TWAS hub - KLHL42

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.175	0.0452	1.9e-05	0.156	NA	0.128	NA	0.140	2.7e-12	NA	3.2e-10	NA	4.5e-11
2	GTEx	Esophagus Muscularis	0.316	0.0540	2.5e-09	0.184	NA	0.152	NA	0.159	2.4e-11	NA	1.7e-09	NA	6.4e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Diabetes (self-reported)	7.8	12.0	23.8	-4.9	-0.4
Diabetes diagnosed by doctor	7.0	11.4	22.2	-4.7	-0.8
Pulse rate, automated reading	6.4	20.6	41.0	6.4	-0.5
Diabetes (father)	6.3	7.8	14.3	-3.8	1.2
Type 2 Diabetes (T2D) (2012)	5.7	6.6	12.7	-3.6	0.7
Medication: Gliclazide	5.6	6.3	10.9	-3.3	-1.3
Type 2 Diabetes (T2D) (2018)	5.1	9.5	18.5	-4.3	-0.7
Pain all over the body in last month	4.9	5.3	10.5	0.0	-3.2
HbA1C	4.7	5.3	9.3	-3.0	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	4.2	4.9	5.4	-2.3	-2.1
Ever depressed for a whole week	4.2	5.2	10.2	-3.2	-0.5
Lung FEV1/FVC ratio	3.9	19.7	24.7	-5.0	-3.8
Pulse rate	3.7	6.3	8.2	2.9	2.1
Medication: Metformin	3.6	5.0	10.0	-3.2	-0.1
Medication: Seretide 50 evohaler	3.4	3.9	7.7	-2.8	0.4
Alcohol drinker status: Never	3.3	3.9	4.7	-2.2	-1.8
Medication: Paracetamol	3.2	5.3	9.5	3.1	1.0
Medication: Simvastatin	3.1	4.6	8.2	-2.9	-1.0
Medication: Ibuprofen	3.1	3.7	4.0	2.0	1.9
Illnesses of siblings: Diabetes	3.0	3.7	6.7	-2.6	-0.9
Age started oral contraceptive pill	3.0	3.8	5.8	-2.4	-1.3
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	5.0	2.2	1.5
Hearing difficulty/problems with background noise	2.8	4.5	6.4	-2.5	-1.6
Medication: Aspirin	2.8	3.7	6.4	-2.5	-1.0
Tinnitus: Yes, now most or all of the time	2.8	3.3	5.2	-2.3	-1.2
Diabetes (mother)	2.7	3.4	3.6	-1.9	-1.8
Medication: Paracetamol	2.7	4.2	7.9	2.8	0.6
Hearing difficulty/problems: Yes	2.6	4.0	7.9	-2.8	-0.3
Medication: Cholesterol lowering	2.6	4.0	7.8	-2.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	5.5	0.2	2.4
Osteoporosis (self-reported)	2.6	3.3	5.9	-0.8	2.4
Lung FVC	2.5	12.7	17.3	2.9	4.2
Angina	2.5	3.3	6.3	-2.5	-0.5
Medication for cholesterol, blood pressure or diabetes	2.5	4.1	6.2	2.5	1.5
Diastolic blood pressure, automated reading	2.5	7.6	12.3	3.5	-1.7
Medication: Atenolol	2.4	3.0	5.9	0.3	-2.4
Noisy workplace	2.4	3.0	3.3	-1.8	-1.6
Number of full brothers	2.3	2.9	5.2	2.3	0.7
Medication: Aspirin	2.3	3.0	5.9	-2.4	-0.5
Relative age of first facial hair	2.2	4.6	8.6	-2.9	-0.7
Pulse wave Arterial Stiffness index	2.2	2.5	5.0	0.1	2.2
Exposure to tobacco smoke outside home	2.2	2.9	5.8	-0.1	2.4
Cholesterol lowering medication	2.2	3.2	3.5	-1.9	-1.7
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	4.5	-2.1	0.3
Forced vital capacity (FVC)	2.1	8.2	9.4	2.6	3.1
Heart attack	2.1	2.6	4.3	-2.1	-1.0
Pulse wave peak to peak time	2.1	2.5	4.9	-0.0	-2.2
Angina (self-reported)	2.1	2.8	5.2	-2.3	-0.7
Medication: Lisinopril	2.1	2.8	4.8	-2.2	-0.8
Reaction Time	2.0	3.9	7.7	2.8	-0.2
Falls in the last year	2.0	2.7	3.4	-1.8	-1.4
