TWAS hub - ATP2A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0300	0.0180	7.8e-03	0.019	0.009	0.006	0.011	0.015	2.1e-03	0.0240	6.0e-02	0.014	4.9e-03
2	GTEx	Artery Tibial	0.1126	0.0473	3.0e-04	-0.003	NA	0.032	NA	0.003	9.0e-01	NA	1.4e-03	NA	1.9e-01
3	GTEx	Brain Caudate basal ganglia	0.1830	0.0870	3.9e-03	0.070	NA	0.040	NA	0.023	4.8e-03	NA	2.7e-02	NA	7.4e-02
4	GTEx	Esophagus Muscularis	0.1370	0.0480	2.6e-06	0.134	NA	0.104	NA	0.122	1.6e-08	NA	7.2e-07	NA	7.6e-08
5	NTR	Blood	0.0263	0.0146	6.5e-03	0.001	0.001	0.002	0.003	0.001	1.8e-01	0.1300	5.5e-02	0.038	1.2e-01
6	TCGA	Prostate Adenocarcinoma	0.0371	0.0214	3.7e-03	0.026	0.015	0.020	NA	0.028	8.0e-04	0.0084	3.5e-03	NA	6.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Headache pain in last month	8.3	14.3	31.7	-5.5	5.6	3.6	1.4	2.1	2.1
Pulse rate, automated reading	4.5	14.5	29.6	-2.1	0.7	2.6	-5.4	-4.3	5.2
Exposure to tobacco smoke outside home	4.3	5.7	10.1	-2.0	3.2	2.6	3.1	1.7	-0.8
Pack years of smoking	4.2	6.2	13.7	-1.7	3.6	1.1	2.3	3.7	-1.1
Medication: Paracetamol	4.0	6.6	16.6	-4.1	3.5	2.6	1.6	0.4	1.2
Emphysema/chronic bronchitis	4.0	4.5	12.2	-2.3	3.5	2.2	1.3	1.7	0.4
Tinnitus: Yes, but not now, but have in the past	3.8	4.1	8.1	1.3	-2.6	-2.8	-2.2	-1.4	1.2
Average weekly beer plus cider intake	3.7	5.4	11.1	-3.0	2.7	2.2	3.3	-0.1	-0.6
Medication for pain relief, constipation, heartburn	3.4	5.8	13.1	3.6	-3.5	-1.5	-1.7	-1.6	-1.0
Family relationship satisfaction	3.4	4.2	9.4	3.1	-1.1	-1.4	1.1	1.5	-3.0
Pack years adult smoking proportion	3.3	5.0	11.8	-1.5	3.4	1.0	2.2	3.0	-1.1
Number of live births	3.3	4.6	8.7	-2.5	3.0	1.4	2.4	2.0	-1.0
Noisy workplace	3.3	4.0	6.7	-0.6	2.2	0.3	2.4	2.6	-2.5
Age at First Birth	3.1	4.5	9.2	2.4	-3.0	-1.2	-2.7	-1.9	0.0
Body Mass Index (BMI) (2010)	3.0	4.2	13.8	0.4	1.7	-0.0	3.7	2.9	0.0
Neuroticism (2016)	2.9	4.1	9.8	-2.8	1.7	3.1	1.8	0.5	0.9
Diastolic blood pressure, automated reading	2.9	8.9	15.0	-0.3	-3.1	-2.0	-3.6	-3.9	3.4
Hypothyroidism/myxoedema (self-reported)	2.8	5.4	12.5	-3.5	1.9	1.8	1.6	2.9	1.5
Hypothyroidism (self reported)	2.6	5.9	13.4	-3.7	1.8	1.7	2.0	2.8	2.1
Medication: Paracetamol	2.6	4.0	10.3	-3.2	2.7	2.0	0.9	-0.2	1.1
Heart disease (siblings)	2.6	3.2	6.9	2.2	-2.0	-2.6	-1.6	-1.0	-0.2
Stomach or abdominal pain in last month	2.5	3.1	6.0	0.2	2.0	0.2	2.0	2.1	-2.4
Length of working week for main job	2.5	2.8	10.4	-0.5	-0.8	1.4	-0.9	-3.2	1.5
Leg pain on walking	2.5	3.1	6.0	-1.4	2.1	-0.6	2.4	2.2	-1.1
Leg fat mass (left)	2.5	9.7	25.3	-0.9	3.1	0.8	5.0	1.9	-4.3
Verbal and Numeric Reasoning (VNR)	2.4	5.7	18.8	4.3	-1.6	-2.4	-1.6	0.6	-1.9
Alcohol drinker status: Previous	2.4	2.8	6.8	-0.6	1.0	-2.6	-1.5	-0.3	2.4
Medication: Ventolin 100micrograms inhaler	2.3	3.0	4.7	2.2	-0.8	-2.2	1.4	1.2	-2.1
Leg fat mass (right)	2.2	8.6	22.9	-1.0	3.1	0.4	4.8	1.7	-3.9
Schizophrenia vs Biploar Disorder	2.1	2.8	7.4	-0.7	-1.7	-0.9	-2.7	-2.3	0.0
Age at first live birth	2.1	3.8	9.0	2.6	-3.0	-1.3	-2.0	-1.2	0.1
Intelligence (Savage-Jansen 2018)	2.0	6.1	17.2	4.2	-1.5	-1.4	-0.4	1.7	-3.5
