TWAS hub - PNPT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.3610	0.0990	1.4e-04	0.163	NA	0.042	NA	0.026	5.5e-06	NA	1.7e-02	NA	4.8e-02
2	GTEx	Muscle Skeletal	0.1164	0.0345	7.7e-07	0.071	NA	0.070	NA	0.077	1.6e-07	NA	2.1e-07	NA	4.8e-08
3	NTR	Blood	0.0176	0.0071	1.3e-03	0.006	0.006	0.015	0.007	0.012	4.0e-03	2.8e-03	7.7e-06	1.4e-03	5.1e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.0575	0.0248	4.5e-03	0.013	0.011	0.002	-0.001	0.003	6.8e-03	1.1e-02	1.8e-01	4.7e-01	1.2e-01
5	YFS	Blood	0.0431	0.0133	8.9e-09	0.013	0.023	0.014	0.022	0.012	3.1e-05	3.8e-08	1.4e-05	5.4e-08	7.1e-05
6	TCGA	Breast Invasive Carcinoma	0.0219	0.0098	9.8e-07	0.033	0.032	0.034	NA	0.033	2.3e-07	2.9e-07	1.2e-07	NA	2.3e-07
7	TCGA	Colon Adenocarcinoma	0.0450	0.0250	1.4e-03	0.067	0.056	0.057	NA	0.062	1.0e-04	3.5e-04	3.2e-04	NA	1.9e-04
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0281	0.0145	5.2e-04	0.034	0.024	0.023	NA	0.027	9.8e-05	8.7e-04	1.1e-03	NA	4.7e-04
9	TCGA	Liver Hepatocellular Carcinoma	0.1080	0.0510	3.4e-04	0.034	0.061	0.051	NA	0.051	9.5e-03	7.6e-04	1.9e-03	NA	1.9e-03
10	TCGA	Lung Adenocarcinoma	0.0652	0.0268	7.4e-09	0.053	0.072	0.078	NA	0.063	7.3e-07	8.8e-09	1.8e-09	NA	7.3e-08
11	TCGA	Stomach Adenocarcinoma	0.0850	0.0440	1.0e-05	0.075	0.054	0.046	NA	0.060	4.2e-06	8.7e-05	2.7e-04	NA	3.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Eye problems/disorders: Glaucoma	5.0	5.9	13.9	2.9	2.5	0.0	-0.6	3.7	2.3	2.4	2.2	2.1	3.2	2.4
Systolic blood pressure, automated reading	4.8	14.0	29.4	-2.3	-4.1	-1.4	-2.4	-2.0	-4.9	-4.5	-4.2	-5.4	-2.8	-4.6
Alcohol drinker status: Never	4.7	5.6	11.0	-3.3	-2.5	-2.8	-1.0	-1.2	-2.6	-2.5	-2.4	-2.5	-1.9	-2.2
Glaucoma (self-reported)	4.2	4.9	9.1	2.7	2.2	0.8	-0.1	3.0	2.1	2.4	2.2	1.9	3.0	2.4
Qualifications: CSEs or equivalent	4.0	5.3	10.8	-3.3	-2.3	-0.9	-0.9	-1.9	-2.6	-2.6	-2.4	-3.0	-0.8	-2.7
Serious illness, injury or assault to yourself	3.8	4.5	6.9	1.1	1.7	1.6	2.6	1.8	2.4	2.3	2.3	2.2	2.6	2.3
Leg pain on walking	3.7	4.6	7.1	-2.7	-2.6	-1.8	0.9	-2.6	-2.0	-2.2	-2.1	-1.7	-2.4	-2.2
Systolic Blood Pressure	3.6	17.9	36.1	-3.1	-4.2	-1.9	-3.8	-2.9	-5.5	-5.0	-4.3	-6.0	-2.7	-5.1
Severe depression (siblings)	3.3	3.7	7.1	-1.4	-2.6	-1.4	-1.1	-0.7	-2.3	-2.5	-2.0	-1.6	-2.0	-2.7
Medication: Lisinopril	3.3	4.2	8.0	2.8	2.2	2.1	0.3	2.4	1.9	1.9	2.3	1.7	1.9	2.1
Mouth/teeth dental problems: Bleeding gums	3.1	4.0	8.2	-2.1	-2.6	0.3	1.5	-1.9	-2.2	-1.9	-1.7	-2.9	-2.1	-1.9
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	7.6	-0.3	-1.1	-2.1	-2.8	-1.8	-1.9	-1.9	-2.1	-1.6	-1.9	-1.9
Alzheimer’s Disease (in father)	2.6	2.8	5.0	0.8	1.9	-0.7	-2.0	2.2	1.9	1.7	1.2	1.8	2.2	1.3
Ever had prostate specific antigen (PSA) test	2.6	3.0	7.2	-0.7	-1.8	-1.6	1.1	-1.7	-1.8	-2.0	-1.8	-1.8	-2.7	-1.3
Diastolic blood pressure, automated reading	2.4	7.3	12.9	-2.9	-2.7	-2.1	-0.7	-0.3	-3.6	-3.3	-3.1	-3.1	-2.3	-3.4
Hypothyroidism (self reported)	2.3	5.3	17.3	-2.4	-1.4	-3.8	-4.2	-0.2	-1.7	-2.2	-2.1	1.2	-1.2	-2.2
Ovarian Cancer	2.2	2.9	5.2	1.6	2.2	1.2	2.3	-0.0	1.8	1.9	1.7	2.1	1.2	1.4
Impedance of arm (right)	2.2	10.4	18.1	1.7	3.6	1.2	3.6	1.4	3.8	3.8	3.7	4.0	2.0	4.3
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	15.7	-2.4	-1.2	-3.1	-4.0	0.5	-1.2	-1.8	-1.9	1.4	-1.4	-1.7
Hypertension (Self-reported)	2.2	6.0	14.3	-1.5	-2.6	0.1	-0.7	-1.3	-3.3	-3.2	-2.8	-3.8	-2.0	-2.9
Vascular/heart problems diagnosed by doctor	2.2	6.1	13.4	1.9	2.6	0.0	0.6	1.2	3.3	3.2	2.8	3.7	2.0	2.9
High blood pressure	2.1	6.0	14.1	-1.6	-2.6	0.1	-0.5	-1.3	-3.2	-3.1	-2.8	-3.8	-2.0	-2.9
Exposure to tobacco smoke outside home	2.1	2.8	4.2	-2.0	-1.8	-2.1	-0.6	-0.9	-1.8	-1.9	-1.7	-1.2	-1.7	-1.9
Commuting to job workplace: Walk	2.1	2.2	4.0	0.8	1.6	1.0	1.4	-0.1	1.8	1.6	2.0	2.0	1.4	1.7
Primary Biliary Cirrhosis	2.0	2.8	4.8	-1.4	-1.6	-0.2	1.2	-1.8	-1.7	-1.9	-2.2	-1.8	-1.9	-1.8
Qualifications: A levels/AS levels or equivalent	2.0	4.4	7.3	-1.8	-2.4	0.3	2.2	-2.6	-2.0	-1.7	-1.9	-2.4	-2.7	-2.0
Knee pain experienced in last month	2.0	3.1	5.7	-1.4	-1.7	-1.2	0.3	-2.4	-2.1	-2.0	-1.6	-2.2	-1.5	-1.9
Ulcerative Colitis (UC)	1.9	3.5	8.6	2.0	1.6	2.3	2.9	0.6	1.8	2.0	2.0	1.3	0.6	2.2
