Hub : Genes

EIF6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.3230	0.0990	1.3e-03	0.021	NA	0.070	NA	0.081	8.0e-02	NA	4.8e-03	NA	2.5e-03
2	GTEx	Brain Hippocampus	0.4048	0.1350	1.2e-03	-0.004	NA	-0.012	NA	0.052	4.2e-01	NA	7.8e-01	NA	2.4e-02
3	GTEx	Lung	0.1967	0.0650	2.2e-05	0.102	NA	0.081	NA	0.087	3.2e-08	NA	9.1e-07	NA	3.4e-07
4	GTEx	Muscle Skeletal	0.3177	0.0531	0.0e+00	0.251	NA	0.249	NA	0.266	1.6e-24	NA	2.8e-24	NA	4.6e-26
5	GTEx	Skin Not Sun Exposed Suprapubic	0.3240	0.0850	1.6e-05	0.113	NA	0.035	NA	0.070	9.0e-07	NA	5.1e-03	NA	1.1e-04
6	GTEx	Skin Sun Exposed Lower leg	0.4000	0.0770	2.5e-13	0.210	NA	0.158	NA	0.190	3.0e-17	NA	4.4e-13	NA	1.2e-15
7	METSIM	Adipose	0.0719	0.0293	1.0e-06	0.022	0.043	0.032	0.044	0.040	2.6e-04	4.2e-07	1.2e-05	2.7e-07	9.1e-07
8	NTR	Blood	0.0698	0.0243	2.3e-12	0.053	0.042	0.049	0.047	0.051	1.4e-16	2.0e-13	1.5e-15	6.7e-15	4.1e-16
9	YFS	Blood	0.0194	0.0087	5.3e-05	0.004	0.012	0.008	0.012	0.006	1.6e-02	4.1e-05	7.6e-04	4.3e-05	2.7e-03
10	TCGA	Glioblastoma Multiforme	0.1590	0.0880	9.5e-03	0.038	0.056	0.009	NA	0.043	2.6e-02	8.6e-03	1.7e-01	NA	1.9e-02
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0340	0.0202	3.3e-03	0.025	0.026	0.030	NA	0.018	6.8e-04	5.4e-04	2.4e-04	NA	3.6e-03
12	TCGA	Brain Lower Grade Glioma	0.2028	0.0985	1.2e-06	0.014	0.030	0.043	NA	0.036	9.7e-03	2.3e-04	1.1e-05	NA	5.2e-05
13	TCGA	Pancreatic Adenocarcinoma	0.3070	0.1110	1.4e-04	0.109	0.074	0.038	NA	0.081	2.5e-05	5.0e-04	1.0e-02	NA	2.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.9	1.4	9.1	2.1	-3.0	0.2	0.6	0.6	1.3	0.2	-0.4	-0.5	-1.0	-0.5	0.3	-0.1
Bipolar Disorder or Schizophrenia	0.9	2.2	8.8	2.0	-3.0	-0.1	1.0	1.0	1.7	1.4	-1.1	-0.6	-2.1	-0.8	1.4	-0.4
Depressed Affect (Nagel 2018)	1.0	2.1	6.3	-1.2	-0.4	-2.0	-0.9	-1.0	-0.9	-0.4	-2.5	-0.8	-0.2	-0.8	-2.3	-2.4
Depression (Nagel 2018)	1.0	1.5	4.3	-1.5	-1.6	-1.6	-0.4	-0.4	0.0	-0.2	-2.1	-0.1	-1.3	-1.1	-1.0	-2.0
Intelligence (Savage-Jansen 2018)	0.5	1.5	9.1	0.1	-3.0	1.0	-1.1	-0.3	-0.3	1.9	0.4	-0.2	-1.2	-1.4	-0.8	0.3
Neuroticism (Nagel 2018)	1.0	2.3	7.8	-1.6	-0.2	-2.1	-0.9	-0.9	-1.2	0.4	-2.2	0.5	-0.4	-0.8	-2.8	-2.5
Schizophrenia (2018)	0.5	1.1	2.5	0.8	-1.2	-0.4	0.8	0.8	1.2	1.5	-1.1	-0.4	-1.6	-0.7	1.4	-0.5
Schizophrenia vs Biploar Disorder	0.8	1.1	2.9	-0.8	1.4	0.3	1.4	1.1	0.8	1.4	-0.4	1.0	1.7	1.1	-0.1	-0.0
Worry (Nagel 2018)	0.5	1.1	6.1	-1.3	-0.1	-0.7	-0.3	-0.3	-0.7	1.4	-0.3	1.7	-0.6	-0.6	-2.5	-0.4
Alzheimer’s Disease (in mother)	0.8	0.9	1.9	0.7	0.4	-1.4	-1.0	-1.1	-1.2	-0.7	-1.1	0.4	-1.4	-0.8	-0.2	-1.2
Alzheimer’s Disease (in father)	0.6	0.6	3.1	0.6	0.3	-0.3	-0.8	-1.0	-1.0	-0.6	-0.4	0.3	0.2	-0.8	-1.8	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.1	0.3	0.4	-0.8	-0.6	-1.0	-1.0	-0.6	-0.5	0.9	-0.3	-0.2	-0.9	-0.7
Crohns Disease (2017)	0.8	1.8	5.2	0.3	0.5	1.6	1.5	1.7	1.6	0.1	1.7	-0.0	0.9	1.4	2.3	1.6
Irritable Bowel Disease (IBD)	3.5	8.3	14.1	-0.1	-1.5	3.2	3.5	3.8	3.6	3.3	2.9	1.8	1.2	3.0	3.4	3.3
Ulcerative Colitis (UC)	5.9	11.1	24.8	0.1	-2.4	3.6	4.2	4.4	4.2	5.0	2.9	2.5	1.2	3.3	2.7	3.6
Major Depression (MDD)	2.1	2.5	6.1	-1.3	-0.4	-2.5	-1.3	-1.4	-1.1	-0.5	-2.4	-1.8	-1.2	-1.4	-1.5	-2.2
Reaction Time	1.3	2.5	12.8	0.2	1.7	-2.0	-1.2	-1.6	-1.4	-3.6	-1.2	-1.6	-0.4	-0.6	-1.2	-1.3
Verbal and Numeric Reasoning (VNR)	0.5	1.2	8.4	1.0	-2.9	0.7	-0.4	0.0	0.2	2.0	-0.0	0.2	-0.8	-0.5	-0.8	-0.0
Breast Cancer	0.7	1.6	4.3	2.1	1.4	-1.1	-0.9	-1.0	-0.8	-1.7	-0.4	-1.7	-0.7	-1.1	-1.5	-0.7
Ovarian Cancer	0.5	0.6	3.1	1.4	0.9	-0.2	0.4	0.2	0.3	-1.8	0.0	-0.5	-0.8	-0.4	1.0	-0.1
Prostate Cancer	1.5	2.0	5.5	-1.6	1.9	-1.1	-1.7	-1.7	-2.3	-0.8	-0.7	-0.8	1.7	0.1	-1.7	-0.8
Age at First Birth	1.8	2.6	9.1	1.4	-0.1	1.8	1.6	1.8	1.5	3.0	1.7	1.8	-0.1	1.3	0.5	2.0
Bipolar Disorder (2011)	1.6	1.6	8.5	2.9	-0.5	1.3	1.2	1.2	1.6	1.1	1.3	-0.4	-0.4	-0.0	0.8	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	5.5	1.0	-0.1	-0.6	-0.1	-0.1	0.6	-1.3	-0.9	-0.5	-1.6	-2.3	0.4	-1.2
Coronary Artery Disease (CAD)	1.2	1.5	4.5	0.7	-1.4	-0.5	0.7	0.8	1.5	-0.3	-1.6	-0.0	0.3	-2.1	-1.5	-1.9
Crohns Disease (2012)	1.7	2.7	5.8	0.7	-0.8	2.1	1.6	1.8	1.5	0.6	2.1	0.7	0.9	2.2	2.4	2.2
Mean Putamen Volume	0.3	0.4	1.0	0.6	0.3	0.6	0.4	0.5	0.7	0.2	1.0	0.2	-1.0	-0.0	-0.3	1.0
Fasting Glucose	0.3	0.4	1.1	1.0	-0.4	0.7	0.3	0.3	0.1	1.1	0.8	0.4	-0.8	-0.3	-0.1	0.8
HbA1C	0.4	0.4	1.4	-0.3	0.5	-0.3	-0.8	-0.8	-1.0	-1.2	0.3	-1.1	0.0	-0.5	0.0	0.2
HDL Cholesterol	0.8	1.4	6.8	0.2	2.6	-0.6	-0.6	-1.0	-1.5	-1.7	-0.0	-1.3	0.9	0.9	-1.0	-0.1
LDL Cholesterol	1.0	1.6	13.8	1.5	3.7	-0.0	-0.5	-0.7	-1.0	-1.1	0.1	-0.9	0.8	0.3	-0.7	0.1
Lupus	3.0	4.5	8.7	1.6	1.2	3.0	2.1	2.3	2.0	2.2	2.6	2.3	1.6	2.4	1.1	2.4