Medication: Levothyroxine sodium	2.0	3.3	8.4	-2.2	1.7	1.6	0.8	2.9	0.9
Prospective memory result	2.0	2.5	5.7	-1.7	2.4	-0.2	0.0	2.2	1.2
Pulse wave reflection index	2.0	2.5	5.2	2.3	-2.0	-0.5	0.0	-0.6	-2.2
Friendships satisfaction	2.0	2.5	5.8	1.4	-0.3	0.0	2.1	1.6	-2.4
Eye problems/disorders: Cataract	2.0	2.3	5.2	1.4	-2.3	-0.9	-1.2	-2.1	0.4
Smoking status: Current	2.0	3.2	6.1	-1.3	2.1	1.9	2.5	1.0	-1.4
Leg fat percentage (left)	2.0	7.1	21.3	-0.7	2.1	0.2	4.6	1.2	-3.8
Blood Red Count	1.9	18.2	37.5	-3.1	0.4	1.5	-6.1	-4.8	6.0
Qualifications: None of the above	1.9	4.1	10.3	-3.2	2.6	0.4	0.7	1.6	2.2
Qualifications: A levels/AS levels or equivalent	1.9	4.2	11.7	3.4	-2.0	-1.4	-1.2	1.4	-2.0
Qualifications: College or University degree	1.9	5.9	14.4	3.8	-2.9	-1.6	-2.8	-0.4	-1.4
Whole body fat mass	1.9	7.8	21.7	-1.0	2.9	0.6	4.7	1.5	-3.6
Pain experienced in last month	1.9	3.2	6.4	2.3	-2.5	-1.5	-1.8	-1.4	0.0
Vitamin and mineral supplements	1.8	2.4	6.7	0.3	-2.5	-0.6	-0.6	-2.6	1.0
Supplements: Zinc	1.8	1.9	5.4	2.0	-0.9	-2.3	-1.0	0.0	-0.8
Pulse rate	1.8	3.1	9.2	0.4	-0.3	-0.4	-3.0	-2.1	2.2
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	6.4	-0.7	0.3	-0.5	2.5	1.4	-1.9
Breastfed as a baby	1.8	2.3	6.6	1.2	0.0	-0.6	0.6	2.2	-2.6
Risk taking	1.8	2.6	5.2	2.3	-1.7	-1.0	1.5	-1.5	-1.5
Fractured/broken bones in last 5 years	1.8	2.3	7.8	1.9	-0.3	0.5	1.4	0.4	-2.8
Bipolar Disorder (2018)	1.7	2.7	8.0	-0.3	2.0	-1.3	1.6	2.8	0.0
Major Depression (MDD)	1.7	2.1	4.3	-1.3	1.6	-0.2	2.1	1.9	0.0
Systolic Blood Pressure	1.7	8.4	16.6	-1.7	-3.7	-1.7	-1.3	-4.1	3.6
Smoking Status	1.7	4.0	10.7	-1.5	1.7	0.7	3.3	2.1	-1.8
Current tobacco smoking	1.7	2.8	5.6	-1.0	2.1	1.5	2.4	1.1	-1.5
Trunk fat mass	1.7	7.3	19.9	-1.3	3.1	0.7	4.5	1.5	-3.1
Number of incorrect matches in round	1.7	2.8	10.3	-1.2	0.7	-0.4	-2.0	0.2	3.2
Medication: Ramipril	1.7	2.2	6.6	-2.6	1.1	0.4	1.5	-0.9	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	8.0	-0.8	2.8	0.9	1.0	1.5	0.0
Leg fat percentage (right)	1.7	6.2	18.5	-0.8	2.3	-0.1	4.3	0.9	-3.5
Medication: Gliclazide	1.7	1.9	4.8	1.0	-0.7	-1.1	1.5	1.3	-2.2
Hearing aid user	1.7	1.9	8.1	1.4	0.8	0.2	0.9	-0.1	-2.8
Depressed Affect (Nagel 2018)	1.6	3.3	7.6	-1.1	2.3	1.3	2.8	1.8	-0.5
Respiratory disease	1.6	3.6	8.0	0.4	0.2	-2.6	2.8	2.0	-1.6
Waist circumference	1.6	5.7	15.1	-0.9	2.4	0.9	3.9	1.2	-3.2
Weight	1.6	7.9	20.1	-0.4	2.6	1.0	4.5	1.8	-4.0
Hip circumference	1.6	6.7	19.6	0.9	1.1	0.2	4.3	0.6	-4.4
Arm fat mass (right)	1.6	6.8	19.4	-0.6	2.5	1.0	4.4	1.2	-3.5
Shortness of breath walking on level ground	1.6	1.9	5.3	2.3	-0.8	-1.3	-0.9	-1.4	-0.9
Migraine (self-reported)	1.6	2.0	4.0	-1.9	2.0	1.1	0.7	1.4	0.7
Overall health rating	1.6	3.5	11.5	-1.2	2.2	-0.3	3.4	1.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	14.9	0.8	0.2	1.4	-3.9	-0.9	1.5
Arm fat mass (left)	1.6	6.5	18.9	-0.6	2.5	1.0	4.3	1.0	-3.4
Tinnitus: Yes, now most or all of the time	1.6	1.8	5.8	2.4	-0.9	-0.6	-1.8	-0.5	-0.6
Alcohol drinker status: Never	1.6	1.9	3.5	-1.5	1.9	1.9	-0.5	1.4	-0.2
