Hub : Genes

KPNA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0232 0.0099 0.00230 0.001 0.006 0.007 0.007 0.004 0.16000 0.00480 0.00160 0.00240 2.1e-02
2 YFS Blood 0.0309 0.0115 0.00055 0.011 0.009 0.011 0.011 0.014 0.00011 0.00033 0.00011 0.00013 1.7e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 3.0 4.8 6.8 1.7 2.6
Bipolar Disorder or Schizophrenia 0.8 1.9 2.6 -1.1 1.6
Depressed Affect (Nagel 2018) 0.2 0.4 0.4 0.6 0.6
Depression (Nagel 2018) 0.2 0.2 0.4 -0.3 0.6
Intelligence (Savage-Jansen 2018) 0.5 1.4 2.5 -1.6 0.6
Neuroticism (Nagel 2018) 0.1 0.2 0.2 -0.4 0.4
Schizophrenia (2018) 1.8 3.8 7.7 -2.8 -0.1
Schizophrenia vs Biploar Disorder 1.7 2.3 3.6 -1.9 -1.0
Worry (Nagel 2018) 1.2 2.6 3.5 -1.3 -1.9
Alzheimer’s Disease (in mother) 0.6 0.7 1.3 -0.3 1.1
Alzheimer’s Disease (in father) 0.7 0.8 1.1 -0.6 1.1
Alzheimer’s Disease (including proxy) 0.4 0.6 0.6 -0.7 0.8
Crohns Disease (2017) 0.4 0.9 1.8 -0.2 -1.4
Irritable Bowel Disease (IBD) 0.3 0.7 0.8 -0.8 0.9
Ulcerative Colitis (UC) 2.1 4.0 7.0 -1.0 2.6
Major Depression (MDD) 0.0 0.0 0.1 0.1 0.3
Reaction Time 0.7 1.4 2.4 -0.7 1.5
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.9 -0.3 1.0
Breast Cancer 0.2 0.4 0.9 -0.9 -0.0
Ovarian Cancer 0.0 0.0 0.0 0.1 -0.1
Prostate Cancer 0.5 0.7 0.9 -0.9 -0.8
Age at First Birth 0.6 0.8 1.4 1.2 0.5
Bipolar Disorder (2011) 0.7 0.7 0.7 0.8 0.9
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 -0.3 -0.2
Coronary Artery Disease (CAD) 0.3 0.3 0.5 -0.4 0.7
Crohns Disease (2012) 0.4 0.7 1.3 -0.0 -1.2
Mean Putamen Volume 2.2 2.5 3.8 -1.9 1.1
Fasting Glucose 0.7 0.8 1.0 -1.0 -0.8
HbA1C 2.6 2.9 3.9 -2.0 -1.4
HDL Cholesterol 1.6 2.6 5.3 0.0 2.3
LDL Cholesterol 5.9 9.3 14.9 3.9 1.9
Lupus 2.2 3.3 4.0 -2.0 -1.6
Neuroticism (2016) 3.0 4.3 5.9 2.4 1.7
Primary Biliary Cirrhosis 1.3 1.9 2.1 -1.5 -1.3
Rheumatoid Arthritis 1.3 1.9 3.0 0.8 1.7
Schizophrenia (2014) 1.1 2.4 4.3 -2.1 0.7
Triglycerides 0.5 0.9 1.5 1.2 0.5
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.0 0.5
Ulcerative Colitis 2.8 4.0 7.4 -0.8 2.7
Blood Eosinophil Count 1.0 7.4 14.4 -0.6 3.8
Blood Platelet Count 0.7 7.9 11.0 3.3 -2.2
Blood Red Count 0.1 0.5 1.1 1.0 -0.0
Blood White Count 0.4 2.9 4.1 2.0 1.3
Heel T-Score 0.1 1.0 2.0 1.4 0.3
BMI 0.1 0.7 1.5 -0.0 1.2
Height 0.2 3.8 7.5 -2.7 -0.3
Waist Hip Ratio (WHR) 0.4 1.8 3.3 0.4 1.8
Systolic Blood Pressure 2.2 10.9 21.8 0.3 -4.7
Smoking Status 1.1 2.5 4.2 -2.1 0.9
Allergy or Eczema 1.1 2.9 5.6 0.6 2.4
Cardiovascular Disease 0.3 1.2 2.3 0.1 -1.5
Hypothyroidism (self reported) 0.6 1.3 1.5 -1.2 1.0
Respiratory disease 0.3 0.7 1.2 0.5 1.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.5 -0.7 0.6
Lung FEV1/FVC ratio 0.1 0.6 0.7 -0.8 0.9
Lung FVC 0.5 2.5 4.4 -0.8 2.1
Neuroticism 0.0 0.0 0.0 0.0 -0.1
Chronotype (morning person) 0.0 0.0 0.1 0.2 -0.2
Hair Pigment 1.0 28.7 57.3 7.6 -0.2
Tanning 0.1 1.3 2.4 -0.4 1.6
Hand grip strength (left) 0.6 1.6 2.4 -1.6 -0.9
