TWAS hub - SPHK2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0290	2.4e-03	0.025	0.026	0.008	0.025	0.016	4.7e-04	3.6e-04	3.4e-02	4.6e-04	3.8e-03
2	YFS	Blood	0.0678	0.0165	8.3e-11	0.041	0.036	0.057	0.046	0.056	1.6e-13	6.1e-12	4.4e-18	9.9e-15	8.2e-18
3	TCGA	Thyroid Carcinoma	0.0620	0.0230	7.2e-05	0.065	0.046	0.050	NA	0.063	6.4e-07	2.6e-05	1.1e-05	NA	1.0e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Alcohol intake frequency.	8.4	19.6	25.9	5.1	4.2	3.9
Bilateral oophorectomy (both ovaries removed)	6.3	7.2	8.4	-2.3	-2.8	-2.9
High cholesterol (Self-reported)	5.9	10.4	16.1	-4.0	-2.7	-2.8
Chronotype (morning person)	5.0	11.6	19.7	4.4	3.0	2.4
Fractured/broken bones in last 5 years	5.0	6.5	8.0	2.1	2.7	2.8
Alcohol drinker status: Previous	4.7	5.3	5.9	2.3	2.2	2.4
Blood White Count	4.4	32.8	47.2	-4.1	-5.8	-6.9
Comparative height size at age 10	4.3	23.7	30.4	4.3	4.7	5.5
Verbal and Numeric Reasoning (VNR)	4.0	9.5	11.5	-3.4	-3.1	-2.7
Comparative body size at age 10	4.0	11.1	13.2	3.6	2.9	3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	4.0	5.2	11.4	0.7	1.9	3.4
Suffer from ‘nerves’	3.9	6.2	8.1	1.9	2.8	2.6
Age when periods started (menarche)	3.7	8.8	14.4	-2.9	-1.9	-3.8
Fluid intelligence score	3.7	7.7	10.6	-3.0	-3.2	-1.9
Prospective memory result	3.7	4.6	6.7	1.8	1.9	2.6
Ever used hormone-replacement therapy (HRT)	3.5	4.5	11.8	1.3	0.2	3.4
Medication: Simvastatin	3.2	4.7	8.8	-1.1	-3.0	-2.0
Alcohol intake versus 10 years previously	3.2	4.8	10.2	3.2	1.6	1.3
Qualifications: O levels/GCSEs or equivalent	3.1	4.9	9.6	-3.1	-1.6	-1.7
Number of children fathered	3.1	3.5	5.1	1.8	2.3	1.5
Osteoarthritis (self-reported)	3.1	4.1	7.7	2.8	0.6	2.0
Waist Hip Ratio (WHR)	2.9	12.9	23.5	-2.6	-2.9	-4.8
Peak expiratory flow (PEF)	2.9	6.7	10.3	2.6	1.8	3.2
Crohns Disease (2017)	2.8	6.2	9.4	-3.1	-2.2	-2.1
Hypothyroidism (self reported)	2.8	6.4	8.3	-2.9	-1.9	-2.7
Medication: Lansoprazole	2.8	3.2	5.2	2.3	-1.7	1.2
Systolic Blood Pressure	2.7	13.4	27.9	-5.3	-3.2	-1.5
Qualifications: College or University degree	2.6	8.2	13.7	-3.7	-1.2	-3.1
Reaction Time	2.5	4.8	8.4	0.9	2.9	2.2
Tinnitus: Yes, but not now, but have in the past	2.5	2.6	5.2	2.3	0.7	1.5
Systolic blood pressure, automated reading	2.4	6.9	13.2	-3.6	-2.3	-1.6
Qualifications: None of the above	2.4	5.2	9.6	3.1	0.7	2.4
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	5.0	-2.2	-0.5	-1.8
Pack years of smoking	2.4	3.6	5.2	1.7	1.6	2.3
Neuroticism score	2.3	4.7	5.7	2.0	2.4	2.1
Medication: Cholesterol lowering	2.3	3.5	6.6	-2.6	-1.7	-0.9
Migraine (self-reported)	2.3	2.9	8.6	2.9	-0.0	0.1
Cardiovascular Disease	2.2	7.3	15.3	-3.9	-2.4	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	3.9	1.8	2.0	1.7
