TWAS hub - ZNF850

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.044	0.0210	0.00083	0.011	0.018	0.005	NA	0.004	0.0160	0.0025	0.0750	NA	0.10000
2	GTEx	Breast Mammary Tissue	0.216	0.1080	0.00450	0.028	NA	0.020	NA	-0.001	0.0140	NA	0.0310	NA	0.35000
3	GTEx	Breast Mammary Tissue (Male)	0.153	0.0994	0.05400	-0.012	NA	-0.009	NA	-0.013	0.7400	NA	0.5800	NA	0.86000
4	GTEx	Breast Mammary Tissue (Female)	0.165	0.1089	0.03800	-0.010	NA	0.036	NA	-0.009	0.8600	NA	0.0300	NA	0.76000
5	GTEx	Heart Atrial Appendage	0.080	0.0350	0.00160	0.026	NA	0.056	NA	0.029	0.0250	NA	0.0016	NA	0.01800
6	GTEx	Skin Not Sun Exposed Suprapubic	0.101	0.0570	0.00850	-0.001	NA	0.003	NA	-0.005	0.3500	NA	0.2000	NA	0.84000
7	GTEx	Spleen	0.336	0.1210	0.00100	0.099	NA	0.104	NA	0.142	0.0016	NA	0.0013	NA	0.00017

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	5	6	7
Primary Biliary Cirrhosis	3.8	5.5	11.0	3.2	2.8	3.3	-1.1	2.8
Multivitamins +/- minerals	3.3	4.2	11.1	-2.9	-1.5	-3.3	2.9	-0.1
Blood clot in the leg (DVT)	3.2	4.2	8.9	-2.8	-2.4	-3.0	2.5	-0.5
Smoking status: Previous	3.2	4.7	15.8	0.8	4.0	3.4	0.6	2.2
Deep venous thrombosis (DVT) (self-reported)	3.0	3.8	8.6	-2.7	-2.3	-2.9	2.4	-0.2
Chest pain or discomfort	2.9	4.2	12.0	-1.7	-1.9	-3.5	0.9	-3.2
Crohns Disease (2017)	2.7	5.9	24.4	1.5	4.9	3.8	-0.5	-0.2
Vitamin and mineral supplements	2.7	3.6	12.4	3.5	1.1	2.6	-2.2	0.4
Tinnitus: Yes, but not now, but have in the past	2.6	2.7	5.1	-1.8	-2.2	-2.2	-1.2	-2.1
Pulse wave reflection index	2.6	3.2	7.6	-2.4	-1.5	-2.6	2.7	0.3
Shortness of breath walking on level ground	2.5	3.0	8.9	-1.6	-1.5	-3.0	2.8	-0.2
Crohns Disease (2012)	2.4	3.8	17.9	1.9	4.2	2.2	-0.6	-0.6
Hand grip strength (left)	2.4	6.2	22.9	3.4	2.6	4.8	-1.0	-1.0
Breast cancer (self-reported)	2.4	2.8	13.4	1.2	3.7	1.1	-0.0	1.9
Intelligence (Savage-Jansen 2018)	2.2	6.8	33.9	-1.4	-2.6	-2.2	-0.1	-5.8
Hand grip strength (right)	2.2	6.1	19.7	4.4	1.9	4.2	-0.9	-0.8
Medication: Lisinopril	2.1	2.7	8.5	1.0	2.9	1.9	-2.1	1.2
Lung FEV1/FVC ratio	2.0	10.0	34.6	-0.5	-4.4	-5.9	-1.0	-3.9
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	7.2	-0.6	-2.7	-1.8	-0.2	-2.5
Falls in the last year	2.0	2.8	8.0	-1.1	-2.8	-2.7	1.2	-1.1
Verbal and Numeric Reasoning (VNR)	1.9	4.6	19.8	-1.0	-2.6	-2.1	0.4	-4.5
Lung cancer (father)	1.9	2.2	6.4	-0.1	-2.5	-2.1	-0.2	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	7.6	0.2	2.2	1.2	1.3	2.8
Average weekly red wine intake	1.9	2.8	6.3	2.1	1.6	2.3	-2.5	-1.0
Reaction Time	1.8	3.3	13.0	-2.5	-2.0	-3.6	-0.7	-0.1
HbA1C	1.8	2.0	6.4	1.5	2.5	1.4	-0.2	1.8
Fractured/broken bones in last 5 years	1.8	2.3	7.9	-0.8	-2.3	-2.8	-1.4	-0.5
Ovarian Cancer	1.7	2.2	8.7	0.1	1.5	2.1	0.2	2.9
Financial situation satisfaction	1.7	2.1	7.0	0.1	-1.6	-1.5	-2.6	-1.6
Fluid intelligence score	1.6	3.3	13.0	-1.2	-2.5	-1.5	-0.4	-3.6
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	6.7	-1.9	-1.9	-2.6	-1.7	-1.0