Hayfever, allergic rhinitis or eczema	1.9	4.1	12.0	-1.6	-2.1	1.3	0.1	-3.5	-2.3	-1.9	-1.9	-3.0	-0.0	-1.9
Impedance of arm (left)	1.8	8.3	15.9	1.2	3.2	1.0	4.0	1.6	3.4	3.4	3.2	3.4	1.0	3.8
Arm fat-free mass (right)	1.8	9.0	15.0	-3.8	-3.0	-2.9	2.7	-2.2	-3.1	-3.2	-2.2	-2.5	-3.9	-3.0
Alcohol drinker status: Previous	1.8	2.0	3.9	-1.4	-0.7	-2.0	0.1	-1.7	-1.7	-1.5	-1.6	-1.0	-1.6	-1.4
Lupus	1.7	2.6	6.2	-2.0	-2.5	-1.1	-0.1	-1.2	-1.7	-1.6	-1.8	-1.1	-1.5	-1.8
Illnesses of siblings	1.7	2.4	7.1	1.2	1.6	-1.0	0.6	0.5	2.0	2.0	1.5	2.7	0.6	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	4.4	-1.2	-1.8	0.4	0.9	-0.5	-1.6	-1.7	-1.6	-1.3	-2.1	-1.4
Eye problems/disorders: None of the above	1.7	1.9	3.9	-1.7	-1.4	-1.6	-2.0	-0.3	-1.0	-1.6	-1.2	0.0	-1.7	-1.4
Financial situation satisfaction	1.7	2.1	3.5	1.7	1.9	1.2	-0.8	1.6	1.4	1.4	1.3	1.3	1.5	1.4
Number of treatments/medications taken	1.6	2.9	5.0	-2.2	-1.1	-1.5	-1.6	-0.7	-2.1	-2.2	-2.0	-1.4	-1.3	-2.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	5.3	-2.3	-1.1	0.7	-1.7	-1.4	-1.5	-1.2	-1.4	-1.8	-0.2	-1.4
Arm predicted mass (right)	1.6	8.2	14.2	-3.8	-2.8	-2.4	2.7	-2.0	-3.0	-3.1	-2.1	-2.6	-3.6	-2.9
Average weekly red wine intake	1.6	2.4	4.7	-1.3	-2.2	-1.0	-0.3	-0.8	-1.7	-1.7	-1.7	-1.4	-1.7	-2.0
Age at First Birth	1.5	2.2	3.8	-1.3	-1.9	1.0	1.8	-1.1	-1.3	-1.2	-1.6	-1.6	-1.8	-1.1
Medication: Allopurinol	1.5	1.9	3.0	-0.9	-1.7	-1.4	-0.6	-1.5	-1.7	-1.6	-1.7	-0.9	-1.1	-1.6
Osteoporosis (self-reported)	1.5	1.9	6.5	-2.0	-0.4	-1.9	-2.5	-0.7	-0.7	-1.1	-1.5	0.2	-1.1	-1.1
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	5.6	1.0	1.0	1.9	2.4	-1.2	0.7	1.1	1.0	0.2	0.4	1.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	8.5	-0.3	-0.3	-2.0	-2.9	1.2	0.4	0.0	-0.2	2.2	0.3	-0.1
Medication: Blood pressure	1.4	2.4	5.2	-0.8	-1.4	-1.4	-1.9	0.5	-1.7	-1.9	-2.3	-1.2	-1.5	-1.7
Mineral and other dietary supplements	1.4	1.9	4.0	2.0	1.2	0.2	0.1	1.5	1.5	1.4	1.2	1.6	1.6	1.4
Risk taking	1.4	2.0	4.7	-2.2	-0.5	-2.1	-1.9	0.1	-1.0	-1.2	-1.8	0.4	-1.5	-1.1
Blood White Count	1.3	9.7	15.8	3.1	3.8	3.3	2.4	2.7	3.1	3.2	2.9	2.0	4.0	3.3
Height	1.3	24.8	146.4	-6.1	0.8	-5.5	12.1	-2.8	1.2	0.6	2.2	4.2	-4.7	1.8
Cardiovascular Disease	1.3	4.2	9.4	-0.9	-1.9	-0.1	-0.7	-2.0	-2.8	-2.6	-2.2	-3.1	-1.6	-2.3
Ever used hormone-replacement therapy (HRT)	1.3	1.7	2.5	-1.3	-1.2	-1.0	-1.5	-0.4	-1.4	-1.5	-1.6	-1.1	-1.4	-1.4
Trunk fat-free mass	1.3	7.5	14.3	-3.6	-2.5	-3.0	3.2	-2.7	-2.5	-2.6	-1.4	-1.5	-3.8	-2.2
Trunk predicted mass	1.3	7.5	14.2	-3.6	-2.5	-3.1	3.1	-2.7	-2.5	-2.7	-1.4	-1.6	-3.8	-2.2
Standing height	1.3	13.1	74.0	-4.4	-0.7	-4.1	8.6	-3.1	-0.6	-0.8	0.7	1.2	-4.6	0.2
High blood pressure (siblings)	1.3	1.9	6.6	-0.6	-1.5	0.5	-0.5	-0.6	-2.0	-1.9	-1.2	-2.6	-0.4	-1.4
Comparative height size at age 10	1.3	7.4	46.4	-2.6	-0.0	-2.8	6.8	-2.2	0.4	-0.1	0.9	1.8	-3.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	16.5	-1.0	-0.2	-0.9	4.1	-2.2	0.7	0.6	0.9	1.3	-1.5	0.7
Whole body fat-free mass	1.3	7.6	14.1	-3.5	-2.5	-2.7	3.8	-2.6	-2.5	-2.6	-1.4	-1.8	-3.7	-2.2
Whole body water mass	1.3	7.5	13.9	-3.6	-2.5	-2.6	3.7	-2.6	-2.5	-2.6	-1.4	-1.7	-3.7	-2.2
Ever taken oral contraceptive pill	1.3	1.5	5.1	0.5	1.5	0.3	-1.1	1.5	1.5	1.0	1.1	2.2	0.6	0.8
Arm fat-free mass (left)	1.3	6.4	11.6	-3.4	-2.4	-2.5	2.7	-2.0	-2.6	-2.7	-1.6	-1.8	-3.3	-2.3
Age started oral contraceptive pill	1.3	1.6	4.5	-0.4	-2.1	-0.6	-0.4	-0.6	-1.4	-1.4	-1.6	-1.3	-1.6	-1.3
Arm predicted mass (left)	1.3	6.4	11.2	-3.3	-2.3	-2.2	2.8	-2.0	-2.6	-2.7	-1.6	-1.9	-3.4	-2.3
Leg fat-free mass (left)	1.2	6.2	23.2	-3.0	-2.0	-1.7	4.8	-2.3	-1.9	-1.9	-0.9	-1.5	-3.3	-1.6
Fed-up feelings	1.2	2.2	3.5	0.6	1.9	0.4	-1.1	1.9	1.7	1.4	1.6	1.7	1.8	1.3
Supplements: Glucosamine	1.2	1.6	4.0	-1.0	-1.6	-0.2	-0.0	-2.0	-1.4	-1.3	-1.1	-1.6	-1.1	-1.2
Medication: Levothyroxine sodium	1.2	2.1	6.9	-1.2	0.1	-2.6	-2.6	1.4	-0.0	-0.4	-0.3	2.3	-0.4	-0.2
Happiness	1.2	1.5	4.7	0.3	1.0	-0.7	-1.3	1.6	1.5	1.1	0.8	2.2	1.0	0.8
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	8.2	0.5	-0.1	2.9	2.9	-1.5	0.3	0.8	0.5	-0.9	0.1	0.6
Age at last live birth	1.2	1.7	7.6	0.6	0.9	2.1	2.8	-0.9	0.8	1.1	1.4	-0.2	0.1	1.0
