TWAS hub - PAN3-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1000	0.0410	0.00770	0.017	NA	0.009	NA	0.011	1.7e-02	NA	0.063	NA	0.04500
2	GTEx	Muscle Skeletal	0.0825	0.0309	0.00210	0.046	NA	0.010	NA	0.025	2.3e-05	NA	0.035	NA	0.00150
3	GTEx	Nerve Tibial	0.1562	0.0461	0.00022	0.052	NA	0.009	NA	0.043	1.5e-04	NA	0.067	NA	0.00049

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative body size at age 10	9.1	25.2	27.2	4.9	5.2	4.9
Pain type(s) experienced in last month: Hip pain	8.9	11.2	13.0	2.9	3.5	3.6
Age when periods started (menarche)	7.4	17.8	22.5	-3.4	-4.4	-4.7
Long-standing illness, disability or infirmity	5.1	7.8	7.8	2.8	2.8	2.8
Tinnitus: Yes, but not now, but have in the past	4.4	4.7	5.2	2.3	2.0	2.2
Ovarian Cancer	4.0	5.3	8.4	-2.9	-2.2	-1.6
Other serious medical condition/disability diagnosed by doctor	3.9	5.1	5.9	2.1	2.4	2.2
Exposure to tobacco smoke outside home	3.8	5.0	5.9	2.4	2.4	1.9
Loneliness, isolation	3.8	5.2	7.1	1.7	2.4	2.7
Schizophrenia vs Biploar Disorder	3.3	4.4	6.3	1.5	2.2	2.5
Hayfever/allergic rhinitis (self-reported)	3.3	4.4	6.1	2.5	1.8	2.0
Lung FEV1/FVC ratio	3.2	16.3	26.4	2.8	3.9	5.1
Illnesses of siblings: Diabetes	3.2	3.9	4.2	2.0	1.8	2.1
Bipolar Disorder (2018)	2.9	4.5	6.3	-1.8	-2.0	-2.5
Commuting to job workplace: Cycle	2.9	3.5	4.1	-2.0	-1.9	-1.7
Blood White Count	2.6	19.0	24.7	5.0	4.0	4.0
Leg fat percentage (left)	2.4	8.5	10.3	3.2	2.9	2.7
Alcohol drinker status: Previous	2.4	2.7	3.2	1.8	1.6	1.6
High blood pressure (mother)	2.3	3.2	4.9	0.9	2.0	2.2
Body mass index (BMI)	2.3	9.8	12.8	3.6	3.0	2.8
Pain experienced in last month	2.3	3.9	6.2	-0.9	-2.2	-2.5
Body Mass Index (BMI) (2010)	2.2	3.0	3.2	1.6	1.8	1.7
Lung FVC	2.2	11.0	13.7	-2.5	-3.6	-3.7
Hair/balding pattern: Pattern 2	2.2	2.8	3.2	-1.8	-1.4	-1.7
Forced vital capacity (FVC), Best measure	2.2	8.0	9.5	-2.4	-3.1	-3.0
Leg pain on walking	2.2	2.8	3.2	1.7	1.8	1.5
Coronary Artery Disease (CAD)	2.1	2.5	4.0	0.6	1.7	2.0
Maternal smoking around birth	2.1	3.1	6.4	2.5	1.4	1.0
Waist circumference	2.1	7.7	8.5	2.9	2.8	2.6
Medication: Seretide 50 evohaler	2.1	2.4	4.4	2.1	1.5	0.8
Neck or shoulder pain in last month	2.0	2.9	4.0	1.0	1.9	2.0
Pack years of smoking	2.0	3.0	5.5	0.7	1.7	2.4
Medication for cholesterol	1.9	2.9	6.1	-2.5	-1.3	-0.9
Back pain experienced in last month	1.9	2.8	4.0	1.0	1.9	2.0
Commuting to job workplace: Public transport	1.8	2.2	2.3	1.5	1.5	1.4
Alzheimer’s Disease (including proxy)	1.7	2.4	4.0	1.1	1.5	2.0
Ulcerative Colitis (UC)	1.7	3.1	3.6	-1.8	-1.9	-1.6
Hypothyroidism (self reported)	1.7	3.9	6.4	2.5	1.8	1.4
Qualifications: CSEs or equivalent	1.7	2.3	2.9	1.4	1.4	1.7
Financial difficulties in last 2 years	1.7	2.3	3.0	1.2	1.6	1.7
