Best TWAS P=8.28e-55 · Best GWAS P=2.55e-44 conditioned to 0.0344
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | CTPS1 | 0.10 | 0.00 | enet | 8 | 0.00 | 4.6e-01 | 9.78 | 10.8 | 5.1e-27 | 0.75 | 0.05 | 0.60 | FALSE |
2 | GTEx | Artery Coronary | CTPS1 | 0.25 | -0.01 | enet | 23 | 0.00 | 3.0e-01 | 0.45 | 7.3 | 2.7e-13 | 0.38 | 0.07 | 0.13 | FALSE |
3 | GTEx | Brain Cerebellum | FOXO6 | 0.35 | 0.33 | enet | 21 | 0.36 | 1.2e-11 | 3.87 | 7.1 | 1.5e-12 | -0.02 | 1.00 | 0.00 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | CTPS1 | 0.12 | -0.01 | lasso | 4 | -0.01 | 7.5e-01 | 11.25 | 10.5 | 9.2e-26 | 0.61 | 0.04 | 0.10 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | CTPS1 | 0.26 | 0.11 | lasso | 6 | 0.08 | 1.6e-03 | 11.23 | 10.8 | 4.9e-27 | 0.70 | 0.19 | 0.35 | FALSE |
6 | GTEx | Colon Transverse | SCMH1 | 0.16 | 0.07 | enet | 21 | 0.06 | 1.3e-03 | 0.99 | -7.0 | 3.5e-12 | -0.22 | 0.22 | 0.09 | FALSE |
7 | GTEx | Lung | CTPS1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 2.4e-04 | 11.26 | 12.6 | 1.7e-36 | 0.77 | 0.22 | 0.62 | FALSE |
8 | GTEx | Nerve Tibial | SCMH1 | 0.16 | 0.03 | enet | 24 | 0.07 | 1.6e-05 | 13.31 | -13.1 | 1.8e-39 | -0.70 | 0.04 | 0.95 | FALSE |
9 | GTEx | Testis | SLFNL1 | 0.30 | 0.17 | lasso | 14 | 0.28 | 5.3e-13 | 13.51 | 10.2 | 1.6e-24 | 0.86 | 0.01 | 0.99 | FALSE |
10 | GTEx | Testis | CTPS1 | 0.57 | 0.28 | enet | 17 | 0.38 | 1.0e-17 | -6.17 | 9.2 | 4.9e-20 | 0.48 | 0.97 | 0.03 | FALSE |
11 | METSIM | Adipose | CTPS1 | 0.11 | 0.09 | enet | 31 | 0.09 | 6.2e-14 | -6.17 | 8.0 | 1.2e-15 | 0.27 | 1.00 | 0.00 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | CTPS1 | 0.04 | 0.04 | enet | 7 | 0.04 | 9.1e-06 | 11.27 | 8.6 | 7.6e-18 | 0.59 | 0.59 | 0.17 | TRUE |
13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLFNL1 | 0.03 | 0.01 | enet | 6 | 0.02 | 5.6e-05 | -0.70 | 7.3 | 3.8e-13 | 0.58 | 0.10 | 0.75 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | COL9A2 | 0.03 | 0.04 | lasso | 2 | 0.03 | 6.5e-04 | -5.37 | 5.4 | 7.7e-08 | -0.07 | 0.00 | 0.98 | TRUE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CTPS | 0.05 | 0.04 | blup | 49 | 0.03 | 1.0e-04 | -6.17 | 7.0 | 3.3e-12 | 0.33 | 0.13 | 0.07 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SCMH1 | 0.04 | 0.01 | enet | 7 | 0.02 | 2.5e-03 | -0.12 | -9.7 | 2.4e-22 | -0.70 | 0.01 | 0.84 | FALSE |
17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SCMH1 | 0.03 | 0.03 | lasso | 2 | 0.02 | 6.2e-03 | 13.95 | -13.9 | 3.3e-44 | -0.99 | 0.01 | 0.96 | FALSE |
18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SCMH1 | 0.35 | 0.14 | blup | 96 | 0.14 | 1.5e-05 | -7.04 | 8.9 | 4.8e-19 | 0.47 | 0.18 | 0.25 | FALSE |
19 | The Cancer Genome Atlas | Thyroid Carcinoma | SCMH1 | 0.07 | 0.08 | blup | 97 | 0.07 | 2.5e-07 | 13.18 | -15.6 | 8.3e-55 | -0.74 | 0.29 | 0.71 | TRUE |