TWAS hub - CYP26B1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0220	4.6e-04	0.007	0.027	0.004	0.027	0.014	4.0e-02	2.6e-04	9.3e-02	2.9e-04	7.2e-03
2	GTEx	Whole Blood	0.1240	0.0330	1.0e-08	0.144	NA	0.156	NA	0.151	3.2e-13	NA	3.2e-14	NA	8.5e-14
3	NTR	Blood	0.0418	0.0149	3.0e-06	0.026	0.017	0.026	0.022	0.028	7.8e-09	2.6e-06	7.9e-09	6.9e-08	1.4e-09
4	ROSMAP	Brain Pre-frontal Cortex	0.0414	0.0158	1.2e-04	0.019	0.021	0.012	0.018	0.004	1.6e-03	9.3e-04	9.7e-03	2.0e-03	8.5e-02
5	TCGA	Glioblastoma Multiforme	0.1870	0.0880	5.4e-03	0.013	-0.004	-0.009	NA	-0.002	1.2e-01	4.4e-01	7.3e-01	NA	3.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Medication: Bendroflumethiazide	3.6	5.5	12.0	-3.5	-2.0	-2.4	-2.3	0.5
Bipolar Disorder (2018)	3.4	5.4	10.4	-2.5	-2.5	-3.2	-0.2	2.1
Average weekly red wine intake	3.4	5.0	10.6	1.4	1.7	2.7	3.3	1.3
Diastolic blood pressure, automated reading	3.4	10.5	17.9	-3.8	-4.2	-3.6	-2.6	0.8
Hand grip strength (right)	3.3	9.1	18.2	3.2	2.5	2.9	4.3	1.4
High blood pressure (siblings)	3.3	4.7	9.9	-3.1	-2.2	-2.2	-1.7	-1.0
Handedness (chirality/laterality): Left-handed	3.3	4.0	9.8	0.0	-0.3	-1.1	-3.0	-3.1
Hand grip strength (left)	3.0	7.9	16.2	3.0	2.7	2.4	4.0	1.0
Schizophrenia vs Biploar Disorder	2.9	3.8	7.2	2.4	1.3	2.0	0.6	-2.7
Diverticular disease/diverticulitis (self-reported)	2.9	3.4	6.2	-1.2	-1.8	-2.0	-2.5	-1.4
Ovarian Cancer	2.8	3.8	12.8	-3.6	-1.7	-1.3	-1.1	0.4
Family relationship satisfaction	2.8	3.5	5.7	-2.0	-2.0	-2.4	-1.5	1.2
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.3	6.8	0.2	-2.6	-2.5	-1.9	-0.4
Health satisfaction	2.7	3.6	9.2	-3.0	-1.3	-0.9	-2.4	0.5
Mineral and other dietary supplements	2.7	3.7	5.6	-2.2	-1.7	-1.9	-2.4	-1.1
Hair/balding pattern: Pattern 2	2.6	3.4	4.3	2.1	1.6	1.7	1.6	-2.0
Qualifications: None of the above	2.6	5.6	16.2	-4.0	-1.2	-2.0	-2.2	-1.2
Qualifications: O levels/GCSEs or equivalent	2.6	4.1	7.6	2.7	1.6	2.0	2.6	0.1
Wears glasses or contact lenses	2.6	2.9	7.3	2.2	1.1	0.9	2.7	-0.7
Eye problems/disorders: Glaucoma	2.6	3.0	4.5	-1.5	-1.9	-2.1	-1.9	-1.0
Bipolar Disorder (2011)	2.5	2.4	5.9	-1.0	-2.4	-2.2	-0.6	0.3
Chronotype (morning person)	2.5	5.8	7.9	2.8	2.7	2.6	2.6	-0.6
Qualifications: College or University degree	2.4	7.7	12.9	3.6	2.3	2.6	3.5	1.1
Financial situation satisfaction	2.4	3.0	8.7	-3.0	-0.9	-0.9	-2.1	0.2
Cardiovascular Disease	2.3	7.6	14.4	-3.8	-2.4	-2.7	-3.3	-0.2
Supplements: Glucosamine	2.3	3.0	5.3	1.9	1.6	2.3	1.7	-0.6
Exposure to tobacco smoke at home	2.3	2.6	4.8	-1.6	-2.0	-2.2	-1.4	0.1
Ever smoked	2.3	4.1	6.7	2.0	2.1	2.2	2.6	-0.7
Risk taking	2.3	3.4	6.2	1.8	1.8	2.5	2.0	-0.2
Ulcerative Colitis (UC)	2.2	4.2	8.4	-2.9	-1.4	-1.7	-2.1	1.8
Lupus	2.2	3.4	6.2	1.5	1.9	2.5	2.0	0.9
Height	2.2	42.9	108.2	3.4	5.2	5.1	10.4	6.4
Past tobacco smoking	2.2	4.1	7.1	-1.3	-2.5	-2.7	-2.1	1.2
