[Hub]/) : Traits : Comparative height size at age 10 : ← →

chr17:17,051,974-18,923,818

Best TWAS P=1.95e-15 · Best GWAS P=1.92e-14 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
60	METSIM	Adipose	SHMT1	0.12	0.02	bslmm	259	0.03	5.4e-05	7.6	-7.9	2.0e-15	-0.71	0.00	1.00	TRUE
31	GTEx	Esophagus Muscularis	CTD-2303H24.2	0.25	0.09	lasso	5	0.16	8.4e-10	-6.9	7.5	5.1e-14	0.84	0.01	0.99	TRUE
15	GTEx	Brain Cortex	TOP3A	0.21	0.13	enet	11	0.09	1.8e-03	6.4	6.9	4.1e-12	0.68	0.05	0.64	TRUE
86	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SHMT1	0.07	0.03	enet	6	0.05	2.5e-06	7.7	-6.9	4.2e-12	-0.91	0.00	1.00	TRUE
97	The Cancer Genome Atlas	Stomach Adenocarcinoma	SHMT1	0.17	0.10	lasso	2	0.08	1.0e-06	6.9	-6.6	4.7e-11	-0.79	0.31	0.67	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CCDC144B	0.21	0.05	enet	30	0.16	1.5e-18	7.5	5.5	4.0e-08	0.65	0.01	0.99	TRUE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYO15A	0.04	0.02	lasso	3	0.02	2.5e-03	5.3	-5.2	1.7e-07	-0.54	0.07	0.20	TRUE
54	GTEx	Thyroid	CTD-2303H24.2	0.20	0.14	enet	8	0.13	1.9e-10	7.6	7.9	2.2e-15	0.88	0.00	1.00	FALSE
6	GTEx	Adipose Visceral Omentum	CTD-2303H24.2	0.35	0.10	enet	14	0.23	2.8e-12	5.2	7.9	3.2e-15	0.84	0.03	0.97	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	SHMT1	0.04	0.05	lasso	3	0.04	9.2e-06	7.5	-7.8	8.7e-15	-0.97	0.00	1.00	FALSE
13	GTEx	Brain Cerebellum	TOP3A	0.22	0.09	lasso	5	0.15	3.0e-05	7.0	7.8	9.3e-15	0.91	0.01	0.98	FALSE
59	METSIM	Adipose	LGALS9C	0.07	0.06	lasso	6	0.05	6.5e-08	7.6	7.7	1.1e-14	0.93	0.00	1.00	FALSE
26	GTEx	Colon Transverse	CTD-2303H24.2	0.08	0.08	lasso	4	0.04	5.9e-03	-6.9	7.7	1.6e-14	0.89	0.02	0.94	FALSE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	SHMT1	0.06	0.05	blup	33	0.05	8.2e-11	7.6	-7.6	2.3e-14	-0.93	0.00	1.00	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	CTD-2303H24.2	0.27	0.08	lasso	5	0.17	1.6e-09	7.6	7.6	2.5e-14	0.87	0.00	1.00	FALSE
35	GTEx	Heart Left Ventricle	CTD-2303H24.2	0.24	0.04	lasso	6	0.10	4.3e-06	5.2	7.6	3.5e-14	0.82	0.02	0.98	FALSE
23	GTEx	Cells Transformed fibroblasts	CTD-2303H24.2	0.29	0.10	lasso	3	0.12	5.8e-09	7.6	7.5	5.7e-14	0.93	0.00	1.00	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SHMT1	0.12	0.06	blup	32	0.07	1.6e-08	7.0	-7.5	5.8e-14	-0.89	0.01	0.99	FALSE
33	GTEx	Heart Atrial Appendage	SHMT1	0.12	0.06	lasso	4	0.06	1.1e-03	7.5	-7.4	1.2e-13	-0.96	0.01	0.97	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	CTD-2303H24.2	0.33	0.20	lasso	3	0.34	6.0e-13	-6.9	7.3	2.0e-13	0.72	0.20	0.79	FALSE
25	GTEx	Colon Sigmoid	CTD-2303H24.2	0.55	0.33	enet	37	0.30	4.2e-11	-6.9	7.3	2.5e-13	0.73	0.26	0.74	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	SHMT1	0.38	0.26	lasso	10	0.24	2.7e-08	6.9	-7.3	3.1e-13	-0.83	0.03	0.96	FALSE
29	GTEx	Esophagus Mucosa	CTD-2303H24.2	0.21	0.09	enet	29	0.17	2.4e-11	-6.9	7.3	3.4e-13	0.72	0.19	0.81	FALSE