Neuroticism (2016)	1.2	1.8	3.3	-1.8	-1.2	-1.8	-1.2	-1.2	-1.1	-0.6	-1.8	-0.3	-1.4	-1.3	-1.0	-1.6
Primary Biliary Cirrhosis	0.3	0.5	2.8	-1.7	-0.5	-0.2	0.7	0.5	0.9	0.3	-0.5	0.6	-0.1	0.3	1.0	-0.1
Rheumatoid Arthritis	1.6	2.1	11.2	-3.3	2.1	0.8	0.6	0.8	0.3	0.4	1.4	1.1	2.3	1.1	0.3	1.0
Schizophrenia (2014)	0.5	1.1	2.7	1.0	-1.5	-0.1	1.2	1.2	1.6	1.5	-0.8	-0.1	-1.0	-0.1	1.2	-0.2
Triglycerides	0.7	1.2	4.0	1.6	2.0	0.7	0.9	0.8	1.2	-0.7	0.5	-0.3	-0.4	-0.6	1.8	0.8
Type 2 Diabetes (T2D) (2012)	1.2	1.3	4.3	0.6	-1.9	1.5	0.6	1.0	0.9	2.1	1.3	1.0	-0.0	0.5	0.1	1.3
Ulcerative Colitis	6.7	9.7	18.5	-0.7	-2.9	3.5	3.7	3.9	3.8	4.3	2.7	2.3	1.1	2.8	3.0	3.5
Blood Eosinophil Count	0.2	1.6	5.2	-1.4	-1.0	-1.4	-1.0	-0.9	-0.5	-1.2	-0.8	-2.3	-1.5	-1.6	-0.2	-1.1
Blood Platelet Count	0.2	2.6	11.4	-0.1	-3.2	0.5	-0.4	-0.0	-0.7	3.4	1.4	0.4	0.7	-0.2	-2.7	1.0
Blood Red Count	0.4	3.8	15.1	3.9	0.9	-0.6	-2.0	-2.0	-2.5	-1.1	0.9	0.6	-2.2	-2.2	-2.5	0.4
Blood White Count	0.2	1.5	3.9	1.1	-1.8	-1.3	-0.3	-0.5	0.2	-0.4	-1.6	0.3	-2.0	-1.9	-0.1	-1.5
Heel T-Score	0.9	7.4	37.0	6.1	-3.3	-1.2	-0.9	-0.8	-0.5	2.2	-1.4	-2.1	-4.4	-3.2	-1.5	-1.1
BMI	1.3	7.3	16.5	0.4	-2.9	-2.7	-1.2	-1.1	0.3	-2.3	-4.0	-3.8	-2.9	-4.1	-0.5	-3.8
Height	19.6	377.3	800.9	-1.6	-16.6	22.4	20.9	24.4	28.3	25.6	14.3	23.8	-1.7	11.6	21.2	16.7
Waist Hip Ratio (WHR)	2.1	9.3	22.3	-4.4	3.9	-2.9	-2.9	-3.4	-4.7	-2.7	-0.6	-1.8	3.3	-0.1	-3.7	-1.1
Systolic Blood Pressure	1.6	7.9	20.1	1.4	-3.8	3.0	2.9	3.2	3.7	2.0	2.4	1.5	-1.4	1.7	4.5	2.9
Smoking Status	0.6	1.5	4.0	-1.8	0.6	-0.8	-1.4	-1.6	-2.0	-1.9	-0.7	0.0	1.2	-0.3	-0.8	-0.7
Allergy or Eczema	0.4	1.0	4.7	0.8	0.4	0.5	0.7	0.9	0.8	2.2	1.3	0.6	-0.9	-0.4	-1.0	1.1
Cardiovascular Disease	1.2	3.9	8.5	-0.6	-1.5	-2.6	-1.7	-1.8	-1.2	-2.9	-2.6	-2.3	-1.8	-1.8	-0.2	-2.5
Hypothyroidism (self reported)	0.5	1.1	5.2	-1.4	-2.3	0.8	0.7	0.8	1.2	1.6	0.1	0.7	-0.1	-0.2	0.4	0.6
Respiratory disease	1.2	2.8	8.7	-2.1	-2.7	1.3	1.4	1.7	1.8	2.9	1.1	1.5	-0.8	0.2	0.6	1.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.0	0.1	-1.0	0.1	-0.2	0.1	0.2	0.3	0.0	-0.9	-0.3	-0.8	-0.3	0.0
Lung FEV1/FVC ratio	2.9	14.5	40.4	0.8	-2.2	5.0	3.6	4.1	4.1	6.4	3.6	5.0	2.5	3.0	1.9	3.9
Lung FVC	4.1	20.8	46.6	-5.5	5.6	-5.7	-4.5	-5.6	-6.8	-5.1	-3.6	-2.4	1.3	-0.7	-3.9	-3.9
Neuroticism	1.0	2.4	6.4	-1.8	-1.4	-1.9	-1.1	-1.0	-1.0	0.3	-2.5	0.2	-0.8	-1.2	-2.1	-2.4
Chronotype (morning person)	2.0	4.7	9.7	-1.3	-0.7	1.9	2.4	2.5	2.3	3.0	2.4	3.1	0.7	1.9	1.6	2.5
Hair Pigment	5.9	167.0	558.6	-9.6	11.3	-14.0	-15.3	-16.9	-23.6	-13.3	-8.6	9.4	-4.8	-4.7	-13.4	-10.6
Tanning	15.2	185.2	552.2	8.2	-10.8	15.2	16.4	17.9	23.5	14.8	11.1	-6.3	5.7	8.2	14.1	13.1
Hand grip strength (left)	11.9	31.3	64.0	3.0	-3.5	6.7	6.4	7.1	8.0	6.3	4.5	6.0	-0.4	3.8	6.9	5.2
Number of treatments/medications taken	2.2	4.0	11.0	-3.3	-1.4	-2.7	-1.5	-1.5	-0.9	-0.3	-2.4	-0.1	-1.9	-3.2	-0.9	-2.3
Average weekly spirits intake	0.6	0.7	5.4	0.2	-0.2	-0.3	0.6	0.3	0.6	-0.5	-1.2	0.3	-0.5	-0.1	2.3	-0.9
Sensitivity / hurt feelings	1.4	2.4	6.4	-2.0	2.0	-2.3	-0.3	-0.6	-0.7	-0.1	-2.5	0.8	0.6	-0.3	-1.8	-2.5
Frequency of depressed mood in last 2 weeks	1.9	2.6	7.7	-2.1	-1.0	-2.4	-0.9	-1.0	-0.6	-1.3	-2.7	-0.7	-0.6	-1.0	-1.5	-2.8
Hearing difficulty/problems: Yes	1.1	1.6	6.1	0.2	1.1	-0.4	-1.9	-1.7	-2.5	1.2	0.8	0.8	-0.5	-1.2	-1.5	0.2
Relative age of first facial hair	1.0	2.1	7.6	-1.1	2.8	-0.7	-1.3	-1.5	-2.5	-0.7	0.3	-0.9	2.5	0.7	-1.0	-0.1
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	10.7	-3.3	-0.4	-1.7	-0.7	-1.0	-1.0	0.7	-2.1	1.2	0.6	-0.4	-0.7	-1.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	2.5	0.0	-1.6	0.0	0.6	0.5	0.5	0.7	-0.4	0.5	-0.1	0.3	-0.1	0.1
Ever had hysterectomy (womb removed)	0.2	0.3	0.9	-0.8	0.4	-0.6	-0.0	-0.2	-0.2	-0.9	0.1	-0.4	-0.3	-0.1	1.0	0.3
Systolic blood pressure, automated reading	1.7	5.0	8.8	2.6	-3.0	2.3	2.1	2.4	2.7	2.3	1.6	1.5	-1.5	0.6	2.9	2.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	3.2	-1.8	-0.1	-0.7	-0.6	-0.4	-0.4	0.0	-0.7	-0.1	-0.5	-0.0	-0.2	-0.8
Angina	2.1	2.8	8.4	0.1	-0.7	-2.3	-0.7	-0.7	-0.1	-0.8	-2.4	-1.1	-1.5	-2.9	-2.0	-2.7
Medication for hormone replacement therapy	0.7	0.7	2.6	0.1	-0.3	0.6	1.2	0.9	0.7	0.3	0.7	0.2	1.4	1.6	0.4	1.0
Vitamin and mineral supplements	3.1	4.2	9.7	0.4	1.3	-1.5	-3.0	-2.9	-3.0	-3.1	-1.3	-2.1	-1.0	-2.0	-1.1	-1.7
Supplements: Zinc	2.3	2.5	6.6	0.0	-1.5	1.1	1.9	2.1	2.6	1.5	1.4	-0.0	-1.2	0.7	2.3	1.6
Medication: Co-codamol	1.3	1.5	3.6	-1.9	-0.8	-1.7	-1.2	-1.4	-1.4	-1.5	-1.5	-0.0	0.3	-0.4	-0.8	-1.4
Medication: Metformin	0.2	0.3	1.8	-0.2	-1.3	0.2	0.0	0.2	0.6	0.1	-0.4	-0.3	-0.0	-0.7	0.6	-0.4