Chronic bronchitis/emphysema (mother)	1.6	1.9	5.4	-2.1	0.4	-1.0	2.3	1.5
Ever depressed for a whole week	1.6	2.0	4.8	-1.9	-1.7	-1.5	0.5	-2.2
Bipolar Disorder (2011)	1.5	1.4	4.7	0.5	-1.2	-1.8	2.2	-0.6
Height	1.5	28.3	71.9	7.2	3.9	8.5	-7.7	-0.9
Past tobacco smoking	1.5	2.7	7.3	-0.1	-2.7	-2.4	-0.7	-2.4
Angina (self-reported)	1.4	1.8	4.1	-1.1	-1.4	-1.5	2.0	-1.8
Comparative height size at age 10	1.4	7.8	26.6	1.6	3.3	5.2	-3.8	-0.2
Number of full sisters	1.4	1.7	5.6	-2.4	-0.9	-1.5	1.2	-1.3
Blood Eosinophil Count	1.3	9.9	29.4	4.0	3.1	5.4	-3.8	0.4
Severe depression (siblings)	1.3	1.5	3.5	-1.9	-1.5	-0.7	-1.2	-1.7
Maternal smoking around birth	1.3	1.9	4.9	-1.9	-1.6	-2.2	0.5	-1.4
Qualifications: CSEs or equivalent	1.3	1.7	7.1	-1.0	0.1	-2.7	1.1	1.5
High blood pressure (mother)	1.3	1.8	8.1	-0.4	0.4	0.1	-2.9	-1.9
Happiness	1.3	1.6	6.5	0.6	0.1	1.4	-2.5	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	7.1	-1.0	0.2	-0.2	2.7	1.6
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	7.2	1.5	-0.9	2.7	-0.9	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	7.2	-2.7	1.2	-1.0	-0.8	-0.4
Illnesses of father: None of the above (group 1)	1.3	1.6	8.3	0.8	-2.9	-1.5	0.5	-0.2
Average weekly beer plus cider intake	1.3	1.9	9.8	1.1	0.4	-0.4	3.1	1.5
Chronotype (morning person)	1.2	2.9	6.5	1.7	2.3	2.2	0.7	2.6
Angina	1.2	1.6	3.4	-0.9	-1.3	-1.3	1.8	-1.8
Leg pain on walking	1.2	1.4	4.8	-2.0	-0.9	-2.2	0.1	-0.8
Tinnitus: Yes, now most or all of the time	1.2	1.4	5.3	-0.2	1.8	-0.0	2.3	0.9
Eye problems/disorders: Glaucoma	1.2	1.5	6.7	2.6	0.5	0.5	-1.7	0.5
High cholesterol (Self-reported)	1.2	2.1	8.6	1.4	1.6	0.7	0.8	2.9
Commuting to job workplace: Cycle	1.2	1.4	4.7	-1.0	-2.2	-0.4	-1.1	-1.7
Irritable Bowel Disease (IBD)	1.1	2.6	7.3	0.7	2.7	2.4	-1.9	-0.8
Hearing difficulty/problems: Yes	1.1	1.7	4.7	-1.5	-0.3	-2.1	2.2	0.7
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	6.2	-0.7	-0.9	-0.4	-2.5	-1.0
Sitting height	1.1	7.9	27.4	1.7	1.6	5.2	-4.6	-1.3
Time employed in main current job	1.1	1.3	5.6	-1.0	2.4	0.3	1.4	0.6
Glaucoma (self-reported)	1.1	1.3	4.8	1.9	0.1	0.2	-2.2	0.7
Exposure to tobacco smoke outside home	1.1	1.4	4.8	-0.3	-0.4	-2.2	0.4	2.2
Comparative body size at age 10	1.1	3.0	9.8	-2.6	-1.3	-3.1	1.5	-0.9
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.7	-1.2	-1.3	-1.6	1.6	1.1
Illnesses of father: High blood pressure	1.1	1.3	3.6	0.3	1.5	1.9	-1.8	-0.1
Irritability	1.1	1.9	6.4	0.6	0.8	2.5	-2.2	-0.8
Rheumatoid Arthritis	1.0	1.4	4.8	-1.2	1.3	-2.2	1.4	0.3
Frequency of depressed mood in last 2 weeks	1.0	1.5	3.8	-1.9	-1.2	-0.8	-1.6	-1.3
Fed-up feelings	1.0	1.8	5.6	-1.4	-0.7	-0.9	-1.9	-2.4
Had menopause	1.0	1.2	7.5	-0.2	0.5	0.6	-2.7	-0.7
Number of live births	1.0	1.5	5.5	-1.1	-1.3	-2.3	-1.4	-0.2
Length of working week for main job	1.0	1.1	4.0	-1.3	-0.2	-2.0	1.1	-0.6
