TWAS hub - C19orf54

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0220	8.9e-04	0.023	0.022	0.020	0.023	0.016	6.7e-04	9.2e-04	1.6e-03	0.00066	3.6e-03
2	GTEx	Adipose Subcutaneous	0.2210	0.0480	3.8e-09	0.054	NA	0.072	NA	0.090	3.2e-05	NA	1.7e-06	NA	8.0e-08
3	GTEx	Adipose Visceral Omentum	0.1910	0.0640	7.0e-04	0.034	NA	0.058	NA	0.009	7.1e-03	NA	5.8e-04	NA	1.1e-01
4	GTEx	Artery Aorta	0.2940	0.0650	5.9e-07	0.152	NA	0.083	NA	0.119	1.0e-08	NA	2.4e-05	NA	4.3e-07
5	GTEx	Artery Tibial	0.1204	0.0388	3.0e-04	0.127	NA	0.079	NA	0.099	3.8e-10	NA	8.6e-07	NA	3.4e-08
6	GTEx	Esophagus Muscularis	0.1470	0.0440	1.1e-04	0.153	NA	0.057	NA	0.127	1.4e-09	NA	2.3e-04	NA	4.1e-08
7	GTEx	Muscle Skeletal	0.1139	0.0331	7.7e-05	0.009	NA	0.005	NA	0.013	3.9e-02	NA	9.1e-02	NA	1.7e-02
8	GTEx	Nerve Tibial	0.2063	0.0466	2.6e-08	0.060	NA	0.101	NA	0.097	4.3e-05	NA	1.2e-07	NA	2.2e-07
9	GTEx	Pancreas	0.1400	0.0540	4.1e-03	0.079	NA	0.074	NA	0.064	3.2e-04	NA	4.9e-04	NA	1.1e-03
10	GTEx	Prostate	0.4800	0.0920	7.7e-06	0.203	NA	0.248	NA	0.265	7.9e-06	NA	6.5e-07	NA	2.4e-07
11	GTEx	Spleen	0.3600	0.1220	5.5e-03	0.241	NA	0.143	NA	0.193	7.2e-07	NA	1.7e-04	NA	1.1e-05
12	GTEx	Stomach	0.1840	0.0590	4.3e-04	0.095	NA	0.096	NA	0.105	2.6e-05	NA	2.4e-05	NA	1.1e-05
13	GTEx	Thyroid	0.2560	0.0510	4.2e-10	0.089	NA	0.194	NA	0.139	2.5e-07	NA	8.0e-15	NA	8.2e-11
14	GTEx	Whole Blood	0.1040	0.0360	8.4e-04	0.068	NA	0.059	NA	0.071	6.7e-07	NA	4.0e-06	NA	4.4e-07
15	TCGA	Colon Adenocarcinoma	0.0630	0.0360	4.4e-03	0.000	0.004	0.002	NA	0.006	3.3e-01	1.8e-01	2.3e-01	NA	1.4e-01
16	TCGA	Brain Lower Grade Glioma	0.0569	0.0275	1.0e-04	0.033	0.038	0.024	NA	0.023	1.1e-04	3.7e-05	9.0e-04	NA	9.8e-04
17	TCGA	Lung Squamous Cell Carcinoma	0.0379	0.0205	3.3e-03	0.030	0.018	0.009	NA	0.024	2.2e-04	3.8e-03	2.8e-02	NA	8.5e-04
18	TCGA	Prostate Adenocarcinoma	0.0588	0.0360	4.1e-03	0.054	0.016	0.028	NA	0.045	2.4e-06	7.8e-03	6.0e-04	NA	1.5e-05
19	TCGA	Thyroid Carcinoma	0.0620	0.0300	1.7e-03	0.025	0.026	0.023	NA	0.016	1.6e-03	1.4e-03	2.2e-03	NA	9.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Pain experienced in last month	6.4	10.6	18.3	2.7	3.6	4.3	3.7	3.2	3.3	2.8	3.1	3.3	3.4	3.6	3.3	3.3	3.3	-0.0	3.2	3.7	2.9	3.2
Current tobacco smoking	6.3	10.3	16.6	2.6	4.1	4.1	3.6	3.3	3.4	3.0	3.4	2.5	3.2	3.4	2.9	3.1	3.2	-0.6	2.3	3.9	3.1	3.8
Respiratory disease	4.9	10.9	14.4	-3.3	-3.8	-3.5	-3.0	-3.5	-3.4	-3.0	-3.8	-3.7	-3.5	-3.1	-3.4	-3.2	-3.7	1.0	-3.5	-3.5	-3.1	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.7	5.5	9.3	-2.3	-2.9	-2.5	-2.3	-2.2	-2.5	-2.9	-2.6	-2.1	-2.3	-2.6	-2.5	-2.0	-2.2	-0.2	-1.1	-2.4	-2.4	-3.0
Smoking status: Current	4.4	6.9	11.5	2.3	3.4	3.2	2.9	2.6	2.7	2.4	2.9	2.0	2.5	2.7	2.3	2.8	2.6	-0.9	2.1	3.2	2.5	3.0
Serious illness, injury or assault to yourself	3.7	4.5	7.3	1.5	2.1	1.3	2.1	2.4	2.7	2.2	1.4	1.7	2.5	2.6	2.7	2.2	2.3	-0.9	2.0	1.9	2.7	2.0
Asthma	3.7	7.2	11.6	-3.2	-3.4	-2.8	-1.9	-2.6	-2.5	-2.7	-3.1	-3.2	-2.7	-2.6	-2.5	-3.2	-2.6	2.0	-3.4	-2.1	-2.2	-1.6
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.5	7.7	-2.7	-2.6	-2.7	-2.2	-2.0	-2.3	-1.1	-1.8	-1.9	-1.9	-1.9	-2.4	-1.8	-2.2	0.0	-1.9	-2.8	-2.1	-2.2
Asthma (self-reported)	3.5	7.0	11.3	-3.0	-3.4	-2.9	-1.8	-2.6	-2.5	-2.5	-3.1	-3.2	-2.7	-2.5	-2.4	-3.0	-2.6	1.8	-3.3	-2.2	-2.2	-1.8
Alcohol intake versus 10 years previously	3.4	5.0	9.4	2.2	1.6	2.4	1.5	2.5	2.4	1.9	1.4	2.4	2.5	2.8	2.2	1.6	2.6	-0.8	3.1	2.8	2.2	2.4
Mouth/teeth dental problems: Dentures	3.4	5.7	9.3	2.1	2.5	1.2	2.6	2.8	2.8	2.6	2.2	2.6	2.7	2.8	2.7	3.1	2.6	-1.2	2.1	1.0	2.9	1.2
Medication: Allopurinol	3.1	4.1	10.5	1.0	2.0	2.6	1.6	1.9	2.1	1.8	1.7	1.1	1.9	1.9	2.2	1.5	2.1	-0.1	2.7	3.2	1.9	2.8
Commuting to job workplace: Walk	3.1	3.3	12.6	3.5	2.2	1.7	1.4	1.5	1.4	1.4	1.2	2.1	1.4	1.3	1.9	2.7	1.2	-1.8	2.7	0.9	1.2	0.5
Blood White Count	2.9	21.8	32.7	5.2	5.7	3.5	4.3	4.6	4.9	4.8	5.2	5.0	4.9	4.8	4.8	5.1	4.7	-3.7	5.5	3.5	4.7	3.0
Maternal smoking around birth	2.9	4.2	8.4	1.8	2.9	1.2	1.7	2.0	2.2	2.2	1.9	2.5	2.0	2.1	2.0	2.1	2.0	-0.9	2.3	2.5	2.0	1.9
Pain all over the body in last month	2.9	3.1	9.9	-0.6	-1.2	-3.1	-2.1	-1.9	-1.8	-1.1	-0.5	-1.5	-1.8	-1.2	-2.3	-0.4	-1.7	-1.2	-1.6	-2.5	-1.8	-2.6
Gout (self-reported)	2.9	4.0	9.4	1.0	1.9	2.0	1.9	2.1	2.2	1.7	1.9	1.0	2.1	2.2	2.2	1.2	2.3	0.4	2.1	3.1	2.1	2.9
Reaction Time	2.8	5.3	12.4	2.2	3.0	1.3	1.8	2.1	2.3	2.8	2.7	2.4	2.3	2.1	1.9	3.5	2.3	-2.6	2.4	1.2	2.2	0.9
Lung FEV1/FVC ratio	2.8	14.4	37.6	1.6	4.6	6.1	3.4	3.7	3.8	2.1	4.8	3.5	3.5	4.2	4.2	3.9	3.8	0.4	2.9	4.5	3.4	3.8
Family relationship satisfaction	2.8	3.4	7.7	0.8	0.4	-0.3	2.2	2.3	2.2	2.2	1.3	1.4	2.1	2.3	1.7	0.7	2.4	1.0	1.2	2.5	2.4	2.8
Ever had prostate specific antigen (PSA) test	2.7	3.1	6.7	-0.1	2.0	2.3	2.6	1.7	2.1	0.7	1.7	1.6	1.6	1.7	2.4	0.8	1.7	1.4	0.6	1.8	2.2	2.1
Pack years adult smoking proportion	2.6	4.0	16.9	-0.4	-1.1	-1.7	-1.9	-1.9	-1.8	-1.1	-1.4	-1.8	-1.6	-1.7	-2.1	0.0	-2.5	-1.9	-0.5	-4.1	-1.6	-3.9
Had menopause	2.5	3.1	4.8	-1.4	-1.5	-0.9	-2.2	-2.1	-2.0	-1.5	-1.4	-2.0	-2.1	-1.8	-2.0	-1.0	-2.2	-0.5	-1.4	-1.9	-2.1	-2.0
Headache pain in last month	2.5	4.3	8.1	-1.2	-2.2	-1.0	-2.2	-2.6	-2.2	-2.0	-2.0	-2.2	-2.6	-2.8	-2.0	-2.6	-2.6	-0.2	-1.1	-1.6	-2.2	-1.6
Medication: Ibuprofen	2.5	3.0	6.6	-2.3	-2.2	-2.4	-1.6	-1.6	-1.7	-0.7	-1.4	-1.6	-1.5	-1.4	-1.8	-1.4	-1.8	0.3	-2.0	-2.6	-1.4	-1.8
Pack years of smoking	2.5	3.7	17.3	0.0	-0.9	-1.6	-1.9	-1.8	-1.6	-1.1	-1.2	-1.6	-1.5	-1.6	-1.9	0.2	-2.4	-2.0	-0.5	-4.2	-1.5	-3.8
Irritable Bowel Disease (IBD)	2.4	5.8	23.1	-0.7	3.3	4.8	2.0	2.6	2.2	0.4	2.1	3.4	2.5	2.7	2.6	2.0	2.5	0.9	0.9	1.8	2.0	1.7
Supplements: Zinc	2.2	2.4	4.6	1.4	2.0	1.0	1.8	1.7	2.0	0.8	1.4	2.0	1.5	1.7	2.1	1.4	1.6	-0.2	0.9	1.3	2.1	1.0
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	8.4	-1.5	-0.5	0.0	-1.8	-2.6	-1.9	-1.9	-0.8	-1.9	-2.5	-2.6	-1.9	-0.1	-2.9	-0.6	-1.9	-2.5	-2.0	-2.4