Diabetes (father)	0.3	0.4	2.6	0.6	-0.5	0.1	-0.1	0.0	0.5	-0.6	-0.4	-1.0	0.1	-1.6	0.1	-0.3
Diabetes (mother)	1.2	1.5	5.2	0.7	-2.3	0.2	0.9	0.9	1.6	0.0	-0.3	0.9	-1.9	-1.3	2.0	0.1
Severe depression (siblings)	0.5	0.6	3.7	-0.2	-1.4	-0.1	0.3	0.4	0.5	1.9	-0.3	0.5	-0.7	0.2	-0.6	0.2
Pack years adult smoking proportion	1.4	2.1	4.9	-1.3	-1.0	0.6	1.7	1.6	1.8	2.1	0.3	2.2	1.5	1.8	-0.2	0.7
Impedance of leg (right)	2.8	13.7	40.4	0.9	4.5	-3.5	-4.3	-5.0	-6.4	-4.1	-1.7	-3.2	1.1	-0.5	-5.1	-2.0
Leg fat-free mass (left)	12.0	63.5	174.2	0.1	-8.5	8.3	9.2	10.7	13.2	9.7	4.2	8.2	-2.1	2.9	9.6	5.2
Trunk fat percentage	1.1	4.4	13.7	-0.5	-0.9	-2.6	-0.9	-0.9	0.1	-2.0	-3.7	-1.1	-2.0	-3.1	-1.8	-3.4
Hand grip strength (right)	14.0	38.1	79.0	2.3	-4.7	7.5	6.9	7.9	8.9	7.3	4.8	6.3	-0.7	4.2	7.4	5.7
Townsend deprivation index at recruitment	1.8	2.5	6.4	-2.5	0.5	-1.8	-1.4	-1.6	-1.9	-1.2	-1.6	-1.2	1.1	-0.5	-2.0	-1.8
Current tobacco smoking	0.6	1.0	4.8	-2.2	-0.2	-0.4	1.0	0.7	0.7	-0.7	-1.0	0.2	1.7	1.1	0.2	-0.6
Average weekly fortified wine intake	1.2	1.4	3.6	1.5	0.1	1.6	1.2	1.2	1.1	0.8	1.1	0.8	-0.5	1.2	1.9	1.5
Maternal smoking around birth	1.1	1.5	8.4	-2.9	0.9	0.0	-0.0	-0.2	-0.8	-0.1	0.7	0.6	2.9	0.5	-0.9	0.4
Fed-up feelings	2.8	5.1	13.8	-1.6	-0.5	-3.3	-1.4	-1.4	-1.0	-1.3	-3.7	-2.2	-0.3	-2.0	-3.2	-3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.8	-2.0	-1.4	-1.7	-0.9	-0.9	-0.6	-1.1	-1.8	0.0	-1.4	-1.3	-1.4	-1.8
Relative age voice broke	1.9	2.8	11.8	0.1	2.8	-1.0	-2.2	-2.4	-3.4	-0.7	0.4	-0.4	1.4	-0.6	-1.7	-0.2
Taking other prescription medications	0.9	1.3	6.0	-2.4	-0.6	-1.4	-0.8	-0.8	-0.5	0.3	-1.2	0.0	-0.8	-1.9	-0.7	-1.1
Age when periods started (menarche)	2.4	5.9	12.4	0.1	3.3	2.4	0.9	1.0	-0.4	3.5	3.5	1.8	3.5	2.9	-0.7	2.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	2.6	-1.6	-0.5	-0.5	0.3	0.2	0.3	-0.1	-0.4	-0.6	-0.4	-0.0	-0.1	0.0
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	15.0	3.6	-2.0	-1.0	-1.8	-1.5	-1.0	-0.5	-1.3	-2.3	-3.9	-3.1	-0.7	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.8	0.2	1.0	1.1	0.4	0.5	0.4	0.1	1.3	1.4	-0.2	0.0	-0.5	1.0
Qualifications: CSEs or equivalent	0.6	0.7	4.2	-0.4	1.4	-0.2	0.5	0.1	-0.0	-2.1	-0.2	-0.8	0.5	0.8	1.3	0.1
Serious illness, injury or assault to yourself	0.8	1.0	1.9	-1.0	-0.8	-1.2	-0.7	-0.8	-0.7	-1.0	-1.2	-0.6	-0.9	-1.4	-0.6	-1.2
High blood pressure	1.3	3.6	6.7	-2.2	-2.2	-2.4	-1.5	-1.6	-0.8	-1.8	-2.3	-1.6	-1.9	-2.6	-0.3	-2.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.5	0.9	0.9	0.3	1.5	1.6	1.7	1.9	1.0	0.5	-0.7	0.1	-0.4	0.7
Multivitamins +/- minerals	2.6	3.3	9.8	0.4	-0.8	1.3	2.8	2.8	3.1	3.0	1.1	1.3	0.3	0.8	0.5	1.3
Stomach or abdominal pain in last month	1.1	1.4	2.7	0.2	0.1	-1.2	-1.6	-1.6	-1.6	-1.2	-1.2	-0.4	-0.6	-1.6	-0.9	-1.2
Supplements: Glucosamine	0.6	0.7	2.7	1.6	-1.3	-0.1	0.2	0.2	0.4	1.4	-0.6	0.8	-1.1	-0.2	0.9	-0.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	4.1	-0.9	-0.4	-1.6	-0.8	-1.1	-1.0	-0.3	-1.6	-0.4	-0.3	-0.3	-2.0	-1.5
Medication: Atenolol	0.5	0.6	1.8	0.0	0.1	-0.9	0.9	1.0	1.3	-0.1	-1.0	-0.9	-0.1	-0.7	-0.2	-1.2
Medication: Levothyroxine sodium	0.5	0.8	4.1	-1.2	-2.0	-0.2	-0.6	-0.5	-0.0	0.8	-0.7	0.6	-0.9	-1.1	-0.4	-0.5
Sitting height	24.6	174.6	416.2	3.1	-11.5	15.6	14.7	17.4	20.4	17.4	9.9	13.5	-2.7	6.4	13.8	11.3
Chronic bronchitis/emphysema (father)	0.9	1.1	2.7	-1.5	1.1	-1.4	-0.7	-1.0	-0.7	-0.6	-1.6	-0.3	-0.5	-1.1	-0.5	-1.3
High blood pressure (mother)	0.4	0.5	2.0	1.3	-1.4	0.5	-0.2	0.0	0.4	0.3	0.3	-0.2	-0.6	-1.3	0.5	0.3
Body mass index (BMI)	1.9	8.1	19.6	0.1	-2.5	-3.4	-1.7	-1.7	-0.5	-2.3	-4.4	-3.2	-2.5	-4.2	-1.7	-4.3
Impedance of leg (left)	2.8	13.6	42.1	0.2	4.2	-3.5	-4.4	-5.0	-6.5	-4.1	-1.6	-3.3	1.0	-0.3	-4.9	-1.8
Leg predicted mass (left)	12.3	65.0	179.6	0.1	-8.4	8.5	9.3	10.8	13.4	9.8	4.3	8.2	-2.0	3.1	9.7	5.3
Trunk fat mass	1.1	4.5	15.1	-0.3	-3.8	0.5	1.8	2.3	3.9	1.7	-1.7	1.7	-2.3	-1.6	1.4	-1.2
Waist circumference	0.8	2.9	10.5	-1.9	-3.2	-1.3	-0.1	0.3	1.4	0.2	-2.5	-0.4	-1.7	-2.3	0.3	-2.2
Number of incorrect matches in round	0.5	0.8	3.0	1.4	1.7	0.1	-0.8	-1.1	-1.1	-1.2	0.1	0.9	-0.2	-0.7	-0.5	0.0
Past tobacco smoking	1.3	2.5	5.2	2.3	-1.6	1.3	1.6	1.8	2.3	2.1	0.9	0.0	-1.3	0.6	1.7	1.2
Alcohol usually taken with meals	0.4	0.6	2.7	0.7	-1.6	-0.2	0.0	0.3	0.7	0.1	-0.7	-0.6	-1.0	0.1	1.2	-0.7
Nervous feelings	0.6	1.1	3.3	-1.5	-0.2	-0.9	-0.2	-0.3	-0.9	1.2	-1.1	1.8	0.7	0.5	-1.5	-1.1
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.7	12.8	-2.5	-2.0	-3.2	-2.3	-2.5	-2.2	-2.1	-3.4	-0.7	-1.4	-1.3	-2.0	-3.6
Hearing difficulty/problems with background noise	0.7	1.0	5.0	0.1	0.5	0.5	-0.2	-0.2	-0.7	2.2	0.9	2.2	0.4	0.6	-0.9	0.8
