TWAS hub - ANAPC7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0860	0.0370	4.1e-05	0.016	0.045	0.030	0.045	0.023	0.0044	3.3e-06	1.4e-04	3.4e-06	0.00065
2	GTEx	Adipose Visceral Omentum	0.3130	0.0980	3.7e-03	-0.005	NA	0.014	NA	-0.005	0.8600	NA	6.2e-02	NA	0.85000
3	GTEx	Cells Transformed fibroblasts	0.1790	0.0660	7.2e-04	0.023	NA	0.018	NA	0.025	0.0067	NA	1.6e-02	NA	0.00510
4	GTEx	Muscle Skeletal	0.0756	0.0496	4.5e-03	0.007	NA	0.000	NA	0.004	0.0630	NA	3.1e-01	NA	0.11000
5	YFS	Blood	0.0174	0.0084	2.3e-05	0.007	0.011	0.010	0.011	0.010	0.0018	8.0e-05	1.9e-04	1.1e-04	0.00022
6	TCGA	Brain Lower Grade Glioma	0.1600	0.0563	1.7e-05	0.010	0.042	0.060	NA	0.034	0.0220	1.2e-05	2.1e-07	NA	0.00008
7	TCGA	Lung Squamous Cell Carcinoma	0.0311	0.0176	1.3e-03	0.021	0.019	0.003	NA	0.008	0.0018	2.6e-03	1.4e-01	NA	0.04000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Headache pain in last month	8.1	13.9	29.6	-5.4	-0.2	-1.2	-1.0	-5.2	-3.9	-4.9
Hearing aid user	5.4	6.1	11.4	2.2	0.9	3.4	1.9	2.0	3.2	2.7
Schizophrenia vs Biploar Disorder	5.1	6.7	22.5	-1.2	1.6	-2.5	-4.7	-2.0	-1.0	-3.1
Family relationship satisfaction	5.1	6.3	11.8	2.8	-0.9	2.2	2.9	2.8	1.5	3.4
Schizophrenia (2018)	4.5	9.4	20.7	-2.6	-0.2	-2.9	-3.8	-3.9	0.0	-4.6
Schizophrenia (2014)	4.3	9.6	21.8	-2.6	-0.8	-2.4	-4.2	-3.8	0.0	-4.7
Pulse rate, automated reading	3.7	12.0	41.3	-3.2	1.7	1.4	-6.4	-3.2	0.3	-4.1
Risk taking	3.7	5.4	12.5	2.0	0.6	0.7	2.8	3.1	1.9	3.5
Hypothyroidism (self reported)	3.5	8.0	15.9	-0.4	2.3	-3.3	-0.6	-3.6	-4.0	-3.3
Hip circumference	3.5	14.9	32.5	3.2	-0.7	3.8	5.7	3.7	3.3	4.8
Hypothyroidism/myxoedema (self-reported)	3.3	6.5	12.9	-0.4	2.3	-1.9	-0.7	-3.4	-3.6	-3.3
Body Mass Index (BMI) (2010)	3.2	4.4	16.8	2.3	-1.8	2.0	4.1	1.4	0.0	0.0
Number of incorrect matches in round	3.2	5.4	10.8	-2.5	1.3	-1.6	-3.1	-2.2	-1.3	-3.3
Serious illness, injury or assault of a close relative in last 2 years	3.1	3.6	7.2	2.5	-0.9	2.1	2.7	-0.2	2.1	1.3
Leg fat percentage (left)	3.1	11.4	21.9	3.5	-0.9	4.5	4.7	1.8	3.4	3.1
Pulse wave peak to peak time	3.0	3.5	6.1	-2.3	-0.2	-1.4	-1.6	-2.3	-1.9	-2.5
Intelligence (Savage-Jansen 2018)	2.9	8.8	18.1	3.2	2.1	1.1	3.1	4.2	0.4	4.3
Leg fat mass (left)	2.9	11.3	31.6	2.2	-1.4	4.5	5.6	2.0	2.3	3.3
Medication: Levothyroxine sodium	2.8	4.7	15.0	-0.6	2.1	-1.2	-0.7	-2.1	-3.9	-2.7
Pulse wave Arterial Stiffness index	2.8	3.3	5.8	2.1	0.1	1.4	1.9	2.2	1.6	2.4
Pulse wave reflection index	2.8	3.5	8.0	1.5	0.1	1.0	2.0	2.5	1.6	2.8
Leg fat percentage (right)	2.8	10.2	18.1	3.3	-1.3	4.3	4.2	1.7	3.4	2.9
Fractured/broken bones in last 5 years	2.8	3.6	8.1	1.1	0.1	0.5	2.8	2.6	0.9	2.9
Body mass index (BMI)	2.7	11.7	23.1	2.7	-1.1	4.6	4.8	2.8	2.9	3.6
Comparative body size at age 10	2.7	7.5	15.1	2.8	-0.3	1.8	2.1	3.8	2.7	3.9
Leg fat mass (right)	2.6	10.1	27.2	2.1	-1.9	4.2	5.2	1.9	2.2	3.1
BMI	2.5	14.5	35.6	2.7	-1.4	3.9	6.0	3.6	2.9	4.4
Medication: Ventolin 100micrograms inhaler	2.5	3.2	8.0	1.8	-0.1	-0.7	2.1	2.8	-0.1	2.4
Friendships satisfaction	2.5	3.1	7.3	1.8	-0.9	1.0	2.7	1.5	1.1	2.4
Arm fat mass (right)	2.4	9.7	23.5	2.4	-1.4	4.2	4.8	2.2	2.1	3.1
Medication: Gliclazide	2.4	2.7	6.9	2.6	-0.2	0.7	2.2	1.5	0.7	2.0
Arm fat mass (left)	2.4	9.8	22.6	2.5	-1.2	4.3	4.8	2.2	2.2	3.2
