[Hub]/) : Traits : Hypertension (Self-reported) :

chr1:10,435,170-12,600,396

Best TWAS P=1.72e-28 · Best GWAS P=3.73e-30 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial CLCN6 0.14 0.04 lasso 6 0.04 5.0e-04 -7.107 -5.5 3.0e-08 -0.06 0.10 0.89 FALSE
2 GTEx Breast Mammary Tissue NPPA-AS1 0.25 0.01 lasso 4 0.02 3.0e-02 4.189 5.2 1.6e-07 0.08 0.46 0.05 TRUE
3 GTEx Breast Mammary Tissue (Female) NPPA-AS1 0.16 0.01 lasso 3 0.00 3.4e-01 4.189 5.2 1.7e-07 0.08 0.07 0.11 FALSE
4 GTEx Cells EBV-transformed lymphocytes MTHFR 0.33 0.12 lasso 6 0.09 7.9e-04 -6.905 -6.9 5.0e-12 -0.07 0.33 0.29 FALSE
5 GTEx Cells Transformed fibroblasts CLCN6 0.08 0.02 enet 17 0.05 1.6e-04 -11.051 -8.6 5.5e-18 -0.12 0.01 0.99 FALSE
6 GTEx Cells Transformed fibroblasts MTHFR 0.13 0.03 enet 30 0.05 6.8e-05 -8.014 -8.3 6.6e-17 -0.05 0.04 0.93 TRUE
7 GTEx Skin Not Sun Exposed Suprapubic CLCN6 0.12 0.03 lasso 3 0.04 3.3e-03 -5.714 -9.1 1.0e-19 -0.05 0.02 0.94 FALSE
8 GTEx Skin Sun Exposed Lower leg CLCN6 0.08 0.00 lasso 3 0.01 7.9e-02 -4.389 -6.9 4.4e-12 -0.08 0.03 0.72 FALSE
9 GTEx Spleen CLCN6 0.21 0.10 lasso 3 0.06 1.3e-02 -6.914 -8.2 2.8e-16 -0.07 0.04 0.72 TRUE
10 GTEx Stomach RP4-635E18.7 0.13 0.06 enet 25 0.03 8.8e-03 -1.163 -5.3 1.0e-07 -0.44 0.12 0.58 TRUE
11 GTEx Testis NPPA 0.36 0.23 lasso 9 0.24 5.0e-11 -3.467 5.4 7.3e-08 0.05 1.00 0.00 FALSE
12 METSIM Adipose CLCN6 0.09 0.04 blup 480 0.06 1.6e-09 -6.244 -7.6 2.7e-14 -0.10 0.06 0.94 FALSE
13 METSIM Adipose DRAXIN 0.09 0.01 enet 21 0.04 1.6e-06 -0.079 5.6 2.5e-08 -0.05 0.03 0.92 FALSE
14 NTR Blood AGTRAP 0.02 0.00 bslmm 484 0.00 5.2e-02 0.578 6.2 7.4e-10 0.08 0.05 0.06 FALSE
15 NTR Blood CLCN6 0.01 0.01 lasso 2 0.01 3.0e-04 -7.107 -5.8 8.0e-09 -0.05 0.38 0.54 FALSE
16 NTR Blood MTHFR 0.09 0.07 enet 17 0.10 4.4e-31 -4.210 -7.4 1.3e-13 -0.07 1.00 0.00 TRUE
17 ROSMAP Brain Pre-frontal Cortex C1orf167 0.07 0.01 blup 475 0.03 1.4e-04 -6.350 -5.9 3.4e-09 -0.03 0.36 0.04 FALSE
18 ROSMAP Brain Pre-frontal Cortex NPPA-AS1 0.38 0.41 lasso 12 0.50 4.6e-73 -3.458 5.6 2.5e-08 0.06 1.00 0.00 TRUE
19 YFS Blood MTHFR 0.50 0.49 enet 40 0.62 5.5e-264 -4.210 -6.0 2.7e-09 -0.06 1.00 0.00 FALSE
20 The Cancer Genome Atlas Breast Invasive Carcinoma CLCN6 0.06 0.06 blup 104 0.06 5.0e-12 -8.198 -11.1 1.7e-28 -0.09 0.22 0.78 TRUE
21 The Cancer Genome Atlas Colon Adenocarcinoma CLCN6 0.14 0.05 blup 104 0.09 1.2e-05 -10.766 -7.7 1.2e-14 -0.04 0.01 0.98 FALSE
22 The Cancer Genome Atlas Colon Adenocarcinoma MTHFR 0.07 0.01 blup 92 0.04 2.9e-03 -0.572 -7.1 1.2e-12 -0.07 0.04 0.47 FALSE
23 The Cancer Genome Atlas Colon Adenocarcinoma NPPA 0.06 0.01 lasso 5 0.01 1.3e-01 -3.710 6.2 6.9e-10 0.06 0.04 0.24 FALSE
24 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CLCN6 0.04 0.06 lasso 2 0.05 1.1e-06 -8.198 -9.2 2.2e-20 -0.08 0.10 0.89 FALSE
25 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CLCN6 0.05 0.05 lasso 6 0.05 9.2e-07 -4.389 -7.3 2.5e-13 -0.07 0.50 0.47 FALSE
26 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CLCN6 0.07 0.00 blup 104 0.03 7.9e-03 3.698 -7.4 1.2e-13 -0.09 0.06 0.28 FALSE
27 The Cancer Genome Atlas Lung Adenocarcinoma CLCN6 0.06 0.04 blup 104 0.04 5.2e-06 -11.051 -10.7 8.9e-27 -0.07 0.01 0.99 TRUE
28 The Cancer Genome Atlas Prostate Adenocarcinoma CLCN6 0.10 0.07 blup 104 0.07 3.9e-08 -8.228 -10.3 4.5e-25 -0.06 0.20 0.80 FALSE
29 The Cancer Genome Atlas Stomach Adenocarcinoma CLCN6 0.07 0.04 blup 104 0.05 2.4e-04 -10.766 -10.0 1.2e-23 -0.09 0.01 0.98 FALSE
30 The Cancer Genome Atlas Stomach Adenocarcinoma NPPA 0.06 0.03 enet 4 0.04 7.6e-04 -8.228 6.8 9.9e-12 0.05 0.11 0.15 TRUE
31 The Cancer Genome Atlas Thyroid Carcinoma CLCN6 0.08 0.02 blup 104 0.05 2.5e-05 -6.350 -8.2 1.6e-16 -0.06 0.15 0.84 FALSE