Pain type(s) experienced in last month: Hip pain	2.0	2.5	3.1	1.4	1.8
Medication: Atorvastatin	2.0	2.5	4.3	-2.1	0.9
Myopia	2.0	3.0	5.1	0.9	2.3
Heart attack/myocardial infarction (self-reported)	2.0	2.6	4.5	-2.1	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.8	4.5	-2.1	1.1
Handedness (chirality/laterality): Left-handed	1.9	2.3	4.2	-0.6	-2.0
Depression (self-reported)	1.8	2.2	4.2	0.3	2.1
Ever highly irritable/argumentative for 2 days	1.8	2.2	3.3	1.8	1.0
Worry too long after embarrassment	1.8	3.1	6.1	-2.5	-0.0
Medication: Blood pressure	1.8	3.1	3.4	-1.7	-1.8
Ever had bowel cancer screening	1.8	2.1	3.8	-0.7	-1.9
Medication: Blood pressure	1.8	3.3	6.6	-0.2	-2.6
Vascular/heart problems diagnosed by doctor	1.8	4.8	7.4	1.5	2.7
Hair/balding pattern: Pattern 3	1.7	2.5	2.9	1.5	1.7
Headache pain in last month	1.7	2.9	4.2	1.2	2.0
Illnesses of mother	1.6	2.0	3.5	1.9	0.7
Forced vital capacity (FVC), Best measure	1.6	6.0	7.6	2.1	2.8
Qualifications: nursing, teaching	1.6	2.6	3.7	-1.9	1.2
Illnesses of father: None of the above (group 1)	1.6	2.0	3.9	2.0	-0.3
Commuting to job workplace: Public transport	1.6	1.9	2.7	1.6	1.0
Systolic Blood Pressure	1.5	7.6	10.3	-3.2	-2.2
Forced expiratory volume in 1-second (FEV1)	1.5	4.9	6.7	1.7	2.6
Length of working week for main job	1.5	1.7	2.0	-1.4	1.2
Peak expiratory flow (PEF)	1.5	3.5	5.5	1.2	2.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	2.3	1.5	-1.2
Waist Hip Ratio (WHR)	1.4	6.3	11.0	-1.3	-3.3
Serious illness, injury or assault to yourself	1.4	1.8	3.5	-1.9	0.2
Chronic bronchitis/emphysema (father)	1.4	1.7	2.9	-1.7	0.7
Hair/balding pattern: Pattern 4	1.4	3.4	5.3	-2.3	-1.3
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	4.4	0.5	2.1
Health satisfaction	1.4	1.9	3.8	-0.1	1.9
Emphysema/chronic bronchitis	1.4	1.5	3.0	-0.2	1.7
Had major operations	1.4	1.6	2.1	-1.4	1.1
Hypertension (Self-reported)	1.4	3.8	6.7	-1.0	-2.6
Medication for cholesterol	1.4	2.1	4.2	-0.0	2.0
Guilty feelings	1.4	2.1	3.8	-2.0	-0.7
High cholesterol (Self-reported)	1.4	2.5	4.1	-2.0	-0.9
Commuting to job workplace: Cycle	1.4	1.7	3.3	0.2	-1.8
Qualifications: CSEs or equivalent	1.3	1.7	1.8	1.3	-1.3
Qualifications: None of the above	1.3	2.8	4.6	1.0	-2.1
Medication: Ramipril	1.3	1.6	3.1	0.4	-1.8
Mean time to correctly identify matches	1.3	2.5	3.9	2.0	-1.0
Supplements: Calcium	1.3	1.5	2.9	0.1	1.7
Severe depression (siblings)	1.2	1.4	1.7	1.0	1.3
High blood pressure	1.2	3.3	6.1	-0.7	-2.5
Nervous feelings	1.2	2.2	2.6	-1.6	-1.3
Had menopause	1.2	1.5	3.0	-0.3	-1.7
Hip circumference	1.2	5.2	10.3	3.2	0.0
Medication: Allopurinol	1.2	1.6	2.0	-1.4	-1.1
Overall health rating	1.2	2.7	5.2	0.3	2.3
Illnesses of father: High blood pressure	1.2	1.5	2.6	-1.6	0.7
Alzheimer’s Disease (in father)	1.1	1.2	2.1	-0.5	1.5
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.2	-0.5	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.7	1.0	1.6
