TWAS hub - KLHDC5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0198	0.0097	0.00240	-0.001	0.010	0.009	NA	0.001	0.92000	0.0032	0.0055	NA	0.160
2	TCGA	Stomach Adenocarcinoma	0.0560	0.0260	0.00049	0.045	0.025	0.019	NA	0.017	0.00033	0.0063	0.0140	NA	0.019

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Diabetes diagnosed by doctor	10.2	16.8	23.7	3.1	4.9
Diabetes (self-reported)	10.0	15.4	24.2	2.6	4.9
Type 2 Diabetes (T2D) (2018)	8.3	15.6	16.5	4.1	3.8
Type 2 Diabetes (T2D) (2012)	8.1	9.3	15.3	1.8	3.9
Medication: Gliclazide	7.4	8.4	12.0	3.5	2.2
Pulse rate, automated reading	6.4	20.8	30.7	-3.3	-5.5
Diabetes (father)	6.2	7.7	10.7	2.1	3.3
Ever depressed for a whole week	5.6	6.9	7.6	2.5	2.7
Lung FEV1/FVC ratio	5.4	27.6	43.4	3.4	6.6
Medication: Metformin	5.2	7.3	8.2	2.5	2.9
Medication: Ibuprofen (e.g. Nurofen)	4.9	6.3	9.3	-1.8	-3.0
Medication: Ibuprofen	4.9	5.9	9.1	-1.6	-3.0
Medication: Paracetamol	4.8	7.9	9.9	-2.4	-3.2
Illnesses of siblings: Diabetes	4.8	5.9	6.4	2.3	2.5
HbA1C	4.5	5.0	5.0	2.2	2.2
Hair/balding pattern: Pattern 3	4.5	6.7	13.4	-3.7	-0.3
Handedness (chirality/laterality): Left-handed	4.5	5.4	10.8	3.3	0.2
Tinnitus: Yes, now most or all of the time	4.4	5.2	6.3	2.5	2.0
Noisy workplace	4.3	5.3	8.4	2.9	1.4
Reason for reducing amount of alcohol drunk: Health precaution	4.1	4.8	5.6	2.4	2.0
Medication: Paracetamol	4.1	6.3	9.5	-1.8	-3.1
Medication: Simvastatin	3.9	5.8	7.8	1.9	2.8
Hearing difficulty/problems with background noise	3.6	5.8	6.7	2.2	2.6
Diabetes (mother)	3.5	4.4	5.0	2.2	2.0
Medication: Cholesterol lowering	3.4	5.3	5.5	2.3	2.3
Medication for cholesterol, blood pressure or diabetes	3.4	5.7	6.6	-2.6	-2.2
Hearing difficulty/problems: Yes	3.3	5.0	9.1	0.9	3.0
Medication: Seretide 50 evohaler	3.3	3.9	7.5	0.5	2.7
Reaction Time	3.2	6.1	10.0	-1.5	-3.2
Pulse rate	3.2	5.5	10.0	-1.0	-3.2
Heart attack/myocardial infarction (self-reported)	3.1	4.0	4.0	2.0	2.0
Sensitivity / hurt feelings	3.0	5.2	10.3	3.2	0.2
Heart attack	3.0	3.8	4.0	2.0	1.9
Ever highly irritable/argumentative for 2 days	3.0	3.6	7.1	0.4	-2.7
Medication: Aspirin	3.0	3.9	4.8	1.7	2.2
Number of full brothers	2.9	3.7	7.2	0.4	-2.7
Relative age of first facial hair	2.8	5.7	11.3	0.4	3.4
Had other major operations	2.7	3.3	4.3	-2.1	-1.5
Friendships satisfaction	2.6	3.2	4.6	-1.3	-2.1
Ever unenthusiastic/disinterested for a whole week	2.5	3.1	5.2	2.3	1.0
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	4.6	2.1	1.2
Commuting to job workplace: Public transport	2.5	2.9	3.4	-1.8	-1.6
Exposure to tobacco smoke outside home	2.4	3.2	6.4	-2.5	-0.0
Falls in the last year	2.3	3.1	4.8	1.2	2.2
Medication: Aspirin	2.2	2.9	4.7	1.0	2.2
Illnesses of mother	2.1	2.6	3.8	-1.9	-1.2
Worry too long after embarrassment	2.1	3.5	4.3	2.1	1.6
Alcohol drinker status: Never	2.1	2.5	2.9	1.7	1.5
Hair/balding pattern: Pattern 2	2.0	2.5	5.0	2.2	-0.3
Length of working week for main job	2.0	2.2	3.8	-0.8	2.0
