[Hub]/) : Traits : Pulse rate, automated reading :

chr2:190,357,442-192,254,289

Best TWAS P=6.37e-12 · Best GWAS P=4.46e-11 conditioned to 0.0285

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MFSD6 0.06 0.02 enet 14 0.05 2.6e-06 -5.6 -6.0 2.5e-09 0.80 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous MFSD6 0.11 0.09 enet 13 0.13 1.9e-10 -6.2 -5.6 2.2e-08 0.84 0.01 0.99 FALSE
3 GTEx Adipose Subcutaneous HIBCH 0.09 0.09 enet 9 0.09 9.0e-08 -5.4 5.2 1.7e-07 -0.38 0.80 0.16 FALSE
4 GTEx Adipose Visceral Omentum NAB1 0.15 0.00 lasso 3 0.00 2.5e-01 -5.0 -5.3 1.3e-07 0.41 0.07 0.08 FALSE
5 GTEx Adrenal Gland HIBCH 0.48 0.44 lasso 5 0.43 7.1e-17 -5.4 5.3 1.2e-07 -0.51 0.82 0.18 FALSE
6 GTEx Artery Aorta MFSD6 0.30 0.16 enet 17 0.22 1.3e-12 -6.5 -6.4 1.7e-10 0.90 0.00 1.00 FALSE
7 GTEx Artery Coronary MFSD6 0.23 0.07 lasso 7 0.05 6.3e-03 -6.4 -6.5 8.0e-11 0.94 0.02 0.88 FALSE
8 GTEx Brain Caudate basal ganglia HIBCH 0.17 0.19 lasso 5 0.17 1.7e-05 -5.2 5.4 7.1e-08 -0.50 0.48 0.11 FALSE
9 GTEx Brain Cerebellar Hemisphere MFSD6 0.14 0.20 lasso 4 0.13 2.8e-04 -6.6 -6.5 7.9e-11 0.97 0.01 0.98 FALSE
10 GTEx Brain Cerebellum MFSD6 0.16 0.13 enet 16 0.12 2.4e-04 -6.2 -6.7 2.5e-11 0.83 0.01 0.96 FALSE
11 GTEx Brain Putamen basal ganglia INPP1 0.35 0.10 lasso 26 0.12 9.3e-04 -4.9 -5.1 3.1e-07 0.59 0.19 0.28 FALSE
12 GTEx Breast Mammary Tissue (Female) HIBCH 0.10 0.08 lasso 5 0.07 3.7e-03 -5.4 5.8 7.7e-09 -0.59 0.06 0.76 FALSE
13 GTEx Cells Transformed fibroblasts TMEM194B 0.13 0.12 enet 13 0.11 6.9e-09 4.7 -5.5 3.7e-08 0.51 0.98 0.02 FALSE
14 GTEx Heart Left Ventricle HIBCH 0.20 0.24 enet 10 0.24 8.7e-13 -5.4 5.1 3.0e-07 -0.47 0.83 0.17 FALSE
15 GTEx Heart Left Ventricle AC093388.3 0.09 0.00 enet 8 0.00 7.2e-01 4.4 -5.2 2.4e-07 0.49 0.08 0.17 FALSE
16 GTEx Liver HIBCH 0.31 0.33 enet 24 0.34 3.9e-10 -5.2 5.4 5.4e-08 -0.62 0.88 0.11 FALSE
17 GTEx Lung HIBCH 0.27 0.33 lasso 2 0.32 1.9e-25 -5.4 5.3 8.7e-08 -0.51 0.81 0.19 FALSE
18 GTEx Muscle Skeletal HIBCH 0.32 0.32 enet 24 0.32 3.1e-32 -5.4 5.4 7.1e-08 -0.47 0.84 0.16 FALSE
19 GTEx Pancreas HIBCH 0.12 0.12 lasso 3 0.11 2.8e-05 -5.4 5.4 8.0e-08 -0.51 0.60 0.23 FALSE
20 GTEx Pituitary INPP1 0.32 0.26 lasso 5 0.22 3.6e-06 -4.9 -5.2 1.5e-07 0.67 0.30 0.52 FALSE
21 GTEx Prostate HIBCH 0.15 0.07 lasso 5 0.06 1.0e-02 -5.3 5.5 3.1e-08 -0.50 0.13 0.42 FALSE
