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chr19:18,451,661-20,313,262

Best TWAS P=1.67e-10 · Best GWAS P=7.65e-10 conditioned to 3.16e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	ROSMAP	Brain Pre-frontal Cortex	HAPLN4	0.05	0.03	enet	15	0.03	1.7e-04	-5.5	-6.4	1.7e-10	-0.01	0.09	0.90	TRUE
2	GTEx	Artery Tibial	MEF2B	0.11	0.02	enet	9	0.06	2.6e-05	-3.0	5.2	2.3e-07	0.04	0.72	0.15	TRUE
3	GTEx	Brain Cerebellum	ARMC6	0.28	0.00	enet	43	0.13	1.5e-04	3.9	-5.8	6.8e-09	-0.19	0.05	0.54	FALSE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAPLN4	0.07	0.05	lasso	7	0.07	2.9e-08	-4.9	-5.7	1.2e-08	-0.03	0.03	0.97	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	HAPLN4	0.10	0.08	blup	38	0.11	8.5e-07	-5.6	-5.6	1.8e-08	-0.03	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GATAD2A	0.13	0.30	lasso	7	0.29	2.4e-35	-5.4	5.6	2.2e-08	0.04	0.07	0.93	FALSE
9	The Cancer Genome Atlas	Colon Adenocarcinoma	GATAD2A	0.04	0.03	blup	61	0.05	1.3e-03	-5.1	-5.6	2.5e-08	-0.05	0.03	0.82	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSSK6	0.02	0.02	blup	33	0.02	1.8e-03	-5.1	-5.6	2.6e-08	-0.05	0.01	0.81	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA0892	0.03	0.01	lasso	7	0.02	6.3e-03	-5.5	5.5	3.3e-08	0.03	0.01	0.84	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	HAPLN4	0.08	0.06	blup	37	0.09	1.8e-09	-5.3	-5.4	6.2e-08	-0.04	0.01	0.99	FALSE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GATAD2A	0.02	0.02	lasso	1	0.02	2.1e-03	-5.3	-5.3	9.2e-08	-0.05	0.02	0.72	FALSE
4	GTEx	Muscle Skeletal	SUGP1	0.11	0.06	lasso	7	0.07	9.5e-08	-4.7	5.3	1.1e-07	0.03	0.24	0.76	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAPLN4	0.05	0.07	lasso	2	0.06	1.1e-07	-5.5	-5.3	1.2e-07	-0.04	0.01	0.99	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAPLN4	0.04	0.07	lasso	4	0.06	1.3e-12	-4.8	-5.3	1.4e-07	-0.02	0.31	0.69	FALSE
7	YFS	Blood	GATAD2A	0.09	0.14	blup	365	0.14	7.5e-44	-5.1	-5.2	1.6e-07	-0.04	0.09	0.90	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA0892	0.04	0.04	blup	43	0.02	4.1e-03	-5.5	5.2	1.6e-07	0.05	0.01	0.98	FALSE
5	GTEx	Whole Blood	TMEM161A	0.06	0.00	enet	2	0.00	1.4e-01	-5.2	5.2	2.2e-07	0.04	0.04	0.80	FALSE