Eye problems/disorders: Cataract	1.2	1.4	5.1	1.2	0.8	1.9	2.3	-1.0	0.6	1.0	1.0	-0.1	0.9	0.9
Basal metabolic rate	1.2	6.9	15.4	-3.5	-2.2	-2.6	3.9	-2.2	-2.2	-2.4	-1.2	-1.5	-3.6	-2.0
Heart disease (siblings)	1.2	1.5	3.5	-1.9	-1.2	0.0	-0.6	-0.4	-1.3	-1.4	-1.4	-1.7	-0.8	-1.2
Impedance of whole body	1.2	6.2	11.7	1.2	3.2	0.5	1.7	2.1	3.0	3.0	2.6	3.4	1.3	3.3
Bipolar Disorder (2018)	1.1	1.7	3.2	-1.8	-1.3	0.8	0.4	0.3	-1.2	-1.1	-1.6	-1.7	-1.6	-1.4
Worry (Nagel 2018)	1.1	2.2	3.5	-0.9	-1.7	-1.2	-1.3	-1.4	-1.6	-1.6	-1.7	-1.9	-1.2	-1.5
Blood Red Count	1.1	11.0	15.4	-2.9	-3.9	-2.6	-1.9	-3.4	-3.9	-3.7	-3.8	-3.9	-1.3	-3.9
Allergy or Eczema	1.1	2.9	8.5	-1.7	-1.7	0.9	-0.4	-2.9	-1.9	-1.6	-1.8	-2.3	0.2	-1.7
High blood pressure (mother)	1.1	1.6	4.0	-0.7	-1.1	-0.9	0.8	-2.0	-1.6	-1.3	-0.9	-1.2	-1.4	-1.2
Leg predicted mass (left)	1.1	5.9	23.6	-2.9	-1.8	-1.6	4.9	-2.3	-1.8	-1.8	-0.8	-1.4	-3.2	-1.5
Forced vital capacity (FVC)	1.1	4.2	16.1	-3.4	0.1	-2.1	4.0	-3.0	-0.5	-0.9	0.2	0.1	-2.0	-0.3
Hair/balding pattern: Pattern 3	1.1	1.7	5.0	-0.4	-1.0	-1.1	-1.4	-2.2	-1.4	-1.4	-1.3	-1.5	-0.0	-1.1
Pulse wave Arterial Stiffness index	1.1	1.2	3.1	-0.2	-0.9	-0.3	-0.4	-0.7	-1.4	-1.2	-1.6	-1.4	-1.0	-1.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.3	-0.8	-1.1	-1.5	-0.3	-0.2	-1.5	-1.4	-1.2	-1.1	-0.7	-1.4
Medication: Ibuprofen	1.1	1.3	3.5	-1.9	-1.2	-0.7	-1.3	0.3	-0.8	-0.9	-1.5	-0.3	-1.0	-1.4
Number of self-reported non-cancer illnesses	1.1	1.9	4.0	-2.0	-1.1	-0.4	-1.0	-0.3	-1.7	-1.9	-1.9	-1.3	-0.7	-1.6
Basal cell carcinoma (self-reported)	1.1	1.3	7.3	1.2	0.7	2.7	1.4	0.8	0.6	0.6	0.6	0.1	0.5	0.9
Triglycerides	1.0	1.6	2.7	1.3	1.3	1.4	0.6	1.4	1.1	1.4	1.6	0.4	1.6	1.3
Hearing difficulty/problems with background noise	1.0	1.5	4.0	0.4	1.5	0.4	-0.5	2.0	1.4	1.2	1.3	1.2	1.3	1.3
Allergy	1.0	2.4	6.0	1.4	1.2	-1.9	-0.8	2.4	1.6	1.3	1.1	2.3	-0.1	1.2
Age at first live birth	1.0	1.7	5.1	1.3	1.0	2.3	1.9	-0.1	0.9	1.2	1.3	0.1	1.5	1.2
Pulse wave peak to peak time	1.0	1.2	3.0	0.0	0.9	-0.1	1.0	0.4	1.3	1.1	1.6	1.4	0.5	1.7
Leg fat-free mass (right)	1.0	5.6	21.0	-2.9	-2.0	-2.0	4.6	-2.2	-1.7	-1.8	-0.7	-1.2	-3.0	-1.4
Leg predicted mass (right)	1.0	5.3	21.3	-2.8	-1.9	-1.9	4.6	-2.2	-1.6	-1.6	-0.6	-1.1	-3.0	-1.4
Medication: Paracetamol	1.0	1.5	2.5	-1.5	-0.9	-0.5	-0.4	-1.5	-1.2	-1.3	-1.4	-1.2	-1.6	-1.4
Bipolar Disorder or Schizophrenia	0.9	2.2	8.0	-1.2	-1.0	0.2	2.8	-0.6	-1.2	-1.2	-1.6	-2.0	-1.6	-1.4
Major Depression (MDD)	0.9	1.1	2.8	-0.7	-1.1	-0.5	1.3	0.0	-1.4	-1.7	-0.8	-1.2	-0.6	-1.2
Bipolar Disorder (2011)	0.9	0.9	1.5	-1.2	-1.1	-0.1	0.1	-0.6	-1.0	-1.1	-1.2	-0.8	-1.2	-1.1
Coronary Artery Disease (CAD)	0.9	1.1	4.3	1.0	1.0	2.1	1.1	1.4	0.5	0.5	0.9	-0.1	0.7	1.0
Blood Platelet Count	0.9	10.7	19.2	1.9	3.6	2.8	1.0	2.5	4.0	4.4	3.5	3.3	3.7	3.7
Lung FEV1/FVC ratio	0.9	4.5	10.3	3.2	1.2	2.4	0.1	2.3	2.4	2.4	2.0	2.0	1.8	2.0
Average weekly spirits intake	0.9	1.1	3.9	0.1	1.2	-0.1	-1.3	1.6	1.1	0.8	0.5	2.0	0.0	0.8
Angina	0.9	1.2	4.0	0.4	0.7	-0.1	-1.7	0.2	0.8	0.7	0.7	2.0	1.9	0.5
Stomach or abdominal pain in last month	0.9	1.2	3.6	0.2	1.8	0.7	-0.5	0.7	0.9	1.0	1.2	0.6	1.9	1.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	4.6	0.3	-1.0	-2.1	-0.8	-0.0	-1.1	-1.1	-0.9	-0.8	-0.5	-1.0
Weight	0.9	4.3	18.4	-2.6	-1.5	-2.1	4.3	-1.0	-1.5	-1.6	-0.7	-0.8	-2.7	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.5	-1.9	-0.9	-0.7	-0.9	0.6	-0.8	-0.9	-1.3	-0.6	-1.1	-1.3
Tense / ‘highly strung’	0.9	1.5	3.2	-0.5	-1.6	-0.7	-1.6	-0.2	-1.3	-1.4	-1.2	-1.8	-0.8	-1.4
Birth weight of first child	0.9	1.7	4.2	-1.0	-2.0	-0.6	1.2	-1.8	-1.2	-1.1	-1.0	-0.1	-2.0	-0.9
Forced vital capacity (FVC), Best measure	0.9	3.4	13.5	-3.3	0.2	-2.2	3.7	-2.4	-0.1	-0.5	0.3	0.4	-1.4	-0.0
Suffer from ‘nerves’	0.9	1.4	1.8	-1.1	-1.3	-1.2	-1.0	-0.9	-1.2	-1.3	-1.2	-1.3	-1.2	-1.1
Commuting to job workplace: Cycle	0.9	1.1	3.7	-1.1	-1.2	-1.0	0.5	-1.1	-0.8	-0.6	-1.0	-0.8	-1.9	-0.8
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.5	0.4	-1.7	-0.8	-0.2	-2.0	-1.6	-1.3	-1.1	-2.3	-1.0	-1.1
Rheumatoid Arthritis	0.8	1.1	3.8	0.5	1.3	0.5	-0.0	1.9	1.0	0.8	1.0	0.3	1.3	1.3
Ulcerative Colitis	0.8	1.2	8.1	0.2	-0.6	1.6	2.8	-1.1	-0.2	0.1	-0.1	-0.7	-0.8	0.3