Average weekly red wine intake	2.2	3.3	4.5	-2.1	-1.3	-1.9
Blood Platelet Count	2.1	24.7	43.7	-6.6	-1.3	-5.3
Illnesses of father: High blood pressure	2.1	2.5	3.8	-1.9	-0.7	-1.8
Intelligence (Savage-Jansen 2018)	2.0	6.2	8.0	-2.5	-2.8	-2.1
LDL Cholesterol	2.0	3.2	9.6	-3.1	0.0	0.0
Lupus	2.0	3.0	4.6	0.7	2.2	1.9
Fed-up feelings	2.0	3.7	7.8	2.8	1.5	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	13.1	2.1	1.2	3.6
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	6.1	-1.4	-1.8	-2.5
Age at last live birth	2.0	2.9	5.4	-2.3	-1.3	-1.3
Rheumatoid Arthritis	1.9	2.6	3.1	1.8	1.6	1.4
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	12.8	2.1	1.5	3.6
Length of working week for main job	1.9	2.1	4.5	2.1	-0.3	1.3
Hearing difficulty/problems: Yes	1.8	2.7	5.2	1.1	1.3	2.3
Supplements: Zinc	1.8	2.0	2.6	1.6	1.0	1.5
High blood pressure (mother)	1.8	2.5	7.0	-2.6	0.6	-0.3
Father’s age at death	1.8	2.4	7.0	-0.5	2.6	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.2	3.9	2.0	-0.5	1.5
Diastolic blood pressure, automated reading	1.8	5.5	6.8	-2.6	-2.0	-2.4
Myopia	1.8	2.6	3.9	1.4	1.4	2.0
Pack years adult smoking proportion	1.7	2.7	4.1	1.4	1.3	2.0
Worrier / anxious feelings	1.7	3.1	4.7	0.9	2.2	2.0
Blood clot in the leg (DVT)	1.7	2.2	3.0	-1.6	-1.7	-1.0
Medication: Ventolin 100micrograms inhaler	1.7	2.2	3.3	1.8	-1.1	-1.4
Mean time to correctly identify matches	1.7	3.2	7.3	0.2	2.7	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	3.1	0.1	1.7	1.8
Handedness (chirality/laterality): Left-handed	1.7	2.1	3.2	1.5	0.8	1.8
Bipolar Disorder (2018)	1.6	2.5	4.4	-2.1	-1.8	0.0
Worry (Nagel 2018)	1.6	3.5	3.5	1.9	1.8	1.9
Diabetes (father)	1.6	2.0	5.1	2.3	0.9	0.0
Alcohol usually taken with meals	1.6	2.6	5.4	-2.3	-1.4	-0.8
Qualifications: A levels/AS levels or equivalent	1.6	3.6	7.9	-2.8	0.3	-1.7
Forced vital capacity (FVC), Best measure	1.6	6.0	14.6	1.5	1.1	3.8
Knee pain experienced in last month	1.6	2.5	2.7	1.6	1.5	1.6
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.0	-1.7	-1.7	-0.8
Breast Cancer	1.5	3.6	6.5	2.5	1.5	1.5
Height	1.5	29.4	41.3	5.2	4.4	6.4
Sitting height	1.5	11.0	16.6	2.7	3.0	4.1
Number of incorrect matches in round	1.5	2.4	6.4	2.5	0.9	0.0
Forced vital capacity (FVC)	1.5	5.8	13.5	1.5	1.3	3.7
Pulse rate	1.5	2.5	5.7	-2.4	-0.7	-1.1
Standing height	1.5	15.3	21.7	3.8	3.2	4.7
Pulse wave peak to peak time	1.5	1.8	4.2	0.1	1.1	2.0
Friendships satisfaction	1.5	1.9	3.1	-1.8	-1.4	-0.6
Medication: Gliclazide	1.5	1.7	2.5	0.4	1.5	1.6
Number of self-reported non-cancer illnesses	1.5	2.5	4.6	-1.2	-2.1	-1.2
Ever taken oral contraceptive pill	1.5	1.7	2.5	0.7	-1.4	-1.6
Prostate Cancer	1.4	2.0	5.8	-2.4	-0.5	-0.1
Average weekly spirits intake	1.4	1.7	2.8	1.7	0.6	1.4