Medication: Ventolin 100micrograms inhaler	1.0	1.3	5.0	1.7	2.2	0.9	-0.4	-0.1
Medication: Ibuprofen	1.0	1.2	3.3	-0.7	-1.7	-1.8	-0.5	-1.2
Medication: Omeprazole	1.0	1.2	3.8	-1.9	1.4	-1.6	-0.4	-0.0
Ever had prostate specific antigen (PSA) test	1.0	1.1	6.9	-0.1	0.3	-0.3	2.6	-0.8
Cholesterol lowering medication	1.0	1.5	5.6	-0.7	1.7	-0.6	2.4	1.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.9	-1.7	1.6	-1.1	-0.1	1.3
Respiratory disease	0.9	1.9	9.7	-0.5	3.1	1.7	-0.6	-0.2
Medication: Metformin	0.9	1.3	4.4	-1.6	1.2	0.1	0.7	2.1
Number of incorrect matches in round	0.9	1.4	6.6	-1.3	0.9	2.6	-0.5	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.8	-1.4	-1.1	-1.4	-1.9	-0.7
Hair/balding pattern: Pattern 2	0.9	1.1	5.6	-0.2	-1.2	-0.9	-2.4	-0.5
Arm fat percentage (right)	0.9	3.6	12.3	-2.4	-1.9	-3.5	1.1	-1.5
Hair/balding pattern: Pattern 3	0.9	1.3	3.7	-1.3	-0.5	-1.7	1.9	-0.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	4.0	1.0	0.9	1.4	-0.9	2.0
High blood pressure (siblings)	0.9	1.3	3.2	-0.2	1.8	0.4	-1.7	-1.8
Number of full brothers	0.9	1.1	3.1	-1.8	-0.6	-1.7	0.9	-0.6
Medication for pain relief, constipation, heartburn	0.9	1.5	5.2	1.2	0.3	2.3	-0.1	2.0
Migraine (self-reported)	0.9	1.1	3.9	2.0	0.7	1.6	-0.4	-0.8
Medication: Seretide 50 evohaler	0.9	1.1	5.3	0.4	1.4	0.1	2.3	-0.5
Mean time to correctly identify matches	0.9	1.7	7.3	-1.8	-1.0	-2.7	-0.7	0.1
Supplements: Vitamin C	0.9	1.1	4.3	-2.1	0.9	-1.4	0.7	0.3
Arm fat percentage (left)	0.9	3.6	12.5	-2.7	-1.5	-3.5	1.2	-1.4
Friendships satisfaction	0.9	1.2	3.1	0.5	-1.7	0.7	-1.4	-1.5
Mineral and other dietary supplements	0.9	1.2	2.2	1.5	1.5	1.2	-1.4	-0.8
Prostate Cancer	0.8	1.1	4.6	1.6	-0.7	0.5	0.5	2.1
Coronary Artery Disease (CAD)	0.8	1.0	3.3	-0.7	-0.1	-1.8	-1.7	-0.7
Type 2 Diabetes (T2D) (2012)	0.8	0.9	3.7	1.1	-0.4	0.8	-1.9	-0.8
Waist Hip Ratio (WHR)	0.8	3.5	10.0	-2.3	0.9	-1.7	2.3	3.2
Systolic Blood Pressure	0.8	4.2	12.0	1.3	3.5	2.2	-3.2	-0.5
Number of treatments/medications taken	0.8	1.5	6.9	-2.6	1.9	-0.1	-0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.4	-1.3	-1.6	-0.9	-0.8	-1.3
Age when periods started (menarche)	0.8	1.9	3.5	-0.8	1.9	-1.9	1.6	1.8
Alcohol usually taken with meals	0.8	1.3	6.4	0.2	-0.0	1.6	-2.5	-0.7
Financial difficulties in last 2 years	0.8	1.1	5.7	-0.9	0.1	-2.4	-0.9	-0.3
Medication: Ramipril	0.8	1.0	3.1	-1.8	0.1	-1.5	-0.3	-1.4
Noisy workplace	0.8	0.9	3.5	-1.3	0.9	-0.8	1.9	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.5	-0.6	-1.6	-1.1	-0.9	-1.5
Standing height	0.8	8.3	22.8	2.8	2.2	4.8	-4.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	5.8	0.7	-2.4	-0.5	0.2	-1.3
Birth weight of first child	0.8	1.4	4.5	2.1	0.7	1.2	-0.1	-1.9
Birth weight	0.8	1.8	5.5	2.4	2.2	1.3	-0.3	-0.2
Leg fat percentage (right)	0.8	3.0	9.6	-2.3	-1.8	-3.1	1.2	-1.3
Pulse wave peak to peak time	0.8	1.0	3.7	1.9	-0.5	1.3	-0.8	-0.7