Diabetes (mother)	0.8	1.0	3.5	-1.0	-0.4	-1.9	-0.8	0.8	-0.9	-1.1	-1.0	0.3	-0.5	-1.3
Townsend deprivation index at recruitment	0.8	1.1	3.3	-0.5	-0.6	-0.4	-1.1	-0.7	-1.1	-1.3	-0.9	-0.9	-1.8	-1.1
Taking other prescription medications	0.8	1.3	5.8	-2.4	-0.3	-1.3	-1.4	-0.4	-0.9	-1.1	-1.1	0.1	-0.1	-1.1
Financial difficulties in last 2 years	0.8	1.1	2.4	-0.1	1.1	0.9	1.5	0.8	1.1	1.1	1.2	1.4	0.4	1.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.0	-0.8	-1.2	0.6	0.5	0.3	-1.3	-1.2	-1.4	-0.7	0.1	-1.4
Long-standing illness, disability or infirmity	0.8	1.3	2.6	-1.6	-0.9	-1.4	1.0	-0.7	-1.1	-1.2	-1.3	-0.1	-1.1	-1.1
Irritability	0.8	1.4	6.9	-0.4	-0.7	-0.5	-2.6	-0.2	-1.1	-1.2	-1.2	-1.2	-1.0	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.1	0.9	1.1	0.6	1.1	0.5	1.2	1.0	1.0	1.2	0.7	1.4
Schizophrenia (2018)	0.7	1.4	11.0	-0.0	-0.2	-0.3	3.3	-1.0	-0.6	-0.7	-0.8	-1.2	-0.7	-0.7
Crohns Disease (2012)	0.7	1.1	5.6	-0.2	0.6	1.9	2.4	1.0	0.3	0.4	0.8	-0.0	0.2	0.7
Neuroticism (2016)	0.7	1.0	5.1	-1.4	-0.3	-1.4	-2.2	-0.1	-0.7	-0.5	-0.5	-0.3	-0.1	-0.8
Medication for hormone replacement therapy	0.7	0.8	2.3	0.1	1.0	0.2	-0.9	-0.3	0.8	0.9	1.0	1.1	1.5	0.9
Current tobacco smoking	0.7	1.1	2.4	0.7	1.4	-0.0	-0.2	1.5	1.1	1.0	1.0	1.5	1.1	0.9
Medication: Atenolol	0.7	0.9	1.8	0.2	-1.0	-0.2	-0.6	-0.6	-1.3	-1.3	-1.2	-1.4	-0.6	-1.1
Impedance of leg (left)	0.7	3.4	7.3	0.8	2.4	-0.4	-1.5	2.3	2.1	1.9	1.4	2.7	1.4	2.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	10.4	-2.5	0.2	-1.5	3.2	-2.3	-0.0	-0.3	0.6	0.5	-1.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	2.0	0.2	0.6	1.1	0.8	-0.0	1.4	1.3	0.9	1.1	0.9	0.9
Mouth/teeth dental problems: Dentures	0.7	1.2	2.2	0.8	1.5	-0.4	0.4	1.2	1.0	1.2	1.4	1.4	1.0	1.2
Blood clot in the leg (DVT)	0.7	0.9	1.8	1.0	1.1	0.6	1.1	0.6	1.0	0.9	0.9	0.9	0.5	1.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.9	0.3	0.7	0.8	1.7	-0.2	1.2	1.4	1.7	0.4	1.2	1.1
Comparative body size at age 10	0.7	1.9	4.9	2.2	1.3	1.1	-1.6	0.8	1.3	1.2	1.5	1.1	1.5	1.2
Angina (self-reported)	0.7	0.9	3.1	0.3	0.5	-0.0	-1.5	0.1	0.7	0.6	0.6	1.7	1.8	0.4
Had major operations	0.7	0.9	7.8	-0.3	0.1	0.6	2.8	0.0	0.4	0.5	0.2	-0.6	-0.2	0.7
Mood swings	0.7	1.3	4.5	-1.3	-0.4	-2.0	-2.1	1.1	-0.5	-1.0	-0.7	-0.1	-0.5	-1.0
Diabetes diagnosed by doctor	0.7	1.2	2.8	-1.1	-0.6	-0.3	-0.4	-0.1	-1.6	-1.5	-1.7	-1.0	-0.7	-1.3
Qualifications: nursing, teaching	0.7	1.1	2.8	1.1	-1.4	0.3	1.7	-0.9	-0.8	-0.6	-0.4	-1.4	-1.4	-0.4
Guilty feelings	0.7	1.0	2.5	0.3	0.8	-1.6	-0.8	1.2	1.0	0.8	0.9	1.4	1.0	0.7
Wears glasses or contact lenses	0.7	0.8	2.8	-0.7	-1.0	-0.9	0.1	-0.5	-0.6	-0.9	-1.1	-0.2	-1.7	-0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.0	-0.7	0.3	-1.7	-1.4	0.1	0.5	0.5	0.1	1.5	0.4	0.6
Medication: Blood pressure	0.7	1.4	5.3	-0.4	-0.8	0.3	1.7	-1.0	-1.6	-1.2	-0.6	-2.3	-0.4	-1.0
Pain experienced in last month	0.7	1.2	2.7	1.6	0.8	-0.1	-1.1	1.5	1.3	1.1	0.5	1.2	0.6	1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.1	1.4	1.0	-0.4	1.4	0.7	0.6	0.7	1.2	0.9	0.4	0.9
Irritable Bowel Disease (IBD)	0.6	1.4	3.2	1.2	1.3	1.4	1.8	1.1	0.9	1.1	1.2	0.7	0.2	1.5
Schizophrenia (2014)	0.6	1.3	8.2	-0.7	-0.5	0.2	2.9	-0.9	-0.7	-0.8	-0.7	-1.4	-0.6	-0.8
Chronotype (morning person)	0.6	1.4	3.9	-0.4	-1.0	-1.4	-0.3	1.4	-1.6	-1.4	-1.2	-2.0	0.0	-0.5
Sensitivity / hurt feelings	0.6	1.0	7.4	-0.6	0.6	-1.2	-2.7	0.8	-0.0	-0.3	-0.1	0.3	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.1	-1.0	0.6	-0.6	1.0	0.5	0.7	0.5	0.2	1.8	-0.1	0.5
Trunk fat mass	0.6	2.4	18.4	-1.6	-0.1	-1.0	4.3	0.5	-0.5	-0.6	-0.2	-0.1	-1.9	-0.2
Waist circumference	0.6	2.1	4.3	-2.0	-1.4	-1.6	2.1	-0.2	-1.4	-1.5	-1.3	-1.1	-1.2	-1.3
Past tobacco smoking	0.6	1.2	3.3	0.7	0.4	1.4	1.8	0.6	0.6	0.9	1.1	-0.3	1.8	1.0
Alcohol usually taken with meals	0.6	0.9	2.4	-0.8	-1.4	-1.5	-0.7	-0.4	-1.0	-1.1	-0.7	-0.7	-0.7	-0.8
Had other major operations	0.6	0.7	2.3	-1.5	-0.9	-0.7	1.2	-0.4	-0.4	-0.4	-0.8	-0.4	-0.9	-0.7
Heart attack	0.6	0.8	1.8	1.3	1.1	-0.4	1.3	0.6	0.6	0.7	1.2	1.0	0.4	0.8
Hip circumference	0.6	2.5	12.1	-1.9	-1.3	-1.2	3.5	-0.9	-1.2	-1.2	-0.6	-0.9	-1.7	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	10.1	-2.2	0.3	-1.4	3.2	-1.6	0.4	0.1	0.8	0.6	-0.8	0.4
