TWAS hub - EIF6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.3230	0.0990	1.3e-03	0.021	NA	0.070	NA	0.081	8.0e-02	NA	4.8e-03	NA	2.5e-03
2	GTEx	Brain Hippocampus	0.4048	0.1350	1.2e-03	-0.004	NA	-0.012	NA	0.052	4.2e-01	NA	7.8e-01	NA	2.4e-02
3	GTEx	Lung	0.1967	0.0650	2.2e-05	0.102	NA	0.081	NA	0.087	3.2e-08	NA	9.1e-07	NA	3.4e-07
4	GTEx	Muscle Skeletal	0.3177	0.0531	0.0e+00	0.251	NA	0.249	NA	0.266	1.6e-24	NA	2.8e-24	NA	4.6e-26
5	GTEx	Skin Not Sun Exposed Suprapubic	0.3240	0.0850	1.6e-05	0.113	NA	0.035	NA	0.070	9.0e-07	NA	5.1e-03	NA	1.1e-04
6	GTEx	Skin Sun Exposed Lower leg	0.4000	0.0770	2.5e-13	0.210	NA	0.158	NA	0.190	3.0e-17	NA	4.4e-13	NA	1.2e-15
7	METSIM	Adipose	0.0719	0.0293	1.0e-06	0.022	0.043	0.032	0.044	0.040	2.6e-04	4.2e-07	1.2e-05	2.7e-07	9.1e-07
8	NTR	Blood	0.0698	0.0243	2.3e-12	0.053	0.042	0.049	0.047	0.051	1.4e-16	2.0e-13	1.5e-15	6.7e-15	4.1e-16
9	YFS	Blood	0.0194	0.0087	5.3e-05	0.004	0.012	0.008	0.012	0.006	1.6e-02	4.1e-05	7.6e-04	4.3e-05	2.7e-03
10	TCGA	Glioblastoma Multiforme	0.1590	0.0880	9.5e-03	0.038	0.056	0.009	NA	0.043	2.6e-02	8.6e-03	1.7e-01	NA	1.9e-02
11	TCGA	Head and Neck Squamous Cell Carcinoma	0.0340	0.0202	3.3e-03	0.025	0.026	0.030	NA	0.018	6.8e-04	5.4e-04	2.4e-04	NA	3.6e-03
12	TCGA	Brain Lower Grade Glioma	0.2028	0.0985	1.2e-06	0.014	0.030	0.043	NA	0.036	9.7e-03	2.3e-04	1.1e-05	NA	5.2e-05
13	TCGA	Pancreatic Adenocarcinoma	0.3070	0.1110	1.4e-04	0.109	0.074	0.038	NA	0.081	2.5e-05	5.0e-04	1.0e-02	NA	2.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Sitting height	24.6	174.6	416.2	3.1	-11.5	15.6	14.7	17.4	20.4	17.4	9.9	13.5	-2.7	6.4	13.8	11.3
Standing height	20.9	207.0	423.8	0.2	-11.3	17.0	15.4	18.0	20.6	18.6	11.5	17.2	-1.0	9.4	15.9	13.1
Height	19.6	377.3	800.9	-1.6	-16.6	22.4	20.9	24.4	28.3	25.6	14.3	23.8	-1.7	11.6	21.2	16.7
Trunk fat-free mass	16.4	94.1	222.0	0.5	-10.2	10.8	10.5	12.4	14.9	13.0	6.3	9.9	-2.1	4.4	11.4	7.5
Trunk predicted mass	16.4	93.7	222.0	0.4	-10.2	10.8	10.4	12.4	14.9	13.0	6.3	9.9	-2.0	4.4	11.3	7.5
Tanning	15.2	185.2	552.2	8.2	-10.8	15.2	16.4	17.9	23.5	14.8	11.1	-6.3	5.7	8.2	14.1	13.1
Whole body fat-free mass	15.0	85.6	216.1	0.4	-9.9	10.1	10.2	12.1	14.7	12.0	5.6	9.4	-2.1	3.9	10.9	6.8
Whole body water mass	14.6	83.5	210.2	0.2	-9.9	9.9	10.1	11.9	14.5	11.9	5.5	9.2	-2.1	3.7	10.8	6.6
Hand grip strength (right)	14.0	38.1	79.0	2.3	-4.7	7.5	6.9	7.9	8.9	7.3	4.8	6.3	-0.7	4.2	7.4	5.7
Comparative height size at age 10	14.0	77.0	185.0	-1.0	-8.4	9.7	9.5	11.1	13.6	9.6	5.2	11.2	-2.1	4.6	11.0	6.7
Leg fat-free mass (right)	13.0	69.5	185.0	-0.3	-8.8	8.9	9.5	11.1	13.6	10.2	4.8	8.6	-1.9	3.4	10.0	5.8
Leg predicted mass (right)	13.0	69.4	185.0	-0.3	-8.7	8.9	9.5	11.1	13.6	10.1	4.8	8.6	-1.9	3.4	10.0	5.8
Basal metabolic rate	12.5	69.2	182.2	0.2	-9.4	8.8	9.3	10.9	13.5	10.8	4.5	8.3	-2.3	3.1	9.8	5.6
Leg predicted mass (left)	12.3	65.0	179.6	0.1	-8.4	8.5	9.3	10.8	13.4	9.8	4.3	8.2	-2.0	3.1	9.7	5.3
Arm fat-free mass (right)	12.2	62.5	153.8	0.4	-9.5	8.7	8.4	10.1	12.4	11.0	4.7	7.5	-1.8	2.8	8.9	5.6
Arm predicted mass (left)	12.2	62.2	161.3	0.5	-9.3	8.3	8.7	10.3	12.7	10.6	4.3	7.3	-2.1	2.8	9.2	5.4
Arm predicted mass (right)	12.1	61.7	153.7	0.3	-9.5	8.6	8.3	10.1	12.4	10.7	4.5	7.4	-1.9	2.7	9.0	5.5
Leg fat-free mass (left)	12.0	63.5	174.2	0.1	-8.5	8.3	9.2	10.7	13.2	9.7	4.2	8.2	-2.1	2.9	9.6	5.2
Arm fat-free mass (left)	12.0	60.7	155.9	0.6	-9.1	8.4	8.5	10.2	12.5	10.5	4.3	7.5	-1.9	2.7	8.9	5.3
Hand grip strength (left)	11.9	31.3	64.0	3.0	-3.5	6.7	6.4	7.1	8.0	6.3	4.5	6.0	-0.4	3.8	6.9	5.2
Forced expiratory volume in 1-second (FEV1), predicted	11.9	24.6	68.9	-0.9	-3.0	4.9	6.5	7.1	8.3	5.8	3.0	5.2	-0.1	3.5	5.4	3.8
Deep venous thrombosis (DVT) (self-reported)	11.8	15.2	35.4	0.4	-0.5	4.7	4.2	4.4	4.1	6.0	4.5	4.2	2.5	3.9	1.7	4.9
Blood clot in the leg (DVT)	10.4	13.4	32.1	0.3	-0.5	4.2	4.0	4.2	4.0	5.7	4.2	3.9	2.3	3.5	1.7	4.5
Ulcerative Colitis	6.7	9.7	18.5	-0.7	-2.9	3.5	3.7	3.9	3.8	4.3	2.7	2.3	1.1	2.8	3.0	3.5
Knee pain experienced in last month	6.6	10.3	18.3	-2.0	4.2	-4.3	-2.7	-3.4	-4.0	-2.9	-3.5	-2.0	1.2	-1.5	-4.3	-3.6
Peak expiratory flow (PEF)	6.5	15.1	28.3	-1.1	-3.3	4.4	4.1	4.7	5.3	4.9	2.8	4.9	0.1	3.2	4.2	3.6
Leg fat percentage (right)	6.2	22.4	40.3	0.9	0.0	-6.0	-4.6	-5.0	-4.4	-4.8	-6.2	-5.5	-2.2	-5.4	-4.7	-6.3
Ulcerative Colitis (UC)	5.9	11.1	24.8	0.1	-2.4	3.6	4.2	4.4	4.2	5.0	2.9	2.5	1.2	3.3	2.7	3.6
Hair Pigment	5.9	167.0	558.6	-9.6	11.3	-14.0	-15.3	-16.9	-23.6	-13.3	-8.6	9.4	-4.8	-4.7	-13.4	-10.6
Leg fat percentage (left)	5.8	20.9	36.5	0.4	-0.4	-5.9	-4.5	-4.8	-4.3	-4.5	-6.0	-5.3	-2.3	-5.2	-4.5	-6.0
