Hub : Genes

ATP2A2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0300 0.0180 7.8e-03 0.019 0.009 0.006 0.011 0.015 2.1e-03 0.0240 6.0e-02 0.014 4.9e-03
2 GTEx Artery Tibial 0.1126 0.0473 3.0e-04 -0.003 NA 0.032 NA 0.003 9.0e-01 NA 1.4e-03 NA 1.9e-01
3 GTEx Brain Caudate basal ganglia 0.1830 0.0870 3.9e-03 0.070 NA 0.040 NA 0.023 4.8e-03 NA 2.7e-02 NA 7.4e-02
4 GTEx Esophagus Muscularis 0.1370 0.0480 2.6e-06 0.134 NA 0.104 NA 0.122 1.6e-08 NA 7.2e-07 NA 7.6e-08
5 NTR Blood 0.0263 0.0146 6.5e-03 0.001 0.001 0.002 0.003 0.001 1.8e-01 0.1300 5.5e-02 0.038 1.2e-01
6 TCGA Prostate Adenocarcinoma 0.0371 0.0214 3.7e-03 0.026 0.015 0.020 NA 0.028 8.0e-04 0.0084 3.5e-03 NA 6.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.7 2.7 8.0 -0.3 2.0 -1.3 1.6 2.8 0.0
Bipolar Disorder or Schizophrenia 1.0 2.3 7.7 -2.8 1.4 -1.7 0.3 1.2 0.0
Depressed Affect (Nagel 2018) 1.6 3.3 7.6 -1.1 2.3 1.3 2.8 1.8 -0.5
Depression (Nagel 2018) 0.8 1.2 2.3 1.5 -0.5 -0.8 1.4 0.1 -1.4
Intelligence (Savage-Jansen 2018) 2.0 6.1 17.2 4.2 -1.5 -1.4 -0.4 1.7 -3.5
Neuroticism (Nagel 2018) 0.6 1.5 3.1 -0.8 1.5 1.8 1.3 0.9 -0.4
Schizophrenia (2018) 1.2 2.4 11.4 -3.4 0.2 -1.1 -1.0 -0.8 0.0
Schizophrenia vs Biploar Disorder 2.1 2.8 7.4 -0.7 -1.7 -0.9 -2.7 -2.3 0.0
Worry (Nagel 2018) 0.8 1.7 3.3 -1.8 1.0 1.1 -1.3 -0.3 1.6
Alzheimer’s Disease (in mother) 0.7 0.9 2.2 -1.2 0.7 1.5 0.5 0.2 0.9
Alzheimer’s Disease (in father) 1.0 1.1 4.2 -0.0 0.7 -0.3 2.0 0.1 -1.4
Alzheimer’s Disease (including proxy) 0.5 0.7 1.0 -0.9 0.3 1.0 0.9 -0.8 0.7
Crohns Disease (2017) 1.1 2.4 4.6 2.2 -1.3 -1.9 0.2 0.2 -2.2
Irritable Bowel Disease (IBD) 0.8 2.0 7.2 1.2 -1.4 -2.7 0.4 -0.5 -1.0
Ulcerative Colitis (UC) 0.5 0.9 3.8 -0.6 -0.4 -1.9 0.6 -0.7 0.4
Major Depression (MDD) 1.7 2.1 4.3 -1.3 1.6 -0.2 2.1 1.9 0.0
Reaction Time 0.4 0.8 2.9 -0.8 1.0 0.5 1.7 -0.2 0.5
Verbal and Numeric Reasoning (VNR) 2.4 5.7 18.8 4.3 -1.6 -2.4 -1.6 0.6 -1.9
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.5 0.7 2.6 -1.0 0.5 0.2 0.4 -0.3 1.6
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 3.1 4.5 9.2 2.4 -3.0 -1.2 -2.7 -1.9 0.0
Bipolar Disorder (2011) 0.9 0.9 5.2 0.0 0.0 0.0 0.0 2.3 0.0
Body Mass Index (BMI) (2010) 3.0 4.2 13.8 0.4 1.7 -0.0 3.7 2.9 0.0
Coronary Artery Disease (CAD) 1.1 1.3 6.0 -2.4 -0.4 1.2 0.5 0.4 0.0
Crohns Disease (2012) 0.8 1.4 3.2 1.8 -1.3 -1.5 -0.3 -0.9 0.0
Mean Putamen Volume 0.2 0.2 0.7 -0.5 0.8 0.4 0.5 0.2 0.0
Fasting Glucose 0.4 0.5 2.4 0.1 0.3 -1.6 0.6 0.1 0.0
HbA1C 0.3 0.3 1.1 -0.2 -0.4 0.6 -1.1 -0.4 0.0
HDL Cholesterol 0.6 1.0 2.3 1.5 -1.0 -1.5 0.1 -0.6 0.0
LDL Cholesterol 0.9 1.4 3.8 -1.0 1.2 0.9 1.1 1.9 0.0
Lupus 0.5 0.8 3.2 -1.8 -0.0 0.6 -0.5 1.1 0.0
Neuroticism (2016) 2.9 4.1 9.8 -2.8 1.7 3.1 1.8 0.5 0.9
Primary Biliary Cirrhosis 0.7 1.0 4.4 0.5 0.6 -0.1 0.8 0.7 -2.1
Rheumatoid Arthritis 0.2 0.2 1.1 0.5 0.1 1.0 0.1 -0.2 -0.2
Schizophrenia (2014) 1.2 2.7 11.8 -3.4 0.4 -1.7 -1.2 -0.2 0.0
Triglycerides 0.5 0.9 4.4 -0.4 -0.3 0.7 2.1 0.5 0.0