Loud music exposure frequency	2.2	2.4	8.4	0.0	-0.6	-0.5	-2.9	-1.8
Systolic blood pressure, automated reading	2.1	6.0	9.3	-2.7	-3.0	-2.9	-2.3	0.0
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	9.5	1.5	2.0	3.1	1.5	2.4
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	7.2	2.4	1.6	2.7	1.0	-0.7
Comparative height size at age 10	2.1	11.5	35.5	0.7	1.7	1.8	3.9	6.0
Eye problems/disorders: Cataract	2.1	2.5	5.4	1.7	1.4	2.3	1.3	0.6
Supplements: Fish oil (including cod liver oil)	2.1	2.8	4.5	1.3	1.8	2.0	2.1	0.6
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	4.9	2.2	1.5	1.3	0.3	-1.9
Systolic Blood Pressure	2.0	10.1	21.0	-4.6	-3.4	-3.4	-2.5	0.3
Average weekly spirits intake	2.0	2.5	6.4	-0.7	-0.8	-1.8	-2.5	-1.4
Qualifications: CSEs or equivalent	2.0	2.6	4.5	-2.1	-2.1	-1.6	-1.3	-0.1
Had other major operations	2.0	2.5	5.7	-0.8	-2.0	-0.7	-2.4	-1.3
Alcohol drinker status: Never	2.0	2.3	6.5	-2.6	-1.0	-1.0	-1.8	-0.3
Commuting to job workplace: Cycle	2.0	2.5	6.9	1.2	1.4	1.3	2.6	0.6
Irritable Bowel Disease (IBD)	1.9	4.5	7.0	-2.6	-1.9	-2.4	-2.6	0.0
Multivitamins +/- minerals	1.9	2.4	3.9	1.4	2.0	1.7	1.6	0.8
Chronic bronchitis/emphysema (father)	1.9	2.3	5.5	1.4	1.6	2.4	0.8	-0.6
Number of incorrect matches in round	1.9	3.2	7.2	2.3	1.0	0.2	2.7	1.5
Crohns Disease (2017)	1.8	3.9	4.9	-1.7	-2.0	-2.2	-2.1	-1.8
Medication: Blood pressure	1.8	3.2	5.4	-2.3	-1.6	-2.0	0.2	2.0
Medication: Aspirin	1.8	2.4	4.4	-1.9	-1.2	-2.1	-1.6	0.5
Glaucoma (self-reported)	1.7	1.9	3.5	-0.5	-1.8	-1.9	-1.5	-0.5
Number of children fathered	1.7	1.9	3.1	1.8	1.5	0.9	1.6	-1.1
Alcohol usually taken with meals	1.6	2.7	5.5	2.2	1.0	1.0	2.4	1.0
Blood Platelet Count	1.5	17.0	25.8	-3.8	-5.1	-4.4	-4.6	-2.0
Medication: Co-codamol	1.5	1.8	4.6	-1.7	-0.9	-0.4	-2.1	-0.6
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.7	0.7	1.1	1.1	1.6	1.6
Standing height	1.5	14.8	34.1	1.3	2.2	2.4	5.8	5.3
Shortness of breath walking on level ground	1.5	1.8	2.6	-1.6	-0.9	-1.2	-1.6	-1.5
Medication: Omeprazole	1.5	1.8	3.8	1.8	1.0	1.1	-0.0	-2.0
Intelligence (Savage-Jansen 2018)	1.4	4.3	6.1	1.2	2.3	2.3	2.5	1.8
Heel T-Score	1.4	11.0	34.6	-1.7	0.5	3.7	1.9	5.9
Frequency of depressed mood in last 2 weeks	1.4	1.9	5.3	-1.8	-0.7	-0.7	-2.3	0.1
Trunk fat-free mass	1.4	7.9	16.9	1.8	1.4	1.8	4.1	3.8
Trunk predicted mass	1.4	7.9	16.8	1.8	1.4	1.8	4.1	3.7
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.8	-1.3	-1.3	-0.9	-1.9	-1.1
Illnesses of father: Heart disease	1.4	2.0	6.0	-0.4	-1.2	-1.2	-1.0	-2.5
Mother’s age at death	1.4	1.8	2.7	1.6	1.3	0.9	1.6	1.1
Major Depression (MDD)	1.3	1.6	5.1	-0.8	-1.3	-0.7	0.3	2.2
Verbal and Numeric Reasoning (VNR)	1.3	3.0	4.4	1.7	2.1	2.0	1.6	1.1
Fed-up feelings	1.3	2.3	5.0	1.2	2.2	1.9	1.0	-0.8
High blood pressure	1.3	3.6	9.0	-3.0	-1.5	-1.8	-1.5	0.9
Medication: Lansoprazole	1.3	1.5	3.2	-1.2	-0.9	-1.8	-0.7	1.3