Ever had bowel cancer screening	0.8	0.9	4.3	-0.6	-0.9	-0.4	2.1	-0.9
Back pain experienced in last month	0.8	1.2	4.2	-0.6	0.0	-1.6	1.0	2.1
Medication: Aspirin	0.8	1.0	4.0	-1.5	-0.4	-0.6	0.5	-2.0
Leg fat percentage (left)	0.8	3.0	9.6	-2.5	-1.4	-3.1	1.1	-1.4
Major Depression (MDD)	0.7	0.9	4.4	-2.1	-1.1	-0.5	-0.3	-0.3
Breast Cancer	0.7	1.7	6.9	-2.6	-0.8	-1.9	0.8	-0.2
Lupus	0.7	1.1	5.3	-0.4	-0.5	-0.6	-2.3	-1.2
Allergy or Eczema	0.7	1.9	5.6	0.8	1.6	2.4	-0.1	2.2
Supplements: Zinc	0.7	0.8	3.2	-1.4	-0.3	0.4	-0.2	-1.8
Townsend deprivation index at recruitment	0.7	1.0	4.8	1.0	-0.4	2.2	0.9	-0.5
Current tobacco smoking	0.7	1.2	3.9	-0.8	-1.0	-1.4	2.0	0.8
Relative age voice broke	0.7	1.1	4.1	-1.2	-0.0	-1.3	2.0	0.6
Hayfever, allergic rhinitis or eczema	0.7	1.6	5.6	1.2	1.3	2.4	-0.4	1.5
Supplements: Glucosamine	0.7	0.9	3.4	-1.8	-1.1	-1.1	0.5	-0.3
Medication: Levothyroxine sodium	0.7	1.2	4.2	-2.1	1.5	-1.1	-0.4	0.7
Trunk fat-free mass	0.7	3.9	15.1	2.7	-0.4	0.9	-3.9	-1.9
Father’s age at death	0.7	0.9	3.0	1.7	-0.8	1.4	-0.8	0.3
Illnesses of mother	0.7	0.9	2.7	-0.1	-1.4	-1.1	1.6	-0.7
Trunk predicted mass	0.7	4.0	15.1	2.7	-0.4	0.9	-3.9	-2.1
Gout (self-reported)	0.7	1.0	5.8	-0.8	-0.2	0.1	2.4	-0.6
Body fat percentage	0.7	2.8	9.1	-2.8	-1.0	-3.0	1.3	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	0.5	0.8	1.3	1.2	1.2
Medication: Allopurinol	0.7	0.9	3.0	-1.0	-0.4	-0.6	1.7	-1.3
Family relationship satisfaction	0.7	0.8	5.2	0.5	-0.3	0.2	-0.0	-2.3
Medication: Aspirin	0.7	1.0	2.8	-1.7	-0.3	-0.7	1.2	-1.4
Mood swings	0.7	1.3	7.6	0.4	0.9	0.4	-2.8	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.3	0.6	-0.3	0.8	-2.1	1.6
Asthma (self-reported)	0.7	1.5	7.0	0.0	2.7	1.3	-1.1	-0.6
Ever taken oral contraceptive pill	0.7	0.8	2.8	0.8	1.7	0.7	0.1	1.2
Alzheimer’s Disease (in mother)	0.6	0.7	2.6	1.2	-0.1	1.0	-0.2	-1.6
Blood Platelet Count	0.6	6.8	29.1	1.2	-3.5	-5.4	0.7	-2.0
Smoking Status	0.6	1.4	3.4	0.6	1.8	1.3	1.2	1.7
Hypothyroidism (self reported)	0.6	1.4	8.9	-3.0	0.7	0.3	-0.0	0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.9	-2.0	1.4	0.1	0.5	1.3
Sensitivity / hurt feelings	0.6	1.1	4.4	-1.0	-2.1	-1.5	-0.0	-0.0
Trunk fat percentage	0.6	2.4	7.9	-2.8	-0.6	-2.6	1.2	-0.5
Average weekly fortified wine intake	0.6	0.7	4.0	0.2	0.1	0.2	2.0	0.7
Taking other prescription medications	0.6	1.0	3.5	-1.9	1.0	-0.3	-1.4	0.4
Body mass index (BMI)	0.6	2.7	11.1	-1.1	-1.8	-3.3	0.7	-1.6
Waist circumference	0.6	2.3	8.8	-2.4	-1.0	-3.0	0.7	0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.8	-0.9	0.2	0.8	-2.0	-0.0
Medication: Simvastatin	0.6	0.9	2.4	-1.0	1.6	-0.6	1.2	1.1
Neuroticism score	0.6	1.3	7.5	0.7	-0.9	0.4	-2.7	-0.6
Asthma	0.6	1.2	6.0	-0.0	2.5	1.2	-1.0	-0.4
Medication: Lansoprazole	0.6	0.7	3.0	-1.7	0.1	-0.6	0.5	1.0
Tense / ‘highly strung’	0.6	0.9	4.2	0.8	-0.2	2.1	-1.2	0.4
Wheeze or whistling in the chest in last year	0.6	1.2	2.9	-1.7	-0.5	-1.3	1.6	-0.7