Medication: Allopurinol	2.0	2.6	3.1	1.8	1.5
Hair/balding pattern: Pattern 4	1.9	4.6	5.4	-1.9	2.3
Cholesterol lowering medication	1.9	2.8	4.6	1.0	2.1
Angina	1.8	2.4	3.7	1.0	1.9
Mean time to correctly identify matches	1.8	3.4	5.5	-1.1	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	4.2	1.0	2.0
Illnesses of father: High blood pressure	1.7	2.1	2.2	1.5	1.4
Lung FVC	1.6	8.4	8.6	2.9	-2.9
Pain all over the body in last month	1.6	1.7	3.4	1.8	0.2
Headache pain in last month	1.6	2.7	3.0	-1.7	-1.6
Gout (self-reported)	1.6	2.2	2.8	1.2	1.7
Medication for pain relief, constipation, heartburn	1.6	2.8	4.0	1.3	2.0
Qualifications: nursing, teaching	1.6	2.4	4.3	-0.8	2.1
Eye problems/disorders: Cataract	1.6	1.9	3.8	0.0	-1.9
High cholesterol (Self-reported)	1.6	2.9	3.7	1.4	1.9
Medication: Atorvastatin	1.6	1.9	3.3	0.7	1.8
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	3.2	-0.8	-1.8
Medication: Blood pressure	1.5	2.7	3.5	1.4	1.9
Angina (self-reported)	1.5	2.0	3.2	0.8	1.8
Illnesses of father: Heart disease	1.5	2.1	3.7	1.9	0.7
Diastolic blood pressure, automated reading	1.5	4.6	7.2	-2.7	-1.4
Systolic Blood Pressure	1.4	7.0	10.2	2.0	3.2
Nervous feelings	1.4	2.6	3.5	1.3	1.9
Hip circumference	1.4	6.2	12.1	-0.6	-3.5
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.1	1.8	0.4
Number of children fathered	1.4	1.6	2.0	1.4	1.0
Medication: Omeprazole	1.4	1.6	2.8	-0.6	-1.7
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.5	0.3	-1.9
Ever had hysterectomy (womb removed)	1.3	1.4	2.9	-1.7	-0.0
Alcohol intake versus 10 years previously	1.3	2.0	3.9	2.0	-0.0
Had major operations	1.3	1.5	2.7	0.6	1.6
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.9	-0.5	-1.7
Hypothyroidism (self reported)	1.2	2.8	5.7	-2.4	-0.0
Forced vital capacity (FVC)	1.2	4.5	8.6	0.5	-2.9
Comparative height size at age 10	1.2	6.7	6.9	-2.5	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	1.9	1.4	-1.0
Leg fat-free mass (right)	1.2	6.3	6.7	-2.4	-2.6
Long-standing illness, disability or infirmity	1.2	1.8	2.9	0.9	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.7	-1.3	0.9
Leg predicted mass (right)	1.2	6.4	6.6	-2.5	-2.6
Number of operations (self-reported)	1.2	1.8	3.7	-1.9	0.2
Risk taking	1.2	1.7	2.2	1.5	1.1
Age started oral contraceptive pill	1.2	1.5	2.3	0.9	1.5
Leg fat-free mass (left)	1.1	5.9	7.3	-2.1	-2.7
Leg predicted mass (left)	1.1	5.9	7.1	-2.1	-2.7
Tense / ‘highly strung’	1.1	1.8	2.7	0.9	1.7
Guilty feelings	1.1	1.6	2.8	0.7	1.7
Mother’s age at death	1.1	1.4	1.6	1.3	1.1
Medication: Lisinopril	1.1	1.4	2.1	0.9	1.4
Irritability	1.1	1.9	3.0	1.7	0.9
LDL Cholesterol	1.0	1.5	2.0	1.0	1.4
Systolic blood pressure, automated reading	1.0	2.9	5.3	0.6	2.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.2	1.1	1.1
Serious illness, injury or assault to yourself	1.0	1.2	2.1	0.5	1.5
Impedance of leg (left)	1.0	4.7	6.3	1.8	2.5
Loneliness, isolation	1.0	1.3	2.2	-1.5	-0.7