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.1	1.2	1.3	0.8	-0.6	-1.8
Overall health rating	1.3	2.7	6.0	-2.0	-1.2	-1.3	-2.5	-0.7
Qualifications: nursing, teaching	1.3	2.0	3.9	2.0	1.6	1.2	1.2	0.7
Number of operations (self-reported)	1.3	2.0	3.1	-0.7	-1.7	-1.8	-1.5	-1.1
Vascular/heart problems diagnosed by doctor	1.3	3.6	8.4	2.9	1.6	2.2	1.3	-0.8
Fasting Glucose	1.2	1.4	3.9	1.4	0.7	-0.8	0.1	-2.0
Supplements: Zinc	1.2	1.3	2.2	1.3	1.1	1.0	1.5	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.8	-1.9	-0.4	-0.3	-1.0	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.5	0.8	1.2	2.2	0.9	2.5
Whole body fat-free mass	1.2	6.6	13.2	1.8	1.1	1.6	3.6	3.6
Long-standing illness, disability or infirmity	1.2	1.8	3.5	-1.6	-1.2	-1.1	-1.9	-0.5
Whole body water mass	1.2	6.8	13.7	1.8	1.1	1.5	3.7	3.7
Unable to work because of sickness or disability	1.2	1.6	4.4	-1.7	-0.7	0.4	0.3	2.1
Depression (Nagel 2018)	1.1	1.7	3.3	-1.8	-0.8	-0.6	-1.8	1.0
Blood White Count	1.1	7.8	15.0	-3.2	-2.8	-2.1	-3.9	-1.5
Lung FVC	1.1	5.4	14.6	-2.2	-3.8	-1.6	-1.0	1.9
Leg fat-free mass (left)	1.1	5.8	11.5	2.0	1.0	1.6	3.1	3.4
Forced vital capacity (FVC)	1.1	4.4	15.7	-1.1	-0.9	0.1	2.1	4.0
Pain all over the body in last month	1.1	1.2	2.4	-1.4	-0.6	-0.7	-0.7	1.5
Fluid intelligence score	1.1	2.3	3.2	1.0	1.8	1.5	1.8	1.4
Illnesses of siblings	1.1	1.5	5.2	2.3	0.8	1.0	0.7	0.1
Number of live births	1.1	1.5	3.6	0.8	0.9	1.5	0.3	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.3	1.4	0.9	0.2	0.2	-1.8
Breastfed as a baby	1.1	1.3	2.4	-0.1	-1.1	-1.0	1.6	1.5
Arm predicted mass (right)	1.1	5.8	14.8	0.9	0.9	1.2	3.3	3.9
Loneliness, isolation	1.1	1.6	4.2	-2.0	-0.2	-0.2	-1.9	-0.1
Commuting to job workplace: Walk	1.1	1.2	3.1	-1.2	-0.9	-0.5	0.7	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.8	-0.9	-1.7	-0.9	-0.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	4.3	-1.8	-2.0	-0.8	-0.3	2.1
Alzheimer’s Disease (in mother)	1.0	1.2	3.7	-1.9	-0.6	-0.6	-1.2	0.4
Alzheimer’s Disease (in father)	1.0	1.0	1.9	1.2	0.7	0.7	1.4	-0.9
Coronary Artery Disease (CAD)	1.0	1.1	2.9	-0.8	-0.9	-0.6	-1.7	-1.1
Crohns Disease (2012)	1.0	1.6	3.2	-0.5	-0.8	-1.8	-0.9	-1.8
Ulcerative Colitis	1.0	1.5	3.4	-1.8	-0.3	-1.4	-1.1	1.0
Leg predicted mass (left)	1.0	5.5	11.5	1.9	0.9	1.5	3.0	3.4
Mouth/teeth dental problems	1.0	1.5	3.8	-1.6	-1.9	-1.1	-0.3	0.2
Birth weight	1.0	2.1	5.3	0.6	1.5	0.4	2.3	1.6
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.8	-0.9	-1.3	-1.4	-1.2	-0.3
Forced vital capacity (FVC), Best measure	1.0	3.8	11.2	-0.0	0.1	0.9	2.7	3.4
Arm fat-free mass (right)	1.0	5.0	13.1	0.9	0.8	1.0	3.1	3.6
Age at first live birth	1.0	1.8	3.6	-0.5	1.6	0.8	1.9	1.3
Hypertension (Self-reported)	1.0	2.8	8.9	-3.0	-1.0	-1.3	-1.2	0.9
Miserableness	1.0	1.8	2.9	0.9	1.7	1.7	1.5	-0.4
Basal metabolic rate	1.0	5.7	13.5	1.6	0.9	1.4	3.1	3.7