Ever had prostate specific antigen (PSA) test	1.6	1.8	6.1	1.1	-1.7	-0.6	-2.5	0.0	0.4
Arm predicted mass (left)	1.6	8.1	18.8	0.0	2.0	0.9	4.3	2.5	-4.3
Maternal smoking around birth	1.5	2.2	5.0	-2.2	1.1	0.8	0.2	1.5	2.0
Multivitamins +/- minerals	1.5	1.9	4.6	-0.1	1.8	0.0	1.4	2.2	-1.3
Body mass index (BMI)	1.5	6.3	17.2	-0.1	2.1	1.1	4.1	0.5	-3.8
Fluid intelligence score	1.5	3.1	11.1	3.3	-2.0	-1.1	-0.7	-0.9	-1.0
Asthma	1.5	2.9	7.3	1.5	-0.7	-2.7	2.0	0.9	-1.6
Pulse wave Arterial Stiffness index	1.5	1.8	7.3	1.6	-0.5	0.3	0.9	0.1	-2.7
Body fat percentage	1.5	5.8	17.4	-1.2	2.6	0.3	4.2	0.8	-2.9
Arm fat-free mass (right)	1.5	7.7	20.0	0.5	1.6	0.8	4.4	1.9	-4.5
Pulse wave peak to peak time	1.5	1.8	6.5	-1.7	0.8	-0.3	-0.6	0.4	2.5
Arm predicted mass (right)	1.5	7.6	18.7	0.2	1.9	1.1	4.3	1.9	-4.3
Age at last live birth	1.5	2.2	7.2	1.4	-2.7	-0.9	-0.6	-1.5	0.4
Osteoarthritis (self-reported)	1.5	1.9	4.8	1.9	-2.2	-1.7	-0.4	-0.2	0.0
Ever taken oral contraceptive pill	1.5	1.7	3.1	1.8	-1.6	-1.0	-0.1	-1.6	-0.9
Arm fat-free mass (left)	1.5	7.6	18.3	0.1	1.9	0.9	4.3	2.5	-4.1
Commuting to job workplace: Cycle	1.5	1.8	4.7	2.2	-1.2	-0.6	-0.3	0.6	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	7.7	-0.3	2.1	-0.4	1.6	2.8	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.6	-1.5	0.8	1.4	-1.6	-0.9	1.0
Asthma (self-reported)	1.4	2.9	8.3	1.4	-0.6	-2.9	1.9	0.9	-1.4
Supplements: Calcium	1.4	1.5	3.2	-1.0	1.3	1.8	-0.0	1.0	-1.4
BMI	1.3	7.8	22.1	0.3	1.8	0.8	4.7	0.8	-4.5
Trunk fat percentage	1.3	5.1	14.8	-1.4	2.7	0.5	3.9	0.5	-2.5
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	19.5	1.3	0.2	0.9	-4.4	-0.7	1.8
Chest pain or discomfort	1.3	1.9	4.0	-1.3	2.0	0.3	2.0	1.4	0.2
Loneliness, isolation	1.3	1.8	3.1	-1.6	1.4	1.5	1.8	-0.5	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	3.4	-1.5	1.9	1.0	1.2	1.1	-0.3
Medication: Bendroflumethiazide	1.3	1.9	6.7	1.0	-1.7	-2.6	-0.3	-0.9	0.2
Schizophrenia (2018)	1.2	2.4	11.4	-3.4	0.2	-1.1	-1.0	-0.8	0.0
Schizophrenia (2014)	1.2	2.7	11.8	-3.4	0.4	-1.7	-1.2	-0.2	0.0
Chronotype (morning person)	1.2	2.7	6.5	-2.6	0.7	2.3	0.6	-1.5	1.2
Hearing difficulty/problems: Yes	1.2	1.8	5.2	2.3	-1.4	-0.5	-1.6	0.0	-0.9
Age when periods started (menarche)	1.2	2.9	8.0	0.8	-0.8	-1.4	-2.8	-1.1	2.2
Illnesses of mother	1.2	1.4	4.6	2.1	-0.8	-1.1	-1.2	-0.8	0.2
Peak expiratory flow (PEF)	1.2	2.8	8.4	0.1	1.2	2.9	-2.6	0.3	-0.2
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.9	0.4	1.0	1.8	0.9	1.2	-2.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.4	-0.8	0.3	2.1	-0.5	-1.6	0.5
Mother’s age at death	1.2	1.6	3.9	2.0	-1.0	-0.2	-1.9	-0.9	-0.2
Crohns Disease (2017)	1.1	2.4	4.6	2.2	-1.3	-1.9	0.2	0.2	-2.2
Coronary Artery Disease (CAD)	1.1	1.3	6.0	-2.4	-0.4	1.2	0.5	0.4	0.0
Lung FVC	1.1	5.7	20.3	2.3	-1.0	0.8	-4.5	-2.6	0.3
Sensitivity / hurt feelings	1.1	1.9	4.4	-1.1	1.0	2.0	2.1	-0.0	-0.9
Taking other prescription medications	1.1	1.7	7.7	0.6	-0.3	-2.8	0.9	1.2	-0.2
Nervous feelings	1.1	2.0	4.4	-1.7	0.7	1.0	-2.1	0.3	1.8
Worry too long after embarrassment	1.1	1.8	7.0	0.3	0.4	2.6	1.0	0.8	-1.3