Breastfed as a baby	1.4	1.7	4.2	-2.1	0.7	0.7
Medication for cholesterol	1.4	2.2	5.5	2.3	-0.4	-0.9
Average weekly champagne plus white wine intake	1.4	1.9	4.9	-2.2	0.3	-0.9
Cholesterol lowering medication	1.4	2.0	2.7	-1.6	-0.9	-1.6
Neuroticism	1.3	3.3	3.8	1.7	1.8	1.9
Exposure to tobacco smoke at home	1.3	1.5	2.5	-0.2	1.6	1.4
Tense / ‘highly strung’	1.3	2.2	3.8	1.1	1.2	2.0
Medication: Omeprazole	1.3	1.6	2.4	1.5	0.8	1.3
Irritability	1.3	2.2	4.2	0.4	1.5	2.1
Pain experienced in last month	1.3	2.1	3.7	-1.3	-0.9	-1.9
Irritable Bowel Disease (IBD)	1.2	2.7	3.2	-1.8	-1.6	-1.6
Diabetes (mother)	1.2	1.5	3.3	1.8	0.5	-1.0
Medication: Atenolol	1.2	1.5	2.2	1.0	-1.5	-1.1
Neck or shoulder pain in last month	1.2	1.7	2.8	1.4	0.6	1.7
Loneliness, isolation	1.2	1.6	2.1	1.4	1.2	1.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.8	-1.0	1.7	0.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.2	1.3	1.5	0.9
Medication: Bendroflumethiazide	1.2	1.8	4.7	-2.2	0.0	-0.8
Medication: Lisinopril	1.2	1.5	3.6	-1.9	-0.7	-0.6
Depressed Affect (Nagel 2018)	1.1	2.4	4.7	2.2	1.1	1.1
Neuroticism (Nagel 2018)	1.1	2.6	3.7	1.3	1.9	1.6
Medication: Levothyroxine sodium	1.1	1.9	2.5	-1.6	-0.9	-1.5
Nervous feelings	1.1	2.0	3.6	0.4	1.9	1.5
Hearing difficulty/problems with background noise	1.1	1.7	2.6	0.3	1.6	1.6
Had menopause	1.1	1.4	2.5	1.2	-0.3	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.5	1.3	1.6	1.1
Hair/balding pattern: Pattern 3	1.1	1.6	4.6	-0.3	0.4	2.1
Exposure to tobacco smoke outside home	1.1	1.4	3.0	1.7	-0.1	1.1
Mood swings	1.1	1.9	3.5	1.2	0.8	1.9
Eye problems/disorders: Glaucoma	1.1	1.3	2.6	1.6	-1.0	-0.7
Medication: Blood pressure	1.1	2.0	2.8	-1.7	0.6	1.7
Ever depressed for a whole week	1.1	1.3	2.2	-1.1	0.8	1.5
Bipolar Disorder or Schizophrenia	1.0	2.4	4.5	-2.1	-1.7	0.0
Schizophrenia (2014)	1.0	2.2	6.0	-2.5	-0.8	0.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.1	-1.4	-0.2	-1.4
Financial difficulties in last 2 years	1.0	1.4	3.2	-0.7	-0.6	-1.8
Pulse wave Arterial Stiffness index	1.0	1.1	2.9	0.1	-0.7	-1.7
Headache pain in last month	1.0	1.8	2.0	1.4	1.2	1.4
Glaucoma (self-reported)	1.0	1.2	2.0	-0.3	-1.2	-1.4
Eye problems/disorders: None of the above	1.0	1.2	2.7	-0.3	1.6	0.9
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.1	-0.2	-1.8	0.6
Supplements: Vitamin C	1.0	1.2	3.2	1.8	-0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.7	-0.2	-1.9	-1.1
Ever smoked	1.0	1.7	5.2	2.3	-0.2	0.1
Mean Putamen Volume	0.9	1.0	3.1	1.8	0.0	0.2
Primary Biliary Cirrhosis	0.9	1.3	2.2	0.3	1.5	1.2
Lung FEV1/FVC ratio	0.9	4.7	6.0	2.5	2.0	2.1
Ever had hysterectomy (womb removed)	0.9	1.0	1.7	1.1	-0.1	1.3
Hair/balding pattern: Pattern 2	0.9	1.1	2.1	1.4	1.1	-0.3
