[Hub]/) : Traits : Alcohol intake versus 10 years previously : ← →

chr3:49,016,056-50,921,261

Best TWAS P=4.19e-10 · Best GWAS P=6.28e-09 conditioned to 0.0493

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	5.5	6.2	4.2e-10	-0.71	0.12	0.88	TRUE
19	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	-5.8	6.2	4.3e-10	-0.92	0.06	0.94	FALSE
33	GTEx	Colon Transverse	RBM6	0.29	0.33	enet	43	0.36	4.6e-18	-5.7	-6.1	9.4e-10	0.95	0.04	0.96	FALSE
69	GTEx	Vagina	RBM6	0.24	0.22	enet	27	0.21	1.5e-05	-5.2	-6.1	1.2e-09	0.94	0.05	0.94	FALSE
24	GTEx	Brain Nucleus accumbens basal ganglia	RBM6	0.20	0.19	enet	29	0.22	2.0e-06	-5.8	-6.1	1.4e-09	0.88	0.07	0.92	FALSE
64	GTEx	Testis	RBM6	0.28	0.14	enet	19	0.17	7.7e-08	5.4	-6.1	1.4e-09	0.90	0.08	0.92	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRAIP	0.02	0.01	enet	8	0.01	3.1e-02	5.2	6.1	1.4e-09	-0.73	0.02	0.61	FALSE
4	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	-5.8	-6.0	1.7e-09	0.97	0.04	0.96	FALSE
17	GTEx	Brain Cerebellar Hemisphere	FAM212A	0.25	0.17	lasso	21	0.20	8.1e-06	-5.7	6.0	2.0e-09	-0.86	0.06	0.87	FALSE
28	GTEx	Cells EBV-transformed lymphocytes	RBM6	0.27	0.21	enet	14	0.23	5.0e-08	-5.7	-6.0	2.3e-09	0.98	0.04	0.96	FALSE
18	GTEx	Brain Cerebellum	RBM6	0.25	0.41	enet	32	0.33	2.1e-10	-5.8	-5.9	3.1e-09	0.97	0.05	0.95	FALSE
10	GTEx	Artery Coronary	RBM6	0.14	0.14	enet	23	0.15	1.0e-05	5.5	-5.9	3.4e-09	0.85	0.10	0.90	FALSE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBA7	0.02	0.01	blup	30	0.02	5.3e-03	5.3	-5.9	3.4e-09	0.80	0.01	0.84	FALSE
11	GTEx	Artery Tibial	RBM6	0.24	0.31	enet	24	0.30	5.8e-24	-5.8	-5.9	3.5e-09	0.97	0.04	0.96	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	RBM6	0.14	0.19	blup	79	0.20	1.4e-19	-5.8	-5.9	3.9e-09	0.97	0.03	0.97	FALSE
35	GTEx	Esophagus Gastroesophageal Junction	RBM6	0.25	0.29	lasso	23	0.30	2.2e-11	-5.2	-5.9	4.0e-09	0.93	0.06	0.94	FALSE
82	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RBM6	0.06	0.09	enet	27	0.10	9.3e-09	-5.7	-5.9	4.3e-09	0.97	0.03	0.97	FALSE
12	GTEx	Artery Tibial	MST1R	0.06	0.02	lasso	5	0.02	1.5e-02	5.5	5.9	4.8e-09	-0.80	0.06	0.70	FALSE
49	GTEx	Nerve Tibial	RBM6	0.41	0.42	enet	19	0.41	8.8e-31	-5.8	-5.9	4.8e-09	0.98	0.04	0.96	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	FAM212A	0.05	0.04	enet	21	0.01	1.1e-01	-5.7	5.9	4.8e-09	-0.98	0.05	0.91	FALSE
26	GTEx	Breast Mammary Tissue	RBM6	0.25	0.35	enet	26	0.38	7.4e-21	-5.7	-5.8	5.0e-09	0.98	0.04	0.96	FALSE
