Hub : Genes

ZNF850

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.044 0.0210 0.00083 0.011 0.018 0.005 NA 0.004 0.0160 0.0025 0.0750 NA 0.10000
2 GTEx Breast Mammary Tissue 0.216 0.1080 0.00450 0.028 NA 0.020 NA -0.001 0.0140 NA 0.0310 NA 0.35000
3 GTEx Breast Mammary Tissue (Male) 0.153 0.0994 0.05400 -0.012 NA -0.009 NA -0.013 0.7400 NA 0.5800 NA 0.86000
4 GTEx Breast Mammary Tissue (Female) 0.165 0.1089 0.03800 -0.010 NA 0.036 NA -0.009 0.8600 NA 0.0300 NA 0.76000
5 GTEx Heart Atrial Appendage 0.080 0.0350 0.00160 0.026 NA 0.056 NA 0.029 0.0250 NA 0.0016 NA 0.01800
6 GTEx Skin Not Sun Exposed Suprapubic 0.101 0.0570 0.00850 -0.001 NA 0.003 NA -0.005 0.3500 NA 0.2000 NA 0.84000
7 GTEx Spleen 0.336 0.1210 0.00100 0.099 NA 0.104 NA 0.142 0.0016 NA 0.0013 NA 0.00017

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.6 1.8 1.3 -0.9 0.0 0.0 -0.3 0.7 -0.9
Bipolar Disorder or Schizophrenia 0.3 0.8 3.3 1.8 -1.3 0.0 0.0 -0.7 0.6 -0.0
Depressed Affect (Nagel 2018) 0.3 0.7 3.8 -0.1 0.1 0.0 0.0 -0.2 -1.9 -1.0
Depression (Nagel 2018) 0.3 0.5 1.4 -1.2 -0.7 0.0 0.0 -0.9 -0.3 -0.8
Intelligence (Savage-Jansen 2018) 2.2 6.8 33.9 -1.4 -2.6 0.0 0.0 -2.2 -0.1 -5.8
Neuroticism (Nagel 2018) 0.3 0.6 3.5 0.5 -0.5 0.0 0.0 0.6 -1.9 0.1
Schizophrenia (2018) 0.2 0.5 1.6 1.3 -0.9 0.0 0.0 -0.6 0.2 0.7
Schizophrenia vs Biploar Disorder 0.4 0.6 2.4 0.7 0.6 0.0 0.0 0.4 -1.5 0.8
Worry (Nagel 2018) 0.4 0.8 3.0 0.8 -1.1 0.0 0.0 1.0 -1.7 0.0
Alzheimer’s Disease (in mother) 0.6 0.7 2.6 1.2 -0.1 0.0 0.0 1.0 -0.2 -1.6
Alzheimer’s Disease (in father) 0.3 0.3 1.0 -1.0 -0.3 0.0 0.0 -0.9 0.1 -0.6
Alzheimer’s Disease (including proxy) 0.4 0.6 3.6 0.6 -0.3 0.0 0.0 -0.1 0.3 -1.9
Crohns Disease (2017) 2.7 5.9 24.4 1.5 4.9 0.0 0.0 3.8 -0.5 -0.2
Irritable Bowel Disease (IBD) 1.1 2.6 7.3 0.7 2.7 0.0 0.0 2.4 -1.9 -0.8
Ulcerative Colitis (UC) 0.4 0.7 4.6 0.2 -0.1 0.0 0.0 0.1 -2.1 -0.8
Major Depression (MDD) 0.7 0.9 4.4 -2.1 -1.1 0.0 0.0 -0.5 -0.3 -0.3
Reaction Time 1.8 3.3 13.0 -2.5 -2.0 0.0 0.0 -3.6 -0.7 -0.1
Verbal and Numeric Reasoning (VNR) 1.9 4.6 19.8 -1.0 -2.6 0.0 0.0 -2.1 0.4 -4.5
Breast Cancer 0.7 1.7 6.9 -2.6 -0.8 0.0 0.0 -1.9 0.8 -0.2
Ovarian Cancer 1.7 2.2 8.7 0.1 1.5 0.0 0.0 2.1 0.2 2.9
Prostate Cancer 0.8 1.1 4.6 1.6 -0.7 0.0 0.0 0.5 0.5 2.1
Age at First Birth 0.3 0.5 1.7 -0.3 1.3 0.0 0.0 0.9 -0.2 -0.9
Bipolar Disorder (2011) 1.5 1.4 4.7 0.5 -1.2 0.0 0.0 -1.8 2.2 -0.6
Body Mass Index (BMI) (2010) 0.2 0.3 1.5 -0.1 -0.5 0.0 0.0 -1.2 0.1 0.6
Coronary Artery Disease (CAD) 0.8 1.0 3.3 -0.7 -0.1 0.0 0.0 -1.8 -1.7 -0.7
Crohns Disease (2012) 2.4 3.8 17.9 1.9 4.2 0.0 0.0 2.2 -0.6 -0.6
Mean Putamen Volume 0.4 0.5 1.8 0.2 -0.2 0.0 0.0 -1.3 -1.2 -0.4
Fasting Glucose 0.4 0.5 1.1 1.0 0.1 0.0 0.0 -0.9 -0.7 -1.0
HbA1C 1.8 2.0 6.4 1.5 2.5 0.0 0.0 1.4 -0.2 1.8
HDL Cholesterol 0.5 0.8 3.5 0.6 1.2 0.0 0.0 1.9 0.5 0.5
LDL Cholesterol 0.1 0.1 0.5 -0.7 -0.3 0.0 0.0 -0.5 -0.3 0.2
Lupus 0.7 1.1 5.3 -0.4 -0.5 0.0 0.0 -0.6 -2.3 -1.2
Neuroticism (2016) 0.3 0.4 1.6 -0.6 -0.8 0.0 0.0 0.0 -1.3 0.5
Primary Biliary Cirrhosis 3.8 5.5 11.0 3.2 2.8 0.0 0.0 3.3 -1.1 2.8
Rheumatoid Arthritis 1.0 1.4 4.8 -1.2 1.3 0.0 0.0 -2.2 1.4 0.3
Schizophrenia (2014) 0.2 0.5 3.1 1.8 -0.2 0.0 0.0 0.2 0.4 0.4