Hair/balding pattern: Pattern 2	2.0	2.5	7.5	-0.7	0.2	-2.1	-1.3	-1.5	-1.5	-1.3	-2.7	-0.9	-0.6	-1.8	-1.4	-2.4
Had menopause	1.0	1.3	4.5	-0.8	-2.1	1.2	0.3	0.6	0.5	2.1	1.0	1.0	-0.6	-0.0	0.7	1.6
Had other major operations	0.4	0.5	1.7	-1.0	0.7	-1.1	0.2	0.1	0.3	-0.2	-0.6	0.0	-0.3	-1.3	-0.8	-0.8
Forced vital capacity (FVC)	3.0	11.5	19.8	-3.8	-1.4	3.0	3.5	3.9	4.4	4.0	1.7	4.4	0.5	3.6	4.3	2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	12.7	3.6	-2.6	0.3	-0.6	-0.3	0.1	0.3	-0.3	-1.3	-3.4	-1.6	0.6	0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.2	-1.1	-0.4	-0.3	0.3	0.3	0.5	-0.3	-0.6	0.2	0.1	0.6	0.0	-0.5
Qualifications: None of the above	1.0	2.0	4.3	-1.4	1.3	-1.7	-0.7	-1.1	-1.3	-2.1	-1.8	-2.0	1.3	-0.1	-1.2	-1.4
Financial difficulties in last 2 years	1.1	1.5	4.3	-2.1	-1.6	-1.6	0.3	0.2	0.5	-0.6	-2.1	-0.4	0.7	0.3	-0.6	-1.9
Mouth/teeth dental problems	1.9	2.9	7.3	1.2	-1.4	2.5	1.1	1.4	1.1	2.5	2.7	1.4	-0.1	0.5	1.4	2.5
Heart attack	5.3	6.8	16.0	-1.0	-0.5	-3.5	-2.6	-2.6	-2.2	-1.3	-3.0	-1.0	-2.4	-4.0	-3.3	-3.4
Allergy	1.4	3.2	12.8	-0.1	0.4	-1.3	-2.2	-2.4	-2.5	-3.6	-1.7	-1.6	0.3	-1.1	0.0	-1.7
Pain all over the body in last month	0.3	0.3	1.1	-1.1	0.1	-0.7	0.8	0.6	0.8	0.0	-0.7	0.6	0.1	0.3	0.1	-0.4
Diabetes (self-reported)	0.3	0.5	3.0	-0.9	-1.7	0.1	-0.2	0.1	0.5	0.4	-0.3	-0.3	-0.6	-1.0	-0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	7.0	-0.3	0.4	1.1	1.8	1.9	1.8	2.6	1.9	0.0	-0.7	1.4	0.9	2.1
Medication: Ramipril	2.2	2.8	8.7	-0.9	1.2	-2.0	-1.7	-1.5	-1.4	-0.7	-1.3	-1.0	-0.3	-3.0	-2.6	-2.0
Medication: Simvastatin	1.5	2.1	6.9	1.1	2.6	-1.5	-1.3	-1.4	-1.2	-1.6	-0.8	-0.5	-1.0	-2.3	-1.1	-1.2
Fluid intelligence score	1.1	2.2	13.2	0.2	-3.6	-0.3	-1.4	-0.8	-0.5	0.8	-0.9	-0.9	-1.6	-1.5	-2.1	-1.0
Illnesses of siblings	1.7	2.3	15.8	-0.4	4.0	1.0	1.0	0.9	0.4	-0.8	1.3	0.6	2.2	1.2	-0.9	1.2
Neuroticism score	1.4	2.9	9.0	-3.0	-1.0	-2.3	-1.0	-1.0	-1.1	-0.1	-2.7	0.0	-0.2	-1.0	-2.1	-2.6
Weight	4.8	23.6	73.5	0.1	-7.2	4.3	5.2	6.3	8.6	5.9	0.9	4.6	-2.7	0.2	5.4	1.7
Impedance of arm (right)	0.8	3.7	23.3	-0.9	4.8	-0.4	-0.4	-1.0	-2.0	-2.5	0.8	1.7	1.2	1.8	-1.5	0.8
Arm fat percentage (right)	2.1	8.3	22.6	-0.6	-0.7	-4.0	-1.7	-2.0	-1.2	-3.0	-4.8	-2.4	-2.0	-3.8	-2.5	-4.5
Trunk fat-free mass	16.4	94.1	222.0	0.5	-10.2	10.8	10.5	12.4	14.9	13.0	6.3	9.9	-2.1	4.4	11.4	7.5
Hip circumference	2.3	10.1	37.6	0.7	-6.1	1.9	2.9	3.6	5.6	2.8	-0.9	1.9	-3.2	-1.2	3.5	-0.3
Time employed in main current job	0.5	0.5	3.6	1.9	0.4	0.5	-0.1	-0.2	-0.2	-0.9	0.7	-0.1	-0.5	0.2	0.9	0.8
Alcohol intake versus 10 years previously	1.3	1.9	4.2	-2.0	-1.6	0.6	1.8	1.9	2.1	1.5	0.6	1.7	0.8	0.3	0.7	0.7
Father’s age at death	1.0	1.4	4.1	1.8	-0.4	1.6	-0.9	-0.7	-1.1	0.2	2.0	0.6	-0.2	0.3	1.6	1.6
Worrier / anxious feelings	0.6	1.0	3.3	-1.8	-0.4	-0.2	-0.2	-0.1	-0.6	1.8	0.5	1.7	0.2	0.1	-1.7	0.4
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	11.0	-0.9	-2.1	-2.3	-0.7	-0.6	0.3	-0.4	-3.3	-0.7	-2.6	-2.3	-1.4	-3.1
Falls in the last year	0.8	1.1	2.2	-0.3	-0.4	-1.4	-1.1	-1.2	-1.2	-0.1	-1.2	-0.2	-0.9	-1.1	-1.4	-1.5
Hair/balding pattern: Pattern 3	1.4	2.1	6.5	2.6	-1.1	1.7	0.3	0.7	0.9	2.0	1.8	1.0	-1.9	-0.6	0.5	1.7
Number of live births	0.3	0.4	1.4	0.3	-0.4	0.5	0.4	0.2	0.2	-0.8	0.5	-0.4	0.5	0.9	1.2	0.8
Forced expiratory volume in 1-second (FEV1)	2.9	9.6	18.3	-3.7	-1.6	2.8	3.1	3.5	3.9	4.3	1.5	4.2	1.0	3.2	3.1	2.0
Pulse rate	1.5	2.6	12.4	-3.5	1.7	0.2	1.2	0.7	0.3	-0.1	0.9	0.9	2.3	2.6	0.2	1.4
Happiness	1.6	2.0	5.2	-0.8	-0.3	-2.3	-0.7	-0.7	-0.5	-1.1	-2.2	-1.0	-0.1	-1.6	-2.0	-2.3
Noisy workplace	0.3	0.4	1.8	-0.8	0.6	-0.7	-0.1	-0.3	-0.4	-0.6	-0.6	1.4	-0.0	-0.9	0.1	-0.6
Qualifications: A levels/AS levels or equivalent	1.5	3.4	7.6	1.6	-2.3	1.8	1.7	2.1	2.8	2.2	0.8	1.5	-1.5	0.3	2.5	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	2.1	0.5	-0.4	0.4	-0.2	-0.1	-0.2	-0.5	0.7	0.4	0.1	-0.6	-1.5	0.3
Mouth/teeth dental problems: Dentures	0.3	0.6	1.6	-0.2	0.8	0.6	1.1	1.0	1.3	0.4	0.6	0.9	0.9	0.3	0.1	0.6
Asthma	0.7	1.4	6.4	-2.5	-2.3	-0.1	-0.3	-0.1	0.0	1.2	0.4	0.3	-1.9	-1.0	-0.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.4	0.2	0.8	-0.9	-1.2	-1.1	-1.0	-1.1	-0.6	-0.1	-0.6	-0.7	-0.1	-1.0
Medication: Cholesterol lowering	2.3	3.6	7.5	0.6	1.6	-2.1	-2.2	-2.3	-1.9	-1.7	-2.1	-1.2	-0.5	-2.7	-1.4	-2.6
Depression (self-reported)	3.6	4.3	9.3	-2.2	0.4	-2.8	-1.7	-1.8	-1.4	-3.1	-2.7	-2.3	-1.3	-1.5	-0.6	-2.9
Medication: Lansoprazole	2.6	3.0	6.4	-1.5	1.8	-2.3	-1.9	-2.0	-2.3	-1.0	-1.5	-0.3	0.1	-1.4	-2.5	-1.8
Prospective memory result	1.0	1.2	5.8	-0.9	2.4	0.3	1.3	1.2	1.2	1.2	0.3	1.0	1.4	0.2	0.1	0.4
Lung cancer (father)	2.1	2.4	5.3	-0.2	-0.1	1.6	1.6	1.6	1.7	2.3	1.7	2.2	0.2	0.8	1.9	1.9
