Best TWAS P=2e-09 · Best GWAS P=7.08e-11 conditioned to 0.000585
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | AAGAB | 0.06 | 0.05 | enet | 11 | 0.05 | 3.2e-07 | -5.3 | -5.7 | 1.4e-08 | 0.67 | 0.05 | 0.95 | FALSE |
2 | GTEx | Brain Cerebellum | MAP2K5 | 0.27 | 0.12 | lasso | 5 | 0.14 | 7.9e-05 | -6.0 | 5.6 | 1.8e-08 | -0.67 | 0.06 | 0.89 | FALSE |
3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IQCH | 0.13 | 0.07 | blup | 112 | 0.10 | 5.2e-09 | -4.3 | 5.4 | 5.5e-08 | -0.48 | 0.12 | 0.88 | FALSE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IQCH | 0.06 | 0.05 | blup | 112 | 0.06 | 5.2e-12 | -6.1 | 6.0 | 2.0e-09 | -0.65 | 0.04 | 0.96 | TRUE |
5 | The Cancer Genome Atlas | Colon Adenocarcinoma | IQCH | 0.08 | 0.02 | blup | 111 | 0.05 | 4.2e-04 | -4.2 | 5.8 | 8.9e-09 | -0.61 | 0.10 | 0.79 | FALSE |
6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IQCH | 0.05 | 0.04 | blup | 111 | 0.04 | 7.7e-06 | -4.3 | 5.5 | 4.1e-08 | -0.58 | 0.13 | 0.85 | FALSE |
7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | IQCH | 0.11 | 0.10 | blup | 112 | 0.10 | 2.3e-07 | -2.5 | 5.3 | 1.4e-07 | -0.61 | 0.34 | 0.65 | FALSE |
8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IQCH | 0.35 | 0.04 | blup | 112 | 0.12 | 1.5e-05 | -4.3 | 5.7 | 9.6e-09 | -0.46 | 0.09 | 0.82 | FALSE |