TWAS hub - TBC1D32

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2970	0.0980	3.6e-03	-0.006	NA	0.000	NA	-0.005	5.9e-01	NA	3.1e-01	NA	4.9e-01
2	GTEx	Nerve Tibial	0.2444	0.0623	1.1e-05	0.061	NA	0.156	NA	0.147	4.2e-05	NA	3.4e-11	NA	1.3e-10
3	GTEx	Skin Sun Exposed Lower leg	0.0990	0.0430	5.0e-03	0.022	NA	0.028	NA	0.042	5.9e-03	NA	2.2e-03	NA	2.1e-04
4	GTEx	Thyroid	0.1570	0.0520	3.6e-04	0.065	NA	0.034	NA	0.053	1.0e-05	NA	1.2e-03	NA	6.1e-05
5	METSIM	Adipose	0.0549	0.0228	1.0e-03	0.011	0.015	0.006	0.02	0.012	6.9e-03	0.0022	3.3e-02	0.00047	5.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Pulse rate	5.3	8.9	30.1	1.6	1.5	3.1	-0.0	5.5
Medication: Lisinopril	4.7	6.0	7.4	2.4	2.2	2.7	2.5	2.4
Illnesses of father: High blood pressure	4.2	5.2	7.5	2.2	2.1	2.7	2.0	2.2
Diabetes (mother)	4.1	5.2	9.6	1.9	2.0	3.1	2.5	1.6
Commuting to job workplace: Cycle	4.0	4.8	6.7	-2.6	-2.2	-2.4	-1.3	-2.3
Pain all over the body in last month	3.9	4.2	5.8	2.1	1.8	2.3	1.5	2.4
Mean Putamen Volume	3.7	4.2	5.6	2.0	1.7	2.4	2.3	1.8
Pulse rate, automated reading	3.1	10.0	40.4	1.1	0.7	2.4	-1.6	6.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.7	6.8	-2.3	-2.6	-1.8	-1.6	-0.7
Diabetes diagnosed by doctor	3.0	5.0	5.8	1.6	2.3	2.4	2.4	2.4
Medication: Co-codamol	2.8	3.2	4.7	1.7	2.2	1.9	1.9	1.0
Medication: Metformin	2.6	3.7	4.7	1.9	1.9	2.2	1.7	1.9
Diabetes (father)	2.6	3.2	4.6	1.6	2.0	2.1	1.1	1.9
Alcohol usually taken with meals	2.6	4.2	7.0	1.8	2.3	2.2	2.6	1.0
Medication: Amlodipine	2.6	3.7	4.9	2.2	2.2	1.9	1.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	4.0	1.8	2.0	1.7	1.7	1.4
Loud music exposure frequency	2.5	2.7	3.3	-1.3	-1.7	-1.6	-1.8	-1.8
Mineral and other dietary supplements	2.5	3.3	9.8	1.6	1.4	1.5	0.0	3.1
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	6.0	0.9	1.3	1.4	2.4	1.6
Qualifications: CSEs or equivalent	2.4	3.2	7.1	-1.2	-2.3	-1.3	-2.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	10.1	-1.9	-1.7	-2.2	-1.4	-3.2
Intelligence (Savage-Jansen 2018)	2.2	6.9	11.3	2.6	3.4	2.7	2.7	1.4
Maternal smoking around birth	2.1	3.1	6.5	2.0	1.9	1.2	-0.2	2.5
Diabetes (self-reported)	2.1	3.2	5.4	1.0	1.7	2.0	2.3	1.7
Chest pain or discomfort	2.1	3.0	7.5	2.7	1.9	1.7	0.7	0.8
Number of self-reported non-cancer illnesses	2.1	3.7	7.8	2.8	1.8	2.0	0.6	1.7
Fractured/broken bones in last 5 years	2.1	2.7	3.7	1.7	1.7	1.9	1.1	1.7
Pain experienced in last month	2.1	3.5	5.1	-2.2	-1.7	-2.3	-1.2	-1.9
Hair/balding pattern: Pattern 4	2.0	4.9	7.1	-2.3	-2.0	-2.5	-1.4	-2.7
Leg pain on walking	1.9	2.3	5.0	-2.2	-2.0	-1.4	-0.8	-0.6
Basal cell carcinoma (self-reported)	1.9	2.3	6.0	1.3	0.7	1.6	0.6	2.4
Smoking status: Current	1.8	2.8	4.4	-1.6	-2.1	-1.5	-2.1	-0.8
Verbal and Numeric Reasoning (VNR)	1.7	4.0	6.9	1.6	2.6	1.9	2.0	1.6
Hearing difficulty/problems: Yes	1.7	2.7	4.4	1.3	1.7	1.9	2.1	0.9