Number of treatments/medications taken 0.2 0.4 0.7 0.4 0.8
Average weekly spirits intake 0.7 0.9 1.7 0.0 1.3
Sensitivity / hurt feelings 1.2 2.1 2.5 1.3 1.6
Frequency of depressed mood in last 2 weeks 0.6 0.9 1.2 0.7 1.1
Hearing difficulty/problems: Yes 2.2 3.4 5.4 -2.3 -1.1
Relative age of first facial hair 0.2 0.4 0.5 -0.5 -0.7
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.1 0.4 -0.1
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 0.2 -0.5
Ever had hysterectomy (womb removed) 1.3 1.5 1.7 1.3 1.1
Systolic blood pressure, automated reading 2.0 5.9 9.1 -1.7 -3.0
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 3.1 -1.8 0.6
Angina 2.9 3.8 6.0 2.4 1.2
Medication for hormone replacement therapy 1.2 1.3 2.3 0.6 -1.5
Vitamin and mineral supplements 0.6 0.8 1.5 1.2 -0.1
Supplements: Zinc 0.2 0.2 0.3 -0.6 0.2
Medication: Co-codamol 1.4 1.6 3.1 0.4 1.8
Medication: Metformin 0.8 1.2 1.9 0.7 1.4
Diabetes (father) 0.1 0.2 0.3 0.5 -0.2
Diabetes (mother) 1.6 2.1 2.9 1.1 -1.7
Severe depression (siblings) 0.5 0.6 1.0 -1.0 0.4
Pack years adult smoking proportion 0.3 0.5 0.9 0.2 -1.0
Impedance of leg (right) 0.0 0.0 0.1 -0.2 -0.1
Leg fat-free mass (left) 0.1 0.3 0.3 -0.5 0.5
Trunk fat percentage 0.1 0.4 0.7 0.8 0.4
Hand grip strength (right) 0.8 2.3 3.7 -1.9 -0.9
Townsend deprivation index at recruitment 0.1 0.1 0.2 0.1 -0.4
Current tobacco smoking 0.7 1.1 1.4 -1.2 0.9
Average weekly fortified wine intake 1.4 1.6 3.0 0.4 -1.7
Maternal smoking around birth 0.1 0.2 0.2 -0.4 0.4
Fed-up feelings 1.1 2.0 2.8 1.0 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.3 -0.4 0.6
Relative age voice broke 0.5 0.7 1.0 -0.6 -1.0
Taking other prescription medications 0.1 0.2 0.3 -0.5 0.3
Age when periods started (menarche) 0.1 0.1 0.3 0.5 0.0
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 2.6 1.6 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 2.7 1.6 0.8
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 2.0 0.7 -1.4
Qualifications: CSEs or equivalent 0.8 1.1 1.5 0.8 -1.2
Serious illness, injury or assault to yourself 0.6 0.8 1.4 1.2 -0.4
High blood pressure 0.5 1.4 2.9 0.0 -1.7
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.9 -0.4 1.7
Multivitamins +/- minerals 0.1 0.1 0.1 -0.3 -0.3
Stomach or abdominal pain in last month 0.2 0.2 0.3 0.5 -0.4
Supplements: Glucosamine 0.1 0.1 0.2 0.4 -0.0
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 -0.2 1.0
Medication: Atenolol 1.5 1.8 3.6 1.9 0.0
Medication: Levothyroxine sodium 1.1 1.9 3.7 -1.9 -0.2
Sitting height 0.5 3.4 6.7 -2.6 0.3
Chronic bronchitis/emphysema (father) 1.3 1.5 2.5 -1.6 -0.8
High blood pressure (mother) 0.5 0.7 1.1 -0.5 -1.1
Body mass index (BMI) 0.1 0.5 0.7 0.5 0.9
Impedance of leg (left) 0.0 0.0 0.0 -0.1 -0.2
Leg predicted mass (left) 0.1 0.3 0.3 -0.6 0.6
Trunk fat mass 0.1 0.3 0.4 0.5 0.6
Waist circumference 0.4 1.4 2.5 0.4 1.6