Illnesses of mother	2.3	2.9	5.8	-2.4	-0.0	1.5	1.6	1.7	1.3	1.8	1.9	0.9	1.9	2.4	0.8	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	4.1	13.0	23.4	-2.8	-1.1	3.8	4.0	4.4	4.7	4.7	2.3	4.8	2.1	3.8	3.1	2.8
Pulse wave Arterial Stiffness index	0.3	0.3	1.8	0.7	-0.4	0.0	-0.3	-0.1	0.2	0.7	0.0	-0.1	-1.3	-1.0	-0.6	-0.2
Impedance of arm (left)	0.9	4.1	23.2	-1.1	4.8	-0.3	-0.9	-1.4	-2.5	-2.6	0.8	1.6	1.8	1.7	-2.0	0.7
Arm fat mass (right)	0.9	3.9	12.6	-0.1	-3.5	-0.8	1.2	1.5	3.1	0.5	-2.7	0.0	-2.4	-2.3	0.8	-2.2
Trunk predicted mass	16.4	93.7	222.0	0.4	-10.2	10.8	10.4	12.4	14.9	13.0	6.3	9.9	-2.0	4.4	11.3	7.5
Standing height	20.9	207.0	423.8	0.2	-11.3	17.0	15.4	18.0	20.6	18.6	11.5	17.2	-1.0	9.4	15.9	13.1
Length of working week for main job	0.5	0.5	3.2	-0.2	-0.9	0.3	-0.3	0.0	0.2	0.1	0.4	-0.3	-1.0	-1.8	-1.0	0.1
Exposure to tobacco smoke at home	0.9	1.0	4.5	-2.1	-0.4	-0.9	-1.3	-1.4	-1.6	-0.6	-0.3	0.0	0.0	-0.5	-0.7	-0.4
Breastfed as a baby	1.1	1.4	7.5	-2.7	1.1	-1.2	-1.4	-1.3	-1.8	-0.2	-0.3	0.1	0.1	-0.3	-0.8	-0.5
Tense / ‘highly strung’	0.8	1.4	6.0	-2.5	-1.0	-1.3	-0.2	-0.3	-0.4	-0.0	-1.5	0.9	-0.3	-0.5	-1.8	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	7.1	-1.3	-1.5	-2.3	-1.4	-1.3	-0.8	-0.9	-2.7	-1.0	-1.8	-1.9	-1.8	-2.6
Hair/balding pattern: Pattern 4	1.2	3.0	15.4	3.9	0.3	1.2	1.8	1.7	1.6	2.1	1.4	1.3	-1.1	1.2	0.6	1.4
Birth weight of first child	0.3	0.6	2.7	-1.3	1.6	-0.2	0.3	0.2	0.2	-0.6	-0.4	1.5	0.6	0.3	-0.0	-0.1
Peak expiratory flow (PEF)	6.5	15.1	28.3	-1.1	-3.3	4.4	4.1	4.7	5.3	4.9	2.8	4.9	0.1	3.2	4.2	3.6
Pulse wave reflection index	1.0	1.3	4.7	2.2	-0.9	-0.0	-1.2	-0.8	-0.7	0.6	0.1	-0.4	-1.2	-1.9	-1.7	-0.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	-1.0	0.8	-1.0	-1.2	-1.2	-1.4	-0.4	-0.7	0.8	0.1	-1.2	-1.5	-1.1
Loud music exposure frequency	1.1	1.2	6.4	-2.5	1.1	-1.2	1.0	0.7	0.8	-0.0	-1.5	0.8	-0.1	0.4	0.5	-0.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.7	-1.1	-2.4	-0.2	0.0	0.3	0.9	0.4	-0.5	0.1	-2.0	-1.0	1.9	-0.5
Mouth/teeth dental problems: Bleeding gums	4.9	6.4	11.9	-0.9	-0.1	-3.4	-2.7	-3.0	-2.6	-3.4	-3.4	-2.4	-1.7	-1.5	-1.0	-3.5
Blood clot in the leg (DVT)	10.4	13.4	32.1	0.3	-0.5	4.2	4.0	4.2	4.0	5.7	4.2	3.9	2.3	3.5	1.7	4.5
Medication: Paracetamol	1.8	3.0	7.3	-0.6	-0.0	-2.4	-1.8	-1.8	-1.6	-1.4	-1.8	-1.3	-0.1	-2.0	-2.7	-2.3
Headache pain in last month	0.3	0.5	2.6	-0.9	-0.3	0.6	-0.1	0.1	-0.1	0.9	0.5	0.3	1.6	-0.0	-1.3	0.0
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	5.3	-0.1	-1.0	1.6	2.0	2.1	1.8	1.8	1.4	1.1	0.0	2.3	1.0	2.0
Glaucoma (self-reported)	0.8	1.0	2.5	1.6	-0.2	1.4	0.3	0.4	0.4	-0.0	0.8	-0.5	1.5	1.3	1.5	0.9
Gout (self-reported)	0.1	0.1	0.4	-0.3	0.4	0.5	-0.1	-0.0	-0.1	0.3	0.1	0.4	-0.4	-0.6	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	7.4	-1.4	-2.7	-0.1	-0.1	-0.0	0.5	0.8	-0.9	0.5	-0.4	-0.7	0.5	-0.4
Medication: Amlodipine	0.6	0.8	5.3	-2.3	0.1	-0.5	-0.6	-0.7	-0.6	-1.0	-0.0	-0.3	-0.8	-1.2	0.7	0.0
Medication: Ventolin 100micrograms inhaler	1.3	1.7	10.8	-3.3	-1.1	-1.3	-0.9	-0.7	-0.5	0.1	-0.6	0.2	-1.7	-1.8	-0.4	-0.6
Birth weight	2.1	4.6	20.0	-1.1	0.8	2.4	1.5	1.7	1.7	3.0	2.2	4.5	1.1	1.7	1.0	2.2
Chronic bronchitis/emphysema (mother)	1.5	1.8	7.0	-0.4	2.0	-1.3	0.1	-0.2	-0.4	-0.0	-1.1	0.2	2.6	0.7	-2.4	-1.4
High blood pressure (siblings)	1.3	1.9	13.5	1.5	-3.7	-0.5	-0.8	-0.6	-0.1	1.0	-1.0	-1.1	-1.2	-1.0	0.3	-1.2
Forced vital capacity (FVC), Best measure	3.8	14.0	26.2	-3.2	-1.3	3.8	4.1	4.6	5.1	4.4	2.3	5.1	1.2	3.8	4.1	3.0
Body fat percentage	2.2	8.7	21.7	-0.1	-0.5	-3.8	-2.2	-2.4	-1.6	-3.2	-4.7	-2.7	-1.8	-3.9	-2.8	-4.5
Leg fat percentage (right)	6.2	22.4	40.3	0.9	0.0	-6.0	-4.6	-5.0	-4.4	-4.8	-6.2	-5.5	-2.2	-5.4	-4.7	-6.3
Arm fat-free mass (right)	12.2	62.5	153.8	0.4	-9.5	8.7	8.4	10.1	12.4	11.0	4.7	7.5	-1.8	2.8	8.9	5.6
Exposure to tobacco smoke outside home	1.8	2.4	6.5	-2.5	-1.0	-2.1	-1.6	-1.6	-1.5	-0.7	-1.6	-0.1	-1.3	-1.0	-1.5	-2.1
Comparative body size at age 10	1.1	2.9	10.6	0.1	-1.2	-2.1	-1.1	-1.4	-0.6	-1.5	-3.3	-0.9	-1.0	-2.1	-0.4	-3.0
Number of full brothers	4.1	5.2	11.9	-1.1	0.7	2.7	2.7	2.5	2.2	2.3	2.3	2.0	2.3	3.5	1.0	2.8
Worry too long after embarrassment	0.9	1.5	4.7	-0.9	-0.2	-1.7	-1.1	-1.1	-1.2	-0.3	-1.9	0.3	-0.7	-0.7	-1.5	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	6.2	-2.1	-0.4	-1.9	0.0	-0.0	0.6	-1.0	-2.5	-0.8	-0.9	-0.2	0.3	-2.2
Wheeze or whistling in the chest in last year	0.5	0.9	4.0	-2.0	-1.3	-0.9	-0.3	-0.1	-0.0	1.1	0.2	-0.1	-1.0	-1.1	-1.4	-0.1
Number of children fathered	0.8	0.9	2.6	1.4	1.0	-0.3	-1.1	-1.0	-0.8	-1.0	-0.4	0.4	-1.3	-1.6	-0.4	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	3.8	-0.2	-1.4	-0.6	-0.1	-0.2	-0.1	2.0	-0.5	0.9	-1.9	0.0	-0.7	0.0
