Hub : Traits :

Father's age at death

17 significantly associated models · 9 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 12 111154626 112582540 1 1 3.0e-08 1.1e-05 0.28 94 SH2B3
2 15 40085637 41752852 3 1 2.6e-08 1.2e-07 0.26 95 GCHFR
3 15 78032707 79573404 4 1 1.0e-11 7.9e-12 1.00 100 PSMA4
4 15 90730363 92135418 1 1 1.2e-07 5.0e-07 0.54 98 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 3.12 1 0 0.0 0.00 1.00 FES
Bipolar Disorder or Schizophrenia 9.44 2 1 2.2 0.00 1.00 FES PSMA4
Depressed Affect (Nagel 2018) 3.41 1 0 0.0 0.00 1.00 SH2B3
Neuroticism (Nagel 2018) 2.10 1 0 0.0 0.00 1.00 FES
Schizophrenia (2018) 9.95 2 1 2.2 0.00 1.00 FES PSMA4
Crohns Disease (2017) 2.04 1 0 0.0 0.00 1.00 FES
Irritable Bowel Disease (IBD) 2.48 2 0 0.0 0.00 1.00 FES SH2B3
Reaction Time 8.52 1 1 2.2 0.00 1.00 SH2B3
Breast Cancer 5.09 2 0 0.0 0.00 1.00 FES GCHFR
Ovarian Cancer 2.65 1 0 0.0 0.00 1.00 FES
Prostate Cancer 5.73 1 0 0.0 0.00 1.00 GCHFR
Body Mass Index (BMI) (2010) 2.75 1 0 0.0 0.00 1.00 SH2B3
Coronary Artery Disease (CAD) 4.85 1 0 0.0 0.00 1.00 SH2B3
Crohns Disease (2012) 2.31 1 0 0.0 0.00 1.00 FES
LDL Cholesterol 4.57 1 0 0.0 0.00 1.00 SH2B3
Lupus 3.84 1 0 0.0 0.00 1.00 SH2B3
Primary Biliary Cirrhosis 5.55 1 1 2.2 0.00 1.00 SH2B3
Rheumatoid Arthritis 4.41 1 0 0.0 0.00 1.00 SH2B3
Schizophrenia (2014) 8.41 2 1 2.2 0.00 1.00 FES PSMA4
Blood Eosinophil Count 45.01 1 1 2.2 0.00 1.00 SH2B3
Blood Platelet Count 6.53 1 1 2.2 0.00 1.00 SH2B3
Blood Red Count 7.22 3 1 2.2 0.00 1.00 FES PSMA4 SH2B3
Blood White Count 20.99 2 2 4.4 0.00 1.00 FES SH2B3
Height 0.98 2 2 4.4 0.00 1.00 FES SH2B3
Waist Hip Ratio (WHR) 1.55 1 0 0.0 0.00 1.00 GCHFR
Systolic Blood Pressure 26.78 3 2 4.4 0.00 1.00 FES GCHFR SH2B3
Smoking Status 4.95 2 0 0.0 0.00 1.00 FES GCHFR
Allergy or Eczema 4.57 3 0 0.0 0.00 1.00 FES PSMA4 SH2B3
Cardiovascular Disease 20.08 2 2 4.4 0.00 1.00 FES SH2B3
Hypothyroidism (self reported) 29.53 2 1 2.2 0.00 1.00 GCHFR SH2B3
Respiratory disease 2.77 1 0 0.0 0.00 1.00 FES
Type 2 Diabetes (T2D) (2018) 2.80 1 0 0.0 0.00 1.00 SH2B3
Lung FEV1/FVC ratio 2.17 1 1 2.2 0.00 1.00 PSMA4
Lung FVC 3.04 2 1 2.2 0.00 1.00 PSMA4 SH2B3
Neuroticism 2.22 1 0 0.0 0.00 1.00 FES
Hair Pigment 0.77 2 2 4.4 0.00 1.00 FES SH2B3
Tanning 0.48 1 0 0.0 0.00 1.00 SH2B3
Hand grip strength (left) 2.06 1 0 0.0 0.00 1.00 FES
Number of treatments/medications taken 8.46 2 1 2.2 0.00 1.00 FES SH2B3
Sensitivity / hurt feelings 4.14 1 1 2.2 0.00 1.00 FES
Systolic blood pressure, automated reading 20.80 2 2 4.4 0.00 1.00 FES SH2B3
Angina 12.98 2 1 2.2 0.00 1.00 FES PSMA4
Vitamin and mineral supplements 2.92 1 0 0.0 0.00 1.00 PSMA4
Severe depression (siblings) 2.95 1 0 0.0 0.00 1.00 FES
Pack years adult smoking proportion 56.76 2 1 2.2 0.00 1.00 GCHFR PSMA4
