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chr16:89,013,848-90,172,696

Best TWAS P=2e-14 · Best GWAS P=3.76e-14 conditioned to 0.298

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C16orf55	0.06	0.02	lasso	3	0.02	6.2e-04	6.9	-6.6	3.5e-11	0.76	0.07	0.92	FALSE
2	GTEx	Adipose Subcutaneous	DEF8	0.11	0.02	enet	16	0.06	1.3e-05	5.4	5.2	2.1e-07	-0.43	0.16	0.52	FALSE
3	GTEx	Adipose Subcutaneous	SPATA33	0.17	0.12	lasso	6	0.12	5.6e-10	-7.0	-7.2	8.7e-13	0.96	0.02	0.98	FALSE
4	GTEx	Adipose Subcutaneous	CDK10	0.37	0.20	enet	50	0.26	4.0e-21	6.6	-5.5	3.5e-08	0.60	0.19	0.81	FALSE
5	GTEx	Adipose Visceral Omentum	SPATA33	0.16	0.10	lasso	3	0.07	1.2e-04	-7.2	-7.0	3.7e-12	0.97	0.01	0.99	FALSE
6	GTEx	Adrenal Gland	SPATA33	0.21	0.12	enet	15	0.18	6.9e-07	6.9	-5.4	5.4e-08	0.76	0.02	0.97	FALSE
7	GTEx	Artery Aorta	SPATA2L	0.08	0.00	enet	10	0.05	6.6e-04	3.2	6.4	2.0e-10	-0.62	0.04	0.77	FALSE
8	GTEx	Artery Aorta	SPATA33	0.19	0.06	enet	15	0.12	3.7e-07	-7.0	-6.8	8.9e-12	0.86	0.01	0.99	FALSE
9	GTEx	Artery Aorta	CDK10	0.33	0.07	enet	27	0.18	2.7e-10	2.1	-5.3	1.2e-07	0.50	0.50	0.50	FALSE
10	GTEx	Artery Tibial	SPATA33	0.18	0.12	lasso	3	0.10	1.6e-08	-7.0	-7.4	1.9e-13	0.95	0.02	0.98	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ZNF276	0.20	0.06	enet	14	0.13	2.8e-04	-4.1	-5.3	1.5e-07	0.60	0.06	0.46	FALSE
12	GTEx	Breast Mammary Tissue	CDK10	0.45	0.22	lasso	6	0.23	7.1e-12	6.6	-6.7	1.7e-11	0.80	0.14	0.86	FALSE
13	GTEx	Breast Mammary Tissue (Male)	CDK10	0.12	0.08	enet	6	0.01	2.2e-01	-5.5	-5.5	3.9e-08	0.76	0.04	0.33	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CDK10	0.07	0.02	lasso	2	0.00	4.6e-01	6.6	-6.8	9.0e-12	0.79	0.04	0.43	FALSE
15	GTEx	Cells Transformed fibroblasts	SPATA33	0.11	0.05	enet	22	0.05	1.1e-04	-7.0	-6.0	1.9e-09	0.84	0.01	0.99	FALSE
16	GTEx	Cells Transformed fibroblasts	AC092143.1	0.07	0.00	lasso	6	0.00	5.0e-01	-7.0	-6.6	3.1e-11	0.90	0.04	0.68	FALSE
17	GTEx	Colon Transverse	SPATA33	0.23	0.16	enet	14	0.19	2.2e-09	-6.9	-6.1	1.2e-09	0.87	0.01	0.99	FALSE
18	GTEx	Colon Transverse	CDK10	0.34	0.15	lasso	5	0.16	4.2e-08	6.9	-6.3	2.8e-10	0.64	0.09	0.90	FALSE
19	GTEx	Esophagus Mucosa	CHMP1A	0.17	0.12	lasso	4	0.16	5.9e-11	5.5	5.8	8.3e-09	-0.73	0.11	0.89	FALSE
20	GTEx	Esophagus Mucosa	SPATA33	0.26	0.17	lasso	6	0.16	9.1e-11	-7.0	-7.2	4.1e-13	0.96	0.01	0.99	FALSE
21	GTEx	Esophagus Muscularis	SPATA33	0.25	0.18	lasso	11	0.17	1.7e-10	-7.2	-6.8	8.8e-12	0.95	0.00	1.00	FALSE