Alcohol drinker status: Previous	2.4	2.8	6.2	-1.9	-0.6	-1.6	-2.5	-0.7	-1.7	-1.8
Stomach or abdominal pain in last month	2.3	2.9	9.0	1.0	0.2	3.0	2.6	1.0	0.6	1.5
Nervous feelings	2.3	4.3	10.2	-0.9	-0.6	0.8	-2.9	-3.1	-0.5	-3.2
Shortness of breath walking on level ground	2.3	2.7	9.3	0.7	0.9	0.2	0.5	3.0	1.5	2.4
Whole body fat mass	2.3	9.6	24.4	2.3	-1.4	4.3	4.9	1.8	2.3	2.9
Verbal and Numeric Reasoning (VNR)	2.2	5.4	18.8	1.8	0.7	0.7	1.3	4.3	0.2	3.6
Qualifications: None of the above	2.2	4.7	12.1	-2.2	-0.8	-1.0	-1.6	-3.5	-1.1	-3.2
Coronary Artery Disease (CAD)	2.1	2.5	7.8	0.6	2.1	-1.1	-2.0	-2.8	0.0	0.0
Body fat percentage	2.1	8.4	17.8	2.9	-1.4	4.2	3.9	1.3	2.8	2.4
Had major operations	2.1	2.5	5.0	-1.5	0.7	-2.0	-1.1	-1.5	-2.2	-1.6
Supplements: Calcium	2.1	2.3	9.9	-0.0	-1.9	3.1	0.4	-0.8	1.4	-0.2
Major Depression (MDD)	2.0	2.5	7.0	-1.8	0.3	-2.6	1.1	-0.8	-2.1	-0.5
Blood Red Count	2.0	19.0	73.8	-2.6	-0.4	-2.1	-8.6	-3.8	0.1	-5.8
Waist circumference	2.0	7.3	15.9	2.3	-1.5	4.0	3.8	1.4	2.3	2.4
Weight	2.0	9.7	29.0	1.7	-1.1	4.0	5.4	2.3	1.6	3.3
Noisy workplace	2.0	2.5	10.6	0.8	-0.5	2.1	3.3	0.3	0.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	12.5	-3.5	1.5	-0.6	-3.0	-0.1	-2.0	-1.5
Maternal smoking around birth	1.9	2.8	6.2	-1.7	0.0	-0.7	-1.4	-2.5	-1.6	-2.3
Impedance of arm (right)	1.9	8.9	23.0	-1.4	-0.7	-2.0	-4.8	-3.5	-1.9	-4.1
Falls in the last year	1.9	2.6	5.1	0.3	-1.7	0.1	2.1	2.2	1.0	2.2
Arm fat percentage (left)	1.9	7.5	15.7	2.6	-1.2	4.0	3.5	1.8	2.6	2.5
Trunk fat mass	1.8	7.6	20.5	2.0	-1.3	3.9	4.5	1.3	1.9	2.4
Asthma	1.8	3.5	6.8	2.6	-1.5	-0.4	2.0	2.3	0.5	2.4
Medication: Lansoprazole	1.8	2.0	5.4	2.0	-1.4	1.1	-0.6	-1.0	2.3	-0.4
Prospective memory result	1.8	2.2	4.0	-2.0	0.4	-0.3	-1.0	-1.9	-1.6	-2.0
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.7	2.3	-0.2	1.2	2.4	1.7	0.4	2.1
Arm fat-free mass (right)	1.8	9.3	36.0	0.9	-0.4	2.7	6.0	2.6	1.0	3.7
Trunk fat percentage	1.7	6.7	14.8	2.5	-1.3	3.9	3.5	1.1	2.4	2.1
Fluid intelligence score	1.7	3.6	10.6	2.1	1.2	-0.0	0.9	3.2	0.3	2.9
Medication: Paracetamol	1.7	2.9	8.5	-1.6	-0.7	0.3	-0.2	-2.9	-1.5	-2.5
Exposure to tobacco smoke outside home	1.7	2.3	7.5	-0.5	2.4	1.1	2.7	-1.1	-0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	5.3	-0.6	-1.6	0.3	2.3	1.2	1.6	1.8
Arm predicted mass (right)	1.7	8.8	34.5	0.8	-0.5	2.8	5.9	2.3	1.0	3.5
Overall health rating	1.7	3.6	8.7	1.5	-2.3	2.9	2.7	0.2	0.7	1.1
Asthma (self-reported)	1.7	3.4	6.3	2.5	-1.7	-0.4	1.9	2.2	0.5	2.4
Cholesterol lowering medication	1.7	2.5	7.0	2.6	1.4	0.7	1.8	0.3	1.8	1.2
Pack years of smoking	1.7	2.4	4.7	-2.2	-1.9	1.5	2.1	-0.7	-1.1	0.1
Bipolar Disorder or Schizophrenia	1.6	3.9	7.7	-1.8	-1.2	-0.8	-1.7	-2.8	-2.0	-2.8
Severe depression (siblings)	1.6	1.8	6.6	0.2	-0.8	0.5	2.6	1.2	-0.5	1.9
Current tobacco smoking	1.6	2.7	8.4	0.2	-0.6	2.5	2.9	-0.1	1.5	1.1
Medication: Ramipril	1.6	2.0	4.7	-1.1	0.2	-2.2	-0.6	-2.1	1.0	-1.6
Arm fat percentage (right)	1.6	6.4	14.9	2.4	-1.4	3.9	3.2	1.4	2.1	2.2
Age at last live birth	1.6	2.3	12.5	0.2	-0.6	-3.5	-0.4	1.2	-1.0	0.7
Arm fat-free mass (left)	1.6	8.1	31.6	1.0	-0.5	2.9	5.6	2.1	0.8	3.2
Arm predicted mass (left)	1.6	8.1	32.2	0.9	-0.5	2.7	5.7	2.2	0.9	3.2
Worry (Nagel 2018)	1.5	3.1	6.4	-1.8	-0.2	-1.3	-1.9	-2.5	-0.9	-2.5