Hip circumference	1.7	7.2	7.5	2.7	2.6	2.7
Leg fat percentage (right)	1.7	6.1	6.9	2.6	2.5	2.3
Number of operations (self-reported)	1.7	2.5	2.8	1.7	1.5	1.6
Leg fat mass (left)	1.7	6.5	8.0	2.8	2.5	2.3
BMI	1.6	9.2	11.3	3.4	2.9	2.8
Average weekly spirits intake	1.6	2.0	3.0	-1.7	-1.4	-1.0
Heart attack	1.6	2.1	3.1	1.8	1.4	1.0
Arm fat percentage (right)	1.6	6.4	7.7	2.8	2.5	2.3
Medication: Ventolin 100micrograms inhaler	1.6	2.1	2.9	1.1	1.7	1.5
Alzheimer’s Disease (in father)	1.5	1.6	3.0	0.5	1.3	1.7
Pack years adult smoking proportion	1.5	2.2	4.6	0.3	1.4	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	1.9	3.4	-0.2	1.5	1.8
Had other major operations	1.5	1.8	2.3	1.0	1.5	1.5
Forced vital capacity (FVC)	1.5	5.9	7.0	-2.3	-2.7	-2.3
Illnesses of mother	1.5	1.8	1.9	-1.4	-1.3	-1.4
Hair/balding pattern: Pattern 4	1.5	3.6	4.4	2.1	1.9	1.7
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	4.8	2.2	1.6	1.2
Wheeze or whistling in the chest in last year	1.5	2.8	4.2	2.1	1.7	1.1
Health satisfaction	1.5	1.9	2.3	1.2	1.5	1.4
Heart disease (mother)	1.5	1.8	2.5	1.6	1.2	1.2
Number of full sisters	1.5	1.8	3.0	1.7	1.3	0.8
Supplements: Vitamin C	1.5	1.8	2.2	-1.5	-1.4	-1.1
Chronic bronchitis/emphysema (father)	1.4	1.7	2.5	1.2	1.0	1.6
Arm fat mass (right)	1.4	5.9	7.6	2.7	2.3	2.3
Headache pain in last month	1.4	2.4	3.7	0.3	1.8	1.9
Arm fat percentage (left)	1.4	5.8	7.0	2.6	2.4	2.2
Impedance of whole body	1.4	7.0	11.0	-3.3	-2.3	-2.1
Schizophrenia (2018)	1.3	2.7	3.4	1.8	1.7	1.4
Stomach or abdominal pain in last month	1.3	1.7	2.5	1.6	1.2	1.1
Had menopause	1.3	1.6	2.9	-0.8	-1.1	-1.7
Prospective memory result	1.3	1.6	2.2	1.0	1.5	1.3
Leg fat mass (right)	1.3	5.1	6.2	2.5	2.2	2.0
Illnesses of father: None of the above (group 1)	1.3	1.6	2.9	-1.7	-1.0	-1.0
Arm fat mass (left)	1.3	5.3	6.4	2.5	2.2	2.2
Depressed Affect (Nagel 2018)	1.2	2.5	4.5	0.7	1.6	2.1
Schizophrenia (2014)	1.2	2.6	4.6	2.1	1.3	1.2
Smoking Status	1.2	3.0	3.9	2.0	1.9	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.2	0.6	1.6	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	1.7	-1.0	-1.3	-1.2
Impedance of arm (left)	1.2	5.7	8.1	-2.9	-2.1	-2.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.5	0.3	1.2	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.0	-0.7	-1.2	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.3	-0.3	1.4	1.5
Number of self-reported non-cancer illnesses	1.2	2.1	2.4	1.5	1.3	1.5
Unable to work because of sickness or disability	1.2	1.6	2.2	1.5	1.3	1.0
Heart attack/myocardial infarction (self-reported)	1.2	1.5	2.4	1.5	1.2	0.8
Alzheimer’s Disease (in mother)	1.1	1.3	2.1	0.9	1.0	1.4
Ulcerative Colitis	1.1	1.6	2.1	-1.5	-1.3	-1.0
Ever had hysterectomy (womb removed)	1.1	1.2	1.7	1.1	1.3	0.9