Emphysema/chronic bronchitis	2.2	2.4	4.2	-1.5	-1.3	-1.8	-1.5	-1.7	-1.7	-1.3	-1.8	-1.2	-1.6	-1.8	-1.5	-1.4	-1.8	0.0	-1.4	-2.1	-1.6	-1.8
Mean time to correctly identify matches	2.2	4.1	10.3	2.3	2.9	1.2	1.2	1.7	1.9	2.1	2.7	2.1	1.8	2.0	1.7	3.2	1.9	-2.4	2.1	1.0	1.8	0.7
HDL Cholesterol	2.1	3.6	6.2	-0.2	-2.2	-1.4	-2.3	-1.9	-2.5	-1.8	-2.0	-1.8	-2.1	-1.8	-2.0	-2.2	-2.2	-0.8	-0.7	-1.4	-2.5	-2.2
Mouth/teeth dental problems	2.1	3.2	8.2	-1.6	-2.3	-1.6	-1.6	-1.9	-1.8	-2.5	-2.1	-1.5	-2.1	-1.9	-1.4	-2.9	-1.8	1.0	-1.4	-0.2	-1.6	-0.9
Illnesses of siblings: Diabetes	2.1	2.6	6.4	2.5	1.8	0.8	1.3	1.6	1.6	2.3	1.7	1.5	1.9	1.8	1.5	2.1	1.7	-1.1	1.1	-0.4	1.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	5.8	-0.8	-1.0	-0.8	-2.4	-1.5	-1.9	-1.7	-1.3	-1.4	-1.6	-1.7	-1.6	-0.9	-1.5	-0.2	-1.5	-1.5	-2.0	-1.9
Crohns Disease (2017)	2.0	4.3	17.3	0.5	3.4	4.2	1.5	2.2	1.8	0.6	2.2	2.8	2.2	2.2	2.1	2.2	2.1	-0.1	1.0	1.2	1.5	1.2
Number of live births	2.0	2.8	6.6	-1.2	-2.6	-2.3	-1.4	-1.4	-1.7	-2.2	-2.4	-1.7	-1.4	-1.4	-1.2	-2.2	-1.6	1.0	-1.3	-1.3	-1.6	-1.0
Medication: Ventolin 100micrograms inhaler	2.0	2.5	5.1	-1.7	-2.0	-1.2	-1.2	-1.5	-1.5	-1.4	-2.3	-1.6	-1.4	-1.4	-1.5	-1.6	-1.6	0.9	-1.9	-2.1	-1.4	-1.4
Medication: Atorvastatin	2.0	2.5	5.2	0.1	1.6	1.5	2.0	1.9	1.6	1.2	0.9	1.5	1.7	2.1	1.6	1.1	1.9	0.0	1.6	2.3	1.5	1.6
Average weekly beer plus cider intake	2.0	2.9	5.6	1.8	2.2	1.9	1.6	1.4	1.9	1.9	1.1	1.2	1.3	1.2	2.1	1.5	1.7	-1.0	1.9	2.4	1.8	1.6
Mean Putamen Volume	1.9	2.2	3.4	1.8	1.8	1.8	1.9	1.0	1.6	0.8	1.7	1.5	1.1	0.9	1.8	1.8	1.1	-0.1	1.5	1.7	1.4	1.5
Medication: Paracetamol	1.9	3.1	9.6	-2.3	-2.9	-3.1	-1.2	-1.2	-1.6	-1.4	-1.8	-1.3	-1.3	-1.2	-1.3	-2.5	-1.5	0.4	-1.1	-2.2	-1.3	-1.6
Financial situation satisfaction	1.9	2.4	4.5	-2.1	-1.9	-0.8	-1.6	-1.5	-1.5	-2.1	-1.9	-1.5	-1.8	-1.2	-1.2	-1.8	-1.3	1.2	-1.9	-0.7	-1.5	-0.9
Irritability	1.9	3.2	7.4	2.2	1.4	0.7	2.3	1.5	2.2	1.8	0.5	1.7	1.4	1.7	2.4	1.5	1.7	-0.7	2.1	2.7	2.1	1.7
Commuting to job workplace: Cycle	1.9	2.3	4.8	-0.4	-1.4	-0.5	-1.6	-1.8	-1.8	-0.5	-1.7	-1.2	-1.9	-2.2	-1.7	-1.0	-2.0	-1.2	-0.5	-1.5	-1.8	-1.9
Schizophrenia vs Biploar Disorder	1.8	2.4	6.1	1.4	1.6	1.5	2.1	1.7	1.7	0.6	1.2	2.5	1.6	1.5	2.5	1.2	1.6	-0.6	1.6	0.9	1.7	0.6
Medication for hormone replacement therapy	1.7	1.9	5.4	1.0	2.0	2.0	1.2	1.0	1.0	1.1	2.3	1.0	1.0	1.0	1.3	1.9	1.2	-1.3	1.3	1.4	0.9	1.1
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.8	-0.1	-0.1	1.4	1.7	1.6	1.4	0.4	0.3	0.9	1.6	1.2	1.5	0.1	1.6	1.5	1.1	2.1	1.4	2.2
Medication: Lansoprazole	1.7	2.0	5.6	0.4	0.9	0.2	2.1	1.5	2.2	0.6	1.3	2.1	1.6	1.5	1.9	1.2	1.3	0.6	0.7	0.2	2.4	0.7
Medication: Blood pressure	1.7	3.0	5.9	1.9	0.6	0.3	1.7	2.2	1.6	2.4	1.0	1.3	2.2	2.1	1.4	0.5	2.4	-0.2	2.0	2.2	1.6	2.2
Medication: Aspirin	1.7	2.3	5.9	1.4	1.3	0.0	1.3	1.8	1.4	2.4	1.7	1.0	2.1	1.9	0.8	2.0	1.9	-1.0	1.8	-0.0	1.5	0.3
Medication: Lisinopril	1.7	2.2	4.9	0.5	1.3	2.2	1.7	1.8	1.6	0.5	1.3	1.5	1.6	1.5	1.5	1.0	1.9	0.7	0.6	2.1	1.6	1.4
Hand grip strength (right)	1.6	4.4	9.4	-1.0	-2.4	-0.5	-2.6	-2.1	-2.6	-1.3	-1.5	-2.2	-2.1	-2.5	-3.1	-2.5	-2.3	0.4	-2.2	-2.2	-2.6	-1.5
Medication: Cholesterol lowering	1.6	2.5	6.0	0.6	0.7	0.0	1.5	2.4	1.6	1.4	0.8	2.0	2.2	2.4	1.8	0.4	2.5	0.5	1.4	1.3	1.8	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	9.3	1.4	1.2	3.0	1.6	2.2	1.7	0.8	1.4	1.8	2.1	2.3	1.6	0.6	2.1	1.4	0.9	2.2	1.6	2.8
Medication: Paracetamol	1.6	2.4	7.8	-1.6	-2.6	-2.8	-0.9	-1.1	-1.3	-1.1	-1.5	-1.4	-1.1	-1.1	-1.2	-2.1	-1.5	0.1	-0.9	-2.3	-1.0	-1.5
Myopia	1.6	2.3	5.8	-0.8	-1.6	-1.3	-1.5	-1.4	-1.4	-1.8	-2.4	-2.0	-1.6	-2.0	-1.4	-1.3	-1.6	1.0	-1.1	-1.2	-1.2	-1.3
Ulcerative Colitis	1.5	2.1	4.3	-1.4	1.5	1.4	1.6	1.5	1.6	0.3	0.6	2.1	1.6	1.4	2.0	0.5	1.5	1.4	0.7	1.9	1.6	1.7
Stomach or abdominal pain in last month	1.5	1.9	5.0	2.1	2.2	1.4	1.2	0.7	1.3	1.8	1.2	0.3	0.8	0.2	1.1	2.0	0.9	-1.9	1.8	1.0	1.1	0.6
High blood pressure (mother)	1.5	2.1	5.3	-0.6	-1.3	-1.4	-1.6	-1.8	-1.7	-0.9	-1.3	-2.2	-1.7	-2.3	-2.0	-1.6	-1.6	0.1	-0.5	0.0	-1.8	-0.5
Average weekly red wine intake	1.5	2.1	10.6	-1.2	-1.8	-3.3	-1.4	-1.4	-1.3	-0.8	-0.7	-1.8	-1.2	-1.3	-1.6	-1.3	-1.4	0.2	-1.4	-1.5	-1.1	-0.9
Ever had bowel cancer screening	1.5	1.8	3.9	-0.1	-0.8	-1.9	-1.6	-1.6	-1.4	-0.1	-1.2	-1.6	-1.5	-1.7	-1.5	-0.3	-1.5	-1.1	-0.1	-1.4	-1.4	-2.0
Wears glasses or contact lenses	1.5	1.7	3.7	-0.6	-1.8	-1.6	-1.5	-1.5	-1.2	-0.7	-1.7	-1.8	-1.5	-1.4	-0.8	-1.9	-1.5	0.7	-1.1	-0.4	-1.1	-0.3
Intelligence (Savage-Jansen 2018)	1.4	4.3	9.2	2.3	2.0	1.9	1.9	2.2	1.8	2.3	2.5	2.2	2.2	2.3	1.3	2.2	2.2	-1.9	3.0	1.2	1.6	1.2
Alzheimer’s Disease (in father)	1.4	1.5	4.3	-0.3	1.0	2.1	1.3	1.2	1.2	0.0	-0.2	1.3	1.2	1.2	1.4	0.8	1.2	1.2	0.7	1.5	1.2	1.9
Blood clot in the leg (DVT)	1.4	1.9	5.6	-1.8	-1.9	-1.5	-1.2	-0.8	-0.8	-0.8	-2.4	-2.2	-0.8	-0.3	-1.4	-1.7	-0.8	1.2	-1.9	-0.8	-0.7	-0.5
Glaucoma (self-reported)	1.4	1.6	4.5	-0.3	-0.2	1.4	1.5	1.5	1.1	0.2	0.7	0.8	1.4	1.2	1.2	-0.6	1.8	1.8	-0.1	2.0	1.1	2.1
Smoking status: Previous	1.4	2.1	11.7	-0.6	-1.1	-2.1	-1.9	-0.9	-1.5	-1.2	-0.2	-0.2	-0.9	-0.6	-0.9	-0.7	-1.3	-0.7	-1.3	-3.4	-1.3	-2.4
Friendships satisfaction	1.4	1.7	3.9	1.1	0.9	0.4	1.6	1.4	1.6	0.6	0.9	1.1	1.3	1.7	1.7	0.7	1.5	1.0	0.2	2.0	1.6	1.9
Medication: Aspirin	1.4	1.8	5.2	1.4	1.2	0.1	1.1	1.6	1.2	2.3	1.4	1.1	1.9	1.6	0.6	1.8	1.6	-1.1	1.7	-0.3	1.2	0.1
Deep venous thrombosis (DVT) (self-reported)	1.4	1.9	5.1	-1.9	-2.0	-1.5	-1.2	-0.7	-0.8	-0.8	-2.3	-2.1	-0.7	-0.2	-1.4	-1.7	-0.8	1.4	-1.9	-0.9	-0.7	-0.4
Ulcerative Colitis (UC)	1.3	2.4	8.5	-1.1	1.9	2.9	1.4	1.6	1.5	0.1	1.2	2.3	1.7	1.7	1.7	0.9	1.6	1.2	0.5	1.2	1.4	1.3
Type 2 Diabetes (T2D) (2012)	1.3	1.5	8.3	-1.1	-0.4	-0.0	-0.9	-0.6	-1.3	-1.3	-0.6	-0.3	-0.6	-0.9	-1.0	-0.3	-1.0	0.0	-1.6	-2.9	-1.2	-2.5
Chronotype (morning person)	1.3	3.0	11.2	-0.9	-1.8	-3.3	-1.8	-1.7	-1.7	-0.4	-1.8	-1.7	-1.6	-1.6	-1.8	-1.4	-1.5	-0.5	-1.5	-2.0	-1.4	-2.2