Number of children fathered	0.6	0.7	2.8	1.7	1.1	0.2	-0.9	0.3
Health satisfaction	0.6	0.7	2.4	-0.9	0.4	-1.6	-1.3	-0.1
Overall health rating	0.6	1.2	3.8	-2.0	-0.5	-1.7	-1.2	-0.5
Hypertension (Self-reported)	0.6	1.8	5.7	-1.0	2.4	0.3	-2.4	-0.4
Commuting to job workplace: Walk	0.6	0.6	2.5	0.5	-0.4	1.1	-1.6	0.6
Medication for cholesterol	0.6	0.9	3.2	0.6	-1.8	-0.1	-1.1	-1.1
Smoking status: Current	0.6	1.0	3.1	-0.8	-1.1	-1.2	1.7	0.8
Medication: Bendroflumethiazide	0.6	0.9	3.2	-0.3	1.8	1.4	1.0	-0.1
Ever smoked	0.6	1.0	3.2	-0.3	1.2	1.5	0.6	1.8
Supplements: Calcium	0.6	0.6	2.2	-1.5	0.7	1.0	0.3	-0.6
HDL Cholesterol	0.5	0.8	3.5	0.6	1.2	1.9	0.5	0.5
Ulcerative Colitis	0.5	0.7	4.8	0.0	0.2	0.0	-2.2	0.6
Lung FVC	0.5	2.4	13.0	-0.5	0.8	0.7	3.6	1.6
Neuroticism	0.5	1.2	6.5	0.8	-1.1	0.1	-2.5	-0.4
Average weekly spirits intake	0.5	0.6	3.0	-0.3	0.8	1.7	-0.2	-0.6
Systolic blood pressure, automated reading	0.5	1.4	5.6	0.5	2.4	0.9	-1.6	0.6
Diabetes (father)	0.5	0.6	2.9	-0.3	-0.0	0.9	-0.8	1.7
High blood pressure	0.5	1.4	4.4	-1.1	2.1	0.1	-2.1	-0.2
Stomach or abdominal pain in last month	0.5	0.6	3.5	-0.7	-0.3	0.2	-1.9	0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.8	-0.2	1.3	-0.1	1.2	1.0
Forced vital capacity (FVC)	0.5	2.0	5.0	2.2	1.6	2.2	-0.1	1.2
Mouth/teeth dental problems	0.5	0.7	3.6	-0.2	-1.2	-0.2	-0.1	-1.9
Pulse rate	0.5	0.9	2.5	-0.6	1.6	0.3	-1.4	1.2
Depression (self-reported)	0.5	0.6	3.1	-0.3	-1.8	0.3	0.3	0.7
Prospective memory result	0.5	0.6	2.7	-0.3	0.6	-0.7	1.6	0.8
Pulse wave Arterial Stiffness index	0.5	0.6	3.0	-1.7	0.8	-0.8	0.2	0.4
Arm fat mass (right)	0.5	2.2	8.2	-1.2	-1.7	-2.9	0.3	-1.7
Qualifications: College or University degree	0.5	1.7	7.5	0.2	0.3	0.9	-2.7	-1.9
Eye problems/disorders: None of the above	0.5	0.6	1.9	-1.4	-0.6	-0.7	0.9	0.8
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.9	-0.1	-0.8	-1.7	-0.6	-0.4
Leg fat mass (right)	0.5	1.9	7.4	-1.4	-1.5	-2.7	0.3	-1.3
Suffer from ‘nerves’	0.5	0.8	4.6	0.7	-2.1	0.2	-0.6	0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	-0.1	1.1	-1.2	1.2	0.0
Knee pain experienced in last month	0.5	0.7	2.7	-0.5	0.6	-0.3	1.3	1.6
Illnesses of father: Heart disease	0.5	0.7	3.7	-0.8	1.9	-0.8	0.1	-0.4
Whole body fat-free mass	0.5	2.7	11.0	2.3	-0.4	0.3	-3.3	-1.6
Handedness (chirality/laterality): Left-handed	0.5	0.7	3.5	0.7	-0.6	-0.3	0.4	-1.9
Qualifications: nursing, teaching	0.5	0.7	3.5	0.1	-1.2	0.1	-0.0	-1.9
Eye problems/disorders: Cataract	0.5	0.6	2.8	-0.2	1.0	-0.4	-0.6	-1.7
Whole body water mass	0.5	3.0	11.9	2.4	-0.3	0.5	-3.4	-1.7
Wears glasses or contact lenses	0.5	0.6	1.5	1.1	0.7	1.0	-1.2	0.1
Alcohol drinker status: Never	0.5	0.6	2.0	0.6	0.5	1.2	-0.0	-1.4
Arm fat-free mass (left)	0.5	2.5	11.0	1.5	-0.6	-0.4	-3.3	-1.9
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.4	1.0	-2.1	-0.3	1.9	0.2
Pack years of smoking	0.5	0.7	1.3	-1.1	-1.1	-0.9	0.7	1.1
