6.8	24.5	48.7	-0.2	5.7	-1.2	5.3	4.3	4.3	4.3	4.8	5.3	5.0	-0.6	5.5	6.1	4.1	6.1	4.9	6.9	5.8	7.0	4.5
Nervous feelings	6.6	12.3	21.1	-1.6	-4.4	-0.9	-4.2	-3.6	-1.4	-1.5	-3.8	-3.9	-4.5	-1.0	-3.7	-4.0	-2.7	-4.2	-4.0	-3.9	-4.2	-4.6	-3.5
Leg fat percentage (right)	6.6	23.9	47.0	0.1	5.8	-0.9	5.3	4.4	4.2	4.3	4.7	5.0	4.8	-0.4	5.4	6.1	4.1	6.1	4.9	6.6	5.7	6.9	4.6
Arm fat mass (left)	6.5	26.6	61.2	-1.4	5.7	-2.5	5.3	4.0	4.5	4.3	4.6	5.9	5.4	-0.7	5.4	6.2	4.8	6.3	4.8	7.8	6.0	7.4	4.3
Mood swings	6.4	11.7	21.6	-3.6	-4.0	-3.3	-4.0	-4.0	-1.0	1.0	-3.7	-2.7	-4.6	-2.1	-3.8	-3.7	-0.0	-3.7	-3.9	-3.0	-4.0	-3.6	-4.2
Arm fat percentage (right)	6.3	24.8	54.2	-0.8	5.8	-1.8	5.2	4.1	3.8	3.7	4.7	5.6	5.4	-0.6	5.3	6.1	4.2	6.2	4.8	7.4	5.8	7.1	4.4
Knee pain experienced in last month	6.3	9.8	25.5	0.4	3.5	-0.0	3.1	2.9	3.9	2.2	3.0	2.4	3.8	0.4	3.8	3.9	2.4	3.8	3.1	5.0	3.1	4.0	2.5
Arm fat percentage (left)	6.3	25.2	53.3	-0.7	5.8	-1.8	5.3	4.2	4.0	3.9	4.8	5.9	5.3	-0.4	5.4	6.2	4.2	6.2	4.9	7.3	5.8	7.1	4.4
Medication for cholesterol	6.3	9.6	18.3	-1.1	-3.5	-0.6	-3.1	-3.3	-2.8	-1.7	-3.2	-3.0	-4.3	-2.4	-3.3	-4.1	-1.5	-4.0	-3.4	-3.9	-2.9	-3.8	-2.6
Trunk fat percentage	6.2	24.7	45.7	0.6	6.0	-0.5	5.4	4.8	3.6	3.3	5.2	5.7	5.6	0.2	5.4	6.4	3.6	6.4	5.3	6.4	5.5	6.8	4.6
Wheeze or whistling in the chest in last year	6.2	11.1	23.1	0.8	3.6	0.4	3.9	3.2	2.5	1.7	3.5	3.5	3.1	0.5	4.2	4.0	1.1	4.0	3.4	4.8	4.4	4.6	3.7
Whole body fat mass	6.2	25.8	54.5	-0.8	5.8	-1.8	5.3	4.2	4.3	4.2	4.7	5.6	5.4	-0.3	5.4	6.3	4.5	6.3	5.0	7.4	5.8	7.2	4.4
High cholesterol (Self-reported)	6.2	11.0	19.5	1.6	4.0	1.1	3.8	3.4	2.4	1.5	3.7	3.7	3.4	0.5	4.0	4.1	0.5	4.0	3.5	4.1	4.0	4.4	3.6
Body mass index (BMI)	6.0	25.8	73.0	-2.5	5.3	-3.6	4.9	3.3	5.1	5.0	3.9	5.2	4.9	-1.3	5.2	5.8	5.2	5.9	4.2	8.5	5.8	7.3	3.9
Number of incorrect matches in round	6.0	10.0	22.4	0.9	-3.5	1.6	-3.1	-2.4	-3.6	-3.5	-2.5	-2.9	-3.8	0.6	-3.3	-3.7	-2.9	-3.8	-2.9	-4.7	-3.4	-4.4	-2.7
Arm fat mass (right)	6.0	24.9	61.8	-1.6	5.5	-2.7	5.1	3.7	4.3	4.1	4.3	5.6	5.3	-0.7	5.1	6.0	4.7	6.0	4.5	7.9	5.8	7.2	4.1
Triglycerides	5.9	9.7	24.6	-0.3	3.8	-0.9	3.6	2.6	2.2	2.2	3.2	3.7	2.6	-1.0	3.7	3.8	0.2	3.8	2.9	4.1	4.1	5.0	3.0
Chronic bronchitis/emphysema (father)	5.9	6.9	12.3	1.7	2.9	1.3	3.0	2.9	2.1	1.6	2.4	1.6	3.1	0.8	3.1	3.3	1.4	3.2	3.0	3.5	3.1	3.1	3.0
Trunk fat mass	5.9	25.3	48.9	-0.3	5.8	-1.3	5.4	4.4	4.1	3.8	4.9	5.8	5.6	0.0	5.3	6.3	4.2	6.3	5.1	7.0	5.7	7.0	4.4
Chronic bronchitis/emphysema (mother)	5.9	6.9	10.1	2.2	2.9	2.0	3.1	3.0	1.7	0.2	2.8	2.0	2.9	2.1	3.2	3.1	-0.4	3.1	3.0	2.7	3.1	3.0	3.1
Cardiovascular Disease	5.7	18.9	45.8	0.0	4.9	-0.7	4.5	3.9	3.7	2.1	4.4	4.7	5.7	1.0	4.9	5.4	2.8	5.5	4.5	6.8	4.6	5.8	3.9
Relative age voice broke	5.7	8.6	12.3	2.8	3.1	2.6	3.5	3.4	2.5	2.1	3.2	2.9	2.6	2.4	2.8	3.0	3.0	3.2	3.5	1.8	3.2	3.0	3.5
Number of treatments/medications taken	5.6	10.1	16.0	2.2	3.7	1.8	3.5	3.6	2.4	1.2	3.8	3.7	2.9	2.2	3.7	4.0	0.3	3.9	3.5	3.9	3.5	3.7	3.2
Medication: Cholesterol lowering	5.5	8.5	17.4	1.0	3.6	0.5	3.5	3.1	1.3	0.6	3.1	2.7	2.6	-0.7	3.4	3.8	1.2	3.8	3.3	3.5	3.6	4.2	3.4
Number of full sisters	5.4	6.5	17.6	1.3	3.0	1.1	2.9	2.8	2.2	0.2	2.4	1.4	2.9	0.5	3.1	3.2	1.1	3.2	2.9	4.2	2.7	3.1	2.8
Asthma	5.3	10.5	18.1	2.9	3.5	2.6	3.9	3.5	1.7	0.9	3.9	4.0	2.5	2.1	4.0	3.4	-0.5	3.4	3.4	3.4	4.2	3.7	4.0
Fractured/broken bones in last 5 years	5.3	6.8	13.3	0.4	2.6	0.0	3.0	2.3	3.3	2.1	2.1	2.1	2.6	1.1	2.5	2.9	2.5	3.0	2.5	3.6	3.4	3.4	3.1
Weight	5.2	25.7	62.3	-1.7	5.4	-2.8	5.2	3.7	4.7	4.5	4.4	5.8	5.2	-0.3	5.1	6.0	5.0	6.0	4.6	7.9	5.9	7.2	4.1
Frequency of tenseness / restlessness in last 2 weeks	5.1	7.9	12.4	-2.8	-3.4	-2.5	-3.4	-3.2	-0.9	-0.0	-3.5	-3.3	-2.9	-1.2	-3.1	-3.0	-0.1	-3.0	-3.2	-2.5	-3.5	-3.2	-3.4
BMI	4.9	28.6	79.0	-2.4	5.6	-3.5	5.3	3.7	5.2	4.3	4.2	5.4	5.8	-1.1	5.6	6.2	5.0	6.3	4.7	8.9	6.2	7.8	4.2
Loneliness, isolation	4.8	6.7	14.2	-3.8	-3.0	-3.7	-2.8	-3.2	-1.5	-0.1	-3.0	-1.8	-3.1	-2.2	-2.9	-2.5	-0.3	-2.5	-3.1	-1.7	-2.3	-2.0	-2.8
Asthma (self-reported)	4.8	9.6	16.8	2.8	3.3	2.5	3.7	3.3	1.3	0.3	3.8	3.9	2.5	2.0	3.9	3.2	-1.0	3.2	3.2	3.3	4.1	3.5	3.8
Medication: Atorvastatin	4.8	6.0	11.3	1.2	3.0	0.7	2.7	2.5	0.9	0.5	3.0	3.4	2.0	0.5	2.6	3.1	-0.4	2.9	2.5	3.3	3.0	3.2	2.7
Pain all over the body in last month	4.7	5.0	8.4	1.3	2.2	1.0	2.4	2.2	2.4	2.1	2.2	2.7	2.2	2.1	2.5	2.4	1.2	2.4	2.3	2.9	2.5	2.6	2.3
Neuroticism (2016)	4.6	6.6	12.5	-2.0	-2.7	-1.6	-3.1	-3.1	-1.3	-1.5	-2.5	-2.2	-3.5	-0.4	-2.6	-3.1	-1.0	-3.2	-3.2	-2.5	-2.9	-3.0	-2.8
Hearing difficulty/problems: Yes	4.3	6.5	13.3	1.5	2.6	1.3	3.2	2.6	2.4	1.9	2.4	1.8	2.0	0.9	3.0	2.7	1.3	2.8	2.8	3.2	3.6	3.4	3.4
Birth weight of first child	4.3	7.8	14.9	2.3	3.0	2.0	3.0	3.3	2.4	1.1	3.0	2.8	3.9	1.7	2.9	3.2	0.4	3.4	3.5	3.5	2.3	2.7	2.6
Diastolic blood pressure, automated reading	4.3	13.5	30.9	-0.2	3.8	-0.8	4.1	3.0	3.0	2.2	3.9	5.6	3.7	1.3	3.8	4.2	2.3	4.3	3.4	4.7	4.8	5.1	3.8
Alzheimer’s Disease (in mother)	4.2	4.9	11.6	0.5	-2.6	1.0	-2.2	-1.7	-1.7	-1.8	-2.1	-2.7	-2.2	-0.5	-2.3	-2.7	-2.2	-2.7	-2.0	-3.4	-2.4	-3.0	-1.8
Myopia	4.2	6.1	10.0	1.8	3.0	1.4	2.7	2.8	2.1	2.2	2.8	2.3	2.0	0.7	2.8	3.2	1.2	3.1	2.8	2.7	2.5	3.0	2.6
Breastfed as a baby	4.1	5.1	8.5	2.9	2.6	2.7	2.3	2.9	1.3	0.3	2.8	2.4	1.7	2.8	2.3	2.7	0.7	2.6	2.6	1.5	1.8	1.8	2.2