Illnesses of mother	0.9	1.2	3.4	1.9	0.2	-0.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.8	1.7	-0.5	0.5
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.3	-1.2	-1.0	-1.0
Age at first live birth	0.9	1.6	2.5	-1.6	-0.5	-1.4
Medication: Atorvastatin	0.9	1.1	3.3	-1.8	-0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.8	1.3	0.5	1.1
Fasting Glucose	0.8	0.9	1.6	-0.6	-1.3	-0.9
Smoking Status	0.8	2.0	3.0	1.5	-0.8	-1.7
Sensitivity / hurt feelings	0.8	1.3	3.0	0.8	1.7	0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.9	1.4	0.3	-0.8
Medication for hormone replacement therapy	0.8	0.9	1.8	-0.6	-1.4	0.6
Townsend deprivation index at recruitment	0.8	1.1	2.9	1.7	0.5	0.6
Lung cancer (father)	0.8	0.9	1.5	1.2	0.1	1.1
High blood pressure (siblings)	0.8	1.1	2.6	-0.9	0.1	1.6
Chest pain or discomfort	0.8	1.1	3.1	-0.1	-1.8	0.4
Mineral and other dietary supplements	0.8	1.1	2.1	-1.0	-0.5	-1.4
Commuting to job workplace: Public transport	0.8	1.0	2.8	0.3	1.7	-0.3
Alcohol drinker status: Never	0.8	1.0	1.9	1.4	1.0	0.2
HbA1C	0.7	0.8	1.4	1.2	-0.9	-0.3
Relative age of first facial hair	0.7	1.5	3.6	0.1	-1.0	-1.9
Severe depression (siblings)	0.7	0.8	2.0	-0.2	0.5	1.4
Multivitamins +/- minerals	0.7	0.9	1.5	-0.7	1.2	0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.3	-0.0	-0.5	-1.5
Happiness	0.7	0.9	1.4	0.8	0.8	1.2
Noisy workplace	0.7	0.9	2.0	1.4	-0.1	0.8
Depression (self-reported)	0.7	0.9	2.0	-1.4	0.0	-0.8
Birth weight	0.7	1.5	3.3	1.8	0.4	1.1
Arm fat-free mass (right)	0.7	3.8	5.7	2.0	1.2	2.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.3	-0.6	1.1	0.9
Angina (self-reported)	0.7	0.9	2.4	1.6	-0.4	-0.3
Heart disease (mother)	0.7	0.9	1.5	0.3	1.0	1.2
Ever had bowel cancer screening	0.7	0.8	1.8	-0.2	0.8	1.3
Wears glasses or contact lenses	0.7	0.8	1.1	0.8	-0.8	1.1
Mother’s age at death	0.7	0.9	2.2	-0.5	0.5	-1.5
Commuting to job workplace: Cycle	0.7	0.9	2.5	-0.1	1.6	0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.3	1.1	-0.9	0.6
Crohns Disease (2012)	0.6	1.0	3.1	-1.8	0.0	0.0
Respiratory disease	0.6	1.2	2.8	1.7	-0.8	0.4
Number of treatments/medications taken	0.6	1.1	3.0	0.4	0.5	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	1.1	1.0	0.9	0.8
Past tobacco smoking	0.6	1.1	2.2	-1.5	0.6	0.9
Mouth/teeth dental problems	0.6	0.9	1.4	1.2	0.7	0.8
Heart attack	0.6	0.7	1.0	1.0	-1.0	0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.6	0.4	0.4	1.3
Medication: Paracetamol	0.6	0.9	1.0	0.9	1.0	1.0
Medication: Amlodipine	0.6	0.9	1.2	0.8	0.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	-1.2	0.7	-0.4
Health satisfaction	0.6	0.7	1.4	0.9	0.1	1.2
Arm predicted mass (right)	0.6	3.1	4.7	1.9	0.9	2.2
Pulse rate, automated reading	0.6	1.9	3.9	-2.0	1.0	-0.8