Depressed Affect (Nagel 2018)	1.6	3.4	5.0	2.2	2.2	1.7	1.3	1.6
Father’s age at death	1.6	2.2	3.3	-0.8	-1.1	-1.6	-1.8	-1.7
High blood pressure (siblings)	1.6	2.3	4.3	1.6	1.5	2.1	1.4	0.6
Wheeze or whistling in the chest in last year	1.6	2.9	6.8	-0.4	-1.6	-1.7	-2.6	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	2.0	5.3	-0.9	-1.3	-1.4	-2.3	0.2
Friendships satisfaction	1.6	1.9	4.0	2.0	1.4	1.6	1.0	0.3
Current tobacco smoking	1.5	2.4	3.8	-1.5	-1.9	-1.3	-1.9	-0.9
Medication: Ramipril	1.5	1.9	3.1	1.6	1.4	1.3	-0.1	1.8
Noisy workplace	1.5	1.9	3.7	-1.9	-1.1	-1.5	-1.5	0.2
High blood pressure	1.4	3.8	5.6	1.9	2.4	2.1	1.8	1.5
Supplements: Vitamin C	1.4	1.7	2.5	-0.9	-1.6	-1.4	-1.0	-1.4
Eye problems/disorders: Glaucoma	1.4	1.6	3.6	1.9	1.6	1.1	0.8	0.3
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.5	1.6	1.2	1.5	0.5	1.3
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.7	0.5	1.9	1.4	1.9	1.8
Taking other prescription medications	1.3	2.0	4.9	1.4	1.1	1.4	0.0	2.2
Hair/balding pattern: Pattern 3	1.3	2.0	3.4	0.8	1.6	1.3	1.4	1.9
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.8	-1.0	-1.2	-1.3	-1.7	-0.8
Hypertension (Self-reported)	1.3	3.5	5.4	1.9	2.3	1.9	1.5	1.6
Loneliness, isolation	1.3	1.8	3.1	1.1	1.5	1.1	1.2	1.8
Reaction Time	1.2	2.2	8.0	0.5	-1.1	-0.7	-2.8	1.1
Medication for hormone replacement therapy	1.2	1.4	2.2	1.1	0.9	1.5	1.2	1.2
Vitamin and mineral supplements	1.2	1.6	3.0	0.9	1.3	1.3	1.1	1.7
Chronic bronchitis/emphysema (father)	1.2	1.4	2.5	-1.6	-1.1	-1.6	-0.9	-0.4
Fluid intelligence score	1.2	2.4	3.7	1.2	1.9	1.7	1.5	1.3
Smoking status: Previous	1.2	1.8	3.1	1.4	1.8	1.3	1.5	-0.4
Long-standing illness, disability or infirmity	1.2	1.9	3.0	1.7	1.1	1.3	0.6	1.7
Breast cancer (self-reported)	1.2	1.4	4.9	0.6	1.0	0.9	0.2	2.2
Vascular/heart problems diagnosed by doctor	1.2	3.2	4.2	-1.7	-2.1	-1.9	-1.7	-1.5
Alcohol drinker status: Previous	1.2	1.3	2.3	-1.4	-1.0	-1.0	-0.8	-1.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.5	1.3	0.9	1.0	-0.2	1.9
Medication: Lansoprazole	1.1	1.2	2.2	-0.9	-1.3	-0.6	-1.1	1.5
Medication: Blood pressure	1.1	2.0	2.9	1.7	1.7	1.4	1.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.2	-1.8	-1.1	-1.2	0.1	-2.3
Financial situation satisfaction	1.1	1.3	2.0	-0.8	-1.3	-1.0	-1.4	-1.1
Diastolic blood pressure, automated reading	1.1	3.5	10.2	1.6	1.2	1.8	-0.3	3.2
Number of treatments/medications taken	1.0	1.8	5.1	1.3	0.9	1.2	0.1	2.2
Hearing difficulty/problems with background noise	1.0	1.7	2.7	1.5	1.1	1.6	1.4	0.5
Average weekly red wine intake	1.0	1.5	3.0	1.1	1.2	1.1	1.7	0.8
Miserableness	1.0	1.8	3.8	1.9	1.8	1.2	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	2.2	1.4	0.8	1.3	0.2	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.5	1.6	1.1	1.1	0.0	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.2	1.2	0.5	1.5	1.2	1.3