Suffer from ‘nerves’	4.1	6.5	11.4	-1.6	-3.0	-1.2	-3.1	-2.7	-0.9	-1.0	-3.1	-3.4	-2.5	0.1	-2.9	-2.9	-1.1	-3.0	-2.9	-2.3	-3.3	-3.2	-2.9
Medication: Simvastatin	4.0	5.9	11.4	0.7	2.8	0.3	2.8	2.4	2.5	1.9	2.3	1.8	2.2	0.8	2.8	2.9	2.2	2.9	2.5	3.1	3.0	3.4	2.6
Overall health rating	4.0	8.7	23.7	-1.5	3.1	-2.1	3.3	2.1	1.8	1.4	2.3	2.8	3.1	0.5	3.1	3.8	0.9	3.7	2.5	4.5	4.1	4.9	3.0
Pulse rate, automated reading	3.9	12.7	29.7	2.6	3.4	2.4	4.1	3.7	3.2	2.1	4.3	5.4	2.8	2.6	3.9	3.7	-0.6	3.8	3.7	3.3	4.4	3.8	4.4
Townsend deprivation index at recruitment	3.8	5.3	14.7	0.1	2.7	-0.2	2.4	2.1	2.5	0.9	2.1	2.3	2.0	0.8	2.7	3.0	0.8	2.9	2.3	3.8	2.5	3.1	2.1
Hypertension (Self-reported)	3.8	10.7	26.3	-0.4	3.6	-1.0	3.5	2.8	2.6	1.6	3.2	3.7	3.6	1.4	3.6	4.1	2.3	4.0	3.1	5.1	3.9	4.6	3.0
Hand grip strength (left)	3.7	9.7	23.6	0.4	3.5	-0.0	3.3	2.6	3.1	2.4	3.3	4.0	3.3	-0.1	3.6	3.2	2.5	3.3	2.9	4.9	3.8	4.0	2.8
Fed-up feelings	3.6	6.5	11.1	-3.0	-3.1	-2.6	-3.1	-3.1	-0.2	1.3	-2.7	-1.3	-3.2	-0.9	-2.8	-2.9	0.3	-2.9	-3.0	-1.6	-3.0	-2.8	-3.3
Number of self-reported non-cancer illnesses	3.6	6.3	11.2	1.4	3.0	1.0	2.9	2.8	1.1	0.0	2.9	2.8	2.2	0.8	3.0	3.3	-0.8	3.2	2.8	3.0	2.9	3.3	2.6
Vascular/heart problems diagnosed by doctor	3.6	9.8	26.1	1.0	-3.4	1.6	-3.2	-2.4	-2.6	-2.1	-2.9	-3.6	-2.9	-1.1	-3.4	-3.8	-2.6	-3.8	-2.8	-5.1	-3.7	-4.6	-2.6
Leg pain on walking	3.5	4.3	9.7	-3.0	-1.9	-3.0	-2.1	-2.4	-1.4	0.1	-2.2	-1.7	-2.4	-3.1	-2.0	-1.7	0.9	-1.8	-2.1	-1.4	-2.0	-1.5	-2.4
High blood pressure	3.4	9.5	25.5	-0.8	3.2	-1.4	3.2	2.4	2.5	1.7	3.0	3.7	3.2	1.1	3.4	3.8	2.2	3.8	2.8	5.1	3.6	4.4	2.7
Respiratory disease	3.3	7.4	15.7	1.4	2.8	1.0	3.4	2.6	0.5	-0.4	3.1	3.5	2.5	1.3	3.4	2.9	-1.1	2.9	2.7	3.3	4.0	3.6	3.3
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	7.1	-2.1	-2.2	-1.9	-2.4	-2.2	-0.1	1.0	-2.2	-1.8	-2.6	-0.5	-2.1	-1.9	0.8	-2.0	-2.2	-1.8	-2.6	-2.1	-2.7
Alzheimer’s Disease (in father)	3.1	3.3	6.6	-0.5	-2.1	-0.2	-2.0	-1.7	-1.3	-0.1	-1.9	-2.4	-1.9	-1.4	-2.1	-2.2	-0.9	-2.1	-1.8	-2.6	-2.2	-2.3	-2.0
Fluid intelligence score	3.1	6.5	16.5	1.0	2.7	0.9	2.5	2.5	3.7	1.4	2.2	1.3	3.1	1.9	3.0	3.1	1.7	3.0	2.6	4.1	2.3	3.0	2.1
Hair/balding pattern: Pattern 3	3.1	4.6	7.2	2.2	2.7	2.0	2.2	2.4	2.3	1.6	2.3	1.1	2.5	1.9	2.2	2.4	1.6	2.3	2.3	2.0	2.0	2.2	2.0
Medication: Blood pressure	3.1	6.0	12.7	0.0	2.6	-0.5	2.3	2.1	2.1	2.3	2.5	3.1	2.9	1.5	2.5	3.2	1.9	3.0	2.2	3.6	2.5	3.2	1.9
Miserableness	3.0	5.3	7.7	-2.4	-2.7	-2.1	-2.7	-2.6	0.3	1.8	-2.7	-2.2	-2.5	-1.4	-2.6	-2.4	1.4	-2.4	-2.5	-1.6	-2.7	-2.5	-2.8
Guilty feelings	3.0	4.5	7.6	-2.7	-2.5	-2.5	-2.6	-2.7	-1.1	-0.5	-2.2	-1.0	-2.2	-1.0	-2.5	-2.3	-0.2	-2.4	-2.8	-1.3	-2.3	-2.1	-2.6
Sensitivity / hurt feelings	2.9	5.0	8.6	-1.5	-2.6	-1.1	-2.8	-2.6	-1.2	-1.3	-2.5	-2.1	-2.1	-0.2	-2.6	-2.7	-0.9	-2.8	-2.7	-2.1	-2.7	-2.9	-2.7
Medication for pain relief, constipation, heartburn	2.9	4.9	9.0	-1.5	-2.7	-1.3	-2.4	-2.5	-1.6	0.2	-2.6	-2.2	-2.1	-1.4	-2.6	-3.0	0.4	-2.8	-2.3	-2.7	-2.4	-2.7	-2.3
Falls in the last year	2.8	3.8	7.7	-0.1	2.4	-0.5	2.1	1.8	1.3	-0.2	2.1	2.7	2.0	0.2	2.3	2.5	0.4	2.6	2.1	2.5	2.1	2.8	1.8
Handedness (chirality/laterality): Left-handed	2.8	3.4	6.0	1.1	2.0	0.9	1.9	1.9	2.3	0.9	1.9	1.9	2.3	0.0	2.2	2.2	0.5	2.1	1.9	2.4	1.9	2.1	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.1	9.5	-1.8	-2.3	-1.5	-2.4	-2.2	-1.0	-0.8	-2.0	-1.7	-3.1	-1.8	-2.1	-2.0	-1.2	-2.1	-2.3	-1.8	-2.5	-2.3	-2.4
Medication: Bendroflumethiazide	2.7	4.0	14.5	-0.5	2.3	-1.0	1.9	1.5	1.4	0.3	2.1	2.8	1.5	0.3	2.1	2.5	1.6	2.4	1.6	3.8	2.3	2.8	1.5
Financial difficulties in last 2 years	2.6	3.5	8.5	-1.2	1.9	-1.7	1.6	1.3	1.7	1.9	1.5	2.3	1.4	0.0	1.7	2.5	1.9	2.4	1.7	2.9	1.6	2.7	1.0
Prospective memory result	2.6	3.2	7.7	-1.3	-1.9	-1.2	-1.8	-1.7	-2.8	-2.6	-1.7	-1.4	-1.6	-0.2	-1.8	-1.7	-2.3	-1.7	-1.7	-1.5	-1.7	-1.8	-1.8
Ever highly irritable/argumentative for 2 days	2.6	3.1	5.4	-1.2	-2.2	-1.0	-2.1	-2.0	-1.1	-0.7	-2.0	-1.7	-1.2	0.1	-1.9	-2.1	-0.7	-2.2	-2.2	-2.3	-2.0	-2.1	-2.1
Pack years of smoking	2.6	3.8	7.1	1.0	2.0	0.7	2.3	1.8	2.2	2.0	1.6	1.3	1.9	0.8	2.1	2.0	1.5	2.0	1.9	2.5	2.7	2.5	2.3
Arm predicted mass (left)	2.6	13.4	38.1	-2.7	3.2	-3.4	3.4	1.8	4.2	4.1	2.2	3.6	3.4	-0.5	3.2	3.7	4.7	3.9	2.7	6.2	4.4	5.3	2.6
Hand grip strength (right)	2.5	6.8	16.3	0.4	2.7	0.1	2.8	2.1	2.7	2.3	2.8	3.7	2.8	0.4	3.0	2.6	1.7	2.7	2.5	4.0	3.1	3.2	2.4
Smoking status: Previous	2.5	3.7	22.9	0.3	1.8	0.1	1.2	1.5	2.7	3.4	0.9	-0.4	2.4	-0.5	1.4	1.8	4.8	1.9	1.8	1.8	0.6	1.4	0.8
Long-standing illness, disability or infirmity	2.5	3.8	8.0	1.0	2.1	0.8	2.4	2.1	1.0	-0.4	2.0	1.6	1.7	1.4	2.4	2.5	-0.4	2.4	2.2	2.8	2.4	2.6	2.1
Ever depressed for a whole week	2.5	3.1	7.1	-1.3	-2.1	-1.0	-1.9	-2.1	-0.4	-0.4	-2.1	-1.9	-2.7	0.7	-1.7	-2.1	-1.1	-2.2	-2.2	-1.8	-1.5	-1.9	-1.5
Smoking Status	2.4	5.8	29.9	-0.6	2.0	-1.0	1.7	1.6	3.3	3.7	1.1	0.4	3.1	0.3	1.9	2.3	5.5	2.5	2.1	3.2	1.3	2.3	1.1
Leg fat-free mass (left)	2.3	12.0	37.2	-2.4	3.0	-3.1	3.1	1.7	4.0	3.9	2.3	4.1	3.2	0.3	3.1	3.5	4.1	3.6	2.5	6.1	3.9	4.8	2.3
Leg predicted mass (left)	2.3	12.1	37.6	-2.4	3.0	-3.1	3.1	1.7	4.1	4.0	2.3	4.1	3.3	0.2	3.1	3.5	4.3	3.6	2.6	6.1	3.9	4.8	2.3
Worry too long after embarrassment	2.3	3.8	6.8	-1.1	-2.2	-0.8	-2.6	-2.1	-1.3	-1.1	-2.0	-1.9	-2.2	-1.1	-2.2	-2.1	-0.3	-2.3	-2.4	-1.6	-2.6	-2.6	-2.3
