Best TWAS P=1.01e-11 · Best GWAS P=7.92e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | PSMA4 | 0.18 | 0.14 | lasso | 1 | 0.11 | 6.5e-04 | -6.8 | -6.8 | 1.0e-11 | 0.97 | 0.01 | 0.95 | TRUE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA3 | 0.24 | 0.15 | enet | 5 | 0.16 | 6.5e-06 | -6.8 | 6.6 | 3.1e-11 | -0.93 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA5 | 0.17 | 0.15 | lasso | 4 | 0.14 | 3.1e-05 | -6.8 | 6.6 | 3.9e-11 | -0.97 | 0.00 | 0.98 | FALSE |
| 4 | YFS | Blood | PSMA4 | 0.08 | 0.08 | lasso | 10 | 0.11 | 8.3e-35 | -6.5 | -6.5 | 6.5e-11 | 0.82 | 0.04 | 0.96 | FALSE |
| 3 | YFS | Blood | IREB2 | 0.18 | 0.20 | enet | 28 | 0.24 | 4.0e-78 | -6.2 | 6.2 | 6.5e-10 | -0.71 | 0.14 | 0.86 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CHRNA5 | 0.15 | 0.07 | blup | 50 | 0.09 | 2.5e-04 | 4.5 | 5.9 | 4.7e-09 | -0.66 | 0.19 | 0.52 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSMA4 | 0.08 | 0.02 | blup | 40 | 0.03 | 1.1e-02 | 5.2 | 5.4 | 5.5e-08 | -0.50 | 0.05 | 0.17 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHRNA3 | 0.05 | 0.02 | blup | 44 | 0.02 | 7.6e-03 | -6.8 | 5.4 | 7.6e-08 | -0.92 | 0.00 | 0.97 | FALSE |
| 2 | GTEx | Testis | CHRNA5 | 0.16 | 0.07 | enet | 11 | 0.11 | 1.4e-05 | -6.8 | -5.3 | 9.2e-08 | 0.86 | 0.01 | 0.99 | FALSE |