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.1	1.4	0.3	1.4	0.8	-0.9
Supplements: Calcium	1.0	1.1	2.9	-0.1	-1.3	-1.7	-0.0	0.8
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	0.4	-1.2	-0.8	0.2	-1.7
Angina	0.9	1.2	1.9	-1.1	0.9	0.7	-1.3	-1.4
Vitamin and mineral supplements	0.9	1.3	1.8	-1.3	-1.2	-1.1	-1.3	-0.4
Diabetes (father)	0.9	1.2	3.1	1.8	0.3	0.6	0.1	-1.5
Medication: Cholesterol lowering	0.9	1.4	4.0	-1.6	-0.5	-2.0	-0.1	0.1
Angina (self-reported)	0.9	1.1	2.5	-0.9	0.7	0.6	-1.2	-1.6
Leg fat-free mass (right)	0.9	5.0	11.8	1.8	0.7	1.3	2.9	3.4
Leg predicted mass (right)	0.9	4.9	11.4	1.8	0.7	1.3	2.8	3.4
Medication: Blood pressure	0.9	1.8	4.1	-2.0	-0.3	-0.7	-1.7	-1.1
Arm predicted mass (left)	0.9	4.8	13.0	1.0	0.8	1.1	2.8	3.6
Rheumatoid Arthritis	0.8	1.1	2.7	0.1	1.6	1.4	0.4	0.7
Diabetes (mother)	0.8	1.0	3.6	-0.2	-0.4	-0.2	-1.9	-1.1
Medication: Levothyroxine sodium	0.8	1.4	1.9	-0.5	-1.3	-1.4	-1.3	-1.2
Had menopause	0.8	1.0	4.6	0.2	0.5	-0.4	-0.3	-2.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.7	1.3	0.7	0.9	1.2	0.8
Happiness	0.8	1.0	3.0	-1.3	-0.0	-0.3	-0.2	1.7
Noisy workplace	0.8	1.0	2.5	-1.6	-0.3	-0.3	-1.5	-0.3
Depression (self-reported)	0.8	1.0	1.3	1.1	1.0	1.1	1.0	0.7
Birth weight of first child	0.8	1.4	3.4	1.2	0.5	-0.6	1.8	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	4.3	-0.4	-0.2	0.2	-0.7	-2.1
Chest pain or discomfort	0.8	1.1	2.8	-1.6	-0.3	0.4	-1.7	-0.5
Commuting to job workplace: Public transport	0.8	1.0	3.3	-0.3	0.0	-0.1	-1.2	-1.8
Illnesses of father: High blood pressure	0.8	1.0	3.3	-1.8	-0.6	-0.5	-0.9	0.7
Arm fat-free mass (left)	0.8	4.1	11.1	1.0	0.8	1.0	2.6	3.3
Average weekly beer plus cider intake	0.8	1.2	2.8	-0.8	-1.2	-1.7	-0.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.1	-1.1	-0.4	-1.1	-1.4	0.5
Depressed Affect (Nagel 2018)	0.7	1.5	3.7	0.6	1.9	1.6	0.2	-1.0
Triglycerides	0.7	1.2	3.2	0.1	1.8	1.5	0.4	-0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.7	0.9	1.0	1.3	0.8	0.1
Smoking Status	0.7	1.6	3.1	0.7	1.8	1.7	1.0	-0.9
Medication: Metformin	0.7	1.1	2.2	0.7	0.8	0.5	1.3	1.5
Medication: Atenolol	0.7	0.8	2.5	-1.6	0.8	-0.3	-1.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.1	-0.0	1.5	1.5	0.5	0.9
Medication: Ramipril	0.7	0.9	3.1	-1.3	0.0	-0.1	0.0	1.8
Pulse rate	0.7	1.1	3.9	-1.1	-0.4	-0.3	-0.0	2.0
Prospective memory result	0.7	0.8	1.4	1.2	0.8	-0.2	1.1	-0.8
Length of working week for main job	0.7	0.8	1.5	0.8	1.2	0.6	-0.5	-1.1
Blood clot in the leg (DVT)	0.7	0.9	1.7	-1.0	-0.2	-1.0	-1.3	0.8
Medication: Amlodipine	0.7	1.0	2.6	-0.8	-1.2	-1.6	0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.2	-0.7	0.5	0.8	1.1	1.5
Age at last live birth	0.7	1.0	3.1	-0.0	1.8	0.9	1.1	-0.2
Medication: Aspirin	0.7	1.0	2.0	-1.3	-0.4	-1.4	-0.9	0.5
Knee pain experienced in last month	0.7	1.1	4.4	-2.1	0.8	0.2	0.5	0.2