Arm predicted mass (right)	2.3	11.8	33.5	-2.5	3.0	-3.1	3.1	1.7	4.3	4.2	2.1	3.7	2.8	0.1	3.0	3.4	4.3	3.5	2.5	5.8	4.0	4.8	2.4
Basal metabolic rate	2.3	12.5	37.1	-2.7	3.1	-3.5	3.2	1.7	3.9	3.8	2.2	4.0	3.3	-0.2	3.1	3.6	4.4	3.7	2.6	6.1	4.1	5.0	2.3
Arm fat-free mass (left)	2.3	11.8	33.9	-2.9	2.9	-3.6	3.1	1.6	3.9	3.9	1.9	3.4	3.2	-0.6	2.9	3.5	4.5	3.6	2.4	5.8	4.0	4.9	2.2
Crohns Disease (2017)	2.2	4.8	8.2	-2.7	-2.4	-2.5	-2.6	-2.6	-0.6	-0.8	-2.8	-2.9	-2.7	-0.6	-2.3	-2.1	-0.5	-2.2	-2.6	-0.9	-2.4	-2.0	-2.6
Past tobacco smoking	2.2	4.1	26.9	0.1	-1.8	0.3	-1.2	-1.4	-2.9	-3.4	-0.8	0.6	-2.5	0.5	-1.5	-1.9	-5.2	-2.0	-1.7	-2.1	-0.7	-1.6	-0.7
Had menopause	2.2	2.8	5.0	1.5	2.0	1.3	1.9	2.0	1.4	1.1	2.0	1.5	0.6	0.9	1.8	2.2	0.7	2.1	1.9	1.2	2.0	2.0	2.0
Allergy	2.2	5.1	11.9	-3.4	-2.0	-3.5	-2.4	-2.7	-2.2	-0.9	-2.5	-1.9	-0.9	-2.8	-2.5	-1.9	1.2	-2.0	-2.5	-1.8	-2.1	-1.5	-2.4
Medication: Paracetamol	2.2	3.6	7.8	-0.1	2.4	-0.5	2.2	1.8	1.0	0.3	2.0	2.1	2.4	-0.2	2.0	2.5	0.5	2.5	2.1	2.4	2.3	2.8	1.9
Arm fat-free mass (right)	2.2	11.2	33.3	-2.6	2.8	-3.2	3.0	1.5	4.3	4.1	1.9	3.5	2.8	0.0	2.9	3.3	4.3	3.4	2.3	5.8	3.8	4.7	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	7.5	-0.8	-1.8	-0.5	-2.2	-1.5	-0.5	-0.5	-1.4	-1.5	-2.7	-1.3	-1.7	-1.3	-0.7	-1.6	-1.8	-1.9	-2.5	-2.2	-2.2
Alcohol intake frequency.	2.2	5.2	13.2	-2.3	2.0	-3.0	2.1	0.9	1.2	2.1	1.6	3.3	2.2	0.1	1.9	2.4	0.8	2.4	1.4	3.5	3.1	3.6	1.8
Relative age of first facial hair	2.1	4.3	8.5	0.8	2.4	0.4	2.5	2.0	1.6	1.8	2.1	2.5	1.5	0.9	1.9	2.2	2.9	2.4	2.3	1.6	2.6	2.6	2.4
Alcohol intake versus 10 years previously	2.1	3.1	5.0	1.7	1.9	1.5	2.1	2.2	1.2	0.3	2.0	1.8	1.8	1.3	1.9	2.2	-0.3	2.2	2.2	1.6	1.8	1.9	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	5.0	0.6	1.9	0.5	1.9	1.6	1.7	1.2	1.5	1.1	1.5	0.8	1.9	1.9	-0.1	1.9	1.7	2.0	2.1	2.2	1.8
Unable to work because of sickness or disability	2.1	2.8	9.3	-1.4	1.7	-1.9	1.6	1.0	0.9	0.5	1.1	1.8	1.9	-0.3	1.6	2.0	0.5	2.1	1.4	3.0	1.8	2.6	1.2
Irritable Bowel Disease (IBD)	2.0	4.7	8.0	-2.6	-2.0	-2.5	-2.8	-2.5	-1.0	-1.0	-2.5	-2.5	-2.6	-1.4	-2.0	-1.9	-0.4	-2.1	-2.7	-0.5	-2.5	-2.0	-2.8
Primary Biliary Cirrhosis	2.0	2.9	9.2	0.2	1.4	-0.0	1.6	1.3	2.5	1.8	1.5	2.3	1.5	1.1	1.8	1.8	0.3	1.7	1.4	3.0	1.9	2.0	1.5
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	8.2	0.1	-2.2	0.6	-2.2	-1.7	-0.5	0.0	-1.7	-1.7	-1.3	1.0	-2.0	-2.3	-1.1	-2.4	-1.9	-2.5	-2.4	-2.9	-2.0
Leg fat-free mass (right)	2.0	10.5	35.0	-2.8	2.6	-3.4	2.8	1.4	3.8	3.6	2.0	4.0	3.1	0.1	2.8	3.1	3.9	3.2	2.2	5.9	3.5	4.4	1.9
Leg predicted mass (right)	2.0	10.7	35.3	-2.7	2.6	-3.3	2.8	1.4	3.9	3.6	2.0	4.0	3.1	0.2	2.8	3.1	4.0	3.3	2.3	5.9	3.5	4.4	1.9
Father’s age at death	1.9	2.5	5.0	0.2	-1.7	0.5	-1.8	-1.2	-1.3	-1.6	-1.4	-1.7	-1.9	-0.4	-1.7	-1.8	-1.5	-1.8	-1.5	-2.2	-1.9	-2.2	-1.6
Chest pain or discomfort	1.9	2.8	6.0	-0.3	1.7	-0.5	1.8	1.3	1.7	1.2	1.6	1.8	1.9	0.7	2.0	2.0	0.7	2.0	1.5	2.1	2.2	2.5	1.8
Family relationship satisfaction	1.9	2.4	4.9	2.1	1.5	2.2	1.5	1.8	1.5	0.5	1.8	1.4	2.2	1.9	1.5	1.5	0.6	1.5	1.6	0.4	1.2	1.1	1.7
Diabetes diagnosed by doctor	1.9	3.1	6.2	0.1	2.2	-0.3	2.0	1.6	0.4	0.7	2.0	2.4	1.6	-0.5	2.1	2.3	0.5	2.2	1.7	2.0	2.2	2.5	2.1
Illnesses of father: None of the above (group 1)	1.9	2.4	4.2	-0.6	-1.5	-0.5	-1.8	-1.5	-1.2	-1.0	-1.1	-0.0	-1.6	0.7	-1.8	-1.8	-2.0	-1.8	-1.6	-1.9	-2.0	-2.1	-2.0
Eye problems/disorders: Glaucoma	1.9	2.2	6.6	-0.4	-1.4	-0.2	-1.5	-1.4	-2.6	-1.3	-0.9	-0.3	-1.6	-1.7	-1.7	-1.7	-0.8	-1.7	-1.6	-2.5	-1.3	-1.7	-1.1
Pack years adult smoking proportion	1.8	2.8	5.6	0.7	1.7	0.4	2.0	1.5	1.9	1.8	1.4	1.3	1.6	0.7	1.8	1.8	1.2	1.7	1.6	2.3	2.4	2.2	1.9
Qualifications: A levels/AS levels or equivalent	1.8	3.9	16.7	3.8	1.2	4.1	1.4	2.1	1.1	-1.4	1.8	0.9	2.2	3.4	1.4	0.8	-2.0	0.9	1.8	-0.5	0.8	0.1	1.7
Peak expiratory flow (PEF)	1.8	4.2	7.0	-2.3	-2.4	-2.1	-2.4	-2.6	-1.4	-0.7	-2.3	-1.5	-1.2	-0.7	-2.5	-2.6	0.2	-2.5	-2.4	-2.0	-2.2	-2.1	-2.5
Headache pain in last month	1.8	3.1	7.7	-0.3	1.8	-0.5	1.9	1.4	1.5	0.3	1.6	1.8	2.7	0.2	2.0	2.1	0.0	2.1	1.6	2.8	2.3	2.5	1.8
Medication: Aspirin	1.8	2.4	4.8	0.7	2.2	0.5	1.7	1.6	1.4	0.6	1.6	0.6	0.9	-0.4	1.8	2.0	1.7	1.9	1.5	1.8	1.8	2.1	1.8
Medication: Paracetamol	1.8	2.8	6.6	-0.5	1.9	-0.8	1.9	1.3	1.4	0.8	1.5	1.6	2.0	0.3	1.7	2.0	0.6	2.1	1.7	2.3	2.3	2.6	1.8
Verbal and Numeric Reasoning (VNR)	1.7	4.0	10.7	1.1	2.0	0.9	2.1	2.1	2.8	0.9	1.6	0.8	2.2	1.5	2.5	2.5	1.1	2.4	2.2	3.3	1.8	2.3	1.8
Body Mass Index (BMI) (2010)	1.7	2.3	4.9	0.3	2.1	-0.1	1.6	1.5	1.8	1.0	1.4	0.8	1.7	-0.2	1.6	2.0	1.4	2.0	1.5	1.9	1.6	2.2	1.2
Heel T-Score	1.7	13.6	31.1	0.8	-3.9	1.6	-4.0	-2.9	-1.7	-1.9	-3.8	-5.6	-3.9	1.6	-3.9	-4.5	-1.5	-4.4	-3.3	-5.0	-4.8	-5.5	-3.7
Glaucoma (self-reported)	1.7	2.0	6.8	-0.9	-1.4	-0.8	-1.3	-1.5	-2.6	-1.5	-1.0	-0.4	-1.4	-1.3	-1.5	-1.6	-1.0	-1.6	-1.5	-2.3	-0.9	-1.4	-0.9
Emphysema/chronic bronchitis	1.7	1.9	3.5	0.5	1.9	0.2	1.5	1.4	0.8	0.6	1.5	1.5	1.7	0.6	1.6	1.8	0.8	1.7	1.5	1.8	1.5	1.7	1.3
Breast Cancer	1.6	3.7	9.5	0.5	2.5	0.2	1.9	1.8	2.1	2.0	1.8	1.0	1.9	-1.1	2.0	2.2	2.1	2.2	1.9	3.1	2.0	2.5	1.7
Lupus	1.6	2.4	14.1	1.2	0.3	1.2	1.3	0.8	-1.0	-2.7	0.8	1.5	1.1	2.9	-0.5	0.4	-3.8	0.4	0.6	-0.3	1.9	0.9	1.6
Lung FEV1/FVC ratio	1.6	7.9	21.8	-0.5	-3.1	0.2	-3.7	-2.3	0.4	0.4	-3.0	-4.4	-2.2	0.9	-3.2	-2.8	1.2	-2.9	-2.6	-2.8	-4.7	-4.2	-3.7
Medication: Ramipril	1.6	2.1	6.9	-0.2	1.6	-0.5	1.4	1.1	1.1	2.6	1.4	1.4	1.1	-0.2	1.1	1.7	1.1	1.7	1.3	1.8	1.6	2.0	1.4