Triglycerides 0.1 0.2 0.4 -0.5 -0.7 0.0 0.0 -0.6 0.0 0.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 3.7 1.1 -0.4 0.0 0.0 0.8 -1.9 -0.8
Ulcerative Colitis 0.5 0.7 4.8 0.0 0.2 0.0 0.0 0.0 -2.2 0.6
Blood Eosinophil Count 1.3 9.9 29.4 4.0 3.1 0.0 0.0 5.4 -3.8 0.4
Blood Platelet Count 0.6 6.8 29.1 1.2 -3.5 0.0 0.0 -5.4 0.7 -2.0
Blood Red Count 0.2 1.8 8.2 -2.9 0.7 0.0 0.0 -2.0 -0.2 0.2
Blood White Count 0.4 2.8 8.0 -0.5 -1.6 0.0 0.0 -2.8 2.3 -1.8
Heel T-Score 0.4 2.8 8.8 -0.8 -3.0 0.0 0.0 -0.6 -1.4 -2.8
BMI 0.4 2.4 11.1 -0.9 -1.7 0.0 0.0 -3.3 0.8 -1.3
Height 1.5 28.3 71.9 7.2 3.9 0.0 0.0 8.5 -7.7 -0.9
Waist Hip Ratio (WHR) 0.8 3.5 10.0 -2.3 0.9 0.0 0.0 -1.7 2.3 3.2
Systolic Blood Pressure 0.8 4.2 12.0 1.3 3.5 0.0 0.0 2.2 -3.2 -0.5
Smoking Status 0.6 1.4 3.4 0.6 1.8 0.0 0.0 1.3 1.2 1.7
Allergy or Eczema 0.7 1.9 5.6 0.8 1.6 0.0 0.0 2.4 -0.1 2.2
Cardiovascular Disease 0.4 1.2 3.8 -1.1 2.0 0.0 0.0 0.1 -1.8 0.0
Hypothyroidism (self reported) 0.6 1.4 8.9 -3.0 0.7 0.0 0.0 0.3 -0.0 0.4
Respiratory disease 0.9 1.9 9.7 -0.5 3.1 0.0 0.0 1.7 -0.6 -0.2
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.9 -2.0 1.4 0.0 0.0 0.1 0.5 1.3
Lung FEV1/FVC ratio 2.0 10.0 34.6 -0.5 -4.4 0.0 0.0 -5.9 -1.0 -3.9
Lung FVC 0.5 2.4 13.0 -0.5 0.8 0.0 0.0 0.7 3.6 1.6
Neuroticism 0.5 1.2 6.5 0.8 -1.1 0.0 0.0 0.1 -2.5 -0.4
Chronotype (morning person) 1.2 2.9 6.5 1.7 2.3 0.0 0.0 2.2 0.7 2.6
Hair Pigment 0.1 4.1 15.5 2.1 1.9 0.0 0.0 3.9 0.2 2.2
Tanning 0.2 2.9 9.5 -0.4 -2.7 0.0 0.0 -1.6 3.1 -0.8
Hand grip strength (left) 2.4 6.2 22.9 3.4 2.6 0.0 0.0 4.8 -1.0 -1.0
Number of treatments/medications taken 0.8 1.5 6.9 -2.6 1.9 0.0 0.0 -0.1 -0.1 0.3
Average weekly spirits intake 0.5 0.6 3.0 -0.3 0.8 0.0 0.0 1.7 -0.2 -0.6
Sensitivity / hurt feelings 0.6 1.1 4.4 -1.0 -2.1 0.0 0.0 -1.5 -0.0 -0.0
Frequency of depressed mood in last 2 weeks 1.0 1.5 3.8 -1.9 -1.2 0.0 0.0 -0.8 -1.6 -1.3
Hearing difficulty/problems: Yes 1.1 1.7 4.7 -1.5 -0.3 0.0 0.0 -2.1 2.2 0.7
Relative age of first facial hair 0.4 0.9 2.9 -1.1 1.1 0.0 0.0 0.9 1.7 -0.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.9 -0.8 0.4 0.0 0.0 -1.0 -0.3 -0.5
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.4 -0.3 -0.4 0.0 0.0 0.0 -1.2 -0.7
Ever had hysterectomy (womb removed) 0.2 0.2 0.8 -0.1 -0.6 0.0 0.0 0.0 0.6 -0.9
Systolic blood pressure, automated reading 0.5 1.4 5.6 0.5 2.4 0.0 0.0 0.9 -1.6 0.6
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.7 0.2 0.5 0.0 0.0 -0.1 0.8 0.8
Angina 1.2 1.6 3.4 -0.9 -1.3 0.0 0.0 -1.3 1.8 -1.8
Medication for hormone replacement therapy 0.2 0.2 0.9 -0.1 -0.3 0.0 0.0 -0.4 0.2 0.9
Vitamin and mineral supplements 2.7 3.6 12.4 3.5 1.1 0.0 0.0 2.6 -2.2 0.4
Supplements: Zinc 0.7 0.8 3.2 -1.4 -0.3 0.0 0.0 0.4 -0.2 -1.8
Medication: Co-codamol 0.3 0.4 2.2 -0.5 0.4 0.0 0.0 -0.4 1.5 0.1
Medication: Metformin 0.9 1.3 4.4 -1.6 1.2 0.0 0.0 0.1 0.7 2.1
Diabetes (father) 0.5 0.6 2.9 -0.3 -0.0 0.0 0.0 0.9 -0.8 1.7
Diabetes (mother) 0.3 0.4 2.2 0.4 0.0 0.0 0.0 1.5 -0.9 0.1
Severe depression (siblings) 1.3 1.5 3.5 -1.9 -1.5 0.0 0.0 -0.7 -1.2 -1.7
Pack years adult smoking proportion 0.4 0.6 1.4 -0.7 -1.2 0.0 0.0 -1.1 0.8 0.7