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.2 1.0 0.3 -1.1 0.1 0.6 0.0
Ulcerative Colitis 0.5 0.8 2.6 -0.6 -0.5 -1.6 -0.1 -1.2 0.0
Blood Eosinophil Count 0.7 5.3 12.4 -3.5 -1.7 1.4 -1.1 -2.2 3.0
Blood Platelet Count 0.6 6.9 30.8 0.5 -3.0 0.6 0.2 -5.5 -1.1
Blood Red Count 1.9 18.2 37.5 -3.1 0.4 1.5 -6.1 -4.8 6.0
Blood White Count 0.5 3.9 12.0 -3.5 1.3 2.6 -0.3 -0.7 1.7
Heel T-Score 0.9 7.2 20.9 2.5 -3.0 -4.6 -1.3 -2.2 0.9
BMI 1.3 7.8 22.1 0.3 1.8 0.8 4.7 0.8 -4.5
Height 0.3 5.8 20.7 -1.0 2.1 -1.4 2.3 4.6 -1.2
Waist Hip Ratio (WHR) 0.5 2.1 6.5 -2.5 2.1 0.7 0.1 0.7 1.1
Systolic Blood Pressure 1.7 8.4 16.6 -1.7 -3.7 -1.7 -1.3 -4.1 3.6
Smoking Status 1.7 4.0 10.7 -1.5 1.7 0.7 3.3 2.1 -1.8
Allergy or Eczema 0.3 0.9 1.7 1.0 -0.9 -1.3 0.2 0.8 -1.0
Cardiovascular Disease 0.6 2.1 2.9 -1.0 -1.6 -1.3 1.2 -1.7 1.7
Hypothyroidism (self reported) 2.6 5.9 13.4 -3.7 1.8 1.7 2.0 2.8 2.1
Respiratory disease 1.6 3.6 8.0 0.4 0.2 -2.6 2.8 2.0 -1.6
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.4 -0.8 -0.2 0.2 1.2 0.5 -0.5
Lung FEV1/FVC ratio 0.4 2.0 9.2 1.5 -0.1 0.4 -3.0 -0.3 0.4
Lung FVC 1.1 5.7 20.3 2.3 -1.0 0.8 -4.5 -2.6 0.3
Neuroticism 0.4 1.0 1.8 -0.4 0.9 1.3 1.1 1.3 -0.5
Chronotype (morning person) 1.2 2.7 6.5 -2.6 0.7 2.3 0.6 -1.5 1.2
Hair Pigment 0.1 2.7 5.1 -1.8 1.4 1.2 2.2 1.8 -1.2
Tanning 0.5 6.6 16.9 3.1 -4.1 0.0 -2.0 -3.0 0.0
Hand grip strength (left) 0.2 0.5 2.7 0.2 -1.7 -0.3 -0.1 0.1 0.5
Number of treatments/medications taken 0.7 1.3 2.8 -0.1 1.4 -1.7 0.7 1.5 -0.3
Average weekly spirits intake 0.8 1.0 3.2 0.2 0.3 -1.1 1.8 0.7 -1.1
Sensitivity / hurt feelings 1.1 1.9 4.4 -1.1 1.0 2.0 2.1 -0.0 -0.9
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.1 0.4 -0.1 -0.2 1.1 -0.8 -0.2
Hearing difficulty/problems: Yes 1.2 1.8 5.2 2.3 -1.4 -0.5 -1.6 0.0 -0.9
Relative age of first facial hair 0.2 0.4 1.3 -1.2 -0.5 0.5 0.4 -0.4 0.3
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.3 -0.0 -0.3 0.2 0.5 1.1 0.1
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.6 -0.1 -0.7 -1.2 0.1 -0.6 0.1
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 0.6 -0.2 -0.3 0.4 0.2 -0.4
Systolic blood pressure, automated reading 0.6 1.9 4.1 -0.8 -2.0 -1.9 0.9 -1.3 0.5
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.7 -1.6 0.6 1.6 0.4 0.5 0.4
Angina 0.7 0.9 2.5 0.1 1.1 0.4 1.1 0.7 -1.6
Medication for hormone replacement therapy 0.4 0.5 1.8 -0.8 -0.3 -0.1 1.3 -0.4 0.4
Vitamin and mineral supplements 1.8 2.4 6.7 0.3 -2.5 -0.6 -0.6 -2.6 1.0
Supplements: Zinc 1.8 1.9 5.4 2.0 -0.9 -2.3 -1.0 0.0 -0.8
Medication: Co-codamol 0.7 0.8 1.7 -1.3 1.1 0.4 1.0 0.9 0.4
Medication: Metformin 0.5 0.7 1.6 -0.5 -0.1 1.1 0.9 0.1 -1.3
Diabetes (father) 0.6 0.7 2.4 1.0 -1.5 -0.5 0.2 0.7 -0.3
Diabetes (mother) 0.1 0.2 0.3 -0.3 0.5 -0.2 0.4 -0.2 -0.6
Severe depression (siblings) 1.0 1.1 3.9 0.5 0.4 0.2 2.0 0.8 -1.3
Pack years adult smoking proportion 3.3 5.0 11.8 -1.5 3.4 1.0 2.2 3.0 -1.1
Impedance of leg (right) 0.4 1.7 4.2 -1.5 -0.4 -2.1 -0.6 -0.1 1.8
Leg fat-free mass (left) 1.0 5.4 11.1 -0.2 2.5 1.4 3.3 1.7 -3.2