Medication: Co-codamol	1.1	1.3	1.8	-1.3	-1.0	-1.1
Impedance of leg (right)	1.1	5.2	8.4	-2.9	-2.0	-1.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.8	-1.3	-0.9	-1.2
Impedance of arm (right)	1.1	5.2	7.3	-2.7	-2.1	-2.0
Birth weight of first child	1.1	2.0	2.6	-1.6	-1.4	-1.2
Loud music exposure frequency	1.1	1.2	3.3	1.8	0.5	-0.0
Medication: Amlodipine	1.1	1.5	1.5	1.2	1.2	1.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.4	1.8	0.7	0.1
Body fat percentage	1.1	4.4	5.0	2.2	2.0	2.0
Whole body fat mass	1.1	4.4	5.0	2.2	2.0	2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	2.9	-1.7	-1.6	-1.0
Diabetes diagnosed by doctor	1.1	1.8	4.0	2.0	0.9	0.7
Osteoarthritis (self-reported)	1.1	1.4	2.5	1.6	1.0	0.9
Mother’s age at death	1.1	1.4	2.4	-1.6	-1.0	-1.0
Crohns Disease (2012)	1.0	1.7	1.7	1.3	1.3	1.3
Neuroticism (2016)	1.0	1.5	3.0	0.5	1.1	1.7
Weight	1.0	4.9	5.8	2.4	2.1	2.2
Noisy workplace	1.0	1.3	1.4	1.2	1.0	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	4.2	-1.7	-2.1	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.1	-0.9	0.8	1.5
Supplements: Calcium	1.0	1.1	1.6	0.4	1.2	1.3
Primary Biliary Cirrhosis	0.9	1.3	1.7	1.3	1.1	1.0
Neuroticism	0.9	2.1	3.7	0.7	1.5	1.9
Severe depression (siblings)	0.9	1.0	2.6	-1.6	-0.5	-0.3
Average weekly fortified wine intake	0.9	1.1	1.6	-1.3	-0.7	-1.0
Medication: Levothyroxine sodium	0.9	1.6	2.4	1.5	1.1	1.1
Mood swings	0.9	1.7	3.1	0.6	1.3	1.8
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	-0.5	-0.9	-1.4
Medication: Metformin	0.8	1.1	1.8	1.4	0.9	0.8
High blood pressure (siblings)	0.8	1.1	1.3	1.1	0.9	1.1
Eye problems/disorders: Cataract	0.8	0.9	1.0	-1.0	-0.9	-1.0
Smoking status: Current	0.8	1.3	2.7	0.7	1.6	0.9
Average weekly beer plus cider intake	0.8	1.1	1.3	-1.1	-1.1	-0.9
Risk taking	0.8	1.2	2.1	0.0	1.2	1.5
Irritable Bowel Disease (IBD)	0.7	1.6	1.9	-1.1	-1.4	-1.2
Diabetes (father)	0.7	0.8	1.3	-0.4	-1.0	-1.1
Current tobacco smoking	0.7	1.1	2.3	0.5	1.5	0.9
Supplements: Glucosamine	0.7	0.9	1.1	-0.8	-1.1	-1.0
Impedance of leg (left)	0.7	3.3	5.3	-2.3	-1.6	-1.5
Trunk fat mass	0.7	3.1	3.3	1.8	1.7	1.8
Alcohol usually taken with meals	0.7	1.2	1.5	0.7	1.2	1.2
Nervous feelings	0.7	1.3	1.6	-1.0	-1.1	-1.3
Pain all over the body in last month	0.7	0.7	1.8	-1.3	-0.5	-0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	3.3	-1.7	-1.8	-1.2
Pulse rate	0.7	1.2	1.4	1.0	1.2	1.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.3	-0.7	-1.2	-0.9
Mean time to correctly identify matches	0.7	1.3	1.7	1.3	1.0	1.1
Had major operations	0.7	0.8	1.3	0.8	0.8	1.1
Medication: Aspirin	0.7	0.9	1.1	0.9	1.0	1.1
Wears glasses or contact lenses	0.7	0.8	1.6	-0.3	-0.8	-1.3
Medication: Blood pressure	0.7	1.3	3.1	1.7	0.7	0.7