Medication: Omeprazole	0.9	1.0	3.4	0.9	0.6	0.8	-0.0	1.8
Family relationship satisfaction	0.9	1.1	1.8	1.4	0.9	1.3	-0.2	1.1
Ever had bowel cancer screening	0.9	1.0	1.6	0.5	1.2	1.1	1.2	0.8
Commuting to job workplace: Public transport	0.9	1.1	1.6	1.2	0.9	1.2	0.1	1.3
Coronary Artery Disease (CAD)	0.8	1.0	2.2	-1.1	-0.5	-1.0	-0.6	-1.5
Fasting Glucose	0.8	0.9	2.8	-0.7	-0.9	-0.7	-0.3	-1.7
HDL Cholesterol	0.8	1.4	2.6	-0.9	-1.6	-0.9	-1.1	-1.3
Hand grip strength (left)	0.8	2.0	8.1	-1.0	-0.3	-0.7	0.4	-2.9
Relative age of first facial hair	0.8	1.7	4.8	-2.2	-1.4	-1.1	-0.6	-0.6
Multivitamins +/- minerals	0.8	1.0	1.6	-0.7	-0.8	-1.2	-1.3	-0.8
Hair/balding pattern: Pattern 2	0.8	1.0	1.8	-1.4	-1.4	-0.8	-0.8	-0.4
Mouth/teeth dental problems: Dentures	0.8	1.3	1.7	1.2	1.3	1.3	1.2	0.6
Neck or shoulder pain in last month	0.8	1.2	3.9	2.0	1.1	0.6	-0.5	0.4
Osteoporosis (self-reported)	0.8	1.0	4.4	-0.1	-0.2	0.1	-0.6	2.1
Guilty feelings	0.8	1.3	3.1	-1.1	-0.4	-1.8	-0.1	-1.4
Ever depressed for a whole week	0.8	1.0	1.7	1.3	0.4	1.2	0.7	1.0
Schizophrenia vs Biploar Disorder	0.7	0.9	2.0	-0.9	-1.0	-0.8	-0.2	-1.4
Hypothyroidism (self reported)	0.7	1.7	4.8	1.2	0.8	1.1	0.4	2.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.7	-1.0	0.0	-0.2	1.3	-1.3
Alcohol intake versus 10 years previously	0.7	1.0	2.1	0.6	1.5	0.8	1.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	-0.8	-0.9	-1.0	-1.2	-0.8
Exposure to tobacco smoke at home	0.7	0.8	2.6	-1.6	-0.8	-0.7	0.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.1	-1.4	-1.5	-0.9	-0.7	-0.7
Medication: Aspirin	0.7	0.9	2.3	0.4	1.0	0.9	0.4	1.5
Qualifications: nursing, teaching	0.7	1.1	2.0	1.4	0.8	0.9	1.2	-0.8
Medication: Aspirin	0.7	0.9	2.4	0.3	1.0	0.9	0.6	1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.8	1.2	0.9	1.3	0.3	0.5
Age started oral contraceptive pill	0.7	0.9	1.7	-0.2	-0.9	-1.0	-1.3	-1.1
Crohns Disease (2017)	0.6	1.2	2.4	1.1	1.5	0.5	0.5	1.4
Irritable Bowel Disease (IBD)	0.6	1.3	2.3	1.5	1.4	0.4	-0.2	1.5
Age at First Birth	0.6	0.9	4.2	-0.1	-0.0	-0.3	0.0	-2.1
Angina	0.6	0.8	1.9	0.1	1.1	0.8	1.4	0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.8	0.3	-0.5	-0.4	-1.7	0.1
Allergy	0.6	1.3	4.3	-1.2	0.0	-1.0	0.1	-2.1
Pulse wave reflection index	0.6	0.7	1.9	-0.6	-0.6	-1.4	-0.3	-0.9
Glaucoma (self-reported)	0.6	0.7	1.8	1.1	1.3	0.4	0.6	0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.2	1.0	0.6	1.1	1.0	1.5
Eye problems/disorders: None of the above	0.6	0.7	2.6	-1.6	-0.5	-0.5	-0.5	-0.3
Medication for pain relief, constipation, heartburn	0.6	1.1	3.6	-0.7	-0.6	-1.0	0.2	-1.9
Migraine (self-reported)	0.6	0.8	1.8	-0.3	-1.3	-0.3	-1.0	-0.9
Heart disease (mother)	0.6	0.7	1.5	0.7	0.6	1.2	0.8	0.7