Smoking status: Previous	0.7	1.1	2.6	0.3	1.3	1.6	0.4	-0.9
Ever taken oral contraceptive pill	0.7	0.8	3.6	-0.1	0.0	0.4	0.3	-1.9
Irritability	0.7	1.3	3.2	0.4	0.8	1.2	1.8	0.8
Basal cell carcinoma (self-reported)	0.7	0.8	3.4	1.8	0.4	0.5	0.6	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.4	2.8	-0.4	-1.3	-1.4	0.5	1.7
Neuroticism (Nagel 2018)	0.6	1.3	3.1	0.2	1.4	1.8	1.1	0.4
Mean Putamen Volume	0.6	0.7	1.7	1.3	-0.8	-0.4	-0.4	-0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	-1.0	-0.3	-1.3	-0.5	0.6
Average weekly fortified wine intake	0.6	0.7	2.0	-0.2	-0.9	-0.6	-0.1	1.4
Serious illness, injury or assault to yourself	0.6	0.7	1.5	-1.2	-0.5	-0.1	-1.0	1.0
Alcohol intake versus 10 years previously	0.6	0.9	2.4	0.7	0.3	-0.3	1.3	1.6
Father’s age at death	0.6	0.8	2.1	1.5	0.7	0.4	0.9	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.7	-1.1	-1.3	-0.8	-0.8	0.8
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	8.4	-0.8	-0.6	0.3	1.0	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	7.2	-0.1	-0.1	0.3	1.4	2.7
Supplements: Vitamin C	0.6	0.7	1.3	1.2	1.0	0.7	0.9	-0.1
Illnesses of siblings: Diabetes	0.6	0.7	1.6	-0.6	1.0	0.2	0.7	1.3
Breast cancer (self-reported)	0.6	0.7	2.2	-0.9	-0.5	-0.5	-1.5	-0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	2.2	-1.1	0.3	-0.0	0.3	1.5
Fractured/broken bones in last 5 years	0.6	0.8	1.7	-0.4	-0.5	-1.3	-1.2	0.6
Myopia	0.6	0.8	1.9	-0.7	0.6	-1.2	-0.2	1.4
Pain experienced in last month	0.6	1.0	2.0	1.4	0.4	0.9	1.3	0.4
Alcohol drinker status: Previous	0.6	0.7	2.1	0.9	0.1	0.3	-1.4	-0.7
Neuroticism (2016)	0.5	0.8	1.7	-1.3	-0.7	-1.0	0.3	0.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.8	-1.2	-0.7	-1.4	-0.4	0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	-0.2	-0.5	-0.6	-1.0	-1.2
Medication for hormone replacement therapy	0.5	0.5	1.3	0.6	0.5	-0.1	-1.1	-0.9
Severe depression (siblings)	0.5	0.6	1.2	-1.1	-0.7	-0.1	-0.8	0.8
Townsend deprivation index at recruitment	0.5	0.8	1.5	-1.1	-0.5	-1.2	-0.8	0.3
Impedance of leg (left)	0.5	2.4	7.1	-2.7	-0.5	-1.2	-1.7	-0.7
Heart attack	0.5	0.7	1.7	-0.4	1.1	1.3	-0.5	0.4
Weight	0.5	2.2	9.5	0.6	0.1	0.6	1.0	3.1
Hip circumference	0.5	2.0	7.6	-0.8	-0.8	-0.3	-1.0	2.8
Falls in the last year	0.5	0.6	1.5	-1.1	0.3	-0.5	-0.5	-1.2
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.4	0.8	0.5	1.1	1.6	1.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.6	0.4	1.3	0.9	0.6	-0.1
Medication: Allopurinol	0.5	0.7	2.2	0.2	0.4	0.4	1.1	1.5
Number of full sisters	0.5	0.6	1.6	-0.7	-0.1	-0.3	-1.0	-1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.9	-0.1	-0.5	-0.5	0.9	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	3.1	0.3	-0.1	-0.1	1.8	1.2
Mood swings	0.5	0.8	2.9	0.0	0.9	0.6	0.0	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.5	-0.6	1.6	0.5	0.1	0.8
Medication for cholesterol	0.5	0.8	1.7	0.9	-0.5	0.2	1.3	1.0