Illnesses of father: High blood pressure	0.7	0.9	1.9	1.4	0.7	0.6
Rheumatoid Arthritis	0.6	0.8	1.9	-0.5	0.7	1.4
Triglycerides	0.6	1.0	2.6	1.6	0.6	0.4
Sensitivity / hurt feelings	0.6	1.1	2.0	0.7	0.9	1.4
Systolic blood pressure, automated reading	0.6	1.6	2.4	-1.0	-1.5	-1.2
Diabetes (mother)	0.6	0.7	0.9	0.6	0.9	1.0
Trunk fat percentage	0.6	2.2	2.4	1.5	1.4	1.5
Falls in the last year	0.6	0.9	1.2	0.4	1.1	1.1
Happiness	0.6	0.7	1.1	1.0	0.5	0.9
Breastfed as a baby	0.6	0.7	1.0	0.7	0.9	1.0
Blood clot in the leg (DVT)	0.6	0.7	2.1	1.5	0.3	-0.1
Glaucoma (self-reported)	0.6	0.8	1.0	0.5	1.0	1.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.2	-0.6	-0.9	-1.1
Medication: Aspirin	0.6	0.7	1.2	1.1	0.7	0.8
Medication: Lisinopril	0.6	0.7	1.0	-0.7	-1.0	-0.9
Fractured/broken bones in last 5 years	0.6	0.8	1.1	-1.0	-0.8	-0.9
Reaction Time	0.5	1.0	1.6	1.3	0.8	0.8
Prostate Cancer	0.5	0.6	0.8	0.6	0.8	0.9
Supplements: Zinc	0.5	0.5	0.9	0.1	0.9	0.8
Townsend deprivation index at recruitment	0.5	0.7	1.9	1.4	0.4	-0.2
Sitting height	0.5	3.5	5.0	-2.2	-1.9	-1.4
Diabetes (self-reported)	0.5	0.7	1.9	1.4	0.4	0.3
Time employed in main current job	0.5	0.6	1.5	-1.2	-0.4	-0.2
Worrier / anxious feelings	0.5	1.0	1.5	-1.2	-1.0	-0.7
Exposure to tobacco smoke at home	0.5	0.6	1.1	-0.6	-0.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.2	-1.5	-0.4	-0.1
Medication: Paracetamol	0.5	0.8	1.3	-1.1	-0.8	-0.7
Medication: Ibuprofen	0.5	0.6	1.5	-1.2	-0.6	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.7	-0.8	-0.8	-0.7
Suffer from ‘nerves’	0.5	0.9	1.3	0.9	1.1	0.6
Knee pain experienced in last month	0.5	0.8	1.7	1.3	0.5	0.7
Leg fat-free mass (right)	0.5	2.7	3.4	1.8	1.4	1.6
Asthma (self-reported)	0.5	1.0	1.6	0.4	1.2	1.3
Medication: Gliclazide	0.5	0.5	0.9	-0.3	-1.0	-0.7
Leg predicted mass (right)	0.5	2.8	3.6	1.9	1.5	1.6
Cholesterol lowering medication	0.5	0.8	1.7	1.3	0.7	0.2
Depression (Nagel 2018)	0.4	0.6	1.6	-1.3	-0.4	0.0
Major Depression (MDD)	0.4	0.5	0.8	-0.6	-0.6	-0.9
Blood Platelet Count	0.4	4.4	5.7	2.4	2.0	1.8
Blood Red Count	0.4	3.9	7.2	1.0	1.9	2.7
Waist Hip Ratio (WHR)	0.4	2.0	2.3	1.4	1.5	1.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.1	1.4	0.3	0.4
Hand grip strength (left)	0.4	1.1	1.4	-0.9	-1.2	-1.0
Hearing difficulty/problems: Yes	0.4	0.6	1.2	1.1	0.6	0.3
Relative age voice broke	0.4	0.6	1.2	-0.3	-0.7	-1.1
Multivitamins +/- minerals	0.4	0.5	1.0	-0.4	0.4	1.0
Leg predicted mass (left)	0.4	2.1	2.4	1.5	1.3	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	-1.0	-0.7	-0.2
Shortness of breath walking on level ground	0.4	0.4	0.7	0.7	0.8	0.3
Angina (self-reported)	0.4	0.5	1.1	1.0	0.4	0.6
Overall health rating	0.4	0.9	1.3	1.1	0.9	0.6