Heart attack	5.3	6.8	16.0	-1.0	-0.5	-3.5	-2.6	-2.6	-2.2	-1.3	-3.0	-1.0	-2.4	-4.0	-3.3	-3.4
Mouth/teeth dental problems: Bleeding gums	4.9	6.4	11.9	-0.9	-0.1	-3.4	-2.7	-3.0	-2.6	-3.4	-3.4	-2.4	-1.7	-1.5	-1.0	-3.5
Weight	4.8	23.6	73.5	0.1	-7.2	4.3	5.2	6.3	8.6	5.9	0.9	4.6	-2.7	0.2	5.4	1.7
Heart attack/myocardial infarction (self-reported)	4.4	5.7	13.7	-1.3	-0.3	-3.2	-2.4	-2.5	-2.1	-1.0	-2.6	-0.6	-2.2	-3.7	-3.1	-3.0
Lung FVC	4.1	20.8	46.6	-5.5	5.6	-5.7	-4.5	-5.6	-6.8	-5.1	-3.6	-2.4	1.3	-0.7	-3.9	-3.9
Forced expiratory volume in 1-second (FEV1), Best measure	4.1	13.0	23.4	-2.8	-1.1	3.8	4.0	4.4	4.7	4.7	2.3	4.8	2.1	3.8	3.1	2.8
Number of full brothers	4.1	5.2	11.9	-1.1	0.7	2.7	2.7	2.5	2.2	2.3	2.3	2.0	2.3	3.5	1.0	2.8
Forced vital capacity (FVC), Best measure	3.8	14.0	26.2	-3.2	-1.3	3.8	4.1	4.6	5.1	4.4	2.3	5.1	1.2	3.8	4.1	3.0
Medication: Aspirin	3.7	4.9	11.2	1.6	0.5	-3.0	-1.5	-1.7	-1.0	-2.1	-3.2	-2.2	-1.7	-2.9	-2.0	-3.4
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.7	12.8	-2.5	-2.0	-3.2	-2.3	-2.5	-2.2	-2.1	-3.4	-0.7	-1.4	-1.3	-2.0	-3.6
Depression (self-reported)	3.6	4.3	9.3	-2.2	0.4	-2.8	-1.7	-1.8	-1.4	-3.1	-2.7	-2.3	-1.3	-1.5	-0.6	-2.9
Irritable Bowel Disease (IBD)	3.5	8.3	14.1	-0.1	-1.5	3.2	3.5	3.8	3.6	3.3	2.9	1.8	1.2	3.0	3.4	3.3
Medication for pain relief, constipation, heartburn	3.5	5.9	12.2	0.6	-0.5	3.3	2.5	2.5	2.1	2.4	2.9	1.5	0.7	3.3	2.9	3.5
Medication: Lisinopril	3.4	4.3	11.8	-1.0	-0.7	-2.7	-2.1	-2.1	-1.6	-1.6	-2.4	-1.5	-1.7	-3.4	-1.6	-2.8
Medication: Aspirin	3.3	4.3	10.4	1.0	0.3	-2.9	-1.3	-1.5	-0.8	-1.9	-3.0	-1.7	-1.6	-3.0	-2.0	-3.2
Commuting to job workplace: Cycle	3.3	4.0	7.8	0.4	-0.1	2.5	2.3	2.4	2.4	1.0	1.9	1.5	2.0	2.4	2.8	2.0
Pain type(s) experienced in last month: Hip pain	3.2	4.1	9.8	0.2	-1.4	-2.5	-1.5	-1.7	-0.8	-1.2	-3.1	-1.8	-3.1	-2.5	0.3	-3.0
Vitamin and mineral supplements	3.1	4.2	9.7	0.4	1.3	-1.5	-3.0	-2.9	-3.0	-3.1	-1.3	-2.1	-1.0	-2.0	-1.1	-1.7
Illnesses of father: Heart disease	3.1	4.2	9.9	0.7	-1.0	-2.3	-2.0	-2.0	-1.3	-2.0	-3.2	-1.6	-2.6	-2.6	0.0	-3.0
Lupus	3.0	4.5	8.7	1.6	1.2	3.0	2.1	2.3	2.0	2.2	2.6	2.3	1.6	2.4	1.1	2.4
Forced vital capacity (FVC)	3.0	11.5	19.8	-3.8	-1.4	3.0	3.5	3.9	4.4	4.0	1.7	4.4	0.5	3.6	4.3	2.4
Lung FEV1/FVC ratio	2.9	14.5	40.4	0.8	-2.2	5.0	3.6	4.1	4.1	6.4	3.6	5.0	2.5	3.0	1.9	3.9
Forced expiratory volume in 1-second (FEV1)	2.9	9.6	18.3	-3.7	-1.6	2.8	3.1	3.5	3.9	4.3	1.5	4.2	1.0	3.2	3.1	2.0
Impedance of leg (right)	2.8	13.7	40.4	0.9	4.5	-3.5	-4.3	-5.0	-6.4	-4.1	-1.7	-3.2	1.1	-0.5	-5.1	-2.0
Fed-up feelings	2.8	5.1	13.8	-1.6	-0.5	-3.3	-1.4	-1.4	-1.0	-1.3	-3.7	-2.2	-0.3	-2.0	-3.2	-3.7
Impedance of leg (left)	2.8	13.6	42.1	0.2	4.2	-3.5	-4.4	-5.0	-6.5	-4.1	-1.6	-3.3	1.0	-0.3	-4.9	-1.8
Illnesses of father: None of the above (group 1)	2.8	3.5	10.7	0.3	0.6	2.5	0.8	1.0	0.1	2.3	3.3	1.9	1.5	2.3	0.2	3.2
Multivitamins +/- minerals	2.6	3.3	9.8	0.4	-0.8	1.3	2.8	2.8	3.1	3.0	1.1	1.3	0.3	0.8	0.5	1.3
Medication: Lansoprazole	2.6	3.0	6.4	-1.5	1.8	-2.3	-1.9	-2.0	-2.3	-1.0	-1.5	-0.3	0.1	-1.4	-2.5	-1.8
Medication: Omeprazole	2.5	2.9	9.8	0.2	0.8	-1.1	-2.3	-2.2	-2.3	-1.0	-0.2	-0.6	-1.2	-2.7	-3.1	-0.8
Vascular/heart problems diagnosed by doctor	2.5	6.8	13.6	2.0	2.4	3.4	2.2	2.1	1.2	2.1	3.3	2.5	2.5	3.7	1.5	3.5
Age when periods started (menarche)	2.4	5.9	12.4	0.1	3.3	2.4	0.9	1.0	-0.4	3.5	3.5	1.8	3.5	2.9	-0.7	2.9
Loneliness, isolation	2.4	3.4	9.7	-2.0	-0.6	-2.8	-0.7	-1.0	-0.5	-2.3	-3.1	-1.1	-0.8	-1.2	-1.7	-3.0
Number of operations (self-reported)	2.4	3.5	8.1	-2.3	-0.3	-2.3	-2.3	-2.4	-2.5	-1.6	-1.2	-0.9	-0.6	-1.5	-2.9	-1.4
Risk taking	2.4	3.5	11.9	0.9	-1.5	1.5	3.1	3.0	3.5	1.7	0.2	0.9	0.4	1.4	1.7	0.9
Supplements: Zinc	2.3	2.5	6.6	0.0	-1.5	1.1	1.9	2.1	2.6	1.5	1.4	-0.0	-1.2	0.7	2.3	1.6
Hip circumference	2.3	10.1	37.6	0.7	-6.1	1.9	2.9	3.6	5.6	2.8	-0.9	1.9	-3.2	-1.2	3.5	-0.3
Medication: Cholesterol lowering	2.3	3.6	7.5	0.6	1.6	-2.1	-2.2	-2.3	-1.9	-1.7	-2.1	-1.2	-0.5	-2.7	-1.4	-2.6
Illnesses of mother	2.3	2.9	5.8	-2.4	-0.0	1.5	1.6	1.7	1.3	1.8	1.9	0.9	1.9	2.4	0.8	2.1
Shortness of breath walking on level ground	2.3	2.7	6.3	-2.5	-1.4	-2.2	-1.0	-1.1	-0.7	-1.1	-2.1	-0.9	-0.4	-1.8	-2.1	-2.3
Number of full sisters	2.3	2.8	4.7	-1.0	-0.5	-2.2	-1.9	-2.1	-1.9	-1.4	-2.1	-1.5	-0.7	-1.6	-1.5	-2.2
Overall health rating	2.3	4.8	12.8	-1.9	-0.3	-3.4	-1.2	-1.4	-1.1	-0.9	-3.1	-1.1	-0.9	-2.9	-3.6	-3.0
Arm fat percentage (left)	2.3	9.0	23.0	-0.7	-0.6	-4.0	-2.1	-2.4	-1.6	-3.3	-4.8	-2.6	-1.7	-3.9	-2.8	-4.7
Number of treatments/medications taken	2.2	4.0	11.0	-3.3	-1.4	-2.7	-1.5	-1.5	-0.9	-0.3	-2.4	-0.1	-1.9	-3.2	-0.9	-2.3
Medication: Ramipril	2.2	2.8	8.7	-0.9	1.2	-2.0	-1.7	-1.5	-1.4	-0.7	-1.3	-1.0	-0.3	-3.0	-2.6	-2.0
