TWAS hub - OBSL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.256	0.0640	8.7e-05	0.086	NA	0.057	NA	0.056	1.2e-06	NA	6.6e-05	NA	8.0e-05
2	GTEx	Thyroid	0.234	0.0740	1.5e-03	0.215	NA	0.200	NA	0.219	2.2e-16	NA	2.9e-15	NA	1.1e-16
3	ROSMAP	Brain Pre-frontal Cortex	0.161	0.0344	5.0e-08	0.153	0.072	0.155	0.149	0.154	3.3e-19	1.6e-09	1.9e-19	1e-18	3.0e-19
4	TCGA	Colon Adenocarcinoma	0.104	0.0500	7.6e-03	0.000	0.026	0.006	NA	-0.005	3.2e-01	1.2e-02	1.3e-01	NA	8.3e-01
5	TCGA	Ovarian Serous Cystadenocarcinoma	0.034	0.0210	9.7e-03	0.032	0.019	0.011	NA	0.018	2.8e-03	1.7e-02	5.6e-02	NA	1.9e-02
6	TCGA	Thyroid Carcinoma	0.082	0.0450	5.4e-03	0.015	0.007	0.025	NA	0.013	1.2e-02	6.5e-02	1.6e-03	NA	1.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Pulse rate, automated reading	5.2	16.8	47.2	3.7	-1.3	2.2	1.3	-6.9	-5.6
Pulse rate	4.9	8.3	25.3	1.9	-1.1	1.9	0.0	-5.0	-4.0
Commuting to job workplace: Cycle	4.0	4.9	10.2	1.7	3.2	1.4	3.1	-0.5	2.1
Bipolar Disorder (2018)	3.1	4.9	12.0	2.1	2.6	3.5	1.4	-2.0	0.5
Commuting to job workplace: Car/motor vehicle	2.9	3.4	5.8	-1.4	-2.4	-2.2	-1.7	0.1	-2.2
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	5.9	1.9	1.3	2.1	2.4	1.4	1.2
Number of full sisters	2.6	3.2	6.7	-1.0	-2.6	-0.2	-2.4	-0.7	-2.3
Knee pain experienced in last month	2.6	4.0	13.2	-1.1	1.4	-0.7	0.5	2.6	3.6
Lung cancer (father)	2.5	3.0	6.4	-2.5	-1.6	-0.3	-1.8	0.5	-2.2
Average weekly red wine intake	2.5	3.7	14.3	0.2	1.9	-1.0	1.1	1.5	3.8
Happiness	2.4	2.9	4.9	-1.2	-2.2	-2.0	-2.1	-0.2	-1.6
Alzheimer’s Disease (in father)	2.3	2.5	7.3	2.7	0.0	1.4	0.8	-1.5	-1.7
Bipolar Disorder (2011)	2.3	2.3	8.7	0.7	3.0	2.1	0.0	0.0	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	4.8	-1.0	-2.2	-0.6	-2.0	1.9	-1.6
Mineral and other dietary supplements	2.2	2.9	9.1	-0.2	-0.3	0.2	-1.7	-3.0	-2.3
Ever taken oral contraceptive pill	2.2	2.4	5.2	-1.3	-2.0	-1.6	-2.3	0.5	-0.9
Past tobacco smoking	2.1	3.9	10.3	-1.2	-3.2	-1.1	-2.0	2.3	-0.8
Wears glasses or contact lenses	2.1	2.5	7.7	1.5	1.0	2.8	1.6	0.6	1.1
Alcohol intake frequency.	2.0	4.6	10.1	-1.5	-2.9	-0.8	-2.3	-0.8	-3.2
Medication: Bendroflumethiazide	2.0	3.1	5.8	1.8	2.1	2.4	2.1	-0.4	0.7
Triglycerides	1.9	3.1	7.5	-1.7	-1.6	-0.7	-2.7	-1.6	-1.8
Hearing aid user	1.9	2.1	4.3	2.1	1.1	1.7	1.3	-1.5	0.2
Multivitamins +/- minerals	1.8	2.3	9.0	-0.6	-1.3	-1.0	-0.2	3.0	1.2
Medication: Atenolol	1.8	2.3	8.2	1.5	-0.2	2.9	0.1	-1.6	-0.9
Pain all over the body in last month	1.8	2.0	6.9	-1.2	-1.8	0.4	-0.1	-0.3	-2.6
Medication: Amlodipine	1.8	2.5	7.8	2.8	1.0	2.0	0.6	-1.3	-0.1
Pulse wave peak to peak time	1.8	2.1	4.1	-1.1	-2.0	-1.5	-1.5	1.6	-0.7
Hypertension (Self-reported)	1.8	4.9	10.7	3.0	0.6	3.3	2.3	-1.4	-1.3
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.3	1.0	1.6	2.1	1.3	0.8	1.9
Age at First Birth	1.7	2.5	4.5	1.1	2.1	0.7	1.8	1.6	1.8
High blood pressure	1.7	4.7	9.4	3.1	1.1	3.0	2.6	-1.4	-0.6
Pulse wave Arterial Stiffness index	1.7	2.0	4.1	1.1	2.0	1.3	1.6	-1.4	0.8
Illnesses of father: None of the above (group 1)	1.7	2.1	4.4	-1.6	-0.7	-1.9	-2.1	1.4	-0.3