Impedance of leg (right) 1.80 1 1 2.2 0.00 1.00 FES
Leg fat-free mass (left) 1.66 2 0 0.0 0.00 1.00 FES SH2B3
Townsend deprivation index at recruitment 2.33 1 0 0.0 0.00 1.00 GCHFR
Current tobacco smoking 4.12 1 0 0.0 0.00 1.00 FES
Maternal smoking around birth 2.94 1 0 0.0 0.00 1.00 PSMA4
Fed-up feelings 5.17 1 1 2.2 0.00 1.00 SH2B3
Frequency of unenthusiasm / disinterest in last 2 weeks 3.11 1 0 0.0 0.00 1.00 SH2B3
Taking other prescription medications 8.16 2 1 2.2 0.00 1.00 GCHFR SH2B3
Age when periods started (menarche) 1.47 1 0 0.0 0.00 1.00 PSMA4
Bilateral oophorectomy (both ovaries removed) 2.56 1 0 0.0 0.00 1.00 PSMA4
High blood pressure 23.77 2 2 4.4 0.00 1.00 FES SH2B3
Hayfever, allergic rhinitis or eczema 3.98 2 0 0.0 0.00 1.00 FES SH2B3
Multivitamins +/- minerals 3.53 1 0 0.0 0.00 1.00 PSMA4
Medication: Atenolol 16.59 2 2 4.4 0.00 1.00 FES SH2B3
Medication: Levothyroxine sodium 23.74 1 1 2.2 0.00 1.00 SH2B3
Sitting height 0.78 1 0 0.0 0.00 1.00 FES
Chronic bronchitis/emphysema (father) 12.57 1 1 2.2 0.00 1.00 PSMA4
High blood pressure (mother) 19.06 2 1 2.2 0.00 1.00 FES SH2B3
Impedance of leg (left) 1.75 1 1 2.2 0.00 1.00 FES
Leg predicted mass (left) 1.61 2 0 0.0 0.00 1.00 FES SH2B3
Number of incorrect matches in round 4.22 1 0 0.0 0.00 1.00 FES
Past tobacco smoking 7.28 3 0 0.0 0.00 1.00 FES GCHFR SH2B3
Alcohol usually taken with meals 3.64 1 0 0.0 0.00 1.00 FES
Forced vital capacity (FVC) 1.92 1 1 2.2 0.00 1.00 PSMA4
Heart attack 9.53 2 1 2.2 0.00 1.00 FES SH2B3
Allergy 4.29 2 0 0.0 0.00 1.00 FES GCHFR
Medication: Ramipril 7.18 2 0 0.0 0.00 1.00 FES SH2B3
Medication: Simvastatin 6.75 1 1 2.2 0.00 1.00 FES
Illnesses of siblings 11.53 3 1 2.2 0.00 1.00 FES GCHFR SH2B3
Weight 1.34 1 0 0.0 0.00 1.00 SH2B3
Impedance of arm (right) 0.82 1 0 0.0 0.00 1.00 SH2B3
Trunk fat-free mass 2.33 2 1 2.2 0.00 1.00 FES SH2B3
Hip circumference 1.44 1 0 0.0 0.00 1.00 SH2B3
Frequency of tiredness / lethargy in last 2 weeks 2.77 1 0 0.0 0.00 1.00 SH2B3
Number of live births 4.61 2 0 0.0 0.00 1.00 FES GCHFR
Forced expiratory volume in 1-second (FEV1) 3.58 1 1 2.2 0.00 1.00 PSMA4
Pulse rate 1.61 1 0 0.0 0.00 1.00 SH2B3
Mouth/teeth dental problems: Dentures 4.06 1 0 0.0 0.00 1.00 PSMA4
Asthma 2.54 1 0 0.0 0.00 1.00 FES
Medication: Cholesterol lowering 8.13 2 1 2.2 0.00 1.00 FES SH2B3
Medication: Lansoprazole 3.82 1 0 0.0 0.00 1.00 SH2B3
Lung cancer (father) 15.80 2 1 2.2 0.00 1.00 FES PSMA4
Illnesses of mother 12.29 2 1 2.2 0.00 1.00 FES SH2B3
Forced expiratory volume in 1-second (FEV1), Best measure 4.11 1 1 2.2 0.00 1.00 PSMA4
Pulse wave Arterial Stiffness index 4.86 2 0 0.0 0.00 1.00 FES SH2B3
Impedance of arm (left) 1.13 1 0 0.0 0.00 1.00 SH2B3
Trunk predicted mass 2.34 2 1 2.2 0.00 1.00 FES SH2B3
Standing height 1.02 1 1 2.2 0.00 1.00 SH2B3