Impedance of leg (right) 0.2 0.8 2.4 -1.5 0.5 0.0 0.0 1.3 0.5 1.1
Leg fat-free mass (left) 0.3 1.7 6.3 1.7 -0.5 0.0 0.0 -0.3 -2.5 -1.4
Trunk fat percentage 0.6 2.4 7.9 -2.8 -0.6 0.0 0.0 -2.6 1.2 -0.5
Hand grip strength (right) 2.2 6.1 19.7 4.4 1.9 0.0 0.0 4.2 -0.9 -0.8
Townsend deprivation index at recruitment 0.7 1.0 4.8 1.0 -0.4 0.0 0.0 2.2 0.9 -0.5
Current tobacco smoking 0.7 1.2 3.9 -0.8 -1.0 0.0 0.0 -1.4 2.0 0.8
Average weekly fortified wine intake 0.6 0.7 4.0 0.2 0.1 0.0 0.0 0.2 2.0 0.7
Maternal smoking around birth 1.3 1.9 4.9 -1.9 -1.6 0.0 0.0 -2.2 0.5 -1.4
Fed-up feelings 1.0 1.8 5.6 -1.4 -0.7 0.0 0.0 -0.9 -1.9 -2.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.4 -1.3 -1.6 0.0 0.0 -0.9 -0.8 -1.3
Relative age voice broke 0.7 1.1 4.1 -1.2 -0.0 0.0 0.0 -1.3 2.0 0.6
Taking other prescription medications 0.6 1.0 3.5 -1.9 1.0 0.0 0.0 -0.3 -1.4 0.4
Age when periods started (menarche) 0.8 1.9 3.5 -0.8 1.9 0.0 0.0 -1.9 1.6 1.8
Bilateral oophorectomy (both ovaries removed) 0.1 0.2 0.5 0.1 0.0 0.0 0.0 -0.5 -0.7 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 2.7 0.8 -1.6 0.0 0.0 0.8 0.5 1.3
Tinnitus: Yes, but not now, but have in the past 2.6 2.7 5.1 -1.8 -2.2 0.0 0.0 -2.2 -1.2 -2.1
Qualifications: CSEs or equivalent 1.3 1.7 7.1 -1.0 0.1 0.0 0.0 -2.7 1.1 1.5
Serious illness, injury or assault to yourself 0.1 0.1 0.8 -0.1 0.4 0.0 0.0 -0.9 0.1 -0.2
High blood pressure 0.5 1.4 4.4 -1.1 2.1 0.0 0.0 0.1 -2.1 -0.2
Hayfever, allergic rhinitis or eczema 0.7 1.6 5.6 1.2 1.3 0.0 0.0 2.4 -0.4 1.5
Multivitamins +/- minerals 3.3 4.2 11.1 -2.9 -1.5 0.0 0.0 -3.3 2.9 -0.1
Stomach or abdominal pain in last month 0.5 0.6 3.5 -0.7 -0.3 0.0 0.0 0.2 -1.9 0.1
Supplements: Glucosamine 0.7 0.9 3.4 -1.8 -1.1 0.0 0.0 -1.1 0.5 -0.3
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 6.2 -0.7 -0.9 0.0 0.0 -0.4 -2.5 -1.0
Medication: Atenolol 0.2 0.2 1.1 -0.3 -0.5 0.0 0.0 0.1 0.4 -1.1
Medication: Levothyroxine sodium 0.7 1.2 4.2 -2.1 1.5 0.0 0.0 -1.1 -0.4 0.7
Sitting height 1.1 7.9 27.4 1.7 1.6 0.0 0.0 5.2 -4.6 -1.3
Chronic bronchitis/emphysema (father) 0.5 0.6 1.8 -0.2 1.3 0.0 0.0 -0.1 1.2 1.0
High blood pressure (mother) 1.3 1.8 8.1 -0.4 0.4 0.0 0.0 0.1 -2.9 -1.9
Body mass index (BMI) 0.6 2.7 11.1 -1.1 -1.8 0.0 0.0 -3.3 0.7 -1.6
Impedance of leg (left) 0.3 1.4 3.7 -1.9 1.2 0.0 0.0 1.4 0.5 1.6
Leg predicted mass (left) 0.3 1.7 6.6 1.7 -0.6 0.0 0.0 -0.3 -2.6 -1.5
Trunk fat mass 0.3 1.2 4.2 -1.9 -0.5 0.0 0.0 -2.0 0.1 -0.8
Waist circumference 0.6 2.3 8.8 -2.4 -1.0 0.0 0.0 -3.0 0.7 0.4
Number of incorrect matches in round 0.9 1.4 6.6 -1.3 0.9 0.0 0.0 2.6 -0.5 0.9
Past tobacco smoking 1.5 2.7 7.3 -0.1 -2.7 0.0 0.0 -2.4 -0.7 -2.4
Alcohol usually taken with meals 0.8 1.3 6.4 0.2 -0.0 0.0 0.0 1.6 -2.5 -0.7
Nervous feelings 0.4 0.7 3.9 0.5 0.4 0.0 0.0 2.0 -0.9 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.3 3.8 -1.4 -1.1 0.0 0.0 -1.4 -1.9 -0.7
Hearing difficulty/problems with background noise 0.2 0.4 2.5 -0.1 -0.0 0.0 0.0 0.1 1.6 0.3
Hair/balding pattern: Pattern 2 0.9 1.1 5.6 -0.2 -1.2 0.0 0.0 -0.9 -2.4 -0.5
Had menopause 1.0 1.2 7.5 -0.2 0.5 0.0 0.0 0.6 -2.7 -0.7
Had other major operations 0.3 0.4 1.2 -1.1 0.4 0.0 0.0 -0.9 -0.9 -0.1