29	GTEx	Cells Transformed fibroblasts	RBM6	0.27	0.29	enet	17	0.31	1.3e-23	-5.8	-5.8	5.1e-09	0.97	0.04	0.96	FALSE
66	GTEx	Thyroid	RBM6	0.25	0.35	lasso	15	0.36	1.9e-28	-5.8	-5.8	5.1e-09	0.97	0.05	0.95	FALSE
48	GTEx	Muscle Skeletal	RBM6	0.11	0.15	enet	13	0.15	3.1e-14	-5.7	-5.8	5.8e-09	0.96	0.05	0.95	FALSE
75	NTR	Blood	RBM6	0.06	0.14	enet	36	0.13	7.9e-40	-5.7	-5.8	6.4e-09	0.98	0.04	0.96	FALSE
27	GTEx	Breast Mammary Tissue (Female)	RBM6	0.23	0.27	enet	16	0.26	2.7e-08	5.5	-5.8	6.8e-09	0.97	0.05	0.95	FALSE
44	GTEx	Heart Left Ventricle	RBM6	0.09	0.08	enet	10	0.11	3.0e-06	-5.8	-5.8	6.8e-09	0.96	0.06	0.94	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	RBM6	0.10	0.14	enet	17	0.14	7.7e-16	-5.7	-5.8	6.8e-09	0.98	0.03	0.97	FALSE
51	GTEx	Pancreas	RBM6	0.23	0.20	lasso	4	0.22	1.3e-09	-5.8	-5.8	7.0e-09	0.98	0.04	0.96	FALSE
42	GTEx	Heart Atrial Appendage	RBM6	0.34	0.36	lasso	6	0.35	1.2e-16	-5.8	-5.8	7.1e-09	0.97	0.06	0.94	FALSE
60	GTEx	Spleen	RBM6	0.36	0.39	lasso	8	0.40	2.0e-11	-5.8	-5.8	7.2e-09	0.95	0.04	0.96	FALSE
57	GTEx	Skin Sun Exposed Lower leg	RBM6	0.23	0.27	lasso	8	0.29	7.6e-24	-5.8	-5.8	7.3e-09	0.97	0.04	0.96	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	RBM6	0.08	0.06	blup	79	0.07	4.3e-08	5.5	-5.8	7.3e-09	0.94	0.03	0.97	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RBM6	0.04	0.05	blup	79	0.05	2.0e-06	5.5	-5.8	7.8e-09	0.95	0.06	0.94	FALSE
9	GTEx	Artery Aorta	UBA7	0.06	0.02	enet	12	0.01	5.3e-02	5.5	-5.8	7.9e-09	0.89	0.07	0.84	FALSE
70	GTEx	Whole Blood	RBM6	0.14	0.19	lasso	3	0.18	2.4e-16	-5.7	-5.8	7.9e-09	0.98	0.04	0.96	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	MST1R	0.05	0.07	enet	7	0.05	7.1e-04	-5.8	5.8	8.0e-09	-0.99	0.04	0.94	FALSE
6	GTEx	Adrenal Gland	RBM6	0.12	0.05	enet	18	0.05	5.9e-03	-5.7	-5.8	8.2e-09	0.98	0.04	0.93	FALSE
99	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RBM6	0.09	0.07	blup	79	0.08	1.3e-04	-5.8	-5.8	8.5e-09	0.95	0.05	0.94	FALSE
7	GTEx	Artery Aorta	RBM6	0.32	0.36	lasso	6	0.41	3.3e-24	-5.8	-5.8	8.6e-09	0.97	0.04	0.96	FALSE
37	GTEx	Esophagus Mucosa	RNF123	0.07	0.03	enet	9	0.04	1.8e-03	5.4	5.8	8.6e-09	-0.73	0.13	0.79	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	RBM6	0.09	0.15	enet	16	0.15	1.1e-15	-5.7	-5.8	8.8e-09	0.97	0.03	0.97	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RBM6	0.05	0.06	lasso	10	0.04	9.1e-06	-5.7	-5.7	9.0e-09	0.98	0.03	0.97	FALSE