Impedance of arm (right)	1.6	7.4	27.0	4.6	-0.7	4.9	-1.1	0.7	-4.0	-4.0	0.5	-0.7	-0.7	2.2	-1.4	-1.2	-3.8	-1.3	-0.2	-5.2	-2.3	-3.3	-0.6
Happiness	1.6	1.9	5.9	-0.0	-2.0	0.3	-1.3	-1.1	-1.2	-0.6	-1.4	-1.2	-1.6	0.8	-1.6	-1.7	-0.9	-1.6	-1.2	-2.4	-1.4	-1.9	-1.1
Medication: Ventolin 100micrograms inhaler	1.6	2.0	5.4	1.2	1.5	1.1	1.9	1.4	0.4	-0.1	1.7	1.7	1.0	-0.4	1.7	1.3	-0.4	1.3	1.3	1.7	2.3	1.6	2.1
Osteoporosis (self-reported)	1.6	2.0	4.6	1.1	1.7	0.8	1.6	1.4	1.6	2.1	1.1	0.9	1.3	1.5	1.1	1.4	1.1	1.4	1.3	1.2	1.6	1.5	1.5
Impedance of whole body	1.6	7.9	32.8	5.0	-0.7	5.3	-1.1	0.8	-3.8	-3.6	0.5	-0.9	-1.0	2.0	-1.4	-1.2	-3.8	-1.4	-0.1	-5.7	-2.4	-3.3	-0.5
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.0	1.0	1.1	0.8	1.5	1.2	0.9	0.5	1.4	2.0	0.4	1.9	1.4	0.9	-0.9	1.1	1.3	1.5	1.6	1.3	1.5
Diabetes (self-reported)	1.5	2.3	5.0	0.0	2.0	-0.4	1.7	1.4	0.1	0.7	1.8	2.2	0.9	-1.0	1.8	2.0	0.6	1.9	1.4	1.6	1.9	2.2	1.8
Impedance of arm (left)	1.5	7.1	26.7	4.8	-0.6	5.1	-1.0	0.9	-3.6	-3.4	0.7	-0.3	-0.7	2.6	-1.2	-1.0	-3.7	-1.1	0.1	-5.2	-2.2	-3.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.9	5.2	-2.3	-0.8	-2.3	-1.4	-1.5	-0.3	0.6	-1.7	-1.9	-0.8	-1.1	-1.4	-0.9	1.8	-0.9	-1.2	-0.0	-1.4	-0.7	-1.8
Commuting to job workplace: Car/motor vehicle	1.5	1.8	4.3	-1.8	-0.9	-1.7	-1.6	-1.4	-0.3	0.6	-1.3	-1.6	-0.5	-2.1	-1.1	-1.0	1.5	-1.1	-1.4	-0.5	-1.7	-1.0	-1.7
Whole body fat-free mass	1.5	8.7	28.7	-3.0	2.2	-3.5	2.5	1.0	3.5	3.3	1.5	3.2	2.5	-0.2	2.3	2.7	3.9	2.8	1.8	5.4	3.4	4.1	1.7
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	9.2	-0.1	1.7	-0.4	1.3	1.1	1.8	1.7	0.4	-1.1	1.6	-0.8	1.2	1.6	3.0	1.7	1.4	2.5	1.3	1.8	1.1
Whole body water mass	1.5	8.7	28.1	-2.9	2.2	-3.5	2.5	1.0	3.5	3.4	1.5	3.2	2.6	-0.2	2.3	2.7	4.0	2.8	1.8	5.3	3.4	4.1	1.7
Hypothyroidism (self reported)	1.4	3.2	10.4	-0.9	-1.7	-0.9	-1.8	-1.4	-3.2	-2.5	-1.2	-0.3	-0.7	-0.6	-1.9	-1.5	-2.5	-1.6	-1.5	-2.7	-2.0	-1.9	-2.0
Medication: Co-codamol	1.4	1.7	4.6	-1.0	1.4	-1.3	1.4	0.9	-0.2	-0.9	1.1	1.5	1.2	0.2	1.3	1.6	0.4	1.7	1.2	1.9	1.6	2.1	1.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.5	-1.5	-1.7	-1.3	-1.3	-1.6	-0.4	-0.7	-1.5	-0.6	-1.9	0.7	-1.0	-1.3	-1.7	-1.4	-1.7	-0.9	-0.9	-1.0	-1.2
Blood clot in the leg (DVT)	1.4	1.8	3.6	1.1	1.3	1.0	1.6	1.6	1.9	0.6	1.2	0.1	0.9	0.7	1.7	1.5	0.3	1.6	1.6	1.5	1.4	1.5	1.5
Depression (Nagel 2018)	1.3	1.9	4.2	-2.0	-1.5	-1.8	-1.4	-1.9	-0.3	0.2	-1.8	-1.5	-1.8	-0.4	-1.3	-1.7	-0.8	-1.6	-1.6	-0.2	-1.0	-1.0	-1.4
Impedance of leg (right)	1.3	6.4	29.6	4.4	-0.7	4.8	-1.1	0.6	-3.1	-2.9	0.0	-1.9	-1.6	1.5	-1.4	-1.2	-2.8	-1.4	-0.3	-5.4	-2.1	-3.0	-0.4
Impedance of leg (left)	1.3	6.1	27.9	4.0	-0.9	4.4	-1.2	0.4	-3.2	-3.1	-0.1	-1.7	-1.4	1.1	-1.5	-1.3	-2.9	-1.5	-0.5	-5.3	-2.3	-3.0	-0.7
Exposure to tobacco smoke outside home	1.3	1.8	4.3	-0.8	1.6	-1.2	1.3	0.8	0.8	0.3	1.0	1.4	2.1	-0.3	1.3	1.7	0.5	1.6	1.1	1.8	1.6	2.1	1.2
Number of full brothers	1.3	1.6	4.9	-1.2	1.1	-1.5	0.7	0.4	1.9	2.2	0.5	0.9	1.5	-0.1	0.7	1.3	2.2	1.2	0.5	1.7	1.0	1.6	0.6
Hearing aid user	1.3	1.4	4.2	-1.2	0.7	-1.4	0.7	0.2	1.4	2.0	0.3	0.5	2.0	-1.2	0.7	0.8	1.9	0.9	0.6	1.9	0.9	1.4	0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.8	3.6	-1.0	-1.9	-0.7	-1.3	-1.2	-1.0	-1.0	-1.5	-1.8	-0.7	-1.4	-1.5	-1.4	-0.6	-1.4	-1.2	-1.5	-1.5	-1.4	-1.6
Ever smoked	1.3	2.3	19.0	-0.7	1.1	-0.8	0.4	0.6	2.2	2.6	0.2	-1.0	1.8	-0.3	0.9	1.3	4.4	1.3	0.8	1.4	0.1	1.0	0.1
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.3	1.0	1.3	1.0	1.6	1.6	1.8	0.7	1.1	-0.0	0.8	0.8	1.6	1.5	0.3	1.6	1.6	1.4	1.4	1.5	1.5
Bipolar Disorder (2018)	1.2	1.9	7.1	1.7	1.1	1.8	1.1	1.4	2.1	0.8	1.4	1.4	-0.1	2.7	1.4	1.2	-0.3	1.1	1.2	1.3	0.9	0.7	1.1
HDL Cholesterol	1.2	2.0	6.0	0.4	-1.9	0.7	-1.7	-1.2	-0.5	-0.4	-1.2	-1.2	-2.0	1.4	-1.4	-1.8	0.2	-1.9	-1.5	-1.4	-1.6	-2.4	-1.2
Blood White Count	1.2	8.6	23.4	1.3	-2.4	2.0	-3.3	-1.6	0.2	0.7	-2.6	-4.8	-3.9	0.8	-2.8	-2.6	2.5	-2.8	-2.2	-4.6	-4.5	-4.5	-2.7
Ever had hysterectomy (womb removed)	1.2	1.4	3.7	-0.3	1.4	-0.6	1.2	0.9	1.0	0.8	0.9	1.1	1.6	0.2	1.2	1.5	0.3	1.4	0.9	1.5	1.5	1.9	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.7	-2.4	-0.9	-2.4	-1.2	-1.5	-0.6	-0.2	-1.5	-1.4	-1.5	-1.3	-1.1	-0.8	-0.1	-0.9	-1.3	0.2	-0.9	-0.4	-1.2
Taking other prescription medications	1.2	1.8	3.9	1.0	1.4	0.8	1.4	1.4	-0.1	-0.0	1.4	1.5	1.4	2.0	1.5	1.6	-0.9	1.5	1.3	1.3	1.6	1.5	1.4
Hearing difficulty/problems with background noise	1.2	2.0	3.6	1.4	1.3	1.4	1.8	1.8	0.8	0.2	1.4	1.3	1.4	0.9	1.6	1.6	0.1	1.6	1.8	1.1	1.7	1.4	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	6.8	0.0	-1.8	0.3	-1.7	-1.5	-0.3	0.0	-1.8	-2.1	-1.6	1.6	-1.9	-2.1	0.1	-2.1	-1.6	-2.6	-1.7	-2.3	-1.5
Age at first live birth	1.2	2.2	6.8	1.1	-1.3	1.4	-1.1	-0.6	-2.1	-2.1	-0.7	-0.7	-1.1	0.5	-1.5	-1.7	-1.7	-1.5	-0.6	-2.6	-1.7	-2.2	-1.1
Pulse wave peak to peak time	1.2	1.4	3.6	1.2	-1.4	1.6	-1.0	-0.6	-0.1	-0.3	-1.1	-1.7	-0.9	1.5	-1.0	-1.4	0.2	-1.4	-0.9	-1.2	-1.3	-1.9	-0.7
Neck or shoulder pain in last month	1.2	1.7	6.8	-0.3	1.2	-0.6	1.2	1.1	1.5	0.6	1.0	1.2	1.6	1.2	1.4	1.6	0.4	1.7	1.3	2.6	1.1	1.7	0.7
Back pain experienced in last month	1.2	1.8	5.0	0.5	1.1	0.3	1.3	1.2	1.5	1.0	1.2	1.5	1.5	2.2	1.6	1.5	-0.5	1.4	1.2	1.8	1.4	1.4	1.2