Qualifications: A levels/AS levels or equivalent	1.1	2.4	3.6	-1.1	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.9	0.9	-1.4
Friendships satisfaction	1.1	1.3	1.8	1.3	0.9
Medication: Bendroflumethiazide	1.1	1.6	3.3	0.1	-1.8
Schizophrenia (2018)	1.0	2.1	4.1	-0.5	2.0
Alzheimer’s Disease (including proxy)	1.0	1.5	2.3	-1.5	0.8
Ulcerative Colitis	1.0	1.5	3.0	-0.1	1.7
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.2	-1.5	-0.6
Breastfed as a baby	1.0	1.3	2.3	0.5	-1.5
High blood pressure (siblings)	1.0	1.4	2.7	1.6	-0.4
Medication for pain relief, constipation, heartburn	1.0	1.8	2.4	-1.5	-1.1
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.2	-1.0	-1.1
Long-standing illness, disability or infirmity	1.0	1.5	3.1	-1.8	-0.0
Eye problems/disorders: Cataract	1.0	1.2	1.8	0.7	1.3
Wears glasses or contact lenses	1.0	1.2	1.7	1.3	-0.8
Intelligence (Savage-Jansen 2018)	0.9	2.7	5.2	2.3	0.3
Irritable Bowel Disease (IBD)	0.9	2.1	3.3	1.0	1.8
Rheumatoid Arthritis	0.9	1.3	1.4	-1.2	1.0
Heel T-Score	0.9	7.1	12.2	-1.4	-3.5
Fed-up feelings	0.9	1.6	1.8	1.4	1.2
Impedance of leg (left)	0.9	4.3	7.0	-2.6	-1.3
Mouth/teeth dental problems	0.9	1.4	2.0	0.8	-1.4
Happiness	0.9	1.1	1.4	0.9	1.2
Gout (self-reported)	0.9	1.3	1.5	-1.2	-1.1
Shortness of breath walking on level ground	0.9	1.0	1.8	0.4	1.4
Medication: Omeprazole	0.9	1.1	2.2	1.5	-0.2
Osteoarthritis (self-reported)	0.9	1.1	2.2	1.5	0.0
Smoking status: Current	0.9	1.5	2.9	-0.3	1.7
Ever taken oral contraceptive pill	0.9	1.0	2.0	0.1	1.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.7	1.3	0.7
Pain experienced in last month	0.9	1.5	2.8	-0.5	-1.7
Systolic blood pressure, automated reading	0.8	2.3	2.7	-1.6	-1.4
Impedance of leg (right)	0.8	4.0	6.2	-2.5	-1.3
Current tobacco smoking	0.8	1.3	2.5	-0.4	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.0	-0.7	-1.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.1	1.0	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	3.5	1.2	1.9
Tense / ‘highly strung’	0.8	1.3	2.3	-1.5	-0.6
Leg pain on walking	0.8	1.1	2.0	0.4	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.0	-1.4	-0.2
Knee pain experienced in last month	0.8	1.2	1.5	-1.2	1.0
Miserableness	0.8	1.4	2.8	0.3	1.7
Body Mass Index (BMI) (2010)	0.7	0.9	1.0	1.0	-1.0
LDL Cholesterol	0.7	1.1	1.8	-1.3	0.6
Medication: Co-codamol	0.7	0.8	1.6	-0.2	1.3
Leg fat-free mass (left)	0.7	3.7	6.2	2.5	1.1
Medication: Levothyroxine sodium	0.7	1.2	2.3	1.5	0.4
Leg predicted mass (left)	0.7	3.6	6.2	2.5	1.0
Time employed in main current job	0.7	0.8	1.3	-0.5	-1.2
Medication: Amlodipine	0.7	1.0	1.9	-1.4	-0.4
Age at last live birth	0.7	0.9	1.1	-0.9	1.0
Leg fat-free mass (right)	0.7	3.8	6.1	2.5	1.2
Mood swings	0.7	1.3	2.5	0.3	1.6
Leg predicted mass (right)	0.7	3.7	5.9	2.4	1.2
Mother’s age at death	0.7	0.9	1.6	-1.3	-0.4
Bipolar Disorder (2018)	0.6	0.9	1.4	-1.2	-0.7
Crohns Disease (2017)	0.6	1.3	1.6	1.0	1.3
