[Hub]/) : Traits : Comparative body size at age 10 :

chr12:48,605,088-51,365,312

Best TWAS P=9.46e-58 · Best GWAS P=4.07e-82 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAIM2 0.09 0.00 bslmm 336 0.03 3.7e-04 1.02 8.7 3.3e-18 0.52 0.06 0.79 TRUE
2 CommonMind Brain Pre-frontal Cortex RHEBL1 0.03 0.01 blup 315 0.02 4.4e-03 6.23 7.8 7.9e-15 0.15 0.09 0.62 FALSE
3 CommonMind Brain Pre-frontal Cortex TUBA1A 0.08 0.06 lasso 4 0.06 1.8e-07 8.02 -8.5 1.5e-17 -0.05 0.04 0.96 FALSE
4 CommonMind Brain Pre-frontal Cortex TUBA1B 0.08 0.06 lasso 7 0.06 4.6e-08 7.05 -7.7 1.1e-14 -0.04 0.08 0.92 FALSE
5 CommonMind Brain Pre-frontal Cortex TUBA1C 0.41 0.54 lasso 5 0.54 3.0e-77 7.57 7.5 5.8e-14 0.02 0.13 0.87 FALSE
6 GTEx Adipose Subcutaneous LMBR1L 0.12 0.09 lasso 6 0.08 1.9e-07 7.89 -7.8 5.8e-15 -0.05 0.01 0.99 FALSE
7 GTEx Adipose Visceral Omentum LMBR1L 0.09 0.03 lasso 6 0.01 7.4e-02 7.99 -7.8 4.2e-15 -0.03 0.03 0.90 FALSE
8 GTEx Artery Aorta CCDC65 0.19 0.08 enet 7 0.11 1.9e-06 2.77 5.6 2.5e-08 0.14 0.91 0.06 TRUE
9 GTEx Artery Aorta RP11-302B13.1 0.16 0.04 enet 13 0.08 2.9e-05 1.88 -5.9 3.6e-09 -0.02 0.03 0.94 FALSE
10 GTEx Artery Aorta RP11-302B13.5 0.13 0.07 lasso 6 0.06 2.0e-04 7.85 -8.1 6.2e-16 -0.03 0.01 0.96 FALSE
11 GTEx Artery Tibial CCDC65 0.14 0.08 enet 39 0.11 7.9e-09 6.15 5.8 6.8e-09 0.08 0.79 0.20 FALSE
12 GTEx Artery Tibial LMBR1L 0.07 0.04 enet 13 0.03 1.7e-03 8.11 -7.6 2.4e-14 -0.02 0.02 0.98 TRUE
13 GTEx Artery Tibial RP4-605O3.4 0.04 0.01 lasso 4 0.00 3.2e-01 -5.24 -5.6 2.0e-08 0.00 0.24 0.04 FALSE
14 GTEx Brain Caudate basal ganglia LIMA1 0.18 0.12 lasso 5 0.07 3.9e-03 -5.85 -5.7 9.4e-09 -0.01 0.15 0.10 FALSE
15 GTEx Brain Cerebellum LMBR1L 0.18 0.15 lasso 1 0.12 1.9e-04 7.89 -7.9 3.0e-15 -0.02 0.01 0.95 FALSE
16 GTEx Brain Cortex CERS5 0.26 0.09 enet 30 0.11 5.9e-04 1.41 -7.6 4.2e-14 -0.28 0.29 0.04 TRUE
17 GTEx Breast Mammary Tissue LMBR1L 0.09 0.02 enet 19 0.01 5.5e-02 7.93 -6.2 4.0e-10 -0.07 0.02 0.88 FALSE
18 GTEx Breast Mammary Tissue (Female) CERS5 0.09 0.03 lasso 3 0.05 1.8e-02 1.70 -12.7 9.7e-37 -0.53 0.05 0.22 TRUE
19 GTEx Cells Transformed fibroblasts LIMA1 0.17 0.01 lasso 6 0.02 8.8e-03 0.65 5.3 1.1e-07 0.21 0.14 0.08 TRUE