Intelligence (Savage-Jansen 2018)	1.1	3.4	5.4	2.2	1.9	2.1	1.8	2.3	2.3	0.5	1.7	0.8	2.1	1.7	2.1	2.0	0.7	2.0	2.3	2.3	1.3	1.5	1.7
HbA1C	1.1	1.2	5.2	0.3	0.7	0.2	1.1	0.7	0.4	0.1	1.3	1.7	0.7	-0.1	1.6	0.8	-2.3	0.8	0.7	1.2	1.5	1.2	1.5
Illnesses of mother	1.1	1.3	4.1	-0.2	-1.3	0.1	-1.3	-1.1	-1.3	-0.9	-0.7	-0.3	-1.3	0.7	-0.9	-1.3	-1.0	-1.4	-1.3	-2.0	-1.4	-1.6	-1.1
Pulse wave Arterial Stiffness index	1.1	1.3	3.4	-1.0	1.4	-1.4	1.1	0.7	0.1	0.3	1.2	1.8	0.9	-1.1	1.0	1.5	-0.2	1.5	1.0	1.1	1.3	1.9	0.7
Medication: Allopurinol	1.1	1.5	4.2	1.1	-1.1	1.4	-0.8	-0.2	-1.2	-1.5	-0.6	-1.2	-0.9	1.7	-0.8	-0.8	-2.0	-0.8	-0.4	-2.0	-1.3	-1.5	-0.8
Medication: Seretide 50 evohaler	1.1	1.3	2.3	1.3	1.0	1.2	1.3	1.3	-0.1	-1.1	1.4	1.3	0.9	0.6	1.4	1.1	-1.0	1.1	1.3	0.8	1.3	1.1	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	8.0	-1.5	-1.1	-1.5	-0.6	-1.0	-1.8	-2.8	-1.0	-0.5	0.0	-0.3	-0.6	-0.4	-2.1	-0.6	-1.0	-0.2	-0.2	-0.2	-0.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	15.6	-0.7	0.2	-0.9	0.3	-0.1	1.8	4.0	-0.0	0.2	-0.2	-0.8	0.3	0.2	2.0	0.2	-0.0	0.6	0.6	0.7	0.2
Illnesses of father: High blood pressure	1.1	1.4	3.6	-1.0	1.0	-1.2	1.0	0.7	1.4	0.7	0.5	0.2	1.4	0.1	1.2	1.5	1.9	1.5	0.9	1.8	1.1	1.7	0.8
Heart disease (siblings)	1.1	1.3	7.2	-2.5	-0.1	-2.7	-0.4	-0.9	1.0	1.8	-0.6	-0.1	0.7	-1.6	-0.2	0.3	1.2	0.1	-0.7	1.2	-0.1	0.7	-0.6
Major Depression (MDD)	1.0	1.2	3.8	-0.8	-1.1	-0.6	-1.2	-1.4	0.2	0.6	-1.1	-1.2	-2.0	0.9	-0.9	-1.5	0.5	-1.5	-1.5	-0.6	-0.9	-1.2	-1.0
Medication: Metformin	1.0	1.5	3.6	0.5	1.6	0.1	1.4	1.2	0.1	1.5	1.5	1.9	0.6	-0.2	1.4	1.4	0.8	1.5	1.4	0.8	1.3	1.4	1.3
Trunk fat-free mass	1.0	5.7	18.3	-3.0	1.5	-3.5	1.8	0.4	2.8	2.7	0.8	2.4	1.8	-0.5	1.6	1.9	3.5	2.1	1.2	4.3	2.7	3.3	1.2
Number of live births	1.0	1.4	5.7	-1.4	-0.7	-1.3	-1.0	-1.0	0.9	2.4	-0.9	-0.8	-1.1	-0.7	-1.1	-0.7	2.4	-0.7	-1.0	-0.1	-1.0	-0.6	-1.1
Noisy workplace	1.0	1.2	3.1	-1.3	-1.0	-1.3	-0.9	-1.1	-1.1	-0.8	-1.4	-1.8	-1.7	-1.2	-1.2	-0.9	0.2	-0.9	-0.9	-0.4	-0.8	-0.7	-1.1
Trunk predicted mass	1.0	5.5	17.6	-3.0	1.5	-3.5	1.8	0.4	2.8	2.8	0.8	2.3	1.8	-0.5	1.5	1.9	3.5	2.0	1.1	4.2	2.6	3.2	1.1
Illnesses of siblings: Diabetes	1.0	1.2	3.5	-0.4	1.0	-0.6	1.1	0.6	1.3	1.9	0.7	1.0	1.4	0.4	1.2	1.2	0.2	1.1	0.7	1.4	1.5	1.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.1	-0.6	-1.2	-0.5	-1.3	-1.0	0.0	0.4	-1.2	-1.1	-0.7	0.3	-1.2	-1.1	-0.1	-1.1	-1.0	-0.6	-1.8	-1.5	-1.5
Qualifications: nursing, teaching	1.0	1.6	8.6	2.1	0.3	2.1	0.3	0.9	-1.0	-2.9	0.6	0.1	1.1	2.4	0.3	0.2	-1.9	0.2	0.8	-0.6	-0.2	-0.4	0.3
Angina (self-reported)	0.9	1.1	3.6	-1.9	-0.7	-1.9	-1.3	-1.3	-0.2	-0.2	-1.0	-0.9	-0.9	-0.3	-0.9	-0.6	0.9	-0.7	-1.2	0.5	-1.2	-0.5	-1.6
Risk taking	0.9	1.3	2.6	0.6	1.2	0.4	1.5	1.3	0.7	1.0	1.0	0.5	0.9	-1.1	1.2	1.4	0.8	1.4	1.4	0.6	1.5	1.5	1.6
Bipolar Disorder or Schizophrenia	0.8	2.0	7.7	2.5	1.2	2.4	0.9	1.6	1.0	-0.3	1.6	1.6	-0.2	2.8	1.2	1.1	-1.5	1.0	1.3	0.5	0.4	0.3	0.8
Allergy or Eczema	0.8	2.2	11.2	3.2	0.5	3.4	0.9	1.6	0.8	-0.4	1.1	0.4	0.2	2.5	1.0	0.6	-2.5	0.6	1.3	0.3	0.3	-0.2	1.0
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.5	-1.1	1.4	-1.5	1.0	0.7	-0.3	0.5	1.2	2.1	0.8	-1.5	1.1	1.5	0.7	1.5	0.9	1.3	1.2	1.8	0.9
Angina	0.8	1.1	3.7	-1.9	-0.7	-1.9	-1.2	-1.3	-0.2	-0.4	-1.0	-0.9	-0.9	-0.2	-0.9	-0.6	0.6	-0.8	-1.3	0.5	-1.1	-0.4	-1.5
Supplements: Zinc	0.8	0.9	3.5	-0.4	-0.6	-0.3	-1.4	-0.8	-0.2	-0.9	-0.7	-1.0	-0.9	-0.0	-0.8	-0.8	0.3	-0.8	-0.9	-0.8	-1.9	-1.4	-1.6
Had other major operations	0.8	1.0	3.0	-0.7	0.9	-1.0	1.0	0.7	-0.0	0.3	0.7	1.0	1.7	-0.3	0.8	1.3	1.4	1.3	0.9	0.6	1.1	1.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	4.7	1.9	-0.2	2.1	0.1	0.4	-0.6	-1.6	0.2	-0.4	-1.4	1.1	-0.1	-0.4	-2.2	-0.4	0.1	-1.2	-0.2	-0.8	0.3
Birth weight	0.8	1.8	9.5	-1.1	1.2	-1.2	0.7	0.4	2.3	2.1	0.4	0.3	1.0	0.3	1.0	1.1	3.1	1.1	0.8	2.0	0.8	1.4	0.5
Qualifications: College or University degree	0.8	2.4	12.3	3.1	-0.3	3.5	-0.4	0.5	-0.0	-1.9	-0.1	-1.3	-0.3	2.8	-0.4	-0.9	-1.7	-0.8	0.1	-2.1	-1.0	-1.8	-0.0
Medication: Ibuprofen	0.8	0.9	2.0	0.7	1.0	0.7	0.9	1.0	1.2	1.2	1.2	1.4	1.0	0.5	0.9	1.1	0.8	1.0	0.8	0.6	0.8	0.9	0.8
Medication: Aspirin	0.8	1.0	2.4	0.1	1.5	-0.1	1.1	0.8	0.8	0.2	1.0	0.3	0.2	-0.6	1.1	1.3	1.3	1.2	0.8	1.1	1.3	1.6	1.2
Rheumatoid Arthritis	0.7	1.0	7.5	-0.9	-0.7	-1.0	-0.3	-0.6	-1.7	-1.2	-0.0	1.7	-0.7	0.3	-0.5	-0.5	-2.7	-0.5	-0.5	-0.3	0.0	-0.1	-0.5
Waist Hip Ratio (WHR)	0.7	3.2	13.9	0.7	-1.3	0.9	-1.3	-0.5	-3.7	-3.4	-0.4	0.1	-1.7	0.2	-1.8	-1.0	-2.5	-1.1	-0.8	-3.1	-1.9	-2.1	-1.1
Chronotype (morning person)	0.7	1.5	3.6	-1.9	-1.1	-1.9	-1.4	-1.6	-1.0	0.3	-1.1	-0.4	-0.4	-1.6	-1.2	-1.2	0.1	-1.2	-1.5	-0.9	-1.1	-0.8	-1.6
Severe depression (siblings)	0.7	0.8	8.8	0.1	-0.0	0.2	0.0	0.1	-1.2	-3.0	0.3	0.6	-0.6	-0.1	0.2	0.0	-2.1	0.0	0.0	0.6	0.0	-0.1	0.1
Hayfever, allergic rhinitis or eczema	0.7	1.6	8.0	2.6	0.1	2.8	0.2	1.1	0.7	-0.6	0.7	0.4	-0.6	2.6	0.4	0.1	-2.5	0.1	0.7	-0.3	-0.5	-0.8	0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.1	1.7	0.9	1.8	0.9	1.3	0.8	-0.9	1.2	0.8	1.4	1.6	1.0	0.8	-0.1	0.9	1.3	0.7	0.4	0.3	0.9
Heart disease (mother)	0.7	0.8	3.2	-1.0	-0.6	-1.0	-0.9	-0.8	-1.0	-0.4	-1.3	-1.8	-0.1	-1.1	-1.1	-0.7	0.3	-0.6	-0.6	-0.2	-1.2	-0.6	-1.3