Number of self-reported non-cancer illnesses	0.5	0.8	2.1	-0.9	-0.7	-0.9	0.2	1.4
Guilty feelings	0.5	0.7	2.9	-1.7	0.1	0.5	-0.4	0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.5	-0.0	-0.5	-1.6	0.0	-0.8
Medication: Lisinopril	0.5	0.6	2.0	-0.9	0.3	0.3	0.3	-1.4
Age started oral contraceptive pill	0.5	0.6	2.3	0.3	0.4	-0.0	0.8	-1.5
Cholesterol lowering medication	0.5	0.7	2.2	0.2	0.1	-0.0	-1.5	-1.2
Schizophrenia (2018)	0.4	0.8	2.5	1.6	0.3	0.8	0.8	0.4
Alzheimer’s Disease (including proxy)	0.4	0.5	1.4	-0.5	0.8	0.6	1.2	-0.1
Prostate Cancer	0.4	0.5	1.3	-0.5	-1.1	-0.7	-0.7	-0.1
Respiratory disease	0.4	1.0	1.8	-0.8	-1.1	-1.4	-0.5	0.9
Maternal smoking around birth	0.4	0.6	2.7	0.0	-0.0	-0.2	1.6	0.5
Relative age voice broke	0.4	0.7	0.9	0.7	0.7	1.0	0.7	0.9
Age when periods started (menarche)	0.4	0.9	2.4	0.9	1.6	1.0	0.4	-0.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	1.2	-0.8	-0.5	-0.0	-0.2
Sitting height	0.4	2.9	8.9	-2.0	-1.1	-0.0	-0.1	3.0
High blood pressure (mother)	0.4	0.5	1.4	-0.2	0.8	0.1	0.6	-1.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	-0.3	-0.6	-0.1	-1.2	-0.8
Allergy	0.4	0.9	1.7	0.9	0.9	1.1	1.3	-0.5
Time employed in main current job	0.4	0.4	1.7	1.3	-0.3	0.0	0.6	-0.0
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	0.0	-0.3	-0.6	-0.9	-1.4
Hair/balding pattern: Pattern 4	0.4	0.9	2.3	0.7	1.5	0.9	-0.0	1.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-1.0	-0.7	0.1	-1.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.3	0.7	0.3	0.3	-1.1	0.9
Exposure to tobacco smoke outside home	0.4	0.6	1.0	-0.6	-1.0	-0.4	-0.9	0.7
Comparative body size at age 10	0.4	1.1	2.0	-0.6	-1.2	-1.0	-0.9	1.4
Emphysema/chronic bronchitis	0.4	0.4	0.7	-0.8	-0.5	-0.8	0.1	0.7
Neck or shoulder pain in last month	0.4	0.5	1.7	-1.3	0.0	-0.7	-0.4	0.2
Migraine (self-reported)	0.4	0.4	0.8	0.1	-0.8	-0.9	-0.9	0.1
Diabetes diagnosed by doctor	0.4	0.7	2.6	-0.7	-0.0	-0.5	0.3	1.6
Osteoporosis (self-reported)	0.4	0.5	1.3	-0.5	-0.4	-0.1	-1.1	-0.8
Osteoarthritis (self-reported)	0.4	0.5	1.1	0.9	0.5	0.1	-0.5	-1.0
Average weekly champagne plus white wine intake	0.4	0.5	1.5	1.2	0.1	0.6	0.3	0.7
Medication: Paracetamol	0.4	0.6	1.1	-0.5	0.2	-0.7	-1.1	-1.0
Leg fat percentage (left)	0.4	1.6	4.8	-0.9	-0.8	-1.0	-2.2	0.9
Ever depressed for a whole week	0.4	0.5	1.7	-0.3	-1.3	-0.3	-0.9	-0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.6	-0.3	1.0	1.2	-0.5	0.1
Breast Cancer	0.3	0.7	1.7	1.1	0.0	0.1	1.3	0.9
HDL Cholesterol	0.3	0.5	2.3	0.1	0.5	0.4	0.1	-1.5
LDL Cholesterol	0.3	0.4	1.3	-0.9	0.0	-0.2	-1.1	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.2	-0.3	-0.9	0.2	1.0
Schizophrenia (2014)	0.3	0.6	1.3	1.1	-0.2	-0.1	0.9	0.8
Blood Eosinophil Count	0.3	2.2	7.3	-1.1	-0.8	-0.1	1.3	2.7
Hearing difficulty/problems: Yes	0.3	0.4	1.3	0.0	0.3	0.4	-0.7	-1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	-0.8	-0.7	-0.1	-0.4	-0.8