Overall health rating	0.6	1.2	2.3	1.3	0.8	1.1	-0.2	1.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.2	-0.6	-0.4	-1.1	-1.0	-0.9
Ever taken oral contraceptive pill	0.6	0.6	2.3	-0.3	-0.6	-0.6	-1.5	-0.3
Medication: Blood pressure	0.6	1.2	2.5	0.8	1.1	1.3	1.6	0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.3	-0.3	-0.4	-0.4	0.7	-1.8
Supplements: Calcium	0.6	0.7	1.3	0.6	1.0	0.4	1.1	0.9
Heart disease (siblings)	0.6	0.7	2.2	-0.6	-0.8	-0.6	-1.5	-0.2
Alzheimer’s Disease (in father)	0.5	0.6	1.2	1.0	0.4	1.1	0.1	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	1.0	0.7	1.2	0.7	0.4
Rheumatoid Arthritis	0.5	0.7	1.2	-1.0	-0.6	-0.9	-1.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	0.9	0.8	0.7	0.7	0.4
Number of incorrect matches in round	0.5	0.8	1.6	0.7	0.4	1.1	1.3	0.6
Mouth/teeth dental problems	0.5	0.7	1.5	-1.0	-0.8	-1.2	-0.4	-0.4
Number of live births	0.5	0.7	2.1	0.2	0.1	1.1	0.6	1.4
Prospective memory result	0.5	0.7	1.0	-0.5	-0.6	-0.9	-1.0	-1.0
Tense / ‘highly strung’	0.5	0.8	1.8	0.0	-0.8	-0.6	-1.2	-1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.2	0.4	0.1	0.0	-1.5	0.7
Blood clot in the leg (DVT)	0.5	0.6	1.8	0.1	-0.8	-0.6	-1.3	0.5
Emphysema/chronic bronchitis	0.5	0.5	1.5	0.9	0.3	0.2	-0.4	1.2
Angina (self-reported)	0.5	0.6	1.4	-0.1	0.8	0.6	1.2	0.8
Mean time to correctly identify matches	0.5	1.0	3.3	0.2	-0.9	-0.5	-1.8	0.7
Medication for cholesterol	0.5	0.7	1.8	-0.5	-0.8	-0.9	-1.3	-0.2
Wears glasses or contact lenses	0.5	0.6	2.2	0.4	0.1	0.5	1.5	0.5
Hearing aid user	0.5	0.6	1.2	-0.9	-0.8	-0.5	-0.1	-1.1
Medication: Bendroflumethiazide	0.5	0.8	1.6	1.3	0.9	0.9	0.8	0.2
Alcohol drinker status: Never	0.5	0.5	0.9	0.7	0.7	1.0	0.7	0.5
Average weekly beer plus cider intake	0.5	0.7	1.3	-0.9	-0.3	-1.1	-1.1	-0.6
Crohns Disease (2012)	0.4	0.6	0.9	-0.7	-0.4	-1.0	-0.8	-0.9
Neuroticism (2016)	0.4	0.6	1.3	0.9	0.3	0.8	-0.3	1.2
Ulcerative Colitis	0.4	0.6	1.5	1.2	1.0	0.5	-0.2	0.7
Cardiovascular Disease	0.4	1.2	2.5	1.4	1.6	0.8	-0.0	0.8
Chronotype (morning person)	0.4	1.0	1.5	-0.6	-0.9	-1.1	-1.2	-1.0
Hand grip strength (right)	0.4	1.0	4.5	-0.3	0.2	-0.1	0.6	-2.1
Medication: Simvastatin	0.4	0.5	1.1	0.5	1.0	0.5	1.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.3	-1.2	-0.6	-1.1	-0.8	-1.8
Qualifications: College or University degree	0.4	1.4	2.6	1.6	1.2	1.1	0.4	1.1
Suffer from ‘nerves’	0.4	0.6	0.9	-0.4	-0.9	-0.7	-1.0	0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	1.0	0.7	0.4	0.3	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	0.8	0.7	0.7	0.8	0.5	0.9
Mood swings	0.4	0.8	1.4	0.9	1.2	1.1	0.7	0.2
Back pain experienced in last month	0.4	0.6	2.1	0.6	0.7	0.4	-0.2	1.5
Mother’s age at death	0.4	0.5	1.0	-1.0	-0.3	-0.6	0.0	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	0.3	-0.6	-0.4	-1.1	0.6
Depression (Nagel 2018)	0.3	0.5	2.2	0.1	0.4	0.3	-0.1	1.5