63	GTEx	Stomach	RBM6	0.16	0.22	lasso	11	0.19	2.1e-09	-5.7	-5.7	9.3e-09	0.98	0.04	0.96	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RBM6	0.09	0.11	blup	79	0.11	3.8e-12	-5.8	-5.7	9.3e-09	0.97	0.03	0.97	FALSE
53	GTEx	Prostate	RBM6	0.14	0.12	enet	15	0.05	1.8e-02	-5.8	-5.7	9.8e-09	0.96	0.05	0.86	FALSE
13	GTEx	Artery Tibial	UBA7	0.04	0.03	lasso	4	0.02	7.8e-03	-5.5	-5.7	1.0e-08	0.81	0.09	0.56	FALSE
46	GTEx	Lung	RBM6	0.17	0.20	lasso	6	0.24	4.6e-18	-5.8	-5.7	1.0e-08	0.96	0.05	0.95	FALSE
52	GTEx	Pituitary	RBM6	0.27	0.21	enet	22	0.19	1.5e-05	-5.8	-5.7	1.0e-08	0.90	0.07	0.92	FALSE
25	GTEx	Brain Putamen basal ganglia	RBM6	0.15	0.22	lasso	4	0.12	7.4e-04	-5.7	-5.7	1.1e-08	0.98	0.06	0.91	FALSE
32	GTEx	Colon Sigmoid	RBM6	0.25	0.19	enet	7	0.13	2.3e-05	-5.8	-5.7	1.1e-08	0.97	0.05	0.95	FALSE
45	GTEx	Liver	RBM6	0.21	0.11	enet	6	0.09	1.4e-03	5.5	-5.7	1.1e-08	0.96	0.06	0.89	FALSE
47	GTEx	Lung	MST1R	0.06	0.04	lasso	3	0.04	7.5e-04	-5.8	5.7	1.2e-08	-0.98	0.05	0.91	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	RBM6	0.16	0.17	enet	24	0.23	1.2e-12	-5.2	-5.7	1.2e-08	0.95	0.05	0.95	FALSE
36	GTEx	Esophagus Mucosa	RBM6	0.18	0.21	enet	18	0.23	3.0e-15	5.5	-5.7	1.3e-08	0.94	0.05	0.95	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	5.6	5.7	1.4e-08	-0.74	0.12	0.83	FALSE
62	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	5.3	-5.7	1.4e-08	0.76	0.12	0.76	FALSE
85	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RBM6	0.09	0.13	blup	79	0.12	1.6e-06	-5.8	-5.7	1.4e-08	0.97	0.03	0.97	FALSE
65	GTEx	Testis	MON1A	0.08	0.06	enet	13	0.05	2.4e-03	5.1	-5.7	1.5e-08	0.89	0.10	0.78	FALSE
34	GTEx	Colon Transverse	UBA7	0.28	0.30	lasso	2	0.30	1.1e-14	5.6	-5.6	1.8e-08	0.76	0.12	0.88	FALSE
38	GTEx	Esophagus Mucosa	UBA7	0.04	0.07	enet	8	0.05	4.5e-04	5.4	-5.6	1.8e-08	0.82	0.10	0.88	FALSE
76	NTR	Blood	UBA7	0.02	0.03	lasso	4	0.03	1.6e-09	5.4	-5.6	1.8e-08	0.82	0.11	0.89	FALSE
40	GTEx	Esophagus Muscularis	RBM6	0.22	0.29	lasso	7	0.30	1.1e-18	-5.8	-5.6	1.9e-08	0.97	0.05	0.95	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	RBM6	0.03	0.04	blup	79	0.05	9.5e-10	-5.7	-5.6	1.9e-08	0.95	0.03	0.97	FALSE
30	GTEx	Cells Transformed fibroblasts	MST1R	0.05	0.04	lasso	3	0.04	3.8e-04	-5.7	5.6	2.0e-08	-0.89	0.04	0.93	FALSE
59	GTEx	Skin Sun Exposed Lower leg	FAM212A	0.05	0.07	enet	16	0.06	1.1e-05	5.6	5.6	2.0e-08	-0.76	0.11	0.89	FALSE
68	GTEx	Thyroid	MST1R	0.06	0.06	enet	9	0.05	1.7e-04	5.5	5.6	2.0e-08	-0.89	0.06	0.93	FALSE
107	The Cancer Genome Atlas	Stomach Adenocarcinoma	RBM6	0.05	0.05	blup	79	0.06	3.7e-05	-5.7	-5.6	2.1e-08	0.95	0.03	0.94	FALSE