Current tobacco smoking	0.3	0.4	1.4	-0.3	-0.5	-0.7	-0.0	-1.2
Taking other prescription medications	0.3	0.4	1.2	0.1	0.6	-0.1	0.7	1.1
Trunk fat mass	0.3	1.3	6.1	0.4	-0.1	0.3	0.1	2.5
Financial difficulties in last 2 years	0.3	0.4	1.6	-0.1	0.4	0.5	-0.3	1.3
Diabetes (self-reported)	0.3	0.5	1.4	-0.6	-0.1	-0.9	0.1	1.2
Arm fat percentage (right)	0.3	1.1	3.7	0.1	-0.8	-0.4	-1.9	0.9
Hair/balding pattern: Pattern 3	0.3	0.5	1.1	-1.0	-0.5	-0.7	-0.8	0.3
Illnesses of mother	0.3	0.3	1.0	1.0	0.4	0.5	0.2	0.5
Tense / ‘highly strung’	0.3	0.5	1.5	-0.1	-0.5	0.4	0.7	1.2
Peak expiratory flow (PEF)	0.3	0.6	1.5	-1.0	0.4	0.3	0.6	1.2
Medication: Paracetamol	0.3	0.6	1.6	0.3	0.9	0.0	-0.6	-1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.8	-0.8	-0.6	-0.9	-0.9	-0.1
Number of full brothers	0.3	0.3	1.1	0.5	-0.1	-0.1	-0.6	-1.1
Worry too long after embarrassment	0.3	0.5	1.4	0.2	0.7	1.2	0.5	0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.2	0.2	1.1	0.9	0.9	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.2	-0.0	0.4	-0.3	1.1	0.8
Pulse wave peak to peak time	0.3	0.4	1.4	-0.2	-1.2	-0.7	-0.2	0.4
Eye problems/disorders: None of the above	0.3	0.3	1.2	-0.4	0.3	-0.1	0.5	-1.1
Medication for pain relief, constipation, heartburn	0.3	0.6	1.1	-0.8	-1.0	0.3	0.2	1.1
Whole body fat mass	0.3	1.1	5.0	0.5	0.2	0.4	-0.1	2.2
Pulse rate, automated reading	0.3	1.0	1.6	-0.9	-1.3	-0.9	-0.7	1.1
Leg pain on walking	0.3	0.4	0.9	-0.7	0.6	0.4	0.3	0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	0.4	0.3	0.7	0.9	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.3	1.2	-0.2	-0.2	-0.3	-0.6
Arm fat percentage (left)	0.3	1.0	2.9	0.1	-0.8	-0.3	-1.7	1.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	-0.2	1.0	0.6	0.1	-0.4
Medication: Atorvastatin	0.3	0.3	0.9	-0.7	-0.1	0.4	-0.9	-0.3
Heart disease (siblings)	0.3	0.3	0.8	-0.5	-0.9	-0.6	-0.4	0.3
Reaction Time	0.2	0.5	1.3	-1.1	-0.5	-0.5	-0.7	0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.7	-0.9	0.2	-0.1	0.4
HbA1C	0.2	0.2	0.5	-0.1	-0.6	-0.3	-0.4	-0.7
Allergy or Eczema	0.2	0.4	1.2	0.9	-0.5	0.1	0.1	1.1
Hypothyroidism (self reported)	0.2	0.5	1.3	-1.1	-0.4	-0.5	-0.6	0.8
Lung FEV1/FVC ratio	0.2	1.2	5.3	-0.5	-0.2	-0.5	-2.3	-0.3
Number of treatments/medications taken	0.2	0.3	0.5	-0.5	0.5	-0.7	0.3	0.7
Relative age of first facial hair	0.2	0.3	1.1	-0.6	-0.4	-0.2	-0.4	1.0
Pack years adult smoking proportion	0.2	0.2	0.6	-0.2	-0.8	0.7	0.0	-0.4
Impedance of leg (right)	0.2	0.9	2.8	-1.7	0.5	-0.1	-0.8	-0.9
Trunk fat percentage	0.2	0.8	2.5	-0.1	-0.6	-0.3	-1.1	1.6
Stomach or abdominal pain in last month	0.2	0.3	0.7	0.5	-0.4	-0.8	-0.1	0.5
Body mass index (BMI)	0.2	0.7	2.1	0.3	-0.7	-0.4	-1.5	0.7
Waist circumference	0.2	0.9	2.7	-0.6	-0.7	0.0	-1.0	1.6
Nervous feelings	0.2	0.4	0.6	-0.2	-0.5	-0.8	0.5	0.8