Vascular/heart problems diagnosed by doctor	1.7	4.5	9.9	-3.0	-0.9	-3.1	-2.3	1.2	0.7
HbA1C	1.6	1.8	3.7	-0.8	-1.9	-0.3	-1.9	-0.9	-1.3
Vitamin and mineral supplements	1.6	2.1	8.4	0.8	1.5	1.0	0.0	-2.9	-0.8
Townsend deprivation index at recruitment	1.6	2.2	5.4	-2.3	-1.8	1.4	-0.8	0.1	-1.5
Ever smoked	1.6	2.8	6.1	1.2	2.5	1.1	2.4	-0.8	1.2
Irritability	1.6	2.7	6.7	0.7	0.2	2.6	-0.8	-2.0	-2.1
Depressed Affect (Nagel 2018)	1.5	3.1	5.6	0.7	-1.9	2.3	-1.3	1.5	-2.4
Had menopause	1.5	1.9	5.3	0.6	0.8	0.8	2.3	1.3	1.6
Headache pain in last month	1.5	2.5	5.8	1.1	-1.1	1.9	0.9	-1.6	-2.4
Chronic bronchitis/emphysema (mother)	1.5	1.7	5.2	-1.6	-0.6	-1.4	-2.3	-0.1	-0.1
Exposure to tobacco smoke outside home	1.5	2.0	5.1	-0.2	0.6	1.1	1.5	2.3	1.7
Medication: Blood pressure	1.5	2.7	5.0	1.9	-0.7	1.8	0.3	-2.2	-2.0
Smoking status: Previous	1.5	2.2	7.2	0.1	2.7	-0.2	0.4	-2.3	0.7
Loneliness, isolation	1.5	2.1	4.5	-0.4	-1.9	0.8	-2.1	1.1	-1.5
Miserableness	1.5	2.5	7.3	0.1	-2.0	1.1	-1.5	-0.2	-2.7
Alzheimer’s Disease (including proxy)	1.4	2.1	3.9	2.0	1.5	1.4	0.5	-2.0	-0.6
Hand grip strength (right)	1.4	3.8	7.8	-0.2	-2.6	-2.8	-1.8	1.1	-2.0
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	5.6	-1.6	0.1	-1.5	-0.3	2.4	1.8
Shortness of breath walking on level ground	1.4	1.6	5.4	2.3	0.8	1.3	1.4	-0.3	-0.1
Long-standing illness, disability or infirmity	1.4	2.1	7.6	0.3	1.4	2.8	0.4	-1.5	-0.9
Osteoarthritis (self-reported)	1.4	1.9	2.7	1.6	1.6	1.1	1.5	0.5	1.5
Alzheimer’s Disease (in mother)	1.3	1.5	5.0	0.5	2.2	1.0	0.4	-1.5	0.7
Diabetes (father)	1.3	1.6	4.5	1.0	-0.9	1.2	0.1	-1.4	-2.1
Hayfever, allergic rhinitis or eczema	1.3	2.8	6.9	-1.4	-2.0	-1.4	-2.6	1.3	-0.2
Supplements: Glucosamine	1.3	1.7	5.8	-0.1	-0.6	-0.6	1.0	2.4	1.6
Time employed in main current job	1.3	1.5	4.0	2.0	1.3	0.5	1.2	-0.3	1.3
Comparative body size at age 10	1.3	3.6	7.2	-1.0	-2.7	-1.1	-2.3	2.4	-1.3
Medication: Seretide 50 evohaler	1.3	1.4	4.1	0.1	-0.3	1.1	-0.7	-2.0	-1.7
Commuting to job workplace: Walk	1.3	1.4	3.3	1.2	0.7	1.8	1.3	-0.5	1.1
Medication: Atorvastatin	1.3	1.6	4.1	0.1	1.3	2.0	1.7	-1.0	0.5
Myopia	1.3	1.9	4.0	-1.9	-1.4	-2.0	-0.7	1.2	-0.3
Number of treatments/medications taken	1.2	2.2	5.8	1.2	1.7	2.4	1.4	0.4	1.1
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	3.2	-0.2	-1.8	-0.4	-1.2	1.8	-0.5
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	4.8	-1.4	0.1	-2.2	-0.9	-0.5	0.9
Commuting to job workplace: Public transport	1.2	1.4	2.9	0.6	1.5	1.7	0.8	-1.3	0.4
Illnesses of father: High blood pressure	1.2	1.5	5.0	0.9	-0.4	1.0	0.6	-2.2	-1.3
Number of operations (self-reported)	1.2	1.8	5.9	0.9	1.1	2.4	1.7	0.4	-0.3
Alcohol drinker status: Previous	1.2	1.3	3.6	-1.8	-0.6	-0.3	-1.9	-0.7	-0.7
Schizophrenia vs Biploar Disorder	1.1	1.5	4.5	-0.6	-2.1	-1.2	-0.4	0.4	-1.5
Allergy or Eczema	1.1	2.9	4.9	-2.0	-1.9	-1.5	-1.6	2.2	0.5
Lung FVC	1.1	5.6	16.0	2.1	1.0	4.0	1.6	2.9	1.2
Supplements: Zinc	1.1	1.2	2.0	-0.8	-0.5	-1.2	1.1	1.4	1.4
Number of incorrect matches in round	1.1	1.8	5.0	-0.8	-0.6	-2.2	-1.2	-1.5	-1.0