Number of incorrect matches in round 0.8 1.3 2.6 -0.1 -1.6
Past tobacco smoking 1.8 3.2 5.7 2.4 -0.9
Alcohol usually taken with meals 0.4 0.7 0.8 -0.8 -0.9
Nervous feelings 1.2 2.2 3.3 -1.1 -1.8
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.9 7.7 0.4 2.8
Hearing difficulty/problems with background noise 1.9 3.0 3.5 -1.9 1.6
Hair/balding pattern: Pattern 2 3.1 4.0 7.9 2.8 -0.3
Had menopause 1.0 1.2 2.3 -1.5 -0.3
Had other major operations 1.0 1.2 1.3 -1.1 -1.1
Forced vital capacity (FVC) 0.1 0.4 0.7 -0.8 0.1
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 5.2 2.3 1.6
Ever unenthusiastic/disinterested for a whole week 3.6 4.4 8.7 0.2 2.9
Qualifications: None of the above 1.9 4.1 4.2 2.0 2.0
Financial difficulties in last 2 years 0.5 0.7 0.9 0.7 -1.0
Mouth/teeth dental problems 1.5 2.3 4.5 -0.3 -2.1
Heart attack 0.7 0.9 1.8 1.3 0.2
Allergy 0.2 0.5 1.0 -0.2 -1.0
Pain all over the body in last month 1.2 1.3 2.0 -1.4 0.8
Diabetes (self-reported) 0.8 1.3 2.2 0.6 1.5
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 0.4 0.2
Medication: Ramipril 2.1 2.7 4.8 2.2 0.8
Medication: Simvastatin 0.5 0.7 1.1 1.1 0.5
Fluid intelligence score 0.1 0.2 0.3 0.6 -0.1
Illnesses of siblings 0.3 0.4 0.7 0.8 -0.4
Neuroticism score 0.0 0.0 0.1 0.0 0.3
Weight 0.0 0.2 0.3 -0.4 0.6
Impedance of arm (right) 0.1 0.6 0.8 0.9 -0.7
Arm fat percentage (right) 0.3 1.0 1.3 1.2 0.9
Trunk fat-free mass 0.2 1.1 1.5 -1.2 0.8
Hip circumference 0.3 1.4 2.6 0.5 1.6
Time employed in main current job 2.6 3.0 6.0 -2.5 -0.0
Alcohol intake versus 10 years previously 0.5 0.8 1.6 -0.3 -1.2
Father’s age at death 1.4 1.9 3.7 1.9 -0.3
Worrier / anxious feelings 0.5 0.9 1.9 -1.4 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 2.1 -0.5 1.4
Falls in the last year 0.8 1.0 1.5 -1.2 0.8
Hair/balding pattern: Pattern 3 0.9 1.3 1.4 -1.1 -1.2
Number of live births 1.6 2.3 4.0 2.0 0.7
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 -0.3 0.2
Pulse rate 2.1 3.6 6.8 -0.6 -2.6
Happiness 3.3 4.0 6.8 -2.6 -1.1
Noisy workplace 1.4 1.7 3.1 -1.8 0.5
Qualifications: A levels/AS levels or equivalent 2.1 4.6 9.1 0.2 -3.0
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.3 1.0 -1.1
Mouth/teeth dental problems: Dentures 1.8 3.0 5.6 -0.6 2.4
Asthma 0.1 0.1 0.2 -0.5 0.0
Medication: Ibuprofen (e.g. Nurofen) 3.5 4.4 6.2 2.5 1.6
Medication: Cholesterol lowering 1.7 2.6 4.2 2.1 1.0
Depression (self-reported) 1.1 1.3 2.4 0.5 1.6
Medication: Lansoprazole 0.5 0.5 1.0 1.0 0.3
Prospective memory result 0.1 0.1 0.2 0.5 -0.2
Lung cancer (father) 0.4 0.5 0.9 -0.0 -0.9
Illnesses of mother 0.1 0.1 0.2 -0.4 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.2 -0.4 0.4
Pulse wave Arterial Stiffness index 1.7 1.9 2.2 -1.5 -1.3
Impedance of arm (left) 0.2 1.1 1.1 1.1 -1.1
Arm fat mass (right) 0.1 0.6 0.6 0.7 0.8
Trunk predicted mass 0.1 0.8 1.2 -1.1 0.7
Standing height 0.2 1.9 3.6 -1.9 -0.5
Length of working week for main job 0.4 0.4 0.8 -0.9 0.1