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.3	0.1	-0.8	-1.1	-2.1	-1.8	-1.7	-0.3	-0.4	-1.7	-1.7	-1.5	-1.4	-0.6	-1.9	-1.4	-0.3	-1.0	-1.8	-0.7
Systolic blood pressure, automated reading	1.3	3.8	8.0	2.5	2.1	1.9	1.8	1.7	1.9	1.8	2.1	1.9	1.9	1.8	1.8	2.0	1.9	-0.9	2.8	2.1	1.7	1.6
Supplements: Glucosamine	1.2	1.6	3.0	-1.0	-1.5	-1.6	-1.5	-1.6	-1.3	-0.9	-0.8	-1.3	-1.6	-1.6	-0.9	-1.6	-1.7	-0.5	0.2	-0.7	-1.3	-0.7
Shortness of breath walking on level ground	1.2	1.4	3.0	-0.7	-1.3	-1.0	-1.3	-1.3	-1.3	-1.3	-1.2	-1.2	-1.3	-1.2	-1.2	-0.6	-1.2	-0.2	-1.1	-1.4	-1.2	-1.7
Medication: Seretide 50 evohaler	1.2	1.3	4.7	-0.4	-1.9	-2.2	-0.6	-1.1	-0.7	0.2	-1.7	-1.9	-1.1	-1.2	-1.2	-1.4	-1.0	0.7	-0.9	-0.3	-0.5	-0.0
Chest pain or discomfort	1.2	1.7	8.9	-1.6	-1.5	-2.4	-0.8	-0.6	-0.7	-0.8	-1.1	-1.3	-0.9	-0.6	-1.1	-1.1	-0.6	1.3	-3.0	-1.3	-0.4	-0.3
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.3	0.4	0.4	1.2	1.1	1.7	1.3	-0.1	0.8	1.8	1.5	1.8	1.5	0.4	1.6	1.0	0.4	1.4	1.4	1.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	4.4	-2.1	-1.7	-2.1	-1.0	-1.0	-0.9	-1.4	-1.4	-0.9	-1.1	-0.9	-1.1	-1.3	-0.7	0.5	-1.0	-0.6	-0.8	-1.1
Alcohol drinker status: Previous	1.2	1.4	4.5	0.4	-0.4	-0.7	-1.3	-1.7	-1.3	-0.4	0.2	-1.2	-1.6	-1.6	-1.3	-0.2	-1.3	-2.1	0.8	-0.3	-1.5	-1.4
Sensitivity / hurt feelings	1.1	1.9	8.2	0.4	0.3	0.3	1.5	1.6	1.5	0.2	0.0	1.1	1.5	1.2	1.4	0.1	2.0	1.0	1.5	2.9	1.4	1.9
Average weekly fortified wine intake	1.1	1.3	3.3	-0.5	-0.9	-0.7	-1.8	-1.2	-1.4	0.0	-0.4	-1.4	-1.1	-1.4	-1.7	-0.0	-1.3	-0.5	-1.0	-1.2	-1.6	-0.7
Worrier / anxious feelings	1.1	2.1	7.4	-2.7	-1.7	0.3	-0.5	-0.1	-0.5	-1.1	-2.2	-0.7	-0.3	-0.3	-0.6	-2.1	0.3	2.6	-0.7	2.4	-0.5	1.7
Breastfed as a baby	1.1	1.3	8.9	3.0	0.7	0.2	0.7	0.2	0.6	1.8	2.1	0.7	0.5	0.1	0.9	1.2	0.3	-1.1	1.4	-0.7	0.6	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.1	1.7	1.2	0.6	1.0	1.1	1.1	1.0	1.3	0.9	1.0	1.2	0.9	0.7	1.2	-1.4	1.8	1.7	1.1	1.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	6.7	0.6	2.3	2.1	0.4	1.2	1.0	0.6	1.9	0.9	1.3	1.2	0.7	2.6	1.3	-0.3	1.1	0.4	0.7	0.6
Guilty feelings	1.1	1.7	5.4	-0.2	-1.7	-2.3	-1.2	-1.5	-1.0	-0.4	-1.4	-2.3	-1.4	-1.6	-1.2	-1.0	-1.1	-0.8	-0.1	-0.1	-1.1	-1.1
Risk taking	1.1	1.5	3.7	0.5	-0.9	-1.9	-1.6	-1.5	-1.4	-0.0	-0.5	-1.7	-1.4	-1.3	-1.3	-1.0	-1.3	-1.4	-0.5	-1.1	-1.4	-1.2
Bipolar Disorder (2018)	1.0	1.5	4.3	-0.3	0.8	-0.1	1.1	1.2	1.4	0.3	1.2	1.9	1.2	1.1	1.8	0.4	1.3	1.5	-0.6	1.2	1.6	2.1
Age at First Birth	1.0	1.5	3.7	0.8	1.3	1.2	1.2	1.3	1.4	0.4	1.5	1.3	1.3	0.9	1.4	1.7	1.1	-1.0	1.9	0.5	1.3	0.5
Neuroticism (2016)	1.0	1.4	6.2	-1.6	-1.0	-0.1	1.2	0.5	0.7	-1.1	-1.4	0.1	0.2	0.3	1.0	-1.3	0.9	2.5	-0.1	2.4	0.8	1.3
Smoking Status	1.0	2.5	5.3	1.4	2.1	1.2	1.5	1.9	1.5	1.3	2.3	2.0	1.8	2.1	1.6	1.6	1.6	-0.7	0.6	0.7	1.4	1.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.4	0.6	-0.5	-1.1	-1.2	-1.1	-1.3	-0.1	-0.2	-1.3	-1.0	-1.5	-1.3	-0.2	-1.5	-1.5	0.4	-1.6	-1.3	-1.2
Pulse rate	1.0	1.7	8.1	2.5	0.5	-1.2	-1.0	-1.4	-0.7	0.5	0.3	-0.5	-1.2	-1.8	-0.3	0.4	-1.4	-2.8	1.1	-0.7	-0.9	-1.5
Prospective memory result	1.0	1.2	3.0	0.8	1.0	1.7	1.3	1.0	1.0	0.7	1.2	1.5	1.1	1.1	1.5	0.8	1.2	-0.2	0.8	0.8	1.0	0.9
Supplements: Vitamin C	1.0	1.2	2.5	0.2	0.6	-1.1	1.4	1.2	1.4	0.8	0.5	0.7	1.1	1.2	1.5	0.3	1.2	0.5	0.7	1.6	1.6	1.4
Leg fat-free mass (right)	1.0	5.2	8.2	-2.9	-2.8	-2.5	-2.2	-2.4	-2.1	-1.4	-2.8	-2.3	-2.5	-2.4	-2.4	-2.3	-2.3	0.5	-2.5	-2.1	-1.9	-1.9
Back pain experienced in last month	1.0	1.5	9.0	-3.0	-1.7	-2.6	-0.1	0.2	-0.1	-0.9	-0.9	-0.3	0.1	0.3	-0.4	-1.5	0.2	1.9	-1.2	-0.3	0.2	0.2
Prostate Cancer	0.9	1.3	5.2	-0.9	-0.6	-1.1	1.0	1.1	0.8	1.1	0.5	0.2	1.1	0.8	0.7	-0.8	1.0	2.0	-1.4	0.6	1.0	2.3
Sitting height	0.9	6.6	13.7	-3.7	-3.2	-2.1	-2.7	-2.7	-2.8	-2.0	-2.7	-2.7	-2.7	-2.8	-2.8	-2.4	-2.6	0.7	-2.5	-2.2	-2.6	-1.9
Leg predicted mass (left)	0.9	4.9	6.2	-2.4	-2.4	-2.4	-2.3	-2.5	-2.2	-1.3	-2.2	-2.4	-2.5	-2.4	-2.4	-1.9	-2.5	-0.1	-2.4	-2.4	-2.0	-2.1
Past tobacco smoking	0.9	1.6	9.2	0.3	0.8	1.9	1.6	0.7	1.3	0.8	-0.0	0.3	0.7	0.5	0.9	0.4	1.1	1.0	1.0	3.0	1.2	2.2
Length of working week for main job	0.9	1.0	2.9	-0.1	-0.2	-0.5	-1.0	-1.1	-1.2	-0.4	-0.4	-0.7	-1.1	-1.0	-1.3	-0.5	-1.2	-0.6	-1.0	-1.7	-1.1	-1.7
Birth weight of first child	0.9	1.7	3.5	-0.2	1.6	1.0	1.4	1.4	1.6	1.3	1.3	1.6	1.3	1.4	1.9	1.2	1.3	-0.3	0.7	0.9	1.7	1.2
Medication: Omeprazole	0.9	1.0	2.7	-0.8	-1.5	-1.6	-1.0	-1.0	-1.0	-0.7	-1.1	-1.2	-1.1	-1.0	-1.2	-1.1	-0.8	-0.3	-0.4	-0.5	-0.9	-1.1
Pulse rate, automated reading	0.9	2.8	26.4	5.1	1.1	-0.9	-0.9	-1.2	-0.4	1.2	0.6	-0.2	-0.9	-1.4	-0.3	0.9	-1.1	-3.5	1.3	-0.3	-0.6	-1.1
Osteoarthritis (self-reported)	0.9	1.2	2.6	0.9	1.0	0.6	0.4	1.1	0.9	1.6	1.4	1.4	1.2	1.6	1.1	0.9	1.1	-0.5	1.2	0.9	0.9	1.0
Leg predicted mass (right)	0.9	4.8	7.8	-2.8	-2.7	-2.5	-2.1	-2.3	-2.0	-1.3	-2.7	-2.2	-2.4	-2.3	-2.3	-2.2	-2.3	0.5	-2.4	-2.0	-1.8	-1.8
Ever smoked	0.9	1.5	8.3	-0.7	-0.7	-1.2	-1.3	-0.9	-1.2	-0.9	-0.3	-0.8	-0.9	-0.6	-1.2	-0.3	-1.3	-0.4	-1.5	-2.9	-1.0	-2.2
Bipolar Disorder or Schizophrenia	0.8	2.1	4.8	-0.3	0.9	-0.7	1.8	1.5	1.8	0.7	0.9	2.0	1.4	1.5	2.2	0.9	1.4	1.2	-0.1	1.5	1.9	2.2
Neuroticism (Nagel 2018)	0.8	1.9	9.9	1.5	-0.2	-0.6	1.5	1.2	1.4	1.6	-0.1	0.3	1.2	1.1	1.1	0.3	1.8	-0.5	1.9	3.1	1.3	1.7
Coronary Artery Disease (CAD)	0.8	1.0	3.7	-1.9	-0.4	0.4	-0.9	-0.9	-0.8	-1.6	-1.5	-0.2	-1.0	-1.2	-0.1	-1.1	-1.0	1.2	-0.7	0.2	-0.8	-0.1
HbA1C	0.8	0.9	5.2	1.1	0.4	-0.6	-0.6	-0.3	-0.5	-0.1	0.3	-0.1	-0.4	-0.6	-0.5	1.0	-0.5	-2.3	0.6	-1.6	-0.6	-1.9
Diabetes (father)	0.8	1.0	3.8	1.9	1.6	-0.4	1.1	0.5	1.1	1.1	1.7	0.7	0.4	0.2	1.1	1.1	0.7	-1.0	0.6	0.5	1.1	-0.2
Leg fat-free mass (left)	0.8	4.4	5.5	-2.4	-2.3	-2.3	-2.2	-2.3	-2.1	-1.1	-2.2	-2.2	-2.3	-2.3	-2.3	-1.9	-2.3	-0.0	-2.3	-2.3	-1.9	-1.9
Age when periods started (menarche)	0.8	2.0	6.8	1.0	1.8	-0.3	0.7	0.8	1.1	1.7	2.6	1.1	1.0	0.9	0.8	2.4	0.7	-2.5	1.3	-0.9	1.0	-0.9