Wears glasses or contact lenses	1.0	1.2	2.4	-1.6	0.0
Medication: Lansoprazole	0.9	1.0	1.6	1.3	0.7
Pulse wave reflection index	0.9	1.1	1.9	1.4	0.4
Medication: Amlodipine	0.9	1.2	2.3	0.4	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.0	-0.2	1.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.4	-0.8	1.2
Whole body fat-free mass	0.9	5.1	6.0	-2.4	-2.1
Commuting to job workplace: Walk	0.9	0.9	1.9	1.4	-0.0
Illnesses of father: None of the above (group 1)	0.9	1.1	1.5	-1.2	-0.8
Whole body water mass	0.9	4.9	5.8	-2.4	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.1	-1.4	0.4
Intelligence (Savage-Jansen 2018)	0.8	2.5	4.2	-0.9	-2.0
Medication for hormone replacement therapy	0.8	0.8	1.0	0.8	1.0
Impedance of leg (right)	0.8	4.1	4.7	1.9	2.2
Fed-up feelings	0.8	1.4	2.1	-1.4	-0.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.4	-0.6	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.4	-1.5	-0.4
Lung cancer (father)	0.8	1.0	1.6	-0.6	-1.3
Exposure to tobacco smoke at home	0.8	0.9	1.8	0.1	1.4
Loud music exposure frequency	0.8	0.8	1.3	-0.6	1.2
Forced vital capacity (FVC), Best measure	0.8	3.0	5.9	0.2	-2.4
Arm fat-free mass (right)	0.8	4.0	5.7	-2.4	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.7	1.3	0.6
Age at first live birth	0.8	1.5	2.4	1.6	0.8
Family relationship satisfaction	0.8	0.9	1.8	-0.2	-1.4
Basal metabolic rate	0.8	4.4	4.5	-2.1	-2.1
Vascular/heart problems diagnosed by doctor	0.8	2.1	2.2	-1.4	-1.5
Heart disease (siblings)	0.8	1.0	2.0	1.4	0.2
Bipolar Disorder (2018)	0.7	1.2	1.7	1.3	0.8
Schizophrenia vs Biploar Disorder	0.7	1.0	1.4	0.7	1.2
Rheumatoid Arthritis	0.7	1.0	2.0	-0.1	1.4
Vitamin and mineral supplements	0.7	0.9	1.0	-1.0	-1.0
Severe depression (siblings)	0.7	0.8	1.5	-0.2	-1.2
Pack years adult smoking proportion	0.7	1.1	1.5	1.2	-0.8
Age when periods started (menarche)	0.7	1.7	1.8	1.3	1.3
Sitting height	0.7	5.0	8.4	-2.9	-1.2
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.6	-0.4	-1.3
Fluid intelligence score	0.7	1.4	1.6	-1.3	-1.1
Arm fat percentage (right)	0.7	2.6	3.3	1.4	-1.8
Standing height	0.7	7.0	11.5	-3.4	-1.6
Blood clot in the leg (DVT)	0.7	0.9	1.6	-1.3	0.5
Health satisfaction	0.7	0.9	1.1	1.0	-0.9
Arm predicted mass (right)	0.7	3.4	5.0	-2.2	-1.4
Alcohol intake frequency.	0.7	1.6	2.8	0.6	-1.7
Age at last live birth	0.7	1.0	1.5	1.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.0	-1.4	-1.0
Back pain experienced in last month	0.7	1.1	1.8	-0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.8	1.7	0.3
Eye problems/disorders: Glaucoma	0.7	0.8	1.4	-1.2	-0.5
Myopia	0.7	1.0	1.2	-1.1	-0.9
Height	0.6	11.0	17.0	-4.1	-2.2
Maternal smoking around birth	0.6	0.8	1.6	-0.3	1.3
Medication: Levothyroxine sodium	0.6	1.0	1.2	-1.1	-0.9
High blood pressure (mother)	0.6	0.8	1.3	1.1	0.6
Trunk fat-free mass	0.6	3.7	4.9	-2.2	-1.6
Happiness	0.6	0.8	1.6	-0.1	-1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.4	-0.7	1.6