Forced vital capacity (FVC) 0.5 2.0 5.0 2.2 1.6 0.0 0.0 2.2 -0.1 1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 2.7 0.5 -1.6 0.0 0.0 0.7 0.4 1.0
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 7.2 -0.6 -2.7 0.0 0.0 -1.8 -0.2 -2.5
Qualifications: None of the above 0.4 0.8 4.1 1.0 -0.2 0.0 0.0 0.6 0.3 2.0
Financial difficulties in last 2 years 0.8 1.1 5.7 -0.9 0.1 0.0 0.0 -2.4 -0.9 -0.3
Mouth/teeth dental problems 0.5 0.7 3.6 -0.2 -1.2 0.0 0.0 -0.2 -0.1 -1.9
Heart attack 0.2 0.2 1.1 -0.4 -1.1 0.0 0.0 -0.7 0.1 0.1
Allergy 0.3 0.6 1.7 -0.1 -1.0 0.0 0.0 -1.3 -0.2 -1.2
Pain all over the body in last month 0.2 0.2 0.7 0.3 -0.8 0.0 0.0 -0.7 -0.5 0.4
Diabetes (self-reported) 0.4 0.6 1.9 -1.0 1.0 0.0 0.0 0.1 0.7 1.4
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.8 -0.9 0.2 0.0 0.0 0.8 -2.0 -0.0
Medication: Ramipril 0.8 1.0 3.1 -1.8 0.1 0.0 0.0 -1.5 -0.3 -1.4
Medication: Simvastatin 0.6 0.9 2.4 -1.0 1.6 0.0 0.0 -0.6 1.2 1.1
Fluid intelligence score 1.6 3.3 13.0 -1.2 -2.5 0.0 0.0 -1.5 -0.4 -3.6
Illnesses of siblings 0.4 0.5 2.0 1.4 -0.5 0.0 0.0 0.4 0.9 0.5
Neuroticism score 0.6 1.3 7.5 0.7 -0.9 0.0 0.0 0.4 -2.7 -0.6
Weight 0.2 0.9 2.4 0.1 -0.8 0.0 0.0 -1.1 -1.5 -1.6
Impedance of arm (right) 0.2 0.9 2.7 -1.6 0.6 0.0 0.0 1.5 0.4 0.8
Arm fat percentage (right) 0.9 3.6 12.3 -2.4 -1.9 0.0 0.0 -3.5 1.1 -1.5
Trunk fat-free mass 0.7 3.9 15.1 2.7 -0.4 0.0 0.0 0.9 -3.9 -1.9
Hip circumference 0.2 0.9 2.1 -0.8 -0.3 0.0 0.0 -1.4 -1.4 -1.3
Time employed in main current job 1.1 1.3 5.6 -1.0 2.4 0.0 0.0 0.3 1.4 0.6
Alcohol intake versus 10 years previously 0.3 0.5 1.5 -0.9 1.2 0.0 0.0 -0.7 0.5 0.7
Father’s age at death 0.7 0.9 3.0 1.7 -0.8 0.0 0.0 1.4 -0.8 0.3
Worrier / anxious feelings 0.3 0.6 2.8 0.2 -0.0 0.0 0.0 -0.9 -1.7 0.7
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.5 6.7 -1.9 -1.9 0.0 0.0 -2.6 -1.7 -1.0
Falls in the last year 2.0 2.8 8.0 -1.1 -2.8 0.0 0.0 -2.7 1.2 -1.1
Hair/balding pattern: Pattern 3 0.9 1.3 3.7 -1.3 -0.5 0.0 0.0 -1.7 1.9 -0.8
Number of live births 1.0 1.5 5.5 -1.1 -1.3 0.0 0.0 -2.3 -1.4 -0.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.9 1.4 -0.5 0.0 0.0 0.2 -0.3 -0.5
Pulse rate 0.5 0.9 2.5 -0.6 1.6 0.0 0.0 0.3 -1.4 1.2
Happiness 1.3 1.6 6.5 0.6 0.1 0.0 0.0 1.4 -2.5 -1.6
Noisy workplace 0.8 0.9 3.5 -1.3 0.9 0.0 0.0 -0.8 1.9 0.3
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 0.2 -0.2 0.0 0.0 0.7 -0.6 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.4 0.3 1.2 0.0 0.0 -0.6 -0.4 -0.8
Mouth/teeth dental problems: Dentures 0.2 0.3 1.8 -0.5 0.2 0.0 0.0 -0.2 1.3 0.1
Asthma 0.6 1.2 6.0 -0.0 2.5 0.0 0.0 1.2 -1.0 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.5 -0.6 -1.6 0.0 0.0 -1.1 -0.9 -1.5
Medication: Cholesterol lowering 0.0 0.0 0.1 0.1 0.3 0.0 0.0 -0.0 -0.1 0.3
Depression (self-reported) 0.5 0.6 3.1 -0.3 -1.8 0.0 0.0 0.3 0.3 0.7
Medication: Lansoprazole 0.6 0.7 3.0 -1.7 0.1 0.0 0.0 -0.6 0.5 1.0
Prospective memory result 0.5 0.6 2.7 -0.3 0.6 0.0 0.0 -0.7 1.6 0.8
Lung cancer (father) 1.9 2.2 6.4 -0.1 -2.5 0.0 0.0 -2.1 -0.2 -2.1
Illnesses of mother 0.7 0.9 2.7 -0.1 -1.4 0.0 0.0 -1.1 1.6 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.9 1.4 -0.7 0.0 0.0 0.6 -0.6 -0.6