Medication: Simvastatin	1.1	1.6	3.7	-0.2	-1.4	-0.3	-1.1	-1.5	-1.9
Falls in the last year	1.1	1.5	5.3	0.5	1.5	2.3	0.9	0.1	0.7
Number of live births	1.1	1.6	3.9	-1.4	0.1	-0.7	-1.3	2.0	1.1
Prospective memory result	1.1	1.3	4.0	-0.7	-2.0	-0.9	-0.8	0.0	-1.5
Ever had bowel cancer screening	1.1	1.3	4.8	0.1	0.4	0.6	0.0	2.2	1.5
Number of self-reported non-cancer illnesses	1.1	1.8	5.9	1.0	1.1	2.4	1.0	-1.2	-0.7
Medication: Blood pressure	1.1	2.1	5.3	2.0	1.1	2.3	1.3	0.5	0.4
Medication: Lisinopril	1.1	1.4	3.5	-1.5	-1.2	-1.9	-0.7	0.6	0.2
Ever had prostate specific antigen (PSA) test	1.1	1.2	2.2	1.5	1.3	0.9	0.8	-1.0	0.9
Diastolic blood pressure, automated reading	1.1	3.5	14.1	1.0	0.1	0.9	-0.1	-3.8	-2.2
Intelligence (Savage-Jansen 2018)	1.0	3.1	7.3	1.0	2.0	1.0	2.7	-2.2	0.7
Fasting Glucose	1.0	1.2	4.7	0.5	0.3	-0.7	0.2	2.2	1.2
Neuroticism (2016)	1.0	1.5	2.7	1.5	-1.0	1.1	-0.2	-1.4	-1.6
Hand grip strength (left)	1.0	2.5	5.8	0.5	-1.9	-2.4	-0.9	1.2	-1.8
Father’s age at death	1.0	1.4	4.7	0.6	1.5	0.2	2.2	-0.8	0.4
Depression (self-reported)	1.0	1.2	4.0	0.4	-1.4	-0.4	-0.6	-0.7	-2.0
Exposure to tobacco smoke at home	1.0	1.1	3.3	-1.3	-0.8	0.3	-0.4	1.8	-0.8
Pulse wave reflection index	1.0	1.2	3.7	-0.4	1.1	0.1	-0.1	1.4	1.9
Gout (self-reported)	1.0	1.3	3.3	1.8	0.6	1.8	0.0	0.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	1.7	-1.3	-1.3	-1.2	-1.3	0.3	-0.6
Average weekly beer plus cider intake	1.0	1.4	3.9	-0.6	-0.6	-2.0	-0.8	1.7	-0.3
Age started oral contraceptive pill	1.0	1.2	2.6	1.5	0.9	0.6	1.2	-1.6	0.1
Unable to work because of sickness or disability	1.0	1.2	2.7	-1.6	-0.7	0.3	-1.4	0.9	-1.2
Bipolar Disorder or Schizophrenia	0.9	2.2	6.4	1.2	1.6	2.5	0.5	-1.6	-0.0
Prostate Cancer	0.9	1.3	3.4	1.3	-1.8	0.0	-1.0	-0.4	-1.3
Primary Biliary Cirrhosis	0.9	1.3	2.0	1.1	-0.4	1.3	1.3	-0.9	-1.4
Heel T-Score	0.9	6.9	19.3	-1.1	-1.4	-0.5	-1.7	-4.4	-3.9
Lung FEV1/FVC ratio	0.9	4.5	10.9	-0.3	-2.5	-2.1	-1.0	-2.0	-3.3
Angina	0.9	1.2	4.3	1.3	0.7	2.1	0.5	0.3	0.4
Severe depression (siblings)	0.9	1.0	2.5	0.8	0.5	1.2	1.6	0.4	1.2
Pack years adult smoking proportion	0.9	1.4	5.3	-1.3	-0.9	0.5	-2.3	-0.1	-0.6
Fed-up feelings	0.9	1.7	4.0	-0.1	-2.0	1.4	-1.1	1.5	-1.0
Serious illness, injury or assault to yourself	0.9	1.1	3.2	0.2	-0.5	1.4	0.3	-1.1	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	6.2	0.7	0.4	2.5	0.9	1.0	0.3
Allergy	0.9	2.0	5.3	1.5	1.8	0.6	2.3	-0.9	0.3
Medication: Ramipril	0.9	1.1	2.9	1.5	-0.1	1.7	0.2	-0.4	-1.2
Medication: Lansoprazole	0.9	1.1	2.5	0.8	1.5	1.6	0.8	0.1	0.6
Length of working week for main job	0.9	0.9	3.3	-0.8	-0.2	0.6	-1.8	-0.6	-1.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.6	-1.2	-1.2	-0.3	-0.8	0.9	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.9	0.7	-0.1	2.0	-0.4	-1.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.2	-1.0	1.2	0.6	-1.5	0.5	1.0
Illnesses of siblings: Diabetes	0.9	1.1	3.0	-1.7	-1.2	0.4	-0.6	-0.3	-1.4
Qualifications: nursing, teaching	0.9	1.4	3.5	1.2	0.6	-0.2	1.6	-1.9	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.1	-0.3	0.6	1.7	0.4	1.8	1.3