Exposure to tobacco smoke at home 0.2 0.2 0.3 0.3 -0.6
Breastfed as a baby 0.7 0.8 1.1 -1.0 0.7
Tense / ‘highly strung’ 0.7 1.1 1.6 -0.8 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.0 0.1 1.7
Hair/balding pattern: Pattern 4 0.8 2.0 3.9 0.4 -2.0
Birth weight of first child 0.1 0.1 0.3 0.2 0.5
Peak expiratory flow (PEF) 0.2 0.5 1.0 -1.0 -0.2
Pulse wave reflection index 0.1 0.2 0.3 0.6 0.2
Ever highly irritable/argumentative for 2 days 1.2 1.4 1.6 -1.3 1.1
Loud music exposure frequency 1.8 1.9 3.5 -1.9 -0.6
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 3.4 -1.0 -1.8
Mouth/teeth dental problems: Bleeding gums 1.0 1.2 1.4 -1.2 -1.0
Blood clot in the leg (DVT) 0.9 1.1 1.8 1.3 -0.7
Medication: Paracetamol 1.2 2.0 3.1 -0.9 -1.8
Headache pain in last month 0.7 1.2 2.2 1.5 0.4
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.9 -0.9 0.1
Glaucoma (self-reported) 1.0 1.2 2.1 0.6 -1.5
Gout (self-reported) 0.2 0.3 0.4 -0.6 -0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.6 -1.2 0.6
Medication: Amlodipine 1.1 1.6 2.3 -0.9 -1.5
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 -0.7 0.3
Birth weight 0.5 1.0 1.8 -0.5 -1.3
Chronic bronchitis/emphysema (mother) 1.5 1.7 3.5 -1.9 0.0
High blood pressure (siblings) 2.0 2.9 5.8 -2.4 -0.2
Forced vital capacity (FVC), Best measure 0.2 0.7 1.3 -1.1 0.4
Body fat percentage 0.1 0.5 0.5 0.7 0.7
Leg fat percentage (right) 0.3 1.2 2.1 0.5 1.4
Arm fat-free mass (right) 0.1 0.6 1.0 -1.0 0.5
Exposure to tobacco smoke outside home 1.5 2.0 2.3 1.3 -1.5
Comparative body size at age 10 0.6 1.7 2.2 1.5 -1.1
Number of full brothers 0.5 0.6 0.6 -0.7 -0.8
Worry too long after embarrassment 1.1 1.9 2.0 -1.4 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.1 -0.4 0.3
Wheeze or whistling in the chest in last year 0.3 0.5 0.6 -0.8 -0.6
Number of children fathered 0.0 0.0 0.1 0.3 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 4.0 -1.2 -2.0
Age at first live birth 0.5 0.8 1.4 0.5 -1.2
Pulse wave peak to peak time 1.2 1.4 1.5 1.2 1.2
Health satisfaction 0.5 0.6 1.1 -1.1 0.3
Shortness of breath walking on level ground 0.3 0.3 0.4 -0.6 -0.5
Qualifications: College or University degree 0.6 1.8 3.4 -0.5 -1.9
Eye problems/disorders: None of the above 0.2 0.3 0.3 0.5 -0.6
Mouth/teeth dental problems: Loose teeth 1.3 1.6 2.3 0.9 1.5
Emphysema/chronic bronchitis 0.5 0.5 1.0 1.0 0.4
Medication for pain relief, constipation, heartburn 0.3 0.5 0.9 -1.0 -0.2
Neck or shoulder pain in last month 0.5 0.7 0.9 1.0 0.7
Medication: Blood pressure 0.3 0.5 0.6 0.7 -0.8
Angina (self-reported) 3.7 4.8 7.4 2.7 1.5
Migraine (self-reported) 0.4 0.5 0.6 0.8 0.6
Medication: Ibuprofen 4.5 5.3 6.7 2.6 2.0
Medication: Allopurinol 0.1 0.2 0.2 -0.5 0.4
Medication: Omeprazole 0.1 0.1 0.2 -0.0 0.5
Medication: Seretide 50 evohaler 0.4 0.5 0.8 -0.9 0.4
Mean time to correctly identify matches 0.7 1.3 2.5 -0.3 1.6