Health satisfaction	1.1	1.4	2.0	1.0	1.2	-1.2	1.2	1.2	-1.4
Medication: Blood pressure	1.1	2.0	6.1	-1.2	-0.4	-1.6	-0.4	-1.1	2.5
Miserableness	1.1	1.9	4.6	-1.4	1.0	1.5	2.1	1.2	0.1
Guilty feelings	1.1	1.6	4.2	-0.6	1.2	0.9	1.7	2.0	-0.2
Basal metabolic rate	1.1	6.3	14.6	0.1	2.0	1.1	3.8	2.1	-3.7
Bipolar Disorder or Schizophrenia	1.0	2.3	7.7	-2.8	1.4	-1.7	0.3	1.2	0.0
Alzheimer’s Disease (in father)	1.0	1.1	4.2	-0.0	0.7	-0.3	2.0	0.1	-1.4
Severe depression (siblings)	1.0	1.1	3.9	0.5	0.4	0.2	2.0	0.8	-1.3
Leg fat-free mass (left)	1.0	5.4	11.1	-0.2	2.5	1.4	3.3	1.7	-3.2
Leg predicted mass (left)	1.0	5.4	11.1	-0.3	2.5	1.5	3.3	1.6	-3.2
Mouth/teeth dental problems	1.0	1.5	3.1	1.8	-1.7	-1.1	-0.5	-0.2	-1.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.1	1.8	-1.6	-0.9	-1.1	0.4	-0.3
Impedance of arm (right)	1.0	4.5	16.6	-1.8	-0.1	-0.5	-2.6	-0.1	4.1
Arm fat percentage (right)	1.0	3.9	11.8	-0.9	2.4	0.7	3.4	0.6	-2.2
Falls in the last year	1.0	1.4	2.3	1.0	0.1	-1.3	1.5	-0.9	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	13.1	1.1	-0.5	1.0	-3.6	-1.1	1.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	4.5	1.1	-0.1	-0.3	1.4	1.5	-2.1
Medication: Seretide 50 evohaler	1.0	1.2	4.3	1.4	0.6	-2.1	0.5	-0.0	-0.4
Had major operations	1.0	1.1	3.3	-1.5	0.6	0.5	0.5	0.4	1.8
Whole body fat-free mass	1.0	5.7	12.2	0.2	1.9	1.2	3.5	2.3	-3.5
Arm fat percentage (left)	1.0	4.0	12.3	-0.7	2.3	0.7	3.5	0.0	-2.4
Bipolar Disorder (2011)	0.9	0.9	5.2	0.0	0.0	0.0	0.0	2.3	0.0
LDL Cholesterol	0.9	1.4	3.8	-1.0	1.2	0.9	1.1	1.9	0.0
Heel T-Score	0.9	7.2	20.9	2.5	-3.0	-4.6	-1.3	-2.2	0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.7	-1.6	0.6	1.6	0.4	0.5	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.4	0.1	1.8	0.8	0.4	1.3	-0.9
Had other major operations	0.9	1.2	3.0	-0.4	0.7	-0.6	1.7	0.5	-1.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.6	1.4	0.1	-1.9	0.4	0.2	-1.0
Happiness	0.9	1.2	2.4	1.6	-0.4	-1.2	0.9	0.4	-1.3
Impedance of arm (left)	0.9	4.1	14.3	-1.2	-0.5	-1.0	-2.4	-1.4	3.8
Trunk predicted mass	0.9	5.1	10.8	0.4	1.5	0.8	3.3	2.6	-3.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.6	-0.3	-0.4	1.6	0.3	-1.9	1.0
Birth weight	0.9	1.9	7.4	-0.1	2.7	1.2	-0.8	1.0	-0.9
Number of full sisters	0.9	1.1	4.0	-0.7	0.1	0.6	2.0	-0.4	-1.2
Commuting to job workplace: Car/motor vehicle	0.9	1.1	4.6	-0.6	0.8	-0.3	2.2	0.5	-0.7
Leg fat-free mass (right)	0.9	5.0	10.6	0.1	2.0	1.7	3.2	1.5	-3.3
Diabetes diagnosed by doctor	0.9	1.5	3.7	-1.2	-0.1	1.2	1.9	1.2	-1.1
Whole body water mass	0.9	5.1	11.6	0.4	1.7	1.0	3.2	2.2	-3.4
Leg predicted mass (right)	0.9	4.9	10.7	0.2	1.9	1.6	3.2	1.5	-3.3
Number of self-reported non-cancer illnesses	0.9	1.6	5.3	0.2	-0.9	-2.3	1.0	1.6	0.4
Ever smoked	0.9	1.6	3.6	1.1	-0.3	-1.3	1.2	1.2	-1.9
Cholesterol lowering medication	0.9	1.4	4.4	-0.4	0.3	0.3	2.1	0.5	-1.8
Depression (Nagel 2018)	0.8	1.2	2.3	1.5	-0.5	-0.8	1.4	0.1	-1.4
Worry (Nagel 2018)	0.8	1.7	3.3	-1.8	1.0	1.1	-1.3	-0.3	1.6
Irritable Bowel Disease (IBD)	0.8	2.0	7.2	1.2	-1.4	-2.7	0.4	-0.5	-1.0