Trunk predicted mass	0.6	3.6	4.6	-2.2	-1.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.3	-1.5	-0.3
Shortness of breath walking on level ground	0.6	0.7	0.9	-1.0	-0.6
Migraine (self-reported)	0.6	0.7	1.0	-1.0	0.6
Leg pain on walking	0.6	0.7	1.3	0.4	-1.1
Hypertension (Self-reported)	0.6	1.5	2.0	1.4	1.1
Arm fat percentage (left)	0.6	2.5	4.0	1.0	-2.0
Arm fat-free mass (left)	0.6	3.3	4.8	-2.2	-1.3
Alcohol drinker status: Previous	0.6	0.7	0.8	0.7	-0.9
Arm predicted mass (left)	0.6	3.0	4.2	-2.0	-1.3
Depressed Affect (Nagel 2018)	0.5	1.0	1.6	-1.3	-0.5
Alzheimer’s Disease (including proxy)	0.5	0.7	1.1	1.0	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.2	-0.3	-1.5
Triglycerides	0.5	0.8	1.5	0.3	-1.2
Blood Red Count	0.5	4.6	5.8	-1.9	-2.4
Heel T-Score	0.5	3.8	6.2	2.5	1.2
Hand grip strength (right)	0.5	1.3	2.7	-0.2	1.6
Qualifications: CSEs or equivalent	0.5	0.7	1.4	0.0	-1.2
Waist circumference	0.5	1.7	3.4	0.1	-1.8
Mouth/teeth dental problems	0.5	0.8	1.1	-0.8	-1.0
Neuroticism score	0.5	1.1	1.9	1.4	0.5
Weight	0.5	2.4	3.8	-1.0	-1.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.1	1.0	-1.5
Arm fat mass (right)	0.5	2.1	4.0	0.3	-2.0
Heart disease (mother)	0.5	0.6	1.1	1.1	0.2
Number of full sisters	0.5	0.6	1.2	1.1	-0.3
Knee pain experienced in last month	0.5	0.7	1.4	0.1	1.2
Arm fat mass (left)	0.5	2.0	4.0	0.1	-2.0
Ever smoked	0.5	0.9	1.7	1.3	0.1
Commuting to job workplace: Cycle	0.5	0.6	1.0	1.0	0.3
Pack years of smoking	0.5	0.8	1.3	1.1	-0.5
Bipolar Disorder or Schizophrenia	0.4	1.0	1.5	1.2	0.7
Blood Platelet Count	0.4	4.5	5.4	-2.3	-1.9
Waist Hip Ratio (WHR)	0.4	1.7	3.0	-0.7	1.7
Allergy or Eczema	0.4	1.1	1.6	1.3	0.8
Cardiovascular Disease	0.4	1.2	2.5	1.6	-0.1
Respiratory disease	0.4	0.8	1.6	-1.3	-0.0
Hand grip strength (left)	0.4	1.0	1.9	-0.1	1.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.5	-0.7	-0.6
Townsend deprivation index at recruitment	0.4	0.5	1.0	-0.3	-1.0
Taking other prescription medications	0.4	0.6	1.1	-0.1	1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.6	-0.5	0.8
High blood pressure	0.4	1.1	1.2	1.1	1.0
Trunk fat mass	0.4	1.5	3.0	-0.2	-1.7
Illnesses of siblings	0.4	0.5	0.9	1.0	0.4
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	-0.2	-1.0
High blood pressure (siblings)	0.4	0.5	0.6	-0.8	-0.7
Leg fat percentage (right)	0.4	1.5	3.0	1.7	-0.2
Whole body fat mass	0.4	1.5	3.0	-0.1	-1.7
Mineral and other dietary supplements	0.4	0.5	0.5	0.7	0.7
Osteoarthritis (self-reported)	0.4	0.5	1.0	-0.3	-1.0
Number of self-reported non-cancer illnesses	0.4	0.8	1.4	0.3	1.2
Pain experienced in last month	0.4	0.6	0.9	0.9	0.7
Worry (Nagel 2018)	0.3	0.6	0.7	0.6	0.8
Age at First Birth	0.3	0.4	0.4	-0.6	-0.6
Lupus	0.3	0.5	0.9	0.3	0.9
Blood Eosinophil Count	0.3	2.7	3.8	1.3	1.9
Blood White Count	0.3	2.0	2.7	-1.2	-1.6
Chronotype (morning person)	0.3	0.6	1.1	1.0	0.4
Trunk fat percentage	0.3	1.1	2.2	0.3	-1.5