Exposure to tobacco smoke at home	0.6	0.6	1.4	-0.9	-0.7	0.1	0.4	-0.8	-1.2	-1.0	-0.6	-1.0	-1.0	-0.5
Medication: Paracetamol	0.6	0.9	1.7	-1.3	-0.4	-0.1	-0.5	-1.0	-1.0	-1.0	-1.1	-1.0	-1.2	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	1.0	1.1	0.0	0.4	1.3	0.9	0.7	0.9	1.0	0.9	0.7
Number of children fathered	0.6	0.7	3.1	0.4	-0.7	0.4	1.8	-1.1	-0.3	-0.3	-0.0	-1.1	-0.8	-0.2
Shortness of breath walking on level ground	0.6	0.7	3.0	-0.8	-0.6	-1.0	-1.7	0.0	-0.8	-0.9	-0.6	-0.2	0.1	-1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	2.0	1.1	0.6	0.6	0.6	0.1	1.1	1.3	1.2	0.6	1.4	1.3
Illnesses of father: Heart disease	0.6	0.9	3.2	1.5	1.2	1.8	-0.3	0.1	0.4	0.4	1.1	0.1	0.8	0.8
Number of operations (self-reported)	0.6	0.8	2.8	-1.7	-0.5	-0.4	1.6	-0.7	-0.4	-0.3	-0.5	-0.6	-1.4	-0.3
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.5	-0.5	-1.7	-0.3	0.4	-1.9	-1.4	-1.4	-1.3	-1.6	-1.1	-1.2
Neuroticism (Nagel 2018)	0.5	1.2	6.3	-1.0	-0.5	-1.8	-2.5	-0.3	-0.5	-0.6	-0.8	-0.3	-0.1	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	1.3	0.9	1.1	-0.6	-0.7	0.9	0.9	0.7	1.0	1.1	0.9	0.6
Fasting Glucose	0.5	0.6	1.7	0.8	1.2	-0.3	-0.5	1.3	0.8	0.5	0.8	0.2	0.7	0.5
LDL Cholesterol	0.5	0.7	1.7	1.3	0.7	1.1	1.0	1.0	0.6	0.5	0.6	0.5	1.0	0.7
Lung FVC	0.5	2.8	13.5	-2.6	0.0	-1.7	0.5	-3.7	-0.7	-1.0	-1.1	-0.6	-1.6	-1.0
Ever had hysterectomy (womb removed)	0.5	0.6	2.6	-0.3	0.5	-0.8	0.4	1.6	0.8	0.9	0.1	0.6	0.6	0.8
Average weekly fortified wine intake	0.5	0.6	2.0	-1.4	-0.8	-1.2	-0.2	-0.6	-0.3	-0.4	-0.9	-0.2	-0.5	-0.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	-0.8	-1.0	-0.7	-0.4	-0.6	-0.6	-0.5	-1.0	-0.5	-0.9	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	3.5	-0.3	0.5	-0.6	-1.9	1.1	0.5	0.3	-0.1	0.5	-0.3	-0.4
Sitting height	0.5	3.8	23.7	-2.3	0.1	-1.6	4.9	-1.9	-0.2	-0.2	0.8	1.0	-2.0	0.5
Chronic bronchitis/emphysema (father)	0.5	0.6	2.3	-0.1	-0.5	-1.0	-1.4	1.5	-0.1	-0.2	0.2	0.6	0.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.8	-1.0	-0.6	-0.4	-1.0	-0.4	-0.8	-1.0	-0.9	-1.3	-0.1	-1.1
Qualifications: None of the above	0.5	1.0	3.1	0.7	1.7	-0.4	-0.7	1.1	0.9	0.5	0.9	1.8	0.6	0.7
Pain all over the body in last month	0.5	0.5	3.4	-0.5	-0.1	0.4	1.9	-0.5	-0.4	-0.2	0.2	-0.8	-0.6	-0.1
Diabetes (self-reported)	0.5	0.8	1.8	-1.1	-0.3	-0.1	-0.1	-0.3	-1.3	-1.3	-1.3	-0.9	-0.4	-0.9
Medication: Ramipril	0.5	0.6	2.0	-0.9	-0.3	-1.4	-0.1	0.0	-0.8	-1.0	-0.8	-0.8	-0.6	-0.6
Number of live births	0.5	0.7	2.3	-0.4	0.1	0.8	1.5	-1.5	-0.5	-0.3	0.1	-1.1	-1.0	-0.2
Medication: Lansoprazole	0.5	0.5	1.8	0.1	1.3	0.7	0.4	0.3	0.7	0.6	0.9	1.1	0.0	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	3.7	-0.7	-0.2	-1.9	-1.2	0.6	-0.1	-0.5	-0.7	0.8	0.0	-0.6
Medication: Amlodipine	0.5	0.7	3.2	0.1	-0.9	-1.8	0.3	0.8	-0.8	-0.8	-0.4	-0.5	-1.1	-0.5
Emphysema/chronic bronchitis	0.5	0.6	1.3	0.4	0.9	0.0	-0.7	1.0	0.9	0.7	0.6	1.0	1.1	0.4
Medication: Seretide 50 evohaler	0.5	0.6	1.8	-1.1	-0.1	-0.7	0.6	-1.2	0.6	0.4	0.1	1.4	0.5	0.2
Heart disease (mother)	0.5	0.7	1.3	-0.3	-0.9	0.3	-0.8	-0.2	-1.0	-1.1	-0.9	-0.6	-0.9	-1.0
Loneliness, isolation	0.5	0.7	3.8	-1.0	0.6	0.9	-0.5	1.9	0.7	0.2	0.2	0.6	1.0	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.9	0.4	0.8	0.7	0.9	1.7	0.5	0.8	0.9	-0.1	0.2	0.5
Osteoarthritis (self-reported)	0.5	0.7	1.1	-1.0	-1.0	-1.0	0.3	-0.7	-0.8	-0.9	-1.0	-0.5	-0.6	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-0.9	-0.3	-1.1	1.0	-0.9	-0.5	-0.6	-1.0	-0.3	-0.9	-0.7
Smoking status: Current	0.5	0.8	2.7	0.2	1.0	-0.5	-0.8	1.6	0.9	0.7	0.5	1.4	0.8	0.5
Hearing aid user	0.5	0.6	1.7	0.7	0.6	-0.5	0.0	1.3	0.7	0.7	0.8	0.2	1.2	0.6
Ever smoked	0.5	0.9	3.0	-0.8	-0.3	-0.9	-1.5	-0.4	-0.6	-0.8	-0.9	0.0	-1.7	-1.1
Depression (Nagel 2018)	0.4	0.7	1.4	-1.2	-0.0	0.6	-1.0	0.3	-0.7	-1.0	-0.6	-1.2	0.5	-1.0
HbA1C	0.4	0.5	1.7	1.0	0.5	-0.2	1.3	1.2	0.1	-0.1	0.8	-0.4	0.3	0.3
Smoking Status	0.4	1.0	3.6	-0.5	0.1	-1.6	-1.9	0.6	-0.3	-0.6	-0.8	1.0	-1.2	-0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.8	0.2	1.2	1.4	-0.3	0.8	0.9	0.4	0.9	0.3	0.8	0.5
Hearing difficulty/problems: Yes	0.4	0.6	1.6	0.2	1.1	1.3	0.1	1.1	0.8	0.4	0.6	0.5	0.5	0.9