Crohns Disease (2012)	1.5	2.4	5.5	1.7	0.6	-0.4	0.6	2.4	1.7	2.1
Neuroticism (2016)	1.5	2.2	9.5	-1.3	-0.0	0.5	0.6	-3.1	-0.9	-1.6
Pack years adult smoking proportion	1.5	2.3	5.0	-2.2	-2.2	1.0	2.0	-0.6	-1.1	0.2
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	15.1	-3.9	0.8	-1.2	-3.2	0.0	-2.5	-1.5
Birth weight	1.5	3.3	10.8	-3.3	-2.3	2.4	0.7	-0.6	-0.8	-0.6
Medication: Paracetamol	1.5	2.2	5.8	-1.6	-0.5	-0.2	-0.7	-2.4	-1.2	-2.3
Depression (Nagel 2018)	1.4	2.1	4.8	0.5	-0.8	-0.2	2.2	1.8	-0.8	2.1
Crohns Disease (2017)	1.4	3.2	7.2	2.3	-0.8	-0.4	1.4	2.7	1.0	2.4
Blood Eosinophil Count	1.4	11.1	19.9	3.4	1.1	-3.5	-4.5	-3.7	-1.3	-4.2
Systolic Blood Pressure	1.4	6.8	17.5	3.1	-0.5	-2.2	-4.2	-2.2	2.2	-2.5
Illnesses of siblings	1.4	2.0	4.8	-2.2	1.9	0.4	-0.3	-0.5	-1.9	-1.0
Father’s age at death	1.4	1.8	3.7	1.0	1.7	0.4	1.3	1.9	-0.7	1.7
Qualifications: A levels/AS levels or equivalent	1.4	3.1	8.2	1.6	-0.1	0.0	1.8	2.9	-0.9	2.6
Emphysema/chronic bronchitis	1.4	1.6	3.7	-1.9	0.5	0.9	0.3	-1.8	-0.8	-1.5
Medication for pain relief, constipation, heartburn	1.4	2.4	7.9	1.5	0.6	-0.7	0.2	2.8	1.1	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.4	-1.5	-0.9	-1.6	-1.5	-1.1	-1.0	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	7.7	1.1	-0.0	2.8	1.4	-0.2	0.8	0.7
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	9.5	0.8	3.1	-0.6	0.1	1.1	0.1	0.5
Smoking status: Current	1.4	2.2	8.2	-0.2	-0.6	2.2	2.9	-0.4	1.1	0.9
Supplements: Zinc	1.3	1.4	3.7	-0.4	-1.9	-1.0	0.4	1.5	-0.9	1.2
Happiness	1.3	1.6	3.2	0.4	-1.2	0.5	1.8	1.7	-0.1	1.7
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	5.7	-2.4	-0.7	2.0	0.8	0.1	-0.6	0.1
Age at first live birth	1.3	2.4	9.4	-0.5	-0.7	-3.1	-0.9	1.9	-1.2	0.9
Medication: Seretide 50 evohaler	1.3	1.5	3.5	0.4	0.5	-1.1	1.3	1.8	0.4	1.9
Medication: Aspirin	1.3	1.7	2.9	-1.5	-0.6	-1.7	-1.4	-1.2	-1.1	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.8	-0.4	-0.9	0.4	-2.0	-1.2	1.1	-1.5
Medication for cholesterol	1.3	2.0	7.4	-2.7	0.0	0.5	-1.3	-0.4	-2.0	-0.9
Ever taken oral contraceptive pill	1.3	1.5	3.7	1.7	-0.5	0.1	0.8	1.5	0.7	1.9
Mother’s age at death	1.3	1.6	7.6	-0.2	2.8	1.1	-0.3	1.2	0.5	0.9
Illnesses of father: High blood pressure	1.3	1.7	4.0	1.6	0.3	2.0	-0.5	-0.9	1.9	-0.7
Ever smoked	1.3	2.3	4.5	2.1	-0.4	0.9	2.1	1.5	0.6	1.9
Basal metabolic rate	1.3	7.2	28.1	0.4	-0.9	2.6	5.3	2.3	0.2	3.0
Diastolic blood pressure, automated reading	1.3	4.0	17.9	1.3	-0.4	-2.4	-4.2	-0.1	0.6	-1.4
Ever depressed for a whole week	1.3	1.6	9.3	-1.3	-3.0	0.4	0.6	0.2	0.0	0.1
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.2	-1.6	1.2	-1.6	-0.3	-0.8	-2.0	-0.8
Bipolar Disorder (2018)	1.2	1.9	5.3	0.4	-1.8	2.3	2.0	0.4	-0.1	0.8
Primary Biliary Cirrhosis	1.2	1.7	3.5	1.2	-0.8	1.9	1.7	0.9	0.8	1.3
Blood Platelet Count	1.2	13.8	57.2	7.6	1.6	-1.6	-1.9	1.6	5.2	1.3
Qualifications: CSEs or equivalent	1.2	1.6	8.1	1.3	-0.1	2.8	0.9	0.4	0.6	0.5
Forced vital capacity (FVC)	1.2	4.8	14.0	-3.7	0.2	-1.6	-2.7	-0.5	-2.6	-1.6
Pulse rate	1.2	2.0	11.2	0.2	0.7	0.7	-3.3	-0.2	0.3	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	8.9	-3.0	1.4	-1.4	-2.7	0.1	-2.2	-1.3
Impedance of arm (left)	1.2	5.7	18.0	-0.7	-0.2	-2.0	-4.2	-2.5	-1.0	-3.1
Number of children fathered	1.2	1.4	2.6	-1.3	0.6	-0.8	-0.9	-1.6	-1.0	-1.6