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	11.0	-0.9	-2.1	-2.3	-0.7	-0.6	0.3	-0.4	-3.3	-0.7	-2.6	-2.3	-1.4	-3.1
Body fat percentage	2.2	8.7	21.7	-0.1	-0.5	-3.8	-2.2	-2.4	-1.6	-3.2	-4.7	-2.7	-1.8	-3.9	-2.8	-4.5
Qualifications: College or University degree	2.2	6.9	21.1	3.0	-1.6	3.3	2.1	2.7	2.6	4.6	2.8	1.6	-0.2	1.9	2.1	3.0
Angina (self-reported)	2.2	2.9	9.3	0.3	-1.2	-2.3	-0.8	-0.7	-0.0	-0.6	-2.4	-1.2	-1.8	-3.0	-1.8	-2.6
Osteoarthritis (self-reported)	2.2	2.8	7.6	-0.2	0.5	-2.4	-1.1	-1.5	-1.5	-1.7	-2.8	-1.1	1.1	-0.9	-2.0	-2.7
Age started oral contraceptive pill	2.2	2.7	9.1	-0.3	0.9	1.6	1.6	1.7	1.0	3.0	1.8	2.3	0.8	1.4	1.1	2.0
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	7.2	0.2	0.6	-1.5	-2.0	-2.0	-1.9	-1.3	-0.8	-0.8	-1.5	-2.7	-2.6	-1.2
Major Depression (MDD)	2.1	2.5	6.1	-1.3	-0.4	-2.5	-1.3	-1.4	-1.1	-0.5	-2.4	-1.8	-1.2	-1.4	-1.5	-2.2
Waist Hip Ratio (WHR)	2.1	9.3	22.3	-4.4	3.9	-2.9	-2.9	-3.4	-4.7	-2.7	-0.6	-1.8	3.3	-0.1	-3.7	-1.1
Angina	2.1	2.8	8.4	0.1	-0.7	-2.3	-0.7	-0.7	-0.1	-0.8	-2.4	-1.1	-1.5	-2.9	-2.0	-2.7
Arm fat percentage (right)	2.1	8.3	22.6	-0.6	-0.7	-4.0	-1.7	-2.0	-1.2	-3.0	-4.8	-2.4	-2.0	-3.8	-2.5	-4.5
Lung cancer (father)	2.1	2.4	5.3	-0.2	-0.1	1.6	1.6	1.6	1.7	2.3	1.7	2.2	0.2	0.8	1.9	1.9
Birth weight	2.1	4.6	20.0	-1.1	0.8	2.4	1.5	1.7	1.7	3.0	2.2	4.5	1.1	1.7	1.0	2.2
Commuting to job workplace: Walk	2.1	2.3	7.3	-0.2	-0.7	2.2	0.7	1.1	0.8	2.2	2.7	1.0	0.3	1.6	0.9	2.4
Chronotype (morning person)	2.0	4.7	9.7	-1.3	-0.7	1.9	2.4	2.5	2.3	3.0	2.4	3.1	0.7	1.9	1.6	2.5
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	15.0	3.6	-2.0	-1.0	-1.8	-1.5	-1.0	-0.5	-1.3	-2.3	-3.9	-3.1	-0.7	-1.4
Hair/balding pattern: Pattern 2	2.0	2.5	7.5	-0.7	0.2	-2.1	-1.3	-1.5	-1.5	-1.3	-2.7	-0.9	-0.6	-1.8	-1.4	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	7.1	-1.3	-1.5	-2.3	-1.4	-1.3	-0.8	-0.9	-2.7	-1.0	-1.8	-1.9	-1.8	-2.6
High cholesterol (Self-reported)	2.0	3.5	5.8	1.6	1.9	-2.0	-2.1	-2.2	-2.2	-2.0	-1.3	-2.3	-1.3	-2.4	-0.6	-1.3
Frequency of depressed mood in last 2 weeks	1.9	2.6	7.7	-2.1	-1.0	-2.4	-0.9	-1.0	-0.6	-1.3	-2.7	-0.7	-0.6	-1.0	-1.5	-2.8
Relative age voice broke	1.9	2.8	11.8	0.1	2.8	-1.0	-2.2	-2.4	-3.4	-0.7	0.4	-0.4	1.4	-0.6	-1.7	-0.2
Body mass index (BMI)	1.9	8.1	19.6	0.1	-2.5	-3.4	-1.7	-1.7	-0.5	-2.3	-4.4	-3.2	-2.5	-4.2	-1.7	-4.3
Mouth/teeth dental problems	1.9	2.9	7.3	1.2	-1.4	2.5	1.1	1.4	1.1	2.5	2.7	1.4	-0.1	0.5	1.4	2.5
Age at First Birth	1.8	2.6	9.1	1.4	-0.1	1.8	1.6	1.8	1.5	3.0	1.7	1.8	-0.1	1.3	0.5	2.0
Townsend deprivation index at recruitment	1.8	2.5	6.4	-2.5	0.5	-1.8	-1.4	-1.6	-1.9	-1.2	-1.6	-1.2	1.1	-0.5	-2.0	-1.8
Medication: Paracetamol	1.8	3.0	7.3	-0.6	-0.0	-2.4	-1.8	-1.8	-1.6	-1.4	-1.8	-1.3	-0.1	-2.0	-2.7	-2.3
Exposure to tobacco smoke outside home	1.8	2.4	6.5	-2.5	-1.0	-2.1	-1.6	-1.6	-1.5	-0.7	-1.6	-0.1	-1.3	-1.0	-1.5	-2.1
Commuting to job workplace: Car/motor vehicle	1.8	2.0	4.8	-0.1	-0.1	-1.7	-1.1	-1.3	-0.9	-1.3	-2.2	-1.0	-1.8	-1.9	-1.3	-1.9
Illnesses of siblings: Diabetes	1.8	2.2	14.6	-0.6	-3.8	-0.9	-0.5	-0.5	-0.0	1.0	-1.2	-0.3	-2.5	-0.8	1.6	-0.7
Guilty feelings	1.8	2.8	10.0	-3.2	-1.4	-2.2	-1.3	-1.3	-1.2	0.5	-2.5	0.1	-0.6	-1.1	-0.4	-2.5
Medication: Blood pressure	1.8	3.4	11.1	-1.8	-1.7	-2.0	-1.7	-1.5	-1.1	-0.8	-1.7	-1.8	-2.0	-3.3	-1.3	-1.8
Crohns Disease (2012)	1.7	2.7	5.8	0.7	-0.8	2.1	1.6	1.8	1.5	0.6	2.1	0.7	0.9	2.2	2.4	2.2
Systolic blood pressure, automated reading	1.7	5.0	8.8	2.6	-3.0	2.3	2.1	2.4	2.7	2.3	1.6	1.5	-1.5	0.6	2.9	2.2
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	7.0	-0.3	0.4	1.1	1.8	1.9	1.8	2.6	1.9	0.0	-0.7	1.4	0.9	2.1
Illnesses of siblings	1.7	2.3	15.8	-0.4	4.0	1.0	1.0	0.9	0.4	-0.8	1.3	0.6	2.2	1.2	-0.9	1.2
Heart disease (mother)	1.7	2.1	7.3	0.4	-0.6	-2.2	-0.7	-0.9	-0.3	-0.8	-2.5	-0.3	-1.3	-1.8	-1.3	-2.7
Medication: Gliclazide	1.7	1.9	5.7	0.8	-1.7	1.2	1.9	1.9	2.4	0.9	0.3	0.4	-0.5	0.9	2.2	0.5
Medication: Paracetamol	1.7	2.6	5.1	-0.3	-0.4	-2.2	-1.7	-1.7	-1.3	-1.5	-1.7	-1.3	-1.1	-2.1	-1.8	-2.3
Bipolar Disorder (2011)	1.6	1.6	8.5	2.9	-0.5	1.3	1.2	1.2	1.6	1.1	1.3	-0.4	-0.4	-0.0	0.8	0.0
Rheumatoid Arthritis	1.6	2.1	11.2	-3.3	2.1	0.8	0.6	0.8	0.3	0.4	1.4	1.1	2.3	1.1	0.3	1.0
Systolic Blood Pressure	1.6	7.9	20.1	1.4	-3.8	3.0	2.9	3.2	3.7	2.0	2.4	1.5	-1.4	1.7	4.5	2.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	10.7	-3.3	-0.4	-1.7	-0.7	-1.0	-1.0	0.7	-2.1	1.2	0.6	-0.4	-0.7	-1.8
Happiness	1.6	2.0	5.2	-0.8	-0.3	-2.3	-0.7	-0.7	-0.5	-1.1	-2.2	-1.0	-0.1	-1.6	-2.0	-2.3
Health satisfaction	1.6	2.0	13.4	-1.0	-0.5	-1.3	-0.3	-0.2	-0.0	0.9	-1.1	0.2	-0.3	-2.4	-3.7	-1.5