Qualifications: CSEs or equivalent	0.8	1.0	3.3	-1.5	-1.6	-1.8	-0.2	-0.3	-0.3	-1.3	-1.6	-0.5	-0.3	-0.5	-0.4	-1.4	-0.3	1.4	-1.0	-0.5	-0.2	-0.1
Number of self-reported non-cancer illnesses	0.8	1.4	5.7	0.0	-1.3	-2.4	-1.3	-0.6	-0.9	-0.4	-1.4	-1.1	-0.7	-0.4	-1.2	-0.8	-0.9	0.1	-1.5	-2.1	-0.6	-1.5
Eye problems/disorders: Glaucoma	0.8	1.0	4.0	-0.6	-1.0	1.0	1.0	0.6	0.4	-0.4	-0.1	0.1	0.4	0.3	0.6	-1.3	1.0	2.0	-0.4	1.9	0.4	1.7
Worry (Nagel 2018)	0.7	1.4	9.1	0.1	-0.5	0.0	1.0	1.0	0.9	0.6	-0.6	0.5	1.0	1.0	0.6	-0.8	1.6	1.2	0.7	3.0	1.0	2.1
Major Depression (MDD)	0.7	0.8	1.8	-0.6	-0.7	-0.8	-1.3	-1.4	-1.0	-0.8	-0.7	-1.3	-1.2	0.0	-1.0	-0.9	-1.0	0.6	-1.1	-0.2	-1.1	-0.4
LDL Cholesterol	0.7	1.1	3.7	-1.0	-1.0	-1.9	-0.7	-0.8	-0.6	-0.9	-1.3	-1.2	-0.9	-0.6	-0.8	-0.3	-1.2	0.5	-1.3	-1.6	-0.4	-1.4
Systolic Blood Pressure	0.7	3.6	11.5	3.4	1.8	2.1	1.6	1.8	1.6	2.0	1.8	1.8	1.8	1.3	1.6	1.8	1.9	-0.9	2.6	2.0	1.4	1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	3.7	-1.9	-0.3	-0.1	-0.3	0.3	-0.3	-1.3	-0.4	0.4	0.2	0.4	0.0	-0.3	0.1	1.6	-1.8	-1.5	-0.2	-0.9
Medication: Co-codamol	0.7	0.9	2.5	-0.8	-1.0	-1.6	-0.9	-0.8	-0.7	-0.7	-0.1	-0.8	-0.8	-1.1	-1.0	-0.7	-0.8	-0.4	-0.9	-1.3	-0.6	-1.5
Severe depression (siblings)	0.7	0.8	3.3	0.5	0.7	0.2	0.8	0.6	0.7	1.4	1.5	1.0	0.9	0.4	0.6	0.5	0.8	-1.1	1.8	1.0	0.6	0.7
Impedance of leg (right)	0.7	3.2	9.0	1.9	2.8	2.3	1.2	1.6	1.3	1.3	3.0	1.9	1.8	1.6	1.2	2.6	1.5	-1.2	1.8	0.8	1.1	0.9
High blood pressure	0.7	1.9	5.0	0.8	0.5	0.0	1.3	2.0	1.5	1.4	0.6	1.3	1.9	2.2	1.3	0.5	2.1	-0.0	1.2	1.5	1.6	1.2
Allergy	0.7	1.7	4.2	1.8	1.8	0.8	0.8	0.8	0.8	1.8	1.9	1.5	1.0	0.5	1.1	1.3	0.8	-1.7	2.0	1.1	0.7	0.9
Standing height	0.7	6.7	12.6	-2.9	-2.5	-1.3	-3.1	-3.1	-3.0	-0.9	-2.0	-2.5	-3.0	-3.1	-3.5	-1.8	-3.1	-0.4	-2.5	-2.8	-3.0	-2.1
Comparative body size at age 10	0.7	1.9	4.2	0.9	2.0	1.3	1.4	1.6	1.5	0.1	1.2	2.0	1.5	2.0	1.8	1.6	1.6	-0.2	0.3	0.1	1.5	-0.1
Eye problems/disorders: None of the above	0.7	0.8	2.1	-0.8	-0.6	-0.5	-1.1	-0.8	-0.8	-0.6	-1.2	-0.6	-0.9	-0.5	-1.1	-0.3	-1.1	0.5	-1.5	-1.4	-0.8	-1.0
Heart disease (mother)	0.7	0.9	1.6	0.4	0.7	0.5	1.1	1.2	1.1	1.0	-0.1	0.9	1.0	1.3	1.0	0.4	1.3	0.8	0.2	1.2	1.2	1.2
Arm predicted mass (right)	0.7	3.4	6.0	-2.0	-2.0	-2.2	-1.7	-1.9	-1.6	-1.2	-1.7	-2.1	-2.0	-1.6	-1.9	-1.4	-1.9	-0.3	-2.0	-2.4	-1.4	-2.3
Suffer from ‘nerves’	0.7	1.1	4.0	-1.1	-0.4	0.3	0.9	1.2	0.9	-0.6	0.2	0.6	1.0	1.1	0.5	-0.4	1.6	2.0	-0.6	1.5	1.0	1.3
Knee pain experienced in last month	0.7	1.1	5.0	-1.2	-1.0	-0.9	-1.1	-0.8	-0.8	-0.6	-0.9	-1.0	-0.8	-1.0	-1.0	-0.4	-1.3	-0.0	-1.5	-2.2	-0.6	-1.2
Unable to work because of sickness or disability	0.7	0.9	6.0	0.3	1.3	0.6	0.5	-0.2	0.1	0.4	0.8	0.2	-0.1	0.4	0.0	1.8	-0.4	-2.4	1.1	-1.2	-0.1	-1.4
Vascular/heart problems diagnosed by doctor	0.7	1.8	4.8	-0.8	-0.9	-0.4	-1.1	-2.0	-1.4	-1.3	-0.7	-1.3	-1.8	-2.2	-1.1	-0.7	-2.0	0.3	-1.6	-1.4	-1.4	-0.9
Depression (Nagel 2018)	0.6	0.9	2.3	0.6	0.7	0.7	1.4	1.0	1.1	0.6	0.3	0.8	0.9	1.1	1.1	0.6	1.3	-0.5	1.3	1.5	1.0	0.5
Blood Eosinophil Count	0.6	4.9	18.0	-2.7	-4.0	-2.8	-0.4	-0.1	-0.7	-1.7	-2.8	-1.1	-0.3	0.0	-0.8	-3.7	-0.3	4.2	-3.4	0.3	-0.3	2.2
Allergy or Eczema	0.6	1.5	6.6	-0.1	0.9	2.6	1.7	1.1	1.5	-0.4	-0.0	0.9	0.9	1.3	1.4	0.8	1.2	1.3	0.6	1.6	1.4	1.1
Tanning	0.6	7.0	18.1	-1.0	-2.0	-4.3	-3.1	-2.9	-3.1	-0.4	-1.7	-3.1	-2.7	-2.7	-3.3	-1.1	-3.2	-1.5	-1.6	-3.0	-3.1	-3.1
Chronic bronchitis/emphysema (father)	0.6	0.7	4.3	1.3	0.7	0.3	-0.8	-1.0	-0.5	0.3	0.1	-0.2	-1.0	-0.8	-0.3	0.4	-0.9	-2.1	0.5	-0.3	-0.6	-1.1
Had other major operations	0.6	0.7	2.1	-1.2	-1.1	0.2	-0.4	-0.5	0.1	0.3	-1.0	-1.5	-0.5	-0.3	-0.5	-1.1	-0.6	1.2	-0.5	1.2	0.1	1.3
Financial difficulties in last 2 years	0.6	0.7	2.1	-1.0	-0.2	0.9	-0.7	-1.1	-0.7	-1.4	-0.8	-0.9	-1.2	-0.8	-0.5	-0.5	-1.1	0.1	-0.7	-0.4	-0.8	-1.2
Heart attack	0.6	0.8	2.8	0.8	1.2	1.1	0.3	0.8	0.5	0.1	0.9	1.1	0.7	0.9	1.1	1.3	0.7	-1.1	1.7	0.4	0.3	0.2
Fluid intelligence score	0.6	1.3	3.8	0.8	1.2	0.8	0.8	1.4	0.9	1.5	2.0	0.8	1.4	1.5	0.5	1.1	1.3	-0.7	0.9	0.4	0.8	1.1
Depression (self-reported)	0.6	0.8	2.0	-0.1	-1.1	-1.2	-0.9	-0.7	-0.7	-0.5	-1.1	-0.9	-0.7	-1.0	-0.8	-0.3	-0.9	-0.7	0.0	-1.4	-0.6	-1.3
Exposure to tobacco smoke at home	0.6	0.7	1.9	0.7	0.8	-0.7	0.5	0.8	0.8	0.3	1.0	0.4	0.7	1.2	0.8	1.4	0.7	-1.2	0.8	-0.7	0.8	-0.6
Medication: Amlodipine	0.6	0.9	1.7	0.6	-1.0	-1.2	-1.2	-0.9	-1.0	-0.4	-1.0	-1.0	-0.9	-0.8	-1.2	-0.8	-1.0	-0.3	-0.6	-0.9	-1.0	-1.3
Arm fat-free mass (right)	0.6	3.2	6.0	-2.0	-2.0	-2.3	-1.7	-1.8	-1.5	-0.9	-1.5	-2.1	-1.9	-1.6	-1.9	-1.2	-1.8	-0.4	-1.9	-2.5	-1.3	-2.1
Exposure to tobacco smoke outside home	0.6	0.8	1.8	0.8	-0.5	-0.7	-0.9	-1.1	-0.9	-1.2	-0.8	-1.0	-1.3	-1.3	-0.5	-0.4	-1.0	-0.6	-0.2	-0.4	-0.9	-1.3
Health satisfaction	0.6	0.8	3.5	-1.9	-1.2	-1.0	-1.0	-0.7	-0.7	-0.9	-0.8	-0.5	-0.9	-0.9	-0.6	-1.0	-0.6	0.5	-1.0	0.5	-0.7	0.1
Medication for pain relief, constipation, heartburn	0.6	0.9	5.2	1.7	1.7	2.3	0.6	0.1	0.5	0.0	0.8	0.3	0.1	0.1	0.6	0.9	0.3	-0.1	0.4	1.8	0.3	1.0
Hypertension (Self-reported)	0.6	1.8	4.5	1.5	0.5	-0.0	1.1	1.9	1.3	1.6	0.6	1.2	1.8	2.1	1.0	0.7	2.0	-0.7	1.5	1.2	1.4	0.8
Whole body fat-free mass	0.6	3.5	5.3	-2.2	-2.0	-2.1	-1.8	-2.1	-1.7	-1.0	-1.9	-1.9	-2.1	-2.0	-2.0	-1.5	-2.0	-0.2	-2.1	-2.3	-1.5	-2.0
Whole body water mass	0.6	3.5	5.2	-2.2	-2.1	-2.1	-1.8	-2.1	-1.7	-1.0	-1.8	-2.0	-2.1	-1.9	-2.0	-1.5	-2.0	-0.2	-2.1	-2.3	-1.5	-2.0
Illnesses of father: High blood pressure	0.6	0.8	1.7	1.3	1.2	0.6	0.8	0.7	1.0	1.1	0.8	0.8	0.8	0.7	1.0	0.9	0.6	-0.5	0.5	0.9	0.9	0.9
Basal cell carcinoma (self-reported)	0.6	0.7	1.5	0.2	0.7	0.2	1.0	1.1	1.0	1.2	0.2	0.9	1.0	0.8	1.0	0.8	0.9	-0.2	0.8	0.7	1.0	1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.1	0.7	1.1	1.1	0.3	0.8	0.5	0.1	0.8	1.2	0.8	1.0	1.1	1.1	0.7	-0.8	1.5	0.4	0.3	0.3