Arm predicted mass (left)	0.5	2.5	10.2	1.9	-0.7	-0.5	-3.2	-1.8
Bipolar Disorder (2018)	0.4	0.6	1.8	1.3	-0.9	-0.3	0.7	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.6	2.4	0.7	0.6	0.4	-1.5	0.8
Worry (Nagel 2018)	0.4	0.8	3.0	0.8	-1.1	1.0	-1.7	0.0
Alzheimer’s Disease (including proxy)	0.4	0.6	3.6	0.6	-0.3	-0.1	0.3	-1.9
Ulcerative Colitis (UC)	0.4	0.7	4.6	0.2	-0.1	0.1	-2.1	-0.8
Mean Putamen Volume	0.4	0.5	1.8	0.2	-0.2	-1.3	-1.2	-0.4
Fasting Glucose	0.4	0.5	1.1	1.0	0.1	-0.9	-0.7	-1.0
Blood White Count	0.4	2.8	8.0	-0.5	-1.6	-2.8	2.3	-1.8
Heel T-Score	0.4	2.8	8.8	-0.8	-3.0	-0.6	-1.4	-2.8
BMI	0.4	2.4	11.1	-0.9	-1.7	-3.3	0.8	-1.3
Cardiovascular Disease	0.4	1.2	3.8	-1.1	2.0	0.1	-1.8	0.0
Relative age of first facial hair	0.4	0.9	2.9	-1.1	1.1	0.9	1.7	-0.5
Pack years adult smoking proportion	0.4	0.6	1.4	-0.7	-1.2	-1.1	0.8	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.7	0.8	-1.6	0.8	0.5	1.3
Nervous feelings	0.4	0.7	3.9	0.5	0.4	2.0	-0.9	0.2
Qualifications: None of the above	0.4	0.8	4.1	1.0	-0.2	0.6	0.3	2.0
Diabetes (self-reported)	0.4	0.6	1.9	-1.0	1.0	0.1	0.7	1.4
Illnesses of siblings	0.4	0.5	2.0	1.4	-0.5	0.4	0.9	0.5
Breastfed as a baby	0.4	0.5	1.8	1.3	-0.0	0.3	1.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	4.4	-2.1	0.7	-0.5	-0.2	0.4
Forced vital capacity (FVC), Best measure	0.4	1.5	6.0	1.7	1.1	2.4	-0.4	0.8
Arm fat-free mass (right)	0.4	1.9	9.1	1.9	0.4	0.1	-3.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	3.1	0.6	-1.8	0.1	0.3	0.4
Medication: Blood pressure	0.4	0.7	3.1	0.1	1.8	0.1	-1.2	-0.2
Heart disease (mother)	0.4	0.4	2.8	0.1	0.4	0.3	1.7	0.2
Pulse rate, automated reading	0.4	1.4	4.8	-0.9	2.0	0.5	-0.2	2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.1	0.8	1.4	1.7	-0.9	-0.1
Loneliness, isolation	0.4	0.6	1.6	-1.1	-0.8	-0.8	-1.3	0.1
Diabetes diagnosed by doctor	0.4	0.6	2.8	-1.7	0.9	0.0	0.7	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.4	-0.4	-1.5	-0.6	0.2	-0.1
Arm fat mass (left)	0.4	1.8	7.0	-1.3	-1.4	-2.6	0.0	-1.3
Mother’s age at death	0.4	0.6	1.3	-1.1	-0.2	-0.2	1.1	1.1
Medication: Paracetamol	0.4	0.6	1.4	-0.5	0.9	-0.0	1.2	-1.2
Medication: Atorvastatin	0.4	0.5	1.6	0.2	1.3	0.7	0.5	0.9
Basal metabolic rate	0.4	2.2	8.6	1.8	-0.6	-0.1	-2.9	-1.8
Alcohol drinker status: Previous	0.4	0.4	1.2	-0.4	1.1	-0.6	1.0	-0.3
Impedance of whole body	0.4	1.9	5.2	-2.3	1.5	1.6	0.6	1.7
Leg fat mass (left)	0.4	1.7	6.7	-1.6	-1.2	-2.6	0.2	-1.3
Bipolar Disorder or Schizophrenia	0.3	0.8	3.3	1.8	-1.3	-0.7	0.6	-0.0
Depressed Affect (Nagel 2018)	0.3	0.7	3.8	-0.1	0.1	-0.2	-1.9	-1.0
Depression (Nagel 2018)	0.3	0.5	1.4	-1.2	-0.7	-0.9	-0.3	-0.8
Neuroticism (Nagel 2018)	0.3	0.6	3.5	0.5	-0.5	0.6	-1.9	0.1
Alzheimer’s Disease (in father)	0.3	0.3	1.0	-1.0	-0.3	-0.9	0.1	-0.6
Age at First Birth	0.3	0.5	1.7	-0.3	1.3	0.9	-0.2	-0.9
Neuroticism (2016)	0.3	0.4	1.6	-0.6	-0.8	0.0	-1.3	0.5