Chest pain or discomfort	1.6	2.3	5.5	-1.2	-2.4	-1.4	-1.3	-1.1	-0.8	0.4	-1.4	-0.5	-2.2	-2.3	-1.9	-1.2
Hearing aid user	1.6	1.8	5.7	1.4	2.4	1.4	0.4	0.4	-0.0	0.5	2.1	1.9	1.4	0.5	0.4	1.5
Prostate Cancer	1.5	2.0	5.5	-1.6	1.9	-1.1	-1.7	-1.7	-2.3	-0.8	-0.7	-0.8	1.7	0.1	-1.7	-0.8
Medication: Simvastatin	1.5	2.1	6.9	1.1	2.6	-1.5	-1.3	-1.4	-1.2	-1.6	-0.8	-0.5	-1.0	-2.3	-1.1	-1.2
Pulse rate	1.5	2.6	12.4	-3.5	1.7	0.2	1.2	0.7	0.3	-0.1	0.9	0.9	2.3	2.6	0.2	1.4
Qualifications: A levels/AS levels or equivalent	1.5	3.4	7.6	1.6	-2.3	1.8	1.7	2.1	2.8	2.2	0.8	1.5	-1.5	0.3	2.5	0.9
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	5.3	-0.1	-1.0	1.6	2.0	2.1	1.8	1.8	1.4	1.1	0.0	2.3	1.0	2.0
Chronic bronchitis/emphysema (mother)	1.5	1.8	7.0	-0.4	2.0	-1.3	0.1	-0.2	-0.4	-0.0	-1.1	0.2	2.6	0.7	-2.4	-1.4
Supplements: Vitamin C	1.5	1.7	3.8	-1.2	-1.1	0.7	1.8	1.7	1.9	1.0	0.6	1.5	0.4	1.6	1.3	1.0
Hypertension (Self-reported)	1.5	4.1	8.0	-1.9	-2.1	-2.5	-1.6	-1.7	-0.9	-2.2	-2.5	-1.6	-2.0	-2.8	-0.1	-2.5
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	4.7	-1.3	1.4	-1.7	-1.8	-2.0	-2.2	-1.9	-1.2	-1.1	0.3	-0.5	-1.8	-1.3
Illnesses of father: High blood pressure	1.5	1.9	4.6	0.4	-0.8	-1.7	-1.1	-1.2	-0.7	-1.3	-1.4	-0.9	-1.0	-2.1	-1.8	-2.1
Impedance of whole body	1.5	7.7	26.4	-0.5	5.1	-1.9	-2.7	-3.3	-4.7	-3.6	-0.3	-0.5	1.5	0.7	-3.8	-0.4
Sensitivity / hurt feelings	1.4	2.4	6.4	-2.0	2.0	-2.3	-0.3	-0.6	-0.7	-0.1	-2.5	0.8	0.6	-0.3	-1.8	-2.5
Pack years adult smoking proportion	1.4	2.1	4.9	-1.3	-1.0	0.6	1.7	1.6	1.8	2.1	0.3	2.2	1.5	1.8	-0.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.8	-2.0	-1.4	-1.7	-0.9	-0.9	-0.6	-1.1	-1.8	0.0	-1.4	-1.3	-1.4	-1.8
Allergy	1.4	3.2	12.8	-0.1	0.4	-1.3	-2.2	-2.4	-2.5	-3.6	-1.7	-1.6	0.3	-1.1	0.0	-1.7
Neuroticism score	1.4	2.9	9.0	-3.0	-1.0	-2.3	-1.0	-1.0	-1.1	-0.1	-2.7	0.0	-0.2	-1.0	-2.1	-2.6
Hair/balding pattern: Pattern 3	1.4	2.1	6.5	2.6	-1.1	1.7	0.3	0.7	0.9	2.0	1.8	1.0	-1.9	-0.6	0.5	1.7
Long-standing illness, disability or infirmity	1.4	2.1	5.1	-1.3	-0.9	-2.2	-0.7	-0.7	-0.2	1.2	-2.1	0.4	-1.2	-2.0	-1.6	-2.3
Friendships satisfaction	1.4	1.8	4.3	0.2	-1.7	-1.7	-0.6	-0.7	-0.1	-1.1	-2.1	-1.8	-1.1	-1.6	-0.3	-1.9
Cholesterol lowering medication	1.4	2.0	7.6	0.4	1.4	-1.7	-1.1	-1.0	-0.9	-0.8	-1.3	-1.3	-1.5	-2.8	-1.6	-1.3
Reaction Time	1.3	2.5	12.8	0.2	1.7	-2.0	-1.2	-1.6	-1.4	-3.6	-1.2	-1.6	-0.4	-0.6	-1.2	-1.3
BMI	1.3	7.3	16.5	0.4	-2.9	-2.7	-1.2	-1.1	0.3	-2.3	-4.0	-3.8	-2.9	-4.1	-0.5	-3.8
Medication: Co-codamol	1.3	1.5	3.6	-1.9	-0.8	-1.7	-1.2	-1.4	-1.4	-1.5	-1.5	-0.0	0.3	-0.4	-0.8	-1.4
High blood pressure	1.3	3.6	6.7	-2.2	-2.2	-2.4	-1.5	-1.6	-0.8	-1.8	-2.3	-1.6	-1.9	-2.6	-0.3	-2.3
Past tobacco smoking	1.3	2.5	5.2	2.3	-1.6	1.3	1.6	1.8	2.3	2.1	0.9	0.0	-1.3	0.6	1.7	1.2
Alcohol intake versus 10 years previously	1.3	1.9	4.2	-2.0	-1.6	0.6	1.8	1.9	2.1	1.5	0.6	1.7	0.8	0.3	0.7	0.7
Medication: Ventolin 100micrograms inhaler	1.3	1.7	10.8	-3.3	-1.1	-1.3	-0.9	-0.7	-0.5	0.1	-0.6	0.2	-1.7	-1.8	-0.4	-0.6
High blood pressure (siblings)	1.3	1.9	13.5	1.5	-3.7	-0.5	-0.8	-0.6	-0.1	1.0	-1.0	-1.1	-1.2	-1.0	0.3	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	6.2	-2.1	-0.4	-1.9	0.0	-0.0	0.6	-1.0	-2.5	-0.8	-0.9	-0.2	0.3	-2.2
Medication: Blood pressure	1.3	2.3	7.3	-0.4	-0.8	-1.7	-1.6	-1.6	-1.1	-1.7	-1.5	-1.2	-1.2	-2.7	-1.0	-2.0
Coronary Artery Disease (CAD)	1.2	1.5	4.5	0.7	-1.4	-0.5	0.7	0.8	1.5	-0.3	-1.6	-0.0	0.3	-2.1	-1.5	-1.9
Neuroticism (2016)	1.2	1.8	3.3	-1.8	-1.2	-1.8	-1.2	-1.2	-1.1	-0.6	-1.8	-0.3	-1.4	-1.3	-1.0	-1.6
Type 2 Diabetes (T2D) (2012)	1.2	1.3	4.3	0.6	-1.9	1.5	0.6	1.0	0.9	2.1	1.3	1.0	-0.0	0.5	0.1	1.3
Cardiovascular Disease	1.2	3.9	8.5	-0.6	-1.5	-2.6	-1.7	-1.8	-1.2	-2.9	-2.6	-2.3	-1.8	-1.8	-0.2	-2.5
Respiratory disease	1.2	2.8	8.7	-2.1	-2.7	1.3	1.4	1.7	1.8	2.9	1.1	1.5	-0.8	0.2	0.6	1.3
Diabetes (mother)	1.2	1.5	5.2	0.7	-2.3	0.2	0.9	0.9	1.6	0.0	-0.3	0.9	-1.9	-1.3	2.0	0.1
Average weekly fortified wine intake	1.2	1.4	3.6	1.5	0.1	1.6	1.2	1.2	1.1	0.8	1.1	0.8	-0.5	1.2	1.9	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	12.7	3.6	-2.6	0.3	-0.6	-0.3	0.1	0.3	-0.3	-1.3	-3.4	-1.6	0.6	0.0
Hair/balding pattern: Pattern 4	1.2	3.0	15.4	3.9	0.3	1.2	1.8	1.7	1.6	2.1	1.4	1.3	-1.1	1.2	0.6	1.4
Leg fat mass (right)	1.2	4.8	13.5	0.8	-3.0	-2.0	-0.6	-0.4	0.9	-0.7	-3.7	-1.7	-2.6	-3.3	-0.5	-3.4
Age at last live birth	1.2	1.7	3.9	1.4	-1.2	1.3	1.3	1.5	1.7	1.4	0.7	0.4	0.1	2.0	1.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.6	1.2	-0.6	-1.4	-0.3	-0.4	-0.2	-1.3	-1.5	-1.5	-0.3	0.1	-1.9	-1.7
Back pain experienced in last month	1.2	1.7	6.6	-1.0	2.4	0.9	1.0	0.7	0.6	0.9	0.5	2.6	1.8	1.3	0.2	0.5
