TWAS hub - COL9A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.2062	0.0542	5.0e-07	0.155	NA	0.101	NA	0.141	3.7e-12	NA	2.7e-08	NA	3.8e-11
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0620	0.0320	5.3e-03	0.064	0.028	0.049	NA	0.044	1.6e-04	0.0096	8.2e-04	NA	1.5e-03
3	TCGA	Brain Lower Grade Glioma	0.0338	0.0165	2.6e-03	0.036	0.021	0.011	NA	0.025	5.3e-05	0.0016	1.7e-02	NA	6.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Birth weight of first child	7.7	14.0	21.4	4.5	4.6	0.4
Hand grip strength (right)	6.0	16.3	22.6	4.7	4.8	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	6.0	7.1	9.7	-3.1	-3.1	-1.4
Hand grip strength (left)	5.6	14.8	22.0	4.6	4.7	1.2
Medication: Seretide 50 evohaler	5.4	6.2	9.2	-3.0	-3.0	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.9	5.9	7.3	-2.6	-2.7	1.9
Peak expiratory flow (PEF)	4.8	11.1	15.1	3.7	3.9	2.1
Medication: Omeprazole	4.8	5.7	7.1	-2.7	-2.7	-1.7
Medication: Omeprazole (e.g. Zanprol)	4.8	5.9	8.3	-2.9	-2.9	-1.1
Height	4.4	85.2	182.2	6.0	6.1	13.5
Angina (self-reported)	4.1	5.4	6.8	-2.6	-2.6	-1.7
Angina	3.8	5.1	5.7	-2.4	-2.4	-2.0
High blood pressure (siblings)	3.7	5.3	6.8	-2.5	-2.6	-1.6
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	5.8	-2.4	-2.4	0.9
Standing height	3.5	34.8	64.5	4.4	4.5	8.0
Pulse rate, automated reading	3.5	11.3	16.9	4.1	4.1	-0.4
Ever used hormone-replacement therapy (HRT)	3.4	4.4	5.2	-2.3	-2.3	1.7
Forced vital capacity (FVC), Best measure	3.3	11.9	12.7	3.6	3.6	3.2
Exposure to tobacco smoke outside home	3.3	4.4	6.8	-2.5	-2.6	-0.2
Illnesses of father: High blood pressure	3.2	3.9	5.8	-2.3	-2.4	-0.7
Forced vital capacity (FVC)	2.8	10.8	14.1	3.0	3.0	3.8
Medication: Co-codamol	2.7	3.2	3.9	-1.9	-2.0	1.4
Illnesses of siblings	2.7	3.8	5.7	2.4	2.4	-0.5
Sitting height	2.6	18.2	30.1	3.4	3.6	5.5
Comparative height size at age 10	2.6	14.5	28.8	2.7	2.7	5.4
Back pain experienced in last month	2.6	3.8	5.2	-2.2	-2.3	-1.1
Heart attack/myocardial infarction (self-reported)	2.6	3.3	5.0	-2.1	-2.2	-0.7
Heart disease (siblings)	2.6	3.2	7.6	-1.0	-1.0	2.8
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	3.9	-1.9	-2.0	-0.8
Chest pain or discomfort	2.5	3.5	5.4	-2.3	-2.3	-0.2
Commuting to job workplace: Car/motor vehicle	2.5	2.9	4.3	-2.1	-2.1	0.2
Schizophrenia vs Biploar Disorder	2.4	3.2	3.7	1.9	1.9	-1.5
Diabetes (mother)	2.4	3.1	5.2	-1.5	-1.4	2.3
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	3.9	1.9	2.0	-0.2
Friendships satisfaction	2.4	2.9	4.0	2.0	1.9	1.0
Had menopause	2.3	2.9	4.7	-1.4	-1.4	2.2
Emphysema/chronic bronchitis	2.3	2.6	3.9	-1.9	-2.0	0.4
Lung FEV1/FVC ratio	2.2	11.3	14.1	-3.8	-3.6	-2.7
Number of treatments/medications taken	2.2	3.9	5.1	-2.3	-2.3	-1.3
Wheeze or whistling in the chest in last year	2.2	3.9	5.2	-2.2	-2.3	-1.3