Ulcerative Colitis (UC)	0.6	1.2	2.1	0.6	1.4
Crohns Disease (2012)	0.6	0.9	1.0	0.9	1.0
Hand grip strength (left)	0.6	1.7	1.9	-1.4	-1.2
Average weekly spirits intake	0.6	0.8	1.4	0.3	-1.2
Waist circumference	0.6	2.3	2.8	1.7	-1.3
Had other major operations	0.6	0.7	1.0	1.0	0.6
Financial difficulties in last 2 years	0.6	0.8	0.9	-0.8	1.0
Fluid intelligence score	0.6	1.3	1.3	1.1	1.1
Illnesses of siblings	0.6	0.8	1.6	-1.3	-0.1
Father’s age at death	0.6	0.8	1.5	1.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.0	-0.6	1.0
Exposure to tobacco smoke at home	0.6	0.6	1.3	-1.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.5	-1.2	0.4
Number of children fathered	0.6	0.6	1.1	-1.1	0.4
Age at first live birth	0.6	1.0	1.8	-1.4	0.4
Qualifications: College or University degree	0.6	1.8	3.6	0.2	1.9
Arm fat percentage (left)	0.6	2.4	4.5	2.1	-0.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.1	1.1	-0.5
Irritability	0.6	1.0	1.4	-0.7	-1.2
Risk taking	0.6	0.9	1.8	-1.4	0.1
Bipolar Disorder or Schizophrenia	0.5	1.2	1.2	-1.1	1.1
Alzheimer’s Disease (in mother)	0.5	0.5	1.1	-1.0	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.2	1.5	-0.3
Primary Biliary Cirrhosis	0.5	0.7	1.2	-0.4	1.1
Schizophrenia (2014)	0.5	1.0	1.8	-0.5	1.3
Hypothyroidism (self reported)	0.5	1.1	2.1	1.4	0.2
Trunk fat percentage	0.5	2.0	2.8	1.7	-1.1
Trunk fat mass	0.5	2.1	3.3	1.8	-0.9
Alcohol usually taken with meals	0.5	0.8	1.3	1.1	0.5
Arm fat percentage (right)	0.5	1.9	3.5	1.9	-0.5
Number of live births	0.5	0.7	0.7	0.8	0.8
Medication: Lansoprazole	0.5	0.5	0.6	-0.7	-0.8
Lung cancer (father)	0.5	0.6	1.1	1.1	-0.1
Arm fat mass (right)	0.5	2.1	4.1	2.0	-0.3
Pulse wave reflection index	0.5	0.6	1.1	-1.0	0.3
Loud music exposure frequency	0.5	0.5	1.0	-1.0	0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	-0.1	1.1
Body fat percentage	0.5	2.1	2.7	1.6	-1.2
Wheeze or whistling in the chest in last year	0.5	0.9	1.2	-1.1	0.7
Heart disease (mother)	0.5	0.6	1.1	-1.0	-0.4
Suffer from ‘nerves’	0.5	0.8	1.0	1.0	-0.7
Arm fat mass (left)	0.5	1.9	3.6	1.9	-0.3
Financial situation satisfaction	0.5	0.6	0.8	0.6	0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.4	-1.0
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	0.4	1.2
Age at First Birth	0.4	0.6	1.0	0.6	1.0
Respiratory disease	0.4	0.8	1.5	-0.3	1.2
Chronotype (morning person)	0.4	1.0	1.8	-0.4	-1.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	0.2	1.0
Vitamin and mineral supplements	0.4	0.5	0.9	1.0	-0.3
Hand grip strength (right)	0.4	1.1	2.2	-1.5	0.1
Townsend deprivation index at recruitment	0.4	0.6	0.6	0.7	0.8
Relative age voice broke	0.4	0.5	1.0	-0.3	-1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.7	-0.9	0.3
Stomach or abdominal pain in last month	0.4	0.4	0.9	-0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	-0.9	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.6	0.1	-1.3
Weight	0.4	1.8	3.7	1.9	-0.2