Supplements: Zinc	0.4	0.4	1.7	-1.1	-0.8	-1.3	-0.1	0.2	-0.3	-0.2	-0.3	-0.2	-0.4	-0.5
Medication: Metformin	0.4	0.5	1.1	-0.8	-0.2	-0.0	-1.0	-0.5	-0.8	-1.0	-1.0	-0.5	0.2	-0.6
Diabetes (father)	0.4	0.5	1.3	-0.6	-0.6	-0.5	0.6	0.5	-0.8	-0.7	-1.1	-0.9	-0.8	-0.7
Pack years adult smoking proportion	0.4	0.6	2.4	0.2	0.9	-0.0	0.6	1.6	0.7	0.7	0.6	0.9	1.0	0.4
Impedance of leg (right)	0.4	2.1	5.3	0.5	2.3	-0.0	-1.0	1.8	1.6	1.6	1.0	2.0	0.8	1.7
Trunk fat percentage	0.4	1.7	14.8	-0.7	0.6	-0.1	3.9	1.4	0.2	0.1	0.3	0.5	-1.0	0.5
Maternal smoking around birth	0.4	0.5	1.5	-0.8	-0.5	0.5	0.7	0.7	-0.8	-0.7	-0.2	-0.7	-1.2	-0.6
Nervous feelings	0.4	0.8	1.4	-0.3	-0.9	-0.5	-0.8	-0.3	-1.1	-1.2	-0.9	-1.2	-1.1	-0.8
Pulse rate	0.4	0.7	1.3	0.2	0.6	0.9	0.2	0.9	1.0	1.2	0.6	0.9	1.1	1.0
Depression (self-reported)	0.4	0.5	2.6	-0.1	0.7	-0.1	-1.3	1.6	0.1	-0.1	0.0	-0.1	1.0	-0.1
Breastfed as a baby	0.4	0.4	2.5	1.6	-0.5	0.5	1.0	-0.6	-0.4	-0.3	0.1	-0.4	-0.1	-0.2
Loud music exposure frequency	0.4	0.4	2.4	0.1	0.3	0.1	-0.7	-0.1	0.6	0.6	0.5	0.8	1.6	0.5
Headache pain in last month	0.4	0.7	1.4	-1.2	-0.4	0.7	1.1	-0.0	-0.7	-0.7	-1.0	-0.8	-0.9	-0.9
Gout (self-reported)	0.4	0.6	1.3	-0.4	-0.7	-0.0	0.4	-0.2	-1.1	-1.0	-1.1	-1.0	-0.6	-0.8
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.7	0.1	-0.1	1.6	0.9	0.6	0.1	0.3	0.8	0.2	0.3	0.4
Health satisfaction	0.4	0.6	3.7	-1.1	-0.2	-0.3	-1.9	0.0	0.2	0.3	-0.1	0.9	0.1	0.2
Medication: Omeprazole	0.4	0.4	1.3	-1.1	-0.2	-0.5	-0.9	-0.3	-0.8	-0.9	-0.3	-0.2	-0.5	-0.6
Whole body fat mass	0.4	1.7	11.1	-1.5	-0.3	-0.9	3.3	0.5	-0.7	-0.8	-0.4	-0.3	-1.5	-0.5
Number of full sisters	0.4	0.5	1.4	0.5	0.7	0.3	0.4	1.1	0.4	0.5	1.0	-0.1	1.2	0.7
Friendships satisfaction	0.4	0.5	1.9	-0.8	-0.4	-0.6	-1.4	-0.5	-0.4	-0.8	-0.5	-0.7	0.3	-0.6
Asthma (self-reported)	0.4	0.8	3.6	-1.9	-0.1	-0.3	-0.5	-0.2	-1.0	-1.1	-0.9	-0.5	-0.1	-1.0
Medication: Gliclazide	0.4	0.4	2.0	-0.0	-0.3	-1.4	-0.5	0.8	-0.2	-0.6	-0.6	0.6	-0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	4.5	-0.1	-0.2	-2.1	0.7	-0.3	-0.1	-0.2	0.1	0.6	0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	-1.0	-0.2	1.0	1.0	-1.1	-0.4	-0.2	-0.1	-0.7	-0.8	-0.2
High cholesterol (Self-reported)	0.4	0.7	2.9	1.7	0.9	0.8	-0.5	0.5	0.5	0.6	0.6	0.8	-0.1	0.9
Ever depressed for a whole week	0.4	0.5	3.4	0.4	-0.6	-1.9	-0.5	0.8	-0.2	-0.2	-0.2	0.1	-0.1	-0.4
Unable to work because of sickness or disability	0.4	0.6	2.2	-0.7	-0.4	-0.4	0.6	-1.5	-0.7	-1.0	-0.8	-0.2	-0.3	-0.8
Supplements: Calcium	0.4	0.4	0.9	-0.8	-0.9	-0.0	0.2	-0.6	-0.7	-0.9	-0.4	-0.4	-0.5	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.3	1.6	0.4	-0.4	-0.9	0.3	-1.3	-0.5	-0.3	-0.0	-0.1	0.7	-0.3
Prostate Cancer	0.3	0.4	1.7	-0.6	0.1	-1.1	-1.3	0.3	-0.0	-0.4	-0.1	0.9	-0.3	-0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.7	-0.2	-0.1	1.1	1.3	0.5	0.0	0.1	0.3	-0.2	-0.3	0.5
Relative age of first facial hair	0.3	0.7	2.4	-0.4	-0.8	0.7	0.2	0.1	-0.8	-0.5	-0.9	-1.5	-1.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	2.1	-0.7	0.0	-0.5	-1.4	0.9	-0.2	-0.6	-0.5	-0.5	0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	4.4	-0.2	-0.1	0.2	2.1	0.5	0.7	0.7	-0.2	0.7	-0.9	0.3
Fluid intelligence score	0.3	0.7	1.5	0.0	-0.7	-1.2	-0.6	-0.8	-0.9	-0.9	-0.7	-0.9	-1.2	-0.8
Time employed in main current job	0.3	0.3	2.2	1.0	-0.2	-1.5	-0.2	0.6	-0.1	0.0	0.2	0.4	-0.1	0.3
Alcohol intake versus 10 years previously	0.3	0.5	1.8	-0.9	-0.4	0.3	0.8	-1.3	-0.5	-0.5	-0.4	-0.5	-0.7	-0.4
Father’s age at death	0.3	0.4	2.0	1.4	-0.8	-0.3	1.0	0.4	-0.0	-0.0	0.1	-0.1	-0.1	0.2
Falls in the last year	0.3	0.3	1.2	-1.1	-0.1	0.6	0.7	-0.4	-0.3	-0.2	0.2	-0.5	-1.1	-0.2
Prospective memory result	0.3	0.4	1.1	-0.1	-1.1	-0.0	0.1	0.7	-0.6	-0.5	-0.6	-1.0	0.3	-0.7
Arm fat mass (right)	0.3	1.1	5.9	-1.4	-0.5	-0.6	2.4	0.4	-0.8	-0.9	-0.4	-0.5	-1.2	-0.7
Peak expiratory flow (PEF)	0.3	0.7	3.5	-1.9	-0.5	-1.0	0.8	-1.1	-0.2	-0.5	0.1	0.2	-0.6	-0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.0	-0.2	0.3	0.1	-1.1	0.6	-0.3	-0.5	0.2	0.0	1.4	-0.4
Body fat percentage	0.3	1.0	7.8	-0.5	0.6	-0.0	2.8	1.5	0.1	0.1	0.1	0.3	-0.5	0.3