Crohns Disease (2012)	0.8	1.4	3.2	1.8	-1.3	-1.5	-0.3	-0.9	0.0
Average weekly spirits intake	0.8	1.0	3.2	0.2	0.3	-1.1	1.8	0.7	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	3.5	1.6	-1.9	-1.2	-1.4	-1.0	-0.3
High blood pressure	0.8	2.2	3.5	-0.9	-1.2	-1.9	1.2	-1.9	1.5
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.8	1.9	-1.7	-1.6	-0.4	-0.6	-1.0
Forced vital capacity (FVC)	0.8	3.1	14.0	0.6	0.5	0.5	-3.7	-0.1	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	4.3	1.7	-2.1	-0.9	-1.0	-1.1	-0.4
Illnesses of siblings	0.8	1.2	3.0	-0.9	1.7	1.0	-0.8	1.1	0.6
Trunk fat-free mass	0.8	4.8	9.5	0.4	1.5	0.7	3.1	2.6	-3.1
Father’s age at death	0.8	1.1	4.4	2.1	-0.7	0.1	-0.7	0.5	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.1	2.7	0.6	0.7	-1.6	0.8	1.0	-1.3
Comparative body size at age 10	0.8	2.2	7.8	2.8	-0.3	-1.5	0.1	-0.2	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.3	0.5	1.5	0.5	0.7	-0.1	-1.8
Eye problems/disorders: None of the above	0.8	0.9	3.5	0.2	1.1	0.3	-0.3	1.9	-0.7
Medication for cholesterol	0.8	1.1	2.6	0.1	0.9	1.4	-1.6	-0.4	1.2
Eye problems/disorders: Glaucoma	0.8	0.9	4.2	-0.1	0.8	-0.4	2.1	0.5	-0.5
Number of operations (self-reported)	0.8	1.2	2.5	-0.9	1.6	-0.3	1.4	1.2	0.4
Alzheimer’s Disease (in mother)	0.7	0.9	2.2	-1.2	0.7	1.5	0.5	0.2	0.9
Primary Biliary Cirrhosis	0.7	1.0	4.4	0.5	0.6	-0.1	0.8	0.7	-2.1
Blood Eosinophil Count	0.7	5.3	12.4	-3.5	-1.7	1.4	-1.1	-2.2	3.0
Number of treatments/medications taken	0.7	1.3	2.8	-0.1	1.4	-1.7	0.7	1.5	-0.3
Angina	0.7	0.9	2.5	0.1	1.1	0.4	1.1	0.7	-1.6
Medication: Co-codamol	0.7	0.8	1.7	-1.3	1.1	0.4	1.0	0.9	0.4
Qualifications: CSEs or equivalent	0.7	0.9	2.0	0.0	1.0	1.4	0.8	0.5	-1.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.6	-0.8	1.2	-0.8	0.2	1.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.6	0.7	0.7	0.8	1.9	-0.1	-1.1
Lung cancer (father)	0.7	0.8	3.2	-1.0	-0.6	-0.5	-0.2	-0.1	1.8
High blood pressure (siblings)	0.7	1.0	2.6	0.9	-1.6	-0.8	0.7	-1.1	-0.2
Neck or shoulder pain in last month	0.7	1.0	1.6	0.3	1.2	0.3	1.2	1.0	-1.3
Angina (self-reported)	0.7	1.0	2.8	0.2	1.0	0.4	1.2	0.5	-1.7
Medication: Ibuprofen	0.7	0.8	4.0	0.2	2.0	0.3	0.8	0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.0	1.4	-0.7	-0.3	-1.1	1.2	-0.5
Hypertension (Self-reported)	0.7	2.0	4.6	-0.8	-1.2	-2.1	1.1	-1.4	1.4
Smoking status: Previous	0.7	1.0	2.8	-0.7	0.3	-1.0	1.3	1.7	-0.5
Ever had bowel cancer screening	0.7	0.8	1.9	-0.9	0.1	-0.7	-0.5	1.4	1.1
Qualifications: nursing, teaching	0.7	1.0	3.7	1.4	-0.2	-0.0	0.1	0.7	-1.9
Mineral and other dietary supplements	0.7	0.9	3.1	-1.2	-0.3	-0.2	-0.1	-0.8	1.8
Medication: Lisinopril	0.7	0.9	2.8	0.9	0.0	-1.7	-0.4	-0.9	0.8
Neuroticism (Nagel 2018)	0.6	1.5	3.1	-0.8	1.5	1.8	1.3	0.9	-0.4
HDL Cholesterol	0.6	1.0	2.3	1.5	-1.0	-1.5	0.1	-0.6	0.0
Blood Platelet Count	0.6	6.9	30.8	0.5	-3.0	0.6	0.2	-5.5	-1.1
Cardiovascular Disease	0.6	2.1	2.9	-1.0	-1.6	-1.3	1.2	-1.7	1.7
Systolic blood pressure, automated reading	0.6	1.9	4.1	-0.8	-2.0	-1.9	0.9	-1.3	0.5