Mother’s age at death	0.9	1.1	4.1	-0.4	1.0	-0.6	0.9	-0.0	2.0
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.6	-1.4	-1.1	-1.6	-0.3	0.8	0.5
High cholesterol (Self-reported)	0.9	1.6	3.9	-0.6	-1.4	0.1	-0.6	-1.7	-2.0
Supplements: Calcium	0.9	1.0	2.2	-0.1	0.1	-1.2	1.1	1.1	1.5
Heart disease (siblings)	0.9	1.1	2.8	0.4	0.9	1.7	0.1	0.3	1.7
Pack years of smoking	0.9	1.3	4.8	-1.3	-0.4	0.6	-2.2	-0.7	-0.3
HDL Cholesterol	0.8	1.3	5.4	0.6	-0.5	-0.1	0.8	2.3	1.0
LDL Cholesterol	0.8	1.3	3.3	0.5	-1.8	-0.5	-0.9	1.4	-0.9
Cardiovascular Disease	0.8	2.6	5.4	1.7	-0.7	1.5	0.8	-2.0	-2.3
Relative age of first facial hair	0.8	1.6	5.4	-0.4	2.3	0.4	0.8	-0.7	1.7
Diabetes (mother)	0.8	1.0	4.1	-0.1	0.0	0.6	0.4	-2.0	-1.2
Taking other prescription medications	0.8	1.3	6.1	1.1	0.6	2.5	-0.1	-0.5	0.1
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.2	1.3	1.5	0.6	0.9	-0.5	0.7
Alcohol usually taken with meals	0.8	1.2	2.2	-0.4	1.1	-1.4	0.4	-1.5	1.2
Impedance of arm (right)	0.8	3.6	10.2	-1.0	1.3	-1.6	2.4	-3.2	0.7
Worrier / anxious feelings	0.8	1.5	2.5	0.3	1.1	1.0	1.5	1.3	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.6	-0.4	0.4	-0.9	-0.1	1.5	1.6
Breastfed as a baby	0.8	1.0	2.5	0.1	-0.4	0.9	0.5	-1.6	-1.5
Angina (self-reported)	0.8	1.1	4.2	1.2	0.7	2.1	0.5	0.3	0.2
Migraine (self-reported)	0.8	1.0	2.1	0.7	-1.4	0.8	-0.5	-0.5	-1.5
Medication: Allopurinol	0.8	1.0	3.6	1.1	0.5	1.9	-0.4	-0.9	0.0
Medication: Omeprazole	0.8	0.9	1.8	-1.0	-0.5	1.3	-1.1	0.2	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.7	0.2	1.4	-0.2	0.1	-0.1	1.9
Medication: Gliclazide	0.8	0.9	2.2	-0.6	0.5	-0.7	-0.7	1.5	1.4
Smoking status: Current	0.8	1.2	5.2	0.5	0.3	1.2	2.3	0.6	-0.1
Depression (Nagel 2018)	0.7	1.0	2.7	0.6	-0.1	1.6	0.9	-1.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.6	5.0	1.2	1.0	0.4	2.2	-1.2	0.8
Neuroticism	0.7	1.6	6.0	1.3	0.1	2.4	1.2	0.1	-0.6
Average weekly spirits intake	0.7	0.8	2.8	0.3	-1.3	0.6	-0.2	-0.2	-1.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.9	0.7	0.1	1.7	0.7	-1.3	-0.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.4	0.6	0.8	1.2	1.2	-1.2	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.9	-0.3	-1.2	0.7	-1.2	-0.8	-1.4
Age when periods started (menarche)	0.7	1.7	5.0	-1.3	-1.0	-2.2	-1.4	-0.6	-0.3
Heart attack	0.7	0.8	1.6	1.2	-1.1	1.3	0.1	0.2	-1.0
Impedance of arm (left)	0.7	3.3	5.9	-1.4	1.2	-2.2	1.8	-2.4	1.5
Birth weight of first child	0.7	1.2	2.7	0.7	1.5	0.9	1.6	-0.1	1.0
Neck or shoulder pain in last month	0.7	1.0	4.7	0.0	0.5	2.2	-0.7	-0.6	-0.2
Leg pain on walking	0.7	0.9	2.6	-0.7	-0.1	-1.3	-0.4	1.6	0.7
Back pain experienced in last month	0.7	1.0	2.2	-1.5	0.9	0.4	-1.1	1.0	0.8
Financial situation satisfaction	0.7	0.8	4.2	-0.0	-0.5	-0.2	-0.5	2.1	0.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.4	1.1	-1.1	1.2	-0.1	0.1	-1.2
Body Mass Index (BMI) (2010)	0.6	0.9	2.6	0.6	-0.8	0.8	-1.6	0.7	-0.7
Mean Putamen Volume	0.6	0.6	2.3	1.5	-0.5	0.8	0.1	0.5	-0.6
Current tobacco smoking	0.6	0.9	3.8	0.1	-0.0	1.0	2.0	0.8	-0.2
