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chr19:48,464,978-50,767,440

Best TWAS P=2.15e-10 · Best GWAS P=2.48e-10 conditioned to 0.000452

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEC1	0.16	0.11	lasso	4	0.11	2.1e-12	5.7	-6.4	2.2e-10	0.53	0.07	0.93	TRUE
21	METSIM	Adipose	PRR12	0.06	0.06	enet	10	0.06	9.4e-09	6.0	6.2	4.9e-10	0.00	0.00	1.00	TRUE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FUT2	0.08	0.12	lasso	4	0.11	2.5e-05	-6.3	6.3	2.5e-10	-1.00	0.00	0.99	FALSE
3	GTEx	Brain Cerebellar Hemisphere	PRR12	0.27	0.12	lasso	5	0.10	2.0e-03	5.9	6.1	1.2e-09	-0.02	0.01	0.89	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	NTN5	0.02	0.01	enet	11	0.01	7.6e-04	-5.0	-6.1	1.2e-09	0.80	0.01	0.91	FALSE
4	GTEx	Brain Cerebellum	PRR12	0.36	0.33	lasso	6	0.31	6.8e-10	5.9	6.0	1.5e-09	-0.01	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	FUT2	0.14	0.16	lasso	8	0.14	4.9e-10	-6.3	6.0	1.8e-09	-0.99	0.00	1.00	FALSE
1	GTEx	Adipose Subcutaneous	PRR12	0.11	0.10	lasso	1	0.09	1.0e-07	6.0	6.0	1.9e-09	0.00	0.00	1.00	FALSE
11	GTEx	Liver	PRRG2	0.23	0.10	lasso	2	0.12	3.1e-04	6.0	6.0	1.9e-09	0.01	0.00	0.98	FALSE
10	GTEx	Esophagus Muscularis	CTB-33G10.11	0.09	0.00	lasso	4	0.00	2.7e-01	5.3	6.0	2.0e-09	-0.03	0.01	0.90	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	PRRG2	0.05	0.05	lasso	2	0.02	1.9e-02	6.0	-6.0	2.1e-09	-0.01	0.00	0.91	FALSE
9	GTEx	Esophagus Muscularis	PRR12	0.19	0.16	lasso	3	0.16	6.4e-10	6.0	6.0	2.5e-09	0.01	0.00	1.00	FALSE
13	GTEx	Nerve Tibial	PRR12	0.20	0.18	lasso	3	0.17	7.4e-12	6.0	5.9	2.7e-09	0.00	0.00	1.00	FALSE
12	GTEx	Lung	PRR12	0.13	0.11	lasso	2	0.10	5.8e-08	6.0	5.9	2.8e-09	0.00	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEC1	0.14	0.13	lasso	2	0.13	1.6e-14	5.9	-5.9	3.8e-09	0.40	0.05	0.95	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC1	0.06	0.05	enet	2	0.06	1.9e-06	5.7	-5.9	3.9e-09	0.41	0.07	0.92	FALSE
5	GTEx	Cells Transformed fibroblasts	RASIP1	0.19	0.14	lasso	6	0.20	6.1e-15	-6.3	-5.8	5.1e-09	0.96	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NTN5	0.11	0.02	blup	41	0.07	1.2e-04	3.6	-5.8	5.9e-09	0.77	0.02	0.79	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	FUT2	0.18	0.22	enet	12	0.18	6.8e-11	-5.5	5.8	8.7e-09	-0.96	0.03	0.97	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	FUT2	0.05	0.06	blup	52	0.06	8.6e-07	-6.3	5.7	9.4e-09	-0.93	0.00	0.99	FALSE
14	GTEx	Pancreas	PRR12	0.19	0.17	lasso	2	0.16	3.8e-07	6.0	5.7	9.7e-09	0.00	0.00	1.00	FALSE
17	GTEx	Skin Sun Exposed Lower leg	NTN5	0.11	0.09	enet	18	0.05	6.2e-05	-6.3	-5.7	1.1e-08	0.90	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Esophageal Carcinoma	FUT2	0.33	0.27	lasso	3	0.24	3.9e-08	5.6	5.7	1.1e-08	-0.87	0.02	0.97	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FUT2	0.11	0.22	blup	52	0.22	6.3e-24	-6.3	5.7	1.3e-08	-0.92	0.00	1.00	FALSE