Birth weight of first child	0.4	0.8	1.4	-1.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.6	1.3	0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	-1.0	0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	-0.4	0.9
Leg fat percentage (right)	0.4	1.3	1.8	0.9	-1.3
Whole body fat mass	0.4	1.8	3.2	1.8	-0.7
Comparative height size at age 10	0.4	2.1	2.4	1.3	1.6
Illnesses of father: Heart disease	0.4	0.6	1.2	-1.1	-0.1
Number of self-reported non-cancer illnesses	0.4	0.7	0.9	-1.0	-0.7
Ever smoked	0.4	0.7	1.2	-0.5	1.1
Basal metabolic rate	0.4	2.1	3.5	1.9	0.8
Leg fat percentage (left)	0.4	1.4	1.7	1.0	-1.3
Number of operations (self-reported)	0.4	0.6	0.9	-0.4	1.0
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.9	0.3
Coronary Artery Disease (CAD)	0.3	0.4	0.5	0.7	0.5
Triglycerides	0.3	0.5	1.0	1.0	-0.2
Blood Eosinophil Count	0.3	2.2	3.7	-1.9	0.9
Neuroticism	0.3	0.8	0.9	-0.9	0.8
Sensitivity / hurt feelings	0.3	0.5	0.8	-0.9	-0.4
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.6	0.6	0.8
Medication for hormone replacement therapy	0.3	0.4	0.7	-0.3	0.8
Maternal smoking around birth	0.3	0.4	0.6	-0.8	-0.4
Body mass index (BMI)	0.3	1.3	2.6	1.6	-0.3
Hair/balding pattern: Pattern 2	0.3	0.3	0.5	-0.4	-0.7
Prospective memory result	0.3	0.4	0.7	-0.2	0.8
Glaucoma (self-reported)	0.3	0.3	0.4	0.5	-0.6
Birth weight	0.3	0.7	1.2	-1.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.8	0.0
Leg fat mass (right)	0.3	1.1	1.4	1.2	-0.9
Alcohol intake frequency.	0.3	0.6	0.8	0.7	-0.9
Whole body fat-free mass	0.3	2.0	3.1	1.8	1.0
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.5	-0.5	-0.7
Whole body water mass	0.3	1.9	2.9	1.7	1.0
Hearing aid user	0.3	0.3	0.3	-0.5	-0.6
Average weekly beer plus cider intake	0.3	0.4	0.5	-0.5	0.7
Leg fat mass (left)	0.3	1.2	1.6	1.2	-0.9
Neuroticism (Nagel 2018)	0.2	0.5	1.0	-1.0	-0.0
Ovarian Cancer	0.2	0.3	0.6	-0.3	0.8
Fasting Glucose	0.2	0.3	0.5	-0.7	0.0
HDL Cholesterol	0.2	0.3	0.4	0.6	0.3
Blood Platelet Count	0.2	2.3	4.6	2.1	0.3
Blood Red Count	0.2	1.9	2.9	1.7	-1.0
Blood White Count	0.2	1.6	2.7	1.6	0.7
Cardiovascular Disease	0.2	0.8	1.5	-0.2	-1.2
Number of treatments/medications taken	0.2	0.3	0.4	-0.7	-0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.6	-0.1
Age when periods started (menarche)	0.2	0.5	1.0	-1.0	-0.3
High blood pressure (mother)	0.2	0.2	0.2	-0.5	-0.5
Number of incorrect matches in round	0.2	0.3	0.4	-0.7	-0.4
Trunk fat-free mass	0.2	1.2	1.5	1.2	1.0
Trunk predicted mass	0.2	1.2	1.7	1.3	0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	0.1	0.6
Chest pain or discomfort	0.2	0.3	0.5	-0.1	0.7
Smoking status: Previous	0.2	0.3	0.3	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.5	0.5	0.7
Loneliness, isolation	0.2	0.3	0.6	0.8	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.4	0.3	0.7
Mineral and other dietary supplements	0.2	0.3	0.5	-0.7	-0.2