Breast Cancer	0.3	0.7	2.3	0.0	0.9	0.5	1.5	-0.5
Waist Hip Ratio (WHR)	0.3	1.3	2.7	-1.3	-0.9	-1.6	-0.9	-0.7
Systolic Blood Pressure	0.3	1.3	4.1	-0.9	-0.5	-1.1	-0.1	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.6	0.4	0.3	0.4	-0.2	1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	0.7	-0.1	0.8	0.3	1.3
Medication: Levothyroxine sodium	0.3	0.6	1.3	0.3	0.6	0.6	0.8	1.1
Had other major operations	0.3	0.4	1.4	-0.0	-0.6	-0.3	-1.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.9	1.4	0.4	1.0	0.6	-0.4
Qualifications: None of the above	0.3	0.7	1.7	-1.3	-0.7	-0.8	-0.6	-0.3
Time employed in main current job	0.3	0.3	0.7	0.1	0.8	0.3	0.7	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.1	0.6	0.3	0.4	-0.7	1.0
Happiness	0.3	0.3	0.9	1.0	0.5	0.5	0.3	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	0.5	0.0	0.9	1.1	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	-0.6	-0.9	-0.4	-0.1	-0.4
Birth weight of first child	0.3	0.5	0.9	-0.7	-0.9	-0.3	-0.4	-0.9
Peak expiratory flow (PEF)	0.3	0.6	1.2	-0.7	-0.4	-1.1	-0.7	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	4.1	-0.7	-0.4	-0.7	-0.2	-2.0
Number of children fathered	0.3	0.4	1.2	0.1	0.0	0.3	0.7	-1.1
Medication: Allopurinol	0.3	0.4	1.4	-1.2	-0.1	-0.6	-0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.2	-0.2	-0.6	-0.2	-1.1	0.4
Leg fat-free mass (right)	0.3	1.3	1.8	-1.0	-0.9	-1.3	-1.2	-1.3
Asthma (self-reported)	0.3	0.6	1.2	1.0	-0.1	0.6	-0.8	1.1
Osteoarthritis (self-reported)	0.3	0.4	1.4	0.3	0.2	0.0	0.5	-1.2
Average weekly champagne plus white wine intake	0.3	0.5	1.9	-0.1	-0.2	-0.0	-0.6	1.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.5	-0.2	0.2	0.3	1.2	0.1
Medication: Paracetamol	0.3	0.5	1.9	0.5	0.3	0.6	-0.1	1.4
Myopia	0.3	0.5	1.4	-0.5	-0.0	-0.8	-0.2	-1.2
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.7	-0.2	-0.4	0.0	-0.8
Worry (Nagel 2018)	0.2	0.5	1.0	-0.4	-1.0	-0.6	-0.8	-0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.2	0.2	0.6	0.8	-0.1
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.8	0.3	-0.2	-0.8	0.7
Major Depression (MDD)	0.2	0.2	0.5	-0.2	0.1	0.4	0.6	0.7
Ovarian Cancer	0.2	0.3	0.8	-0.6	0.5	-0.2	0.9	-0.3
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.2	-0.3	-0.7	-0.5	-0.0
HbA1C	0.2	0.3	0.6	0.8	0.2	0.6	0.2	-0.5
Primary Biliary Cirrhosis	0.2	0.3	1.2	1.1	0.1	0.5	-0.3	0.4
Schizophrenia (2014)	0.2	0.4	1.5	0.4	0.1	0.7	1.2	0.2
Triglycerides	0.2	0.4	1.1	0.3	1.1	0.4	0.7	0.3
Heel T-Score	0.2	1.2	4.5	1.0	-0.3	0.5	0.7	-2.1
Height	0.2	3.7	16.1	-0.5	-0.7	-1.1	0.7	-4.0
Respiratory disease	0.2	0.5	1.0	0.7	-0.5	-0.1	-1.0	0.9
Lung FEV1/FVC ratio	0.2	1.2	2.9	-1.7	-1.1	-0.7	-0.8	0.9
Sensitivity / hurt feelings	0.2	0.4	1.0	-0.2	-0.6	-0.6	-1.0	0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.0	0.0	-0.0	0.5	1.0	-0.2