Qualifications: CSEs or equivalent	0.6	0.8	2.0	0.4	-1.3	0.1	-0.5	-0.7	-1.4
Forced vital capacity (FVC)	0.6	2.1	5.3	1.6	0.6	1.1	1.5	2.3	0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.0	-1.0	-0.1	-0.6	-0.7	1.4	0.8
Financial difficulties in last 2 years	0.6	0.8	3.5	-0.4	-0.7	0.3	-0.7	1.9	0.1
Alcohol intake versus 10 years previously	0.6	1.0	2.0	-0.3	-0.5	-1.4	-0.8	-1.4	-1.0
Illnesses of mother	0.6	0.8	2.5	0.8	-0.1	0.7	0.8	1.6	0.5
Peak expiratory flow (PEF)	0.6	1.4	3.0	0.2	-1.6	-0.7	-1.7	0.5	-1.3
Loud music exposure frequency	0.6	0.7	1.6	0.8	-0.7	-1.0	-0.5	-0.2	-1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.7	1.6	-1.2	-0.7	0.5	-0.3	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.5	-1.0	-0.2	-0.7	-0.6	-1.6	-0.6
Emphysema/chronic bronchitis	0.6	0.7	2.6	-1.0	0.2	1.6	-0.6	-0.0	-0.3
Medication for pain relief, constipation, heartburn	0.6	1.1	5.3	0.5	-0.0	-0.3	-0.3	-2.3	-1.0
Had major operations	0.6	0.8	2.1	0.1	0.9	1.5	1.1	-0.5	-0.3
Age at last live birth	0.6	0.9	2.0	-0.5	0.5	-1.1	0.3	1.2	1.4
Medication: Aspirin	0.6	0.9	1.4	0.8	0.2	0.9	1.2	1.2	0.9
Mood swings	0.6	1.0	2.6	0.1	-1.0	0.8	-1.6	0.4	-1.3
Alcohol drinker status: Never	0.6	0.7	1.8	-0.3	-1.0	-0.0	-0.9	-0.5	-1.4
Risk taking	0.6	0.9	2.9	-0.2	0.3	-1.1	0.8	1.7	0.8
Impedance of whole body	0.6	3.0	5.8	-1.6	1.3	-1.5	1.7	-2.4	1.7
Neuroticism (Nagel 2018)	0.5	1.2	4.2	0.8	-0.5	2.0	-0.1	0.6	-1.4
Breast Cancer	0.5	1.3	3.1	-0.7	-1.5	-1.8	-0.7	1.1	-0.0
Ovarian Cancer	0.5	0.6	1.8	-0.4	0.3	0.4	0.5	1.3	1.0
Smoking Status	0.5	1.2	3.0	-0.3	1.4	0.2	1.7	-1.5	-0.2
Sensitivity / hurt feelings	0.5	0.9	3.6	0.4	0.9	0.8	0.4	-1.9	-0.4
Medication for hormone replacement therapy	0.5	0.5	2.5	-0.3	-0.5	0.1	-1.6	-0.2	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.0	-0.1	0.5	0.9	0.9	1.0	0.6
High blood pressure (mother)	0.5	0.7	2.7	-0.1	-0.4	0.3	0.2	-1.6	-1.1
Nervous feelings	0.5	1.0	4.1	-0.3	0.9	0.9	0.4	-2.0	0.6
Had other major operations	0.5	0.6	1.4	0.2	0.5	1.1	1.2	0.2	-0.8
Diabetes (self-reported)	0.5	0.8	1.3	-0.5	-0.4	1.1	-0.8	-1.1	-1.2
Fluid intelligence score	0.5	1.1	3.4	0.4	1.1	-0.2	1.9	-0.3	1.1
Medication: Cholesterol lowering	0.5	0.8	2.0	0.9	0.4	1.3	0.2	-1.4	-0.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.0	-1.0	-0.4	-0.9	-1.4	0.1	-0.1
Medication: Paracetamol	0.5	0.8	4.3	-0.2	-0.6	0.0	0.6	2.1	-0.0
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.7	-1.3	-0.7	-1.0	-1.3	0.9	0.2
Number of full brothers	0.5	0.7	1.4	-1.2	-0.5	1.1	-0.3	0.8	-0.6
Wheeze or whistling in the chest in last year	0.5	1.0	3.9	0.5	-0.7	2.0	0.0	1.0	-0.5
Number of children fathered	0.5	0.6	2.0	-0.3	0.3	1.1	-1.4	-0.1	0.1
Health satisfaction	0.5	0.6	1.6	1.0	-0.4	0.9	0.1	-0.3	-1.3
Qualifications: College or University degree	0.5	1.6	3.1	0.7	1.6	0.5	1.8	-1.5	1.1
Eye problems/disorders: None of the above	0.5	0.6	1.9	0.1	1.4	-0.3	0.9	0.4	0.8
Comparative height size at age 10	0.5	2.6	5.9	-0.4	-0.5	-2.1	1.4	2.4	1.7
Supplements: Vitamin C	0.5	0.6	2.6	0.2	-0.1	-0.0	0.7	1.6	0.4
Friendships satisfaction	0.5	0.6	2.1	0.5	1.0	-0.3	0.5	0.0	1.4