Age at last live birth	0.7	1.0	2.7	0.3	-1.0	0.5	-1.1	-0.6	-0.2	-0.0	-0.9	-1.2	-0.7	0.9	-1.3	-1.1	-0.2	-1.0	-0.6	-1.3	-1.6	-1.6	-1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	4.4	2.0	0.8	2.1	0.8	1.2	-0.0	-0.4	1.0	0.2	0.7	0.3	0.8	0.6	-0.7	0.6	0.9	0.2	0.7	0.3	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	6.1	0.1	-0.6	0.3	-0.6	-0.5	-1.0	-1.9	-0.1	0.1	-1.5	0.0	-0.2	-0.8	-2.5	-0.8	-0.6	0.1	-0.5	-0.9	-0.4
Medication: Lisinopril	0.7	1.0	2.4	0.1	1.1	-0.0	0.9	0.8	0.8	0.6	1.2	1.5	0.3	-0.5	1.0	1.2	1.2	1.1	0.8	1.4	1.1	1.3	1.0
Number of operations (self-reported)	0.7	1.1	3.9	-0.7	1.2	-1.0	0.8	0.7	-0.2	-0.3	1.0	1.5	2.0	0.3	0.9	1.4	0.9	1.3	0.8	1.4	0.8	1.5	0.3
Supplements: Calcium	0.7	0.8	5.5	0.4	0.4	0.4	0.5	0.5	1.5	0.6	0.6	1.2	0.5	2.3	1.1	0.5	-0.3	0.5	0.4	1.1	0.7	0.6	0.4
Schizophrenia vs Biploar Disorder	0.6	0.8	2.1	-0.4	-0.8	-0.4	-1.0	-0.9	-1.4	-0.6	-0.8	-0.8	-0.2	-0.9	-0.9	-0.9	-0.9	-1.0	-1.0	-1.0	-1.1	-0.9	-1.1
Ulcerative Colitis (UC)	0.6	1.1	2.3	-1.0	-0.6	-1.1	-1.5	-1.1	-0.9	-0.6	-1.1	-1.2	-1.3	-1.3	-0.7	-0.7	-0.3	-1.0	-1.4	0.0	-1.4	-1.1	-1.5
Prostate Cancer	0.6	0.9	4.7	-0.3	-0.5	-0.4	-0.8	-0.6	-2.2	-2.0	-0.3	0.5	-0.5	-0.8	-0.8	-0.7	-1.7	-0.7	-0.7	-0.6	-0.7	-0.8	-0.5
Age at First Birth	0.6	0.8	3.7	0.7	-0.8	0.8	-1.0	-0.6	-0.6	0.3	-0.3	-0.3	-1.3	-0.1	-0.9	-1.0	-0.4	-1.2	-0.9	-1.9	-1.0	-1.4	-0.6
Crohns Disease (2012)	0.6	0.9	3.8	-0.8	-1.0	-0.7	-1.0	-0.8	-0.3	-1.2	-1.3	-2.0	-1.4	0.1	-0.5	-0.6	-1.1	-0.7	-1.0	0.4	-0.7	-0.7	-0.9
LDL Cholesterol	0.6	1.0	3.6	-0.8	1.1	-1.1	0.9	0.4	-0.1	-0.9	0.4	0.1	0.6	-1.9	1.0	1.1	-0.6	1.0	0.4	1.6	1.3	1.6	0.7
Ulcerative Colitis	0.6	0.8	1.9	-1.3	-0.5	-1.4	-1.1	-0.9	-0.8	-0.3	-1.0	-1.4	-0.9	-1.3	-0.2	-0.3	-0.4	-0.6	-1.2	0.7	-0.8	-0.4	-1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	5.5	0.0	0.5	-0.1	0.7	0.6	-0.6	-1.4	0.6	0.9	0.2	0.8	0.5	0.7	-2.3	0.8	0.7	0.3	0.8	1.0	0.4
Current tobacco smoking	0.6	1.0	3.5	-1.1	0.6	-1.3	0.8	0.4	0.8	0.8	0.4	0.7	1.5	0.0	0.9	1.1	1.2	1.1	0.8	1.9	0.9	1.4	0.5
Age when periods started (menarche)	0.6	1.4	10.5	2.1	-0.1	2.3	0.1	0.6	0.5	0.5	0.9	1.6	-0.1	3.2	0.0	-0.2	-1.4	-0.2	0.3	-0.8	-0.3	-0.9	0.5
Qualifications: CSEs or equivalent	0.6	0.8	6.3	-0.7	0.4	-0.8	-0.1	-0.1	1.6	1.7	0.1	0.7	-0.2	0.8	0.1	0.3	2.5	0.3	-0.0	1.3	-0.1	0.2	-0.2
Medication: Atenolol	0.6	0.7	3.2	-1.7	-0.9	-1.8	-0.6	-1.0	-0.8	-0.1	-0.9	-0.3	0.0	-1.2	-1.0	-0.7	0.5	-0.5	-0.6	-0.0	-0.5	-0.3	-0.9
Pulse rate	0.6	1.0	3.7	1.3	0.7	1.3	1.0	1.2	0.0	0.3	1.4	1.9	0.7	0.6	0.7	0.9	-0.9	0.9	1.1	-0.2	0.9	0.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.7	0.6	1.0	0.5	0.8	0.9	0.8	0.8	1.1	1.3	1.2	0.1	0.9	1.2	0.4	1.1	0.7	0.8	0.7	0.9	0.7
Exposure to tobacco smoke at home	0.6	0.7	3.4	0.3	0.9	0.2	0.6	0.7	1.1	-0.1	0.5	-0.0	1.2	0.3	0.9	1.0	1.0	0.9	0.6	1.8	0.7	0.9	0.3
Hair/balding pattern: Pattern 4	0.6	1.5	5.6	-1.8	-1.1	-1.7	-0.8	-1.4	-1.7	-1.5	-1.0	-0.3	-1.3	-0.4	-0.7	-1.2	-2.4	-1.1	-1.1	-0.8	-0.4	-0.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	6.6	-0.3	-0.9	-0.4	-0.9	-0.6	-2.6	-1.3	-0.3	0.4	-0.3	-0.8	-1.1	-0.7	-1.3	-0.7	-0.7	-2.1	-1.0	-1.0	-0.9
Breast cancer (self-reported)	0.6	0.7	3.1	0.7	0.1	0.7	0.6	0.4	-1.1	-1.3	0.9	1.8	-0.9	-0.2	0.6	0.1	-1.6	0.1	0.3	-0.4	0.8	0.2	0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.2	0.9	0.5	0.9	0.4	0.8	-0.2	-1.8	0.8	0.7	0.9	1.2	0.8	0.7	-1.2	0.7	0.8	1.1	0.2	0.3	0.3
Alcohol drinker status: Previous	0.6	0.7	3.3	-1.6	0.6	-1.8	0.2	-0.2	0.2	1.0	0.2	0.9	0.7	-0.9	0.3	0.6	1.0	0.5	0.0	1.4	0.7	1.1	0.2
Reaction Time	0.5	0.9	1.8	0.7	1.3	0.4	1.0	1.1	-0.1	0.2	1.1	0.6	0.7	-1.0	1.2	1.3	-0.4	1.2	1.1	0.9	0.9	1.1	1.1
Blood Eosinophil Count	0.5	4.2	27.9	4.8	-0.3	5.3	-0.1	1.7	-0.5	-0.2	-0.1	-3.3	-0.8	2.2	-0.2	-0.1	0.6	-0.1	1.1	-2.4	-1.4	-2.0	0.1
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.6	-1.2	-1.1	-1.1	-0.7	-1.0	0.4	0.4	-1.1	-0.6	-0.7	0.3	-0.8	-0.9	-1.0	-0.8	-0.8	-0.0	-0.5	-0.6	-0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	3.8	-0.3	-0.6	-0.3	-0.5	-0.4	-1.4	-1.9	-0.7	-0.8	-0.1	-0.3	-0.8	-0.2	-0.9	-0.3	-0.5	-1.1	-0.4	-0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.8	-0.2	-1.0	-0.0	-1.1	-1.1	-0.5	-0.4	-1.4	-1.8	-0.7	0.9	-1.2	-1.5	0.1	-1.4	-1.1	-2.0	-1.0	-1.4	-0.9
Multivitamins +/- minerals	0.5	0.6	4.2	-0.1	0.1	-0.1	0.1	0.1	2.0	1.8	-0.0	0.1	0.8	0.9	0.3	0.2	1.7	0.2	0.2	0.5	0.1	0.2	-0.1
Sitting height	0.5	3.9	9.7	-2.2	-2.3	-2.0	-1.8	-2.2	-0.8	-1.4	-2.9	-3.1	-1.9	-1.0	-2.5	-2.1	0.5	-2.0	-1.9	-1.8	-1.5	-1.6	-1.8
High blood pressure (mother)	0.5	0.7	4.4	-1.4	0.4	-1.5	0.4	-0.1	0.5	0.1	-0.3	-0.4	0.1	-1.0	0.2	0.5	0.9	0.5	0.2	2.1	0.7	1.0	0.1
Mouth/teeth dental problems	0.5	0.8	2.7	1.0	-0.8	1.3	-0.6	-0.2	-0.7	-1.5	-0.1	-0.2	-0.5	0.8	-0.6	-0.9	-1.1	-0.8	-0.4	-1.6	-0.9	-1.3	-0.4
Heart attack	0.5	0.6	1.2	0.9	1.1	0.8	0.8	1.0	0.5	0.3	0.8	0.1	0.3	1.1	0.8	1.0	0.7	1.0	0.9	0.4	0.8	0.9	0.9
Medication: Lansoprazole	0.5	0.6	2.8	-0.3	0.9	-0.4	0.7	0.4	0.3	-0.6	0.5	0.4	0.7	-0.4	0.9	0.8	-1.2	0.7	0.4	1.7	1.0	1.2	0.6
Loud music exposure frequency	0.5	0.5	2.0	-0.6	0.5	-0.7	0.6	0.4	1.1	0.7	-0.1	-0.6	0.7	0.1	0.6	0.8	0.7	0.8	0.6	1.4	0.7	1.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	5.7	0.3	0.7	0.1	0.5	0.6	1.6	2.4	0.6	0.6	-0.0	0.1	0.7	0.9	0.8	0.8	0.5	0.6	0.4	0.7	0.4
Gout (self-reported)	0.5	0.7	2.6	1.4	-0.7	1.5	-0.3	0.3	-0.7	-0.6	-0.2	-0.5	0.2	1.3	-0.5	-0.3	-0.9	-0.3	0.1	-1.6	-0.8	-1.0	-0.2