Osteoporosis (self-reported)	2.2	2.7	4.1	-1.9	-2.0	0.4
Myopia	2.2	3.2	3.9	2.0	2.0	1.4
Crohns Disease (2012)	2.1	3.4	5.2	2.2	2.3	0.3
Heart attack	2.1	2.7	4.1	-1.9	-2.0	-0.6
Breastfed as a baby	2.1	2.6	4.0	2.0	2.0	-0.1
Qualifications: None of the above	2.0	4.3	6.6	-2.6	-2.5	-0.3
Happiness	2.0	2.5	3.8	2.0	1.9	-0.1
Heart disease (mother)	2.0	2.5	3.3	-1.8	-1.8	-1.0
Prostate Cancer	1.9	2.6	3.4	1.8	1.8	1.0
Triglycerides	1.9	3.1	4.7	-2.2	-2.1	0.5
Lung cancer (father)	1.9	2.2	3.2	-1.8	-1.8	-0.7
Exposure to tobacco smoke at home	1.9	2.1	2.3	-1.4	-1.5	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	3.0	4.1	-2.0	-2.0	-0.9
Leg fat percentage (right)	1.9	6.8	10.3	-3.1	-3.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.6	-1.8	-1.9	0.1
Risk taking	1.9	2.8	4.2	2.0	2.0	-0.2
Medication for hormone replacement therapy	1.8	2.0	2.6	-1.6	-1.5	-1.0
Number of full brothers	1.8	2.3	3.4	-1.8	-1.8	-0.1
Medication: Atenolol	1.7	2.1	3.2	-1.8	-1.8	0.2
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.3	-1.7	-1.8	-0.4
Forced expiratory volume in 1-second (FEV1)	1.7	5.9	6.1	2.4	2.4	2.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.6	4.0	2.0	1.9	0.4
HDL Cholesterol	1.6	2.7	3.1	1.7	1.8	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	2.5	1.6	1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	7.8	1.1	1.1	2.8
Tinnitus: Yes, now most or all of the time	1.6	1.9	2.4	1.6	1.5	-1.0
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.0	-1.4	-1.4	1.3
Pack years adult smoking proportion	1.5	2.3	6.2	-0.5	-0.6	-2.5
Current tobacco smoking	1.5	2.5	3.2	-1.7	-1.8	-1.1
Taking other prescription medications	1.5	2.3	3.5	-1.9	-1.9	-0.1
Waist circumference	1.5	5.4	9.0	-1.9	-1.9	3.0
Alcohol usually taken with meals	1.5	2.4	6.5	0.5	0.6	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	5.1	2.2	2.2	2.1
Comparative body size at age 10	1.5	4.0	6.2	-2.4	-2.5	-0.4
Mean time to correctly identify matches	1.5	2.9	3.9	-1.9	-2.0	-1.1
Illnesses of siblings: Diabetes	1.5	1.9	5.6	0.1	0.2	2.4
Stomach or abdominal pain in last month	1.4	1.8	5.4	0.1	0.1	-2.3
Mouth/teeth dental problems	1.4	2.2	3.0	1.6	1.7	1.0
Trunk fat-free mass	1.4	8.0	20.3	1.3	1.4	4.5
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.5	1.8	1.9	-0.1
Leg fat mass (right)	1.4	5.4	7.3	-2.6	-2.7	1.4
Arm fat percentage (left)	1.4	5.7	8.8	-2.9	-3.0	0.3
Average weekly red wine intake	1.4	2.1	3.2	1.8	1.8	-0.2
Medication: Atorvastatin	1.4	1.8	2.6	-1.5	-1.6	-0.6
Leg fat percentage (left)	1.4	5.0	7.5	-2.7	-2.7	0.7
Unable to work because of sickness or disability	1.4	1.8	2.0	-1.4	-1.4	-1.2
Reaction Time	1.3	2.6	3.7	-1.9	-1.9	-0.6
Allergy or Eczema	1.3	3.3	4.9	2.2	2.2	0.4
Pain all over the body in last month	1.3	1.4	3.8	-0.3	-0.3	2.0
