Best TWAS P=2.21e-24 · Best GWAS P=2.49e-24 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | CALCRL | 0.16 | 0.17 | lasso | 2 | 0.15 | 8.4e-09 | 10.2 | 9.8 | 1.7e-22 | 0.95 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Tibial | CALCRL | 0.27 | 0.33 | lasso | 3 | 0.32 | 1.1e-25 | 10.2 | 10.2 | 2.2e-24 | 0.99 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Brain Frontal Cortex BA9 | AC007319.1 | 0.16 | 0.08 | lasso | 7 | 0.10 | 9.9e-04 | 7.3 | 6.6 | 3.9e-11 | 0.73 | 0.25 | 0.29 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | TFPI | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.6e-03 | 7.6 | 7.7 | 1.4e-14 | 0.65 | 0.36 | 0.42 | FALSE |
| 5 | GTEx | Nerve Tibial | CALCRL | 0.09 | 0.04 | enet | 9 | 0.08 | 5.2e-06 | 10.2 | 9.8 | 8.4e-23 | 0.90 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | AC007319.1 | 0.17 | 0.10 | lasso | 3 | 0.13 | 1.9e-07 | 6.1 | 6.5 | 1.0e-10 | 0.65 | 0.81 | 0.16 | FALSE |
| 7 | GTEx | Testis | AC007319.1 | 0.33 | 0.22 | lasso | 6 | 0.30 | 1.2e-13 | 6.1 | 5.1 | 2.8e-07 | 0.53 | 0.82 | 0.17 | FALSE |
| 8 | NTR | Blood | CALCRL | 0.02 | 0.03 | lasso | 7 | 0.02 | 3.6e-08 | 7.2 | -6.9 | 6.0e-12 | -0.74 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | TFPI | 0.08 | 0.04 | blup | 51 | 0.03 | 6.0e-03 | 6.1 | 5.3 | 1.3e-07 | 0.60 | 0.03 | 0.35 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CALCRL | 0.03 | 0.04 | blup | 62 | 0.04 | 1.4e-05 | 8.0 | -7.5 | 9.1e-14 | -0.76 | 0.87 | 0.11 | FALSE |