Medication: Amlodipine	0.5	0.7	2.0	-1.1	-0.6	-1.1	-0.9	-1.0	-0.6	0.3	-0.9	-0.8	-1.1	-1.4	-0.8	-0.8	0.9	-0.8	-1.0	-0.3	-0.7	-0.6	-0.8
Number of children fathered	0.5	0.6	3.7	-0.5	-0.3	-0.4	0.3	-0.1	1.2	1.6	-0.5	-1.2	0.7	0.2	0.1	-0.1	1.9	0.1	0.2	0.6	0.5	0.5	0.3
Health satisfaction	0.5	0.7	4.4	-1.9	-0.0	-2.1	0.3	-0.5	-0.4	0.5	-0.4	0.2	0.5	-1.3	-0.0	0.3	0.3	0.2	-0.3	0.1	0.9	1.1	0.3
Shortness of breath walking on level ground	0.5	0.6	3.1	-1.6	0.1	-1.8	0.0	-0.3	0.7	1.2	-0.4	-0.6	-0.2	-0.5	0.3	0.5	1.4	0.5	-0.1	0.9	0.4	0.9	0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.9	-1.0	0.9	-1.4	0.1	0.1	-0.7	-0.6	0.2	0.2	-0.1	-1.1	0.2	0.9	1.3	0.7	0.1	1.1	0.1	0.9	-0.3
Medication: Blood pressure	0.5	0.8	2.8	-1.3	0.8	-1.7	0.6	0.1	-0.1	-0.1	0.4	1.0	0.0	-1.5	0.5	0.8	1.4	0.8	0.4	1.4	0.8	1.3	0.3
Commuting to job workplace: Walk	0.5	0.6	3.7	0.7	-0.6	0.9	-0.3	-0.1	0.9	0.1	-0.2	-0.1	-1.8	1.9	-0.3	-0.5	-0.4	-0.5	-0.3	-0.6	-0.2	-0.8	0.1
Osteoarthritis (self-reported)	0.5	0.6	5.7	0.5	0.2	0.5	0.3	0.5	-1.3	-2.4	0.4	0.1	-0.5	-0.3	0.2	0.5	-1.5	0.5	0.5	-0.3	0.1	0.2	0.1
Average weekly champagne plus white wine intake	0.5	0.7	5.0	-0.2	0.4	-0.1	0.2	0.3	2.2	1.0	-0.3	-1.2	0.1	0.1	0.3	0.6	1.8	0.5	0.2	0.9	0.1	0.6	0.1
Wears glasses or contact lenses	0.5	0.5	3.0	-0.2	0.4	-0.4	0.2	0.4	1.2	1.7	0.3	0.5	0.6	0.1	0.7	0.8	1.5	0.8	0.4	0.5	0.1	0.6	-0.1
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.8	-0.6	-0.9	-0.5	-0.5	-0.5	-1.3	-1.3	-0.5	-0.4	0.1	0.2	-0.7	-0.5	-1.0	-0.5	-0.5	-1.7	-0.5	-0.4	-0.7
Commuting to job workplace: Cycle	0.5	0.7	2.7	1.6	0.8	1.6	0.6	0.9	0.7	0.0	0.8	0.4	-0.0	1.5	0.7	0.5	0.3	0.5	0.7	-0.0	0.3	0.1	0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.2	0.9	1.0	0.8	0.8	1.0	0.5	0.4	0.8	0.3	0.2	1.1	0.7	0.9	0.7	0.9	0.8	0.4	0.8	0.8	0.9
Schizophrenia (2018)	0.4	0.8	3.2	1.8	0.6	1.7	0.2	0.9	-0.4	-1.0	0.9	1.0	-0.2	1.5	0.3	0.5	-1.6	0.4	0.6	-0.5	-0.3	-0.2	0.1
Mean Putamen Volume	0.4	0.4	2.0	0.2	-0.8	0.4	-0.5	-0.1	1.1	1.4	-0.3	-0.1	-0.2	1.0	-0.5	-0.4	1.1	-0.3	-0.0	0.1	-0.9	-0.8	-0.4
Fasting Glucose	0.4	0.5	3.1	-0.5	0.3	-0.7	0.1	-0.1	0.7	1.4	-1.0	-0.8	0.4	-1.0	-0.1	0.0	1.8	0.1	0.0	0.7	0.4	0.3	0.2
Schizophrenia (2014)	0.4	1.0	4.8	2.1	0.6	2.0	0.2	0.9	0.3	-0.4	0.9	0.9	-0.2	2.2	0.3	0.4	-1.5	0.3	0.6	-0.3	-0.5	-0.5	0.1
Systolic blood pressure, automated reading	0.4	1.3	7.1	-2.6	0.0	-2.7	-0.1	-0.7	1.2	0.2	-0.3	0.3	0.0	-1.6	0.1	0.4	1.4	0.3	-0.5	1.9	0.5	1.1	-0.3
Vitamin and mineral supplements	0.4	0.5	1.8	0.4	-0.4	0.5	-0.6	-0.4	-1.3	-1.4	-0.2	-0.8	-0.8	-0.6	-0.6	-0.6	-1.0	-0.7	-0.6	-0.6	-0.7	-0.8	-0.3
Diabetes (father)	0.4	0.5	1.6	0.6	-0.5	0.8	-0.9	-0.3	0.3	0.7	0.0	0.1	-1.1	-0.1	-0.4	-0.5	-0.5	-0.6	-0.6	-1.0	-1.2	-1.1	-0.9
Diabetes (mother)	0.4	0.5	2.2	-1.2	0.8	-1.5	0.6	0.1	0.3	0.3	0.1	0.4	0.2	0.4	0.3	0.8	-0.1	0.8	0.4	1.4	0.8	1.2	0.3
Average weekly fortified wine intake	0.4	0.5	1.9	1.1	0.4	1.2	0.7	0.9	1.4	0.6	0.5	-0.0	0.4	0.8	0.8	0.5	0.3	0.6	0.9	0.1	0.4	0.3	0.7
Medication: Levothyroxine sodium	0.4	0.6	4.3	-0.1	-0.5	-0.2	-0.4	-0.3	-2.1	-1.2	-0.0	0.7	-0.4	-0.6	-0.7	-0.4	-1.3	-0.4	-0.3	-1.5	-0.5	-0.5	-0.4
Qualifications: None of the above	0.4	0.9	5.0	-1.7	-0.2	-2.0	-0.1	-0.7	0.1	2.2	-0.2	0.6	-1.0	-1.7	-0.0	0.1	0.2	-0.0	-0.6	0.5	0.6	0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	3.6	-1.9	-0.4	-1.9	-0.3	-0.4	1.4	1.3	-0.5	0.1	-0.0	0.5	0.2	0.4	0.9	0.3	-0.2	1.2	-0.3	0.4	-0.5
Depression (self-reported)	0.4	0.4	1.8	-0.8	-0.8	-0.7	-0.6	-0.8	-0.3	0.0	-0.4	0.5	-0.7	-1.3	-0.3	-0.5	-1.2	-0.6	-0.9	-0.2	-0.3	-0.3	-0.5
Lung cancer (father)	0.4	0.4	1.3	-0.6	-0.9	-0.5	-0.9	-0.6	-0.6	-0.3	-0.3	0.2	-0.2	1.0	-0.7	-0.5	-0.3	-0.5	-0.7	-0.1	-1.2	-1.1	-1.0
Pulse wave reflection index	0.4	0.5	3.8	-1.7	0.2	-2.0	-0.2	-0.5	0.1	0.5	-0.2	0.3	-0.0	-0.8	-0.2	0.3	0.1	0.2	-0.3	0.8	0.1	0.7	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.1	0.1	-0.5	0.3	-0.4	-0.4	-0.5	-0.4	-0.6	-1.4	-1.0	-1.4	-0.7	-0.6	0.8	-0.6	-0.4	-1.1	-0.5	-0.6	-0.4
Medication: Omeprazole	0.4	0.5	3.7	0.5	0.0	0.6	-0.1	0.4	-0.4	-1.9	0.3	0.1	0.7	1.2	0.1	0.4	-1.1	0.3	0.3	0.7	-0.4	-0.2	-0.2
Mean time to correctly identify matches	0.4	0.7	1.5	0.8	1.1	0.5	0.8	1.0	-1.0	-0.2	0.8	0.2	0.1	-1.2	0.9	1.1	-1.2	1.0	0.8	0.0	0.8	0.8	1.0
Had major operations	0.4	0.5	1.4	-0.1	1.2	-0.4	0.5	0.7	0.0	-0.5	0.5	0.1	0.3	-0.1	0.4	1.2	0.7	1.1	0.8	1.0	0.3	1.0	0.3
Illnesses of father: Heart disease	0.4	0.5	3.2	0.1	0.7	0.1	0.4	0.5	-0.9	-1.8	0.1	-1.3	0.8	-0.9	0.6	0.7	0.4	0.6	0.5	0.5	0.4	0.7	0.4
Age started oral contraceptive pill	0.4	0.5	1.0	0.9	0.7	1.0	0.7	0.8	0.7	0.0	0.9	0.9	0.1	0.5	0.8	0.7	-0.9	0.7	0.8	0.7	0.7	0.5	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	0.1	-0.8	0.4	-0.7	-0.4	1.0	0.9	-0.8	-1.1	-0.1	0.3	-0.4	-0.7	0.8	-0.6	-0.4	-0.5	-0.9	-0.9	-0.7
Ovarian Cancer	0.3	0.4	1.5	1.2	0.0	1.2	-0.3	0.3	-1.1	-0.8	0.2	-0.4	-0.3	-0.4	-0.3	-0.1	-1.1	-0.2	0.0	-0.7	-0.6	-0.6	-0.4
Blood Platelet Count	0.3	3.5	27.6	0.0	0.4	0.5	-0.4	0.1	5.2	2.3	-1.1	-3.7	0.0	0.7	0.5	0.4	3.6	0.2	-0.1	2.7	-0.7	-0.0	-0.4
Average weekly spirits intake	0.3	0.4	1.1	0.0	0.4	-0.0	0.8	0.5	0.4	0.8	0.6	0.7	0.3	-0.0	0.8	0.6	-0.0	0.6	0.6	0.6	1.0	0.9	1.0
Maternal smoking around birth	0.3	0.4	1.7	-0.8	-0.7	-0.7	0.0	-0.3	0.9	1.2	-0.7	-0.6	0.3	-0.9	-0.1	-0.1	1.3	-0.0	-0.0	0.3	0.1	0.1	-0.0