Average weekly champagne plus white wine intake	0.5	0.7	1.4	-0.4	-0.5	-1.1	0.3	1.2	1.0
Fractured/broken bones in last 5 years	0.5	0.6	1.8	-0.2	-0.7	0.6	-0.0	-1.0	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.6	-0.4	-0.2	1.6	-0.7	0.6	-0.3
Schizophrenia (2014)	0.4	0.8	3.0	0.4	0.7	0.9	-0.1	-1.7	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.3	0.6	-0.2	-0.6	1.2	0.6	-0.5
Blood Red Count	0.4	3.4	6.8	-0.5	-2.3	-0.2	-1.6	-2.6	-2.4
Systolic Blood Pressure	0.4	2.2	5.9	1.3	1.3	1.3	1.3	-2.4	-0.5
Respiratory disease	0.4	0.9	3.9	-2.0	-0.4	-0.0	-0.4	0.9	0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.5	-1.2	-0.3	0.9	-0.4	1.0	0.7
Systolic blood pressure, automated reading	0.4	1.1	2.9	-0.0	1.1	1.6	0.1	-1.7	-0.0
Average weekly fortified wine intake	0.4	0.5	1.5	0.3	0.8	0.7	0.5	-1.2	-0.2
Maternal smoking around birth	0.4	0.5	1.4	0.4	0.4	0.2	0.5	-1.2	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.8	-1.7	-0.8	-0.8	-0.8	0.1	-0.3
Stomach or abdominal pain in last month	0.4	0.5	2.7	0.1	0.5	1.6	0.3	0.1	-0.2
Medication: Levothyroxine sodium	0.4	0.7	2.1	-0.9	-0.2	-0.5	-1.4	0.8	0.6
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	-0.1	1.0	1.0	0.4	0.2	0.7
Qualifications: None of the above	0.4	0.9	2.7	-1.3	-0.0	0.8	-1.6	0.5	0.5
Mouth/teeth dental problems	0.4	0.6	2.0	1.4	-0.2	0.7	0.5	-0.4	-0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	-0.2	0.3	0.2	-0.9	0.8	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.3	0.6	-1.1	0.2	-0.2	0.2	-1.5
Hair/balding pattern: Pattern 3	0.4	0.5	1.5	-1.2	-0.3	-0.9	-0.7	0.6	0.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.5	0.7	0.3	-0.6	1.1	-1.9	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.2	-1.5	0.0	0.8	-0.6	-0.4	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	4.6	0.8	-0.2	0.6	1.9	2.1	0.6
Age at first live birth	0.4	0.7	1.8	1.1	0.7	-0.2	1.3	0.1	1.0
Medication: Ibuprofen	0.4	0.5	1.3	0.4	1.1	0.1	0.4	0.3	1.1
Suffer from ‘nerves’	0.4	0.6	1.6	0.7	0.4	0.6	1.3	1.0	0.3
Diabetes diagnosed by doctor	0.4	0.7	1.4	-0.0	-0.3	1.0	-1.2	-1.1	-0.7
Medication for cholesterol	0.4	0.6	1.5	-0.4	0.3	-1.1	0.7	-0.2	1.2
Medication: Aspirin	0.4	0.6	1.5	0.7	-0.1	0.6	0.8	1.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.1	1.0	0.0	1.0	0.2	1.4	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	0.4	0.5	0.3	0.6	1.1	0.8
Medication: Paracetamol	0.4	0.6	1.6	0.4	-0.1	0.8	1.1	1.2	-0.1
Cholesterol lowering medication	0.4	0.6	1.3	-0.8	-0.7	0.7	-0.1	-0.8	-1.2
Worry (Nagel 2018)	0.3	0.5	1.6	0.4	0.2	0.8	1.3	0.9	0.3
Ulcerative Colitis (UC)	0.3	0.5	1.0	0.1	-0.0	1.0	0.8	0.9	0.7
Major Depression (MDD)	0.3	0.4	1.6	-1.3	0.7	0.5	0.0	0.0	0.0
Lupus	0.3	0.5	1.5	0.0	-0.9	0.2	-0.2	0.6	-1.2
Ulcerative Colitis	0.3	0.5	1.8	0.3	-0.7	0.7	0.2	1.4	-0.1
BMI	0.3	1.7	6.5	-0.4	-1.0	-0.4	-2.5	0.9	-1.2
Waist Hip Ratio (WHR)	0.3	1.3	4.0	0.7	-0.1	-0.1	1.3	-2.0	-1.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.3	-0.1	0.1	1.1	-1.0	-1.0	-0.5
Chronotype (morning person)	0.3	0.8	1.8	0.3	0.8	0.6	0.4	1.3	1.4
