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chr3:121,346,656-122,929,314

Best TWAS P=8.14e-14 · Best GWAS P=2.92e-14 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	WDR5B	0.07	0.10	lasso	1	0.06	2.4e-03	7.5	7.5	8.1e-14	0.95	0.00	0.92	TRUE
1	GTEx	Esophagus Mucosa	CSTA	0.16	0.17	lasso	3	0.16	1.5e-10	-5.6	5.7	1.2e-08	0.20	1.00	0.00	TRUE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM162A	0.03	0.02	enet	4	0.01	1.1e-02	7.5	-7.4	1.2e-13	-0.95	0.00	0.95	FALSE
4	GTEx	Muscle Skeletal	CCDC58	0.07	0.04	lasso	3	0.03	3.3e-04	7.1	-7.4	1.3e-13	-0.95	0.01	0.98	FALSE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	WDR5B	0.08	0.08	lasso	3	0.07	9.7e-05	7.5	7.2	4.8e-13	0.96	0.00	0.98	FALSE
7	METSIM	Adipose	CCDC58	0.11	0.06	lasso	5	0.06	1.1e-09	7.6	7.1	1.1e-12	0.96	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Stomach Adenocarcinoma	WDR5B	0.11	0.05	lasso	3	0.07	1.4e-05	7.5	7.1	1.7e-12	0.91	0.00	0.99	FALSE
9	YFS	Blood	CSTA	0.40	0.20	enet	75	0.40	2.9e-141	6.7	6.8	9.6e-12	0.59	0.74	0.26	FALSE
18	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR5B	0.05	0.06	lasso	4	0.06	2.9e-07	7.5	6.7	2.7e-11	0.93	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	WDR5B	0.09	0.05	blup	39	0.07	1.3e-07	7.5	6.6	3.2e-11	0.94	0.00	1.00	FALSE
3	GTEx	Heart Left Ventricle	CCDC58	0.11	0.04	lasso	2	0.02	2.2e-02	7.1	-6.6	5.4e-11	-0.94	0.01	0.96	FALSE
6	GTEx	Pancreas	FAM162A	0.19	0.14	lasso	2	0.09	1.1e-04	7.6	-6.4	1.8e-10	-0.95	0.01	0.99	FALSE
2	GTEx	Esophagus Mucosa	CCDC58	0.12	0.08	lasso	6	0.05	5.0e-04	5.0	6.2	4.6e-10	0.74	0.02	0.94	FALSE
5	GTEx	Nerve Tibial	FAM162A	0.07	0.05	lasso	4	0.05	2.1e-04	5.5	-6.2	5.4e-10	-0.81	0.01	0.96	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	CSTA	0.08	0.05	blup	64	0.06	4.7e-07	-5.2	6.0	1.4e-09	0.25	0.62	0.38	FALSE
12	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	WDR5B	0.08	0.00	blup	39	0.04	5.8e-03	5.0	5.8	7.0e-09	0.88	0.01	0.82	FALSE
8	YFS	Blood	CCDC58	0.66	0.49	lasso	20	0.64	9.0e-283	7.6	5.7	1.1e-08	0.87	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	WDR5B	0.11	0.03	enet	17	0.05	3.6e-06	7.5	5.7	1.1e-08	0.67	0.00	0.98	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR5B	0.04	0.03	lasso	5	0.04	2.8e-08	7.5	5.5	2.9e-08	0.89	0.00	1.00	FALSE
10	YFS	Blood	KPNA1	0.03	0.01	lasso	6	0.01	1.7e-05	-5.6	-5.5	3.0e-08	-0.29	0.68	0.01	FALSE
19	The Cancer Genome Atlas	Rectum Adenocarcinoma	WDR5B	0.21	0.08	enet	7	0.09	4.6e-03	7.5	5.4	5.6e-08	0.85	0.01	0.84	FALSE