Trunk fat percentage 1.3 5.1 14.8 -1.4 2.7 0.5 3.9 0.5 -2.5
Hand grip strength (right) 0.6 1.7 4.3 -0.1 -2.1 -0.7 -1.2 -1.3 1.5
Townsend deprivation index at recruitment 0.1 0.2 0.5 0.6 0.4 -0.4 -0.1 0.2 -0.7
Current tobacco smoking 1.7 2.8 5.6 -1.0 2.1 1.5 2.4 1.1 -1.5
Average weekly fortified wine intake 0.5 0.6 1.5 0.9 -1.2 -1.1 -0.1 0.2 -0.6
Maternal smoking around birth 1.5 2.2 5.0 -2.2 1.1 0.8 0.2 1.5 2.0
Fed-up feelings 0.4 0.8 1.5 -0.6 1.2 1.1 1.1 -0.5 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.8 0.8 -0.3 -0.3 1.4 0.1 -0.9
Relative age voice broke 0.3 0.5 1.5 0.1 -1.2 0.9 -0.3 -0.6 0.1
Taking other prescription medications 1.1 1.7 7.7 0.6 -0.3 -2.8 0.9 1.2 -0.2
Age when periods started (menarche) 1.2 2.9 8.0 0.8 -0.8 -1.4 -2.8 -1.1 2.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 2.3 -0.1 -0.6 0.1 1.5 -0.2 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 3.5 1.6 -1.9 -1.2 -1.4 -1.0 -0.3
Tinnitus: Yes, but not now, but have in the past 3.8 4.1 8.1 1.3 -2.6 -2.8 -2.2 -1.4 1.2
Qualifications: CSEs or equivalent 0.7 0.9 2.0 0.0 1.0 1.4 0.8 0.5 -1.2
Serious illness, injury or assault to yourself 0.3 0.4 1.3 0.8 0.5 0.1 0.4 -0.3 -1.1
High blood pressure 0.8 2.2 3.5 -0.9 -1.2 -1.9 1.2 -1.9 1.5
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.8 1.9 -1.7 -1.6 -0.4 -0.6 -1.0
Multivitamins +/- minerals 1.5 1.9 4.6 -0.1 1.8 0.0 1.4 2.2 -1.3
Stomach or abdominal pain in last month 2.5 3.1 6.0 0.2 2.0 0.2 2.0 2.1 -2.4
Supplements: Glucosamine 0.5 0.6 1.4 1.1 -0.9 -0.4 0.0 0.3 -1.2
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 3.4 0.1 1.8 0.8 0.4 1.3 -0.9
Medication: Atenolol 0.2 0.3 1.0 -1.0 -0.4 -0.8 -0.2 -0.2 0.1
Medication: Levothyroxine sodium 2.0 3.3 8.4 -2.2 1.7 1.6 0.8 2.9 0.9
Sitting height 0.2 1.4 2.9 0.9 -0.3 -0.2 1.7 1.2 -1.7
Chronic bronchitis/emphysema (father) 0.7 0.8 1.6 -0.8 1.2 -0.8 0.2 1.3 0.8
High blood pressure (mother) 0.6 0.8 2.5 -0.1 -0.5 -1.6 0.9 -0.4 -1.0
Body mass index (BMI) 1.5 6.3 17.2 -0.1 2.1 1.1 4.1 0.5 -3.8
Impedance of leg (left) 0.2 1.0 2.2 -1.5 -0.6 -1.4 -0.0 0.2 1.3
Leg predicted mass (left) 1.0 5.4 11.1 -0.3 2.5 1.5 3.3 1.6 -3.2
Trunk fat mass 1.7 7.3 19.9 -1.3 3.1 0.7 4.5 1.5 -3.1
Waist circumference 1.6 5.7 15.1 -0.9 2.4 0.9 3.9 1.2 -3.2
Number of incorrect matches in round 1.7 2.8 10.3 -1.2 0.7 -0.4 -2.0 0.2 3.2
Past tobacco smoking 0.5 0.9 2.4 0.5 -0.3 0.4 -1.3 -1.5 0.9
Alcohol usually taken with meals 0.6 0.9 3.0 0.4 1.7 0.6 -0.1 1.3 -0.6
Nervous feelings 1.1 2.0 4.4 -1.7 0.7 1.0 -2.1 0.3 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 3.6 0.7 0.7 0.8 1.9 -0.1 -1.1
Hearing difficulty/problems with background noise 0.5 0.7 1.9 0.9 -1.4 -0.2 -1.1 -0.6 0.3
Hair/balding pattern: Pattern 2 0.6 0.8 1.8 0.9 -1.3 0.2 -0.7 -1.3 0.1
Had menopause 0.5 0.6 1.2 -1.1 0.1 -0.4 0.5 -1.1 0.8
Had other major operations 0.9 1.2 3.0 -0.4 0.7 -0.6 1.7 0.5 -1.7
Forced vital capacity (FVC) 0.8 3.1 14.0 0.6 0.5 0.5 -3.7 -0.1 1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 4.3 1.7 -2.1 -0.9 -1.0 -1.1 -0.4
