Best TWAS P=3.59e-13 · Best GWAS P=1.65e-12 conditioned to 0.591
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MAU2 | 0.09 | 0.08 | blup | 369 | 0.10 | 1.0e-12 | -3.2 | 6.0 | 2.7e-09 | -0.77 | 0.16 | 0.84 | FALSE |
| 2 | GTEx | Brain Hippocampus | DDX49 | 0.23 | -0.01 | lasso | 4 | -0.01 | 6.6e-01 | -6.6 | 7.3 | 3.6e-13 | -0.93 | 0.02 | 0.69 | TRUE |
| 3 | GTEx | Esophagus Mucosa | GATAD2A | 0.11 | 0.02 | lasso | 3 | 0.02 | 2.3e-02 | -6.9 | -7.1 | 1.7e-12 | 0.93 | 0.01 | 0.91 | FALSE |
| 4 | GTEx | Muscle Skeletal | MAU2 | 0.09 | 0.04 | lasso | 4 | 0.05 | 5.1e-06 | -6.8 | 5.8 | 8.4e-09 | -0.86 | 0.05 | 0.95 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | IL12RB1 | 0.07 | 0.02 | lasso | 3 | 0.01 | 6.4e-02 | 5.0 | -5.6 | 1.8e-08 | 0.04 | 0.00 | 0.96 | TRUE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | TSSK6 | 0.07 | 0.02 | blup | 32 | 0.04 | 2.9e-03 | 2.9 | 5.6 | 2.4e-08 | -0.55 | 0.04 | 0.19 | FALSE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | JUND | 0.17 | 0.00 | blup | 57 | 0.03 | 5.4e-02 | 2.7 | 5.8 | 8.4e-09 | -0.08 | 0.00 | 0.27 | TRUE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TM6SF2 | 0.04 | 0.03 | blup | 35 | 0.03 | 2.5e-04 | -6.6 | -6.8 | 1.0e-11 | 0.89 | 0.01 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GATAD2A | 0.04 | 0.03 | lasso | 2 | 0.03 | 2.9e-04 | -3.4 | -5.2 | 2.5e-07 | 0.82 | 0.04 | 0.90 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | IL12RB1 | 0.08 | 0.04 | lasso | 3 | 0.05 | 8.9e-06 | 4.1 | -5.3 | 1.4e-07 | 0.08 | 0.00 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | TM6SF2 | 0.05 | 0.04 | blup | 34 | 0.05 | 2.8e-05 | -6.6 | -6.5 | 1.0e-10 | 0.91 | 0.01 | 0.99 | FALSE |