Number of full sisters	0.6	0.7	1.7	-0.4	-0.5	-1.3
Smoking status: Previous	0.6	1.0	1.2	0.8	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.6	-0.9	0.5	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.4	-1.2	0.6	0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.7	0.9	0.9	-0.9	0.7
Major Depression (MDD)	0.5	0.6	1.7	-1.3	0.0	0.0
Lung FVC	0.5	2.6	7.6	0.3	-0.0	2.8
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.7	0.5	1.3	0.0
Angina	0.5	0.7	1.7	1.3	-0.4	-0.4
Vitamin and mineral supplements	0.5	0.6	1.5	-0.6	-0.4	-1.2
Current tobacco smoking	0.5	0.9	2.2	1.5	0.0	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	1.4	0.2	1.2	0.8
High blood pressure	0.5	1.5	2.8	-1.7	0.2	1.3
Impedance of leg (left)	0.5	2.5	3.0	1.4	1.7	1.5
Allergy	0.5	1.1	2.8	-0.4	1.7	0.6
Medication: Ramipril	0.5	0.6	1.1	-0.7	0.5	1.1
Arm fat percentage (right)	0.5	2.1	4.3	-0.9	-1.1	-2.1
Number of live births	0.5	0.7	1.7	-0.4	-1.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.8	0.7	0.9	0.9
Pulse wave reflection index	0.5	0.6	1.8	1.4	0.0	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.1	0.7	1.4	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	1.2	0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	0.4	0.6	1.1
Hypertension (Self-reported)	0.5	1.5	3.6	-1.9	-0.1	0.9
Breast cancer (self-reported)	0.5	0.6	1.1	0.1	-0.9	1.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.1	-1.0	0.2	-0.9
Smoking status: Current	0.5	0.7	2.1	1.4	0.1	-0.4
Miserableness	0.5	0.8	1.0	0.9	1.0	0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	1.1	0.7	0.3
Supplements: Calcium	0.5	0.5	1.0	0.3	-1.0	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	0.8	-0.5	-0.9	0.8
Schizophrenia (2018)	0.4	0.9	1.7	-1.3	-1.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.5	1.2	0.0	0.0
Triglycerides	0.4	0.7	2.1	-1.5	0.0	0.0
Blood Eosinophil Count	0.4	2.9	5.8	-1.5	-2.4	-0.7
Hand grip strength (right)	0.4	1.0	1.3	-0.8	-1.1	-1.0
Relative age voice broke	0.4	0.6	1.8	-0.3	-0.3	-1.3
Taking other prescription medications	0.4	0.7	1.5	1.2	0.2	0.6
Serious illness, injury or assault to yourself	0.4	0.5	1.2	0.4	-1.1	0.4
Stomach or abdominal pain in last month	0.4	0.5	1.0	0.5	1.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.8	0.6	-0.7	0.9
Pain all over the body in last month	0.4	0.5	0.6	0.8	-0.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.7	0.9	-0.3	-0.8
Illnesses of siblings	0.4	0.5	0.8	0.7	0.5	-0.9
Trunk fat-free mass	0.4	2.4	4.0	1.6	0.9	2.0
Hip circumference	0.4	1.9	3.9	2.0	0.7	1.1
Asthma	0.4	0.8	1.6	1.3	-0.8	0.3
Trunk predicted mass	0.4	2.4	3.9	1.6	0.9	2.0
Hair/balding pattern: Pattern 4	0.4	0.9	1.1	0.9	1.0	1.0
Birth weight of first child	0.4	0.7	1.9	0.1	0.4	1.4