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.6 1.4 0.1 -1.9 0.4 0.2 -1.0
Qualifications: None of the above 1.9 4.1 10.3 -3.2 2.6 0.4 0.7 1.6 2.2
Financial difficulties in last 2 years 0.4 0.6 2.0 -0.7 0.1 0.2 1.4 0.3 0.9
Mouth/teeth dental problems 1.0 1.5 3.1 1.8 -1.7 -1.1 -0.5 -0.2 -1.1
Heart attack 0.0 0.1 0.3 0.1 0.0 -0.6 -0.0 0.0 -0.1
Allergy 0.6 1.3 3.5 -1.3 1.0 1.9 -0.6 -0.2 1.0
Pain all over the body in last month 0.6 0.6 1.2 -0.8 1.1 1.0 -0.8 -0.4 -0.1
Diabetes (self-reported) 0.4 0.6 1.6 -0.3 -0.8 0.4 1.3 0.8 -0.8
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.1 1.8 -1.6 -0.9 -1.1 0.4 -0.3
Medication: Ramipril 1.7 2.2 6.6 -2.6 1.1 0.4 1.5 -0.9 1.5
Medication: Simvastatin 0.6 0.8 1.7 -0.2 -1.2 -1.2 1.3 -0.3 -0.1
Fluid intelligence score 1.5 3.1 11.1 3.3 -2.0 -1.1 -0.7 -0.9 -1.0
Illnesses of siblings 0.8 1.2 3.0 -0.9 1.7 1.0 -0.8 1.1 0.6
Neuroticism score 0.5 1.0 2.1 -0.6 0.8 1.5 1.5 0.9 -0.1
Weight 1.6 7.9 20.1 -0.4 2.6 1.0 4.5 1.8 -4.0
Impedance of arm (right) 1.0 4.5 16.6 -1.8 -0.1 -0.5 -2.6 -0.1 4.1
Arm fat percentage (right) 1.0 3.9 11.8 -0.9 2.4 0.7 3.4 0.6 -2.2
Trunk fat-free mass 0.8 4.8 9.5 0.4 1.5 0.7 3.1 2.6 -3.1
Hip circumference 1.6 6.7 19.6 0.9 1.1 0.2 4.3 0.6 -4.4
Time employed in main current job 0.3 0.4 1.0 0.0 0.4 -0.4 -1.0 -0.5 0.9
Alcohol intake versus 10 years previously 0.2 0.4 1.5 -0.1 1.2 -0.4 0.4 -0.2 -0.5
Father’s age at death 0.8 1.1 4.4 2.1 -0.7 0.1 -0.7 0.5 -1.1
Worrier / anxious feelings 0.3 0.6 0.9 -0.8 1.0 0.2 -0.6 0.8 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.4 0.1 0.2 -0.4 0.6 -0.5 0.2
Falls in the last year 1.0 1.4 2.3 1.0 0.1 -1.3 1.5 -0.9 -1.5
Hair/balding pattern: Pattern 3 0.6 0.8 1.9 0.2 -0.9 -1.1 -1.0 -0.1 1.4
Number of live births 3.3 4.6 8.7 -2.5 3.0 1.4 2.4 2.0 -1.0
Forced expiratory volume in 1-second (FEV1) 1.3 4.3 19.5 1.3 0.2 0.9 -4.4 -0.7 1.8
Pulse rate 1.8 3.1 9.2 0.4 -0.3 -0.4 -3.0 -2.1 2.2
Happiness 0.9 1.2 2.4 1.6 -0.4 -1.2 0.9 0.4 -1.3
Noisy workplace 3.3 4.0 6.7 -0.6 2.2 0.3 2.4 2.6 -2.5
Qualifications: A levels/AS levels or equivalent 1.9 4.2 11.7 3.4 -2.0 -1.4 -1.2 1.4 -2.0
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 6.4 -0.7 0.3 -0.5 2.5 1.4 -1.9
Mouth/teeth dental problems: Dentures 0.4 0.6 1.2 -1.1 1.1 0.5 -0.3 -0.0 1.0
Asthma 1.5 2.9 7.3 1.5 -0.7 -2.7 2.0 0.9 -1.6
Medication: Ibuprofen (e.g. Nurofen) 1.7 2.1 8.0 -0.8 2.8 0.9 1.0 1.5 0.0
Medication: Cholesterol lowering 0.4 0.6 2.0 0.2 -0.7 -1.4 -0.2 -0.1 1.1
Depression (self-reported) 0.3 0.4 1.8 1.3 -0.1 -0.5 0.0 0.4 0.1
Medication: Lansoprazole 0.3 0.3 0.9 -0.9 -0.4 -0.1 -0.0 -0.8 0.2
Prospective memory result 2.0 2.5 5.7 -1.7 2.4 -0.2 0.0 2.2 1.2
Lung cancer (father) 0.7 0.8 3.2 -1.0 -0.6 -0.5 -0.2 -0.1 1.8
Illnesses of mother 1.2 1.4 4.6 2.1 -0.8 -1.1 -1.2 -0.8 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 13.1 1.1 -0.5 1.0 -3.6 -1.1 1.3
Pulse wave Arterial Stiffness index 1.5 1.8 7.3 1.6 -0.5 0.3 0.9 0.1 -2.7