Pulse wave Arterial Stiffness index 0.5 0.6 3.0 -1.7 0.8 0.0 0.0 -0.8 0.2 0.4
Impedance of arm (left) 0.3 1.5 3.7 -1.9 1.3 0.0 0.0 1.7 0.7 1.4
Arm fat mass (right) 0.5 2.2 8.2 -1.2 -1.7 0.0 0.0 -2.9 0.3 -1.7
Trunk predicted mass 0.7 4.0 15.1 2.7 -0.4 0.0 0.0 0.9 -3.9 -2.1
Standing height 0.8 8.3 22.8 2.8 2.2 0.0 0.0 4.8 -4.7 -0.3
Length of working week for main job 1.0 1.1 4.0 -1.3 -0.2 0.0 0.0 -2.0 1.1 -0.6
Exposure to tobacco smoke at home 0.2 0.2 0.7 -0.4 -0.3 0.0 0.0 -0.8 -0.7 0.5
Breastfed as a baby 0.4 0.5 1.8 1.3 -0.0 0.0 0.0 0.3 1.2 -0.1
Tense / ‘highly strung’ 0.6 0.9 4.2 0.8 -0.2 0.0 0.0 2.1 -1.2 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 5.8 0.7 -2.4 0.0 0.0 -0.5 0.2 -1.3
Hair/balding pattern: Pattern 4 0.0 0.0 0.3 -0.1 0.5 0.0 0.0 0.2 -0.1 0.1
Birth weight of first child 0.8 1.4 4.5 2.1 0.7 0.0 0.0 1.2 -0.1 -1.9
Peak expiratory flow (PEF) 0.3 0.7 2.8 0.5 1.1 0.0 0.0 1.7 -0.7 0.5
Pulse wave reflection index 2.6 3.2 7.6 -2.4 -1.5 0.0 0.0 -2.6 2.7 0.3
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.5 -0.0 -0.1 0.0 0.0 -0.9 -1.2 0.3
Loud music exposure frequency 0.1 0.1 0.3 0.3 0.0 0.0 0.0 -0.6 -0.2 0.6
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 1.0 -0.2 -0.1 0.0 0.0 0.1 -0.1 -1.0
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 4.0 1.0 0.9 0.0 0.0 1.4 -0.9 2.0
Blood clot in the leg (DVT) 3.2 4.2 8.9 -2.8 -2.4 0.0 0.0 -3.0 2.5 -0.5
Medication: Paracetamol 0.3 0.4 1.6 -0.5 0.4 0.0 0.0 -0.8 0.6 -1.3
Headache pain in last month 0.1 0.1 0.5 -0.7 0.1 0.0 0.0 0.2 -0.5 -0.1
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 2.4 0.3 -1.6 0.0 0.0 -0.6 0.9 -0.4
Glaucoma (self-reported) 1.1 1.3 4.8 1.9 0.1 0.0 0.0 0.2 -2.2 0.7
Gout (self-reported) 0.7 1.0 5.8 -0.8 -0.2 0.0 0.0 0.1 2.4 -0.6
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 4.4 -2.1 0.7 0.0 0.0 -0.5 -0.2 0.4
Medication: Amlodipine 0.2 0.3 1.1 -0.3 0.4 0.0 0.0 -1.1 -0.7 -0.3
Medication: Ventolin 100micrograms inhaler 1.0 1.3 5.0 1.7 2.2 0.0 0.0 0.9 -0.4 -0.1
Birth weight 0.8 1.8 5.5 2.4 2.2 0.0 0.0 1.3 -0.3 -0.2
Chronic bronchitis/emphysema (mother) 1.6 1.9 5.4 -2.1 0.4 0.0 0.0 -1.0 2.3 1.5
High blood pressure (siblings) 0.9 1.3 3.2 -0.2 1.8 0.0 0.0 0.4 -1.7 -1.8
Forced vital capacity (FVC), Best measure 0.4 1.5 6.0 1.7 1.1 0.0 0.0 2.4 -0.4 0.8
Body fat percentage 0.7 2.8 9.1 -2.8 -1.0 0.0 0.0 -3.0 1.3 -0.6
Leg fat percentage (right) 0.8 3.0 9.6 -2.3 -1.8 0.0 0.0 -3.1 1.2 -1.3
Arm fat-free mass (right) 0.4 1.9 9.1 1.9 0.4 0.0 0.0 0.1 -3.0 -0.8
Exposure to tobacco smoke outside home 1.1 1.4 4.8 -0.3 -0.4 0.0 0.0 -2.2 0.4 2.2
Comparative body size at age 10 1.1 3.0 9.8 -2.6 -1.3 0.0 0.0 -3.1 1.5 -0.9
Number of full brothers 0.9 1.1 3.1 -1.8 -0.6 0.0 0.0 -1.7 0.9 -0.6
Worry too long after embarrassment 0.3 0.5 1.1 0.9 -0.7 0.0 0.0 0.2 -1.0 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 3.1 0.6 -1.8 0.0 0.0 0.1 0.3 0.4
Wheeze or whistling in the chest in last year 0.6 1.2 2.9 -1.7 -0.5 0.0 0.0 -1.3 1.6 -0.7
Number of children fathered 0.6 0.7 2.8 1.7 1.1 0.0 0.0 0.2 -0.9 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.8 0.5 0.8 0.0 0.0 1.3 1.2 1.2
Age at first live birth 0.2 0.3 1.3 0.4 0.6 0.0 0.0 -0.1 1.1 0.1
