Best TWAS P=2.38e-16 · Best GWAS P=5.07e-17 conditioned to 0.0102
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | ACTN4 | 0.17 | 0.11 | lasso | 5 | 0.13 | 6.0e-10 | -8.0 | -8.2 | 2.4e-16 | 0.87 | 0.03 | 0.97 | TRUE |
| 2 | GTEx | Muscle Skeletal | ACTN4 | 0.08 | 0.06 | lasso | 3 | 0.05 | 5.9e-06 | -8.0 | -8.1 | 5.8e-16 | 0.94 | 0.03 | 0.96 | FALSE |
| 3 | YFS | Blood | CAPN12 | 0.38 | 0.18 | enet | 59 | 0.29 | 1.8e-96 | 5.5 | -5.1 | 3.1e-07 | 0.43 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LGALS7B | 0.22 | 0.15 | enet | 7 | 0.16 | 4.7e-08 | 3.4 | -6.0 | 2.6e-09 | 0.71 | 0.04 | 0.96 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CAPN12 | 0.10 | 0.00 | blup | 39 | 0.04 | 3.4e-03 | 4.1 | -6.3 | 3.4e-10 | 0.53 | 0.01 | 0.14 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CAPN12 | 0.11 | 0.06 | enet | 13 | 0.10 | 5.4e-11 | 4.5 | 6.2 | 4.3e-10 | -0.50 | 0.30 | 0.68 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | LGALS7 | 0.03 | 0.00 | blup | 33 | 0.02 | 2.5e-03 | 1.2 | 5.2 | 2.3e-07 | -0.70 | 0.03 | 0.75 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CAPN12 | 0.06 | 0.06 | lasso | 2 | 0.06 | 1.2e-06 | 5.5 | -5.5 | 3.7e-08 | 0.54 | 0.76 | 0.08 | FALSE |