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.8	1.5	0.6	0.7	0.4	1.1	0.4	1.4	1.7	0.6	1.3	1.1	0.3	1.1	1.0	-1.7	1.9	0.2	0.3	0.4
Blood Platelet Count	0.5	6.2	14.8	-0.0	-2.1	-3.9	-2.6	-2.5	-2.7	-2.6	-1.9	-1.9	-2.3	-3.1	-2.1	-1.7	-2.5	-1.1	-1.3	-3.6	-2.6	-3.6
Height	0.5	8.9	21.9	-4.7	-3.9	-2.7	-3.6	-3.0	-3.3	-0.7	-2.0	-2.7	-3.0	-3.1	-3.8	-3.0	-2.9	0.3	-3.4	-2.7	-3.1	-1.1
Average weekly spirits intake	0.5	0.6	2.4	0.4	-0.5	-0.4	0.7	0.5	0.8	1.4	-0.9	-0.3	0.4	0.9	0.5	-0.4	0.3	0.5	0.0	1.0	0.9	1.5
Impedance of leg (left)	0.5	2.6	5.5	1.3	2.2	2.0	1.3	1.6	1.4	1.1	2.3	1.7	1.8	1.7	1.1	2.4	1.7	-0.6	1.6	1.1	1.1	1.1
Alcohol usually taken with meals	0.5	0.8	5.2	1.1	0.3	-0.3	-0.8	-0.5	-0.7	0.5	1.5	-0.1	-0.3	-0.1	-0.8	0.7	-0.4	-2.3	1.3	-0.8	-0.8	-1.0
Nervous feelings	0.5	1.0	3.7	-1.0	-1.3	0.1	0.2	-0.2	-0.2	-1.4	-1.9	-0.8	-0.3	-0.5	-0.3	-1.5	0.2	1.9	-0.7	1.6	-0.1	1.1
Father’s age at death	0.5	0.7	3.3	0.1	-0.3	1.8	-0.1	-0.6	-0.3	-0.8	0.3	-1.1	-0.7	-0.5	-0.3	-1.5	-0.4	0.7	-0.6	1.2	-0.4	1.0
Illnesses of mother	0.5	0.7	2.0	0.8	0.3	0.1	1.1	1.0	1.1	0.5	0.0	1.1	0.9	1.2	1.4	0.4	0.8	0.1	0.4	0.1	1.3	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.7	3.4	-0.3	-0.2	-0.5	-0.5	-0.8	-0.6	-0.9	-1.2	-0.8	-0.9	-0.3	-0.9	0.1	-0.7	-0.4	-0.5	-1.2	-0.6	-1.8
Number of children fathered	0.5	0.5	3.5	-1.7	-0.3	-0.8	-0.0	0.0	0.2	-0.6	0.4	0.1	0.0	0.2	0.6	-0.7	0.1	1.9	-1.2	-0.2	0.4	-0.0
Had major operations	0.5	0.6	2.1	0.8	0.4	-1.4	0.7	0.7	0.8	0.7	0.6	1.1	0.7	0.6	1.1	0.2	0.6	-0.3	0.6	0.2	0.9	0.5
Age at last live birth	0.5	0.7	2.2	-0.3	0.5	1.2	0.5	0.7	0.9	0.2	0.6	0.6	0.8	0.9	0.8	0.5	0.9	1.1	0.8	1.5	0.8	1.5
Eye problems/disorders: Cataract	0.5	0.6	1.7	0.7	0.2	0.1	-0.9	-0.9	-0.8	-0.4	0.1	-0.4	-0.8	-1.3	-0.7	0.0	-1.1	-1.0	0.2	-1.0	-0.8	-1.0
Medication: Gliclazide	0.5	0.6	3.4	1.9	0.2	0.2	-0.2	0.2	-0.1	1.1	-0.4	0.0	0.2	0.3	-0.6	0.3	0.2	-1.7	1.4	0.0	-0.2	-0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	2.3	-0.6	-1.4	-0.8	0.8	0.7	0.4	-0.3	-0.6	0.5	0.7	1.0	0.2	-0.9	0.6	1.5	-0.5	-0.1	0.5	0.3
Average weekly champagne plus white wine intake	0.5	0.7	3.4	-0.1	0.1	1.1	-0.6	-0.5	-0.7	-0.8	0.9	-0.4	-0.5	-0.1	-0.9	0.3	-0.8	-0.9	-0.5	-1.9	-0.7	-1.5
Mother’s age at death	0.5	0.6	1.7	1.1	-0.6	-1.3	-0.5	-0.3	-0.8	1.2	0.1	-0.9	-0.1	-0.7	-0.8	-0.1	-0.4	-1.2	0.5	-0.9	-0.8	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.2	-1.5	-0.5	0.7	-0.4	-0.3	-0.3	-1.3	-0.7	0.1	-0.2	-0.3	-0.2	-0.9	-0.4	1.0	-1.5	-0.9	-0.3	-0.3
Alcohol drinker status: Never	0.5	0.6	2.4	0.6	0.3	0.4	0.8	0.7	0.7	0.1	-0.7	0.5	0.6	0.6	0.6	-0.3	0.8	1.3	-0.1	1.5	0.8	1.5
Basal metabolic rate	0.5	3.0	4.8	-2.2	-1.8	-2.1	-1.7	-1.9	-1.5	-1.0	-1.6	-1.8	-1.9	-1.8	-1.8	-1.3	-1.8	-0.2	-2.0	-2.2	-1.4	-1.9
Arm fat-free mass (left)	0.5	2.4	5.5	-1.9	-1.7	-2.2	-1.3	-1.6	-1.3	-0.7	-1.2	-1.8	-1.6	-1.3	-1.6	-1.0	-1.6	-0.5	-1.7	-2.4	-1.1	-2.0
Age started oral contraceptive pill	0.5	0.7	3.0	-0.6	-0.9	-1.1	-0.8	-0.8	-0.5	-0.5	-1.1	-1.0	-0.9	-0.6	-0.7	-0.6	-0.9	0.8	-1.7	-0.2	-0.5	0.2
Supplements: Calcium	0.5	0.6	1.8	0.7	-0.4	-0.2	-0.9	-1.1	-0.7	-0.6	-0.7	-0.6	-1.2	-1.3	-0.3	-0.8	-1.2	0.5	-0.7	-0.1	-0.7	-0.1
Schizophrenia (2018)	0.4	0.8	2.0	-0.2	0.4	-0.8	1.4	0.9	1.2	0.7	0.2	1.1	0.8	1.0	1.4	0.8	0.8	0.4	0.3	1.0	1.2	1.1
Ovarian Cancer	0.4	0.5	1.5	0.5	-0.2	-1.2	-0.4	-1.0	-0.2	0.7	-1.2	-0.9	-0.8	-1.2	-0.4	0.1	-1.0	-0.8	0.4	-0.1	-0.3	-0.2
Primary Biliary Cirrhosis	0.4	0.5	3.2	-1.8	-0.5	-0.5	0.7	0.2	0.8	0.3	-0.3	0.3	0.2	-0.0	0.7	-0.2	0.2	0.8	0.5	1.1	0.8	1.0
Rheumatoid Arthritis	0.4	0.6	1.5	-1.1	1.0	1.0	1.0	0.6	0.9	0.5	1.2	0.2	0.5	0.7	0.1	0.6	0.6	-0.6	0.5	0.8	0.9	0.7
Schizophrenia (2014)	0.4	0.9	2.5	-0.6	0.3	-0.2	1.4	0.9	1.1	0.0	-0.3	1.1	0.7	0.9	1.6	0.3	0.8	1.1	-0.1	1.3	1.1	1.2
Cardiovascular Disease	0.4	1.2	3.1	1.6	0.2	-1.3	0.5	1.6	0.9	1.2	0.4	1.2	1.4	1.8	0.8	0.3	1.7	-0.8	1.1	0.6	1.1	0.2
Neuroticism	0.4	1.0	6.2	1.4	-0.5	-0.8	0.7	0.8	0.9	0.8	-0.6	0.4	0.7	0.9	0.8	-0.0	1.2	-0.0	1.4	2.5	0.8	1.3
Hand grip strength (left)	0.4	1.0	3.0	0.3	-0.7	0.7	-1.4	-0.9	-1.4	0.1	-0.1	-0.7	-0.8	-1.3	-1.7	-1.4	-1.0	-0.4	-0.9	-1.0	-1.4	-0.6
Relative age of first facial hair	0.4	0.9	2.1	1.3	1.4	0.7	0.9	0.8	1.0	0.6	1.4	1.0	0.7	0.8	1.1	1.4	0.9	-0.7	0.7	0.5	1.0	0.1
Fed-up feelings	0.4	0.7	2.7	-0.7	-0.1	0.1	1.4	0.9	1.1	-0.4	-0.3	0.8	0.7	1.0	1.1	0.3	1.2	0.5	0.7	1.6	1.1	0.5
Relative age voice broke	0.4	0.7	1.7	0.6	1.1	0.8	1.2	0.8	0.8	0.6	1.3	0.8	0.8	0.9	1.0	0.9	0.8	0.2	0.4	0.4	0.9	0.3
Waist circumference	0.4	1.4	4.0	-0.6	-0.9	-1.9	-1.6	-1.0	-0.9	-1.3	-0.4	-1.1	-1.1	-0.8	-1.2	-0.1	-1.1	-0.4	-1.2	-2.0	-0.9	-1.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	-1.0	-1.2	-0.1	-0.2	0.0	-0.4	-0.4	-0.6	-0.1	-0.0	-0.3	-0.5	-1.2	0.1	1.2	-1.2	-0.9	-0.3	-0.3
Medication: Ramipril	0.4	0.5	1.5	0.8	0.0	0.2	0.0	0.7	0.1	0.9	0.6	1.1	0.7	1.2	0.2	-0.3	0.8	-0.2	1.0	0.8	0.1	0.8
Neuroticism score	0.4	0.8	3.4	-0.6	-1.6	-0.7	0.2	0.0	-0.0	-0.8	-1.7	-0.6	-0.2	-0.2	-0.0	-1.2	0.4	1.2	0.0	1.8	0.0	0.7
Weight	0.4	1.9	5.3	-1.6	-1.4	-2.3	-1.6	-1.4	-1.1	-0.7	-0.8	-1.5	-1.3	-1.1	-1.5	-0.5	-1.3	-0.6	-1.4	-2.0	-1.1	-1.7
Trunk fat-free mass	0.4	2.3	4.5	-1.7	-1.5	-1.6	-1.4	-1.7	-1.3	-0.7	-1.3	-1.6	-1.7	-1.6	-1.6	-1.0	-1.7	-0.4	-1.7	-2.1	-1.1	-1.9
Time employed in main current job	0.4	0.5	3.8	-1.2	-0.9	-2.0	-0.5	-0.2	-0.4	0.6	-0.3	-0.1	-0.1	-0.6	-0.8	-0.6	-0.4	0.3	-0.6	-0.9	-0.3	0.1
Happiness	0.4	0.5	2.2	-0.9	-0.6	-0.5	-0.4	-0.8	-0.3	-0.6	-0.7	-0.4	-0.9	-0.8	0.0	-1.0	-0.4	0.3	0.1	1.5	-0.4	0.4
Pulse wave Arterial Stiffness index	0.4	0.5	4.9	0.4	-0.7	-2.2	-0.5	-0.0	-0.2	1.1	0.0	-0.8	0.2	-0.2	-0.4	-0.4	-0.1	-0.1	-0.9	-0.7	-0.1	0.3
Trunk predicted mass	0.4	2.5	4.5	-1.8	-1.6	-1.6	-1.5	-1.8	-1.4	-0.7	-1.4	-1.7	-1.8	-1.7	-1.7	-1.1	-1.8	-0.5	-1.8	-2.1	-1.2	-1.9
Tense / ‘highly strung’	0.4	0.7	1.7	0.7	-0.0	-0.6	1.2	1.0	1.2	0.8	-0.1	0.2	0.8	0.8	0.8	0.2	1.2	0.2	0.7	1.3	1.3	0.8