Arm fat percentage (right)	1.3	4.9	7.7	-2.7	-2.8	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.4	0.3	0.3	2.1
Trunk predicted mass	1.3	7.7	19.4	1.3	1.4	4.4
Alcohol intake frequency.	1.3	3.1	4.0	-2.0	-2.0	1.1
Verbal and Numeric Reasoning (VNR)	1.2	2.9	7.2	-0.8	-0.9	2.7
Hayfever, allergic rhinitis or eczema	1.2	2.6	2.9	1.6	1.7	1.4
Body mass index (BMI)	1.2	5.2	8.0	-2.8	-2.8	-0.0
Pulse rate	1.2	2.0	2.9	1.7	1.6	0.7
Neck or shoulder pain in last month	1.2	1.7	2.4	-1.5	-1.6	-0.6
Medication: Blood pressure	1.2	2.2	2.9	-1.7	-1.7	-0.9
Pack years of smoking	1.2	1.7	4.1	-0.7	-0.8	-2.0
Age when periods started (menarche)	1.1	2.6	2.7	1.6	1.6	1.6
Nervous feelings	1.1	2.0	2.2	1.4	1.3	-1.5
Loud music exposure frequency	1.1	1.2	1.3	1.1	1.1	-1.0
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.9	-0.3	-0.4	-2.0
Number of self-reported non-cancer illnesses	1.1	2.0	3.0	-1.7	-1.7	-0.3
Pain type(s) experienced in last month: Hip pain	1.1	1.3	3.5	-0.5	-0.5	-1.9
Leg fat mass (left)	1.1	4.5	5.7	-2.3	-2.4	1.6
Diabetes (father)	1.0	1.2	1.6	-1.2	-1.2	0.8
Qualifications: CSEs or equivalent	1.0	1.4	4.0	0.3	0.2	-2.0
Chronic bronchitis/emphysema (father)	1.0	1.2	1.3	1.1	1.0	1.1
Allergy	1.0	2.3	4.0	-1.2	-1.2	-2.0
Weight	1.0	4.9	13.5	-0.8	-0.8	3.7
Mouth/teeth dental problems: Dentures	1.0	1.7	2.5	-1.5	-1.6	0.5
Medication: Cholesterol lowering	1.0	1.5	1.8	-1.2	-1.4	1.1
Depression (self-reported)	1.0	1.3	2.0	-1.3	-1.4	0.0
Medication: Amlodipine	1.0	1.4	2.0	-1.4	-1.4	-0.5
Body fat percentage	1.0	3.8	5.4	-2.2	-2.3	1.0
Arm fat-free mass (right)	1.0	5.3	15.6	0.4	0.4	4.0
Arm predicted mass (right)	1.0	5.1	14.8	0.5	0.5	3.9
Commuting to job workplace: Walk	1.0	1.1	1.6	1.2	1.3	-0.5
Commuting to job workplace: Public transport	1.0	1.2	1.3	1.1	1.1	1.1
Arm fat-free mass (left)	1.0	5.0	14.5	0.5	0.5	3.8
Commuting to job workplace: Cycle	1.0	1.2	1.6	1.3	1.3	-0.5
Arm predicted mass (left)	1.0	5.0	14.6	0.4	0.5	3.8
Lupus	0.9	1.4	1.6	1.2	1.2	1.1
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.9	-1.4	-1.2	0.1
Cardiovascular Disease	0.9	3.1	4.6	-2.1	-2.1	-0.6
Medication: Ramipril	0.9	1.2	1.8	-1.3	-1.4	-0.0
Hip circumference	0.9	3.7	10.4	-0.6	-0.6	3.2
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.7	-0.5	-0.4	-1.6
Glaucoma (self-reported)	0.9	1.0	1.6	-1.3	-1.2	-0.3
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.0	-0.2	-0.1	1.7
Whole body fat-free mass	0.9	5.3	14.4	0.9	0.9	3.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.1	-0.2	-0.2	-1.8
Whole body water mass	0.9	5.1	13.7	0.9	0.9	3.7
Medication: Paracetamol	0.9	1.4	4.0	-0.4	-0.4	-2.0
Basal metabolic rate	0.9	4.8	13.7	0.6	0.6	3.7
Age started oral contraceptive pill	0.9	1.1	3.2	0.1	0.2	1.8
Major Depression (MDD)	0.8	1.0	2.2	-0.5	-0.7	1.5
BMI	0.8	4.4	6.7	-2.5	-2.6	-0.1
Hypothyroidism (self reported)	0.8	1.8	2.7	-1.6	-1.6	0.3
