Best TWAS P=6.16e-20 · Best GWAS P=2.44e-117 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RBM45 | 0.03 | 0.00 | bslmm | 475 | 0.00 | 3.0e-01 | -1.5 | 5.8 | 8.9e-09 | 0.13 | 0.14 | 0.07 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TTN | 0.22 | 0.21 | bslmm | 542 | 0.22 | 5.2e-26 | 8.0 | -8.0 | 1.1e-15 | 0.03 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-171I2.5 | 0.07 | 0.04 | enet | 5 | 0.03 | 1.9e-03 | -5.2 | 6.6 | 4.9e-11 | 0.10 | 0.44 | 0.03 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | OSBPL6 | 0.12 | 0.00 | enet | 9 | 0.02 | 2.2e-02 | 11.3 | -9.1 | 6.2e-20 | -0.28 | 0.07 | 0.04 | TRUE |
| 5 | GTEx | Esophagus Muscularis | FKBP7 | 0.10 | 0.03 | enet | 25 | 0.01 | 8.1e-02 | -1.1 | -8.9 | 5.6e-19 | -0.38 | 0.14 | 0.54 | TRUE |
| 6 | GTEx | Esophagus Muscularis | OSBPL6 | 0.10 | 0.01 | lasso | 7 | 0.02 | 1.8e-02 | 2.6 | -7.2 | 7.8e-13 | -0.40 | 0.09 | 0.51 | TRUE |
| 7 | GTEx | Nerve Tibial | AC009948.5 | 0.15 | 0.08 | enet | 47 | 0.04 | 1.1e-03 | -4.8 | -8.4 | 5.5e-17 | -0.31 | 0.98 | 0.00 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | AC009948.5 | 0.09 | 0.05 | enet | 32 | 0.05 | 8.9e-04 | -4.5 | -7.3 | 2.5e-13 | -0.16 | 0.81 | 0.01 | TRUE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | TTN | 0.17 | 0.14 | bslmm | 539 | 0.15 | 2.9e-18 | 6.6 | -6.6 | 3.6e-11 | 0.03 | 1.00 | 0.00 | TRUE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | PRKRA | 0.07 | 0.10 | enet | 15 | 0.10 | 5.8e-13 | -4.8 | -5.2 | 1.5e-07 | -0.01 | 1.00 | 0.00 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | TTN-AS1 | 0.05 | 0.00 | enet | 16 | 0.01 | 4.1e-02 | 2.5 | 5.7 | 1.5e-08 | 0.41 | 0.35 | 0.21 | TRUE |
| 12 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CCDC141 | 0.21 | 0.09 | blup | 131 | 0.08 | 8.6e-05 | 4.2 | 6.6 | 3.6e-11 | 0.35 | 0.37 | 0.04 | FALSE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FKBP7 | 0.08 | 0.05 | enet | 9 | 0.03 | 2.2e-03 | -4.8 | 5.5 | 3.9e-08 | -0.02 | 0.00 | 0.85 | TRUE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | TTN | 0.04 | 0.01 | lasso | 3 | 0.01 | 5.6e-02 | -4.5 | 8.7 | 2.6e-18 | 0.23 | 0.14 | 0.43 | FALSE |