Breastfed as a baby 3.21 1 0 0.0 0.00 1.00 FES
Hair/balding pattern: Pattern 4 2.19 1 0 0.0 0.00 1.00 FES
Birth weight of first child 16.12 2 2 4.4 0.00 1.00 FES SH2B3
Peak expiratory flow (PEF) 1.37 1 0 0.0 0.00 1.00 PSMA4
Blood clot in the leg (DVT) 3.49 1 0 0.0 0.00 1.00 SH2B3
Headache pain in last month 3.78 1 0 0.0 0.00 1.00 FES
Medication for cholesterol, blood pressure or diabetes 17.01 2 2 4.4 0.00 1.00 FES SH2B3
Gout (self-reported) 3.89 1 0 0.0 0.00 1.00 SH2B3
Hypothyroidism/myxoedema (self-reported) 23.99 1 1 2.2 0.00 1.00 SH2B3
Medication: Amlodipine 8.00 1 1 2.2 0.00 1.00 FES
Birth weight 9.19 2 2 4.4 0.00 1.00 FES SH2B3
Chronic bronchitis/emphysema (mother) 10.67 1 1 2.2 0.00 1.00 PSMA4
High blood pressure (siblings) 12.12 3 1 2.2 0.00 1.00 FES GCHFR SH2B3
Forced vital capacity (FVC), Best measure 2.18 1 1 2.2 0.00 1.00 PSMA4
Arm fat-free mass (right) 2.09 1 1 2.2 0.00 1.00 SH2B3
Exposure to tobacco smoke outside home 4.74 2 0 0.0 0.00 1.00 GCHFR SH2B3
Wheeze or whistling in the chest in last year 3.86 2 0 0.0 0.00 1.00 GCHFR PSMA4
Reason for reducing amount of alcohol drunk: Health precaution 3.20 1 0 0.0 0.00 1.00 GCHFR
Pulse wave peak to peak time 5.05 2 0 0.0 0.00 1.00 FES SH2B3
Qualifications: College or University degree 1.00 1 0 0.0 0.00 1.00 GCHFR
Emphysema/chronic bronchitis 3.27 1 0 0.0 0.00 1.00 PSMA4
Neck or shoulder pain in last month 2.23 1 0 0.0 0.00 1.00 GCHFR
Medication: Blood pressure 20.29 2 2 4.4 0.00 1.00 FES SH2B3
Angina (self-reported) 13.13 2 1 2.2 0.00 1.00 FES PSMA4
Medication: Allopurinol 3.31 1 0 0.0 0.00 1.00 SH2B3
Mean time to correctly identify matches 9.17 2 1 2.2 0.00 1.00 FES SH2B3
Heart disease (mother) 5.65 1 0 0.0 0.00 1.00 FES
Arm predicted mass (right) 2.13 1 1 2.2 0.00 1.00 SH2B3
Comparative height size at age 10 2.78 2 1 2.2 0.00 1.00 FES SH2B3
Overall health rating 3.81 2 0 0.0 0.00 1.00 GCHFR PSMA4
Chest pain or discomfort 2.96 1 0 0.0 0.00 1.00 GCHFR
Qualifications: NVQ or HND or HNC or equivalent 2.69 1 0 0.0 0.00 1.00 SH2B3
Illness, injury, bereavement, stress in last 2 years 2.20 1 0 0.0 0.00 1.00 GCHFR
Medication: Aspirin 9.45 2 1 2.2 0.00 1.00 FES SH2B3
Knee pain experienced in last month 3.58 1 0 0.0 0.00 1.00 PSMA4
Hypertension (Self-reported) 23.41 2 2 4.4 0.00 1.00 FES SH2B3
Illnesses of father: Heart disease 13.60 2 1 2.2 0.00 1.00 FES SH2B3
Smoking status: Previous 8.55 2 0 0.0 0.00 1.00 PSMA4 SH2B3
Whole body fat-free mass 2.05 2 1 2.2 0.00 1.00 FES SH2B3
Leg fat-free mass (right) 1.79 2 0 0.0 0.00 1.00 FES SH2B3
Handedness (chirality/laterality): Left-handed 3.44 1 0 0.0 0.00 1.00 FES
Mood swings 3.37 1 0 0.0 0.00 1.00 SH2B3
Loneliness, isolation 4.38 1 0 0.0 0.00 1.00 SH2B3
Long-standing illness, disability or infirmity 4.52 2 0 0.0 0.00 1.00 GCHFR SH2B3