Pulse wave reflection index	0.4	0.5	1.6	-1.2	-0.7	-1.2	-0.5	0.1	-0.2	0.0	-1.1	-0.6	0.1	0.4	-0.4	-1.0	0.1	1.2	-1.1	0.1	-0.2	0.5
Birth weight	0.4	1.0	2.8	0.4	-0.2	0.5	-1.5	-1.0	-1.2	0.1	-0.1	-0.5	-0.8	-1.4	-0.9	0.0	-1.4	-1.7	-0.5	-1.5	-1.4	-0.4
Number of full brothers	0.4	0.6	2.9	0.9	-0.5	-1.7	0.6	0.7	0.4	1.0	0.9	0.6	0.8	1.0	0.4	0.4	0.8	-0.5	0.3	-0.6	0.5	-0.1
Worry too long after embarrassment	0.4	0.7	1.8	0.9	-1.4	-0.9	-0.7	-0.7	-0.9	-0.1	-1.0	-1.2	-0.5	-1.2	-1.2	-0.7	-0.4	-0.3	0.3	-0.0	-1.0	-0.5
Pulse wave peak to peak time	0.4	0.4	4.1	-0.8	0.4	2.0	0.2	-0.3	-0.1	-1.4	-0.3	0.6	-0.5	-0.0	0.1	0.2	-0.2	0.2	0.5	0.3	-0.2	-0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	1.2	1.1	1.1	-0.3	0.1	0.1	0.2	1.0	0.7	0.2	0.3	0.8	1.2	-0.1	-1.1	0.8	-0.4	-0.0	-0.1
Neck or shoulder pain in last month	0.4	0.5	1.6	-1.0	-0.2	0.4	0.6	1.0	0.7	-0.4	0.5	0.2	0.8	1.0	0.7	-0.3	1.1	1.3	0.2	0.5	0.9	0.6
Number of full sisters	0.4	0.5	1.3	1.1	0.6	-0.2	1.1	0.6	0.9	0.6	1.0	0.1	0.7	0.4	1.1	0.1	0.5	0.5	-0.4	-0.2	1.1	0.7
Leg pain on walking	0.4	0.5	1.8	-1.3	-0.6	-1.2	0.1	0.9	0.2	-0.1	0.6	0.4	0.9	0.7	0.1	0.4	0.5	0.4	-1.0	-1.4	0.4	-0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	-0.7	0.2	0.6	1.0	0.6	0.8	-0.0	0.6	0.5	0.6	0.7	1.0	-0.1	0.8	0.4	0.4	0.8	0.8	0.5
Illnesses of father: Heart disease	0.4	0.5	2.1	-1.1	1.1	1.4	0.2	0.6	0.4	-0.2	0.8	0.3	0.4	0.5	0.6	0.7	0.6	1.0	-0.5	0.6	0.5	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	-0.6	0.4	0.7	0.7	0.8	0.7	0.1	0.6	1.2	0.7	0.4	0.8	-0.1	1.1	0.5	0.5	0.9	0.7	0.6
Loneliness, isolation	0.4	0.5	3.1	0.4	-0.8	-1.7	0.5	0.1	0.1	-0.1	-1.2	-0.5	-0.3	0.0	-0.0	-0.0	0.2	-0.5	0.1	-0.7	0.3	-1.8
Long-standing illness, disability or infirmity	0.4	0.7	2.9	0.6	0.6	-0.4	-1.3	-0.7	-0.6	-0.2	0.1	-0.9	-0.7	-0.7	-0.6	1.1	-1.0	-1.7	0.4	-0.9	-0.7	-0.7
Breast cancer (self-reported)	0.4	0.4	1.4	-1.2	0.4	-0.8	0.8	0.5	1.0	0.2	0.3	0.3	0.6	0.5	1.0	0.6	0.4	0.7	-0.4	-0.1	1.1	0.4
Hearing aid user	0.4	0.5	2.1	0.8	1.0	1.3	-0.4	0.2	0.2	0.9	0.7	0.5	0.4	0.2	0.6	1.0	0.2	-1.4	0.9	0.1	0.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	3.0	-1.7	-0.7	-1.0	-0.6	-0.4	-0.5	-0.5	-0.7	-0.4	-0.4	-0.4	-0.7	-0.6	-0.6	-0.2	-0.5	-0.7	-0.4	-0.5
Arm predicted mass (left)	0.4	1.9	4.9	-1.5	-1.3	-1.7	-1.1	-1.5	-1.0	-0.7	-0.9	-1.6	-1.5	-1.2	-1.3	-0.6	-1.5	-0.7	-1.4	-2.2	-0.9	-2.0
Depressed Affect (Nagel 2018)	0.3	0.7	2.6	1.2	-0.1	-0.2	0.8	0.6	0.8	1.1	-0.1	-0.3	0.5	0.6	0.7	0.4	1.0	-1.0	1.2	1.6	0.7	0.6
Breast Cancer	0.3	0.7	2.7	-1.1	-1.1	-1.6	-0.2	-0.6	-0.6	-0.0	-1.5	-1.1	-0.8	-0.7	-0.7	-0.7	-0.8	-0.0	-0.3	-0.6	-0.5	-0.3
Body Mass Index (BMI) (2010)	0.3	0.5	1.2	-0.0	0.3	-0.6	0.9	0.9	1.0	0.6	0.7	0.4	1.1	0.7	0.4	0.9	0.9	0.1	0.1	-0.1	1.1	0.5
Crohns Disease (2012)	0.3	0.5	2.2	-1.2	1.3	1.5	-0.1	0.0	-0.0	-1.0	-0.6	1.0	-0.1	-0.2	0.5	-0.1	-0.2	0.9	-0.2	0.4	-0.2	0.2
Fasting Glucose	0.3	0.4	0.9	-0.7	0.2	-0.0	0.7	0.9	0.6	0.1	0.9	1.0	1.0	0.8	0.7	0.5	0.6	0.1	-0.3	-0.4	0.7	0.2
Lupus	0.3	0.5	1.5	-0.4	-1.2	0.5	-0.5	-0.2	-0.7	-1.1	-0.9	-0.3	-0.5	0.3	-0.1	-1.0	-0.0	0.9	0.7	1.1	-0.7	0.4
Triglycerides	0.3	0.6	1.6	0.2	0.6	0.8	1.3	-0.2	1.1	1.1	0.8	-0.7	0.1	-0.5	0.6	0.5	-0.1	0.5	0.4	0.4	1.2	1.2
Blood Red Count	0.3	3.2	17.8	3.7	0.9	-1.4	0.5	0.3	0.7	4.2	1.2	-1.8	1.0	0.2	-0.8	2.1	0.3	-3.5	1.3	0.2	0.4	0.9
BMI	0.3	1.5	8.6	0.2	-0.7	-2.9	-1.0	-0.4	-0.4	0.0	0.5	-0.9	-0.2	-0.1	-0.7	0.5	-0.8	-1.5	-0.6	-2.9	-0.3	-1.9
Lung FVC	0.3	1.7	10.9	-0.2	-0.7	1.0	-0.2	0.0	-0.2	-1.6	-1.9	-0.2	0.0	0.2	-0.9	-1.7	-0.1	3.3	-2.0	1.0	-0.3	2.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	-0.4	-0.9	-0.5	-0.6	-0.0	-0.7	-0.4	-0.3	-0.4	-0.1	-0.1	-0.7	-0.1	-0.2	-0.5	-0.6	-1.0	-0.7	-0.6
Angina	0.3	0.4	1.0	0.8	0.8	0.5	0.7	0.7	0.7	0.4	0.2	0.5	0.6	0.9	0.7	1.0	0.6	-0.6	1.0	0.5	0.6	-0.1
Vitamin and mineral supplements	0.3	0.4	2.6	-1.1	-0.4	0.3	-0.1	-0.6	-0.3	0.1	-0.2	-0.7	-0.4	-0.5	-0.7	-0.5	-0.2	0.8	-1.6	-0.8	-0.3	-0.5
Taking other prescription medications	0.3	0.5	2.6	1.6	-0.2	-0.7	-0.5	-0.3	-0.3	0.2	-0.2	-0.3	-0.4	-0.5	-0.4	0.3	-0.8	-1.1	-0.2	-1.2	-0.2	-0.9
Hearing difficulty/problems with background noise	0.3	0.5	1.6	-0.7	-0.4	-0.7	0.7	1.0	0.5	-0.5	-0.0	0.7	0.9	0.8	0.3	0.5	0.7	1.2	-0.3	0.0	0.6	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	3.3	0.3	-0.6	-1.8	0.6	0.5	0.6	0.7	0.3	0.2	0.6	0.1	0.4	-0.0	0.6	0.2	-0.2	-0.3	0.7	-0.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.7	1.3	0.7	0.4	0.3	0.2	0.4	0.4	0.8	-0.2	0.2	0.8	0.3	0.8	0.4	-1.1	0.4	0.4	0.3	-0.0
Medication: Simvastatin	0.3	0.5	0.9	0.6	0.5	0.3	0.3	0.8	0.5	0.8	0.8	0.6	0.8	0.9	0.5	0.3	0.8	-0.9	0.7	-0.9	0.7	-0.6
Falls in the last year	0.3	0.4	2.3	0.3	0.2	-0.1	-0.1	0.2	-0.0	0.7	0.5	-0.2	0.3	0.4	-0.2	1.0	0.1	-1.5	1.3	-0.3	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	-0.4	-0.7	-0.4	-0.8	-0.8	-0.7	-1.0	-0.8	-1.1	-0.9	-0.6	-0.7	-1.1	-0.6	-0.6	0.5	0.3	-0.7	-0.5
Loud music exposure frequency	0.3	0.3	1.7	0.1	-0.7	0.4	0.3	-0.3	-0.1	-0.2	-0.4	-0.4	-0.3	-0.3	-0.2	-0.9	0.1	0.2	0.2	1.3	-0.2	1.0
Forced vital capacity (FVC), Best measure	0.3	1.2	3.4	-0.7	-1.0	0.6	-1.3	-0.9	-1.3	-0.9	-1.6	-0.7	-0.8	-1.0	-1.8	-1.2	-1.2	0.7	-1.5	-1.0	-1.4	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.3	-0.8	-1.0	-0.3	-0.4	-0.2	-0.2	-0.9	-1.0	-0.1	-0.3	-0.0	-0.1	-1.1	0.2	0.9	-0.2	1.0	-0.2	0.5
Alcohol intake frequency.	0.3	0.8	4.1	1.9	1.5	2.0	0.1	0.1	0.5	-0.2	0.6	1.0	0.2	0.2	0.5	1.1	0.1	-1.0	0.8	0.7	0.3	0.1
Overall health rating	0.3	0.6	2.4	-0.7	-0.4	-1.1	-1.2	-0.5	-0.7	-0.5	0.0	-0.7	-0.6	-0.4	-0.9	0.3	-0.5	-1.5	-0.1	-1.2	-0.7	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	-0.3	-0.4	-0.4	-0.7	-0.8	-0.6	-0.8	-0.6	-0.7	-0.8	-0.8	-0.2	-0.4	-1.0	0.5	-0.8	-0.4	-0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.1	-0.9	-1.3	-0.4	-0.8	-0.5	-0.8	-0.0	-0.7	-0.5	-0.5	-0.5	-1.0	-1.4	-0.6	0.2	-0.8	-0.8	-0.7	-0.5
