TWAS
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Models
Genes
Traits
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Traits
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Alcohol intake versus 10 years previously
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chr2:26,883,355-28,288,392
Best TWAS P=1.07e-11 · Best GWAS P=4.74e-11 conditioned to 1
26.8M
27M
27.2M
27.4M
27.6M
27.8M
28M
28.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
FNDC4
0.13
0.06
lasso
2
0.05
1.1e-03
6.6
-6.8
1.1e-11
-0.99
0.00
0.94
TRUE
3
The Cancer Genome Atlas
Thyroid Carcinoma
FNDC4
0.24
0.09
enet
9
0.17
1.9e-16
-3.6
-5.8
6.1e-09
-0.70
0.34
0.66
FALSE
1
GTEx
Testis
AC074117.10
0.14
0.08
lasso
6
0.12
4.5e-06
-3.8
5.5
3.2e-08
0.85
0.04
0.96
FALSE