Relative age voice broke	0.3	0.4	0.6	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.9	1.0	0.5
Past tobacco smoking	0.3	0.6	0.8	-0.9	-0.6
Alcohol usually taken with meals	0.3	0.5	0.5	-0.7	-0.6
Financial difficulties in last 2 years	0.3	0.4	0.7	0.2	0.8
Impedance of arm (right)	0.3	1.6	3.1	1.8	0.0
Father’s age at death	0.3	0.4	0.8	-0.1	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	0.6	0.8	0.5
Birth weight of first child	0.3	0.6	1.0	1.0	0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	-0.3	0.9
Birth weight	0.3	0.7	1.0	0.6	1.0
Body fat percentage	0.3	1.2	1.9	0.7	-1.4
Pulse wave peak to peak time	0.3	0.4	0.7	0.1	0.8
Supplements: Vitamin C	0.3	0.3	0.6	-0.8	-0.2
Smoking status: Previous	0.3	0.4	0.5	0.6	0.7
Financial situation satisfaction	0.3	0.4	0.8	0.2	-0.9
Leg fat percentage (left)	0.3	1.0	2.0	1.4	-0.3
Fractured/broken bones in last 5 years	0.3	0.3	0.5	-0.7	-0.4
Unable to work because of sickness or disability	0.3	0.3	0.4	-0.5	0.7
Supplements: Calcium	0.3	0.4	0.7	0.8	-0.2
Impedance of whole body	0.3	1.3	1.7	1.3	1.0
Neuroticism (Nagel 2018)	0.2	0.6	0.8	0.6	0.9
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	0.7	0.0
Bipolar Disorder (2011)	0.2	0.1	0.3	-0.5	0.1
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.0	-0.7
Coronary Artery Disease (CAD)	0.2	0.3	0.4	-0.6	-0.4
Fasting Glucose	0.2	0.2	0.4	-0.6	0.3
HDL Cholesterol	0.2	0.3	0.5	-0.4	-0.7
Primary Biliary Cirrhosis	0.2	0.3	0.4	0.6	0.4
BMI	0.2	0.9	1.8	1.4	-0.2
Neuroticism	0.2	0.5	0.8	0.4	0.9
Tanning	0.2	2.3	4.4	-2.1	-0.5
Number of treatments/medications taken	0.2	0.3	0.3	-0.6	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	-0.6	-0.5
Supplements: Zinc	0.2	0.2	0.4	0.6	-0.2
Medication: Co-codamol	0.2	0.2	0.2	0.3	-0.5
Average weekly fortified wine intake	0.2	0.3	0.4	0.6	0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.7	0.9	-0.5
Multivitamins +/- minerals	0.2	0.2	0.2	0.4	0.5
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.1	0.7
Chronic bronchitis/emphysema (father)	0.2	0.3	0.4	-0.4	0.7
Body mass index (BMI)	0.2	1.0	1.7	0.5	-1.3
Number of incorrect matches in round	0.2	0.4	0.4	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	0.8	0.6	-0.9
Medication: Ramipril	0.2	0.2	0.4	0.7	0.0
Number of live births	0.2	0.3	0.5	0.4	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.7	0.8	-0.8
Impedance of arm (left)	0.2	0.9	1.6	1.3	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	-0.8	-0.4
Glaucoma (self-reported)	0.2	0.2	0.3	-0.5	0.4
Comparative body size at age 10	0.2	0.5	0.7	0.9	-0.5
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.1	0.9
Qualifications: College or University degree	0.2	0.5	0.8	-0.9	-0.6
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.4	0.5
Neck or shoulder pain in last month	0.2	0.4	0.4	-0.6	0.6
Leg fat mass (right)	0.2	0.8	0.9	0.8	-1.0
Average weekly red wine intake	0.2	0.3	0.5	0.2	0.7