Mood swings	0.3	0.6	3.5	-0.4	-1.0	0.2	-0.1	-0.5	-0.3	-0.5	-1.6	-1.0	-0.6	-0.5	-0.4	-1.0	-0.1	0.5	0.2	1.9	-0.3	0.6
Diabetes diagnosed by doctor	0.3	0.5	1.9	1.2	0.8	0.1	-0.3	0.6	0.3	0.6	0.6	0.5	0.5	0.7	0.3	1.1	0.5	-1.4	0.6	-0.7	0.3	-0.9
Qualifications: nursing, teaching	0.3	0.4	2.0	0.2	-0.6	0.2	-0.5	-0.8	-0.6	-0.4	-0.1	-1.0	-0.6	-1.0	-0.8	-1.4	-0.6	0.0	0.3	0.5	-0.7	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.4	-1.2	0.6	0.9	0.5	0.4	0.5	-0.3	0.5	0.2	0.4	1.0	0.3	0.9	0.3	0.1	0.4	-0.5	0.5	-0.4
Medication: Bendroflumethiazide	0.3	0.4	1.8	-0.4	0.3	0.8	0.6	0.7	0.5	0.1	-0.6	0.8	0.6	0.6	0.6	-0.4	0.9	0.3	0.6	1.4	0.4	0.8
Ever depressed for a whole week	0.3	0.4	1.5	-0.4	-0.0	0.1	-0.6	-0.7	-0.7	-0.1	0.4	-1.2	-0.5	-0.1	-0.7	0.5	-0.6	-1.0	0.3	-0.3	-0.9	-0.6
Cholesterol lowering medication	0.3	0.5	2.8	-0.1	0.8	0.8	-0.6	-0.4	-0.3	-0.5	0.1	-0.5	-0.5	-0.1	-0.5	0.7	-0.4	-1.2	-0.2	-1.3	-0.3	-1.7
Heart disease (siblings)	0.3	0.3	0.9	0.5	0.1	0.2	0.5	0.6	0.5	0.1	0.5	0.2	0.6	0.9	0.3	0.0	0.7	0.8	0.6	1.0	0.4	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	-0.2	-0.6	1.0	-0.1	-0.3	-0.1	-0.7	-0.6	-0.6	-0.2	0.0	-0.3	-0.5	-0.3	-0.0	-0.3	-0.6	-0.2	-0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	2.8	-0.2	-0.1	1.7	0.3	0.1	0.2	-0.8	-1.3	-0.2	0.1	0.5	0.1	-0.0	0.0	0.6	-0.4	-0.3	0.2	0.1
Waist Hip Ratio (WHR)	0.2	0.7	3.7	0.8	0.9	0.1	-0.5	-0.2	-0.2	-0.9	0.7	0.5	-0.3	-0.3	-0.5	1.2	-0.4	-1.3	0.3	-1.7	-0.3	-1.9
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.7	0.9	0.2	-0.4	-0.1	0.2	0.2	-0.1	0.2	0.1	0.2	0.3	0.2	0.8	0.2	-1.2	0.7	-0.8	0.2	-1.3
Number of treatments/medications taken	0.2	0.4	3.4	0.5	-1.1	-1.9	-0.2	-0.1	-0.1	0.9	-0.4	-0.4	-0.1	0.1	-0.3	-0.3	-0.4	-0.8	-0.2	-1.0	0.1	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.0	-0.2	-0.3	0.7	0.7	0.6	0.2	-0.8	0.7	0.6	0.8	0.5	0.2	1.0	-0.3	0.8	0.7	0.6	-0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	-0.1	0.4	0.6	0.1	0.4	0.3	0.8	0.4	-0.4	0.4	0.6	0.0	0.7	0.4	-0.4	0.4	0.5	0.3	0.8
Diabetes (mother)	0.2	0.3	1.0	-0.1	0.2	0.0	0.4	0.7	0.7	0.8	-0.3	0.4	0.6	0.3	0.6	0.8	0.6	-0.8	1.0	0.0	0.7	0.0
Townsend deprivation index at recruitment	0.2	0.3	1.6	0.3	0.4	-0.4	-0.4	0.3	-0.3	-0.5	-0.4	-0.3	0.2	0.1	-0.8	0.6	-0.0	0.0	-0.6	-1.3	-0.3	-0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.9	0.9	0.4	0.2	0.1	0.3	0.5	0.3	-0.0	0.6	0.2	0.6	0.6	-0.0	0.2	-0.1	-0.1	0.6	0.5	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.3	0.4	0.4	1.5	-0.8	-0.5	-0.4	0.2	-0.3	-1.0	-0.5	-0.8	-0.5	0.3	-0.7	-0.9	1.2	0.6	-0.6	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	-0.1	0.1	1.1	0.9	0.7	0.8	-0.1	-0.1	0.3	0.5	0.7	0.7	0.4	0.8	0.9	0.2	0.9	0.8	0.7
Trunk fat mass	0.2	1.0	4.1	-1.2	-0.7	-2.0	-1.4	-0.8	-0.7	-0.3	0.1	-0.9	-0.7	-0.6	-1.0	0.3	-0.8	-0.9	-0.7	-1.7	-0.7	-1.2
Number of incorrect matches in round	0.2	0.3	2.3	-1.1	-0.5	-1.5	0.0	-0.2	-0.0	-0.1	0.0	0.2	-0.1	0.2	-0.3	-0.8	-0.1	-0.1	-0.6	-0.9	0.2	-0.3
Forced vital capacity (FVC)	0.2	1.0	3.3	-0.6	-0.8	0.8	-1.2	-0.8	-1.1	-0.5	-1.4	-0.9	-0.7	-0.9	-1.8	-1.1	-1.1	0.4	-1.1	-0.8	-1.2	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	2.4	0.0	-0.5	0.7	-1.3	-0.8	-0.7	-0.1	-1.0	-1.5	-0.8	-0.8	-0.9	-0.3	-0.9	-0.1	0.1	-0.1	-0.8	0.1
Qualifications: None of the above	0.2	0.5	1.8	1.2	1.0	0.9	0.1	0.5	0.3	0.9	0.3	0.5	0.5	0.9	0.2	1.2	0.5	-1.4	0.5	0.3	0.3	0.1
Illnesses of siblings	0.2	0.3	1.2	-0.6	-0.2	0.2	-0.2	-0.7	-0.6	0.0	-0.2	-0.8	-0.8	-1.1	-0.4	-0.0	-0.8	-0.8	0.1	-0.4	-0.5	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.8	-1.4	0.2	0.4	0.6	0.4	0.5	-1.0	0.3	0.4	0.1	0.3	0.2	0.1	0.6	1.1	-0.3	0.5	0.5	-0.0
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	0.5	0.5	1.0	0.3	0.2	0.3	-0.1	0.9	1.0	0.1	0.2	0.9	0.6	0.1	-0.1	0.2	0.3	0.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	3.6	-0.7	-0.1	1.9	-0.6	-0.2	-0.4	-0.7	-0.7	-0.5	-0.2	-0.1	-1.0	-0.5	-0.3	1.1	-0.8	0.3	-0.6	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.9	1.7	0.5	0.5	0.5	0.2	0.3	0.6	0.8	0.2	0.4	-0.5	0.5	0.5	0.3	-0.4	1.3	0.3	0.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.5	0.7	-0.2	-0.5	0.6	0.5	0.4	1.2	0.4	0.1	0.6	0.5	0.3	-0.5	0.3	-0.1	0.8	0.2	0.4	0.7
Lung cancer (father)	0.2	0.3	1.4	-0.6	0.0	0.5	0.3	0.3	0.1	-1.1	0.1	0.7	0.1	0.3	0.4	0.1	-0.0	1.2	-0.9	-0.6	0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	3.9	-0.7	-0.2	2.0	-0.6	-0.0	-0.5	-0.9	-0.9	0.0	-0.0	0.1	-0.8	-0.6	-0.2	1.3	-1.0	0.1	-0.7	0.7
Arm fat mass (right)	0.2	0.9	3.8	-1.4	-0.7	-2.0	-1.0	-0.8	-0.5	-0.7	-0.3	-1.0	-0.8	-0.6	-0.8	-0.0	-0.7	-0.3	-1.1	-1.5	-0.5	-1.1
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	0.4	-0.2	-0.3	-0.9	-0.5	-0.7	0.2	-0.1	-0.9	-0.4	-0.6	-1.1	-0.0	-0.7	-0.5	-0.2	-1.1	-0.8	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.5	0.8	0.1	-0.1	-0.3	-0.7	-0.5	0.1	0.5	-0.4	-0.5	-1.2	-0.2	0.3	-0.6	-1.2	1.1	0.1	-0.6	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	-0.3	-1.0	0.0	-0.9	-0.3	-0.7	-0.5	-0.3	-0.6	-0.5	-0.2	-0.8	-0.6	-0.5	0.4	-0.6	-0.5	-0.7	-0.3
High blood pressure (siblings)	0.2	0.2	1.2	0.2	-0.0	0.2	-0.1	0.3	0.2	-0.3	-0.4	0.3	0.4	0.4	-0.1	-0.6	0.5	0.9	-0.1	0.9	0.1	1.1
Leg fat percentage (right)	0.2	0.7	3.3	0.5	0.8	-1.3	-0.0	0.4	0.6	0.5	1.8	0.1	0.6	0.9	0.3	1.5	0.6	-1.3	0.3	-0.7	0.5	-0.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.6	-0.3	0.3	-1.3	1.1	0.4	0.8	0.3	0.5	-0.0	0.3	0.4	0.7	0.5	0.2	-0.2	-0.5	-1.0	1.1	-0.5
Age at first live birth	0.2	0.3	1.4	-0.5	0.1	1.1	-0.2	-0.1	0.3	0.3	-0.2	0.0	0.0	0.2	0.3	-0.1	0.2	1.1	0.4	1.2	0.2	1.2
Angina (self-reported)	0.2	0.3	1.0	0.9	0.5	0.4	0.3	0.4	0.3	0.3	0.0	0.3	0.3	0.7	0.4	0.8	0.4	-0.8	1.0	0.2	0.3	-0.5
Whole body fat mass	0.2	0.7	3.5	-0.9	-0.6	-1.9	-1.2	-0.7	-0.5	-0.4	0.1	-0.9	-0.6	-0.4	-0.8	0.2	-0.6	-0.7	-0.8	-1.5	-0.5	-1.1
