Best TWAS P=8.95e-10 · Best GWAS P=2.06e-10 conditioned to 4.54e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Cells Transformed fibroblasts | DSE | 0.07 | 0.01 | enet | 7 | 0.01 | 4.1e-02 | -5.1 | -6.1 | 9.0e-10 | -0.58 | 0.33 | 0.46 | TRUE |
| 1 | CommonMind | Brain Pre-frontal Cortex | GOPC | 0.12 | 0.11 | lasso | 7 | 0.09 | 2.2e-11 | 5.9 | 5.9 | 4.0e-09 | -0.08 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Cells Transformed fibroblasts | RP1-93H18.7 | 0.08 | 0.06 | enet | 8 | 0.07 | 3.9e-06 | -4.9 | -5.9 | 4.3e-09 | -0.65 | 0.54 | 0.44 | FALSE |
| 3 | GTEx | Artery Tibial | GOPC | 0.11 | 0.08 | lasso | 4 | 0.09 | 9.0e-08 | 6.2 | -5.9 | 4.4e-09 | 0.10 | 0.01 | 0.99 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | GOPC | 0.13 | 0.16 | enet | 21 | 0.16 | 1.5e-19 | 6.0 | 5.9 | 4.6e-09 | -0.09 | 0.01 | 0.99 | FALSE |
| 6 | NTR | Blood | DSE | 0.04 | 0.02 | bslmm | 437 | 0.02 | 1.7e-08 | -5.1 | -5.3 | 1.1e-07 | -0.62 | 0.02 | 0.98 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | DSE | 0.05 | 0.01 | blup | 112 | 0.04 | 1.6e-04 | -2.3 | -5.3 | 1.1e-07 | -0.60 | 0.02 | 0.45 | FALSE |
| 2 | GTEx | Artery Aorta | NT5DC1 | 0.23 | 0.08 | lasso | 10 | 0.08 | 4.6e-05 | 3.7 | 5.2 | 2.2e-07 | 0.34 | 0.83 | 0.04 | FALSE |