Systolic blood pressure, automated reading	0.2	0.7	1.5	-0.8	-0.8	-0.8	-0.4	-1.2
Severe depression (siblings)	0.2	0.3	0.7	-0.1	-0.7	-0.4	-0.8	-0.2
Pack years adult smoking proportion	0.2	0.2	0.5	0.6	0.4	0.2	-0.7	0.5
Impedance of leg (right)	0.2	0.9	1.4	0.9	1.0	1.1	1.2	0.7
Leg fat-free mass (left)	0.2	1.1	1.5	-0.9	-0.8	-1.2	-1.2	-1.1
Townsend deprivation index at recruitment	0.2	0.2	0.4	-0.4	-0.2	-0.4	-0.5	-0.7
Fed-up feelings	0.2	0.4	1.1	1.1	0.9	0.2	-0.3	0.2
Stomach or abdominal pain in last month	0.2	0.3	0.8	0.9	0.2	0.2	-0.9	0.1
Supplements: Glucosamine	0.2	0.3	0.8	0.5	0.2	0.2	0.5	-0.9
Sitting height	0.2	1.2	5.0	0.3	0.5	-0.7	0.6	-2.2
Body mass index (BMI)	0.2	0.7	2.2	0.2	0.1	0.2	-1.1	1.5
Leg predicted mass (left)	0.2	1.2	1.7	-0.9	-0.8	-1.3	-1.3	-1.1
Past tobacco smoking	0.2	0.3	0.6	-0.7	-0.6	-0.3	0.1	0.8
Forced vital capacity (FVC)	0.2	0.8	3.5	-0.4	-0.3	-0.6	0.0	-1.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.2	-0.8	0.0	-0.5	-0.1
Financial difficulties in last 2 years	0.2	0.2	0.4	-0.6	-0.1	0.1	-0.6	0.6
Heart attack	0.2	0.2	0.5	-0.1	-0.4	-0.7	-0.6	0.0
Neuroticism score	0.2	0.4	0.8	0.9	0.7	0.5	0.5	-0.1
Worrier / anxious feelings	0.2	0.4	1.1	0.4	0.4	0.8	1.1	0.3
Falls in the last year	0.2	0.3	0.8	0.6	0.0	0.9	0.6	0.4
Asthma	0.2	0.4	0.8	0.7	-0.4	0.3	-0.8	0.9
Depression (self-reported)	0.2	0.3	0.7	-0.9	-0.6	-0.5	-0.2	-0.1
Lung cancer (father)	0.2	0.3	0.7	-0.0	0.5	0.3	0.8	0.5
Standing height	0.2	2.1	8.4	-0.8	-0.5	-1.1	0.4	-2.9
Length of working week for main job	0.2	0.2	0.6	-0.7	-0.5	-0.2	-0.5	0.0
Breastfed as a baby	0.2	0.2	0.4	-0.3	-0.6	-0.6	-0.3	-0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.3	0.3	0.4	0.9	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	-0.1	-0.5	-0.1	-0.7	-0.9
Medication: Paracetamol	0.2	0.3	0.9	0.4	0.2	0.6	-0.0	0.9
Headache pain in last month	0.2	0.4	0.7	-0.2	-0.7	0.2	-0.8	0.8
Gout (self-reported)	0.2	0.3	0.8	-0.9	-0.1	-0.6	-0.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.3	0.2	-0.5	-0.5	0.8
Birth weight	0.2	0.4	1.4	-0.7	-1.2	-0.1	-0.0	-0.2
Leg fat percentage (right)	0.2	0.7	2.3	0.6	0.3	0.5	-0.7	1.5
Exposure to tobacco smoke outside home	0.2	0.3	1.1	0.0	-0.2	-0.1	-1.1	0.5
Comparative body size at age 10	0.2	0.7	1.9	0.4	0.6	0.6	1.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.7	-0.4	0.6	0.2	0.7
Age at first live birth	0.2	0.4	1.4	0.5	0.1	-0.2	-0.5	-1.2
Pulse wave peak to peak time	0.2	0.2	0.3	0.6	0.2	0.6	-0.2	-0.5
Medication: Ibuprofen	0.2	0.2	0.3	-0.3	-0.5	-0.5	-0.6	-0.2
Medication: Seretide 50 evohaler	0.2	0.3	0.6	-0.0	-0.6	-0.3	-0.6	-0.8
Alcohol intake frequency.	0.2	0.4	0.8	-0.8	0.4	0.4	0.9	-0.5
Number of full sisters	0.2	0.3	0.4	0.4	-0.5	0.6	-0.5	0.6
Had major operations	0.2	0.2	0.3	-0.6	-0.4	-0.2	-0.4	-0.5
Age at last live birth	0.2	0.3	1.1	0.5	-0.3	-0.1	-1.1	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.5	-0.6	-0.6	0.0	-0.4