Pulse wave peak to peak time 0.8 1.0 3.7 1.9 -0.5 0.0 0.0 1.3 -0.8 -0.7
Health satisfaction 0.6 0.7 2.4 -0.9 0.4 0.0 0.0 -1.6 -1.3 -0.1
Shortness of breath walking on level ground 2.5 3.0 8.9 -1.6 -1.5 0.0 0.0 -3.0 2.8 -0.2
Qualifications: College or University degree 0.5 1.7 7.5 0.2 0.3 0.0 0.0 0.9 -2.7 -1.9
Eye problems/disorders: None of the above 0.5 0.6 1.9 -1.4 -0.6 0.0 0.0 -0.7 0.9 0.8
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.9 -0.1 -0.8 0.0 0.0 -1.7 -0.6 -0.4
Emphysema/chronic bronchitis 0.2 0.3 0.8 -0.7 0.7 0.0 0.0 -0.4 0.2 0.9
Medication for pain relief, constipation, heartburn 0.9 1.5 5.2 1.2 0.3 0.0 0.0 2.3 -0.1 2.0
Neck or shoulder pain in last month 0.1 0.1 0.4 -0.6 -0.2 0.0 0.0 0.1 0.1 -0.6
Medication: Blood pressure 0.4 0.7 3.1 0.1 1.8 0.0 0.0 0.1 -1.2 -0.2
Angina (self-reported) 1.4 1.8 4.1 -1.1 -1.4 0.0 0.0 -1.5 2.0 -1.8
Migraine (self-reported) 0.9 1.1 3.9 2.0 0.7 0.0 0.0 1.6 -0.4 -0.8
Medication: Ibuprofen 1.0 1.2 3.3 -0.7 -1.7 0.0 0.0 -1.8 -0.5 -1.2
Medication: Allopurinol 0.7 0.9 3.0 -1.0 -0.4 0.0 0.0 -0.6 1.7 -1.3
Medication: Omeprazole 1.0 1.2 3.8 -1.9 1.4 0.0 0.0 -1.6 -0.4 -0.0
Medication: Seretide 50 evohaler 0.9 1.1 5.3 0.4 1.4 0.0 0.0 0.1 2.3 -0.5
Mean time to correctly identify matches 0.9 1.7 7.3 -1.8 -1.0 0.0 0.0 -2.7 -0.7 0.1
Heart disease (mother) 0.4 0.4 2.8 0.1 0.4 0.0 0.0 0.3 1.7 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 7.6 0.2 2.2 0.0 0.0 1.2 1.3 2.8
Whole body fat mass 0.3 1.1 4.8 -1.4 -0.5 0.0 0.0 -2.2 0.1 -0.7
Leg fat mass (right) 0.5 1.9 7.4 -1.4 -1.5 0.0 0.0 -2.7 0.3 -1.3
Arm predicted mass (right) 0.3 1.7 8.1 1.7 0.0 0.0 0.0 -0.1 -2.8 -1.0
Pulse rate, automated reading 0.4 1.4 4.8 -0.9 2.0 0.0 0.0 0.5 -0.2 2.2
Alcohol intake frequency. 0.2 0.6 3.2 0.1 1.8 0.0 0.0 0.1 0.0 0.9
Comparative height size at age 10 1.4 7.8 26.6 1.6 3.3 0.0 0.0 5.2 -3.8 -0.2
Number of full sisters 1.4 1.7 5.6 -2.4 -0.9 0.0 0.0 -1.5 1.2 -1.3
Suffer from ‘nerves’ 0.5 0.8 4.6 0.7 -2.1 0.0 0.0 0.2 -0.6 0.1
Overall health rating 0.6 1.2 3.8 -2.0 -0.5 0.0 0.0 -1.7 -1.2 -0.5
Chest pain or discomfort 2.9 4.2 12.0 -1.7 -1.9 0.0 0.0 -3.5 0.9 -3.2
Had major operations 0.2 0.3 1.4 -0.0 -0.4 0.0 0.0 0.4 0.2 -1.2
Age at last live birth 0.0 0.1 0.2 0.0 0.1 0.0 0.0 -0.3 0.5 -0.2
Family relationship satisfaction 0.7 0.8 5.2 0.5 -0.3 0.0 0.0 0.2 -0.0 -2.3
Leg pain on walking 1.2 1.4 4.8 -2.0 -0.9 0.0 0.0 -2.2 0.1 -0.8
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 7.1 -1.0 0.2 0.0 0.0 -0.2 2.7 1.6
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.4 -0.1 1.1 0.0 0.0 -1.2 1.2 0.0
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 7.2 1.5 -0.9 0.0 0.0 2.7 -0.9 -0.4
Medication: Aspirin 0.7 1.0 2.8 -1.7 -0.3 0.0 0.0 -0.7 1.2 -1.4
Supplements: Vitamin C 0.9 1.1 4.3 -2.1 0.9 0.0 0.0 -1.4 0.7 0.3
Knee pain experienced in last month 0.5 0.7 2.7 -0.5 0.6 0.0 0.0 -0.3 1.3 1.6
Hypertension (Self-reported) 0.6 1.8 5.7 -1.0 2.4 0.0 0.0 0.3 -2.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 7.2 -2.7 1.2 0.0 0.0 -1.0 -0.8 -0.4
Illnesses of father: Heart disease 0.5 0.7 3.7 -0.8 1.9 0.0 0.0 -0.8 0.1 -0.4
Illnesses of siblings: Diabetes 0.2 0.2 0.6 -0.3 0.6 0.0 0.0 0.6 0.6 0.8