90	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SHMT1	0.19	0.13	blup	40	0.11	3.1e-05	7.0	-7.1	9.3e-13	-0.84	0.01	0.97	FALSE
4	GTEx	Adipose Subcutaneous	SHMT1	0.20	0.07	lasso	9	0.04	1.4e-04	7.0	-7.1	1.0e-12	-0.79	0.10	0.88	FALSE
11	GTEx	Artery Tibial	CTD-2303H24.2	0.32	0.17	lasso	7	0.23	7.1e-18	7.6	7.1	1.1e-12	0.89	0.00	1.00	FALSE
58	METSIM	Adipose	FAM106A	0.20	0.13	enet	21	0.15	5.8e-22	7.7	7.1	1.6e-12	0.88	0.00	1.00	FALSE
43	GTEx	Pituitary	CTD-2303H24.2	0.27	0.04	lasso	8	0.08	4.1e-03	7.6	7.0	2.1e-12	0.79	0.02	0.66	FALSE
94	The Cancer Genome Atlas	Rectum Adenocarcinoma	SHMT1	0.49	0.16	lasso	5	0.11	1.9e-03	7.7	-7.0	2.1e-12	-0.96	0.00	0.79	FALSE
57	GTEx	Whole Blood	CTD-2303H24.2	0.04	0.02	lasso	4	0.04	8.4e-05	5.2	7.0	2.3e-12	0.78	0.02	0.96	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	USP32P2	0.74	0.61	enet	18	0.65	4.4e-110	-6.9	7.0	3.1e-12	0.71	0.32	0.68	FALSE
5	GTEx	Adipose Subcutaneous	CTD-2303H24.2	0.16	0.11	enet	15	0.18	2.4e-14	-6.9	6.9	4.4e-12	0.79	0.02	0.98	FALSE
38	GTEx	Muscle Skeletal	SHMT1	0.16	0.08	lasso	5	0.13	1.0e-12	7.7	-6.9	5.1e-12	-0.89	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SHMT1	0.06	0.07	lasso	2	0.06	8.3e-06	6.9	-6.9	5.1e-12	-0.80	0.07	0.92	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SHMT1	0.22	0.14	enet	16	0.17	5.5e-20	7.7	-6.9	5.3e-12	-0.87	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SHMT1	0.20	0.18	lasso	5	0.16	3.2e-08	7.0	-6.9	6.1e-12	-0.79	0.07	0.93	FALSE
46	GTEx	Small Intestine Terminal Ileum	TOP3A	0.25	0.09	lasso	5	0.06	1.8e-02	6.8	6.8	7.2e-12	0.78	0.03	0.72	FALSE
45	GTEx	Skin Sun Exposed Lower leg	CTD-2303H24.2	0.24	0.08	enet	20	0.13	3.9e-11	7.6	6.8	8.0e-12	0.81	0.00	1.00	FALSE
14	GTEx	Brain Cerebellum	CTD-2303H24.2	0.46	0.15	lasso	5	0.12	2.8e-04	7.6	6.8	8.6e-12	0.85	0.00	0.97	FALSE
95	The Cancer Genome Atlas	Soft Tissue Sarcoma	SHMT1	0.07	0.06	lasso	5	0.05	5.5e-04	6.9	-6.8	8.7e-12	-0.80	0.02	0.84	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EVPLL	0.04	0.00	blup	22	0.00	2.8e-01	7.7	6.8	9.5e-12	0.78	0.00	0.64	FALSE
65	YFS	Blood	SHMT1	0.46	0.28	bslmm	255	0.41	7.3e-145	7.6	-6.8	1.4e-11	-0.81	0.00	1.00	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SMCR8	0.04	0.00	blup	33	0.00	2.0e-01	7.0	-6.8	1.4e-11	-0.75	0.00	0.42	FALSE
28	GTEx	Esophagus Mucosa	TOP3A	0.08	0.04	enet	10	0.05	4.1e-04	4.6	6.7	1.9e-11	0.70	0.03	0.92	FALSE
37	GTEx	Lung	CTD-2303H24.2	0.45	0.12	lasso	6	0.27	1.3e-20	7.6	6.7	2.9e-11	0.78	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	SHMT1	0.06	0.02	blup	32	0.04	9.4e-06	7.0	-6.6	3.9e-11	-0.79	0.01	0.98	FALSE
50	GTEx	Testis	SHMT1	0.28	0.05	enet	20	0.12	7.6e-06	-3.5	6.6	4.0e-11	0.63	0.04	0.72	FALSE
30	GTEx	Esophagus Muscularis	SHMT1	0.28	0.21	lasso	5	0.34	2.3e-21	7.7	-6.6	4.4e-11	-0.89	0.00	1.00	FALSE
34	GTEx	Heart Atrial Appendage	CTD-2303H24.2	0.26	0.11	lasso	6	0.13	1.5e-06	-6.9	6.4	1.2e-10	0.77	0.01	0.98	FALSE