Ever had hysterectomy (womb removed)	0.3	0.4	1.2	-0.3	1.1	0.5	0.4	0.3	0.7
Medication: Co-codamol	0.3	0.3	1.0	0.5	-0.1	0.5	0.4	0.4	-1.0
Impedance of leg (right)	0.3	1.4	3.6	-1.2	0.9	-0.5	1.3	-1.9	1.0
Relative age voice broke	0.3	0.5	2.0	0.0	0.5	0.6	0.7	-1.4	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	0.7	-0.0	1.0	-0.4	0.6	0.7
Sitting height	0.3	2.4	8.3	1.8	0.6	0.5	2.9	0.0	1.6
Body mass index (BMI)	0.3	1.4	4.6	0.1	-0.9	0.2	-2.1	1.2	-1.1
Impedance of leg (left)	0.3	1.3	2.1	-1.4	0.6	-1.1	0.8	-1.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	-1.3	0.1	-0.8	-0.0	0.8	1.2
Neuroticism score	0.3	0.6	1.9	0.5	-0.4	1.4	-0.2	0.0	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.8	0.4	-1.0	-0.5	1.0	1.7	-0.1
Standing height	0.3	3.4	8.5	0.1	1.0	-2.4	2.9	0.2	2.3
Blood clot in the leg (DVT)	0.3	0.4	1.0	-0.7	0.4	0.6	-0.3	-1.0	-0.6
Worry too long after embarrassment	0.3	0.5	1.1	0.7	0.7	0.4	0.7	-1.1	-0.3
Arm predicted mass (right)	0.3	1.5	6.3	0.5	-0.9	-0.9	-0.9	2.5	0.1
Overall health rating	0.3	0.7	1.2	-0.6	-0.6	1.1	-1.1	-0.6	-0.9
Chest pain or discomfort	0.3	0.5	1.6	-1.0	-0.0	0.0	-0.5	1.3	0.2
Illnesses of father: Heart disease	0.3	0.4	1.5	0.7	-0.2	0.7	1.2	0.2	0.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.9	1.0	0.4	0.4	0.2	0.6
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.2	-0.4	-0.4	-0.8	-0.5	-0.7
Ever depressed for a whole week	0.3	0.3	1.1	-1.0	0.1	-0.7	-0.1	0.4	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	-0.6	0.1	0.5	-0.4	-0.9	-0.9
Crohns Disease (2012)	0.2	0.3	1.0	-0.2	-0.0	0.0	-0.8	-0.2	-1.0
Rheumatoid Arthritis	0.2	0.3	1.1	0.1	-1.1	0.5	-0.1	0.4	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.4	0.3	0.5	-0.5	0.6	-0.4
Medication: Metformin	0.2	0.3	0.6	0.5	0.4	0.8	-0.4	0.2	0.6
Leg fat-free mass (left)	0.2	0.8	3.0	0.8	-0.6	-0.9	-0.2	1.7	-0.2
Leg predicted mass (left)	0.2	0.8	2.9	0.9	-0.6	-0.9	-0.3	1.7	-0.2
Hearing difficulty/problems with background noise	0.2	0.4	0.8	-0.6	0.7	0.9	0.6	0.0	0.6
Illnesses of siblings	0.2	0.3	1.3	0.1	0.3	-1.1	-0.1	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.1	1.2	-0.4	-0.0	0.5	1.8	-0.1
Noisy workplace	0.2	0.3	0.8	-0.1	-0.8	0.1	-0.4	0.9	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.8	-0.9	-0.4	-0.2	-0.3	-0.8	-0.5
Asthma	0.2	0.4	0.9	-0.4	-0.7	0.7	-0.9	-0.0	-0.4
Tense / ‘highly strung’	0.2	0.3	1.2	0.7	0.1	0.4	-1.1	0.2	-0.1
Hair/balding pattern: Pattern 4	0.2	0.6	2.1	0.3	0.0	0.4	0.6	0.9	1.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.4	0.2	0.3	1.2	0.2	-0.3	-0.2
Glaucoma (self-reported)	0.2	0.3	1.0	0.5	-0.3	0.1	-0.3	-0.3	-1.0
High blood pressure (siblings)	0.2	0.2	1.2	0.0	-0.3	1.1	-0.4	-0.1	-0.1
Arm fat-free mass (right)	0.2	1.2	4.2	0.5	-0.9	-0.9	-1.1	2.0	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	-0.9	0.6	0.2	-0.2	0.5	0.1
Mean time to correctly identify matches	0.2	0.3	0.9	0.0	0.9	0.6	-0.5	-0.3	0.6
Heart disease (mother)	0.2	0.3	0.7	0.8	0.8	-0.2	-0.2	-0.3	0.5
Family relationship satisfaction	0.2	0.3	0.8	0.3	-0.3	-0.3	0.5	0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.9	0.0	-0.7	-1.4	0.2	-0.3	-0.5