Impedance of arm (left) 0.9 4.1 14.3 -1.2 -0.5 -1.0 -2.4 -1.4 3.8
Arm fat mass (right) 1.6 6.8 19.4 -0.6 2.5 1.0 4.4 1.2 -3.5
Trunk predicted mass 0.9 5.1 10.8 0.4 1.5 0.8 3.3 2.6 -3.1
Standing height 0.3 2.7 10.1 -0.6 1.5 -0.3 1.5 3.2 -1.2
Length of working week for main job 2.5 2.8 10.4 -0.5 -0.8 1.4 -0.9 -3.2 1.5
Exposure to tobacco smoke at home 0.6 0.7 1.5 -0.5 -0.7 1.2 0.5 -1.2 0.0
Breastfed as a baby 1.8 2.3 6.6 1.2 0.0 -0.6 0.6 2.2 -2.6
Tense / ‘highly strung’ 0.3 0.5 1.2 -1.1 0.6 0.3 0.5 0.8 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.1 2.7 0.6 0.7 -1.6 0.8 1.0 -1.3
Hair/balding pattern: Pattern 4 0.4 0.9 1.3 -1.0 1.1 0.6 -0.9 1.0 0.9
Birth weight of first child 0.6 1.0 1.6 -0.0 1.3 1.3 -1.3 -0.2 1.2
Peak expiratory flow (PEF) 1.2 2.8 8.4 0.1 1.2 2.9 -2.6 0.3 -0.2
Pulse wave reflection index 2.0 2.5 5.2 2.3 -2.0 -0.5 0.0 -0.6 -2.2
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.6 -0.1 0.8 -0.1 0.3 0.8 -0.2
Loud music exposure frequency 0.4 0.4 1.2 0.1 0.4 -1.1 1.1 -0.4 -0.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.7 4.5 1.1 -0.1 -0.3 1.4 1.5 -2.1
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 3.6 -0.3 -0.4 1.6 0.3 -1.9 1.0
Blood clot in the leg (DVT) 0.5 0.6 1.3 -1.1 0.3 1.0 -0.2 -0.4 1.0
Medication: Paracetamol 4.0 6.6 16.6 -4.1 3.5 2.6 1.6 0.4 1.2
Headache pain in last month 8.3 14.3 31.7 -5.5 5.6 3.6 1.4 2.1 2.1
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 4.9 0.4 1.0 1.8 0.9 1.2 -2.2
Glaucoma (self-reported) 0.6 0.7 2.8 -0.1 0.9 -0.5 1.7 0.4 -0.5
Gout (self-reported) 0.4 0.6 2.6 -1.6 0.0 -0.1 0.3 0.7 0.3
Hypothyroidism/myxoedema (self-reported) 2.8 5.4 12.5 -3.5 1.9 1.8 1.6 2.9 1.5
Medication: Amlodipine 0.4 0.6 2.7 0.5 -0.6 -1.6 -0.0 0.1 0.1
Medication: Ventolin 100micrograms inhaler 2.3 3.0 4.7 2.2 -0.8 -2.2 1.4 1.2 -2.1
Birth weight 0.9 1.9 7.4 -0.1 2.7 1.2 -0.8 1.0 -0.9
Chronic bronchitis/emphysema (mother) 1.2 1.4 4.4 -0.8 0.3 2.1 -0.5 -1.6 0.5
High blood pressure (siblings) 0.7 1.0 2.6 0.9 -1.6 -0.8 0.7 -1.1 -0.2
Forced vital capacity (FVC), Best measure 0.5 1.8 7.4 0.3 0.2 1.1 -2.7 -0.0 1.5
Body fat percentage 1.5 5.8 17.4 -1.2 2.6 0.3 4.2 0.8 -2.9
Leg fat percentage (right) 1.7 6.2 18.5 -0.8 2.3 -0.1 4.3 0.9 -3.5
Arm fat-free mass (right) 1.5 7.7 20.0 0.5 1.6 0.8 4.4 1.9 -4.5
Exposure to tobacco smoke outside home 4.3 5.7 10.1 -2.0 3.2 2.6 3.1 1.7 -0.8
Comparative body size at age 10 0.8 2.2 7.8 2.8 -0.3 -1.5 0.1 -0.2 -1.8
Number of full brothers 0.3 0.3 0.9 0.5 0.7 -0.5 -1.0 0.3 0.3
Worry too long after embarrassment 1.1 1.8 7.0 0.3 0.4 2.6 1.0 0.8 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 3.3 0.5 1.5 0.5 0.7 -0.1 -1.8
Wheeze or whistling in the chest in last year 0.5 0.9 2.3 -0.2 0.1 -0.7 1.5 0.7 -1.4
Number of children fathered 0.6 0.7 2.2 -1.2 0.2 1.5 -0.5 0.3 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.5 -0.0 -0.9 -1.2 -0.6 -1.0 0.6
Age at first live birth 2.1 3.8 9.0 2.6 -3.0 -1.3 -2.0 -1.2 0.1
Pulse wave peak to peak time 1.5 1.8 6.5 -1.7 0.8 -0.3 -0.6 0.4 2.5