20 GTEx Cells Transformed fibroblasts SMARCD1 0.08 0.07 enet 5 0.07 9.3e-06 -5.44 5.6 2.1e-08 0.01 0.99 0.00 FALSE
21 GTEx Esophagus Mucosa CERS5 0.08 0.00 enet 23 0.01 6.4e-02 1.95 5.4 6.0e-08 0.23 0.25 0.28 TRUE
22 GTEx Esophagus Mucosa LMBR1L 0.07 0.03 lasso 5 0.04 1.8e-03 6.59 -8.0 9.1e-16 -0.09 0.02 0.94 FALSE
23 GTEx Esophagus Mucosa RP11-386G11.10 0.10 0.02 enet 23 0.05 2.0e-04 7.05 -5.4 7.0e-08 0.05 0.14 0.72 TRUE
24 GTEx Esophagus Muscularis TUBA1B 0.08 0.04 lasso 7 0.06 1.9e-04 7.05 -7.8 8.3e-15 -0.05 0.04 0.89 FALSE
25 GTEx Esophagus Muscularis RP11-386G11.10 0.10 0.11 lasso 7 0.10 1.0e-06 7.05 -7.6 3.9e-14 -0.04 0.06 0.94 TRUE
26 GTEx Lung LMBR1L 0.05 0.02 lasso 2 0.00 1.5e-01 6.59 -7.4 1.1e-13 -0.07 0.04 0.80 TRUE
27 GTEx Muscle Skeletal RP11-386G11.5 0.09 0.07 enet 17 0.08 7.4e-08 6.13 -6.9 4.5e-12 -0.11 0.99 0.01 FALSE
28 GTEx Nerve Tibial LMBR1L 0.08 0.04 lasso 4 0.06 3.1e-05 6.19 -7.8 6.1e-15 -0.05 0.04 0.95 TRUE
29 GTEx Nerve Tibial RP11-386G11.10 0.07 0.05 lasso 2 0.03 1.8e-03 7.89 -7.9 2.9e-15 -0.02 0.01 0.97 FALSE
30 GTEx Pituitary RP11-386G11.10 0.19 0.11 lasso 5 0.10 1.4e-03 6.18 -7.3 2.5e-13 -0.09 0.06 0.59 FALSE
31 GTEx Skin Sun Exposed Lower leg SMARCD1 0.07 0.02 lasso 2 0.03 1.4e-03 3.92 5.1 2.7e-07 0.01 0.30 0.04 FALSE
32 GTEx Skin Sun Exposed Lower leg LMBR1L 0.15 0.10 lasso 3 0.09 3.1e-08 7.93 -8.1 7.4e-16 -0.03 0.01 0.99 FALSE
33 GTEx Skin Sun Exposed Lower leg TUBA1C 0.07 0.03 lasso 3 0.05 2.7e-05 5.48 -6.9 4.2e-12 -0.16 0.40 0.52 FALSE
34 GTEx Skin Sun Exposed Lower leg RP11-386G11.10 0.08 0.00 enet 18 0.01 3.1e-02 7.25 -5.2 2.7e-07 -0.09 0.02 0.55 TRUE
35 GTEx Skin Sun Exposed Lower leg RP11-161H23.5 0.06 0.03 enet 4 0.05 7.3e-05 6.18 -7.1 1.2e-12 -0.16 0.16 0.75 FALSE
36 GTEx Spleen LMBR1L 0.30 0.30 enet 11 0.30 2.4e-08 7.99 -8.8 1.9e-18 -0.09 0.01 0.98 TRUE
37 GTEx Testis SMARCD1 0.22 0.10 enet 22 0.10 2.6e-05 -5.22 7.0 2.2e-12 0.09 0.74 0.03 TRUE
38 GTEx Testis TUBA1B 0.21 0.28 lasso 9 0.26 7.0e-12 8.11 -8.1 5.8e-16 -0.03 0.01 0.99 FALSE
39 GTEx Testis FAIM2 0.27 0.09 lasso 5 0.06 9.3e-04 16.92 -16.0 9.5e-58 -0.77 0.05 0.84 TRUE