22 GTEx Skin Sun Exposed Lower leg HIBCH 0.17 0.07 lasso 8 0.07 3.2e-06 -5.4 5.4 8.0e-08 -0.50 0.83 0.14 FALSE
23 GTEx Small Intestine Terminal Ileum HIBCH 0.20 0.07 enet 25 0.07 1.1e-02 -5.4 6.0 1.7e-09 -0.54 0.14 0.54 FALSE
24 GTEx Stomach HIBCH 0.32 0.28 enet 11 0.30 6.2e-15 -5.4 5.3 1.2e-07 -0.49 0.85 0.15 FALSE
25 GTEx Thyroid MFSD6 0.12 0.01 lasso 5 0.05 2.0e-04 -5.6 -6.7 2.5e-11 0.83 0.02 0.98 FALSE
26 GTEx Thyroid HIBCH 0.23 0.28 lasso 8 0.29 2.2e-22 -5.4 5.8 8.1e-09 -0.59 0.85 0.15 FALSE
27 GTEx Whole Blood TMEM194B 0.04 0.00 lasso 2 0.01 5.7e-02 5.6 -5.8 8.4e-09 0.36 0.18 0.29 FALSE
28 ROSMAP Brain Pre-frontal Cortex HIBCH 0.28 0.28 enet 18 0.31 4.4e-40 -5.2 5.2 1.8e-07 -0.39 0.89 0.11 FALSE
29 YFS Blood HIBCH 0.13 0.12 lasso 4 0.12 1.0e-35 -5.2 5.1 3.1e-07 -0.51 0.90 0.10 FALSE
30 YFS Blood TMEM194B 0.01 0.00 blup 363 0.01 5.3e-04 4.7 -5.8 5.4e-09 0.55 0.39 0.09 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma HIBCH 0.09 0.14 enet 7 0.14 1.9e-27 -5.2 5.2 2.5e-07 -0.48 0.01 0.99 FALSE
32 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma HIBCH 0.09 0.10 lasso 1 0.08 7.9e-05 -5.4 5.4 8.5e-08 -0.52 0.01 0.97 FALSE
33 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HIBCH 0.16 0.15 lasso 3 0.16 2.2e-17 -5.4 5.1 2.9e-07 -0.46 0.01 0.99 FALSE
34 The Cancer Genome Atlas Liver Hepatocellular Carcinoma HIBCH 0.29 0.27 lasso 2 0.27 6.7e-13 -5.4 5.3 1.3e-07 -0.48 0.01 0.99 FALSE
35 The Cancer Genome Atlas Lung Adenocarcinoma TMEM194B 0.03 0.04 lasso 2 0.04 4.5e-05 -6.4 -6.5 1.1e-10 0.97 0.00 0.97 FALSE
36 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MFSD6 0.03 0.00 enet 7 0.01 7.4e-02 -4.7 5.7 1.1e-08 -0.64 0.02 0.50 FALSE
37 The Cancer Genome Atlas Pancreatic Adenocarcinoma HIBCH 0.25 0.25 lasso 9 0.22 7.4e-10 -5.2 5.5 5.1e-08 -0.53 0.01 0.99 FALSE
38 The Cancer Genome Atlas Pancreatic Adenocarcinoma TMEM194B 0.09 0.02 blup 41 0.04 6.0e-03 4.7 -6.9 6.4e-12 0.75 0.01 0.80 TRUE
39 The Cancer Genome Atlas Prostate Adenocarcinoma HIBCH 0.30 0.34 lasso 10 0.34 1.0e-36 -5.4 5.1 2.8e-07 -0.46 0.01 0.99 FALSE
40 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM194B 0.04 0.01 blup 41 0.02 3.8e-03 -4.6 -6.8 1.0e-11 0.77 0.02 0.81 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma MFSD6 0.06 0.05 enet 6 0.06 3.9e-06 -5.6 -6.4 1.9e-10 0.91 0.01 0.99 FALSE