Wheeze or whistling in the chest in last year	0.4	0.6	1.6	0.5	-1.3	0.1
Medication: Blood pressure	0.4	0.7	2.1	0.3	-1.4	0.0
Medication: Ibuprofen	0.4	0.4	0.7	-0.0	0.8	0.8
Had major operations	0.4	0.5	0.8	0.7	0.9	0.2
Family relationship satisfaction	0.4	0.5	1.2	-1.1	0.1	0.5
Asthma (self-reported)	0.4	0.8	1.3	1.0	-1.1	-0.1
Guilty feelings	0.4	0.7	1.0	-0.3	0.9	1.0
Average weekly beer plus cider intake	0.4	0.6	0.7	-0.9	-0.8	0.6
Unable to work because of sickness or disability	0.4	0.5	0.8	0.4	0.9	-0.7
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.2	1.5	-0.2	-1.1
Alzheimer’s Disease (in father)	0.3	0.3	0.5	-0.2	-0.6	-0.7
Age at First Birth	0.3	0.4	1.1	0.1	0.2	1.0
Blood Red Count	0.3	3.1	6.6	0.6	2.6	1.5
BMI	0.3	2.0	3.0	0.1	-1.7	-1.7
Allergy or Eczema	0.3	0.7	1.4	0.8	-1.2	-0.1
Medication: Co-codamol	0.3	0.3	0.9	0.9	0.4	0.0
Impedance of leg (right)	0.3	1.3	2.0	0.9	1.4	1.1
Average weekly fortified wine intake	0.3	0.4	1.0	0.0	1.0	0.3
Maternal smoking around birth	0.3	0.5	0.8	0.8	-0.9	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	0.6	-1.2	-0.5
Supplements: Glucosamine	0.3	0.4	0.8	0.9	0.5	0.1
Body mass index (BMI)	0.3	1.2	2.5	-0.3	-0.9	-1.6
Waist circumference	0.3	1.0	2.3	0.4	-0.8	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	1.1	0.3	0.4
Mouth/teeth dental problems: Dentures	0.3	0.4	0.6	-0.8	0.8	0.1
Loud music exposure frequency	0.3	0.3	0.6	-0.8	-0.3	-0.4
Leg fat percentage (right)	0.3	1.0	2.2	0.5	-0.6	-1.5
Number of full brothers	0.3	0.4	1.0	-0.5	-0.2	-1.0
Shortness of breath walking on level ground	0.3	0.4	1.1	1.0	-0.1	-0.3
Overall health rating	0.3	0.6	1.7	0.0	1.3	0.2
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.9	-0.7	-0.1
Whole body fat-free mass	0.3	1.9	2.7	1.6	0.6	1.6
Arm fat percentage (left)	0.3	1.0	2.3	-0.4	-0.8	-1.5
Long-standing illness, disability or infirmity	0.3	0.5	1.5	1.2	-0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.2	0.2	0.9
Qualifications: nursing, teaching	0.3	0.4	0.8	-0.5	0.9	0.4
Commuting to job workplace: Walk	0.3	0.3	0.6	0.0	0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.8	0.2	0.0	1.4
Whole body water mass	0.3	1.7	2.5	1.5	0.6	1.6
Hearing aid user	0.3	0.3	0.6	0.8	0.3	0.5
Financial situation satisfaction	0.3	0.4	0.9	0.0	-0.4	-0.9
Basal metabolic rate	0.3	1.6	2.3	1.5	0.6	1.4
Arm fat-free mass (left)	0.3	1.7	2.7	1.7	0.7	1.4
Age started oral contraceptive pill	0.3	0.4	0.7	0.9	-0.5	0.3
Arm predicted mass (left)	0.3	1.7	2.5	1.6	0.7	1.4
Depression (Nagel 2018)	0.2	0.3	0.8	0.9	0.3	0.4
Ulcerative Colitis (UC)	0.2	0.3	0.6	-0.3	-0.4	-0.8
Tanning	0.2	1.9	3.2	1.8	0.4	1.6
Medication: Metformin	0.2	0.2	0.3	-0.5	0.5	-0.4
Leg fat-free mass (left)	0.2	0.9	1.5	1.2	0.3	1.0