Whole body fat-free mass	0.2	0.9	3.3	0.8	-0.7	-0.8	-0.4	1.8	-0.3
Leg fat-free mass (right)	0.2	1.2	4.0	0.7	-1.0	-1.3	-0.4	2.0	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.7	0.4	0.3	-0.5	0.5	-0.1
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.1	-0.5	0.4	0.8	0.4	-0.2
Asthma (self-reported)	0.2	0.4	1.0	-0.6	-0.8	0.4	-1.0	-0.1	-0.5
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.8	-0.7	-0.2	0.2	0.3	-0.5
Whole body water mass	0.2	0.9	3.1	0.7	-0.7	-0.8	-0.5	1.8	-0.4
Leg predicted mass (right)	0.2	1.2	3.8	0.7	-1.0	-1.2	-0.4	2.0	-0.3
Basal metabolic rate	0.2	1.1	3.4	0.5	-1.0	-1.0	-0.7	1.8	-0.5
Arm fat-free mass (left)	0.2	1.1	3.7	0.4	-1.1	-0.8	-0.9	1.9	-0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.7	-0.4	-0.5	0.3	-0.4	0.0
Arm predicted mass (left)	0.2	1.1	3.6	0.4	-0.9	-0.8	-1.1	1.9	-0.6
Schizophrenia (2018)	0.1	0.2	0.3	-0.4	-0.1	0.4	-0.5	-0.5	-0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.1	0.1	0.7	0.4	0.5	0.1
Reaction Time	0.1	0.3	0.9	0.0	-0.0	0.1	-0.9	-0.4	-0.7
Coronary Artery Disease (CAD)	0.1	0.1	0.6	0.7	0.1	0.1	0.0	0.0	0.0
Blood Eosinophil Count	0.1	0.6	2.2	-0.2	-1.0	-0.3	-0.4	-0.1	-1.5
Blood Platelet Count	0.1	0.8	2.3	-1.0	-1.5	-0.5	-1.0	-0.1	-0.6
Blood White Count	0.1	1.1	2.1	-1.4	-0.4	-1.1	-1.5	-1.0	-0.4
Height	0.1	2.3	6.2	-1.2	-0.5	-2.5	1.9	0.1	1.4
Hypothyroidism (self reported)	0.1	0.2	0.9	-0.4	-0.2	-0.5	-0.9	0.3	-0.0
Tanning	0.1	1.3	3.7	-1.7	-0.6	-0.7	-0.1	1.9	0.8
Trunk fat percentage	0.1	0.5	1.0	-0.9	0.3	-1.0	-0.7	-0.4	0.4
Weight	0.1	0.6	1.7	0.1	-0.5	-0.9	-0.8	1.3	-0.2
Arm fat percentage (right)	0.1	0.6	1.8	-0.7	-0.1	-0.4	-1.4	-0.5	-0.8
Trunk fat-free mass	0.1	0.7	2.8	0.6	-0.7	-0.6	-0.4	1.7	-0.5
Hip circumference	0.1	0.3	0.6	-0.2	0.2	-0.8	-0.8	0.7	0.1
Arm fat mass (right)	0.1	0.5	1.9	-0.4	-0.5	-0.6	-1.4	0.3	-0.7
Trunk predicted mass	0.1	0.7	2.8	0.7	-0.7	-0.5	-0.4	1.7	-0.5
Birth weight	0.1	0.2	0.4	-0.2	-0.6	-0.5	-0.6	0.6	0.2
Body fat percentage	0.1	0.3	0.9	-0.6	0.3	-0.3	-0.9	-0.2	0.2
Leg fat percentage (right)	0.1	0.5	1.9	0.4	0.3	1.4	-1.0	-0.0	-0.4
Leg fat mass (right)	0.1	0.3	1.0	0.3	-0.1	0.2	-1.0	0.8	0.0
Arm fat percentage (left)	0.1	0.5	2.2	-0.7	-0.1	-0.5	-1.5	-0.0	-0.3
Arm fat mass (left)	0.1	0.6	2.0	-0.4	-0.5	-0.6	-1.4	0.8	-0.3
Guilty feelings	0.1	0.1	0.4	-0.6	0.5	0.2	-0.1	-0.1	0.2
Leg fat percentage (left)	0.1	0.5	1.3	0.3	0.3	1.1	-1.1	0.4	-0.1
Pain experienced in last month	0.1	0.2	0.6	0.6	-0.2	-0.8	-0.5	0.3	0.4
Leg fat mass (left)	0.1	0.4	1.3	0.2	-0.1	0.1	-1.1	1.0	0.0
Crohns Disease (2017)	0.0	0.1	0.3	-0.1	0.5	-0.1	-0.2	0.1	-0.0
Hair Pigment	0.0	0.2	0.5	-0.6	0.4	-0.2	-0.7	-0.2	-0.6
Trunk fat mass	0.0	0.2	0.5	-0.3	0.3	-0.7	-0.4	0.0	0.4
Waist circumference	0.0	0.1	0.3	0.5	0.1	0.1	-0.3	-0.3	-0.5
Hair/balding pattern: Pattern 2	0.0	0.1	0.2	0.0	-0.1	0.1	0.4	-0.2	-0.2
Whole body fat mass	0.0	0.1	0.5	-0.3	-0.1	-0.3	-0.7	0.3	0.0
Breast cancer (self-reported)	0.0	0.1	0.1	-0.2	0.1	-0.4	0.3	-0.2	-0.2

Hub : Genes

OBSL1

Models

Trait associations