Best TWAS P=1.72e-13 · Best GWAS P=4e-14 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF585A | 0.08 | 0.10 | lasso | 3 | 0.11 | 2.6e-13 | -5.8 | 5.5 | 4.7e-08 | -0.80 | 0.96 | 0.04 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | ZNF585B | 0.09 | 0.06 | enet | 20 | 0.09 | 2.6e-11 | -7.4 | -5.4 | 5.9e-08 | 0.83 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Subcutaneous | ZNF585A | 0.09 | 0.02 | lasso | 3 | 0.02 | 3.8e-03 | -5.1 | -5.9 | 3.7e-09 | 0.82 | 0.05 | 0.87 | FALSE |
4 | GTEx | Adipose Subcutaneous | ZNF585B | 0.10 | 0.10 | lasso | 8 | 0.12 | 1.2e-09 | 6.3 | -6.5 | 1.0e-10 | 0.90 | 0.02 | 0.98 | FALSE |
5 | GTEx | Adipose Visceral Omentum | ZNF585B | 0.06 | 0.02 | enet | 8 | 0.00 | 2.5e-01 | -7.4 | -6.9 | 3.7e-12 | 0.96 | 0.02 | 0.81 | FALSE |
6 | GTEx | Artery Aorta | ZNF829 | 0.11 | 0.04 | lasso | 2 | 0.00 | 2.5e-01 | -7.5 | 7.2 | 4.3e-13 | -0.99 | 0.02 | 0.88 | FALSE |
7 | GTEx | Artery Tibial | AC092295.7 | 0.11 | 0.01 | enet | 25 | 0.07 | 3.6e-06 | 2.2 | -5.3 | 1.0e-07 | 0.55 | 0.51 | 0.35 | FALSE |
8 | GTEx | Artery Tibial | ZNF585B | 0.17 | 0.14 | lasso | 15 | 0.22 | 5.6e-17 | -5.9 | -6.2 | 4.2e-10 | 0.88 | 0.03 | 0.97 | FALSE |
9 | GTEx | Brain Cerebellum | ZNF793 | 0.23 | 0.02 | enet | 40 | 0.07 | 4.8e-03 | -7.4 | 5.8 | 5.4e-09 | -0.77 | 0.03 | 0.73 | FALSE |
10 | GTEx | Cells EBV-transformed lymphocytes | ZNF585B | 0.13 | 0.10 | enet | 20 | 0.13 | 4.3e-05 | -7.4 | -5.8 | 7.0e-09 | 0.76 | 0.03 | 0.94 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | ZNF585B | 0.17 | 0.20 | enet | 19 | 0.22 | 1.2e-16 | -7.5 | -6.8 | 8.1e-12 | 0.93 | 0.01 | 0.99 | FALSE |
12 | GTEx | Esophagus Mucosa | ZNF585B | 0.10 | 0.04 | lasso | 4 | 0.05 | 2.2e-04 | -7.5 | -6.0 | 1.6e-09 | 0.85 | 0.02 | 0.98 | FALSE |
13 | GTEx | Esophagus Muscularis | ZNF585B | 0.14 | 0.06 | enet | 23 | 0.12 | 1.4e-07 | -2.7 | -5.7 | 1.0e-08 | 0.82 | 0.06 | 0.94 | FALSE |
14 | GTEx | Heart Atrial Appendage | ZNF850 | 0.08 | 0.03 | enet | 15 | 0.06 | 1.6e-03 | -5.4 | 5.2 | 2.5e-07 | -0.74 | 0.22 | 0.32 | FALSE |
15 | GTEx | Lung | ZNF585B | 0.06 | 0.08 | lasso | 5 | 0.07 | 7.0e-06 | 6.3 | -6.5 | 6.5e-11 | 0.91 | 0.03 | 0.97 | FALSE |
16 | GTEx | Nerve Tibial | ZNF585A | 0.06 | 0.07 | lasso | 9 | 0.06 | 6.9e-05 | -7.5 | -7.3 | 2.5e-13 | 0.99 | 0.04 | 0.96 | FALSE |
17 | GTEx | Pituitary | CTD-2630F21.1 | 0.14 | 0.02 | lasso | 7 | -0.01 | 4.6e-01 | 6.2 | -5.9 | 3.4e-09 | 0.90 | 0.03 | 0.68 | FALSE |
18 | GTEx | Spleen | ZNF585A | 0.23 | 0.10 | lasso | 8 | 0.07 | 5.9e-03 | -7.6 | -6.8 | 7.9e-12 | 0.95 | 0.02 | 0.85 | FALSE |
19 | GTEx | Stomach | ZNF585B | 0.07 | 0.07 | lasso | 5 | 0.05 | 1.4e-03 | -7.4 | -7.4 | 1.7e-13 | 0.99 | 0.02 | 0.95 | TRUE |
20 | GTEx | Thyroid | ZNF585B | 0.04 | 0.03 | lasso | 6 | 0.01 | 4.0e-02 | 6.5 | -6.2 | 4.9e-10 | 0.93 | 0.05 | 0.81 | FALSE |
21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF568 | 0.01 | 0.01 | blup | 64 | 0.01 | 1.3e-03 | -4.7 | 6.2 | 5.2e-10 | -0.87 | 0.09 | 0.68 | FALSE |
22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF585B | 0.03 | 0.02 | enet | 4 | 0.02 | 5.4e-06 | -7.6 | -5.6 | 1.9e-08 | 0.85 | 0.00 | 0.99 | FALSE |
23 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZNF585A | 0.08 | 0.06 | blup | 29 | 0.05 | 5.0e-04 | -5.8 | 5.5 | 3.6e-08 | -0.53 | 0.09 | 0.28 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF585B | 0.11 | 0.04 | blup | 33 | 0.06 | 1.3e-07 | -5.8 | -6.3 | 4.0e-10 | 0.72 | 0.01 | 0.96 | FALSE |
25 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF585B | 0.13 | 0.03 | enet | 9 | 0.08 | 1.5e-09 | -7.6 | -5.5 | 2.9e-08 | 0.80 | 0.00 | 1.00 | FALSE |
26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF585B | 0.12 | 0.04 | enet | 9 | 0.07 | 5.6e-08 | -7.6 | -5.9 | 3.3e-09 | 0.84 | 0.00 | 1.00 | FALSE |
27 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ZNF568 | 0.11 | 0.09 | blup | 63 | 0.09 | 4.1e-04 | 6.2 | 5.8 | 5.2e-09 | -0.91 | 0.04 | 0.87 | FALSE |
28 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF568 | 0.20 | 0.14 | lasso | 2 | 0.14 | 9.3e-14 | -5.4 | 5.4 | 5.9e-08 | -0.72 | 1.00 | 0.00 | FALSE |
29 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF585B | 0.07 | 0.06 | enet | 11 | 0.07 | 3.4e-07 | -5.8 | -6.1 | 1.1e-09 | 0.84 | 0.00 | 1.00 | FALSE |