Asthma (self-reported)	0.2	0.4	0.5	-0.7	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.6	0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.4	0.6
Pack years of smoking	0.2	0.3	0.5	-0.0	-0.7
Impedance of whole body	0.2	1.2	1.7	-1.3	-0.8
Worry (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.4
Major Depression (MDD)	0.1	0.1	0.1	0.1	0.4
Bipolar Disorder (2011)	0.1	0.1	0.1	0.0	0.4
Mean Putamen Volume	0.1	0.1	0.1	-0.2	-0.4
Lupus	0.1	0.1	0.2	-0.2	-0.4
BMI	0.1	0.3	0.7	0.2	-0.8
Height	0.1	2.0	2.9	1.1	-1.7
Allergy or Eczema	0.1	0.2	0.4	-0.6	-0.2
Tanning	0.1	1.4	2.0	1.4	-0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.1	-0.4
Pack years adult smoking proportion	0.1	0.1	0.2	0.1	-0.4
Average weekly fortified wine intake	0.1	0.1	0.1	0.3	-0.4
Taking other prescription medications	0.1	0.1	0.1	-0.3	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.1	-0.7
Multivitamins +/- minerals	0.1	0.1	0.2	-0.1	0.4
Supplements: Glucosamine	0.1	0.1	0.3	-0.1	0.5
Past tobacco smoking	0.1	0.1	0.2	0.5	-0.1
Neuroticism score	0.1	0.2	0.5	-0.7	-0.0
Worrier / anxious feelings	0.1	0.2	0.3	-0.2	0.5
Mouth/teeth dental problems: Dentures	0.1	0.3	0.5	-0.7	0.1
Asthma	0.1	0.3	0.3	-0.5	0.5
Arm fat-free mass (right)	0.1	0.8	1.5	1.2	0.2
Comparative body size at age 10	0.1	0.2	0.5	0.0	-0.7
Neck or shoulder pain in last month	0.1	0.1	0.1	-0.4	0.4
Arm predicted mass (right)	0.1	0.6	1.1	1.1	0.1
Average weekly red wine intake	0.1	0.1	0.1	-0.3	-0.2
Back pain experienced in last month	0.1	0.2	0.3	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.3	-0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	0.4
Arm fat-free mass (left)	0.1	0.7	1.2	1.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.1
Heart disease (siblings)	0.1	0.1	0.2	-0.5	0.1
Arm predicted mass (left)	0.1	0.6	1.2	1.1	0.1
Depression (Nagel 2018)	0.0	0.0	0.0	-0.1	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.0	0.0	0.0
Smoking Status	0.0	0.1	0.1	-0.4	0.3
Hair Pigment	0.0	1.3	2.6	-1.6	0.4
Supplements: Zinc	0.0	0.0	0.1	0.0	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.1	0.1
Sitting height	0.0	0.2	0.2	0.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	0.2	0.0
Allergy	0.0	0.1	0.2	-0.1	0.4
Impedance of arm (right)	0.0	0.1	0.2	-0.5	0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.3	-0.1
Impedance of arm (left)	0.0	0.0	0.0	-0.2	-0.1
Standing height	0.0	0.3	0.5	0.7	0.4
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.3	0.0
Eye problems/disorders: None of the above	0.0	0.0	0.0	-0.1	-0.1
Migraine (self-reported)	0.0	0.0	0.1	-0.3	0.0
Number of full sisters	0.0	0.0	0.0	0.1	-0.0
Family relationship satisfaction	0.0	0.0	0.0	0.1	-0.1
Supplements: Vitamin C	0.0	0.0	0.1	0.3	-0.1
Breast cancer (self-reported)	0.0	0.0	0.1	-0.3	0.0
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.2	-0.0
Alcohol drinker status: Previous	0.0	0.0	0.0	-0.1	0.0

Hub : Genes

KLHL42

Models

Trait associations