Knee pain experienced in last month	0.2	0.3	1.4	0.0	-0.4	-0.3	-1.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.2	-0.4	-0.4	-0.8	0.5
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.0	-0.6	-0.6	-0.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.7	-0.5	-0.8	-0.3	-0.6	-0.6
Medication: Gliclazide	0.2	0.2	0.5	-0.4	-0.2	-0.5	-0.1	-0.7
Leg predicted mass (right)	0.2	1.2	1.6	-1.0	-0.9	-1.3	-1.2	-1.2
Medication: Atorvastatin	0.2	0.2	0.5	0.2	-0.2	-0.3	-0.7	0.6
Irritability	0.2	0.4	1.1	1.1	0.5	0.4	-0.4	-0.6
Unable to work because of sickness or disability	0.2	0.3	0.8	0.5	0.1	0.4	0.4	0.9
Pack years of smoking	0.2	0.3	0.7	0.7	0.8	0.5	-0.1	0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.5	-0.4	-0.1	0.7	-0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.8	0.5	0.4	-0.0	0.6
Schizophrenia (2018)	0.1	0.2	0.9	-0.1	-0.4	0.2	1.0	-0.1
Lupus	0.1	0.1	0.5	-0.0	0.3	-0.7	-0.0	-0.3
Blood Eosinophil Count	0.1	0.7	1.3	0.7	0.7	1.1	1.1	-0.5
Blood Red Count	0.1	0.6	1.2	-1.1	0.6	-0.8	0.2	1.0
Blood White Count	0.1	0.9	2.4	0.5	1.5	0.2	1.3	-0.4
BMI	0.1	0.7	2.2	0.5	0.8	0.4	-0.6	1.5
Smoking Status	0.1	0.3	1.3	0.2	0.0	0.0	-0.3	-1.1
Allergy or Eczema	0.1	0.4	1.2	0.6	-0.4	-0.0	-0.3	1.1
Lung FVC	0.1	0.7	1.6	0.5	0.7	0.9	1.3	-0.5
Neuroticism	0.1	0.4	1.0	1.0	0.3	0.3	-0.7	0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.3	0.4	-0.2	0.5	-0.3
Supplements: Zinc	0.1	0.1	0.4	-0.3	0.1	0.2	0.7	-0.1
Trunk fat percentage	0.1	0.2	0.6	0.2	0.0	0.0	-0.6	0.8
Average weekly fortified wine intake	0.1	0.1	0.2	0.1	-0.4	0.3	-0.4	0.4
Relative age voice broke	0.1	0.2	0.4	0.6	0.3	0.6	0.1	0.4
Age when periods started (menarche)	0.1	0.3	0.5	0.6	0.7	0.6	0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.7	-0.1	0.4	-0.0	-0.7
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.4	-0.1	-0.5	-0.5	-0.2
Medication: Atenolol	0.1	0.1	0.2	-0.1	0.5	0.1	0.1	0.4
Impedance of leg (left)	0.1	0.4	0.8	0.6	0.6	0.8	0.9	0.3
Waist circumference	0.1	0.3	1.0	-0.3	-0.3	-0.6	-1.0	0.3
Nervous feelings	0.1	0.2	0.6	-0.1	-0.5	-0.5	-0.8	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.4	-0.7	-0.2	0.2	0.3
Illnesses of siblings	0.1	0.2	0.5	0.2	0.6	-0.1	0.7	0.1
Impedance of arm (right)	0.1	0.3	1.1	0.2	0.1	-0.1	0.7	-1.0
Arm fat percentage (right)	0.1	0.4	1.0	0.5	-0.1	0.2	-1.0	0.8
Trunk fat-free mass	0.1	0.4	1.3	-0.3	-0.2	-0.5	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.7	-0.4	-0.3	-0.5	-0.3	-1.3
Medication: Cholesterol lowering	0.1	0.2	0.5	-0.3	-0.0	-0.4	-0.3	-0.7
Illnesses of mother	0.1	0.1	0.3	-0.2	0.1	-0.4	0.0	0.5
Pulse wave Arterial Stiffness index	0.1	0.2	0.3	-0.5	-0.2	-0.6	0.1	0.4
Impedance of arm (left)	0.1	0.3	0.7	-0.4	-0.4	-0.5	0.6	-0.8
Arm fat mass (right)	0.1	0.3	0.9	0.3	-0.1	0.1	-0.9	0.8