Fed-up feelings	0.8	1.5	2.0	-1.4	-1.4	-0.7
Trunk fat mass	0.8	3.3	6.8	-1.2	-1.3	2.6
Number of incorrect matches in round	0.8	1.3	1.5	1.1	1.1	-1.2
Medication: Simvastatin	0.8	1.1	1.8	-1.2	-1.3	0.2
Arm fat mass (right)	0.8	3.2	4.1	-1.9	-2.0	1.3
Medication: Paracetamol	0.8	1.4	3.4	0.6	0.6	-1.9
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.3	-1.5	-1.5	0.7
Overall health rating	0.8	1.7	2.6	-1.6	-1.6	-0.0
Age at last live birth	0.8	1.2	3.6	0.1	0.1	-1.9
Medication: Aspirin	0.8	1.0	1.1	1.1	1.0	1.0
Eye problems/disorders: Cataract	0.8	0.9	2.7	0.2	0.2	1.6
Arm fat mass (left)	0.8	3.1	3.8	-1.9	-1.9	1.5
Ever smoked	0.8	1.5	1.5	1.2	1.2	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.2	3.2	1.7	1.8	0.7
Cholesterol lowering medication	0.8	1.2	1.7	-1.3	-1.3	-0.4
Mean Putamen Volume	0.7	0.8	1.2	-1.1	-1.1	-0.2
Rheumatoid Arthritis	0.7	1.0	2.1	0.7	0.6	1.5
Supplements: Zinc	0.7	0.8	1.2	1.1	1.1	0.0
Medication: Metformin	0.7	1.0	2.7	0.4	0.3	1.6
Trunk fat percentage	0.7	2.6	3.1	-1.7	-1.8	1.4
Average weekly fortified wine intake	0.7	0.8	1.3	1.1	1.1	-0.2
Maternal smoking around birth	0.7	1.1	1.2	-1.0	-1.1	1.0
Medication: Levothyroxine sodium	0.7	1.2	1.8	-1.3	-1.4	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.9	0.3	0.3	-1.7
Hair/balding pattern: Pattern 2	0.7	0.9	1.1	-1.0	-1.0	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.5	-1.1	-1.1	-1.6
Neuroticism score	0.7	1.5	3.5	-0.7	-0.8	-1.9
Blood clot in the leg (DVT)	0.7	0.9	2.1	0.6	0.6	1.4
Whole body fat mass	0.7	3.0	4.1	-1.5	-1.6	2.0
Loneliness, isolation	0.7	1.0	1.1	1.0	1.1	-1.0
Medication for cholesterol	0.7	1.0	1.6	1.2	1.2	-0.2
Medication: Aspirin	0.7	0.9	1.2	0.9	0.8	1.1
Smoking status: Current	0.7	1.1	1.5	-1.1	-1.2	-0.8
High cholesterol (Self-reported)	0.7	1.3	2.0	-1.3	-1.4	0.5
Medication: Bendroflumethiazide	0.7	1.1	1.1	-1.1	-1.0	-1.0
Ovarian Cancer	0.6	0.8	1.0	1.0	0.9	-0.7
Body Mass Index (BMI) (2010)	0.6	0.8	1.2	-1.0	-1.1	-0.3
Schizophrenia (2014)	0.6	1.2	2.8	0.6	0.7	-1.7
Systolic Blood Pressure	0.6	2.9	4.3	-1.9	-2.1	0.8
Smoking Status	0.6	1.5	2.3	-1.4	-1.5	-0.4
Relative age of first facial hair	0.6	1.2	1.6	1.2	1.3	-0.7
Severe depression (siblings)	0.6	0.6	1.6	-0.4	-0.4	1.3
High blood pressure	0.6	1.7	2.4	-1.5	-1.6	-0.6
Fluid intelligence score	0.6	1.3	2.0	-1.0	-1.0	1.4
Time employed in main current job	0.6	0.7	1.7	0.4	0.4	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.8	-0.8	-0.8	-1.3
Number of live births	0.6	0.9	1.0	-0.9	-0.9	1.0
Prospective memory result	0.6	0.7	2.1	0.2	0.2	1.4
Illnesses of mother	0.6	0.8	2.0	0.4	0.4	-1.4
Gout (self-reported)	0.6	0.8	1.8	-0.6	-0.5	1.3
Age at first live birth	0.6	1.0	1.4	1.2	1.2	-0.4
Shortness of breath walking on level ground	0.6	0.8	1.2	-1.0	-1.1	-0.2
Number of full sisters	0.6	0.7	1.0	-1.0	-1.0	0.2