Diabetes (father)	0.6	0.7	2.4	1.0	-1.5	-0.5	0.2	0.7	-0.3
Hand grip strength (right)	0.6	1.7	4.3	-0.1	-2.1	-0.7	-1.2	-1.3	1.5
High blood pressure (mother)	0.6	0.8	2.5	-0.1	-0.5	-1.6	0.9	-0.4	-1.0
Alcohol usually taken with meals	0.6	0.9	3.0	0.4	1.7	0.6	-0.1	1.3	-0.6
Hair/balding pattern: Pattern 2	0.6	0.8	1.8	0.9	-1.3	0.2	-0.7	-1.3	0.1
Allergy	0.6	1.3	3.5	-1.3	1.0	1.9	-0.6	-0.2	1.0
Pain all over the body in last month	0.6	0.6	1.2	-0.8	1.1	1.0	-0.8	-0.4	-0.1
Medication: Simvastatin	0.6	0.8	1.7	-0.2	-1.2	-1.2	1.3	-0.3	-0.1
Hair/balding pattern: Pattern 3	0.6	0.8	1.9	0.2	-0.9	-1.1	-1.0	-0.1	1.4
Exposure to tobacco smoke at home	0.6	0.7	1.5	-0.5	-0.7	1.2	0.5	-1.2	0.0
Birth weight of first child	0.6	1.0	1.6	-0.0	1.3	1.3	-1.3	-0.2	1.2
Glaucoma (self-reported)	0.6	0.7	2.8	-0.1	0.9	-0.5	1.7	0.4	-0.5
Number of children fathered	0.6	0.7	2.2	-1.2	0.2	1.5	-0.5	0.3	0.5
Comparative height size at age 10	0.6	3.4	10.7	-1.6	1.7	-0.8	1.8	3.3	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	-0.2	0.2	0.9	1.1	0.8	-1.2
Medication: Aspirin	0.6	0.8	2.4	-0.7	0.4	-1.3	-0.6	0.1	1.5
Supplements: Vitamin C	0.6	0.7	2.5	-1.0	1.6	0.1	0.1	0.3	0.7
Average weekly red wine intake	0.6	0.9	1.6	0.8	-0.6	-1.3	-1.0	1.2	0.3
Mood swings	0.6	1.1	5.5	-0.4	0.6	0.0	2.4	-0.2	0.6
Commuting to job workplace: Walk	0.6	0.7	2.3	-0.6	0.7	-0.4	-0.7	0.1	1.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.6	-0.9	1.0	0.3	1.6	1.0	-0.6
Medication: Aspirin	0.6	0.8	2.0	-0.4	0.2	-1.4	-0.8	0.3	1.3
Medication: Blood pressure	0.6	1.1	3.9	0.0	-1.1	-2.0	0.8	-0.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.6	0.7	2.6	1.2	-0.3	-0.1	-0.1	0.6	-1.6
Vascular/heart problems diagnosed by doctor	0.6	1.8	2.2	1.4	0.9	1.5	-1.3	1.3	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.0	-0.9	0.3	1.0	0.9	-0.8	0.7
Ulcerative Colitis (UC)	0.5	0.9	3.8	-0.6	-0.4	-1.9	0.6	-0.7	0.4
Ovarian Cancer	0.5	0.7	2.6	-1.0	0.5	0.2	0.4	-0.3	1.6
Lupus	0.5	0.8	3.2	-1.8	-0.0	0.6	-0.5	1.1	0.0
Triglycerides	0.5	0.9	4.4	-0.4	-0.3	0.7	2.1	0.5	0.0
Ulcerative Colitis	0.5	0.8	2.6	-0.6	-0.5	-1.6	-0.1	-1.2	0.0
Blood White Count	0.5	3.9	12.0	-3.5	1.3	2.6	-0.3	-0.7	1.7
Waist Hip Ratio (WHR)	0.5	2.1	6.5	-2.5	2.1	0.7	0.1	0.7	1.1
Tanning	0.5	6.6	16.9	3.1	-4.1	0.0	-2.0	-3.0	0.0
Medication: Metformin	0.5	0.7	1.6	-0.5	-0.1	1.1	0.9	0.1	-1.3
Average weekly fortified wine intake	0.5	0.6	1.5	0.9	-1.2	-1.1	-0.1	0.2	-0.6
Supplements: Glucosamine	0.5	0.6	1.4	1.1	-0.9	-0.4	0.0	0.3	-1.2
Past tobacco smoking	0.5	0.9	2.4	0.5	-0.3	0.4	-1.3	-1.5	0.9
Hearing difficulty/problems with background noise	0.5	0.7	1.9	0.9	-1.4	-0.2	-1.1	-0.6	0.3
Had menopause	0.5	0.6	1.2	-1.1	0.1	-0.4	0.5	-1.1	0.8
Neuroticism score	0.5	1.0	2.1	-0.6	0.8	1.5	1.5	0.9	-0.1
Blood clot in the leg (DVT)	0.5	0.6	1.3	-1.1	0.3	1.0	-0.2	-0.4	1.0
Forced vital capacity (FVC), Best measure	0.5	1.8	7.4	0.3	0.2	1.1	-2.7	-0.0	1.5
Wheeze or whistling in the chest in last year	0.5	0.9	2.3	-0.2	0.1	-0.7	1.5	0.7	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-0.0	-0.9	-1.2	-0.6	-1.0	0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.5	0.8	-0.2	0.9	-0.8	-0.8	0.9	0.5