17	GTEx	Brain Hippocampus	RP11-815I9.4	0.18	0.05	lasso	4	0.08	7.3e-03	6.8	6.4	1.4e-10	0.71	0.04	0.54	FALSE
42	GTEx	Nerve Tibial	CTD-2303H24.2	0.23	0.08	enet	15	0.18	9.4e-13	-6.9	6.4	1.9e-10	0.75	0.03	0.97	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	TOP3A	0.15	0.09	lasso	7	0.14	2.8e-17	6.7	6.4	1.9e-10	0.64	0.66	0.34	FALSE
10	GTEx	Artery Tibial	SHMT1	0.49	0.29	lasso	6	0.44	4.0e-38	-3.4	-6.3	2.2e-10	-0.87	0.00	1.00	FALSE
32	GTEx	Heart Atrial Appendage	TOM1L2	0.12	0.04	enet	2	0.04	7.0e-03	6.3	-6.3	2.4e-10	-0.57	0.17	0.48	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLII	0.04	0.02	blup	48	0.03	2.2e-03	5.6	-6.3	2.5e-10	-0.69	0.02	0.68	FALSE
41	GTEx	Nerve Tibial	TOP3A	0.35	0.21	lasso	12	0.18	1.1e-12	6.9	6.3	2.6e-10	0.82	0.22	0.78	FALSE
24	GTEx	Colon Sigmoid	TOP3A	0.51	0.08	lasso	15	0.16	2.9e-06	6.9	6.3	2.8e-10	0.64	0.13	0.63	FALSE
52	GTEx	Testis	CTD-2303H24.2	0.50	0.26	lasso	17	0.36	1.1e-16	-6.9	6.3	3.0e-10	0.74	0.06	0.94	FALSE
85	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLII	0.03	0.01	lasso	4	0.00	8.4e-02	5.0	-6.3	3.4e-10	-0.67	0.01	0.53	FALSE
7	GTEx	Artery Aorta	SHMT1	0.35	0.20	enet	23	0.31	1.3e-17	-3.4	-6.3	3.9e-10	-0.82	0.03	0.97	FALSE
48	GTEx	Spleen	CTD-2303H24.2	0.32	0.02	enet	15	0.12	5.2e-04	5.2	6.2	5.1e-10	0.65	0.07	0.51	FALSE
20	GTEx	Breast Mammary Tissue (Female)	CTD-2303H24.2	0.41	0.02	enet	30	0.14	7.5e-05	-6.9	6.2	5.7e-10	0.67	0.04	0.59	FALSE
40	GTEx	Nerve Tibial	SHMT1	0.30	0.20	lasso	6	0.29	5.5e-21	-3.4	-6.1	8.5e-10	-0.79	0.28	0.72	FALSE
18	GTEx	Breast Mammary Tissue	CTD-2303H24.2	0.32	0.07	enet	34	0.15	5.3e-08	7.6	6.1	8.8e-10	0.75	0.01	0.98	FALSE
9	GTEx	Artery Coronary	CTD-2303H24.2	0.38	0.04	lasso	7	0.20	3.8e-07	7.6	6.1	1.0e-09	0.80	0.01	0.98	FALSE
89	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SHMT1	0.12	0.08	enet	5	0.07	8.8e-04	7.0	-6.1	1.4e-09	-0.74	0.02	0.58	FALSE
22	GTEx	Cells Transformed fibroblasts	SHMT1	0.42	0.27	lasso	7	0.39	2.7e-31	-3.4	-6.0	1.5e-09	-0.80	0.78	0.22	FALSE
88	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TOP3A	0.08	0.00	blup	48	0.01	1.6e-02	-3.6	-5.9	3.2e-09	-0.65	0.01	0.51	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMCR7	0.07	0.04	blup	33	0.03	3.0e-04	5.3	-5.9	3.3e-09	-0.57	0.10	0.52	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLII	0.08	0.02	enet	6	0.04	1.9e-05	-3.6	-5.8	5.0e-09	-0.59	0.03	0.81	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	FLII	0.04	0.01	blup	47	0.03	5.1e-04	5.3	-5.8	5.6e-09	-0.60	0.04	0.72	FALSE
8	GTEx	Artery Aorta	CTD-2303H24.2	0.39	0.12	enet	37	0.27	3.7e-15	-6.9	5.8	5.9e-09	0.64	0.06	0.94	FALSE
69	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TOP3A	0.05	0.01	blup	53	0.02	1.0e-02	-3.7	-5.8	6.2e-09	-0.59	0.02	0.69	FALSE