Smoking status: Previous 3.2 4.7 15.8 0.8 4.0 0.0 0.0 3.4 0.6 2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.1 0.8 1.4 0.0 0.0 1.7 -0.9 -0.1
Whole body fat-free mass 0.5 2.7 11.0 2.3 -0.4 0.0 0.0 0.3 -3.3 -1.6
Leg fat-free mass (right) 0.3 1.6 6.4 1.8 -0.0 0.0 0.0 0.1 -2.5 -1.3
Arm fat percentage (left) 0.9 3.6 12.5 -2.7 -1.5 0.0 0.0 -3.5 1.2 -1.4
Average weekly red wine intake 1.9 2.8 6.3 2.1 1.6 0.0 0.0 2.3 -2.5 -1.0
Handedness (chirality/laterality): Left-handed 0.5 0.7 3.5 0.7 -0.6 0.0 0.0 -0.3 0.4 -1.9
Mood swings 0.7 1.3 7.6 0.4 0.9 0.0 0.0 0.4 -2.8 -0.2
Loneliness, isolation 0.4 0.6 1.6 -1.1 -0.8 0.0 0.0 -0.8 -1.3 0.1
Long-standing illness, disability or infirmity 0.3 0.5 1.6 -1.0 -0.6 0.0 0.0 -0.6 -0.2 -1.3
Ever had bowel cancer screening 0.8 0.9 4.3 -0.6 -0.9 0.0 0.0 -0.4 2.1 -0.9
Diabetes diagnosed by doctor 0.4 0.6 2.8 -1.7 0.9 0.0 0.0 0.0 0.7 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 2.4 -0.4 -1.5 0.0 0.0 -0.6 0.2 -0.1
Friendships satisfaction 0.9 1.2 3.1 0.5 -1.7 0.0 0.0 0.7 -1.4 -1.5
Qualifications: nursing, teaching 0.5 0.7 3.5 0.1 -1.2 0.0 0.0 0.1 -0.0 -1.9
Commuting to job workplace: Walk 0.6 0.6 2.5 0.5 -0.4 0.0 0.0 1.1 -1.6 0.6
Eye problems/disorders: Cataract 0.5 0.6 2.8 -0.2 1.0 0.0 0.0 -0.4 -0.6 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.3 0.6 -0.3 0.0 0.0 0.8 -2.1 1.6
Medication for cholesterol 0.6 0.9 3.2 0.6 -1.8 0.0 0.0 -0.1 -1.1 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 1.0 -0.1 -0.7 0.0 0.0 -1.0 -0.6 -0.1
Back pain experienced in last month 0.8 1.2 4.2 -0.6 0.0 0.0 0.0 -1.6 1.0 2.1
Mineral and other dietary supplements 0.9 1.2 2.2 1.5 1.5 0.0 0.0 1.2 -1.4 -0.8
Breast cancer (self-reported) 2.4 2.8 13.4 1.2 3.7 0.0 0.0 1.1 -0.0 1.9
Asthma (self-reported) 0.7 1.5 7.0 0.0 2.7 0.0 0.0 1.3 -1.1 -0.6
Osteoporosis (self-reported) 0.3 0.4 1.9 -0.1 0.2 0.0 0.0 0.8 0.3 1.4
Osteoarthritis (self-reported) 0.2 0.3 1.5 -0.3 -0.0 0.0 0.0 -0.6 -1.2 0.3
Medication: Aspirin 0.8 1.0 4.0 -1.5 -0.4 0.0 0.0 -0.6 0.5 -2.0
Medication: Gliclazide 0.2 0.3 1.7 -1.3 0.3 0.0 0.0 0.1 -0.3 0.1
Illnesses of father: None of the above (group 1) 1.3 1.6 8.3 0.8 -2.9 0.0 0.0 -1.5 0.5 -0.2
Smoking status: Current 0.6 1.0 3.1 -0.8 -1.1 0.0 0.0 -1.2 1.7 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.2 1.1 0.9 0.0 0.0 0.9 0.2 0.5
Whole body water mass 0.5 3.0 11.9 2.4 -0.3 0.0 0.0 0.5 -3.4 -1.7
Leg predicted mass (right) 0.3 1.6 6.5 1.7 -0.0 0.0 0.0 0.0 -2.6 -1.3
Arm fat mass (left) 0.4 1.8 7.0 -1.3 -1.4 0.0 0.0 -2.6 0.0 -1.3
Number of self-reported non-cancer illnesses 0.2 0.3 1.3 -0.9 0.6 0.0 0.0 -0.0 -1.1 -0.1
Average weekly champagne plus white wine intake 0.1 0.2 0.7 -0.8 0.2 0.0 0.0 0.3 -0.1 0.6
Miserableness 0.1 0.2 1.2 0.2 0.2 0.0 0.0 -0.5 -1.1 -0.3
Guilty feelings 0.2 0.3 1.5 0.6 0.3 0.0 0.0 -0.1 -0.5 1.2
Wears glasses or contact lenses 0.5 0.6 1.5 1.1 0.7 0.0 0.0 1.0 -1.2 0.1
Ever taken oral contraceptive pill 0.7 0.8 2.8 0.8 1.7 0.0 0.0 0.7 0.1 1.2
Hearing aid user 0.3 0.3 1.4 -0.0 -0.7 0.0 0.0 0.6 -0.1 -1.2
Mother’s age at death 0.4 0.6 1.3 -1.1 -0.2 0.0 0.0 -0.2 1.1 1.1
Financial situation satisfaction 1.7 2.1 7.0 0.1 -1.6 0.0 0.0 -1.5 -2.6 -1.6