Health satisfaction 1.1 1.4 2.0 1.0 1.2 -1.2 1.2 1.2 -1.4
Shortness of breath walking on level ground 1.6 1.9 5.3 2.3 -0.8 -1.3 -0.9 -1.4 -0.9
Qualifications: College or University degree 1.9 5.9 14.4 3.8 -2.9 -1.6 -2.8 -0.4 -1.4
Eye problems/disorders: None of the above 0.8 0.9 3.5 0.2 1.1 0.3 -0.3 1.9 -0.7
Mouth/teeth dental problems: Loose teeth 0.5 0.5 0.8 -0.2 0.9 -0.8 -0.8 0.9 0.5
Emphysema/chronic bronchitis 4.0 4.5 12.2 -2.3 3.5 2.2 1.3 1.7 0.4
Medication for pain relief, constipation, heartburn 3.4 5.8 13.1 3.6 -3.5 -1.5 -1.7 -1.6 -1.0
Neck or shoulder pain in last month 0.7 1.0 1.6 0.3 1.2 0.3 1.2 1.0 -1.3
Medication: Blood pressure 1.1 2.0 6.1 -1.2 -0.4 -1.6 -0.4 -1.1 2.5
Angina (self-reported) 0.7 1.0 2.8 0.2 1.0 0.4 1.2 0.5 -1.7
Migraine (self-reported) 1.6 2.0 4.0 -1.9 2.0 1.1 0.7 1.4 0.7
Medication: Ibuprofen 0.7 0.8 4.0 0.2 2.0 0.3 0.8 0.2 -0.5
Medication: Allopurinol 0.4 0.6 2.0 -1.4 -0.4 -0.8 0.5 0.4 0.6
Medication: Omeprazole 0.2 0.3 0.8 0.2 0.3 0.3 0.2 -0.8 -0.9
Medication: Seretide 50 evohaler 1.0 1.2 4.3 1.4 0.6 -2.1 0.5 -0.0 -0.4
Mean time to correctly identify matches 0.4 0.8 2.1 -0.7 1.3 0.7 1.4 0.4 0.5
Heart disease (mother) 0.4 0.5 1.5 -0.3 -1.0 -0.1 -0.2 1.2 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.4 -0.2 -0.3 0.1 -0.9 -0.7 1.2
Whole body fat mass 1.9 7.8 21.7 -1.0 2.9 0.6 4.7 1.5 -3.6
Leg fat mass (right) 2.2 8.6 22.9 -1.0 3.1 0.4 4.8 1.7 -3.9
Arm predicted mass (right) 1.5 7.6 18.7 0.2 1.9 1.1 4.3 1.9 -4.3
Pulse rate, automated reading 4.5 14.5 29.6 -2.1 0.7 2.6 -5.4 -4.3 5.2
Alcohol intake frequency. 0.3 0.7 2.0 -0.3 1.2 0.1 -1.4 0.4 0.9
Comparative height size at age 10 0.6 3.4 10.7 -1.6 1.7 -0.8 1.8 3.3 -0.5
Number of full sisters 0.9 1.1 4.0 -0.7 0.1 0.6 2.0 -0.4 -1.2
Suffer from ‘nerves’ 0.5 0.7 1.3 0.7 -0.6 -1.1 -0.6 -0.9 1.1
Overall health rating 1.6 3.5 11.5 -1.2 2.2 -0.3 3.4 1.2 -1.4
Chest pain or discomfort 1.3 1.9 4.0 -1.3 2.0 0.3 2.0 1.4 0.2
Had major operations 1.0 1.1 3.3 -1.5 0.6 0.5 0.5 0.4 1.8
Age at last live birth 1.5 2.2 7.2 1.4 -2.7 -0.9 -0.6 -1.5 0.4
Family relationship satisfaction 3.4 4.2 9.4 3.1 -1.1 -1.4 1.1 1.5 -3.0
Leg pain on walking 2.5 3.1 6.0 -1.4 2.1 -0.6 2.4 2.2 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.4 -0.2 0.2 0.9 1.1 0.8 -1.2
Commuting to job workplace: Car/motor vehicle 0.9 1.1 4.6 -0.6 0.8 -0.3 2.2 0.5 -0.7
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.0 1.4 -0.7 -0.3 -1.1 1.2 -0.5
Medication: Aspirin 0.6 0.8 2.4 -0.7 0.4 -1.3 -0.6 0.1 1.5
Supplements: Vitamin C 0.6 0.7 2.5 -1.0 1.6 0.1 0.1 0.3 0.7
Knee pain experienced in last month 0.3 0.5 1.2 0.2 -0.6 -1.1 1.0 -0.7 -0.4
Hypertension (Self-reported) 0.7 2.0 4.6 -0.8 -1.2 -2.1 1.1 -1.4 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.0 -0.0 -1.0 -0.3 0.0 -0.6 -0.8
Illnesses of father: Heart disease 0.4 0.5 1.1 1.0 -0.1 -0.5 0.3 -0.9 -0.8
Illnesses of siblings: Diabetes 0.4 0.5 2.7 0.5 -1.6 0.1 -0.3 0.4 -0.4
