Best TWAS P=5.27e-13 · Best GWAS P=1.38e-12 conditioned to 7e-04
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | LEPR | 0.46 | 0.19 | lasso | 9 | 0.25 | 1.0e-08 | 6.6 | 7.2 | 5.3e-13 | 0.61 | 0.11 | 0.79 | TRUE |
| 2 | YFS | Blood | LEPROT | 0.40 | 0.25 | enet | 52 | 0.38 | 2.0e-133 | -4.4 | 5.3 | 1.2e-07 | 0.25 | 1.00 | 0.00 | FALSE |
| 3 | The Cancer Genome Atlas | Colon Adenocarcinoma | LEPR | 0.22 | 0.02 | blup | 142 | 0.07 | 1.1e-04 | 7.0 | 5.1 | 2.8e-07 | 0.43 | 0.01 | 0.88 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LEPR | 0.13 | 0.02 | blup | 142 | 0.07 | 3.9e-08 | -6.0 | 5.5 | 3.0e-08 | 0.44 | 0.02 | 0.95 | FALSE |