Basal cell carcinoma (self-reported)	1.2	1.4	6.7	0.9	-0.5	-0.8	-1.3	-1.3	-1.4	-1.1	-0.4	1.1	-2.6	-1.0	-0.9	-0.6
Leg fat mass (left)	1.2	4.6	12.1	0.5	-3.5	-1.9	-0.5	-0.3	1.0	-0.4	-3.5	-1.5	-2.6	-3.2	-0.4	-3.2
Hearing difficulty/problems: Yes	1.1	1.6	6.1	0.2	1.1	-0.4	-1.9	-1.7	-2.5	1.2	0.8	0.8	-0.5	-1.2	-1.5	0.2
Trunk fat percentage	1.1	4.4	13.7	-0.5	-0.9	-2.6	-0.9	-0.9	0.1	-2.0	-3.7	-1.1	-2.0	-3.1	-1.8	-3.4
Maternal smoking around birth	1.1	1.5	8.4	-2.9	0.9	0.0	-0.0	-0.2	-0.8	-0.1	0.7	0.6	2.9	0.5	-0.9	0.4
Stomach or abdominal pain in last month	1.1	1.4	2.7	0.2	0.1	-1.2	-1.6	-1.6	-1.6	-1.2	-1.2	-0.4	-0.6	-1.6	-0.9	-1.2
Trunk fat mass	1.1	4.5	15.1	-0.3	-3.8	0.5	1.8	2.3	3.9	1.7	-1.7	1.7	-2.3	-1.6	1.4	-1.2
Financial difficulties in last 2 years	1.1	1.5	4.3	-2.1	-1.6	-1.6	0.3	0.2	0.5	-0.6	-2.1	-0.4	0.7	0.3	-0.6	-1.9
Fluid intelligence score	1.1	2.2	13.2	0.2	-3.6	-0.3	-1.4	-0.8	-0.5	0.8	-0.9	-0.9	-1.6	-1.5	-2.1	-1.0
Breastfed as a baby	1.1	1.4	7.5	-2.7	1.1	-1.2	-1.4	-1.3	-1.8	-0.2	-0.3	0.1	0.1	-0.3	-0.8	-0.5
Loud music exposure frequency	1.1	1.2	6.4	-2.5	1.1	-1.2	1.0	0.7	0.8	-0.0	-1.5	0.8	-0.1	0.4	0.5	-0.9
Comparative body size at age 10	1.1	2.9	10.6	0.1	-1.2	-2.1	-1.1	-1.4	-0.6	-1.5	-3.3	-0.9	-1.0	-2.1	-0.4	-3.0
Smoking status: Previous	1.1	1.6	3.9	-1.4	1.6	-0.9	-1.4	-1.6	-2.0	-1.8	-0.5	0.1	0.9	-0.7	-1.3	-0.9
Medication for cholesterol	1.1	1.7	4.4	1.0	0.3	1.7	1.1	1.0	1.1	0.8	1.3	1.5	0.8	2.1	1.8	1.3
Number of self-reported non-cancer illnesses	1.1	2.0	8.6	-2.9	-2.2	-1.7	-0.2	-0.4	0.2	0.4	-2.0	0.3	-0.9	-1.2	-0.3	-1.6
Miserableness	1.1	1.8	5.5	-2.2	-0.3	-1.7	-0.7	-0.8	-0.6	-1.4	-2.4	-1.5	-0.2	0.0	-0.9	-2.0
Financial situation satisfaction	1.1	1.4	6.6	-2.6	-0.0	-1.1	0.3	0.3	0.2	0.2	-1.2	0.7	0.8	-1.3	-1.9	-1.4
Medication: Atorvastatin	1.1	1.4	5.7	-0.6	0.8	-1.2	-1.0	-1.0	-0.7	-0.4	-1.1	-0.5	-0.8	-2.4	-1.7	-1.3
Irritability	1.1	1.9	4.7	-0.3	-0.2	-1.6	-1.7	-1.5	-2.1	-0.5	-1.6	-0.9	0.5	-0.4	-1.7	-2.2
Pack years of smoking	1.1	1.7	5.2	-0.9	-1.0	0.6	1.4	1.3	1.5	2.0	0.5	2.3	1.1	1.5	-0.3	0.8
Depressed Affect (Nagel 2018)	1.0	2.1	6.3	-1.2	-0.4	-2.0	-0.9	-1.0	-0.9	-0.4	-2.5	-0.8	-0.2	-0.8	-2.3	-2.4
Depression (Nagel 2018)	1.0	1.5	4.3	-1.5	-1.6	-1.6	-0.4	-0.4	0.0	-0.2	-2.1	-0.1	-1.3	-1.1	-1.0	-2.0
Neuroticism (Nagel 2018)	1.0	2.3	7.8	-1.6	-0.2	-2.1	-0.9	-0.9	-1.2	0.4	-2.2	0.5	-0.4	-0.8	-2.8	-2.5
LDL Cholesterol	1.0	1.6	13.8	1.5	3.7	-0.0	-0.5	-0.7	-1.0	-1.1	0.1	-0.9	0.8	0.3	-0.7	0.1
Neuroticism	1.0	2.4	6.4	-1.8	-1.4	-1.9	-1.1	-1.0	-1.0	0.3	-2.5	0.2	-0.8	-1.2	-2.1	-2.4
Relative age of first facial hair	1.0	2.1	7.6	-1.1	2.8	-0.7	-1.3	-1.5	-2.5	-0.7	0.3	-0.9	2.5	0.7	-1.0	-0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	4.1	-0.9	-0.4	-1.6	-0.8	-1.1	-1.0	-0.3	-1.6	-0.4	-0.3	-0.3	-2.0	-1.5
Had menopause	1.0	1.3	4.5	-0.8	-2.1	1.2	0.3	0.6	0.5	2.1	1.0	1.0	-0.6	-0.0	0.7	1.6
Qualifications: None of the above	1.0	2.0	4.3	-1.4	1.3	-1.7	-0.7	-1.1	-1.3	-2.1	-1.8	-2.0	1.3	-0.1	-1.2	-1.4
Father’s age at death	1.0	1.4	4.1	1.8	-0.4	1.6	-0.9	-0.7	-1.1	0.2	2.0	0.6	-0.2	0.3	1.6	1.6
Prospective memory result	1.0	1.2	5.8	-0.9	2.4	0.3	1.3	1.2	1.2	1.2	0.3	1.0	1.4	0.2	0.1	0.4
Pulse wave reflection index	1.0	1.3	4.7	2.2	-0.9	-0.0	-1.2	-0.8	-0.7	0.6	0.1	-0.4	-1.2	-1.9	-1.7	-0.5
Average weekly red wine intake	1.0	1.5	4.1	1.2	-0.1	0.9	1.2	1.5	1.9	1.5	-0.3	1.2	-1.0	0.7	2.0	-0.0
Commuting to job workplace: Public transport	1.0	1.2	4.6	-0.9	-0.4	1.3	-0.0	0.2	-0.2	1.6	2.1	0.6	0.1	0.0	0.7	2.1
Bipolar Disorder (2018)	0.9	1.4	9.1	2.1	-3.0	0.2	0.6	0.6	1.3	0.2	-0.4	-0.5	-1.0	-0.5	0.3	-0.1
Bipolar Disorder or Schizophrenia	0.9	2.2	8.8	2.0	-3.0	-0.1	1.0	1.0	1.7	1.4	-1.1	-0.6	-2.1	-0.8	1.4	-0.4
Heel T-Score	0.9	7.4	37.0	6.1	-3.3	-1.2	-0.9	-0.8	-0.5	2.2	-1.4	-2.1	-4.4	-3.2	-1.5	-1.1
Taking other prescription medications	0.9	1.3	6.0	-2.4	-0.6	-1.4	-0.8	-0.8	-0.5	0.3	-1.2	0.0	-0.8	-1.9	-0.7	-1.1
Chronic bronchitis/emphysema (father)	0.9	1.1	2.7	-1.5	1.1	-1.4	-0.7	-1.0	-0.7	-0.6	-1.6	-0.3	-0.5	-1.1	-0.5	-1.3
Impedance of arm (left)	0.9	4.1	23.2	-1.1	4.8	-0.3	-0.9	-1.4	-2.5	-2.6	0.8	1.6	1.8	1.7	-2.0	0.7
Arm fat mass (right)	0.9	3.9	12.6	-0.1	-3.5	-0.8	1.2	1.5	3.1	0.5	-2.7	0.0	-2.4	-2.3	0.8	-2.2
Exposure to tobacco smoke at home	0.9	1.0	4.5	-2.1	-0.4	-0.9	-1.3	-1.4	-1.6	-0.6	-0.3	0.0	0.0	-0.5	-0.7	-0.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	-1.0	0.8	-1.0	-1.2	-1.2	-1.4	-0.4	-0.7	0.8	0.1	-1.2	-1.5	-1.1
Worry too long after embarrassment	0.9	1.5	4.7	-0.9	-0.2	-1.7	-1.1	-1.1	-1.2	-0.3	-1.9	0.3	-0.7	-0.7	-1.5	-2.2
Eye problems/disorders: None of the above	0.9	1.1	2.1	0.3	0.8	1.3	1.4	1.5	1.3	0.1	1.1	0.8	0.8	1.3	0.3	1.2