Ever had bowel cancer screening	0.2	0.3	0.3	0.5	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	0.3	0.7
Asthma (self-reported)	0.2	0.3	0.7	-0.2	0.8
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.1	0.7
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.2	-0.5
Medication: Bendroflumethiazide	0.2	0.3	0.3	-0.4	0.6
Leg fat mass (left)	0.2	0.6	0.9	0.6	-1.0
Depression (Nagel 2018)	0.1	0.1	0.2	-0.4	0.1
Schizophrenia (2018)	0.1	0.2	0.3	0.5	0.3
Ulcerative Colitis (UC)	0.1	0.1	0.1	0.3	0.3
Major Depression (MDD)	0.1	0.1	0.1	-0.4	0.4
Neuroticism (2016)	0.1	0.2	0.2	-0.5	0.4
Schizophrenia (2014)	0.1	0.2	0.3	0.5	0.3
Ulcerative Colitis	0.1	0.1	0.2	0.4	0.2
Smoking Status	0.1	0.3	0.6	0.1	0.8
Hair Pigment	0.1	3.7	6.4	2.5	1.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.2	-0.5	-0.3
Current tobacco smoking	0.1	0.1	0.2	0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.5	0.2
Supplements: Glucosamine	0.1	0.1	0.1	-0.3	-0.3
Medication: Atenolol	0.1	0.1	0.1	0.4	-0.0
Had menopause	0.1	0.1	0.3	-0.5	0.1
Qualifications: None of the above	0.1	0.3	0.6	-0.2	-0.8
Time employed in main current job	0.1	0.2	0.3	0.6	0.1
Worrier / anxious feelings	0.1	0.1	0.3	-0.0	0.5
Asthma	0.1	0.2	0.3	-0.2	0.6
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.4	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.5	-0.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.4	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.0	0.5
Suffer from ‘nerves’	0.1	0.1	0.2	0.0	-0.5
Overall health rating	0.1	0.3	0.3	-0.4	-0.6
Chest pain or discomfort	0.1	0.1	0.3	0.5	0.1
Medication for cholesterol	0.1	0.2	0.2	-0.5	-0.5
Breast cancer (self-reported)	0.1	0.1	0.2	-0.4	0.2
Smoking status: Current	0.1	0.1	0.1	0.3	0.3
Miserableness	0.1	0.2	0.2	-0.5	-0.4
Medication: Blood pressure	0.1	0.1	0.2	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.4	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.2	-0.5
Alzheimer’s Disease (in father)	0.0	0.0	0.0	0.2	0.1
Crohns Disease (2017)	0.0	0.1	0.1	0.2	-0.3
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	0.3	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.0	0.0	0.1	-0.1	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.1	0.3	-0.3
Mean Putamen Volume	0.0	0.0	0.0	0.2	-0.2
Average weekly spirits intake	0.0	0.1	0.1	0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.1	-0.3
Allergy	0.0	0.1	0.2	-0.4	0.1
Depression (self-reported)	0.0	0.0	0.0	-0.1	0.2
Prospective memory result	0.0	0.0	0.0	0.1	-0.0
Breastfed as a baby	0.0	0.0	0.1	0.1	-0.3
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.2	-0.1
Mood swings	0.0	0.0	0.1	-0.3	0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	0.4	0.1
Average weekly champagne plus white wine intake	0.0	0.0	0.1	-0.2	0.1
Hearing aid user	0.0	0.0	0.0	0.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.1	0.1
Average weekly beer plus cider intake	0.0	0.1	0.1	-0.3	0.0

Hub : Genes

KLHDC5

Models

Trait associations