Age at first live birth	0.3	0.6	3.6	1.9	-0.4	0.5	0.3	0.5	0.5	1.0	0.4	0.2	-0.9	0.7	0.7	0.3
Pulse wave peak to peak time	0.7	0.8	2.0	-0.6	-0.3	0.8	1.0	0.9	0.9	0.3	0.4	1.0	1.0	1.3	1.4	0.7
Health satisfaction	1.6	2.0	13.4	-1.0	-0.5	-1.3	-0.3	-0.2	-0.0	0.9	-1.1	0.2	-0.3	-2.4	-3.7	-1.5
Shortness of breath walking on level ground	2.3	2.7	6.3	-2.5	-1.4	-2.2	-1.0	-1.1	-0.7	-1.1	-2.1	-0.9	-0.4	-1.8	-2.1	-2.3
Qualifications: College or University degree	2.2	6.9	21.1	3.0	-1.6	3.3	2.1	2.7	2.6	4.6	2.8	1.6	-0.2	1.9	2.1	3.0
Eye problems/disorders: None of the above	0.9	1.1	2.1	0.3	0.8	1.3	1.4	1.5	1.3	0.1	1.1	0.8	0.8	1.3	0.3	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.6	1.6	-0.6	-0.0	0.4	0.3	0.7	0.1	-0.9	-0.1	-0.5	0.3	0.1	-0.6
Emphysema/chronic bronchitis	0.3	0.3	0.6	-0.6	0.6	-0.4	0.7	0.5	0.4	0.5	-0.2	0.8	0.6	0.6	0.6	-0.3
Medication for pain relief, constipation, heartburn	3.5	5.9	12.2	0.6	-0.5	3.3	2.5	2.5	2.1	2.4	2.9	1.5	0.7	3.3	2.9	3.5
Neck or shoulder pain in last month	0.6	0.8	3.5	0.4	-1.4	-0.7	-0.6	-0.6	-0.2	1.1	-0.8	-0.0	-1.9	-1.0	0.3	-0.8
Medication: Blood pressure	1.3	2.3	7.3	-0.4	-0.8	-1.7	-1.6	-1.6	-1.1	-1.7	-1.5	-1.2	-1.2	-2.7	-1.0	-2.0
Angina (self-reported)	2.2	2.9	9.3	0.3	-1.2	-2.3	-0.8	-0.7	-0.0	-0.6	-2.4	-1.2	-1.8	-3.0	-1.8	-2.6
Migraine (self-reported)	0.6	0.8	5.7	-1.1	-2.4	0.1	-0.7	-0.5	-0.5	-0.4	0.2	-1.1	0.7	0.4	0.7	0.1
Medication: Ibuprofen	0.4	0.5	1.2	0.1	-0.0	-0.7	-1.1	-1.0	-0.9	-0.8	-0.3	0.0	-0.9	-0.6	0.7	-0.7
Medication: Allopurinol	0.2	0.2	0.6	-0.2	0.5	-0.5	-0.3	-0.4	-0.3	-0.1	-0.7	0.0	-0.7	-0.6	-0.3	-0.8
Medication: Omeprazole	2.5	2.9	9.8	0.2	0.8	-1.1	-2.3	-2.2	-2.3	-1.0	-0.2	-0.6	-1.2	-2.7	-3.1	-0.8
Medication: Seretide 50 evohaler	0.5	0.6	1.6	-1.3	-0.9	0.0	-0.6	-0.5	-0.7	0.3	1.0	-0.3	-0.6	-0.6	-1.1	1.0
Mean time to correctly identify matches	0.8	1.6	9.2	1.3	1.5	-1.1	-0.9	-1.2	-1.1	-3.0	-0.6	-1.3	-0.8	-0.0	-0.4	-0.6
Heart disease (mother)	1.7	2.1	7.3	0.4	-0.6	-2.2	-0.7	-0.9	-0.3	-0.8	-2.5	-0.3	-1.3	-1.8	-1.3	-2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.9	0.1	0.6	0.6	1.1	1.0	0.9	0.5	0.4	0.0	0.8	1.7	0.9	1.1
Whole body fat mass	0.9	3.6	12.7	0.1	-3.6	-0.2	1.3	1.7	3.2	0.9	-2.3	0.6	-2.1	-2.0	0.9	-1.8
Leg fat mass (right)	1.2	4.8	13.5	0.8	-3.0	-2.0	-0.6	-0.4	0.9	-0.7	-3.7	-1.7	-2.6	-3.3	-0.5	-3.4
Arm predicted mass (right)	12.1	61.7	153.7	0.3	-9.5	8.6	8.3	10.1	12.4	10.7	4.5	7.4	-1.9	2.7	9.0	5.5
Pulse rate, automated reading	0.7	2.3	17.3	-4.2	1.2	-0.3	-0.4	-0.8	-1.2	-1.5	0.9	0.6	1.7	1.2	-0.2	1.1
Alcohol intake frequency.	0.7	1.6	4.0	-1.6	-0.6	-2.0	-1.4	-1.4	-1.5	-1.1	-1.1	-0.1	-0.7	-1.2	-1.0	-1.3
Comparative height size at age 10	14.0	77.0	185.0	-1.0	-8.4	9.7	9.5	11.1	13.6	9.6	5.2	11.2	-2.1	4.6	11.0	6.7
Number of full sisters	2.3	2.8	4.7	-1.0	-0.5	-2.2	-1.9	-2.1	-1.9	-1.4	-2.1	-1.5	-0.7	-1.6	-1.5	-2.2
Suffer from ‘nerves’	0.4	0.6	2.4	-1.5	-1.3	-0.9	-0.3	-0.3	-0.4	0.3	-1.0	0.2	-0.6	-0.6	-0.9	-0.7
Overall health rating	2.3	4.8	12.8	-1.9	-0.3	-3.4	-1.2	-1.4	-1.1	-0.9	-3.1	-1.1	-0.9	-2.9	-3.6	-3.0
Chest pain or discomfort	1.6	2.3	5.5	-1.2	-2.4	-1.4	-1.3	-1.1	-0.8	0.4	-1.4	-0.5	-2.2	-2.3	-1.9	-1.2
Had major operations	0.7	0.8	1.9	-1.4	0.3	-0.5	-1.2	-1.2	-1.3	-1.1	-0.3	0.2	1.3	0.0	-1.0	-0.4
Age at last live birth	1.2	1.7	3.9	1.4	-1.2	1.3	1.3	1.5	1.7	1.4	0.7	0.4	0.1	2.0	1.7	0.8
Family relationship satisfaction	0.3	0.4	1.0	0.6	-1.0	-0.7	-0.2	-0.0	0.3	-0.1	-0.8	-0.6	-0.7	-0.7	-0.3	-1.0
Leg pain on walking	0.8	1.0	5.0	-1.0	0.4	-0.4	-0.3	-0.4	-0.5	-0.2	-0.9	0.9	1.7	-0.8	-2.2	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.8	-1.0	1.3	-0.4	0.1	-0.1	0.0	-1.7	-0.1	1.0	0.3	-0.2	0.4	-0.5
Commuting to job workplace: Car/motor vehicle	1.8	2.0	4.8	-0.1	-0.1	-1.7	-1.1	-1.3	-0.9	-1.3	-2.2	-1.0	-1.8	-1.9	-1.3	-1.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.4	1.6	0.7	-0.5	-0.6	-0.6	-0.4	0.4	-0.8	-0.8	-1.0	-1.0	-0.0	-0.5
Medication: Aspirin	3.7	4.9	11.2	1.6	0.5	-3.0	-1.5	-1.7	-1.0	-2.1	-3.2	-2.2	-1.7	-2.9	-2.0	-3.4
Supplements: Vitamin C	1.5	1.7	3.8	-1.2	-1.1	0.7	1.8	1.7	1.9	1.0	0.6	1.5	0.4	1.6	1.3	1.0
Knee pain experienced in last month	6.6	10.3	18.3	-2.0	4.2	-4.3	-2.7	-3.4	-4.0	-2.9	-3.5	-2.0	1.2	-1.5	-4.3	-3.6
Hypertension (Self-reported)	1.5	4.1	8.0	-1.9	-2.1	-2.5	-1.6	-1.7	-0.9	-2.2	-2.5	-1.6	-2.0	-2.8	-0.1	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	4.1	-0.7	0.6	-0.9	-0.9	-1.0	-1.3	-0.1	-0.3	0.3	0.4	-1.4	-2.0	-0.4
Illnesses of father: Heart disease	3.1	4.2	9.9	0.7	-1.0	-2.3	-2.0	-2.0	-1.3	-2.0	-3.2	-1.6	-2.6	-2.6	0.0	-3.0