Comparative height size at age 10	0.2	0.8	2.9	-1.7	-1.3	-0.8	-0.8	-0.9	-0.8	-0.1	-1.0	-0.4	-0.9	-0.2	-1.1	-0.8	-0.8	0.2	-1.4	-1.2	-0.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.0	-0.2	-0.3	0.3	0.3	0.2	0.0	0.5	0.3	0.6	0.2	-0.4	-0.3	-0.3	0.2	0.9	-0.6	0.3	0.1	1.0
Mineral and other dietary supplements	0.2	0.3	0.7	-0.4	-0.0	-0.0	-0.3	-0.4	-0.5	-0.1	-0.6	-0.7	-0.4	-0.6	-0.9	-0.3	-0.3	0.2	-0.7	-0.6	-0.5	-0.8
Osteoporosis (self-reported)	0.2	0.3	0.8	0.3	-0.9	-0.4	0.1	-0.2	-0.0	0.5	-0.6	-0.8	-0.2	-0.1	0.1	-0.9	-0.2	0.7	-0.2	0.7	-0.0	0.8
Arm fat mass (left)	0.2	1.0	4.6	-1.2	-0.7	-2.1	-1.2	-0.8	-0.6	-0.5	-0.2	-1.1	-0.8	-0.6	-0.9	0.0	-0.7	-0.7	-1.0	-1.5	-0.5	-1.2
Miserableness	0.2	0.4	1.6	-0.6	-1.1	-0.8	0.0	-0.3	-0.2	-1.3	-1.1	-0.5	-0.4	-0.2	-0.1	-0.4	-0.2	1.0	-0.9	0.0	-0.1	-0.2
Commuting to job workplace: Public transport	0.2	0.2	1.2	0.1	0.1	0.4	0.3	-0.0	0.1	-0.3	-1.1	-0.2	-0.3	0.2	0.1	-0.2	-0.2	0.7	0.2	1.0	0.2	0.7
Medication: Blood pressure	0.2	0.4	1.9	-0.6	-0.9	-0.8	-0.7	-0.2	-0.6	-1.4	-0.8	-0.6	-0.5	0.2	-0.6	-0.9	-0.1	0.5	-0.6	0.4	-0.5	-0.4
High cholesterol (Self-reported)	0.2	0.4	1.3	0.2	0.1	-1.1	0.4	0.9	0.4	0.1	0.3	0.6	0.7	1.2	0.5	-0.0	0.9	-0.3	-0.2	-0.9	0.7	-0.7
Leg fat percentage (left)	0.2	0.6	2.1	0.2	0.6	-1.3	0.1	0.6	0.7	0.5	1.4	0.2	0.7	1.2	0.3	1.3	0.8	-0.9	0.3	-0.3	0.7	-0.1
Number of operations (self-reported)	0.2	0.3	1.1	-0.2	-0.2	-0.7	-0.4	-0.7	-0.3	0.3	-0.6	-1.1	-0.7	-0.5	-0.6	-0.4	-0.8	-0.6	-0.3	-0.2	-0.2	-0.2
Diastolic blood pressure, automated reading	0.2	0.7	4.5	2.1	0.9	1.1	0.2	-0.2	0.3	-0.0	0.1	0.6	-0.3	-0.3	0.8	0.0	0.0	-0.6	1.3	1.5	0.1	0.3
Heel T-Score	0.1	1.1	3.6	1.7	1.4	1.8	-0.1	0.2	0.3	1.6	1.2	0.6	0.4	-0.2	0.6	1.2	0.2	-1.5	1.9	0.7	0.2	0.5
Hypothyroidism (self reported)	0.1	0.2	1.4	-0.3	-0.7	0.4	-0.3	-0.0	-0.1	-0.2	-0.3	-0.7	-0.1	0.2	-0.3	-0.4	-0.2	1.2	-0.7	-0.1	-0.1	0.5
Hair Pigment	0.1	2.0	5.0	1.8	2.0	2.2	1.0	1.2	1.2	1.1	2.2	1.2	1.2	1.3	0.8	2.0	1.1	-1.2	1.1	1.1	1.1	0.4
Hearing difficulty/problems: Yes	0.1	0.2	1.7	-0.4	0.4	-0.1	-0.2	0.5	0.2	-0.4	0.4	0.2	0.6	0.1	0.2	1.3	0.2	-0.2	-0.0	-1.0	0.1	-0.1
Medication: Metformin	0.1	0.2	1.3	0.1	-0.4	-0.3	-0.5	-0.2	-0.2	-0.6	-1.2	-0.6	-0.4	-0.2	-0.2	-0.4	-0.1	-0.3	0.1	-0.0	-0.2	-0.9
Trunk fat percentage	0.1	0.6	3.2	-1.0	-0.2	-1.8	-1.1	-0.4	-0.4	-0.2	0.6	-0.5	-0.3	-0.2	-0.6	0.7	-0.4	-0.9	-0.3	-1.3	-0.4	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	1.0	-0.9	0.0	-0.1	0.1	-0.2	-0.2	-0.9	-0.4	-0.1	-0.4	-0.5	-0.2	-0.0	0.1	-0.2	-0.4	-0.1	-0.2	-1.0
Multivitamins +/- minerals	0.1	0.2	1.7	0.0	-0.3	-0.1	-0.1	0.3	-0.2	-1.3	-0.5	0.5	-0.0	-0.0	0.3	-0.3	-0.1	0.4	0.2	0.3	-0.1	0.1
Medication: Atenolol	0.1	0.1	0.6	0.6	0.0	0.8	-0.0	0.4	0.0	-0.2	-0.6	-0.0	0.3	0.3	0.1	-0.1	0.5	0.5	0.3	0.6	-0.0	0.3
Medication: Levothyroxine sodium	0.1	0.2	0.8	0.1	-0.9	-0.2	0.1	0.7	0.2	-0.1	0.1	0.1	0.5	0.5	0.3	-0.5	0.5	0.7	-0.2	0.2	0.3	0.5
Body mass index (BMI)	0.1	0.4	3.6	-0.2	-0.2	-1.9	-0.3	-0.1	0.1	-0.3	0.3	-0.4	-0.1	0.2	-0.0	0.5	-0.0	-0.8	-0.3	-1.1	0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.8	0.1	-0.7	-1.3	0.2	0.2	0.2	-0.1	-1.1	-0.6	-0.0	-0.0	-0.0	-0.3	0.4	0.1	-0.2	0.1	0.3	-0.4
Diabetes (self-reported)	0.1	0.1	0.5	0.4	0.1	-0.0	-0.2	0.6	0.3	0.5	0.2	0.3	0.5	0.7	0.2	0.3	0.6	-0.5	0.2	-0.2	0.3	-0.3
Impedance of arm (right)	0.1	0.5	2.6	-0.2	0.8	1.6	-0.0	0.2	-0.0	0.6	0.5	0.8	0.3	-0.2	-0.0	0.5	0.2	0.2	0.4	1.3	-0.3	1.4
Arm fat percentage (right)	0.1	0.2	1.6	-0.5	0.3	-1.3	-0.1	0.3	0.4	0.2	0.7	0.1	0.4	0.4	0.2	0.7	0.4	-0.4	-0.1	-0.3	0.4	0.0
Hip circumference	0.1	0.6	5.2	-1.2	-1.2	-2.3	-0.7	-0.3	-0.2	-0.0	-0.3	-0.7	-0.2	-0.1	-0.5	-0.2	-0.3	-0.1	-0.8	-1.1	-0.0	-0.5
Noisy workplace	0.1	0.2	0.6	0.3	0.2	0.3	-0.4	0.1	-0.3	-0.0	0.6	0.4	0.3	0.1	-0.2	-0.4	0.5	-0.1	0.1	0.8	-0.5	0.7
Impedance of arm (left)	0.1	0.4	1.1	-0.7	-0.2	0.6	-1.0	-0.6	-0.8	0.2	-0.4	-0.1	-0.4	-0.8	-0.9	-0.4	-0.5	0.3	0.1	1.0	-1.0	1.0
Peak expiratory flow (PEF)	0.1	0.3	1.6	-0.1	0.1	1.3	-0.5	0.0	-0.3	-1.1	0.1	-0.6	-0.0	0.2	-0.4	0.1	-0.3	0.9	-1.0	-0.6	-0.3	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.7	0.3	-0.1	-0.5	0.3	0.4	-0.1	0.8	0.3	0.3	0.4	0.4	-0.2	0.1	0.3	-0.1	-0.5	-0.8	-0.1	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.5	-0.3	0.7	-0.0	0.6	0.1	0.5	0.2	-0.2	0.3	0.1	0.1	0.7	0.1	0.0	0.2	0.3	0.6	0.7	0.3
Body fat percentage	0.1	0.3	2.3	-0.5	0.1	-1.5	-0.6	-0.0	0.1	0.1	0.9	-0.2	0.1	0.3	-0.2	0.9	0.1	-0.8	-0.0	-0.8	0.1	-0.4
Qualifications: College or University degree	0.1	0.4	3.8	1.9	0.4	1.0	0.2	0.1	-0.2	0.5	0.6	0.2	0.1	-0.0	-0.2	0.2	0.0	-0.7	0.6	-0.2	-0.3	-0.2
Migraine (self-reported)	0.1	0.1	0.3	-0.4	-0.5	-0.4	-0.5	-0.3	-0.3	-0.5	-0.5	0.4	-0.4	-0.1	0.1	0.1	-0.3	0.4	-0.2	-0.2	-0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	1.0	0.4	-0.0	0.4	0.1	0.4	-0.0	1.0	-0.1	0.2	0.5	0.3	0.1	0.3	0.2	-0.6	0.8	-0.4	-0.0	0.1
Leg fat mass (right)	0.1	0.5	2.4	-0.1	-0.0	-1.6	-0.9	-0.4	-0.3	-0.1	0.7	-0.6	-0.3	0.0	-0.5	0.7	-0.3	-1.1	-0.5	-1.3	-0.3	-1.0
Arm fat percentage (left)	0.1	0.4	3.4	-0.9	-0.5	-1.9	-0.9	-0.3	-0.2	-0.3	-0.0	-0.6	-0.3	-0.1	-0.4	0.1	-0.2	-0.3	-0.4	-0.6	-0.2	-0.3
Medication for cholesterol	0.1	0.2	0.6	0.7	-0.2	0.1	0.8	0.4	0.5	0.6	-0.2	0.5	0.5	0.1	0.5	-0.2	0.4	0.4	0.6	0.3	0.4	0.7
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.3	0.3	0.5	0.4	-0.1	-0.0	0.0	-0.2	-0.1	0.0	-0.4	-0.0	-0.1	-0.3	0.4	-0.2	0.3	-0.1	0.4
Fractured/broken bones in last 5 years	0.1	0.2	0.8	-0.9	-0.5	-0.2	0.4	-0.1	0.3	-0.5	-0.4	-0.2	-0.2	0.1	0.4	-0.9	-0.1	0.0	0.6	0.4	0.3	-0.2
Impedance of whole body	0.1	0.7	2.2	0.2	1.2	1.5	0.2	0.6	0.3	0.7	1.2	0.9	0.8	0.5	0.2	1.1	0.7	-0.2	1.0	1.1	0.0	1.1
Leg fat mass (left)	0.1	0.4	2.6	-0.3	-0.3	-1.6	-0.8	-0.3	-0.2	-0.2	0.4	-0.6	-0.3	0.1	-0.6	0.5	-0.2	-0.7	-0.6	-1.1	-0.2	-0.8
Bipolar Disorder (2011)	0.0	0.0	0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.5	0.0

Hub : Genes

C19orf54

Models

Trait associations