Suffer from ‘nerves’	0.6	1.0	2.4	0.6	0.5	-1.6
Leg predicted mass (right)	0.6	3.0	7.7	0.8	0.8	2.8
Miserableness	0.6	1.0	1.1	-1.0	-1.0	-1.0
Basal cell carcinoma (self-reported)	0.6	0.7	0.9	-0.7	-0.8	1.0
Intelligence (Savage-Jansen 2018)	0.5	1.7	1.8	-1.4	-1.3	1.2
Worry (Nagel 2018)	0.5	1.0	3.0	0.2	0.2	-1.7
Heel T-Score	0.5	4.3	13.0	-0.2	-0.1	-3.6
Chronotype (morning person)	0.5	1.2	3.7	-0.1	-0.0	-1.9
Leg fat-free mass (left)	0.5	2.5	7.5	0.0	-0.0	2.7
Relative age voice broke	0.5	0.7	0.7	0.8	0.8	0.9
Impedance of leg (left)	0.5	2.3	2.9	1.7	1.7	1.1
Leg predicted mass (left)	0.5	2.5	7.5	0.1	0.1	2.7
Father’s age at death	0.5	0.6	0.9	0.7	0.7	-1.0
Pulse wave Arterial Stiffness index	0.5	0.5	1.5	0.3	0.4	1.2
Tense / ‘highly strung’	0.5	0.8	1.3	0.8	0.7	-1.1
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	0.9	1.0	1.4
Qualifications: College or University degree	0.5	1.5	2.3	1.5	1.5	0.2
Leg fat-free mass (right)	0.5	2.9	7.7	0.7	0.7	2.8
Qualifications: nursing, teaching	0.5	0.8	0.9	0.9	0.9	-0.7
Breast cancer (self-reported)	0.5	0.6	0.9	-0.9	-0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.3	-0.0	-0.0	-1.8
Financial situation satisfaction	0.5	0.6	1.0	-0.9	-1.0	-0.2
Medication: Blood pressure	0.5	1.0	1.1	-1.0	-1.1	0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.6	0.3	0.3	1.3
Ulcerative Colitis	0.4	0.6	0.8	0.8	0.9	-0.4
Waist Hip Ratio (WHR)	0.4	2.0	2.3	-1.5	-1.5	1.2
Lung FVC	0.4	2.3	3.4	1.8	1.8	-0.2
Neuroticism	0.4	0.9	2.2	-0.4	-0.5	-1.5
Systolic blood pressure, automated reading	0.4	1.0	1.5	-1.1	-1.2	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.0	-1.0	-1.0	-1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	0.8	0.8	-0.4
Had other major operations	0.4	0.5	1.1	0.4	0.4	1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.6	-0.1	-0.1	-1.3
Worrier / anxious feelings	0.4	0.7	2.1	-0.1	-0.2	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.7	0.5	0.6	0.9
Length of working week for main job	0.4	0.4	0.8	-0.5	-0.6	-0.9
Number of children fathered	0.4	0.4	0.6	-0.8	-0.7	0.5
Health satisfaction	0.4	0.5	1.2	-0.4	-0.4	1.1
Migraine (self-reported)	0.4	0.4	1.2	-0.3	-0.3	1.1
Supplements: Vitamin C	0.4	0.5	1.2	0.3	0.4	-1.1
Long-standing illness, disability or infirmity	0.4	0.5	0.8	-0.9	-0.9	0.3
Ever had bowel cancer screening	0.4	0.5	0.5	-0.7	-0.7	-0.7
Alcohol drinker status: Never	0.4	0.5	1.3	0.4	0.4	1.1
Breast Cancer	0.3	0.6	1.8	-0.2	-0.1	-1.3
LDL Cholesterol	0.3	0.5	0.7	0.6	0.6	0.8
Neuroticism (2016)	0.3	0.4	0.5	-0.6	-0.7	0.6
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.8	-0.7	-0.1
Blood Eosinophil Count	0.3	2.4	2.8	1.5	1.5	-1.7
Blood Platelet Count	0.3	4.0	5.7	2.4	2.2	-1.3
Blood Red Count	0.3	3.3	5.3	2.2	2.3	-0.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.1	-0.1	-1.1