Trunk predicted mass	0.1	0.4	1.3	-0.2	-0.2	-0.5	-0.6	-1.1
Body fat percentage	0.1	0.3	1.1	0.3	0.1	0.2	-0.6	1.1
Number of full brothers	0.1	0.1	0.3	-0.5	-0.1	0.4	0.4	0.1
Shortness of breath walking on level ground	0.1	0.1	0.2	0.5	0.1	0.2	-0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	0.0	-0.6	0.1	-0.1	-0.6
Leg fat mass (right)	0.1	0.4	1.5	-0.1	-0.3	-0.3	-1.2	0.8
Comparative height size at age 10	0.1	0.4	1.6	-0.2	0.0	-0.5	0.2	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	-0.3	0.1	0.1	0.7	0.3
Whole body fat-free mass	0.1	0.7	1.4	-0.6	-0.5	-0.8	-0.8	-1.2
Arm fat percentage (left)	0.1	0.5	1.4	0.1	-0.4	-0.1	-1.2	0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	-0.1	0.3	0.3	0.4
Commuting to job workplace: Walk	0.1	0.1	0.2	0.2	0.3	0.4	0.2	0.2
Whole body water mass	0.1	0.5	1.3	-0.5	-0.4	-0.7	-0.8	-1.1
Arm fat mass (left)	0.1	0.3	1.0	0.0	-0.3	-0.1	-1.0	0.8
High cholesterol (Self-reported)	0.1	0.2	0.6	0.8	0.8	0.1	-0.1	-0.0
Ever smoked	0.1	0.2	0.6	0.8	0.3	0.3	-0.4	-0.5
Basal metabolic rate	0.1	0.5	0.8	-0.5	-0.4	-0.8	-0.9	-0.9
Leg fat percentage (left)	0.1	0.5	1.6	0.5	0.3	0.4	-0.7	1.3
Risk taking	0.1	0.1	0.2	0.3	0.3	0.1	-0.4	0.5
Cholesterol lowering medication	0.1	0.1	0.2	0.1	0.4	-0.2	0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.1	-0.2	-0.6	-0.3	0.1
Leg fat mass (left)	0.1	0.4	1.6	-0.1	-0.3	-0.3	-1.3	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	0.3	0.1	-0.1	-0.1	0.0
LDL Cholesterol	0.0	0.0	0.1	-0.1	-0.2	0.1	0.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.1	0.1	-0.3	-0.3	-0.2
Blood Platelet Count	0.0	0.5	0.9	0.9	0.6	-0.4	-0.4	-1.0
Hair Pigment	0.0	0.2	0.6	-0.8	-0.1	0.3	-0.3	0.5
Tanning	0.0	0.3	0.8	0.2	0.0	-0.9	-0.7	-0.5
Average weekly spirits intake	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1	0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.2	0.3	-0.1	-0.1	0.1
High blood pressure (mother)	0.0	0.0	0.2	0.1	-0.0	0.2	-0.4	0.1
Trunk fat mass	0.0	0.1	0.5	0.1	-0.0	-0.1	-0.7	0.3
Had menopause	0.0	0.0	0.2	0.1	0.0	0.1	0.4	0.1
Weight	0.0	0.2	0.8	-0.2	-0.1	-0.4	-0.9	0.1
Hip circumference	0.0	0.1	0.3	0.6	0.2	0.2	-0.5	-0.1
Arm fat-free mass (right)	0.0	0.2	0.4	-0.5	-0.2	-0.5	-0.5	-0.6
Worry too long after embarrassment	0.0	0.1	0.2	0.5	0.3	-0.0	0.1	-0.2
Health satisfaction	0.0	0.1	0.2	-0.2	-0.2	0.0	-0.4	-0.1
Whole body fat mass	0.0	0.2	0.5	0.2	-0.0	0.1	-0.7	0.7
Arm predicted mass (right)	0.0	0.2	0.2	-0.4	-0.1	-0.5	-0.5	-0.4
Illnesses of father: Heart disease	0.0	0.0	0.1	-0.1	-0.3	-0.1	0.0	0.2
Arm fat-free mass (left)	0.0	0.1	0.2	0.2	0.2	-0.0	-0.3	-0.4
Number of operations (self-reported)	0.0	0.0	0.2	-0.2	0.1	0.1	-0.0	-0.4
Impedance of whole body	0.0	0.2	0.9	0.1	0.2	0.2	1.0	-0.3
Arm predicted mass (left)	0.0	0.1	0.1	0.3	0.3	0.1	-0.2	-0.4

Hub : Genes

TBC1D32

Models

Trait associations