Health satisfaction	1.2	1.6	3.6	0.4	-0.4	1.9	1.8	1.3	-0.0	1.5
Number of full sisters	1.2	1.4	3.5	0.9	-1.8	0.4	1.9	0.1	1.2	1.0
Qualifications: nursing, teaching	1.2	1.9	4.3	1.5	0.1	0.9	1.6	1.4	1.2	2.1
Average weekly champagne plus white wine intake	1.2	1.7	4.6	1.3	-0.4	2.1	0.6	0.4	2.1	0.7
Ovarian Cancer	1.1	1.5	5.1	-1.4	-0.7	-1.1	-0.1	-1.0	-2.2	-0.8
Smoking Status	1.1	2.7	9.6	1.5	-0.8	2.1	3.1	-0.2	1.1	1.0
Average weekly spirits intake	1.1	1.3	3.4	1.4	-1.2	0.8	1.8	0.5	0.0	1.2
Hearing difficulty/problems: Yes	1.1	1.6	5.7	1.4	-0.7	2.4	-0.6	1.4	-0.0	1.0
Systolic blood pressure, automated reading	1.1	3.1	14.9	3.9	-0.8	-0.1	-0.6	-0.2	2.4	0.1
Leg fat-free mass (left)	1.1	5.8	21.8	-0.3	-1.5	2.4	4.7	2.1	-0.2	2.5
Supplements: Glucosamine	1.1	1.5	3.9	1.4	-2.0	1.0	0.4	0.9	0.9	1.2
Leg predicted mass (left)	1.1	5.6	21.7	-0.4	-1.4	2.3	4.7	2.0	-0.3	2.5
Had other major operations	1.1	1.4	3.0	0.8	-0.9	0.4	1.7	0.9	1.5	1.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.4	0.3	-1.1	1.0	1.3	1.3	1.1	1.6
Mouth/teeth dental problems	1.1	1.7	4.0	0.7	-0.3	-1.6	0.8	1.5	1.4	2.0
Breastfed as a baby	1.1	1.3	4.7	-0.0	-0.5	-0.3	2.2	1.1	-1.1	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	5.0	-0.5	-2.2	-1.5	1.4	0.8	-0.3	1.2
Peak expiratory flow (PEF)	1.1	2.6	7.7	-2.8	1.0	1.1	-2.0	-0.8	-0.9	-1.7
Blood clot in the leg (DVT)	1.1	1.4	3.7	-1.3	1.1	-1.3	-0.3	-0.8	-1.9	-0.7
High blood pressure (siblings)	1.1	1.6	5.8	2.4	-1.0	0.0	-0.1	0.4	2.1	0.6
Medication: Ibuprofen	1.1	1.3	3.8	-1.5	-0.3	1.9	0.9	1.1	0.5	1.0
Whole body fat-free mass	1.1	6.2	25.3	-0.1	-0.8	2.2	5.0	2.1	-0.2	2.8
Leg fat-free mass (right)	1.1	6.0	23.0	-0.2	-1.1	2.2	4.8	2.2	-0.3	2.7
Medication: Aspirin	1.1	1.4	2.9	-1.4	-0.6	-1.7	-1.3	-1.0	-1.0	-1.0
Leg predicted mass (right)	1.1	6.0	22.8	-0.2	-1.0	2.3	4.8	2.3	-0.4	2.7
Medication: Bendroflumethiazide	1.1	1.7	3.9	2.0	-0.3	-2.0	-0.1	1.4	0.7	1.2
Commuting to job workplace: Cycle	1.1	1.3	2.8	0.8	-1.4	-0.3	1.1	1.7	-0.9	1.4
Alzheimer’s Disease (in father)	1.0	1.1	3.1	1.0	-0.7	0.1	1.8	0.9	0.9	1.2
Irritable Bowel Disease (IBD)	1.0	2.5	5.8	1.5	-2.4	-1.3	0.8	1.9	1.0	1.5
Respiratory disease	1.0	2.3	4.8	2.1	-1.2	-0.8	2.2	1.3	-0.0	1.7
Medication: Co-codamol	1.0	1.1	3.2	-0.6	-1.1	1.8	0.0	-1.4	-0.5	-0.9
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.0	-0.1	-0.3	-1.4	-1.7	0.3	-1.1	-0.9
Chronic bronchitis/emphysema (father)	1.0	1.1	3.5	-1.0	0.7	-1.5	-0.3	-0.1	-1.9	-0.8
Worrier / anxious feelings	1.0	1.8	4.0	-2.0	0.7	-1.4	-0.3	-1.3	-1.6	-1.4
Lung cancer (father)	1.0	1.1	3.3	-0.7	0.1	-1.3	-0.6	-1.0	-1.8	-1.0
Forced vital capacity (FVC), Best measure	1.0	3.8	7.9	-2.8	1.0	-1.4	-2.2	-0.6	-2.7	-1.6
Illnesses of father: Heart disease	1.0	1.4	3.1	1.3	0.5	-0.8	0.5	1.5	1.8	1.3
Mineral and other dietary supplements	1.0	1.3	2.3	-0.6	1.3	-1.5	-1.0	-1.0	-1.1	-1.3
Whole body water mass	1.0	5.9	24.0	-0.2	-0.8	2.0	4.9	2.1	-0.3	2.8
Heart disease (siblings)	1.0	1.3	4.9	0.5	-2.2	-0.9	-0.9	1.2	0.5	0.7
Impedance of whole body	1.0	5.2	13.3	0.0	-0.1	-1.9	-3.7	-3.1	-0.1	-3.1
HbA1C	0.9	1.0	2.8	-1.3	0.1	-1.7	-1.3	-0.7	0.0	0.0
Lupus	0.9	1.4	5.7	0.6	0.3	-0.2	-1.0	-2.4	-0.2	-1.7
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.0	-0.6	0.9	0.0	-0.4	-1.4	-1.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.7	-0.0	-1.0	-0.7	1.6	1.1	-1.2	1.4