Chest pain or discomfort	0.4	0.6	0.8	0.5	0.9	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.9	0.2	0.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.3	-0.7	-1.1	-0.9
Basal metabolic rate	0.4	2.4	2.7	1.6	1.4	1.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	1.2	-0.0	-0.5
Arm predicted mass (left)	0.4	2.1	2.6	1.6	1.2	1.5
Neuroticism (Nagel 2018)	0.3	0.7	1.5	-0.0	0.7	1.2
Height	0.3	5.5	8.5	-2.9	-2.3	-1.6
Systolic Blood Pressure	0.3	1.5	2.7	-0.9	-1.6	-1.0
Chronotype (morning person)	0.3	0.7	0.7	-0.8	-0.9	-0.8
Relative age of first facial hair	0.3	0.6	0.8	-0.8	-0.7	-0.9
Angina	0.3	0.4	1.0	1.0	0.3	0.4
Medication for hormone replacement therapy	0.3	0.3	0.8	0.9	-0.1	-0.4
Leg fat-free mass (left)	0.3	1.6	2.0	1.4	1.1	1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.0	0.1	0.8	1.0
Allergy	0.3	0.6	0.8	-0.6	-0.9	-0.8
Neuroticism score	0.3	0.6	1.3	-0.1	0.7	1.1
Trunk fat-free mass	0.3	1.5	1.7	1.3	1.1	1.3
Father’s age at death	0.3	0.4	0.5	-0.5	-0.7	-0.7
Trunk predicted mass	0.3	1.5	1.7	1.3	1.1	1.3
Standing height	0.3	3.2	5.2	-2.3	-1.8	-1.1
Tense / ‘highly strung’	0.3	0.5	0.9	0.9	0.4	0.7
Peak expiratory flow (PEF)	0.3	0.7	1.8	-0.5	0.4	1.3
Pulse wave reflection index	0.3	0.4	0.6	-0.5	-0.8	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	0.7	0.9	0.5
Number of full brothers	0.3	0.4	0.9	0.9	0.5	0.3
Number of children fathered	0.3	0.4	0.5	0.6	0.7	0.5
Age at first live birth	0.3	0.6	1.0	-0.4	-1.0	-0.8
Whole body fat-free mass	0.3	1.9	2.2	1.4	1.2	1.5
Ever had bowel cancer screening	0.3	0.3	0.6	0.1	-0.6	-0.8
Friendships satisfaction	0.3	0.4	1.0	0.3	0.3	1.0
Osteoporosis (self-reported)	0.3	0.4	1.0	1.0	0.2	-0.2
Whole body water mass	0.3	1.9	2.2	1.4	1.2	1.5
Arm fat-free mass (left)	0.3	1.5	1.8	1.3	1.0	1.3
Irritability	0.3	0.5	0.9	0.0	0.7	0.9
Myopia	0.3	0.4	0.5	-0.6	-0.7	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.8	-0.6	-0.2
Age at First Birth	0.2	0.3	0.7	0.4	-0.2	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.2	0.4	0.7
Respiratory disease	0.2	0.3	0.5	-0.3	0.7	0.7
Tanning	0.2	2.3	3.0	-1.1	-1.6	-1.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	-0.8	-0.3	0.0
Vitamin and mineral supplements	0.2	0.3	0.7	0.4	-0.2	-0.8
Hand grip strength (right)	0.2	0.6	0.9	-1.0	-0.9	-0.3
Fed-up feelings	0.2	0.4	0.6	-0.3	0.6	0.7
Medication: Atenolol	0.2	0.3	0.6	-0.4	-0.7	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	0.3	0.5	0.6
Medication: Simvastatin	0.2	0.3	0.4	0.7	0.6	0.5
Fluid intelligence score	0.2	0.4	0.8	-0.4	0.5	0.9
Illnesses of siblings	0.2	0.2	0.3	-0.6	-0.3	-0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.2	0.6	0.6
Asthma	0.2	0.4	0.6	-0.3	0.6	0.8
Depression (self-reported)	0.2	0.2	0.3	0.4	0.4	0.5