Diabetes diagnosed by doctor 2.91 1 0 0.0 0.00 1.00 SH2B3
Qualifications: nursing, teaching 2.06 1 0 0.0 0.00 1.00 SH2B3
Mouth/teeth dental problems: Mouth ulcers 3.55 1 0 0.0 0.00 1.00 SH2B3
Medication for cholesterol 9.07 2 1 2.2 0.00 1.00 FES SH2B3
Back pain experienced in last month 3.11 1 0 0.0 0.00 1.00 SH2B3
Mineral and other dietary supplements 2.79 1 0 0.0 0.00 1.00 FES
Asthma (self-reported) 2.54 1 0 0.0 0.00 1.00 FES
Medication: Aspirin 9.28 2 1 2.2 0.00 1.00 FES SH2B3
Illnesses of father: None of the above (group 1) 13.43 2 1 2.2 0.00 1.00 FES SH2B3
Smoking status: Current 3.65 1 0 0.0 0.00 1.00 FES
Forced expiratory volume in 1-second (FEV1), predicted percentage 8.50 1 1 2.2 0.00 1.00 PSMA4
Whole body water mass 2.12 2 1 2.2 0.00 1.00 FES SH2B3
Leg predicted mass (right) 1.82 2 0 0.0 0.00 1.00 FES SH2B3
Number of self-reported non-cancer illnesses 7.01 1 1 2.2 0.00 1.00 SH2B3
Mother's age at death 6.46 2 0 0.0 0.00 1.00 PSMA4 SH2B3
Medication: Blood pressure 18.58 2 2 4.4 0.00 1.00 FES SH2B3
Supplements: Fish oil (including cod liver oil) 2.12 1 0 0.0 0.00 1.00 FES
High cholesterol (Self-reported) 2.87 1 0 0.0 0.00 1.00 FES
Medication: Bendroflumethiazide 8.37 2 1 2.2 0.00 1.00 FES SH2B3
Medication: Lisinopril 5.42 2 0 0.0 0.00 1.00 FES SH2B3
Illnesses of father: High blood pressure 14.71 2 1 2.2 0.00 1.00 FES SH2B3
Ever smoked 9.20 4 0 0.0 0.41 0.59 FES GCHFR PSMA4 SH2B3
Basal metabolic rate 1.98 2 1 2.2 0.00 1.00 FES SH2B3
Arm fat-free mass (left) 2.47 1 1 2.2 0.00 1.00 SH2B3
Risk taking 9.65 3 0 0.0 0.00 1.00 FES GCHFR PSMA4
Age started oral contraceptive pill 2.48 1 0 0.0 0.00 1.00 FES
Diastolic blood pressure, automated reading 24.79 2 2 4.4 0.00 1.00 FES SH2B3
Vascular/heart problems diagnosed by doctor 26.36 2 2 4.4 0.00 1.00 FES SH2B3
Pain experienced in last month 5.85 2 0 0.0 0.00 1.00 PSMA4 SH2B3
Heart attack/myocardial infarction (self-reported) 10.05 2 1 2.2 0.00 1.00 FES SH2B3
Deep venous thrombosis (DVT) (self-reported) 3.24 1 0 0.0 0.00 1.00 SH2B3
Heart disease (siblings) 6.93 1 0 0.0 0.00 1.00 FES
Pack years of smoking 52.09 2 1 2.2 0.00 1.00 GCHFR PSMA4
Impedance of whole body 0.97 2 0 0.0 0.00 1.00 FES SH2B3
Arm predicted mass (left) 2.35 1 1 2.2 0.00 1.00 SH2B3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.5
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 0 0.000 1.4
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 0 0.000 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.5
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 1 0.139 1.4
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.4
GTEx Testis 1 0.032 1.4
GTEx Thyroid 1 0.025 1.4
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.4
YFS Blood 4 0.087 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3