22	GTEx	Heart Atrial Appendage	CDK10	0.26	0.07	lasso	3	0.13	1.4e-06	-6.9	-6.6	3.6e-11	0.72	0.05	0.88	FALSE
23	GTEx	Heart Left Ventricle	SPATA33	0.07	0.02	enet	6	0.03	6.7e-03	-7.3	-6.7	1.6e-11	0.93	0.00	0.99	FALSE
24	GTEx	Lung	SPATA33	0.15	0.11	enet	9	0.13	5.6e-10	6.6	-7.4	1.0e-13	0.91	0.03	0.97	FALSE
25	GTEx	Lung	CDK10	0.25	0.18	lasso	7	0.19	1.0e-14	6.9	-6.6	5.3e-11	0.72	0.08	0.92	FALSE
26	GTEx	Muscle Skeletal	SPATA33	0.10	0.04	enet	5	0.05	8.3e-06	6.9	-7.2	4.5e-13	0.90	0.01	0.99	FALSE
27	GTEx	Nerve Tibial	CDK10	0.42	0.28	enet	16	0.35	1.2e-25	6.6	-6.4	1.7e-10	0.72	0.16	0.84	FALSE
28	GTEx	Ovary	CDK10	0.45	0.11	lasso	8	0.25	6.8e-07	2.1	-6.0	1.8e-09	0.68	0.04	0.86	FALSE
29	GTEx	Pancreas	SPATA33	0.13	0.14	lasso	10	0.11	2.2e-05	-7.2	-6.9	4.0e-12	0.98	0.01	0.99	FALSE
30	GTEx	Pancreas	CDK10	0.18	-0.01	lasso	5	0.02	5.1e-02	6.9	-5.4	5.4e-08	0.65	0.04	0.63	FALSE
31	GTEx	Pituitary	SPATA33	0.29	0.18	lasso	6	0.15	1.6e-04	6.9	-6.9	6.1e-12	0.69	0.03	0.77	FALSE
32	GTEx	Pituitary	CDK10	0.41	0.22	enet	17	0.15	1.2e-04	6.9	-6.8	8.2e-12	0.68	0.03	0.89	FALSE
33	GTEx	Pituitary	VPS9D1-AS1	0.21	-0.01	lasso	9	-0.01	5.7e-01	2.1	5.5	4.6e-08	-0.56	0.06	0.14	FALSE
34	GTEx	Prostate	SPATA33	0.35	0.01	lasso	5	0.05	2.8e-02	-7.2	-5.5	5.1e-08	0.75	0.02	0.82	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	CHMP1A	0.25	0.01	enet	21	0.08	5.3e-05	5.5	6.2	4.6e-10	-0.50	0.09	0.84	FALSE
36	GTEx	Skin Not Sun Exposed Suprapubic	SPATA33	0.12	0.09	lasso	4	0.10	3.4e-06	-7.0	-7.2	4.3e-13	0.97	0.01	0.99	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	CDK10	0.27	0.19	lasso	9	0.28	1.2e-15	6.6	-5.8	7.4e-09	0.65	0.17	0.83	FALSE
38	GTEx	Skin Sun Exposed Lower leg	CHMP1A	0.36	0.11	enet	29	0.19	1.5e-15	5.5	6.7	2.0e-11	-0.79	0.05	0.95	FALSE
39	GTEx	Skin Sun Exposed Lower leg	SPATA33	0.10	0.01	enet	25	0.05	6.3e-05	3.1	-5.3	1.4e-07	0.63	0.14	0.79	FALSE
40	GTEx	Skin Sun Exposed Lower leg	CDK10	0.30	0.18	enet	18	0.29	3.0e-24	2.1	-5.6	2.6e-08	0.57	0.80	0.20	FALSE
41	GTEx	Spleen	SPATA33	0.20	0.00	lasso	5	0.01	1.5e-01	6.9	5.8	8.7e-09	-0.61	0.03	0.69	FALSE
42	GTEx	Spleen	CDK10	0.36	0.22	enet	6	0.06	1.3e-02	6.9	-6.9	6.2e-12	0.75	0.05	0.78	FALSE
43	GTEx	Stomach	CDK10	0.35	0.12	enet	12	0.22	6.4e-11	2.1	-5.7	1.3e-08	0.53	0.64	0.29	FALSE
44	GTEx	Testis	CDK10	0.28	0.14	lasso	6	0.24	4.1e-11	6.9	-5.9	3.3e-09	0.64	0.06	0.94	FALSE
45	GTEx	Testis	VPS9D1-AS1	0.14	0.03	lasso	6	0.06	1.7e-03	-3.9	6.1	1.2e-09	-0.57	0.11	0.42	FALSE
46	GTEx	Thyroid	SPATA33	0.20	0.18	lasso	6	0.19	2.7e-14	-7.0	-6.7	1.7e-11	0.94	0.01	0.99	FALSE