Serious illness, injury or assault to yourself	0.3	0.3	0.4	-0.6	-0.6	0.5
High blood pressure (mother)	0.3	0.4	0.4	-0.6	-0.7	-0.5
Past tobacco smoking	0.3	0.5	0.6	-0.7	-0.7	-0.7
Alcohol intake versus 10 years previously	0.3	0.5	0.7	-0.9	-0.8	0.4
Birth weight	0.3	0.7	1.2	1.0	1.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.4	-0.6	-0.7	-0.4
Eye problems/disorders: None of the above	0.3	0.4	0.4	0.6	0.6	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	-0.3	-0.3	1.1
Medication: Allopurinol	0.3	0.3	0.5	0.7	0.7	0.0
Family relationship satisfaction	0.3	0.4	0.7	0.6	0.5	0.8
Leg pain on walking	0.3	0.3	1.0	-0.1	-0.1	1.0
Knee pain experienced in last month	0.3	0.5	1.2	-0.4	-0.3	-1.1
Hypertension (Self-reported)	0.3	0.9	1.4	-1.1	-1.2	-0.4
Illnesses of father: Heart disease	0.3	0.5	1.0	-0.5	-0.4	-1.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.5	0.6	0.4	-0.7
Mood swings	0.3	0.5	1.3	-0.3	-0.3	-1.1
Ever taken oral contraceptive pill	0.3	0.4	0.4	-0.6	-0.7	-0.5
Medication: Lisinopril	0.3	0.3	0.4	-0.6	-0.6	0.5
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.6	-0.8	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	0.6	0.6	-0.6
Depressed Affect (Nagel 2018)	0.2	0.5	1.4	-0.1	-0.0	-1.2
Depression (Nagel 2018)	0.2	0.2	0.6	-0.1	-0.2	-0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	0.4	0.4	0.5
Crohns Disease (2017)	0.2	0.4	1.3	0.0	0.1	-1.1
Bipolar Disorder (2011)	0.2	0.2	0.7	0.8	0.0	0.0
Fasting Glucose	0.2	0.3	0.3	-0.4	-0.5	-0.6
Hair Pigment	0.2	5.5	6.4	-2.2	-2.3	2.5
Sensitivity / hurt feelings	0.2	0.3	0.5	0.7	0.7	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.4	0.4	-0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.2	-0.5	-0.5	-0.3
Townsend deprivation index at recruitment	0.2	0.2	0.4	0.6	0.5	0.2
Multivitamins +/- minerals	0.2	0.2	0.4	-0.4	-0.3	0.7
Hearing difficulty/problems with background noise	0.2	0.3	0.3	0.5	0.6	-0.5
Diabetes (self-reported)	0.2	0.3	0.4	0.7	0.6	0.2
Falls in the last year	0.2	0.3	0.5	-0.7	-0.7	0.1
Medication: Lansoprazole	0.2	0.2	0.4	-0.6	-0.6	0.2
Pulse wave reflection index	0.2	0.3	0.4	-0.6	-0.6	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.2	-0.2	-0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	-0.2	-0.3	0.8
Had major operations	0.2	0.2	0.3	0.6	0.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	0.1	0.1	-0.9
Medication: Gliclazide	0.2	0.2	0.2	0.4	0.4	0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.3	-0.5	-0.5	0.5
Hearing aid user	0.2	0.2	0.6	0.2	0.2	-0.8
Mother’s age at death	0.2	0.2	0.4	0.6	0.6	0.2
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.6	-0.5	-0.3
Diastolic blood pressure, automated reading	0.2	0.5	0.7	0.9	0.8	0.1
Supplements: Calcium	0.2	0.2	0.3	-0.5	-0.6	-0.2
Impedance of whole body	0.2	1.1	1.5	1.2	1.2	0.5