Smoking status: Previous 0.7 1.0 2.8 -0.7 0.3 -1.0 1.3 1.7 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.4 3.0 7.7 -0.3 2.1 -0.4 1.6 2.8 -1.7
Whole body fat-free mass 1.0 5.7 12.2 0.2 1.9 1.2 3.5 2.3 -3.5
Leg fat-free mass (right) 0.9 5.0 10.6 0.1 2.0 1.7 3.2 1.5 -3.3
Arm fat percentage (left) 1.0 4.0 12.3 -0.7 2.3 0.7 3.5 0.0 -2.4
Average weekly red wine intake 0.6 0.9 1.6 0.8 -0.6 -1.3 -1.0 1.2 0.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 -0.5 -0.3 0.3 0.8 0.1 0.4
Mood swings 0.6 1.1 5.5 -0.4 0.6 0.0 2.4 -0.2 0.6
Loneliness, isolation 1.3 1.8 3.1 -1.6 1.4 1.5 1.8 -0.5 0.7
Long-standing illness, disability or infirmity 0.3 0.4 1.6 -0.1 0.7 -0.5 1.3 0.2 -0.3
Ever had bowel cancer screening 0.7 0.8 1.9 -0.9 0.1 -0.7 -0.5 1.4 1.1
Diabetes diagnosed by doctor 0.9 1.5 3.7 -1.2 -0.1 1.2 1.9 1.2 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.6 -1.5 0.8 1.4 -1.6 -0.9 1.0
Friendships satisfaction 2.0 2.5 5.8 1.4 -0.3 0.0 2.1 1.6 -2.4
Qualifications: nursing, teaching 0.7 1.0 3.7 1.4 -0.2 -0.0 0.1 0.7 -1.9
Commuting to job workplace: Walk 0.6 0.7 2.3 -0.6 0.7 -0.4 -0.7 0.1 1.5
Eye problems/disorders: Cataract 2.0 2.3 5.2 1.4 -2.3 -0.9 -1.2 -2.1 0.4
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.6 -0.9 1.0 0.3 1.6 1.0 -0.6
Medication for cholesterol 0.8 1.1 2.6 0.1 0.9 1.4 -1.6 -0.4 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.6 3.4 -1.5 1.9 1.0 1.2 1.1 -0.3
Back pain experienced in last month 0.5 0.8 1.6 -1.3 1.2 0.3 0.3 -1.1 0.6
Mineral and other dietary supplements 0.7 0.9 3.1 -1.2 -0.3 -0.2 -0.1 -0.8 1.8
Breast cancer (self-reported) 0.2 0.3 1.1 0.3 -1.1 -0.5 -0.2 0.2 0.1
Asthma (self-reported) 1.4 2.9 8.3 1.4 -0.6 -2.9 1.9 0.9 -1.4
Osteoporosis (self-reported) 0.2 0.3 0.5 0.4 -0.2 -0.6 -0.7 0.7 0.3
Osteoarthritis (self-reported) 1.5 1.9 4.8 1.9 -2.2 -1.7 -0.4 -0.2 0.0
Medication: Aspirin 0.6 0.8 2.0 -0.4 0.2 -1.4 -0.8 0.3 1.3
Medication: Gliclazide 1.7 1.9 4.8 1.0 -0.7 -1.1 1.5 1.3 -2.2
Illnesses of father: None of the above (group 1) 0.3 0.3 1.3 0.5 -0.0 -0.4 -0.0 1.1 -0.6
Smoking status: Current 2.0 3.2 6.1 -1.3 2.1 1.9 2.5 1.0 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 14.9 0.8 0.2 1.4 -3.9 -0.9 1.5
Whole body water mass 0.9 5.1 11.6 0.4 1.7 1.0 3.2 2.2 -3.4
Leg predicted mass (right) 0.9 4.9 10.7 0.2 1.9 1.6 3.2 1.5 -3.3
Arm fat mass (left) 1.6 6.5 18.9 -0.6 2.5 1.0 4.3 1.0 -3.4
Number of self-reported non-cancer illnesses 0.9 1.6 5.3 0.2 -0.9 -2.3 1.0 1.6 0.4
Average weekly champagne plus white wine intake 0.2 0.2 0.5 0.3 0.3 0.6 0.3 -0.4 -0.7
Miserableness 1.1 1.9 4.6 -1.4 1.0 1.5 2.1 1.2 0.1
Guilty feelings 1.1 1.6 4.2 -0.6 1.2 0.9 1.7 2.0 -0.2
Wears glasses or contact lenses 0.5 0.6 1.6 0.8 0.0 -1.3 -1.1 0.1 0.1
Ever taken oral contraceptive pill 1.5 1.7 3.1 1.8 -1.6 -1.0 -0.1 -1.6 -0.9
Hearing aid user 1.7 1.9 8.1 1.4 0.8 0.2 0.9 -0.1 -2.8
Mother’s age at death 1.2 1.6 3.9 2.0 -1.0 -0.2 -1.9 -0.9 -0.2
Financial situation satisfaction 0.3 0.3 1.0 0.8 0.1 -1.0 -0.3 0.1 0.3
Tinnitus: Yes, now most or all of the time 1.6 1.8 5.8 2.4 -0.9 -0.6 -1.8 -0.5 -0.6
