Best TWAS P=1.96e-24 · Best GWAS P=1.59e-25 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF638 | 0.06 | 0.01 | bslmm | 559 | 0.02 | 1.8e-03 | 10.2 | 7.2 | 8.9e-13 | 0.68 | 0.02 | 0.95 | FALSE |
2 | GTEx | Artery Aorta | ZNF638 | 0.25 | 0.07 | enet | 20 | 0.10 | 5.2e-06 | 10.1 | 10.2 | 2.0e-24 | 0.97 | 0.01 | 0.99 | TRUE |
3 | GTEx | Artery Tibial | ZNF638 | 0.10 | 0.06 | enet | 13 | 0.07 | 2.4e-06 | 10.3 | 9.1 | 7.8e-20 | 0.86 | 0.02 | 0.98 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | FAM136A | 0.31 | 0.12 | lasso | 7 | 0.16 | 5.6e-06 | 4.1 | 5.5 | 4.9e-08 | 0.03 | 0.06 | 0.92 | TRUE |
5 | GTEx | Cells Transformed fibroblasts | NFU1 | 0.10 | 0.07 | lasso | 2 | 0.03 | 2.0e-03 | 7.5 | -7.5 | 4.5e-14 | 0.06 | 0.00 | 0.99 | TRUE |
6 | GTEx | Colon Transverse | PCYOX1 | 0.13 | 0.01 | lasso | 3 | 0.00 | 2.7e-01 | -5.3 | -5.2 | 1.9e-07 | 0.00 | 0.02 | 0.90 | FALSE |
7 | GTEx | Nerve Tibial | GFPT1 | 0.13 | 0.01 | lasso | 4 | 0.02 | 1.8e-02 | -3.4 | 5.3 | 8.8e-08 | -0.12 | 0.18 | 0.33 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | PAIP2B | 0.14 | 0.07 | enet | 39 | 0.07 | 3.0e-06 | 7.6 | 6.0 | 2.0e-09 | 0.65 | 0.24 | 0.73 | FALSE |
9 | GTEx | Small Intestine Terminal Ileum | GFPT1 | 0.24 | 0.01 | enet | 19 | 0.03 | 8.5e-02 | -4.1 | 5.4 | 5.2e-08 | -0.08 | 0.08 | 0.09 | FALSE |
10 | GTEx | Thyroid | ZNF638 | 0.11 | 0.04 | enet | 13 | 0.06 | 1.3e-05 | 4.2 | 6.2 | 5.4e-10 | 0.64 | 0.06 | 0.92 | FALSE |
11 | METSIM | Adipose | PAIP2B | 0.05 | 0.03 | lasso | 9 | 0.03 | 5.0e-05 | 7.6 | 7.2 | 4.8e-13 | 0.73 | 0.71 | 0.21 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | GFPT1 | 0.09 | 0.01 | bslmm | 439 | 0.02 | 3.2e-04 | 5.9 | 5.1 | 2.9e-07 | -0.06 | 0.10 | 0.70 | FALSE |
13 | The Cancer Genome Atlas | Esophageal Carcinoma | ZNF638 | 0.12 | 0.08 | lasso | 1 | 0.07 | 2.2e-03 | 6.9 | 6.9 | 4.3e-12 | 0.74 | 0.05 | 0.66 | FALSE |
14 | The Cancer Genome Atlas | Glioblastoma Multiforme | CYP26B1 | 0.19 | 0.01 | lasso | 4 | 0.00 | 3.6e-01 | 4.5 | 6.0 | 2.5e-09 | 0.02 | 0.03 | 0.11 | TRUE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GFPT1 | 0.05 | 0.00 | blup | 67 | 0.02 | 5.9e-03 | -3.4 | 5.6 | 2.4e-08 | -0.12 | 0.03 | 0.39 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF638 | 0.08 | 0.05 | enet | 10 | 0.05 | 5.6e-06 | 10.2 | 9.0 | 2.7e-19 | 0.86 | 0.01 | 0.99 | FALSE |