Medication: Co-codamol	0.3	0.4	2.2	-0.5	0.4	-0.4	1.5	0.1
Diabetes (mother)	0.3	0.4	2.2	0.4	0.0	1.5	-0.9	0.1
Leg fat-free mass (left)	0.3	1.7	6.3	1.7	-0.5	-0.3	-2.5	-1.4
Impedance of leg (left)	0.3	1.4	3.7	-1.9	1.2	1.4	0.5	1.6
Leg predicted mass (left)	0.3	1.7	6.6	1.7	-0.6	-0.3	-2.6	-1.5
Trunk fat mass	0.3	1.2	4.2	-1.9	-0.5	-2.0	0.1	-0.8
Had other major operations	0.3	0.4	1.2	-1.1	0.4	-0.9	-0.9	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.7	0.5	-1.6	0.7	0.4	1.0
Allergy	0.3	0.6	1.7	-0.1	-1.0	-1.3	-0.2	-1.2
Alcohol intake versus 10 years previously	0.3	0.5	1.5	-0.9	1.2	-0.7	0.5	0.7
Worrier / anxious feelings	0.3	0.6	2.8	0.2	-0.0	-0.9	-1.7	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.4	0.3	1.2	-0.6	-0.4	-0.8
Impedance of arm (left)	0.3	1.5	3.7	-1.9	1.3	1.7	0.7	1.4
Peak expiratory flow (PEF)	0.3	0.7	2.8	0.5	1.1	1.7	-0.7	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.5	-0.0	-0.1	-0.9	-1.2	0.3
Medication: Paracetamol	0.3	0.4	1.6	-0.5	0.4	-0.8	0.6	-1.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.4	0.3	-1.6	-0.6	0.9	-0.4
Worry too long after embarrassment	0.3	0.5	1.1	0.9	-0.7	0.2	-1.0	1.0
Whole body fat mass	0.3	1.1	4.8	-1.4	-0.5	-2.2	0.1	-0.7
Arm predicted mass (right)	0.3	1.7	8.1	1.7	0.0	-0.1	-2.8	-1.0
Leg fat-free mass (right)	0.3	1.6	6.4	1.8	-0.0	0.1	-2.5	-1.3
Long-standing illness, disability or infirmity	0.3	0.5	1.6	-1.0	-0.6	-0.6	-0.2	-1.3
Osteoporosis (self-reported)	0.3	0.4	1.9	-0.1	0.2	0.8	0.3	1.4
Leg predicted mass (right)	0.3	1.6	6.5	1.7	-0.0	0.0	-2.6	-1.3
Hearing aid user	0.3	0.3	1.4	-0.0	-0.7	0.6	-0.1	-1.2
Commuting to job workplace: Public transport	0.3	0.4	1.0	-0.9	0.2	-1.0	-0.8	-0.1
Risk taking	0.3	0.5	1.2	-0.1	-1.1	-0.8	1.1	0.4
Diastolic blood pressure, automated reading	0.3	1.0	2.6	0.3	1.5	-1.3	-1.6	0.1
Myopia	0.3	0.5	1.5	0.8	0.9	0.2	1.2	-0.6
Schizophrenia (2018)	0.2	0.5	1.6	1.3	-0.9	-0.6	0.2	0.7
Body Mass Index (BMI) (2010)	0.2	0.3	1.5	-0.1	-0.5	-1.2	0.1	0.6
Schizophrenia (2014)	0.2	0.5	3.1	1.8	-0.2	0.2	0.4	0.4
Blood Red Count	0.2	1.8	8.2	-2.9	0.7	-2.0	-0.2	0.2
Tanning	0.2	2.9	9.5	-0.4	-2.7	-1.6	3.1	-0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.9	-0.8	0.4	-1.0	-0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.4	-0.3	-0.4	0.0	-1.2	-0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.8	-0.1	-0.6	0.0	0.6	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	0.2	0.5	-0.1	0.8	0.8
Medication for hormone replacement therapy	0.2	0.2	0.9	-0.1	-0.3	-0.4	0.2	0.9
Impedance of leg (right)	0.2	0.8	2.4	-1.5	0.5	1.3	0.5	1.1
Medication: Atenolol	0.2	0.2	1.1	-0.3	-0.5	0.1	0.4	-1.1
Hearing difficulty/problems with background noise	0.2	0.4	2.5	-0.1	-0.0	0.1	1.6	0.3
Heart attack	0.2	0.2	1.1	-0.4	-1.1	-0.7	0.1	0.1
Pain all over the body in last month	0.2	0.2	0.7	0.3	-0.8	-0.7	-0.5	0.4
Weight	0.2	0.9	2.4	0.1	-0.8	-1.1	-1.5	-1.6
