Best TWAS P=2.39e-12 · Best GWAS P=7.18e-17 conditioned to 0.183
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FLT3 | 0.33 | 0.29 | bslmm | 556 | 0.32 | 3.6e-40 | 5.4 | 5.9 | 3.0e-09 | 0.51 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Muscle Skeletal | MTIF3 | 0.12 | 0.03 | lasso | 5 | 0.03 | 1.2e-03 | -4.7 | -5.9 | 3.3e-09 | -0.09 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Muscle Skeletal | PAN3-AS1 | 0.08 | 0.05 | lasso | 3 | 0.02 | 1.5e-03 | 5.1 | 5.2 | 1.8e-07 | 0.05 | 0.39 | 0.05 | TRUE |
| 4 | GTEx | Nerve Tibial | AL137059.1 | 0.10 | 0.02 | lasso | 3 | 0.03 | 2.9e-03 | 4.0 | -6.2 | 7.9e-10 | -0.05 | 0.03 | 0.90 | TRUE |
| 5 | YFS | Blood | GTF3A | 0.17 | 0.15 | lasso | 5 | 0.19 | 1.1e-58 | 3.8 | -5.3 | 1.1e-07 | -0.05 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FLT3 | 0.10 | 0.06 | lasso | 3 | 0.09 | 8.0e-06 | 5.1 | 5.2 | 1.6e-07 | 0.62 | 0.24 | 0.57 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GTF3A | 0.03 | 0.00 | enet | 8 | 0.01 | 2.3e-02 | 1.1 | 5.3 | 1.1e-07 | 0.07 | 0.02 | 0.69 | TRUE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FLT3 | 0.12 | 0.06 | blup | 96 | 0.06 | 2.4e-03 | 4.9 | 7.0 | 2.4e-12 | 0.65 | 0.09 | 0.65 | TRUE |