Whole body fat mass	0.9	3.6	12.7	0.1	-3.6	-0.2	1.3	1.7	3.2	0.9	-2.3	0.6	-2.1	-2.0	0.9	-1.8
Arm fat mass (left)	0.9	3.5	12.7	-0.2	-3.6	-0.6	1.1	1.4	2.9	0.8	-2.6	0.2	-2.1	-2.3	0.5	-2.1
Pain experienced in last month	0.9	1.4	3.7	1.3	-1.1	1.2	1.6	1.8	1.9	1.1	0.6	0.1	-0.2	0.7	1.2	1.1
Schizophrenia vs Biploar Disorder	0.8	1.1	2.9	-0.8	1.4	0.3	1.4	1.1	0.8	1.4	-0.4	1.0	1.7	1.1	-0.1	-0.0
Alzheimer’s Disease (in mother)	0.8	0.9	1.9	0.7	0.4	-1.4	-1.0	-1.1	-1.2	-0.7	-1.1	0.4	-1.4	-0.8	-0.2	-1.2
Crohns Disease (2017)	0.8	1.8	5.2	0.3	0.5	1.6	1.5	1.7	1.6	0.1	1.7	-0.0	0.9	1.4	2.3	1.6
Body Mass Index (BMI) (2010)	0.8	1.1	5.5	1.0	-0.1	-0.6	-0.1	-0.1	0.6	-1.3	-0.9	-0.5	-1.6	-2.3	0.4	-1.2
HDL Cholesterol	0.8	1.4	6.8	0.2	2.6	-0.6	-0.6	-1.0	-1.5	-1.7	-0.0	-1.3	0.9	0.9	-1.0	-0.1
Serious illness, injury or assault to yourself	0.8	1.0	1.9	-1.0	-0.8	-1.2	-0.7	-0.8	-0.7	-1.0	-1.2	-0.6	-0.9	-1.4	-0.6	-1.2
Waist circumference	0.8	2.9	10.5	-1.9	-3.2	-1.3	-0.1	0.3	1.4	0.2	-2.5	-0.4	-1.7	-2.3	0.3	-2.2
Impedance of arm (right)	0.8	3.7	23.3	-0.9	4.8	-0.4	-0.4	-1.0	-2.0	-2.5	0.8	1.7	1.2	1.8	-1.5	0.8
Falls in the last year	0.8	1.1	2.2	-0.3	-0.4	-1.4	-1.1	-1.2	-1.2	-0.1	-1.2	-0.2	-0.9	-1.1	-1.4	-1.5
Tense / ‘highly strung’	0.8	1.4	6.0	-2.5	-1.0	-1.3	-0.2	-0.3	-0.4	-0.0	-1.5	0.9	-0.3	-0.5	-1.8	-1.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.7	-1.1	-2.4	-0.2	0.0	0.3	0.9	0.4	-0.5	0.1	-2.0	-1.0	1.9	-0.5
Glaucoma (self-reported)	0.8	1.0	2.5	1.6	-0.2	1.4	0.3	0.4	0.4	-0.0	0.8	-0.5	1.5	1.3	1.5	0.9
Number of children fathered	0.8	0.9	2.6	1.4	1.0	-0.3	-1.1	-1.0	-0.8	-1.0	-0.4	0.4	-1.3	-1.6	-0.4	-0.8
Mean time to correctly identify matches	0.8	1.6	9.2	1.3	1.5	-1.1	-0.9	-1.2	-1.1	-3.0	-0.6	-1.3	-0.8	-0.0	-0.4	-0.6
Leg pain on walking	0.8	1.0	5.0	-1.0	0.4	-0.4	-0.3	-0.4	-0.5	-0.2	-0.9	0.9	1.7	-0.8	-2.2	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	4.1	-0.7	0.6	-0.9	-0.9	-1.0	-1.3	-0.1	-0.3	0.3	0.4	-1.4	-2.0	-0.4
Ever had bowel cancer screening	0.8	0.9	1.9	-0.1	-1.1	-0.8	1.1	0.8	1.2	0.5	-1.4	1.0	0.1	0.3	1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	5.9	-2.4	2.1	-0.9	-0.8	-0.9	-1.5	-0.1	-0.8	0.6	1.4	0.6	-1.5	-0.7
Unable to work because of sickness or disability	0.8	1.1	2.5	-1.5	0.9	-1.6	0.4	0.2	0.3	-1.3	-1.5	-0.4	0.8	0.3	-1.1	-1.5
Heart disease (siblings)	0.8	1.0	3.6	-1.2	-1.2	-1.3	-0.3	-0.5	-0.1	-0.1	-1.9	0.7	-0.8	-0.2	0.9	-1.7
Breast Cancer	0.7	1.6	4.3	2.1	1.4	-1.1	-0.9	-1.0	-0.8	-1.7	-0.4	-1.7	-0.7	-1.1	-1.5	-0.7
Triglycerides	0.7	1.2	4.0	1.6	2.0	0.7	0.9	0.8	1.2	-0.7	0.5	-0.3	-0.4	-0.6	1.8	0.8
Medication for hormone replacement therapy	0.7	0.7	2.6	0.1	-0.3	0.6	1.2	0.9	0.7	0.3	0.7	0.2	1.4	1.6	0.4	1.0
Hearing difficulty/problems with background noise	0.7	1.0	5.0	0.1	0.5	0.5	-0.2	-0.2	-0.7	2.2	0.9	2.2	0.4	0.6	-0.9	0.8
Asthma	0.7	1.4	6.4	-2.5	-2.3	-0.1	-0.3	-0.1	0.0	1.2	0.4	0.3	-1.9	-1.0	-0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	3.8	-0.2	-1.4	-0.6	-0.1	-0.2	-0.1	2.0	-0.5	0.9	-1.9	0.0	-0.7	0.0
Pulse wave peak to peak time	0.7	0.8	2.0	-0.6	-0.3	0.8	1.0	0.9	0.9	0.3	0.4	1.0	1.0	1.3	1.4	0.7
Pulse rate, automated reading	0.7	2.3	17.3	-4.2	1.2	-0.3	-0.4	-0.8	-1.2	-1.5	0.9	0.6	1.7	1.2	-0.2	1.1
Alcohol intake frequency.	0.7	1.6	4.0	-1.6	-0.6	-2.0	-1.4	-1.4	-1.5	-1.1	-1.1	-0.1	-0.7	-1.2	-1.0	-1.3
Had major operations	0.7	0.8	1.9	-1.4	0.3	-0.5	-1.2	-1.2	-1.3	-1.1	-0.3	0.2	1.3	0.0	-1.0	-0.4
Mood swings	0.7	1.3	6.7	-2.6	-1.0	-1.5	-0.2	-0.3	-0.3	-0.3	-1.6	-0.4	0.6	0.2	-0.8	-1.6
Asthma (self-reported)	0.7	1.5	8.3	-2.9	-2.3	-0.2	-0.3	-0.1	0.1	1.1	0.1	0.2	-1.9	-0.8	-0.4	0.3
Ever taken oral contraceptive pill	0.7	0.8	1.6	0.9	0.9	-0.9	-1.0	-1.0	-1.3	-0.8	-0.5	-1.0	-1.2	0.6	-0.2	-0.7
Alzheimer’s Disease (in father)	0.6	0.6	3.1	0.6	0.3	-0.3	-0.8	-1.0	-1.0	-0.6	-0.4	0.3	0.2	-0.8	-1.8	-0.6
Smoking Status	0.6	1.5	4.0	-1.8	0.6	-0.8	-1.4	-1.6	-2.0	-1.9	-0.7	0.0	1.2	-0.3	-0.8	-0.7
Average weekly spirits intake	0.6	0.7	5.4	0.2	-0.2	-0.3	0.6	0.3	0.6	-0.5	-1.2	0.3	-0.5	-0.1	2.3	-0.9
Current tobacco smoking	0.6	1.0	4.8	-2.2	-0.2	-0.4	1.0	0.7	0.7	-0.7	-1.0	0.2	1.7	1.1	0.2	-0.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.8	0.2	1.0	1.1	0.4	0.5	0.4	0.1	1.3	1.4	-0.2	0.0	-0.5	1.0
Qualifications: CSEs or equivalent	0.6	0.7	4.2	-0.4	1.4	-0.2	0.5	0.1	-0.0	-2.1	-0.2	-0.8	0.5	0.8	1.3	0.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.5	0.9	0.9	0.3	1.5	1.6	1.7	1.9	1.0	0.5	-0.7	0.1	-0.4	0.7
Supplements: Glucosamine	0.6	0.7	2.7	1.6	-1.3	-0.1	0.2	0.2	0.4	1.4	-0.6	0.8	-1.1	-0.2	0.9	-0.4
Nervous feelings	0.6	1.1	3.3	-1.5	-0.2	-0.9	-0.2	-0.3	-0.9	1.2	-1.1	1.8	0.7	0.5	-1.5	-1.1
