Best TWAS P=2.26e-46 · Best GWAS P=7.64e-109 conditioned to 3.96e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | GJA1 | 0.13 | 0.07 | enet | 14 | 0.13 | 2.9e-10 | 7.5 | 14.3 | 2.3e-46 | 0.51 | 0.87 | 0.10 | TRUE |
| 4 | METSIM | Adipose | GJA1 | 0.06 | 0.01 | bslmm | 348 | 0.03 | 4.0e-05 | 11.5 | 14.1 | 5.3e-45 | 0.42 | 0.38 | 0.10 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | GJA1 | 0.19 | 0.05 | lasso | 4 | 0.05 | 4.1e-05 | 4.1 | -8.5 | 2.5e-17 | -0.20 | 0.74 | 0.04 | TRUE |
| 2 | GTEx | Esophagus Mucosa | GJA1 | 0.25 | 0.05 | lasso | 10 | 0.11 | 8.5e-08 | 4.1 | 7.5 | 7.3e-14 | 0.40 | 0.84 | 0.02 | TRUE |
| 5 | METSIM | Adipose | TBC1D32 | 0.05 | 0.01 | bslmm | 423 | 0.02 | 4.7e-04 | 3.7 | 6.4 | 2.0e-10 | 0.19 | 0.51 | 0.06 | TRUE |
| 6 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf170 | 0.05 | 0.01 | blup | 116 | 0.04 | 1.7e-03 | 4.7 | -6.1 | 1.1e-09 | -0.04 | 0.20 | 0.11 | TRUE |