8	GTEx	Artery Aorta	APEH	0.05	0.03	enet	8	0.01	9.1e-02	-5.7	-5.6	2.2e-08	0.94	0.07	0.84	FALSE
61	GTEx	Spleen	RNF123	0.13	0.13	lasso	5	0.10	1.3e-03	5.6	5.6	2.4e-08	-0.75	0.09	0.58	FALSE
109	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RBM6	0.16	0.12	blup	79	0.09	4.4e-04	-5.7	-5.6	2.4e-08	0.93	0.03	0.96	FALSE
86	The Cancer Genome Atlas	Colon Adenocarcinoma	UBA7	0.11	0.06	enet	5	0.05	7.6e-04	5.5	-5.6	2.5e-08	0.68	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	RBM6	0.25	0.35	lasso	9	0.35	1.8e-29	-5.8	-5.6	2.6e-08	0.95	0.05	0.95	FALSE
41	GTEx	Esophagus Muscularis	RNF123	0.15	0.14	enet	17	0.14	1.2e-08	5.5	5.6	2.6e-08	-0.75	0.11	0.89	FALSE
71	GTEx	Whole Blood	UBA7	0.03	0.04	lasso	2	0.01	1.5e-02	5.4	-5.6	2.7e-08	0.79	0.10	0.79	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RBM6	0.16	0.19	lasso	9	0.19	1.2e-22	-5.8	-5.5	3.0e-08	0.98	0.05	0.95	FALSE
39	GTEx	Esophagus Mucosa	FAM212A	0.19	0.26	enet	24	0.27	4.4e-18	5.6	5.5	3.0e-08	-0.76	0.12	0.88	FALSE
94	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBA7	0.13	0.16	lasso	6	0.15	1.1e-08	5.5	-5.5	3.2e-08	0.76	0.01	0.99	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RBM6	0.19	0.28	lasso	5	0.32	7.4e-09	5.4	-5.5	3.3e-08	0.93	0.05	0.95	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	RBM6	0.21	0.32	enet	31	0.34	1.5e-44	-5.8	-5.5	3.3e-08	0.96	0.04	0.96	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA3F	0.02	0.04	lasso	3	0.03	2.3e-04	-5.5	-5.5	3.4e-08	0.76	0.00	0.96	FALSE
20	GTEx	Brain Cerebellum	FAM212A	0.27	0.35	lasso	5	0.34	9.7e-11	5.6	5.5	3.5e-08	-0.75	0.12	0.88	FALSE
23	GTEx	Brain Frontal Cortex BA9	RBM6	0.18	0.25	lasso	3	0.20	5.2e-06	5.5	5.5	3.5e-08	-0.92	0.06	0.94	FALSE
22	GTEx	Brain Cortex	RNF123	0.23	0.05	enet	33	0.04	2.4e-02	5.6	5.5	3.8e-08	-0.76	0.10	0.61	FALSE
67	GTEx	Thyroid	RNF123	0.09	0.13	lasso	9	0.12	2.7e-09	5.5	5.5	3.8e-08	-0.75	0.12	0.88	FALSE
21	GTEx	Brain Cortex	RBM6	0.21	0.25	lasso	4	0.29	8.8e-09	-5.8	-5.5	4.1e-08	0.91	0.05	0.95	FALSE
80	YFS	Blood	RBM6	0.28	0.43	enet	57	0.44	4.0e-160	-5.8	-5.5	4.2e-08	0.98	0.04	0.96	FALSE
58	GTEx	Skin Sun Exposed Lower leg	MST1R	0.06	0.07	lasso	2	0.06	1.1e-05	5.5	5.5	4.3e-08	-0.92	0.06	0.93	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	MST1R	0.03	0.01	blup	32	0.03	3.1e-04	5.5	5.5	4.8e-08	-0.93	0.02	0.94	FALSE
73	METSIM	Adipose	RBM6	0.22	0.34	lasso	15	0.34	1.7e-52	-5.7	-5.4	5.1e-08	0.97	0.04	0.96	FALSE