40 GTEx Testis CERS5 0.12 0.06 lasso 6 0.07 4.0e-04 -5.51 -5.4 8.4e-08 0.02 0.19 0.06 FALSE
41 GTEx Testis LMBR1L 0.13 0.11 lasso 3 0.12 4.1e-06 7.05 -7.6 3.0e-14 -0.01 0.02 0.98 FALSE
42 GTEx Testis PRKAG1 0.17 0.11 lasso 5 0.09 1.2e-04 6.59 -6.9 7.1e-12 -0.06 0.30 0.64 FALSE
43 GTEx Testis RP11-386G11.10 0.25 0.33 lasso 9 0.32 1.3e-14 8.11 -8.0 1.7e-15 -0.02 0.01 0.99 FALSE
44 GTEx Thyroid LIMA1 0.08 0.06 enet 18 0.06 1.7e-05 -4.58 -5.4 5.6e-08 -0.14 0.32 0.05 FALSE
45 GTEx Thyroid SPATS2 0.16 0.04 enet 25 0.05 1.5e-04 3.68 -6.0 2.7e-09 -0.34 0.97 0.00 FALSE
46 GTEx Thyroid LMBR1L 0.12 0.10 lasso 3 0.10 6.4e-08 7.93 -8.1 8.3e-16 -0.03 0.01 0.99 FALSE
47 GTEx Whole Blood RP4-605O3.4 0.04 0.04 lasso 4 0.01 1.5e-02 -5.21 -5.5 5.1e-08 0.00 0.28 0.03 FALSE
48 METSIM Adipose LMBR1L 0.05 0.03 blup 303 0.03 5.2e-06 7.93 -8.0 1.0e-15 -0.03 0.01 0.99 FALSE
49 NTR Blood BCDIN3D 0.02 0.00 blup 331 0.00 8.2e-03 3.29 -7.7 1.4e-14 -0.41 0.03 0.18 FALSE
50 NTR Blood KCNH3 0.03 0.00 bslmm 307 0.00 9.8e-03 2.00 -5.9 4.6e-09 -0.32 0.05 0.09 FALSE
51 YFS Blood TUBA1B 0.02 0.02 lasso 8 0.02 2.7e-08 7.05 8.4 4.9e-17 0.09 0.22 0.78 FALSE
52 The Cancer Genome Atlas Breast Invasive Carcinoma FAIM2 0.02 0.00 blup 71 0.01 8.5e-03 1.02 -8.3 6.6e-17 -0.36 0.16 0.12 TRUE
53 The Cancer Genome Atlas Breast Invasive Carcinoma SMARCD1 0.02 0.03 lasso 1 0.03 3.7e-06 -5.81 5.8 6.3e-09 0.02 0.01 0.99 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma TUBA1C 0.12 0.10 lasso 4 0.10 1.2e-11 7.00 7.0 3.0e-12 0.00 0.01 0.99 FALSE
55 The Cancer Genome Atlas Lung Adenocarcinoma TUBA1C 0.03 0.04 lasso 2 0.03 7.7e-05 6.88 -6.4 1.8e-10 -0.23 0.04 0.84 FALSE
56 The Cancer Genome Atlas Prostate Adenocarcinoma TUBA1C 0.04 0.02 blup 37 0.04 2.3e-05 6.88 8.1 8.6e-16 0.19 0.02 0.96 TRUE
57 The Cancer Genome Atlas Rectum Adenocarcinoma SMARCD1 0.40 0.04 blup 48 0.14 4.1e-04 -5.85 5.2 1.6e-07 0.05 0.01 0.69 FALSE
58 The Cancer Genome Atlas Thyroid Carcinoma FAIM2 0.14 0.04 blup 69 0.07 1.2e-07 -1.28 6.7 2.2e-11 0.29 0.99 0.00 TRUE
59 The Cancer Genome Atlas Thyroid Carcinoma LMBR1L 0.03 0.01 blup 24 0.01 1.8e-02 7.99 -7.0 1.9e-12 -0.01 0.01 0.80 FALSE