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.5	-0.6	0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.4	-0.6	-0.6	-0.2
Neuroticism (Nagel 2018)	0.1	0.3	1.0	-0.1	-0.1	-1.0
Schizophrenia (2018)	0.1	0.1	0.2	-0.3	-0.3	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.1	-0.2	0.5
Alzheimer’s Disease (including proxy)	0.1	0.2	0.2	0.4	0.3	0.5
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.5	0.6	0.2
Age at First Birth	0.1	0.1	0.2	-0.5	-0.3	0.0
HbA1C	0.1	0.1	0.2	0.3	0.4	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	0.3	0.2	0.4
Tanning	0.1	0.8	1.3	1.1	1.1	0.1
Average weekly spirits intake	0.1	0.1	0.2	-0.1	-0.2	-0.4
Vitamin and mineral supplements	0.1	0.2	0.2	0.5	0.4	0.4
Impedance of leg (right)	0.1	0.6	0.9	0.6	0.6	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	-0.2	-0.2	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.3	0.3	-0.5
Supplements: Glucosamine	0.1	0.1	0.2	0.3	0.3	0.4
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.1	-0.1	-0.7
Impedance of arm (right)	0.1	0.3	0.5	0.7	0.7	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.2	0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.2	0.5	0.5	0.1
Asthma	0.1	0.2	0.6	-0.3	-0.2	0.8
Impedance of arm (left)	0.1	0.3	0.5	0.7	0.7	0.1
Headache pain in last month	0.1	0.1	0.3	-0.2	-0.2	-0.5
Worry too long after embarrassment	0.1	0.2	0.3	-0.4	-0.4	-0.6
Pulse wave peak to peak time	0.1	0.1	0.3	0.2	0.1	-0.6
Smoking status: Previous	0.1	0.1	0.2	0.2	0.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.5	0.5	0.1
Mineral and other dietary supplements	0.1	0.2	0.2	-0.5	-0.4	-0.3
Asthma (self-reported)	0.1	0.1	0.3	-0.2	-0.2	0.5
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.2	-0.2	0.6
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	0.3	0.3	-0.0
Guilty feelings	0.1	0.2	0.5	-0.2	-0.2	-0.7
Number of operations (self-reported)	0.1	0.2	0.5	-0.0	-0.1	0.7
Irritability	0.1	0.2	0.2	-0.4	-0.5	0.3
Pain experienced in last month	0.1	0.2	0.5	0.2	0.1	0.7
Alcohol drinker status: Previous	0.1	0.2	0.5	-0.1	-0.1	0.7
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.1	0.1	-0.5
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.1	0.1	-0.2
Blood White Count	0.0	0.1	0.2	0.4	0.3	0.4
Respiratory disease	0.0	0.1	0.1	0.2	0.2	-0.3
Noisy workplace	0.0	0.0	0.1	0.0	-0.0	0.2
Medication: Ibuprofen	0.0	0.0	0.1	-0.1	0.0	0.3
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.1	-0.0	0.1
Wears glasses or contact lenses	0.0	0.0	0.0	-0.1	-0.2	0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.2	0.2	-0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.0	-0.1	-0.1	-0.1
Ever depressed for a whole week	0.0	0.0	0.0	-0.0	-0.1	0.2

Hub : Genes

COL9A2

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Trait associations