Qualifications: College or University degree	0.3	1.0	3.3	-0.3	-1.8	0.3	1.3	-1.0	-0.7	-0.8	-1.0	-0.7	-1.3	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.9	-0.1	0.2	0.7	-1.4	0.3	0.6	0.5	0.2	0.5	0.4	0.2
Leg fat mass (right)	0.3	1.1	3.9	-1.3	-0.4	-0.8	2.0	0.6	-1.0	-1.0	-0.8	-0.7	-1.1	-0.8
Alcohol intake frequency.	0.3	0.6	2.4	-0.8	-0.4	-0.7	1.6	-0.4	-0.9	-1.0	-0.4	-1.0	0.2	-0.6
Chest pain or discomfort	0.3	0.5	1.5	-1.1	-0.5	-0.2	0.2	-1.2	-0.5	-0.7	-0.5	-0.2	-0.5	-0.9
Family relationship satisfaction	0.3	0.4	1.7	-0.7	-0.4	0.1	-0.1	0.7	-0.4	-0.4	-0.6	-0.3	-1.3	-0.5
Supplements: Vitamin C	0.3	0.3	1.3	0.1	0.8	0.2	1.1	0.4	0.4	0.7	0.6	0.5	0.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.8	0.5	-0.2	0.7	-0.5	0.5	0.7	0.6	0.7	-0.2	0.7
Illnesses of siblings: Diabetes	0.3	0.3	1.4	0.9	0.3	1.2	-1.0	0.4	0.2	-0.1	-0.1	0.2	0.0	0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	-0.9	0.3	0.8	1.0	0.9	0.5	0.7	0.3	0.0	0.3	0.4
Back pain experienced in last month	0.3	0.4	1.6	-0.8	-0.6	-0.2	-0.4	-0.4	-0.8	-0.6	-0.3	-0.6	1.2	-0.7
Breast cancer (self-reported)	0.3	0.4	1.7	-0.7	-0.8	-1.3	0.6	-0.6	-0.2	0.1	-0.1	-0.3	-0.5	0.0
Arm fat mass (left)	0.3	1.3	7.5	-1.5	-0.5	-0.6	2.7	0.5	-0.7	-0.7	-0.3	-0.4	-1.2	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.4	0.1	0.7	0.1	-0.8	0.7	0.3	0.5	0.7	0.3	1.2	0.8
Commuting to job workplace: Public transport	0.3	0.3	0.9	0.6	0.5	1.0	-0.1	0.6	0.5	0.5	0.7	-0.1	0.0	0.7
Medication: Bendroflumethiazide	0.3	0.5	2.1	-0.7	-0.3	0.4	-0.3	-0.5	-0.9	-1.0	-0.6	-1.4	-0.1	-0.7
Depressed Affect (Nagel 2018)	0.2	0.5	1.8	-1.0	0.5	-0.7	-1.3	1.0	0.0	-0.2	-0.1	0.3	0.6	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.8	0.3	-0.0	0.5	-0.3	0.4	0.3	0.7	0.7	-0.2	0.3
Crohns Disease (2017)	0.2	0.4	2.1	0.1	1.0	0.8	-0.0	1.4	0.3	0.2	0.5	0.3	0.4	0.6
Reaction Time	0.2	0.3	1.0	-1.0	0.0	-0.1	0.4	0.6	0.7	0.5	0.5	0.4	0.6	0.5
Breast Cancer	0.2	0.4	1.1	0.5	0.5	-0.7	-0.2	0.3	0.6	0.5	0.9	1.1	0.4	0.7
Mean Putamen Volume	0.2	0.3	2.2	-0.1	0.3	-0.5	-1.5	0.0	-0.1	0.0	0.1	-0.3	0.6	0.1
Respiratory disease	0.2	0.5	2.9	-1.7	0.3	-0.1	-0.2	0.2	-0.8	-1.0	-0.5	-0.5	-0.2	-0.6
Neuroticism	0.2	0.5	3.5	-0.3	-0.2	-1.2	-1.9	0.2	-0.2	-0.4	-0.0	-0.0	0.2	-0.6
Hand grip strength (left)	0.2	0.5	3.9	0.4	-0.1	-0.5	2.0	-0.2	0.4	0.5	0.6	0.5	-0.3	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.8	-0.7	-0.1	0.2	0.2	-1.4	0.1	-0.1	-0.2	0.7	-0.4	-0.1
Relative age voice broke	0.2	0.4	1.4	0.6	0.6	0.7	1.0	1.2	0.1	0.1	-0.0	-0.7	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.8	0.0	-1.0	-0.1	1.7	0.4	-0.1	0.0	-0.7	-0.0	-0.8	-0.4
Body mass index (BMI)	0.2	1.0	1.9	-0.7	-1.2	-0.2	0.4	0.5	-1.3	-1.3	-1.1	-1.3	-0.6	-1.4
Neuroticism score	0.2	0.5	4.0	-0.2	-0.1	-0.8	-2.0	0.6	0.0	-0.4	-0.1	-0.1	0.3	-0.4
Arm fat percentage (right)	0.2	0.7	4.7	-0.2	0.7	0.5	2.2	1.2	0.3	0.3	0.5	0.4	0.0	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.8	-0.8	0.0	0.9	0.8	0.8	-0.1	-0.1	0.1	0.1	0.4	-0.4
Noisy workplace	0.2	0.2	0.7	-0.7	-0.2	0.7	-0.6	-0.9	-0.4	-0.3	0.0	-0.2	0.4	-0.2
Asthma	0.2	0.5	2.9	-1.7	0.2	-0.1	-0.2	0.2	-0.7	-0.8	-0.6	-0.1	0.0	-0.8
Lung cancer (father)	0.2	0.2	0.5	-0.3	0.3	0.6	-0.0	0.7	0.5	0.2	0.5	0.7	0.2	0.4
Illnesses of mother	0.2	0.3	1.2	0.3	0.4	-0.4	0.0	0.6	0.5	0.7	-0.0	-0.4	1.1	0.5
Length of working week for main job	0.2	0.2	0.8	-0.4	-0.2	0.9	0.4	-0.0	-0.0	-0.3	0.1	-0.1	-0.9	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	0.8	0.8	1.2	0.9	0.0	0.8	0.6	0.8	-0.2	0.0	0.6
Number of full brothers	0.2	0.2	1.0	-0.2	0.6	1.0	-0.4	-0.5	0.2	0.4	0.3	0.4	-0.3	0.3
Worry too long after embarrassment	0.2	0.4	2.0	0.4	-0.5	-1.2	-1.4	-0.4	0.3	0.1	-0.1	0.4	0.0	-0.2
Neck or shoulder pain in last month	0.2	0.2	0.9	0.9	0.3	0.7	0.4	-0.3	-0.3	-0.4	-0.1	-0.1	0.6	-0.0
Migraine (self-reported)	0.2	0.3	1.2	-1.1	-0.5	-0.7	0.7	0.4	-0.3	-0.4	-0.3	-0.2	0.4	-0.3
Mean time to correctly identify matches	0.2	0.4	1.0	-0.1	0.5	0.5	0.4	1.0	0.7	0.5	0.7	0.4	0.6	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	-0.1	0.2	0.6	-0.0	0.8	-0.1	-0.2	-0.2	-0.8	0.4	-0.1
Medication: Aspirin	0.2	0.2	0.9	-0.2	0.2	-1.0	-0.8	0.7	-0.3	-0.3	-0.1	0.1	-0.1	-0.4
Smoking status: Previous	0.2	0.3	1.5	-0.3	-0.3	-0.4	-0.4	-0.9	-0.4	-0.6	-0.5	-0.1	-1.2	-0.4