Suffer from ‘nerves’	0.5	0.7	1.3	0.7	-0.6	-1.1	-0.6	-0.9	1.1
Back pain experienced in last month	0.5	0.8	1.6	-1.3	1.2	0.3	0.3	-1.1	0.6
Wears glasses or contact lenses	0.5	0.6	1.6	0.8	0.0	-1.3	-1.1	0.1	0.1
Illnesses of father: High blood pressure	0.5	0.7	2.9	-0.9	0.2	1.7	0.4	-0.4	0.0
Ever depressed for a whole week	0.5	0.7	1.7	0.0	1.3	-1.1	0.2	1.0	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.5	-1.2	0.6	0.9	-0.1	-0.3	1.0
Impedance of whole body	0.5	2.7	8.7	-1.7	-0.5	-1.3	-1.4	-0.6	2.9
Reaction Time	0.4	0.8	2.9	-0.8	1.0	0.5	1.7	-0.2	0.5
Fasting Glucose	0.4	0.5	2.4	0.1	0.3	-1.6	0.6	0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.2	1.0	0.3	-1.1	0.1	0.6	0.0
Lung FEV1/FVC ratio	0.4	2.0	9.2	1.5	-0.1	0.4	-3.0	-0.3	0.4
Neuroticism	0.4	1.0	1.8	-0.4	0.9	1.3	1.1	1.3	-0.5
Medication for hormone replacement therapy	0.4	0.5	1.8	-0.8	-0.3	-0.1	1.3	-0.4	0.4
Impedance of leg (right)	0.4	1.7	4.2	-1.5	-0.4	-2.1	-0.6	-0.1	1.8
Fed-up feelings	0.4	0.8	1.5	-0.6	1.2	1.1	1.1	-0.5	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	0.8	-0.3	-0.3	1.4	0.1	-0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.3	-0.1	-0.6	0.1	1.5	-0.2	0.1
Financial difficulties in last 2 years	0.4	0.6	2.0	-0.7	0.1	0.2	1.4	0.3	0.9
Diabetes (self-reported)	0.4	0.6	1.6	-0.3	-0.8	0.4	1.3	0.8	-0.8
Mouth/teeth dental problems: Dentures	0.4	0.6	1.2	-1.1	1.1	0.5	-0.3	-0.0	1.0
Medication: Cholesterol lowering	0.4	0.6	2.0	0.2	-0.7	-1.4	-0.2	-0.1	1.1
Hair/balding pattern: Pattern 4	0.4	0.9	1.3	-1.0	1.1	0.6	-0.9	1.0	0.9
Loud music exposure frequency	0.4	0.4	1.2	0.1	0.4	-1.1	1.1	-0.4	-0.1
Gout (self-reported)	0.4	0.6	2.6	-1.6	0.0	-0.1	0.3	0.7	0.3
Medication: Amlodipine	0.4	0.6	2.7	0.5	-0.6	-1.6	-0.0	0.1	0.1
Medication: Allopurinol	0.4	0.6	2.0	-1.4	-0.4	-0.8	0.5	0.4	0.6
Mean time to correctly identify matches	0.4	0.8	2.1	-0.7	1.3	0.7	1.4	0.4	0.5
Heart disease (mother)	0.4	0.5	1.5	-0.3	-1.0	-0.1	-0.2	1.2	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-0.2	-0.3	0.1	-0.9	-0.7	1.2
Illnesses of father: Heart disease	0.4	0.5	1.1	1.0	-0.1	-0.5	0.3	-0.9	-0.8
Illnesses of siblings: Diabetes	0.4	0.5	2.7	0.5	-1.6	0.1	-0.3	0.4	-0.4
High cholesterol (Self-reported)	0.4	0.6	1.1	0.5	-0.8	-1.0	1.1	0.9	-0.0
Medication: Atorvastatin	0.4	0.5	1.5	-0.2	0.4	-1.2	-0.9	0.6	0.7
Irritability	0.4	0.7	1.3	0.9	-0.3	0.7	0.9	1.0	-1.1
Unable to work because of sickness or disability	0.4	0.5	2.1	-0.0	1.0	0.4	1.4	0.0	-0.4
Myopia	0.4	0.6	2.3	0.4	-0.3	0.0	-1.5	-0.5	0.9
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	0.2	0.8	-0.2	-1.2	-0.5	0.7
HbA1C	0.3	0.3	1.1	-0.2	-0.4	0.6	-1.1	-0.4	0.0
Height	0.3	5.8	20.7	-1.0	2.1	-1.4	2.3	4.6	-1.2
Allergy or Eczema	0.3	0.9	1.7	1.0	-0.9	-1.3	0.2	0.8	-1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	-0.1	-0.7	-1.2	0.1	-0.6	0.1
Relative age voice broke	0.3	0.5	1.5	0.1	-1.2	0.9	-0.3	-0.6	0.1
Serious illness, injury or assault to yourself	0.3	0.4	1.3	0.8	0.5	0.1	0.4	-0.3	-1.1