Commuting to job workplace: Public transport 0.2 0.3 0.7 0.4 -0.4 0.7 -0.8 -0.3 0.0
Eye problems/disorders: Glaucoma 0.8 0.9 4.2 -0.1 0.8 -0.4 2.1 0.5 -0.5
Medication: Blood pressure 0.6 1.1 3.9 0.0 -1.1 -2.0 0.8 -0.7 -0.2
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.1 -0.5 -0.5 -1.0 1.0 0.3 0.1
Supplements: Fish oil (including cod liver oil) 0.6 0.7 2.6 1.2 -0.3 -0.1 -0.1 0.6 -1.6
High cholesterol (Self-reported) 0.4 0.6 1.1 0.5 -0.8 -1.0 1.1 0.9 -0.0
Medication: Bendroflumethiazide 1.3 1.9 6.7 1.0 -1.7 -2.6 -0.3 -0.9 0.2
Medication: Paracetamol 2.6 4.0 10.3 -3.2 2.7 2.0 0.9 -0.2 1.1
Medication: Lisinopril 0.7 0.9 2.8 0.9 0.0 -1.7 -0.4 -0.9 0.8
Medication: Atorvastatin 0.4 0.5 1.5 -0.2 0.4 -1.2 -0.9 0.6 0.7
Illnesses of father: High blood pressure 0.5 0.7 2.9 -0.9 0.2 1.7 0.4 -0.4 0.0
Alcohol drinker status: Never 1.6 1.9 3.5 -1.5 1.9 1.9 -0.5 1.4 -0.2
Ever smoked 0.9 1.6 3.6 1.1 -0.3 -1.3 1.2 1.2 -1.9
Basal metabolic rate 1.1 6.3 14.6 0.1 2.0 1.1 3.8 2.1 -3.7
Leg fat percentage (left) 2.0 7.1 21.3 -0.7 2.1 0.2 4.6 1.2 -3.8
Arm fat-free mass (left) 1.5 7.6 18.3 0.1 1.9 0.9 4.3 2.5 -4.1
Number of operations (self-reported) 0.8 1.2 2.5 -0.9 1.6 -0.3 1.4 1.2 0.4
Average weekly beer plus cider intake 3.7 5.4 11.1 -3.0 2.7 2.2 3.3 -0.1 -0.6
Irritability 0.4 0.7 1.3 0.9 -0.3 0.7 0.9 1.0 -1.1
Risk taking 1.8 2.6 5.2 2.3 -1.7 -1.0 1.5 -1.5 -1.5
Ever had prostate specific antigen (PSA) test 1.6 1.8 6.1 1.1 -1.7 -0.6 -2.5 0.0 0.4
Fractured/broken bones in last 5 years 1.8 2.3 7.8 1.9 -0.3 0.5 1.4 0.4 -2.8
Age started oral contraceptive pill 0.3 0.3 0.9 0.4 -0.5 -0.2 0.4 -0.9 -0.8
Diastolic blood pressure, automated reading 2.9 8.9 15.0 -0.3 -3.1 -2.0 -3.6 -3.9 3.4
Ever depressed for a whole week 0.5 0.7 1.7 0.0 1.3 -1.1 0.2 1.0 -0.5
Unable to work because of sickness or disability 0.4 0.5 2.1 -0.0 1.0 0.4 1.4 0.0 -0.4
Commuting to job workplace: Cycle 1.5 1.8 4.7 2.2 -1.2 -0.6 -0.3 0.6 -1.9
Myopia 0.4 0.6 2.3 0.4 -0.3 0.0 -1.5 -0.5 0.9
Vascular/heart problems diagnosed by doctor 0.6 1.8 2.2 1.4 0.9 1.5 -1.3 1.3 -1.4
Cholesterol lowering medication 0.9 1.4 4.4 -0.4 0.3 0.3 2.1 0.5 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 1.0 -0.2 0.0 0.2 -0.0 -1.0 -0.5
Pain experienced in last month 1.9 3.2 6.4 2.3 -2.5 -1.5 -1.8 -1.4 0.0
Supplements: Calcium 1.4 1.5 3.2 -1.0 1.3 1.8 -0.0 1.0 -1.4
Basal cell carcinoma (self-reported) 0.4 0.5 1.5 0.2 0.8 -0.2 -1.2 -0.5 0.7
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.4 0.2 -0.1 -0.6 -0.0 0.2 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.5 -1.2 0.6 0.9 -0.1 -0.3 1.0
Heart disease (siblings) 2.6 3.2 6.9 2.2 -2.0 -2.6 -1.6 -1.0 -0.2
Alcohol drinker status: Previous 2.4 2.8 6.8 -0.6 1.0 -2.6 -1.5 -0.3 2.4
Pack years of smoking 4.2 6.2 13.7 -1.7 3.6 1.1 2.3 3.7 -1.1
Impedance of whole body 0.5 2.7 8.7 -1.7 -0.5 -1.3 -1.4 -0.6 2.9
Leg fat mass (left) 2.5 9.7 25.3 -0.9 3.1 0.8 5.0 1.9 -4.3
Arm predicted mass (left) 1.6 8.1 18.8 0.0 2.0 0.9 4.3 2.5 -4.3