Lung cancer (father)	0.2	0.2	0.4	-0.2	0.5	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	-0.6	0.5	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	0.2	0.3	0.9
Gout (self-reported)	0.2	0.2	0.4	-0.7	-0.3	-0.3
Arm fat-free mass (right)	0.2	1.1	1.3	1.1	0.9	1.1
Qualifications: College or University degree	0.2	0.6	1.7	-1.3	-0.3	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.5	0.6	-0.2
Migraine (self-reported)	0.2	0.3	0.4	-0.6	-0.3	-0.6
Medication: Allopurinol	0.2	0.3	0.7	-0.8	-0.2	0.3
Arm predicted mass (right)	0.2	1.2	1.5	1.1	0.9	1.2
Pulse rate, automated reading	0.2	0.6	0.8	-0.9	-0.7	-0.7
Comparative height size at age 10	0.2	1.3	2.5	-0.5	1.1	1.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.4	0.0	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.4	0.4	0.6
Illnesses of father: Heart disease	0.2	0.2	0.4	0.3	0.4	0.7
Smoking status: Previous	0.2	0.2	0.6	0.8	-0.1	-0.2
Mineral and other dietary supplements	0.2	0.2	0.4	0.2	-0.5	-0.6
Miserableness	0.2	0.4	0.8	-0.4	0.6	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.7	0.2	0.3
Financial situation satisfaction	0.2	0.2	0.5	0.7	0.2	-0.0
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	-0.5	-0.4	-0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.1	0.5	0.7
Medication: Atorvastatin	0.2	0.3	0.6	0.8	0.1	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	-0.6	-0.5	-0.3
Age started oral contraceptive pill	0.2	0.2	0.3	0.6	0.4	-0.4
Ever depressed for a whole week	0.2	0.2	0.3	0.4	-0.4	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.4	-1.2	-0.2	-0.4
Heart disease (siblings)	0.2	0.3	0.4	0.5	0.4	0.6
Worry (Nagel 2018)	0.1	0.2	0.5	-0.7	0.1	0.3
Crohns Disease (2017)	0.1	0.2	0.3	0.2	-0.5	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.3	0.1	-0.6	0.0
Mean Putamen Volume	0.1	0.1	0.2	0.3	0.3	0.4
Fasting Glucose	0.1	0.1	0.3	0.1	-0.3	-0.5
HbA1C	0.1	0.1	0.1	-0.4	-0.4	-0.3
HDL Cholesterol	0.1	0.1	0.2	-0.4	0.2	0.4
LDL Cholesterol	0.1	0.2	0.5	0.0	-0.4	-0.7
Blood Eosinophil Count	0.1	0.9	1.7	1.3	1.0	0.4
Allergy or Eczema	0.1	0.1	0.2	-0.4	0.3	0.5
Hair Pigment	0.1	3.1	6.0	-2.5	-1.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.5	-0.1	0.0
Taking other prescription medications	0.1	0.2	0.2	0.5	0.5	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.5	-0.1	-0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.3	0.3	0.2
Number of incorrect matches in round	0.1	0.1	0.2	-0.2	-0.5	-0.3
Past tobacco smoking	0.1	0.2	0.5	-0.7	-0.1	0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.5	-0.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	-0.3	-0.3	-0.5
Qualifications: None of the above	0.1	0.3	0.8	0.2	-0.4	-0.9
Mouth/teeth dental problems	0.1	0.1	0.3	0.3	0.2	0.5
Medication: Ramipril	0.1	0.1	0.2	-0.0	0.3	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.2	0.5	0.4	0.4