Heart disease (mother) 1.2 1.4 2.3 -0.7 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 2.7 0.7 -1.6
Whole body fat mass 0.1 0.3 0.4 0.4 0.6
Leg fat mass (right) 0.2 0.7 1.3 0.2 1.2
Arm predicted mass (right) 0.1 0.8 1.1 -1.1 0.6
Pulse rate, automated reading 4.8 15.3 30.7 -0.1 -5.5
Alcohol intake frequency. 0.1 0.3 0.5 0.7 -0.2
Comparative height size at age 10 0.3 1.9 3.8 -1.9 0.1
Number of full sisters 0.3 0.3 0.6 0.8 0.2
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.4 -0.2
Overall health rating 0.3 0.6 1.0 0.4 -1.0
Chest pain or discomfort 0.6 0.8 1.6 -1.3 0.1
Had major operations 0.0 0.0 0.1 -0.0 -0.3
Age at last live birth 1.8 2.6 3.6 1.9 -1.2
Family relationship satisfaction 0.9 1.1 1.4 -1.2 -0.9
Leg pain on walking 0.1 0.2 0.3 0.1 0.6
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 3.9 -2.0 -0.1
Commuting to job workplace: Car/motor vehicle 3.4 3.9 7.4 -0.6 2.7
Illness, injury, bereavement, stress in last 2 years 2.1 2.5 4.6 -2.1 0.7
Medication: Aspirin 2.7 3.5 6.8 2.6 0.4
Supplements: Vitamin C 1.2 1.4 2.9 -1.7 -0.1
Knee pain experienced in last month 0.2 0.2 0.3 0.5 -0.5
Hypertension (Self-reported) 0.6 1.7 3.4 0.3 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.5 -1.2 0.0
Illnesses of father: Heart disease 1.9 2.6 3.8 1.1 2.0
Illnesses of siblings: Diabetes 0.5 0.6 1.1 0.2 1.1
Smoking status: Previous 1.3 1.9 3.3 -1.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.4 -0.6 -0.6
Whole body fat-free mass 0.1 0.8 1.1 -1.1 0.7
Leg fat-free mass (right) 0.1 0.3 0.4 -0.6 0.3
Arm fat percentage (left) 0.3 1.1 1.7 1.3 0.7
Average weekly red wine intake 0.4 0.6 0.8 0.6 0.9
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.8 0.9 -0.6
Mood swings 0.2 0.4 0.7 -0.2 0.8
Loneliness, isolation 1.6 2.2 4.3 -0.3 -2.1
Long-standing illness, disability or infirmity 0.7 1.1 2.3 -1.5 0.1
Ever had bowel cancer screening 1.1 1.3 2.1 -0.6 -1.5
Diabetes diagnosed by doctor 0.5 0.8 1.1 0.7 1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 1.4 0.9 -1.2
Friendships satisfaction 0.8 0.9 1.0 -1.0 -1.0
Qualifications: nursing, teaching 0.9 1.4 2.3 -0.7 -1.5
Commuting to job workplace: Walk 2.7 3.0 3.5 1.9 -1.6
Eye problems/disorders: Cataract 0.3 0.4 0.8 -0.1 0.9
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 0.8 0.1
Medication for cholesterol 0.4 0.5 1.1 0.1 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 1.4 0.8 -1.2
Back pain experienced in last month 3.0 4.4 6.3 2.5 1.6
Mineral and other dietary supplements 0.2 0.2 0.4 0.1 -0.6
Breast cancer (self-reported) 0.9 1.1 2.2 0.0 -1.5
Asthma (self-reported) 0.2 0.3 0.5 -0.7 0.4
Osteoporosis (self-reported) 2.1 2.6 5.1 -2.3 -0.2
Osteoarthritis (self-reported) 0.3 0.4 0.5 0.7 -0.5
Medication: Aspirin 2.6 3.3 6.1 2.5 0.8
Medication: Gliclazide 1.3 1.5 1.8 1.4 1.1
Illnesses of father: None of the above (group 1) 0.9 1.1 1.8 -0.6 -1.3