Illnesses of siblings: Diabetes	1.8	2.2	14.6	-0.6	-3.8	-0.9	-0.5	-0.5	-0.0	1.0	-1.2	-0.3	-2.5	-0.8	1.6	-0.7
Smoking status: Previous	1.1	1.6	3.9	-1.4	1.6	-0.9	-1.4	-1.6	-2.0	-1.8	-0.5	0.1	0.9	-0.7	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	11.9	24.6	68.9	-0.9	-3.0	4.9	6.5	7.1	8.3	5.8	3.0	5.2	-0.1	3.5	5.4	3.8
Whole body fat-free mass	15.0	85.6	216.1	0.4	-9.9	10.1	10.2	12.1	14.7	12.0	5.6	9.4	-2.1	3.9	10.9	6.8
Leg fat-free mass (right)	13.0	69.5	185.0	-0.3	-8.8	8.9	9.5	11.1	13.6	10.2	4.8	8.6	-1.9	3.4	10.0	5.8
Arm fat percentage (left)	2.3	9.0	23.0	-0.7	-0.6	-4.0	-2.1	-2.4	-1.6	-3.3	-4.8	-2.6	-1.7	-3.9	-2.8	-4.7
Average weekly red wine intake	1.0	1.5	4.1	1.2	-0.1	0.9	1.2	1.5	1.9	1.5	-0.3	1.2	-1.0	0.7	2.0	-0.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	4.7	-0.6	0.8	0.0	0.1	-0.0	-0.4	1.2	1.1	2.2	0.4	0.7	-0.3	0.9
Mood swings	0.7	1.3	6.7	-2.6	-1.0	-1.5	-0.2	-0.3	-0.3	-0.3	-1.6	-0.4	0.6	0.2	-0.8	-1.6
Loneliness, isolation	2.4	3.4	9.7	-2.0	-0.6	-2.8	-0.7	-1.0	-0.5	-2.3	-3.1	-1.1	-0.8	-1.2	-1.7	-3.0
Long-standing illness, disability or infirmity	1.4	2.1	5.1	-1.3	-0.9	-2.2	-0.7	-0.7	-0.2	1.2	-2.1	0.4	-1.2	-2.0	-1.6	-2.3
Ever had bowel cancer screening	0.8	0.9	1.9	-0.1	-1.1	-0.8	1.1	0.8	1.2	0.5	-1.4	1.0	0.1	0.3	1.3	-1.2
Diabetes diagnosed by doctor	0.3	0.4	2.1	-1.0	-1.5	-0.3	-0.4	-0.1	0.2	0.5	-0.5	-0.3	0.0	-1.0	-0.6	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.6	1.2	-0.6	-1.4	-0.3	-0.4	-0.2	-1.3	-1.5	-1.5	-0.3	0.1	-1.9	-1.7
Friendships satisfaction	1.4	1.8	4.3	0.2	-1.7	-1.7	-0.6	-0.7	-0.1	-1.1	-2.1	-1.8	-1.1	-1.6	-0.3	-1.9
Qualifications: nursing, teaching	0.4	0.6	2.3	0.4	-1.5	-0.8	-0.3	-0.2	0.1	0.3	-0.8	-0.9	-1.4	-0.7	0.2	-0.8
Commuting to job workplace: Walk	2.1	2.3	7.3	-0.2	-0.7	2.2	0.7	1.1	0.8	2.2	2.7	1.0	0.3	1.6	0.9	2.4
Eye problems/disorders: Cataract	0.5	0.6	3.1	0.4	-1.4	-0.5	-0.5	-0.4	-0.1	0.8	-0.5	-0.5	-0.8	-1.8	-0.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	4.7	-1.3	1.4	-1.7	-1.8	-2.0	-2.2	-1.9	-1.2	-1.1	0.3	-0.5	-1.8	-1.3
Medication for cholesterol	1.1	1.7	4.4	1.0	0.3	1.7	1.1	1.0	1.1	0.8	1.3	1.5	0.8	2.1	1.8	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	0.0	-0.0	-0.3	-0.4	-0.5	-0.3	-0.3	-0.9	0.4	-0.1	-0.8	-1.2	-1.0
Back pain experienced in last month	1.2	1.7	6.6	-1.0	2.4	0.9	1.0	0.7	0.6	0.9	0.5	2.6	1.8	1.3	0.2	0.5
Mineral and other dietary supplements	0.3	0.4	1.6	0.4	0.0	0.9	0.1	0.3	0.2	-0.5	0.9	0.1	1.3	-0.2	-0.9	0.7
Breast cancer (self-reported)	0.3	0.4	1.7	-1.3	-0.5	-0.8	-0.3	-0.2	-0.2	-0.4	-0.9	-0.2	-0.4	-0.5	0.1	-1.0
Asthma (self-reported)	0.7	1.5	8.3	-2.9	-2.3	-0.2	-0.3	-0.1	0.1	1.1	0.1	0.2	-1.9	-0.8	-0.4	0.3
Osteoporosis (self-reported)	0.2	0.3	1.3	-0.9	-0.1	0.7	-0.0	-0.2	-0.3	-0.5	0.2	0.5	1.2	0.4	-0.5	0.4
Osteoarthritis (self-reported)	2.2	2.8	7.6	-0.2	0.5	-2.4	-1.1	-1.5	-1.5	-1.7	-2.8	-1.1	1.1	-0.9	-2.0	-2.7
Medication: Aspirin	3.3	4.3	10.4	1.0	0.3	-2.9	-1.3	-1.5	-0.8	-1.9	-3.0	-1.7	-1.6	-3.0	-2.0	-3.2
Medication: Gliclazide	1.7	1.9	5.7	0.8	-1.7	1.2	1.9	1.9	2.4	0.9	0.3	0.4	-0.5	0.9	2.2	0.5
Illnesses of father: None of the above (group 1)	2.8	3.5	10.7	0.3	0.6	2.5	0.8	1.0	0.1	2.3	3.3	1.9	1.5	2.3	0.2	3.2
Smoking status: Current	0.5	0.8	5.4	-2.3	-0.0	-0.5	0.4	0.1	0.0	-0.6	-0.8	0.2	1.4	1.0	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	5.9	-2.4	2.1	-0.9	-0.8	-0.9	-1.5	-0.1	-0.8	0.6	1.4	0.6	-1.5	-0.7
Whole body water mass	14.6	83.5	210.2	0.2	-9.9	9.9	10.1	11.9	14.5	11.9	5.5	9.2	-2.1	3.7	10.8	6.6
Leg predicted mass (right)	13.0	69.4	185.0	-0.3	-8.7	8.9	9.5	11.1	13.6	10.1	4.8	8.6	-1.9	3.4	10.0	5.8
Arm fat mass (left)	0.9	3.5	12.7	-0.2	-3.6	-0.6	1.1	1.4	2.9	0.8	-2.6	0.2	-2.1	-2.3	0.5	-2.1
Number of self-reported non-cancer illnesses	1.1	2.0	8.6	-2.9	-2.2	-1.7	-0.2	-0.4	0.2	0.4	-2.0	0.3	-0.9	-1.2	-0.3	-1.6
Average weekly champagne plus white wine intake	0.3	0.4	2.0	0.6	-1.4	0.3	-0.4	-0.3	-0.1	0.6	0.4	0.8	-0.6	-0.4	-0.9	-0.1
Miserableness	1.1	1.8	5.5	-2.2	-0.3	-1.7	-0.7	-0.8	-0.6	-1.4	-2.4	-1.5	-0.2	0.0	-0.9	-2.0
Guilty feelings	1.8	2.8	10.0	-3.2	-1.4	-2.2	-1.3	-1.3	-1.2	0.5	-2.5	0.1	-0.6	-1.1	-0.4	-2.5
Wears glasses or contact lenses	0.4	0.5	1.1	0.9	1.1	0.7	-0.3	-0.0	-0.6	0.9	1.0	0.9	0.4	-0.3	-0.2	0.7
Ever taken oral contraceptive pill	0.7	0.8	1.6	0.9	0.9	-0.9	-1.0	-1.0	-1.3	-0.8	-0.5	-1.0	-1.2	0.6	-0.2	-0.7
Hearing aid user	1.6	1.8	5.7	1.4	2.4	1.4	0.4	0.4	-0.0	0.5	2.1	1.9	1.4	0.5	0.4	1.5
Mother’s age at death	0.6	0.8	4.3	2.1	0.9	-0.4	-0.7	-0.8	-1.0	-0.2	0.1	0.5	-1.0	-0.1	-1.1	-0.2
Financial situation satisfaction	1.1	1.4	6.6	-2.6	-0.0	-1.1	0.3	0.3	0.2	0.2	-1.2	0.7	0.8	-1.3	-1.9	-1.4