47	GTEx	Thyroid	CDK10	0.36	0.16	lasso	9	0.21	9.7e-16	-7.0	-7.5	9.5e-14	0.89	0.02	0.98	FALSE
48	GTEx	Thyroid	VPS9D1-AS1	0.19	0.06	enet	25	0.06	2.0e-05	6.9	5.2	1.5e-07	-0.61	0.09	0.91	FALSE
49	GTEx	Whole Blood	SPATA33	0.05	0.02	enet	9	0.02	6.3e-03	-6.9	-6.9	7.1e-12	0.87	0.03	0.96	FALSE
50	METSIM	Adipose	CHMP1A	0.27	0.05	lasso	9	0.07	1.3e-10	5.5	5.7	1.1e-08	-0.58	0.03	0.97	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHMP1A	0.10	0.07	lasso	2	0.09	6.7e-08	5.5	7.1	1.2e-12	-0.88	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHMP1A	0.04	0.03	enet	9	0.05	7.5e-10	-7.0	7.6	2.1e-14	-0.87	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	CHMP1A	0.05	0.03	blup	38	0.04	1.6e-03	-7.6	7.7	2.0e-14	-0.94	0.01	0.96	TRUE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHMP1A	0.04	0.04	lasso	4	0.05	6.3e-06	-7.6	6.8	8.9e-12	-0.94	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPEP1	0.04	0.01	enet	6	0.03	1.0e-04	-6.9	-6.3	3.9e-10	0.66	0.02	0.75	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf55	0.03	0.05	enet	6	0.05	3.5e-06	-6.8	7.3	2.5e-13	-0.96	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHMP1A	0.07	0.03	blup	37	0.03	1.3e-04	5.5	5.8	8.2e-09	-0.79	0.00	0.99	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	DPEP1	0.06	0.01	blup	44	0.02	1.6e-03	5.4	6.4	1.6e-10	-0.64	0.07	0.65	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	CDK10	0.08	0.04	lasso	2	0.03	1.1e-04	6.6	-6.5	6.9e-11	0.73	0.16	0.40	FALSE
60	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CHMP1A	0.06	0.05	blup	37	0.05	2.9e-06	5.5	5.7	1.5e-08	-0.84	0.02	0.98	FALSE
61	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SPIRE2	0.04	0.05	lasso	1	0.01	4.9e-02	-5.3	5.3	9.5e-08	-0.67	0.00	0.89	FALSE
62	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDK10	0.20	0.02	enet	15	0.08	5.3e-04	5.5	-5.5	3.7e-08	0.61	0.02	0.76	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHMP1A	0.04	0.05	enet	3	0.05	2.1e-06	-7.6	7.6	2.5e-14	-0.97	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	C16orf55	0.09	0.04	blup	36	0.04	7.1e-04	6.9	-6.6	5.2e-11	0.73	0.11	0.73	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf55	0.04	0.01	blup	36	0.02	1.7e-03	-7.0	-6.5	1.0e-10	0.92	0.01	0.74	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	CDK10	0.06	0.04	blup	43	0.04	8.9e-05	6.6	-6.3	3.1e-10	0.51	0.25	0.54	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	CHMP1A	0.11	0.09	blup	38	0.08	5.1e-08	-7.6	5.4	7.3e-08	-0.79	0.00	1.00	FALSE