Smoking status: Current 0.6 1.0 1.7 -1.3 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 0.6 0.2
Whole body water mass 0.2 1.0 1.3 -1.2 0.8
Leg predicted mass (right) 0.0 0.2 0.4 -0.6 0.3
Arm fat mass (left) 0.1 0.4 0.5 0.7 0.5
Number of self-reported non-cancer illnesses 0.3 0.5 0.5 -0.7 0.7
Average weekly champagne plus white wine intake 0.5 0.7 1.2 -1.1 0.4
Miserableness 2.5 4.3 5.2 1.8 2.3
Guilty feelings 0.2 0.3 0.5 -0.7 -0.4
Wears glasses or contact lenses 1.2 1.4 2.0 -0.8 1.4
Ever taken oral contraceptive pill 0.6 0.6 1.1 -1.0 0.4
Hearing aid user 0.2 0.2 0.4 0.1 0.6
Mother’s age at death 0.8 1.0 1.9 0.3 -1.4
Financial situation satisfaction 1.5 1.9 2.4 -1.6 -1.2
Tinnitus: Yes, now most or all of the time 1.6 1.8 3.7 -0.0 1.9
Commuting to job workplace: Public transport 1.4 1.6 2.9 1.7 -0.6
Eye problems/disorders: Glaucoma 0.9 1.1 2.1 0.3 -1.5
Medication: Blood pressure 1.4 2.7 4.5 -0.9 -2.1
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.1 -0.3 -0.1
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.1 0.2 -0.1
High cholesterol (Self-reported) 0.3 0.5 0.6 0.8 0.6
Medication: Bendroflumethiazide 0.7 1.0 1.9 -0.3 -1.4
Medication: Paracetamol 0.5 0.8 1.1 -0.7 -1.1
Medication: Lisinopril 0.9 1.2 2.2 1.5 0.4
Medication: Atorvastatin 1.0 1.3 1.9 1.4 0.8
Illnesses of father: High blood pressure 0.1 0.1 0.1 -0.2 -0.3
Alcohol drinker status: Never 1.2 1.4 2.2 1.5 -0.8
Ever smoked 1.5 2.7 4.8 -2.2 0.8
Basal metabolic rate 0.1 0.6 0.7 -0.9 0.7
Leg fat percentage (left) 0.3 1.1 1.8 0.6 1.3
Arm fat-free mass (left) 0.2 1.0 1.2 -1.1 0.8
Number of operations (self-reported) 0.1 0.2 0.3 -0.6 -0.1
Average weekly beer plus cider intake 0.4 0.6 1.1 -1.1 0.2
Irritability 0.2 0.3 0.6 -0.8 0.3
Risk taking 0.8 1.1 1.5 1.2 0.9
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.7 -0.9 -0.5
Fractured/broken bones in last 5 years 0.2 0.2 0.5 0.0 0.7
Age started oral contraceptive pill 0.2 0.3 0.6 0.8 -0.1
Diastolic blood pressure, automated reading 3.9 12.1 23.6 -0.8 -4.9
Ever depressed for a whole week 0.5 0.6 0.9 0.4 1.0
Unable to work because of sickness or disability 0.6 0.8 1.6 -0.3 -1.2
Commuting to job workplace: Cycle 1.9 2.3 4.2 -2.1 -0.6
Myopia 1.0 1.4 2.2 0.8 -1.5
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.3 -0.6 1.5
Cholesterol lowering medication 0.4 0.5 0.9 0.4 1.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.1 -0.4 -0.4
Pain experienced in last month 1.6 2.7 3.7 -1.3 -1.9
Supplements: Calcium 5.2 5.7 10.7 -3.3 0.9
Basal cell carcinoma (self-reported) 4.8 5.7 11.3 0.4 -3.4
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.3 1.5 0.4
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.0 1.0 -0.9
Heart disease (siblings) 1.3 1.6 3.0 0.5 1.7
Alcohol drinker status: Previous 2.5 2.9 5.0 -2.2 0.9
Pack years of smoking 0.2 0.3 0.7 0.1 -0.8
Impedance of whole body 0.1 0.5 0.6 0.6 -0.8
Leg fat mass (left) 0.2 0.7 1.2 0.3 1.1
Arm predicted mass (left) 0.2 0.8 0.8 -0.9 0.9