TWAS
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Models
Genes
Traits
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Traits
:
Comparative body size at age 10
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chr1:65,189,751-66,803,080
Best TWAS P=5.27e-13 · Best GWAS P=1.38e-12 conditioned to 7e-04
65.2M
65.4M
65.6M
65.8M
66M
66.2M
66.4M
66.6M
66.8M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells EBV-transformed lymphocytes
LEPR
0.46
0.19
lasso
9
0.25
1.0e-08
6.6
7.2
5.3e-13
0.61
0.11
0.79
TRUE
4
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
LEPR
0.13
0.02
blup
142
0.07
3.9e-08
-6.0
5.5
3.0e-08
0.44
0.02
0.95
FALSE
2
YFS
Blood
LEPROT
0.40
0.25
enet
52
0.38
2.0e-133
-4.4
5.3
1.2e-07
0.25
1.00
0.00
FALSE
3
The Cancer Genome Atlas
Colon Adenocarcinoma
LEPR
0.22
0.02
blup
142
0.07
1.1e-04
7.0
5.1
2.8e-07
0.43
0.01
0.88
FALSE