93	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RBM6	0.14	0.17	lasso	5	0.17	5.7e-10	5.5	-5.4	5.5e-08	0.96	0.03	0.97	FALSE
105	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UBA7	0.11	0.14	enet	7	0.11	2.7e-05	5.3	-5.4	5.5e-08	0.75	0.02	0.97	FALSE
74	METSIM	Adipose	RNF123	0.03	0.02	lasso	12	0.02	2.0e-04	5.5	5.4	5.7e-08	-0.72	0.12	0.86	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	UBA7	0.03	0.04	enet	9	0.02	1.8e-03	5.5	-5.4	5.8e-08	0.75	0.02	0.98	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APEH	0.02	0.02	blup	49	0.02	2.5e-03	-4.4	-5.4	6.3e-08	0.58	0.05	0.62	FALSE
104	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CAMKV	0.07	0.05	enet	9	0.06	2.3e-03	5.4	5.4	6.8e-08	-0.70	0.02	0.66	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	SEMA3F	0.07	0.11	bslmm	275	0.10	4.9e-13	5.1	-5.4	7.0e-08	0.87	0.22	0.78	FALSE
31	GTEx	Cells Transformed fibroblasts	UBA7	0.07	0.06	enet	5	0.04	7.5e-04	5.4	-5.4	7.1e-08	0.75	0.16	0.84	FALSE
16	GTEx	Brain Cerebellar Hemisphere	MST1R	0.30	0.08	enet	25	0.10	1.8e-03	5.5	5.4	7.2e-08	-0.76	0.06	0.81	FALSE
108	The Cancer Genome Atlas	Stomach Adenocarcinoma	UBA7	0.04	0.05	lasso	1	0.04	1.0e-03	5.4	-5.4	7.4e-08	0.75	0.02	0.93	FALSE
81	YFS	Blood	UBA7	0.16	0.24	lasso	6	0.23	4.0e-75	5.3	-5.4	7.6e-08	0.75	0.22	0.78	FALSE
5	GTEx	Adipose Visceral Omentum	RNF123	0.08	0.11	lasso	4	0.07	2.2e-04	5.6	5.4	7.8e-08	-0.75	0.12	0.86	FALSE
43	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	5.4	5.4	8.4e-08	-0.69	0.11	0.67	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MST1R	0.03	0.04	blup	32	0.05	4.0e-06	5.5	5.4	8.4e-08	-0.92	0.02	0.98	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	UBA7	0.01	0.01	enet	5	0.01	6.6e-04	5.5	-5.3	9.0e-08	0.71	0.02	0.97	FALSE
72	METSIM	Adipose	MST1R	0.03	0.02	blup	331	0.02	1.7e-03	5.5	5.3	9.9e-08	-0.83	0.28	0.68	FALSE
92	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBA7	0.08	0.09	lasso	5	0.09	3.4e-10	5.4	-5.3	1.1e-07	0.75	0.02	0.98	FALSE
95	The Cancer Genome Atlas	Brain Lower Grade Glioma	MST1R	0.08	0.07	enet	10	0.09	2.6e-10	5.5	5.3	1.2e-07	-0.80	0.01	0.98	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	MST1R	0.02	0.00	blup	278	0.01	4.5e-02	5.4	5.3	1.4e-07	-0.90	0.06	0.92	FALSE
50	GTEx	Nerve Tibial	RNF123	0.24	0.16	lasso	5	0.15	1.0e-10	5.5	5.2	1.6e-07	-0.74	0.12	0.88	FALSE
89	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBA7	0.02	0.02	blup	30	0.02	3.8e-03	5.4	-5.2	1.6e-07	0.80	0.01	0.79	FALSE