High blood pressure	0.9	2.4	8.6	2.9	-0.4	-1.7	-0.7	-0.4	2.1	-0.1
Financial difficulties in last 2 years	0.9	1.3	3.3	-0.1	-1.8	0.2	-0.1	-1.2	-1.8	-0.8
Trunk predicted mass	0.9	5.0	22.0	-0.2	-0.5	1.7	4.7	1.8	-0.4	2.6
Medication: Blood pressure	0.9	1.5	3.8	-0.2	-0.5	-1.6	-1.9	-1.5	-0.1	-1.3
Ever had bowel cancer screening	0.9	1.1	2.6	-0.9	0.4	-0.3	-0.5	-1.6	-1.2	-1.4
Tinnitus: Yes, now most or all of the time	0.9	1.0	4.4	-0.6	0.0	0.4	-0.1	2.1	-0.9	1.2
Alcohol drinker status: Never	0.9	1.1	2.5	-1.6	1.4	0.3	-0.1	-1.3	-0.1	-1.2
Irritability	0.9	1.5	5.6	0.8	-0.3	2.4	1.8	0.4	0.4	0.9
Depressed Affect (Nagel 2018)	0.8	1.7	6.9	-0.7	-1.4	0.8	2.6	-0.3	-1.3	0.7
Alzheimer’s Disease (in mother)	0.8	0.9	1.9	-0.9	0.9	-0.9	-0.4	-1.4	-0.7	-1.2
Triglycerides	0.8	1.4	6.8	2.6	-0.1	0.7	1.5	-0.1	0.0	0.0
Cardiovascular Disease	0.8	2.6	9.4	3.1	0.5	-1.3	-0.5	-0.4	2.5	-0.0
Age when periods started (menarche)	0.8	1.9	8.9	-0.4	-1.2	0.3	-3.0	0.1	-1.1	-1.3
Multivitamins +/- minerals	0.8	1.0	4.9	-0.5	-0.4	0.3	2.2	0.6	-0.5	0.9
High blood pressure (mother)	0.8	1.1	3.0	1.7	-1.1	-0.3	0.8	0.5	1.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.7	0.5	-0.5	0.5	2.2	1.0	0.4	1.4
Trunk fat-free mass	0.8	4.8	20.8	-0.3	-0.5	1.7	4.6	1.8	-0.5	2.5
Mouth/teeth dental problems: Dentures	0.8	1.3	2.4	-1.4	0.8	1.0	-1.0	-0.9	-1.1	-1.6
Number of full brothers	0.8	1.1	5.1	-2.3	-0.9	-0.8	-0.6	0.1	-0.4	-0.6
Worry too long after embarrassment	0.8	1.3	3.3	1.0	1.5	1.5	1.8	-0.3	-0.1	0.5
Qualifications: College or University degree	0.8	2.4	9.2	1.5	0.2	-0.3	0.0	3.0	0.0	2.3
Migraine (self-reported)	0.8	1.0	2.4	-0.9	0.0	1.1	-0.3	-1.3	-1.1	-1.6
Medication: Allopurinol	0.8	1.1	3.5	0.6	-1.9	-1.5	-0.2	-1.0	0.5	-0.4
Medication: Omeprazole	0.8	1.0	3.3	1.8	0.4	1.4	0.1	0.2	1.2	0.3
Alcohol intake frequency.	0.8	1.8	7.1	-2.7	0.7	-1.4	-1.0	-0.2	-1.1	-0.8
Hypertension (Self-reported)	0.8	2.2	8.2	2.9	-0.2	-1.8	-0.7	-0.4	1.9	-0.1
Diabetes diagnosed by doctor	0.8	1.3	5.1	2.3	0.1	1.4	0.9	-1.0	0.1	-0.3
Commuting to job workplace: Walk	0.8	0.8	1.9	-1.1	-0.7	0.1	-1.4	-0.8	-0.6	-1.1
Medication: Atorvastatin	0.8	0.9	1.9	-0.9	-1.2	1.4	-0.8	-0.8	0.5	-1.0
Average weekly beer plus cider intake	0.8	1.2	3.9	0.7	0.7	0.8	2.0	-1.4	0.7	-0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.8	0.7	0.9	0.7	-1.9	-0.3	-0.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	4.1	2.0	0.4	1.3	-0.1	-0.4	0.9	-0.1
Pain experienced in last month	0.8	1.3	4.4	0.6	1.4	-0.6	-0.3	2.1	0.7	1.2
Bipolar Disorder (2011)	0.7	0.7	3.1	0.5	-0.9	0.9	1.8	-0.4	0.0	0.0
Waist Hip Ratio (WHR)	0.7	3.2	7.2	0.1	-1.7	1.1	-2.0	-2.7	-0.3	-2.6
Chronotype (morning person)	0.7	1.5	3.2	-1.4	0.2	-0.6	-1.4	-1.7	0.5	-1.8
Ever had hysterectomy (womb removed)	0.7	0.8	1.4	0.4	1.1	1.2	0.2	0.8	1.1	0.8
Impedance of leg (right)	0.7	3.4	7.5	0.5	-0.1	-1.7	-2.7	-2.6	0.7	-2.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.8	-1.0	-0.4	1.4	1.1	0.4	-1.0	0.2
Allergy	0.7	1.6	2.8	-1.5	1.0	-0.5	-1.4	-1.5	-0.4	-1.7
Number of live births	0.7	0.9	2.8	-0.1	-1.1	0.7	1.0	-1.7	0.2	-1.0
Illnesses of mother	0.7	0.9	3.8	-0.4	0.4	0.9	-0.0	1.9	0.5	1.1
Hair/balding pattern: Pattern 4	0.7	1.7	2.8	-1.6	1.0	-0.0	-1.1	-1.4	-1.7	-1.6