Time employed in main current job	0.3	0.4	1.0	0.0	0.4	-0.4	-1.0	-0.5	0.9
Worrier / anxious feelings	0.3	0.6	0.9	-0.8	1.0	0.2	-0.6	0.8	0.9
Depression (self-reported)	0.3	0.4	1.8	1.3	-0.1	-0.5	0.0	0.4	0.1
Medication: Lansoprazole	0.3	0.3	0.9	-0.9	-0.4	-0.1	-0.0	-0.8	0.2
Standing height	0.3	2.7	10.1	-0.6	1.5	-0.3	1.5	3.2	-1.2
Tense / ‘highly strung’	0.3	0.5	1.2	-1.1	0.6	0.3	0.5	0.8	0.6
Number of full brothers	0.3	0.3	0.9	0.5	0.7	-0.5	-1.0	0.3	0.3
Alcohol intake frequency.	0.3	0.7	2.0	-0.3	1.2	0.1	-1.4	0.4	0.9
Knee pain experienced in last month	0.3	0.5	1.2	0.2	-0.6	-1.1	1.0	-0.7	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.0	-0.0	-1.0	-0.3	0.0	-0.6	-0.8
Long-standing illness, disability or infirmity	0.3	0.4	1.6	-0.1	0.7	-0.5	1.3	0.2	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.3	1.3	0.5	-0.0	-0.4	-0.0	1.1	-0.6
Financial situation satisfaction	0.3	0.3	1.0	0.8	0.1	-1.0	-0.3	0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.1	-0.5	-0.5	-1.0	1.0	0.3	0.1
Age started oral contraceptive pill	0.3	0.3	0.9	0.4	-0.5	-0.2	0.4	-0.9	-0.8
Mean Putamen Volume	0.2	0.2	0.7	-0.5	0.8	0.4	0.5	0.2	0.0
Rheumatoid Arthritis	0.2	0.2	1.1	0.5	0.1	1.0	0.1	-0.2	-0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	-0.8	-0.2	0.2	1.2	0.5	-0.5
Hand grip strength (left)	0.2	0.5	2.7	0.2	-1.7	-0.3	-0.1	0.1	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.1	0.4	-0.1	-0.2	1.1	-0.8	-0.2
Relative age of first facial hair	0.2	0.4	1.3	-1.2	-0.5	0.5	0.4	-0.4	0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.3	-0.0	-0.3	0.2	0.5	1.1	0.1
Medication: Atenolol	0.2	0.3	1.0	-1.0	-0.4	-0.8	-0.2	-0.2	0.1
Sitting height	0.2	1.4	2.9	0.9	-0.3	-0.2	1.7	1.2	-1.7
Impedance of leg (left)	0.2	1.0	2.2	-1.5	-0.6	-1.4	-0.0	0.2	1.3
Alcohol intake versus 10 years previously	0.2	0.4	1.5	-0.1	1.2	-0.4	0.4	-0.2	-0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.1	0.8	-0.1	0.3	0.8	-0.2
Medication: Omeprazole	0.2	0.3	0.8	0.2	0.3	0.3	0.2	-0.8	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.5	-0.3	0.3	0.8	0.1	0.4
Breast cancer (self-reported)	0.2	0.3	1.1	0.3	-1.1	-0.5	-0.2	0.2	0.1
Osteoporosis (self-reported)	0.2	0.3	0.5	0.4	-0.2	-0.6	-0.7	0.7	0.3
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.3	0.3	0.6	0.3	-0.4	-0.7
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.4	-0.4	0.7	-0.8	-0.3	0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	1.0	-0.2	0.0	0.2	-0.0	-1.0	-0.5
Hair Pigment	0.1	2.7	5.1	-1.8	1.4	1.2	2.2	1.8	-1.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.6	-0.2	-0.3	0.4	0.2	-0.4
Diabetes (mother)	0.1	0.2	0.3	-0.3	0.5	-0.2	0.4	-0.2	-0.6
Townsend deprivation index at recruitment	0.1	0.2	0.5	0.6	0.4	-0.4	-0.1	0.2	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	0.1	0.2	-0.4	0.6	-0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.2	-0.1	-0.6	-0.0	0.2	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heart attack	0.0	0.1	0.3	0.1	0.0	-0.6	-0.0	0.0	-0.1

Hub : Genes

ATP2A2

Models

Trait associations