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.4	-0.2	0.6
Leg predicted mass (left)	0.2	0.9	1.5	1.2	0.3	1.0
Had other major operations	0.2	0.2	0.4	0.3	0.6	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	-0.2	1.1	-0.0
Weight	0.2	0.9	2.2	1.5	0.5	0.6
Time employed in main current job	0.2	0.2	0.5	-0.1	0.1	0.7
Impedance of arm (left)	0.2	0.8	1.4	0.2	1.2	1.0
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.7	0.0	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.2	-0.5	-0.8
Medication: Allopurinol	0.2	0.2	0.4	-0.6	-0.5	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.3	-0.5	-0.6
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.6	-0.7	0.3
Leg fat-free mass (right)	0.2	1.2	2.1	1.5	0.3	1.2
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.3	-0.3	-0.6
Leg predicted mass (right)	0.2	1.1	2.0	1.4	0.2	1.1
Leg fat percentage (left)	0.2	0.7	1.1	1.0	-0.3	-1.0
Number of operations (self-reported)	0.2	0.3	0.5	0.1	0.7	0.7
Risk taking	0.2	0.3	0.8	-0.9	-0.3	0.3
Heart disease (siblings)	0.2	0.2	0.5	0.1	0.4	0.7
Impedance of whole body	0.2	1.2	2.0	0.5	1.4	1.1
Leg fat mass (left)	0.2	0.6	1.7	1.3	0.1	-0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.3	-0.4	0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.2	-0.4	-0.1
Ovarian Cancer	0.1	0.1	0.2	-0.0	0.4	0.4
HDL Cholesterol	0.1	0.2	0.7	0.8	0.0	0.0
Neuroticism (2016)	0.1	0.1	0.2	0.5	0.3	0.2
Ulcerative Colitis	0.1	0.1	0.3	-0.4	-0.5	0.0
Heel T-Score	0.1	0.9	1.8	-0.8	0.5	-1.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.7	-0.2	-0.3
Hand grip strength (left)	0.1	0.2	0.4	0.7	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.5	0.8	0.0
Trunk fat mass	0.1	0.4	1.0	1.0	0.3	0.4
Impedance of arm (right)	0.1	0.3	0.7	-0.8	0.6	0.0
Arm fat mass (right)	0.1	0.4	1.0	-0.1	-0.3	-1.0
Gout (self-reported)	0.1	0.1	0.3	0.1	0.6	0.1
Body fat percentage	0.1	0.2	0.5	0.3	-0.3	-0.7
Worry too long after embarrassment	0.1	0.2	0.4	-0.1	0.4	0.7
Whole body fat mass	0.1	0.4	1.0	1.0	0.3	0.2
Leg fat mass (right)	0.1	0.6	1.1	1.1	-0.1	-0.8
Diabetes diagnosed by doctor	0.1	0.2	0.2	-0.4	0.5	0.3
Back pain experienced in last month	0.1	0.2	0.3	0.1	0.6	0.5
Osteoporosis (self-reported)	0.1	0.2	0.3	0.4	0.3	0.5
Arm fat mass (left)	0.1	0.2	0.6	0.2	-0.3	-0.7
Medication: Paracetamol	0.1	0.2	0.4	0.7	0.3	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.6	1.2	1.1	-0.1	0.8
Trunk fat percentage	0.0	0.1	0.2	0.5	0.0	-0.2
Diabetes (self-reported)	0.0	0.1	0.2	0.2	0.1	0.4
Falls in the last year	0.0	0.1	0.1	0.3	-0.0	0.2
Leg pain on walking	0.0	0.0	0.1	-0.1	-0.1	0.3
Medication: Aspirin	0.0	0.1	0.1	0.1	-0.3	-0.2
Medication: Aspirin	0.0	0.1	0.2	-0.0	-0.4	-0.1

Hub : Genes

SPHK2

Models

Trait associations