Worrier / anxious feelings	0.6	1.0	3.3	-1.8	-0.4	-0.2	-0.2	-0.1	-0.6	1.8	0.5	1.7	0.2	0.1	-1.7	0.4
Medication: Amlodipine	0.6	0.8	5.3	-2.3	0.1	-0.5	-0.6	-0.7	-0.6	-1.0	-0.0	-0.3	-0.8	-1.2	0.7	0.0
Neck or shoulder pain in last month	0.6	0.8	3.5	0.4	-1.4	-0.7	-0.6	-0.6	-0.2	1.1	-0.8	-0.0	-1.9	-1.0	0.3	-0.8
Migraine (self-reported)	0.6	0.8	5.7	-1.1	-2.4	0.1	-0.7	-0.5	-0.5	-0.4	0.2	-1.1	0.7	0.4	0.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.9	0.1	0.6	0.6	1.1	1.0	0.9	0.5	0.4	0.0	0.8	1.7	0.9	1.1
Handedness (chirality/laterality): Left-handed	0.6	0.8	4.7	-0.6	0.8	0.0	0.1	-0.0	-0.4	1.2	1.1	2.2	0.4	0.7	-0.3	0.9
Mother’s age at death	0.6	0.8	4.3	2.1	0.9	-0.4	-0.7	-0.8	-1.0	-0.2	0.1	0.5	-1.0	-0.1	-1.1	-0.2
Myopia	0.6	0.8	3.4	0.1	-0.6	1.3	-0.3	0.2	0.0	1.1	1.9	0.7	-0.3	-1.1	0.1	1.3
Intelligence (Savage-Jansen 2018)	0.5	1.5	9.1	0.1	-3.0	1.0	-1.1	-0.3	-0.3	1.9	0.4	-0.2	-1.2	-1.4	-0.8	0.3
Schizophrenia (2018)	0.5	1.1	2.5	0.8	-1.2	-0.4	0.8	0.8	1.2	1.5	-1.1	-0.4	-1.6	-0.7	1.4	-0.5
Worry (Nagel 2018)	0.5	1.1	6.1	-1.3	-0.1	-0.7	-0.3	-0.3	-0.7	1.4	-0.3	1.7	-0.6	-0.6	-2.5	-0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	8.4	1.0	-2.9	0.7	-0.4	0.0	0.2	2.0	-0.0	0.2	-0.8	-0.5	-0.8	-0.0
Ovarian Cancer	0.5	0.6	3.1	1.4	0.9	-0.2	0.4	0.2	0.3	-1.8	0.0	-0.5	-0.8	-0.4	1.0	-0.1
Schizophrenia (2014)	0.5	1.1	2.7	1.0	-1.5	-0.1	1.2	1.2	1.6	1.5	-0.8	-0.1	-1.0	-0.1	1.2	-0.2
Hypothyroidism (self reported)	0.5	1.1	5.2	-1.4	-2.3	0.8	0.7	0.8	1.2	1.6	0.1	0.7	-0.1	-0.2	0.4	0.6
Severe depression (siblings)	0.5	0.6	3.7	-0.2	-1.4	-0.1	0.3	0.4	0.5	1.9	-0.3	0.5	-0.7	0.2	-0.6	0.2
Medication: Atenolol	0.5	0.6	1.8	0.0	0.1	-0.9	0.9	1.0	1.3	-0.1	-1.0	-0.9	-0.1	-0.7	-0.2	-1.2
Medication: Levothyroxine sodium	0.5	0.8	4.1	-1.2	-2.0	-0.2	-0.6	-0.5	-0.0	0.8	-0.7	0.6	-0.9	-1.1	-0.4	-0.5
Number of incorrect matches in round	0.5	0.8	3.0	1.4	1.7	0.1	-0.8	-1.1	-1.1	-1.2	0.1	0.9	-0.2	-0.7	-0.5	0.0
Time employed in main current job	0.5	0.5	3.6	1.9	0.4	0.5	-0.1	-0.2	-0.2	-0.9	0.7	-0.1	-0.5	0.2	0.9	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.4	0.2	0.8	-0.9	-1.2	-1.1	-1.0	-1.1	-0.6	-0.1	-0.6	-0.7	-0.1	-1.0
Length of working week for main job	0.5	0.5	3.2	-0.2	-0.9	0.3	-0.3	0.0	0.2	0.1	0.4	-0.3	-1.0	-1.8	-1.0	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	7.4	-1.4	-2.7	-0.1	-0.1	-0.0	0.5	0.8	-0.9	0.5	-0.4	-0.7	0.5	-0.4
Wheeze or whistling in the chest in last year	0.5	0.9	4.0	-2.0	-1.3	-0.9	-0.3	-0.1	-0.0	1.1	0.2	-0.1	-1.0	-1.1	-1.4	-0.1
Medication: Seretide 50 evohaler	0.5	0.6	1.6	-1.3	-0.9	0.0	-0.6	-0.5	-0.7	0.3	1.0	-0.3	-0.6	-0.6	-1.1	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.8	-1.0	1.3	-0.4	0.1	-0.1	0.0	-1.7	-0.1	1.0	0.3	-0.2	0.4	-0.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.4	1.6	0.7	-0.5	-0.6	-0.6	-0.4	0.4	-0.8	-0.8	-1.0	-1.0	-0.0	-0.5
Eye problems/disorders: Cataract	0.5	0.6	3.1	0.4	-1.4	-0.5	-0.5	-0.4	-0.1	0.8	-0.5	-0.5	-0.8	-1.8	-0.5	-0.7
Smoking status: Current	0.5	0.8	5.4	-2.3	-0.0	-0.5	0.4	0.1	0.0	-0.6	-0.8	0.2	1.4	1.0	-0.3	-0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.6	1.0	1.0	0.3	-0.7	-0.7	-0.8	-1.2	0.3	-1.3	0.8	0.1	0.9	0.2
Medication: Bendroflumethiazide	0.5	0.7	3.0	-1.6	-0.9	-0.5	-0.8	-0.7	-0.6	-0.4	-0.0	-0.7	-0.6	-1.7	-0.5	-0.1
Alcohol drinker status: Never	0.5	0.6	2.7	-1.4	1.7	-0.5	-0.8	-0.8	-0.9	-0.6	0.2	-0.0	-0.1	0.2	0.5	0.1
Diastolic blood pressure, automated reading	0.5	1.7	5.8	-1.8	-2.4	-1.1	-0.4	-0.5	-0.0	-1.6	-1.6	-1.1	-1.1	-0.9	1.1	-1.0
HbA1C	0.4	0.4	1.4	-0.3	0.5	-0.3	-0.8	-0.8	-1.0	-1.2	0.3	-1.1	0.0	-0.5	0.0	0.2
Blood Red Count	0.4	3.8	15.1	3.9	0.9	-0.6	-2.0	-2.0	-2.5	-1.1	0.9	0.6	-2.2	-2.2	-2.5	0.4
Allergy or Eczema	0.4	1.0	4.7	0.8	0.4	0.5	0.7	0.9	0.8	2.2	1.3	0.6	-0.9	-0.4	-1.0	1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	3.2	-1.8	-0.1	-0.7	-0.6	-0.4	-0.4	0.0	-0.7	-0.1	-0.5	-0.0	-0.2	-0.8
High blood pressure (mother)	0.4	0.5	2.0	1.3	-1.4	0.5	-0.2	0.0	0.4	0.3	0.3	-0.2	-0.6	-1.3	0.5	0.3
Alcohol usually taken with meals	0.4	0.6	2.7	0.7	-1.6	-0.2	0.0	0.3	0.7	0.1	-0.7	-0.6	-1.0	0.1	1.2	-0.7
Had other major operations	0.4	0.5	1.7	-1.0	0.7	-1.1	0.2	0.1	0.3	-0.2	-0.6	0.0	-0.3	-1.3	-0.8	-0.8
Medication: Ibuprofen	0.4	0.5	1.2	0.1	-0.0	-0.7	-1.1	-1.0	-0.9	-0.8	-0.3	0.0	-0.9	-0.6	0.7	-0.7
Suffer from ‘nerves’	0.4	0.6	2.4	-1.5	-1.3	-0.9	-0.3	-0.3	-0.4	0.3	-1.0	0.2	-0.6	-0.6	-0.9	-0.7
Qualifications: nursing, teaching	0.4	0.6	2.3	0.4	-1.5	-0.8	-0.3	-0.2	0.1	0.3	-0.8	-0.9	-1.4	-0.7	0.2	-0.8