Gout (self-reported)	0.7	0.9	2.4	-0.0	-1.5	-1.3	0.1	-1.4	-0.1	-0.6
Wheeze or whistling in the chest in last year	0.7	1.3	2.7	1.3	-1.6	1.6	1.1	0.4	0.2	0.7
Neck or shoulder pain in last month	0.7	1.0	3.0	-0.6	0.1	0.9	1.7	1.0	-0.2	1.3
Loneliness, isolation	0.7	0.9	1.5	-1.0	-0.9	-1.2	0.8	-1.1	-1.2	-0.3
Eye problems/disorders: Cataract	0.7	0.9	2.2	0.6	0.4	-1.2	-0.7	1.5	0.5	1.1
Miserableness	0.7	1.1	3.0	-0.8	-1.3	-0.0	1.7	-1.0	-1.3	-0.1
Medication: Blood pressure	0.7	1.3	6.1	2.5	-0.0	-1.0	0.1	0.7	1.2	0.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.5	1.2	-0.6	1.0	0.7	0.8	0.9	1.2
Ulcerative Colitis (UC)	0.6	1.2	5.4	-0.1	-2.3	-1.6	-0.2	0.1	0.4	-0.2
Age at First Birth	0.6	0.8	3.5	1.4	0.3	-0.1	-0.6	1.9	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.6	1.0	5.2	2.3	-1.0	1.0	0.3	-0.1	0.4	-0.1
Sensitivity / hurt feelings	0.6	1.0	3.6	1.2	0.1	1.4	1.9	-0.4	0.1	0.3
Vitamin and mineral supplements	0.6	0.9	3.0	1.5	0.3	-0.2	-1.7	-0.3	0.4	-0.6
Average weekly fortified wine intake	0.6	0.7	3.0	0.9	1.7	-0.2	0.5	0.5	0.1	0.6
Taking other prescription medications	0.6	0.9	2.8	0.6	-0.4	-1.7	0.5	0.6	-1.5	0.4
Serious illness, injury or assault to yourself	0.6	0.8	2.5	-0.4	0.1	-0.0	0.7	1.6	0.3	1.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.5	1.1	-1.1	0.8	0.9	1.6	0.7	1.6
Medication: Atenolol	0.6	0.7	1.5	1.2	-0.1	0.3	-0.7	-0.8	1.1	-1.0
Alcohol usually taken with meals	0.6	0.9	2.9	-1.7	0.6	1.3	0.6	0.3	-1.0	0.1
Hair/balding pattern: Pattern 2	0.6	0.8	2.2	0.4	1.5	-1.0	-0.5	0.4	-1.3	-0.1
Length of working week for main job	0.6	0.7	2.1	-1.0	0.3	-0.4	-1.4	-0.3	0.9	-0.8
Exposure to tobacco smoke at home	0.6	0.6	1.6	0.8	0.8	1.3	0.7	-0.5	0.7	0.5
Birth weight of first child	0.6	1.0	4.3	-2.1	-0.4	0.3	-0.8	-0.2	-1.3	-0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.5	1.6	0.6	1.4	-0.6	-0.3	-0.2	-0.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.0	-0.1	1.2	0.9	1.7	0.9	-0.1	0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	0.7	-0.9	1.3	1.3	0.1	0.3	0.6
Knee pain experienced in last month	0.6	0.9	1.9	1.1	-1.4	-0.5	0.9	0.8	0.8	0.9
Mood swings	0.6	1.0	4.0	-0.2	-0.7	-0.3	2.0	0.6	-1.2	0.9
Back pain experienced in last month	0.6	0.8	1.6	-0.8	-1.3	-0.1	-1.0	-1.1	-0.0	-1.2
Eye problems/disorders: Glaucoma	0.6	0.7	2.7	-0.1	0.0	0.3	1.6	0.4	-1.2	0.5
High cholesterol (Self-reported)	0.6	1.0	3.7	1.9	-1.1	0.4	0.7	0.6	-0.3	1.0
Unable to work because of sickness or disability	0.6	0.8	1.9	-0.1	-0.3	-0.7	1.3	0.8	1.0	1.4
Vascular/heart problems diagnosed by doctor	0.6	1.7	5.5	-2.3	0.0	1.7	0.4	0.8	-1.6	0.3
Basal cell carcinoma (self-reported)	0.6	0.7	2.4	-1.5	-0.9	-0.3	-1.1	-0.1	0.1	-0.6
LDL Cholesterol	0.5	0.8	3.4	0.6	0.1	1.8	1.0	-0.8	0.0	0.0
Blood White Count	0.5	3.8	8.3	0.1	0.6	-1.7	-2.7	-2.9	-0.4	-2.9
Lung FVC	0.5	2.3	7.1	-2.6	0.5	-0.7	-2.7	0.9	-0.7	-0.4
Hand grip strength (left)	0.5	1.2	4.1	-0.1	0.8	-1.8	0.0	-0.5	-2.0	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.2	-0.0	-0.7	-0.7	1.5	0.7	-0.3	1.2
Diabetes (mother)	0.5	0.7	2.2	1.1	-0.4	1.5	0.1	-0.2	1.0	-0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.4	0.5	1.5	-0.4	0.6	0.3	0.6	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	6.2	-0.6	-0.6	-2.5	-0.6	0.5	-1.0	-0.0
Impedance of leg (left)	0.5	2.6	6.8	0.9	0.5	-1.3	-2.0	-2.6	0.8	-2.0