Supplements: Glucosamine	0.3	0.3	1.8	0.8	0.0	1.0	-0.2	0.2	0.0	-1.4	-0.2	-1.3	0.3	0.5	0.1	-0.2	0.1	-0.2	0.2	-0.6	-0.6	-0.5	-0.5
Alcohol usually taken with meals	0.3	0.4	2.0	1.1	0.4	1.1	0.7	0.5	0.1	-0.6	0.3	-0.1	0.1	1.4	0.5	0.1	-0.7	0.2	0.5	0.1	0.7	0.3	0.9
Time employed in main current job	0.3	0.3	1.1	0.4	0.6	0.3	0.4	0.4	-0.4	-0.8	0.7	0.8	0.6	0.7	0.4	0.4	-1.1	0.4	0.4	-0.3	0.4	0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.7	-0.4	-0.9	-0.3	-0.9	-0.9	-0.8	-1.0	-0.9	-0.4	-1.3	0.4	-0.9	-1.1	-0.5	-1.0	-0.8	-0.6	-0.9	-1.1	-0.9
Eye problems/disorders: Cataract	0.3	0.3	0.6	0.4	0.8	0.3	0.5	0.7	0.0	-0.1	0.6	0.8	0.7	0.6	0.4	0.8	0.3	0.8	0.7	-0.2	0.3	0.6	0.6
Medication: Gliclazide	0.3	0.4	2.0	-0.2	0.5	-0.4	0.4	0.3	-0.9	0.4	0.8	1.4	0.3	-1.1	0.4	0.5	-0.2	0.6	0.4	-0.7	0.4	0.5	0.6
Smoking status: Current	0.3	0.5	1.5	-1.1	0.3	-1.2	0.5	0.1	0.6	0.6	0.1	0.3	1.1	0.3	0.5	0.6	1.1	0.7	0.4	1.2	0.7	1.0	0.3
Financial situation satisfaction	0.3	0.4	2.1	-1.0	-0.0	-1.1	-0.1	-0.2	1.3	0.8	-0.1	-0.0	0.2	-0.7	0.1	0.3	1.4	0.3	-0.1	0.7	-0.0	0.5	-0.3
Commuting to job workplace: Public transport	0.3	0.4	2.3	0.4	0.8	0.3	0.6	0.6	0.6	0.2	0.9	1.5	-0.0	0.6	0.6	0.6	-0.3	0.6	0.6	0.5	0.5	0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.4	0.6	0.0	0.6	0.5	0.3	0.0	1.2	0.2	0.3	-0.4	0.2	0.1	-0.0	1.0	0.1	0.4	-1.0	0.4	0.1	0.6
Height	0.2	3.9	15.7	1.9	2.1	1.6	2.0	2.1	0.5	1.9	2.7	4.0	1.6	1.8	1.4	1.9	2.1	1.9	2.0	0.1	1.9	1.4	1.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	0.1	0.8	0.0	0.3	0.5	-0.1	-0.8	0.6	0.5	0.7	-0.1	0.6	0.8	0.1	0.7	0.5	0.3	0.2	0.4	0.4
Medication for hormone replacement therapy	0.2	0.3	1.1	0.6	0.2	0.6	0.1	0.5	-0.4	-0.6	0.2	-0.2	0.9	1.0	0.0	0.5	-1.0	0.5	0.4	-0.6	-0.2	0.1	-0.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	-0.2	0.5	-0.3	0.3	0.3	0.7	0.3	0.4	0.5	0.9	0.4	0.6	0.6	0.0	0.5	0.3	0.8	0.4	0.7	0.1
Serious illness, injury or assault to yourself	0.2	0.2	1.1	-1.0	-0.1	-1.1	0.0	-0.3	0.1	-0.7	-0.2	0.2	-0.1	-0.1	-0.0	0.2	-0.9	0.2	-0.1	0.7	0.1	0.3	-0.2
Stomach or abdominal pain in last month	0.2	0.3	2.4	-0.0	-0.1	0.0	-0.3	-0.0	-0.2	-1.5	-0.2	-0.7	0.4	0.3	0.0	0.2	-1.5	0.0	-0.2	0.6	-0.3	-0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.7	-0.2	-0.4	-0.0	0.0	-0.1	0.1	-1.0	-0.2	0.0	0.8	1.3	-0.1	-0.4	-0.8	-0.2	0.1	0.2	-0.1	-0.2	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.4	2.2	-1.4	-0.3	-1.5	-0.4	-0.7	-1.0	-0.7	-0.4	0.2	-0.4	-0.1	-0.4	-0.2	-0.2	-0.3	-0.6	0.5	-0.1	0.2	-0.6
Length of working week for main job	0.2	0.2	1.3	0.0	-0.6	0.1	-0.4	-0.3	0.3	1.1	-0.2	0.4	-1.0	-0.4	-0.5	-0.4	-0.0	-0.4	-0.3	-0.5	-0.4	-0.6	-0.3
Eye problems/disorders: None of the above	0.2	0.2	1.9	-0.2	0.2	-0.1	0.1	0.1	1.4	0.7	0.1	-0.0	0.2	0.6	0.4	0.1	0.1	0.2	0.2	1.2	-0.1	0.2	-0.2
Migraine (self-reported)	0.2	0.3	2.4	-0.7	0.1	-0.8	-0.0	-0.1	-0.8	-0.9	-0.2	-0.3	-0.7	-1.6	0.1	0.3	0.2	0.2	-0.1	-0.0	0.1	0.3	0.2
Supplements: Vitamin C	0.2	0.2	1.2	0.2	-0.1	0.2	-0.3	-0.1	-0.5	-0.8	-0.3	-0.4	-1.1	0.1	-0.5	-0.2	0.1	-0.2	-0.2	-1.1	-0.5	-0.4	-0.3
Ever had bowel cancer screening	0.2	0.2	0.8	-0.5	-0.4	-0.4	-0.5	-0.3	0.6	0.9	-0.3	-0.5	-0.9	0.2	0.1	0.1	0.4	-0.1	-0.5	-0.3	-0.5	-0.2	-0.4
Friendships satisfaction	0.2	0.3	0.9	0.7	-0.6	0.9	-0.5	-0.2	0.2	0.1	-0.1	-0.3	0.0	0.9	-0.3	-0.5	0.1	-0.6	-0.4	-1.0	-0.7	-0.9	-0.5
Ever taken oral contraceptive pill	0.2	0.2	1.0	-0.8	-0.1	-0.9	-0.3	-0.4	0.2	0.6	-0.6	-0.9	0.1	-0.6	-0.3	-0.2	1.0	-0.2	-0.3	0.2	-0.2	0.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.1	-0.7	0.4	-0.8	-0.1	-0.0	0.6	-0.1	0.4	0.4	0.0	0.1	0.5	0.8	-0.4	0.4	-0.3	1.0	0.3	0.6	-0.0
Average weekly beer plus cider intake	0.2	0.4	1.2	0.2	-0.7	0.3	-0.5	-0.3	-0.7	-0.4	-0.6	-0.9	-0.3	-0.8	-0.7	-0.4	-0.2	-0.5	-0.4	-1.1	-0.7	-0.7	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.4	-0.5	0.9
Coronary Artery Disease (CAD)	0.1	0.2	1.5	-0.3	-0.1	-0.3	0.0	0.0	-0.2	-0.2	-0.5	-1.0	-0.0	-0.2	0.0	0.0	1.2	0.1	0.2	0.4	-0.0	-0.0	-0.1
Systolic Blood Pressure	0.1	0.6	3.2	-1.8	-0.3	-1.7	-0.5	-0.7	1.0	-0.2	-0.2	0.5	0.1	-0.3	0.0	0.1	0.7	-0.0	-0.6	1.6	-0.3	0.3	-0.7
Hair Pigment	0.1	1.5	4.9	-0.0	-1.3	0.2	-1.3	-1.0	-1.3	-0.9	-0.9	-1.0	-2.2	-1.2	-1.1	-1.3	-1.1	-1.3	-1.2	-1.7	-1.4	-1.7	-0.9
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	0.4	-0.3	0.5	0.1	0.3	0.0	-0.5	0.2	0.4	0.4	-0.7	0.1	0.1	-0.7	0.1	0.2	-0.2	0.0	-0.2	0.4
Standing height	0.1	0.9	4.9	1.4	0.3	1.4	0.6	0.8	-0.6	-0.7	1.0	1.6	0.5	2.2	-0.1	0.3	-0.1	0.4	0.8	-1.1	0.3	-0.2	0.4
Comparative height size at age 10	0.1	0.4	1.1	0.4	0.5	0.3	0.6	0.6	-1.1	-0.9	0.5	0.6	0.9	0.9	0.2	0.5	0.6	0.6	0.7	-0.2	0.5	0.4	0.3
Average weekly red wine intake	0.1	0.2	1.5	0.2	-0.3	0.3	-0.2	-0.3	-0.4	-0.5	-0.2	-0.1	0.2	0.6	-0.1	-0.4	-1.2	-0.4	-0.4	-0.8	0.1	-0.3	0.1
Mineral and other dietary supplements	0.1	0.1	0.6	-0.4	0.4	-0.6	0.1	-0.2	-0.4	0.3	0.2	0.8	-0.3	-0.5	0.0	0.0	0.2	0.0	-0.1	0.5	0.4	0.4	0.3
Mother’s age at death	0.1	0.2	0.8	0.6	0.0	0.6	0.4	0.6	-0.4	-0.3	0.0	-0.2	-0.1	-0.9	-0.0	0.2	-0.5	0.4	0.8	-0.5	-0.1	0.0	0.2
Alcohol drinker status: Never	0.1	0.1	0.8	-0.6	-0.2	-0.6	-0.0	-0.5	0.1	0.1	-0.2	0.1	-0.2	-0.1	-0.1	-0.2	-0.9	-0.3	-0.5	-0.3	0.5	0.2	0.3
Tanning	0.0	0.5	2.6	1.4	-0.0	1.6	0.3	0.6	0.4	-0.7	0.4	0.1	0.8	1.5	0.2	0.0	-0.6	0.1	0.5	-0.1	0.2	-0.3	0.4

Hub : Genes

STX1B

Models

Trait associations