Wears glasses or contact lenses	0.4	0.5	1.1	0.9	1.1	0.7	-0.3	-0.0	-0.6	0.9	1.0	0.9	0.4	-0.3	-0.2	0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.9	0.5	-0.7	-0.7	-0.6	-0.7	-0.7	0.5	-0.4	-0.3	-1.7	-0.2	0.5	-0.4
Ever smoked	0.4	0.7	4.1	-2.0	0.4	-0.4	0.2	0.1	-0.2	-0.5	-0.6	0.6	1.7	1.0	-0.1	-0.6
Average weekly beer plus cider intake	0.4	0.6	1.4	-1.2	0.7	-0.5	-0.8	-0.9	-1.1	-0.7	-0.3	-0.8	0.6	0.2	-1.0	-0.2
Supplements: Calcium	0.4	0.5	2.1	-1.5	0.1	-0.7	0.5	0.4	0.8	-0.3	-0.8	0.1	-0.6	-0.2	0.9	-0.9
Alzheimer’s Disease (including proxy)	0.3	0.5	1.1	0.3	0.4	-0.8	-0.6	-1.0	-1.0	-0.6	-0.5	0.9	-0.3	-0.2	-0.9	-0.7
Mean Putamen Volume	0.3	0.4	1.0	0.6	0.3	0.6	0.4	0.5	0.7	0.2	1.0	0.2	-1.0	-0.0	-0.3	1.0
Fasting Glucose	0.3	0.4	1.1	1.0	-0.4	0.7	0.3	0.3	0.1	1.1	0.8	0.4	-0.8	-0.3	-0.1	0.8
Primary Biliary Cirrhosis	0.3	0.5	2.8	-1.7	-0.5	-0.2	0.7	0.5	0.9	0.3	-0.5	0.6	-0.1	0.3	1.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	2.5	0.0	-1.6	0.0	0.6	0.5	0.5	0.7	-0.4	0.5	-0.1	0.3	-0.1	0.1
Diabetes (father)	0.3	0.4	2.6	0.6	-0.5	0.1	-0.1	0.0	0.5	-0.6	-0.4	-1.0	0.1	-1.6	0.1	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	2.6	-1.6	-0.5	-0.5	0.3	0.2	0.3	-0.1	-0.4	-0.6	-0.4	-0.0	-0.1	0.0
Pain all over the body in last month	0.3	0.3	1.1	-1.1	0.1	-0.7	0.8	0.6	0.8	0.0	-0.7	0.6	0.1	0.3	0.1	-0.4
Diabetes (self-reported)	0.3	0.5	3.0	-0.9	-1.7	0.1	-0.2	0.1	0.5	0.4	-0.3	-0.3	-0.6	-1.0	-0.1	-0.3
Number of live births	0.3	0.4	1.4	0.3	-0.4	0.5	0.4	0.2	0.2	-0.8	0.5	-0.4	0.5	0.9	1.2	0.8
Noisy workplace	0.3	0.4	1.8	-0.8	0.6	-0.7	-0.1	-0.3	-0.4	-0.6	-0.6	1.4	-0.0	-0.9	0.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	2.1	0.5	-0.4	0.4	-0.2	-0.1	-0.2	-0.5	0.7	0.4	0.1	-0.6	-1.5	0.3
Mouth/teeth dental problems: Dentures	0.3	0.6	1.6	-0.2	0.8	0.6	1.1	1.0	1.3	0.4	0.6	0.9	0.9	0.3	0.1	0.6
Pulse wave Arterial Stiffness index	0.3	0.3	1.8	0.7	-0.4	0.0	-0.3	-0.1	0.2	0.7	0.0	-0.1	-1.3	-1.0	-0.6	-0.2
Birth weight of first child	0.3	0.6	2.7	-1.3	1.6	-0.2	0.3	0.2	0.2	-0.6	-0.4	1.5	0.6	0.3	-0.0	-0.1
Headache pain in last month	0.3	0.5	2.6	-0.9	-0.3	0.6	-0.1	0.1	-0.1	0.9	0.5	0.3	1.6	-0.0	-1.3	0.0
Age at first live birth	0.3	0.6	3.6	1.9	-0.4	0.5	0.3	0.5	0.5	1.0	0.4	0.2	-0.9	0.7	0.7	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.6	1.6	-0.6	-0.0	0.4	0.3	0.7	0.1	-0.9	-0.1	-0.5	0.3	0.1	-0.6
Emphysema/chronic bronchitis	0.3	0.3	0.6	-0.6	0.6	-0.4	0.7	0.5	0.4	0.5	-0.2	0.8	0.6	0.6	0.6	-0.3
Family relationship satisfaction	0.3	0.4	1.0	0.6	-1.0	-0.7	-0.2	-0.0	0.3	-0.1	-0.8	-0.6	-0.7	-0.7	-0.3	-1.0
Diabetes diagnosed by doctor	0.3	0.4	2.1	-1.0	-1.5	-0.3	-0.4	-0.1	0.2	0.5	-0.5	-0.3	0.0	-1.0	-0.6	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.3	0.0	-0.0	-0.3	-0.4	-0.5	-0.3	-0.3	-0.9	0.4	-0.1	-0.8	-1.2	-1.0
Mineral and other dietary supplements	0.3	0.4	1.6	0.4	0.0	0.9	0.1	0.3	0.2	-0.5	0.9	0.1	1.3	-0.2	-0.9	0.7
Breast cancer (self-reported)	0.3	0.4	1.7	-1.3	-0.5	-0.8	-0.3	-0.2	-0.2	-0.4	-0.9	-0.2	-0.4	-0.5	0.1	-1.0
Average weekly champagne plus white wine intake	0.3	0.4	2.0	0.6	-1.4	0.3	-0.4	-0.3	-0.1	0.6	0.4	0.8	-0.6	-0.4	-0.9	-0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.2	-0.1	1.1	0.6	0.5	0.5	0.4	-0.7	0.5	-0.2	0.6	1.0	0.5	0.5
Blood Eosinophil Count	0.2	1.6	5.2	-1.4	-1.0	-1.4	-1.0	-0.9	-0.5	-1.2	-0.8	-2.3	-1.5	-1.6	-0.2	-1.1
Blood Platelet Count	0.2	2.6	11.4	-0.1	-3.2	0.5	-0.4	-0.0	-0.7	3.4	1.4	0.4	0.7	-0.2	-2.7	1.0
Blood White Count	0.2	1.5	3.9	1.1	-1.8	-1.3	-0.3	-0.5	0.2	-0.4	-1.6	0.3	-2.0	-1.9	-0.1	-1.5
Ever had hysterectomy (womb removed)	0.2	0.3	0.9	-0.8	0.4	-0.6	-0.0	-0.2	-0.2	-0.9	0.1	-0.4	-0.3	-0.1	1.0	0.3
Medication: Metformin	0.2	0.3	1.8	-0.2	-1.3	0.2	0.0	0.2	0.6	0.1	-0.4	-0.3	-0.0	-0.7	0.6	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.2	-1.1	-0.4	-0.3	0.3	0.3	0.5	-0.3	-0.6	0.2	0.1	0.6	0.0	-0.5
Medication: Allopurinol	0.2	0.2	0.6	-0.2	0.5	-0.5	-0.3	-0.4	-0.3	-0.1	-0.7	0.0	-0.7	-0.6	-0.3	-0.8
Osteoporosis (self-reported)	0.2	0.3	1.3	-0.9	-0.1	0.7	-0.0	-0.2	-0.3	-0.5	0.2	0.5	1.2	0.4	-0.5	0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.7	-0.8	0.0	-0.6	-0.4	-0.4	0.7	0.0	0.5	-0.7	0.0	0.5	-0.2
Ever depressed for a whole week	0.2	0.2	0.5	-0.6	0.6	-0.7	-0.1	-0.2	-0.1	-0.3	-0.7	0.2	-0.7	0.2	-0.6	-0.6
Alcohol drinker status: Previous	0.2	0.3	0.9	0.0	-0.6	0.2	0.0	0.1	0.1	1.0	0.7	0.4	-0.5	-0.7	0.1	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.0	0.1	-1.0	0.1	-0.2	0.1	0.2	0.3	0.0	-0.9	-0.3	-0.8	-0.3	0.0
Gout (self-reported)	0.1	0.1	0.4	-0.3	0.4	0.5	-0.1	-0.0	-0.1	0.3	0.1	0.4	-0.4	-0.6	0.2	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.9	0.0	0.1	-0.0	-0.3	-0.2	-0.3	0.8	0.2	0.9	-0.2	-0.4	-0.5	0.0

Hub : Genes

EIF6

Models

Trait associations