Diabetes (self-reported)	0.5	0.7	3.4	1.8	-0.2	0.9	0.7	-0.4	-0.2	0.1
Medication: Simvastatin	0.5	0.8	3.0	1.7	-0.2	-1.3	0.4	0.2	0.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.2	0.4	-1.8	1.1	0.4	0.5	0.4	0.5
Depression (self-reported)	0.5	0.6	1.6	0.3	0.0	0.8	1.0	1.1	0.2	1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.4	-0.2	-1.2	1.6	0.2	-0.0	0.3	-0.0
Glaucoma (self-reported)	0.5	0.6	2.8	-0.6	0.4	0.1	1.7	0.2	-0.8	0.6
Medication: Amlodipine	0.5	0.7	2.3	1.5	0.1	1.1	0.1	0.8	0.6	0.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	2.0	-0.2	-0.8	0.6	-1.4	-0.5	0.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.1	0.9	1.5	-0.6	-0.6	0.4	0.0	-0.1
Angina (self-reported)	0.5	0.7	2.5	0.3	-0.6	0.6	1.6	0.6	0.1	1.0
Comparative height size at age 10	0.5	2.7	5.3	-2.3	-0.9	-1.2	2.0	-1.3	-2.3	-0.7
Leg pain on walking	0.5	0.6	3.2	0.5	-0.5	0.2	1.8	-0.6	-0.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.8	1.7	0.7	-0.0	0.0	-0.0	0.7	0.1
Illnesses of siblings: Diabetes	0.5	0.7	2.1	1.5	-0.4	0.9	-0.0	-0.2	1.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.0	-1.1	-1.1	-0.5	2.0	0.2	-0.8	0.4
Osteoarthritis (self-reported)	0.5	0.7	3.0	1.7	-0.4	0.1	-0.4	1.0	-0.1	0.6
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-1.4	-0.7	0.4	0.8	0.0	-0.9	0.2
Commuting to job workplace: Public transport	0.5	0.6	2.2	-0.8	1.0	-1.5	-0.3	-0.0	-0.6	-0.4
Medication: Lisinopril	0.5	0.7	2.4	0.3	-1.5	-0.2	-1.3	0.7	0.1	0.1
Myopia	0.5	0.7	2.5	-0.1	0.7	0.2	-1.1	0.2	-1.6	-0.6
Heel T-Score	0.4	3.0	13.8	0.2	-1.0	-3.7	-0.8	2.1	-0.1	1.2
Lung FEV1/FVC ratio	0.4	2.2	6.1	-2.5	1.7	-0.9	-1.6	0.8	-1.4	-0.5
Relative age of first facial hair	0.4	0.8	1.8	-0.3	-1.3	-1.1	-0.5	-1.2	0.2	-1.0
Angina	0.4	0.5	2.2	0.1	-0.6	0.5	1.5	0.3	-0.3	0.7
Medication: Metformin	0.4	0.6	1.8	1.4	-0.0	1.1	0.8	-0.2	0.6	0.4
Diabetes (father)	0.4	0.5	1.9	1.4	-0.2	-0.6	0.3	0.2	-1.0	0.5
Hand grip strength (right)	0.4	1.2	2.5	-0.5	0.8	-1.6	-1.2	-0.9	-1.2	-1.0
Sitting height	0.4	2.6	10.0	-0.2	0.4	-1.3	3.2	1.5	-1.1	1.8
Past tobacco smoking	0.4	0.7	2.2	-1.5	0.7	-0.3	-1.3	0.0	-0.2	-0.5
Hearing difficulty/problems with background noise	0.4	0.6	1.9	1.4	-0.7	0.7	-1.0	0.2	-0.3	-0.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.6	0.0	-1.0	-0.3	-0.3	0.3	-1.6	-0.2
Time employed in main current job	0.4	0.4	1.0	-1.0	0.4	-0.8	-1.0	0.0	0.4	-0.3
Alcohol intake versus 10 years previously	0.4	0.6	1.4	-0.6	-1.2	-0.1	0.8	0.6	0.6	0.9
Heart disease (mother)	0.4	0.5	2.4	1.5	0.1	0.1	-0.7	-0.9	0.1	-0.4
Suffer from ‘nerves’	0.4	0.7	3.0	-0.2	-0.8	-1.7	-0.8	0.0	-0.6	0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.7	-0.6	0.6	-0.9	-0.7	0.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	-0.1	-0.0	0.9	1.1	-0.8	1.0	0.1
Number of self-reported non-cancer illnesses	0.4	0.8	2.8	1.7	-0.5	-0.9	0.2	-0.4	-1.1	-0.3
Guilty feelings	0.4	0.6	2.3	0.5	0.2	-0.2	1.5	-0.8	-0.7	-0.0
Age started oral contraceptive pill	0.4	0.5	1.4	0.6	1.2	0.0	0.2	0.6	0.8	0.7
Neuroticism (Nagel 2018)	0.3	0.6	2.3	-0.2	-0.2	0.7	1.5	-0.8	-0.9	-0.1
Reaction Time	0.3	0.6	1.4	1.2	0.3	1.2	0.9	-0.3	0.5	0.6
Mean Putamen Volume	0.3	0.3	1.1	0.0	-0.2	1.1	-0.7	-0.2	0.5	-0.2