91	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMCR7	0.13	0.05	enet	11	0.08	4.3e-04	-3.5	-5.8	6.3e-09	-0.57	0.03	0.61	FALSE
19	GTEx	Breast Mammary Tissue (Male)	CTD-2303H24.2	0.27	0.00	enet	33	0.01	1.5e-01	7.6	5.8	6.4e-09	0.69	0.03	0.44	FALSE
39	GTEx	Muscle Skeletal	CTD-2303H24.2	0.23	0.11	enet	23	0.17	5.2e-16	-6.9	5.8	6.4e-09	0.69	0.18	0.82	FALSE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	SMCR8	0.06	0.01	enet	9	0.03	3.3e-04	-3.8	-5.8	6.7e-09	-0.62	0.01	0.71	FALSE
36	GTEx	Lung	SHMT1	0.15	0.13	lasso	6	0.16	2.4e-12	-3.3	-5.7	1.0e-08	-0.71	0.14	0.86	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF286B	0.07	0.02	enet	7	0.02	5.6e-03	-6.9	-5.7	1.4e-08	-0.44	0.00	0.68	FALSE
96	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLII	0.05	0.04	blup	47	0.03	1.7e-03	5.3	-5.7	1.4e-08	-0.58	0.04	0.25	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOP3A	0.05	0.02	enet	8	0.03	1.2e-07	-3.8	-5.7	1.6e-08	-0.57	0.59	0.28	FALSE
98	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ALKBH5	0.11	0.03	blup	64	0.04	1.8e-02	-2.4	-5.6	2.1e-08	-0.48	0.02	0.47	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMCR7	0.04	0.01	blup	34	0.02	1.0e-03	-3.7	-5.6	2.2e-08	-0.56	0.03	0.65	FALSE
49	GTEx	Stomach	SHMT1	0.21	0.05	enet	18	0.08	1.4e-04	-3.4	-5.6	2.4e-08	-0.68	0.05	0.94	FALSE
47	GTEx	Small Intestine Terminal Ileum	CTD-2303H24.2	0.38	0.28	lasso	9	0.26	1.7e-06	5.6	5.6	2.7e-08	0.51	0.32	0.24	FALSE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	LLGL1	0.09	0.01	blup	52	0.02	1.1e-05	-2.8	-5.5	3.4e-08	-0.48	0.24	0.56	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	SHMT1	0.26	0.10	enet	38	0.09	6.8e-12	-6.9	-5.5	3.6e-08	-0.65	0.26	0.74	FALSE
12	GTEx	Brain Cerebellar Hemisphere	CTD-2303H24.2	0.53	0.08	enet	50	0.15	1.4e-04	7.6	5.5	3.8e-08	0.68	0.01	0.96	FALSE
56	GTEx	Whole Blood	SHMT1	0.28	0.11	lasso	7	0.21	9.8e-19	-3.3	-5.5	4.9e-08	-0.70	0.03	0.97	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ALKBH5	0.05	0.02	lasso	2	0.03	3.1e-03	-4.2	-5.4	5.5e-08	-0.45	0.05	0.22	FALSE
53	GTEx	Thyroid	TOP3A	0.14	0.08	lasso	3	0.09	1.5e-07	-3.3	5.4	6.5e-08	0.65	0.23	0.77	FALSE
55	GTEx	Whole Blood	CCDC144B	0.05	0.06	lasso	2	0.06	3.2e-06	-3.3	-5.4	6.9e-08	-0.74	0.02	0.95	FALSE
73	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SHMT1	0.11	0.05	lasso	3	0.04	4.0e-03	-3.4	-5.4	7.8e-08	-0.71	0.01	0.64	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MYO15A	0.17	0.12	bslmm	313	0.14	4.5e-16	4.8	-5.3	1.1e-07	-0.59	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LLGL1	0.08	0.03	blup	52	0.05	1.9e-06	-2.3	-5.3	1.1e-07	-0.48	0.47	0.51	FALSE
51	GTEx	Testis	RP11-258F1.1	0.17	0.10	lasso	3	0.10	2.9e-05	-4.2	-5.2	1.8e-07	-0.40	0.63	0.05	FALSE
16	GTEx	Brain Cortex	CTD-2303H24.2	0.34	0.08	enet	42	0.15	5.3e-05	7.7	5.2	2.4e-07	0.67	0.01	0.92	FALSE
61	NTR	Blood	SHMT1	0.03	0.01	bslmm	264	0.01	4.7e-05	6.9	-5.2	2.5e-07	-0.78	0.01	0.99	FALSE