Best TWAS P=2.68e-09 · Best GWAS P=3.93e-09 conditioned to 0.0231
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PROCR | 0.05 | 0.04 | lasso | 6 | 0.03 | 8.0e-05 | 4.9 | -5.2 | 2.1e-07 | -0.86 | 0.04 | 0.95 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | PROCR | 0.14 | 0.13 | lasso | 2 | 0.11 | 1.9e-08 | 5.9 | -5.9 | 4.7e-09 | -1.00 | 0.00 | 1.00 | FALSE |
3 | GTEx | Lung | TRPC4AP | 0.07 | 0.00 | lasso | 6 | 0.00 | 6.6e-01 | 4.9 | -5.7 | 1.0e-08 | -0.91 | 0.04 | 0.58 | FALSE |
4 | GTEx | Whole Blood | TRPC4AP | 0.10 | 0.03 | lasso | 4 | 0.02 | 7.9e-03 | 5.9 | -5.7 | 1.4e-08 | -0.98 | 0.01 | 0.98 | FALSE |
5 | METSIM | Adipose | EIF6 | 0.07 | 0.02 | bslmm | 343 | 0.04 | 2.7e-07 | 5.6 | 6.0 | 2.7e-09 | 0.73 | 0.02 | 0.98 | TRUE |
6 | METSIM | Adipose | PROCR | 0.04 | 0.00 | bslmm | 351 | 0.01 | 2.4e-02 | 4.8 | -5.9 | 4.7e-09 | -0.71 | 0.07 | 0.73 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | TRPC4AP | 0.05 | 0.03 | lasso | 4 | 0.03 | 8.7e-05 | 5.4 | -5.4 | 7.2e-08 | -0.98 | 0.04 | 0.95 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PROCR | 0.05 | 0.02 | blup | 44 | 0.05 | 1.3e-09 | 5.9 | -5.8 | 5.3e-09 | -0.90 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Colon Adenocarcinoma | PROCR | 0.09 | 0.07 | lasso | 2 | 0.06 | 2.0e-04 | 5.3 | -5.4 | 5.5e-08 | -0.98 | 0.01 | 0.97 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PROCR | 0.10 | 0.11 | lasso | 4 | 0.12 | 5.5e-13 | 5.4 | -5.5 | 3.4e-08 | -0.97 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PROCR | 0.04 | 0.05 | lasso | 4 | 0.03 | 3.6e-04 | 5.9 | -5.8 | 5.5e-09 | -0.99 | 0.00 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PROCR | 0.10 | 0.06 | lasso | 3 | 0.06 | 2.8e-05 | 5.3 | -5.2 | 1.7e-07 | -0.98 | 0.01 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | PROCR | 0.09 | 0.06 | blup | 45 | 0.08 | 3.0e-08 | 5.4 | -5.3 | 1.1e-07 | -0.92 | 0.01 | 0.99 | FALSE |