HDL Cholesterol	0.3	0.5	2.9	0.1	-0.5	-0.8	-0.2	1.7	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.4	2.0	0.0	0.3	-0.6	0.4	1.4	0.0	0.0
Ulcerative Colitis	0.3	0.4	1.4	-0.1	-0.9	-1.2	-0.4	-0.0	0.5	-0.3
Neuroticism	0.3	0.7	2.3	0.1	0.5	1.0	1.5	-0.5	-1.2	-0.0
Medication for hormone replacement therapy	0.3	0.3	0.9	0.7	-1.0	-0.2	0.5	-0.4	0.2	0.1
Townsend deprivation index at recruitment	0.3	0.5	1.2	-0.0	-0.3	-0.4	0.8	1.1	-0.1	1.1
Fed-up feelings	0.3	0.6	1.1	-1.0	-1.0	0.7	1.1	-0.3	0.4	0.2
Relative age voice broke	0.3	0.5	2.3	0.3	-1.5	-0.5	-0.7	-0.3	-0.1	-0.2
Had menopause	0.3	0.3	1.0	0.3	0.4	-0.5	-0.4	-0.6	1.0	-0.4
Heart attack	0.3	0.3	0.9	0.4	-0.4	-0.5	0.4	0.4	0.9	0.7
Pain all over the body in last month	0.3	0.3	0.9	-0.6	-0.6	1.0	-0.3	-0.5	0.1	-0.4
Neuroticism score	0.3	0.6	2.3	-0.2	-0.2	0.6	1.5	-0.8	-1.1	-0.1
Medication: Cholesterol lowering	0.3	0.5	2.7	0.0	-1.6	-0.0	-0.6	-0.3	-0.6	-0.1
Tense / ‘highly strung’	0.3	0.6	1.5	-0.3	0.6	-0.8	-0.1	-1.2	-0.7	-1.0
Eye problems/disorders: None of the above	0.3	0.4	1.0	-0.4	-0.5	1.0	0.6	-0.6	-0.7	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	-0.6	-0.7	0.0	-0.7	-0.7	-0.2	-0.8
Chest pain or discomfort	0.3	0.4	1.8	-0.4	0.0	-0.2	1.4	-0.1	-0.8	0.1
Supplements: Vitamin C	0.3	0.4	1.6	-0.7	1.3	-0.2	-0.3	-0.3	0.0	-0.4
Smoking status: Previous	0.3	0.5	2.3	1.5	-0.4	-0.3	0.8	-0.4	0.1	0.1
Average weekly red wine intake	0.3	0.5	2.0	0.3	1.4	-0.4	0.0	0.5	-0.8	0.4
Financial situation satisfaction	0.3	0.4	1.3	0.2	-0.8	1.1	-0.1	0.6	-0.0	0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.3	1.1	-0.9	-0.3	0.3	-0.3	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.5	-0.2	-0.5	0.5	0.5	1.0	0.8
Rheumatoid Arthritis	0.2	0.3	1.3	0.5	1.1	-0.3	0.1	0.3	-0.0	0.3
Allergy or Eczema	0.2	0.5	0.9	0.7	-0.6	0.6	0.9	0.6	-0.4	0.9
Tanning	0.2	2.0	4.4	1.8	1.2	-1.1	-0.5	2.1	0.5	1.7
Number of treatments/medications taken	0.2	0.3	1.2	-0.6	-0.4	-1.1	0.2	0.2	-0.8	-0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	-0.1	-0.3	-0.8	0.2	-0.5	-1.0	0.0
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.4	0.0	-0.4	-0.0	-0.2	-0.3	1.2	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.9	0.6	-0.2	-1.4	-0.7	0.8	-0.4	0.3
Standing height	0.2	2.0	5.2	-1.9	-0.2	-0.6	2.3	-0.4	-2.2	0.0
Loud music exposure frequency	0.2	0.2	0.6	0.5	-0.2	0.1	0.3	0.8	0.6	0.6
Mean time to correctly identify matches	0.2	0.4	1.9	0.4	0.4	1.4	0.7	-0.6	0.2	0.2
Long-standing illness, disability or infirmity	0.2	0.4	1.0	0.1	-0.9	1.0	0.6	0.3	0.3	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.2	0.5	-0.4	0.7	1.1	-0.3	0.1	0.0
Osteoporosis (self-reported)	0.2	0.2	0.9	-0.2	-0.6	-0.0	-0.9	0.0	-0.5	-0.2
Wears glasses or contact lenses	0.2	0.2	0.6	-0.8	-0.2	-0.1	-0.5	0.4	-0.7	0.1
Number of operations (self-reported)	0.2	0.3	1.0	-0.5	-0.1	-0.5	0.3	-0.3	-1.0	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.3	0.5	-0.5	-0.3	-0.6	0.0	-0.5
Fasting Glucose	0.1	0.1	0.5	-0.3	-0.3	-0.7	0.1	0.2	0.0	0.0
Height	0.1	2.8	7.7	-1.6	0.1	-1.0	2.5	-1.2	-2.8	-0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.5	-0.6	-0.1	-0.5	0.1	0.6	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.3	3.0	0.7	0.1	1.7	1.3	-1.7	0.3	-0.7
Breast cancer (self-reported)	0.0	0.0	0.1	0.0	-0.3	0.3	0.0	0.0	-0.2	0.0

Hub : Genes

ANAPC7

Models

Trait associations