Number of live births	0.1	0.1	0.1	0.4	0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.3	0.0	-0.5	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.7	0.5	0.0
Worry too long after embarrassment	0.1	0.2	0.3	-0.6	-0.5	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.0	0.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.3	0.1	0.3
Pulse wave peak to peak time	0.1	0.1	0.2	-0.4	-0.1	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	-0.1	0.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	0.4	0.1	-0.3
Alcohol intake frequency.	0.1	0.3	0.6	0.8	0.2	0.4
Family relationship satisfaction	0.1	0.2	0.3	-0.4	-0.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.1	-0.4	-0.4
Hypertension (Self-reported)	0.1	0.2	0.3	0.5	-0.5	-0.3
Average weekly red wine intake	0.1	0.1	0.2	0.5	0.3	0.3
Qualifications: nursing, teaching	0.1	0.1	0.2	0.5	0.1	-0.2
Breast cancer (self-reported)	0.1	0.2	0.4	0.7	-0.2	-0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.1	0.4	0.4
Guilty feelings	0.1	0.1	0.2	0.3	0.3	0.5
Hearing aid user	0.1	0.1	0.2	-0.3	-0.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.1	0.4	0.4
High cholesterol (Self-reported)	0.1	0.2	0.4	0.0	-0.4	-0.6
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.0	-0.6	-0.3
Ever smoked	0.1	0.1	0.3	-0.1	-0.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.5	0.2	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.3	-0.4	-0.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	0.3	0.0	-0.4
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	0.1	-0.1	0.5
Breast Cancer	0.0	0.1	0.2	0.4	0.0	-0.2
Lupus	0.0	0.0	0.1	0.3	-0.2	0.2
Heel T-Score	0.0	0.1	0.3	-0.1	-0.6	-0.3
Cardiovascular Disease	0.0	0.2	0.4	0.6	-0.3	0.1
Number of treatments/medications taken	0.0	0.0	0.1	0.2	0.0	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	0.2	0.2	0.0
High blood pressure	0.0	0.1	0.3	0.5	-0.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	-0.4	-0.1	0.1
Medication: Cholesterol lowering	0.0	0.0	0.1	0.3	0.0	0.1
Medication: Lansoprazole	0.0	0.0	0.0	-0.2	-0.0	0.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	0.2	-0.1	0.1
Length of working week for main job	0.0	0.0	0.0	-0.1	0.1	-0.1
Birth weight	0.0	0.1	0.2	0.4	0.1	0.3
Medication: Blood pressure	0.0	0.0	0.1	0.1	-0.3	-0.1
Medication: Omeprazole	0.0	0.0	0.0	0.1	0.1	0.2
Age at last live birth	0.0	0.0	0.1	0.0	0.2	0.1
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.0	0.3	-0.2
Medication: Paracetamol	0.0	0.0	0.0	-0.2	-0.1	-0.0
Alcohol drinker status: Never	0.0	0.0	0.0	-0.1	0.1	0.0
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.4	-0.1	0.3

Hub : Genes

PAN3-AS1

Models

Trait associations