6	GTEx	Colon Sigmoid	PRR12	0.20	0.01	lasso	8	0.00	4.9e-01	6.0	5.7	1.5e-08	0.01	0.02	0.57	FALSE
8	GTEx	Esophagus Mucosa	PRR12	0.23	0.11	lasso	6	0.21	3.2e-14	3.2	5.6	2.2e-08	-0.02	0.02	0.98	FALSE
7	GTEx	Colon Transverse	PRR12	0.27	0.09	enet	8	0.16	4.7e-08	3.2	5.6	2.7e-08	-0.05	0.12	0.88	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	SPHK2	0.06	0.06	lasso	5	0.06	1.0e-06	5.7	5.5	3.4e-08	-0.37	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FUT2	0.05	0.08	lasso	2	0.08	6.7e-09	-5.4	5.5	3.5e-08	-0.95	0.02	0.98	FALSE
16	GTEx	Skin Sun Exposed Lower leg	PRRG2	0.23	0.18	lasso	3	0.21	1.3e-17	5.8	5.5	4.1e-08	0.03	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	FUT2	0.09	0.12	blup	52	0.12	4.2e-14	-5.0	5.5	4.4e-08	-0.92	0.02	0.98	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	RASIP1	0.02	0.02	blup	56	0.03	3.8e-07	-5.2	-5.4	5.1e-08	0.89	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Soft Tissue Sarcoma	SEC1	0.31	0.17	lasso	6	0.17	1.4e-10	5.7	-5.4	5.6e-08	0.36	0.12	0.88	FALSE
2	GTEx	Artery Aorta	PRR12	0.21	0.13	lasso	5	0.15	7.6e-09	4.8	5.4	6.4e-08	0.02	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC1	0.05	0.05	enet	5	0.05	2.2e-11	4.9	-5.3	8.9e-08	0.39	0.25	0.75	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	NTN5	0.11	0.07	blup	43	0.09	2.6e-09	-5.0	-5.3	1.3e-07	0.88	0.08	0.92	FALSE
25	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FUT2	0.10	0.02	blup	55	0.06	6.8e-04	-5.0	5.3	1.4e-07	-0.90	0.02	0.98	FALSE
19	GTEx	Testis	NTN5	0.16	0.02	enet	23	0.06	9.6e-04	-5.5	-5.2	1.8e-07	0.66	0.04	0.63	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	NTN5	0.05	0.04	lasso	2	0.02	6.7e-04	-5.2	-5.2	1.8e-07	0.92	0.02	0.98	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	NTN5	0.19	0.07	lasso	5	0.08	2.5e-05	-5.5	-5.2	1.9e-07	0.91	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	FUT2	0.06	0.04	blup	54	0.06	1.1e-06	5.6	5.2	2.2e-07	-0.87	0.02	0.98	FALSE
18	GTEx	Skin Sun Exposed Lower leg	NOSIP	0.13	0.12	lasso	1	0.11	3.2e-09	5.2	5.2	2.3e-07	-0.05	0.25	0.75	FALSE
20	GTEx	Thyroid	NTN5	0.14	0.02	enet	26	0.04	4.4e-04	-5.5	-5.2	2.3e-07	0.65	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Rectum Adenocarcinoma	FUT2	0.26	0.28	lasso	10	0.22	5.2e-06	-5.2	5.2	2.4e-07	-0.91	0.02	0.97	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRR12	0.09	0.03	lasso	6	0.06	4.0e-04	3.2	5.1	3.0e-07	-0.01	0.01	0.86	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRR12	0.03	0.00	blup	30	0.01	1.1e-02	6.0	5.1	3.0e-07	-0.01	0.01	0.76	FALSE