Tinnitus: Yes, now most or all of the time 1.2 1.4 5.3 -0.2 1.8 0.0 0.0 -0.0 2.3 0.9
Commuting to job workplace: Public transport 0.3 0.4 1.0 -0.9 0.2 0.0 0.0 -1.0 -0.8 -0.1
Eye problems/disorders: Glaucoma 1.2 1.5 6.7 2.6 0.5 0.0 0.0 0.5 -1.7 0.5
Medication: Blood pressure 0.2 0.4 1.5 -1.2 0.6 0.0 0.0 -0.0 -0.0 -1.1
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.3 -0.4 -1.1 0.0 0.0 -0.6 0.5 -0.3
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.7 -1.2 -1.3 0.0 0.0 -1.6 1.6 1.1
High cholesterol (Self-reported) 1.2 2.1 8.6 1.4 1.6 0.0 0.0 0.7 0.8 2.9
Medication: Bendroflumethiazide 0.6 0.9 3.2 -0.3 1.8 0.0 0.0 1.4 1.0 -0.1
Medication: Paracetamol 0.4 0.6 1.4 -0.5 0.9 0.0 0.0 -0.0 1.2 -1.2
Medication: Lisinopril 2.1 2.7 8.5 1.0 2.9 0.0 0.0 1.9 -2.1 1.2
Medication: Atorvastatin 0.4 0.5 1.6 0.2 1.3 0.0 0.0 0.7 0.5 0.9
Illnesses of father: High blood pressure 1.1 1.3 3.6 0.3 1.5 0.0 0.0 1.9 -1.8 -0.1
Alcohol drinker status: Never 0.5 0.6 2.0 0.6 0.5 0.0 0.0 1.2 -0.0 -1.4
Ever smoked 0.6 1.0 3.2 -0.3 1.2 0.0 0.0 1.5 0.6 1.8
Basal metabolic rate 0.4 2.2 8.6 1.8 -0.6 0.0 0.0 -0.1 -2.9 -1.8
Leg fat percentage (left) 0.8 3.0 9.6 -2.5 -1.4 0.0 0.0 -3.1 1.1 -1.4
Arm fat-free mass (left) 0.5 2.5 11.0 1.5 -0.6 0.0 0.0 -0.4 -3.3 -1.9
Number of operations (self-reported) 0.0 0.1 0.2 0.4 0.3 0.0 0.0 -0.4 0.0 -0.0
Average weekly beer plus cider intake 1.3 1.9 9.8 1.1 0.4 0.0 0.0 -0.4 3.1 1.5
Irritability 1.1 1.9 6.4 0.6 0.8 0.0 0.0 2.5 -2.2 -0.8
Risk taking 0.3 0.5 1.2 -0.1 -1.1 0.0 0.0 -0.8 1.1 0.4
Ever had prostate specific antigen (PSA) test 1.0 1.1 6.9 -0.1 0.3 0.0 0.0 -0.3 2.6 -0.8
Fractured/broken bones in last 5 years 1.8 2.3 7.9 -0.8 -2.3 0.0 0.0 -2.8 -1.4 -0.5
Age started oral contraceptive pill 0.1 0.1 0.4 0.6 0.4 0.0 0.0 -0.0 0.1 -0.6
Diastolic blood pressure, automated reading 0.3 1.0 2.6 0.3 1.5 0.0 0.0 -1.3 -1.6 0.1
Ever depressed for a whole week 1.6 2.0 4.8 -1.9 -1.7 0.0 0.0 -1.5 0.5 -2.2
Unable to work because of sickness or disability 0.2 0.3 1.0 -0.1 0.0 0.0 0.0 -0.5 1.0 -0.9
Commuting to job workplace: Cycle 1.2 1.4 4.7 -1.0 -2.2 0.0 0.0 -0.4 -1.1 -1.7
Myopia 0.3 0.5 1.5 0.8 0.9 0.0 0.0 0.2 1.2 -0.6
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.4 1.0 -2.1 0.0 0.0 -0.3 1.9 0.2
Cholesterol lowering medication 1.0 1.5 5.6 -0.7 1.7 0.0 0.0 -0.6 2.4 1.2
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 2.9 -1.7 1.6 0.0 0.0 -1.1 -0.1 1.3
Pain experienced in last month 0.1 0.1 0.6 -0.2 -0.2 0.0 0.0 -0.1 -0.5 -0.8
Supplements: Calcium 0.6 0.6 2.2 -1.5 0.7 0.0 0.0 1.0 0.3 -0.6
Basal cell carcinoma (self-reported) 0.2 0.3 1.8 0.2 0.3 0.0 0.0 -1.3 0.2 0.3
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.9 -0.2 -0.9 0.0 0.0 -0.4 0.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 3.0 3.8 8.6 -2.7 -2.3 0.0 0.0 -2.9 2.4 -0.2
Heart disease (siblings) 0.1 0.1 0.6 0.1 -0.3 0.0 0.0 -0.3 -0.8 0.0
Alcohol drinker status: Previous 0.4 0.4 1.2 -0.4 1.1 0.0 0.0 -0.6 1.0 -0.3
Pack years of smoking 0.5 0.7 1.3 -1.1 -1.1 0.0 0.0 -0.9 0.7 1.1
Impedance of whole body 0.4 1.9 5.2 -2.3 1.5 0.0 0.0 1.6 0.6 1.7
Leg fat mass (left) 0.4 1.7 6.7 -1.6 -1.2 0.0 0.0 -2.6 0.2 -1.3
Arm predicted mass (left) 0.5 2.5 10.2 1.9 -0.7 0.0 0.0 -0.5 -3.2 -1.8