Medication: Simvastatin	0.2	0.3	0.7	0.0	0.8	-0.8	-0.0	-0.3
Worrier / anxious feelings	0.2	0.4	0.7	0.2	0.3	0.9	0.6	0.7
Asthma	0.2	0.4	1.5	-0.5	-0.1	-0.4	-0.2	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.8	0.6	0.3	-0.1	0.0
Arm fat mass (right)	0.2	0.8	3.5	0.3	-0.4	-0.1	-0.6	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.3	0.4	-0.6	0.4	0.5	0.6
Gout (self-reported)	0.2	0.2	0.5	-0.3	-0.2	0.7	0.4	0.7
Body fat percentage	0.2	0.9	2.2	-0.3	-0.5	-0.3	-1.5	1.4
Leg fat percentage (right)	0.2	0.7	2.9	-0.2	-0.3	-0.4	-1.7	0.5
Medication: Ibuprofen	0.2	0.2	0.6	0.3	-0.2	-0.7	-0.8	-0.1
Mean time to correctly identify matches	0.2	0.4	0.6	-0.8	-0.7	-0.6	-0.3	0.6
Heart disease (mother)	0.2	0.2	0.5	-0.2	-0.3	0.2	0.7	-0.7
Leg fat mass (right)	0.2	0.7	3.3	0.0	0.0	0.0	-0.6	1.8
Alcohol intake frequency.	0.2	0.5	1.4	0.6	0.5	0.8	-1.2	-0.2
Suffer from ‘nerves’	0.2	0.3	0.9	-1.0	0.7	0.5	-0.3	-0.1
Had major operations	0.2	0.3	0.6	0.8	0.1	-0.5	0.4	0.6
Back pain experienced in last month	0.2	0.3	0.7	-0.9	-0.6	-0.5	0.1	-0.1
Asthma (self-reported)	0.2	0.3	1.2	-0.4	-0.0	-0.3	-0.2	1.1
Smoking status: Current	0.2	0.3	0.8	0.2	0.3	-0.0	0.7	-0.9
Arm fat mass (left)	0.2	0.9	3.9	0.4	-0.3	0.1	-0.6	2.0
Hearing aid user	0.2	0.2	0.6	-0.8	-0.5	0.4	-0.2	0.0
Impedance of whole body	0.2	1.1	2.5	-1.6	-0.4	-0.7	-1.4	-0.8
Leg fat mass (left)	0.2	0.8	3.5	-0.2	-0.1	-0.1	-0.7	1.9
Worry (Nagel 2018)	0.1	0.1	0.4	0.1	-0.1	0.1	0.5	0.6
Age at First Birth	0.1	0.1	0.4	0.1	-0.7	-0.2	0.4	-0.0
Blood Red Count	0.1	1.4	3.3	1.0	1.3	1.8	0.3	-1.0
BMI	0.1	0.9	2.4	0.2	-0.9	-0.9	-1.6	0.4
Waist Hip Ratio (WHR)	0.1	0.5	1.6	-1.3	-0.4	0.4	-0.7	0.0
Tanning	0.1	1.4	2.8	0.8	0.9	1.7	1.6	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.7	-0.1	-0.2	-0.4	-0.0	0.9
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.6	-0.6	-0.1	-0.7	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.7	-0.1	-0.1	-0.8	0.1	0.5
Impedance of arm (right)	0.1	0.3	0.8	-0.2	-0.1	0.0	-0.8	-0.9
Lung cancer (father)	0.1	0.1	0.5	0.1	0.7	0.0	0.2	0.1
Pulse wave reflection index	0.1	0.2	0.6	0.2	-0.3	-0.8	0.2	0.2
Headache pain in last month	0.1	0.2	1.0	0.3	0.3	0.3	-1.0	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.3	0.4	-0.2	-0.4	0.5
Ever had bowel cancer screening	0.1	0.1	0.4	0.0	0.1	0.7	-0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.2	0.1	-0.1	0.5	-0.1
Friendships satisfaction	0.1	0.2	0.4	0.3	0.6	0.2	0.5	-0.2
Medication: Gliclazide	0.1	0.1	0.5	0.1	-0.0	0.4	0.7	0.2
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.4	0.3	-0.3	0.0	-0.3
Pack years of smoking	0.1	0.2	0.5	-0.0	-0.5	0.7	0.2	-0.1
Neuroticism	0.0	0.1	0.3	0.6	0.3	-0.1	0.1	0.1
Hair Pigment	0.0	0.9	2.0	0.7	0.2	0.0	1.4	1.4
Neuroticism score	0.0	0.1	0.2	-0.2	0.4	0.4	0.2	-0.1
Impedance of arm (left)	0.0	0.2	0.5	-0.4	-0.4	-0.2	-0.7	0.1

Hub : Genes

CYP26B1

Models

Trait associations