Best TWAS P=2.35e-18 · Best GWAS P=1.01e-29 conditioned to 3.29e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | RP11-316O14.1 | 0.52 | 0.34 | lasso | 4 | 0.35 | 6.1e-10 | 7.2 | 7.2 | 7.8e-13 | 0.14 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Cerebellum | RP11-316O14.1 | 0.39 | 0.29 | enet | 10 | 0.30 | 1.7e-09 | 7.4 | 7.1 | 1.2e-12 | 0.18 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Brain Hypothalamus | RP11-316O14.1 | 0.28 | 0.26 | lasso | 4 | 0.17 | 8.1e-05 | 7.3 | 7.3 | 3.6e-13 | 0.15 | 0.38 | 0.04 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RP11-316O14.1 | 0.19 | 0.16 | lasso | 3 | 0.12 | 1.3e-09 | 7.3 | 7.4 | 1.2e-13 | 0.16 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Muscle Skeletal | GLB1L | 0.07 | 0.02 | lasso | 2 | 0.02 | 6.8e-03 | 1.9 | -6.2 | 6.8e-10 | -0.35 | 0.21 | 0.05 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GMPPA | 0.05 | 0.02 | blup | 48 | 0.05 | 5.6e-04 | -5.8 | -7.9 | 2.8e-15 | -0.28 | 0.07 | 0.68 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CHPF | 0.08 | 0.06 | blup | 45 | 0.08 | 2.7e-06 | -5.7 | -6.4 | 2.0e-10 | -0.18 | 0.48 | 0.28 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | OBSL1 | 0.03 | 0.03 | blup | 41 | 0.02 | 1.7e-02 | -5.8 | -6.9 | 6.4e-12 | -0.25 | 0.06 | 0.21 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DES | 0.04 | 0.01 | blup | 43 | 0.03 | 4.6e-04 | 5.7 | -8.7 | 2.3e-18 | -0.59 | 0.01 | 0.66 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | CHPF | 0.08 | 0.04 | enet | 10 | 0.02 | 2.3e-03 | -5.9 | -5.4 | 5.9e-08 | -0.21 | 0.64 | 0.02 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | OBSL1 | 0.08 | 0.02 | enet | 15 | 0.02 | 1.6e-03 | -2.0 | -5.6 | 2.4e-08 | -0.15 | 0.02 | 0.04 | TRUE |