Impedance of arm (right)	0.2	0.9	2.7	-1.6	0.6	1.5	0.4	0.8
Hip circumference	0.2	0.9	2.1	-0.8	-0.3	-1.4	-1.4	-1.3
Mouth/teeth dental problems: Dentures	0.2	0.3	1.8	-0.5	0.2	-0.2	1.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.9	1.4	-0.7	0.6	-0.6	-0.6
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.4	-0.3	-0.8	-0.7	0.5
Medication: Amlodipine	0.2	0.3	1.1	-0.3	0.4	-1.1	-0.7	-0.3
Age at first live birth	0.2	0.3	1.3	0.4	0.6	-0.1	1.1	0.1
Emphysema/chronic bronchitis	0.2	0.3	0.8	-0.7	0.7	-0.4	0.2	0.9
Alcohol intake frequency.	0.2	0.6	3.2	0.1	1.8	0.1	0.0	0.9
Had major operations	0.2	0.3	1.4	-0.0	-0.4	0.4	0.2	-1.2
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.3	0.6	0.6	0.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.0	-0.1	-0.7	-1.0	-0.6	-0.1
Osteoarthritis (self-reported)	0.2	0.3	1.5	-0.3	-0.0	-0.6	-1.2	0.3
Medication: Gliclazide	0.2	0.3	1.7	-1.3	0.3	0.1	-0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.2	1.1	0.9	0.9	0.2	0.5
Number of self-reported non-cancer illnesses	0.2	0.3	1.3	-0.9	0.6	-0.0	-1.1	-0.1
Guilty feelings	0.2	0.3	1.5	0.6	0.3	-0.1	-0.5	1.2
Medication: Blood pressure	0.2	0.4	1.5	-1.2	0.6	-0.0	-0.0	-1.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.3	-0.4	-1.1	-0.6	0.5	-0.3
Unable to work because of sickness or disability	0.2	0.3	1.0	-0.1	0.0	-0.5	1.0	-0.9
Basal cell carcinoma (self-reported)	0.2	0.3	1.8	0.2	0.3	-1.3	0.2	0.3
LDL Cholesterol	0.1	0.1	0.5	-0.7	-0.3	-0.5	-0.3	0.2
Triglycerides	0.1	0.2	0.4	-0.5	-0.7	-0.6	0.0	0.6
Hair Pigment	0.1	4.1	15.5	2.1	1.9	3.9	0.2	2.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	0.1	0.0	-0.5	-0.7	0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.8	-0.1	0.4	-0.9	0.1	-0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.9	1.4	-0.5	0.2	-0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.2	-0.2	0.7	-0.6	-0.4
Loud music exposure frequency	0.1	0.1	0.3	0.3	0.0	-0.6	-0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	1.0	-0.2	-0.1	0.1	-0.1	-1.0
Headache pain in last month	0.1	0.1	0.5	-0.7	0.1	0.2	-0.5	-0.1
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.6	-0.2	0.1	0.1	-0.6
Average weekly champagne plus white wine intake	0.1	0.2	0.7	-0.8	0.2	0.3	-0.1	0.6
Miserableness	0.1	0.2	1.2	0.2	0.2	-0.5	-1.1	-0.3
Age started oral contraceptive pill	0.1	0.1	0.4	0.6	0.4	-0.0	0.1	-0.6
Pain experienced in last month	0.1	0.1	0.6	-0.2	-0.2	-0.1	-0.5	-0.8
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.9	-0.2	-0.9	-0.4	0.1	-0.1
Heart disease (siblings)	0.1	0.1	0.6	0.1	-0.3	-0.3	-0.8	0.0
Medication: Cholesterol lowering	0.0	0.0	0.1	0.1	0.3	-0.0	-0.1	0.3
Hair/balding pattern: Pattern 4	0.0	0.0	0.3	-0.1	0.5	0.2	-0.1	0.1
Age at last live birth	0.0	0.1	0.2	0.0	0.1	-0.3	0.5	-0.2
Number of operations (self-reported)	0.0	0.1	0.2	0.4	0.3	-0.4	0.0	-0.0

Hub : Genes

ZNF850

Models

Trait associations