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chr2:190,357,442-192,254,289

Best TWAS P=6.37e-12 · Best GWAS P=4.46e-11 conditioned to 0.0285

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MFSD6	0.06	0.02	enet	14	0.05	2.6e-06	-5.6	-6.0	2.5e-09	0.80	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	MFSD6	0.11	0.09	enet	13	0.13	1.9e-10	-6.2	-5.6	2.2e-08	0.84	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	HIBCH	0.09	0.09	enet	9	0.09	9.0e-08	-5.4	5.2	1.7e-07	-0.38	0.80	0.16	FALSE
4	GTEx	Adipose Visceral Omentum	NAB1	0.15	0.00	lasso	3	0.00	2.5e-01	-5.0	-5.3	1.3e-07	0.41	0.07	0.08	FALSE
5	GTEx	Adrenal Gland	HIBCH	0.48	0.44	lasso	5	0.43	7.1e-17	-5.4	5.3	1.2e-07	-0.51	0.82	0.18	FALSE
6	GTEx	Artery Aorta	MFSD6	0.30	0.16	enet	17	0.22	1.3e-12	-6.5	-6.4	1.7e-10	0.90	0.00	1.00	FALSE
7	GTEx	Artery Coronary	MFSD6	0.23	0.07	lasso	7	0.05	6.3e-03	-6.4	-6.5	8.0e-11	0.94	0.02	0.88	FALSE
8	GTEx	Brain Caudate basal ganglia	HIBCH	0.17	0.19	lasso	5	0.17	1.7e-05	-5.2	5.4	7.1e-08	-0.50	0.48	0.11	FALSE
9	GTEx	Brain Cerebellar Hemisphere	MFSD6	0.14	0.20	lasso	4	0.13	2.8e-04	-6.6	-6.5	7.9e-11	0.97	0.01	0.98	FALSE
10	GTEx	Brain Cerebellum	MFSD6	0.16	0.13	enet	16	0.12	2.4e-04	-6.2	-6.7	2.5e-11	0.83	0.01	0.96	FALSE
11	GTEx	Brain Putamen basal ganglia	INPP1	0.35	0.10	lasso	26	0.12	9.3e-04	-4.9	-5.1	3.1e-07	0.59	0.19	0.28	FALSE
12	GTEx	Breast Mammary Tissue (Female)	HIBCH	0.10	0.08	lasso	5	0.07	3.7e-03	-5.4	5.8	7.7e-09	-0.59	0.06	0.76	FALSE
13	GTEx	Cells Transformed fibroblasts	TMEM194B	0.13	0.12	enet	13	0.11	6.9e-09	4.7	-5.5	3.7e-08	0.51	0.98	0.02	FALSE
14	GTEx	Heart Left Ventricle	HIBCH	0.20	0.24	enet	10	0.24	8.7e-13	-5.4	5.1	3.0e-07	-0.47	0.83	0.17	FALSE
15	GTEx	Heart Left Ventricle	AC093388.3	0.09	0.00	enet	8	0.00	7.2e-01	4.4	-5.2	2.4e-07	0.49	0.08	0.17	FALSE
16	GTEx	Liver	HIBCH	0.31	0.33	enet	24	0.34	3.9e-10	-5.2	5.4	5.4e-08	-0.62	0.88	0.11	FALSE
17	GTEx	Lung	HIBCH	0.27	0.33	lasso	2	0.32	1.9e-25	-5.4	5.3	8.7e-08	-0.51	0.81	0.19	FALSE
18	GTEx	Muscle Skeletal	HIBCH	0.32	0.32	enet	24	0.32	3.1e-32	-5.4	5.4	7.1e-08	-0.47	0.84	0.16	FALSE
19	GTEx	Pancreas	HIBCH	0.12	0.12	lasso	3	0.11	2.8e-05	-5.4	5.4	8.0e-08	-0.51	0.60	0.23	FALSE
20	GTEx	Pituitary	INPP1	0.32	0.26	lasso	5	0.22	3.6e-06	-4.9	-5.2	1.5e-07	0.67	0.30	0.52	FALSE
21	GTEx	Prostate	HIBCH	0.15	0.07	lasso	5	0.06	1.0e-02	-5.3	5.5	3.1e-08	-0.50	0.13	0.42	FALSE
22	GTEx	Skin Sun Exposed Lower leg	HIBCH	0.17	0.07	lasso	8	0.07	3.2e-06	-5.4	5.4	8.0e-08	-0.50	0.83	0.14	FALSE
23	GTEx	Small Intestine Terminal Ileum	HIBCH	0.20	0.07	enet	25	0.07	1.1e-02	-5.4	6.0	1.7e-09	-0.54	0.14	0.54	FALSE
24	GTEx	Stomach	HIBCH	0.32	0.28	enet	11	0.30	6.2e-15	-5.4	5.3	1.2e-07	-0.49	0.85	0.15	FALSE
25	GTEx	Thyroid	MFSD6	0.12	0.01	lasso	5	0.05	2.0e-04	-5.6	-6.7	2.5e-11	0.83	0.02	0.98	FALSE
26	GTEx	Thyroid	HIBCH	0.23	0.28	lasso	8	0.29	2.2e-22	-5.4	5.8	8.1e-09	-0.59	0.85	0.15	FALSE
27	GTEx	Whole Blood	TMEM194B	0.04	0.00	lasso	2	0.01	5.7e-02	5.6	-5.8	8.4e-09	0.36	0.18	0.29	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	HIBCH	0.28	0.28	enet	18	0.31	4.4e-40	-5.2	5.2	1.8e-07	-0.39	0.89	0.11	FALSE
29	YFS	Blood	HIBCH	0.13	0.12	lasso	4	0.12	1.0e-35	-5.2	5.1	3.1e-07	-0.51	0.90	0.10	FALSE
30	YFS	Blood	TMEM194B	0.01	0.00	blup	363	0.01	5.3e-04	4.7	-5.8	5.4e-09	0.55	0.39	0.09	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	HIBCH	0.09	0.14	enet	7	0.14	1.9e-27	-5.2	5.2	2.5e-07	-0.48	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HIBCH	0.09	0.10	lasso	1	0.08	7.9e-05	-5.4	5.4	8.5e-08	-0.52	0.01	0.97	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HIBCH	0.16	0.15	lasso	3	0.16	2.2e-17	-5.4	5.1	2.9e-07	-0.46	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HIBCH	0.29	0.27	lasso	2	0.27	6.7e-13	-5.4	5.3	1.3e-07	-0.48	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM194B	0.03	0.04	lasso	2	0.04	4.5e-05	-6.4	-6.5	1.1e-10	0.97	0.00	0.97	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MFSD6	0.03	0.00	enet	7	0.01	7.4e-02	-4.7	5.7	1.1e-08	-0.64	0.02	0.50	FALSE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HIBCH	0.25	0.25	lasso	9	0.22	7.4e-10	-5.2	5.5	5.1e-08	-0.53	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM194B	0.09	0.02	blup	41	0.04	6.0e-03	4.7	-6.9	6.4e-12	0.75	0.01	0.80	TRUE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	HIBCH	0.30	0.34	lasso	10	0.34	1.0e-36	-5.4	5.1	2.8e-07	-0.46	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM194B	0.04	0.01	blup	41	0.02	3.8e-03	-4.6	-6.8	1.0e-11	0.77	0.02	0.81	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	MFSD6	0.06	0.05	enet	6	0.06	3.9e-06	-5.6	-6.4	1.9e-10	0.91	0.01	0.99	FALSE