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.9	0.0	0.1	-0.0	-0.3	-0.2	-0.3	0.8	0.2	0.9	-0.2	-0.4	-0.5	0.0
Commuting to job workplace: Public transport	1.0	1.2	4.6	-0.9	-0.4	1.3	-0.0	0.2	-0.2	1.6	2.1	0.6	0.1	0.0	0.7	2.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	1.0	1.0	0.3	-0.7	-0.7	-0.8	-1.2	0.3	-1.3	0.8	0.1	0.9	0.2
Medication: Blood pressure	1.8	3.4	11.1	-1.8	-1.7	-2.0	-1.7	-1.5	-1.1	-0.8	-1.7	-1.8	-2.0	-3.3	-1.3	-1.8
Pain type(s) experienced in last month: Hip pain	3.2	4.1	9.8	0.2	-1.4	-2.5	-1.5	-1.7	-0.8	-1.2	-3.1	-1.8	-3.1	-2.5	0.3	-3.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.9	0.5	-0.7	-0.7	-0.6	-0.7	-0.7	0.5	-0.4	-0.3	-1.7	-0.2	0.5	-0.4
High cholesterol (Self-reported)	2.0	3.5	5.8	1.6	1.9	-2.0	-2.1	-2.2	-2.2	-2.0	-1.3	-2.3	-1.3	-2.4	-0.6	-1.3
Medication: Bendroflumethiazide	0.5	0.7	3.0	-1.6	-0.9	-0.5	-0.8	-0.7	-0.6	-0.4	-0.0	-0.7	-0.6	-1.7	-0.5	-0.1
Medication: Paracetamol	1.7	2.6	5.1	-0.3	-0.4	-2.2	-1.7	-1.7	-1.3	-1.5	-1.7	-1.3	-1.1	-2.1	-1.8	-2.3
Medication: Lisinopril	3.4	4.3	11.8	-1.0	-0.7	-2.7	-2.1	-2.1	-1.6	-1.6	-2.4	-1.5	-1.7	-3.4	-1.6	-2.8
Medication: Atorvastatin	1.1	1.4	5.7	-0.6	0.8	-1.2	-1.0	-1.0	-0.7	-0.4	-1.1	-0.5	-0.8	-2.4	-1.7	-1.3
Illnesses of father: High blood pressure	1.5	1.9	4.6	0.4	-0.8	-1.7	-1.1	-1.2	-0.7	-1.3	-1.4	-0.9	-1.0	-2.1	-1.8	-2.1
Alcohol drinker status: Never	0.5	0.6	2.7	-1.4	1.7	-0.5	-0.8	-0.8	-0.9	-0.6	0.2	-0.0	-0.1	0.2	0.5	0.1
Ever smoked	0.4	0.7	4.1	-2.0	0.4	-0.4	0.2	0.1	-0.2	-0.5	-0.6	0.6	1.7	1.0	-0.1	-0.6
Basal metabolic rate	12.5	69.2	182.2	0.2	-9.4	8.8	9.3	10.9	13.5	10.8	4.5	8.3	-2.3	3.1	9.8	5.6
Leg fat percentage (left)	5.8	20.9	36.5	0.4	-0.4	-5.9	-4.5	-4.8	-4.3	-4.5	-6.0	-5.3	-2.3	-5.2	-4.5	-6.0
Arm fat-free mass (left)	12.0	60.7	155.9	0.6	-9.1	8.4	8.5	10.2	12.5	10.5	4.3	7.5	-1.9	2.7	8.9	5.3
Number of operations (self-reported)	2.4	3.5	8.1	-2.3	-0.3	-2.3	-2.3	-2.4	-2.5	-1.6	-1.2	-0.9	-0.6	-1.5	-2.9	-1.4
Average weekly beer plus cider intake	0.4	0.6	1.4	-1.2	0.7	-0.5	-0.8	-0.9	-1.1	-0.7	-0.3	-0.8	0.6	0.2	-1.0	-0.2
Irritability	1.1	1.9	4.7	-0.3	-0.2	-1.6	-1.7	-1.5	-2.1	-0.5	-1.6	-0.9	0.5	-0.4	-1.7	-2.2
Risk taking	2.4	3.5	11.9	0.9	-1.5	1.5	3.1	3.0	3.5	1.7	0.2	0.9	0.4	1.4	1.7	0.9
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.7	-0.8	0.0	-0.6	-0.4	-0.4	0.7	0.0	0.5	-0.7	0.0	0.5	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	1.2	-0.1	1.1	0.6	0.5	0.5	0.4	-0.7	0.5	-0.2	0.6	1.0	0.5	0.5
Age started oral contraceptive pill	2.2	2.7	9.1	-0.3	0.9	1.6	1.6	1.7	1.0	3.0	1.8	2.3	0.8	1.4	1.1	2.0
Diastolic blood pressure, automated reading	0.5	1.7	5.8	-1.8	-2.4	-1.1	-0.4	-0.5	-0.0	-1.6	-1.6	-1.1	-1.1	-0.9	1.1	-1.0
Ever depressed for a whole week	0.2	0.2	0.5	-0.6	0.6	-0.7	-0.1	-0.2	-0.1	-0.3	-0.7	0.2	-0.7	0.2	-0.6	-0.6
Unable to work because of sickness or disability	0.8	1.1	2.5	-1.5	0.9	-1.6	0.4	0.2	0.3	-1.3	-1.5	-0.4	0.8	0.3	-1.1	-1.5
Commuting to job workplace: Cycle	3.3	4.0	7.8	0.4	-0.1	2.5	2.3	2.4	2.4	1.0	1.9	1.5	2.0	2.4	2.8	2.0
Myopia	0.6	0.8	3.4	0.1	-0.6	1.3	-0.3	0.2	0.0	1.1	1.9	0.7	-0.3	-1.1	0.1	1.3
Vascular/heart problems diagnosed by doctor	2.5	6.8	13.6	2.0	2.4	3.4	2.2	2.1	1.2	2.1	3.3	2.5	2.5	3.7	1.5	3.5
Cholesterol lowering medication	1.4	2.0	7.6	0.4	1.4	-1.7	-1.1	-1.0	-0.9	-0.8	-1.3	-1.3	-1.5	-2.8	-1.6	-1.3
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	7.2	0.2	0.6	-1.5	-2.0	-2.0	-1.9	-1.3	-0.8	-0.8	-1.5	-2.7	-2.6	-1.2
Pain experienced in last month	0.9	1.4	3.7	1.3	-1.1	1.2	1.6	1.8	1.9	1.1	0.6	0.1	-0.2	0.7	1.2	1.1
Supplements: Calcium	0.4	0.5	2.1	-1.5	0.1	-0.7	0.5	0.4	0.8	-0.3	-0.8	0.1	-0.6	-0.2	0.9	-0.9
Basal cell carcinoma (self-reported)	1.2	1.4	6.7	0.9	-0.5	-0.8	-1.3	-1.3	-1.4	-1.1	-0.4	1.1	-2.6	-1.0	-0.9	-0.6
Heart attack/myocardial infarction (self-reported)	4.4	5.7	13.7	-1.3	-0.3	-3.2	-2.4	-2.5	-2.1	-1.0	-2.6	-0.6	-2.2	-3.7	-3.1	-3.0
Deep venous thrombosis (DVT) (self-reported)	11.8	15.2	35.4	0.4	-0.5	4.7	4.2	4.4	4.1	6.0	4.5	4.2	2.5	3.9	1.7	4.9
Heart disease (siblings)	0.8	1.0	3.6	-1.2	-1.2	-1.3	-0.3	-0.5	-0.1	-0.1	-1.9	0.7	-0.8	-0.2	0.9	-1.7
Alcohol drinker status: Previous	0.2	0.3	0.9	0.0	-0.6	0.2	0.0	0.1	0.1	1.0	0.7	0.4	-0.5	-0.7	0.1	0.7
Pack years of smoking	1.1	1.7	5.2	-0.9	-1.0	0.6	1.4	1.3	1.5	2.0	0.5	2.3	1.1	1.5	-0.3	0.8
Impedance of whole body	1.5	7.7	26.4	-0.5	5.1	-1.9	-2.7	-3.3	-4.7	-3.6	-0.3	-0.5	1.5	0.7	-3.8	-0.4
Leg fat mass (left)	1.2	4.6	12.1	0.5	-3.5	-1.9	-0.5	-0.3	1.0	-0.4	-3.5	-1.5	-2.6	-3.2	-0.4	-3.2
Arm predicted mass (left)	12.2	62.2	161.3	0.5	-9.3	8.3	8.7	10.3	12.7	10.6	4.3	7.3	-2.1	2.8	9.2	5.4