Arm fat percentage (left)	0.2	0.8	5.7	-0.4	0.5	0.4	2.4	1.4	0.2	0.2	0.3	0.2	-0.2	0.3
Ever had bowel cancer screening	0.2	0.3	0.7	0.2	0.2	0.8	0.6	0.5	0.3	0.3	0.5	0.9	0.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.0	0.3	0.0	-1.0	-0.8	-0.4	0.3	-0.2	0.1	0.7	-0.1	-0.2
Medication for cholesterol	0.2	0.3	2.1	0.7	-0.2	-0.6	-0.3	1.4	0.4	0.2	-0.1	0.5	-0.2	0.1
Medication: Aspirin	0.2	0.3	0.8	-0.1	0.0	-0.9	-0.7	0.5	-0.6	-0.5	-0.4	-0.0	-0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.3	-0.5	1.1	0.7	0.6	-0.8	0.6	0.7	0.6	0.0	0.8	0.8
Miserableness	0.2	0.3	0.6	-0.3	0.8	-0.1	-0.5	0.0	0.5	0.3	0.6	0.8	0.8	0.1
Mother’s age at death	0.2	0.3	1.4	0.8	-0.8	-0.4	1.2	-0.1	-0.3	-0.2	0.2	-0.2	-0.0	0.2
Medication: Atorvastatin	0.2	0.2	1.4	0.3	0.3	1.2	0.1	-0.1	0.1	0.1	0.2	0.1	0.3	0.6
Illnesses of father: High blood pressure	0.2	0.3	1.6	-0.3	0.4	1.3	-0.7	0.0	0.4	0.3	0.2	0.3	0.3	0.3
Average weekly beer plus cider intake	0.2	0.3	0.9	-0.6	-0.4	0.1	0.8	-0.6	-0.4	-0.5	-0.7	-0.4	-0.9	-0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.0	0.0	0.3	0.8	0.3	0.5	0.4	0.6	0.5	-0.6	0.5
Myopia	0.2	0.3	2.2	-1.5	-0.1	0.1	0.2	-0.4	-0.3	-0.2	0.1	-0.4	-0.6	-0.1
Cholesterol lowering medication	0.2	0.3	2.3	-0.2	0.4	-0.7	-1.5	0.0	-0.2	-0.3	-0.3	0.6	-0.1	-0.2
Pack years of smoking	0.2	0.4	1.9	0.0	0.6	-0.3	0.6	1.4	0.4	0.4	0.2	0.6	0.8	0.1
Leg fat mass (left)	0.2	0.8	3.7	-1.1	-0.3	-0.8	1.9	0.7	-0.7	-0.8	-0.5	-0.4	-0.8	-0.5
Body Mass Index (BMI) (2010)	0.1	0.2	1.3	0.3	0.0	1.1	0.2	-0.6	0.1	0.2	0.2	-0.1	0.2	0.0
HDL Cholesterol	0.1	0.2	0.9	0.4	0.3	0.0	-0.4	0.5	0.4	0.1	-0.0	0.9	0.6	0.2
Blood Eosinophil Count	0.1	0.5	3.1	-0.4	0.4	0.4	1.8	0.4	-0.7	-0.7	-0.8	-0.6	-0.5	-0.4
Heel T-Score	0.1	0.5	2.9	0.1	-0.7	-0.0	1.7	-0.2	0.0	-0.2	-0.7	-0.8	-0.5	-0.4
BMI	0.1	0.8	2.8	-1.0	-0.9	0.9	-0.1	0.3	-1.1	-1.0	-0.8	-1.7	0.1	-1.0
Waist Hip Ratio (WHR)	0.1	0.2	0.8	-0.4	-0.1	-0.7	-0.4	0.9	0.1	0.1	-0.4	0.1	0.7	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.2	0.2	0.3	0.3	0.3	-0.7	-0.4	-0.7	-0.6	0.3	-0.3
Vitamin and mineral supplements	0.1	0.2	0.6	-0.2	-0.4	0.7	-0.2	-0.0	-0.5	-0.4	-0.3	-0.4	0.8	-0.4
Medication: Co-codamol	0.1	0.1	0.4	-0.3	-0.0	0.0	-0.2	-0.3	-0.4	-0.6	-0.1	-0.1	-0.3	-0.5
Hand grip strength (right)	0.1	0.3	1.5	0.2	-0.7	-1.0	1.2	-0.5	-0.2	0.0	0.3	0.2	-0.5	0.2
Multivitamins +/- minerals	0.1	0.1	0.6	0.3	-0.1	-0.8	-0.4	-0.1	0.3	0.2	0.2	0.4	-0.3	0.3
Number of incorrect matches in round	0.1	0.2	0.8	-0.3	-0.1	-0.6	-0.4	-0.3	0.5	0.2	0.3	0.9	0.7	0.4
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.7	-0.4	0.1	0.0	0.3	0.5	0.6	0.2	0.5	-0.0	0.2
Had menopause	0.1	0.1	0.5	0.5	0.3	-0.0	-0.1	0.7	0.1	0.1	0.1	0.2	-0.1	0.2
Mouth/teeth dental problems	0.1	0.1	0.4	0.0	0.2	0.4	-0.7	-0.4	0.0	0.1	-0.3	-0.2	0.5	0.0
Medication: Simvastatin	0.1	0.2	1.1	0.3	0.2	-0.4	-1.0	-0.0	-0.6	-0.3	-0.1	-0.3	0.1	-0.3
Medication: Cholesterol lowering	0.1	0.2	0.3	0.5	-0.1	0.5	-0.4	-0.4	-0.5	-0.5	-0.5	-0.2	-0.4	-0.3
Pulse wave reflection index	0.1	0.1	0.3	0.2	0.3	-0.5	-0.3	0.6	-0.2	-0.2	-0.4	0.3	-0.4	-0.5
Birth weight	0.1	0.3	0.9	0.4	0.1	-0.5	0.9	-0.8	0.3	0.2	0.4	0.9	-0.4	0.2
Leg fat percentage (right)	0.1	0.4	2.5	-0.3	0.3	-0.4	0.3	1.6	-0.5	-0.5	-0.6	-0.3	-0.3	-0.4
Wheeze or whistling in the chest in last year	0.1	0.2	1.3	-0.3	0.6	-0.0	0.4	0.6	0.3	0.1	-0.2	1.1	0.4	-0.3
Pulse rate, automated reading	0.1	0.4	1.5	0.2	0.5	1.2	-0.9	0.1	0.4	0.5	0.0	0.4	0.2	0.8
Overall health rating	0.1	0.2	1.8	-1.3	0.2	-0.0	0.3	0.2	-0.2	-0.3	-0.1	0.3	-0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.9	-0.6	-0.4	0.0	-0.1	0.2	0.5	0.1	0.0	0.9	-0.3	-0.2
Leg fat percentage (left)	0.1	0.4	3.4	-0.0	0.5	-0.5	0.1	1.9	-0.1	-0.2	-0.3	0.2	0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.5	-0.7	0.2	-0.3	-0.3	-0.1	-0.3	-0.4	0.1	0.4	-0.3	-0.0
Hair Pigment	0.0	1.1	3.2	0.8	0.4	1.1	1.0	1.1	1.2	1.0	0.7	1.8	0.5	1.0
Tanning	0.0	0.6	1.3	-1.1	-0.2	-0.2	-0.4	-0.0	-0.7	-0.9	-0.9	-1.1	-1.1	-0.9
Age when periods started (menarche)	0.0	0.1	0.5	-0.2	-0.2	-0.1	-0.2	-0.0	-0.2	-0.2	-0.5	-0.0	-0.7	-0.1
Worrier / anxious feelings	0.0	0.1	0.4	-0.2	-0.4	-0.5	-0.6	0.1	-0.0	-0.2	0.1	-0.1	-0.0	-0.4

Hub : Genes

PNPT1

Models

Trait associations