Hub : Genes

EIF6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Caudate basal ganglia 0.3230 0.0990 1.3e-03 0.021 NA 0.070 NA 0.081 8.0e-02 NA 4.8e-03 NA 2.5e-03
2 GTEx Brain Hippocampus 0.4048 0.1350 1.2e-03 -0.004 NA -0.012 NA 0.052 4.2e-01 NA 7.8e-01 NA 2.4e-02
3 GTEx Lung 0.1967 0.0650 2.2e-05 0.102 NA 0.081 NA 0.087 3.2e-08 NA 9.1e-07 NA 3.4e-07
4 GTEx Muscle Skeletal 0.3177 0.0531 0.0e+00 0.251 NA 0.249 NA 0.266 1.6e-24 NA 2.8e-24 NA 4.6e-26
5 GTEx Skin Not Sun Exposed Suprapubic 0.3240 0.0850 1.6e-05 0.113 NA 0.035 NA 0.070 9.0e-07 NA 5.1e-03 NA 1.1e-04
6 GTEx Skin Sun Exposed Lower leg 0.4000 0.0770 2.5e-13 0.210 NA 0.158 NA 0.190 3.0e-17 NA 4.4e-13 NA 1.2e-15
7 METSIM Adipose 0.0719 0.0293 1.0e-06 0.022 0.043 0.032 0.044 0.040 2.6e-04 4.2e-07 1.2e-05 2.7e-07 9.1e-07
8 NTR Blood 0.0698 0.0243 2.3e-12 0.053 0.042 0.049 0.047 0.051 1.4e-16 2.0e-13 1.5e-15 6.7e-15 4.1e-16
9 YFS Blood 0.0194 0.0087 5.3e-05 0.004 0.012 0.008 0.012 0.006 1.6e-02 4.1e-05 7.6e-04 4.3e-05 2.7e-03
10 TCGA Glioblastoma Multiforme 0.1590 0.0880 9.5e-03 0.038 0.056 0.009 NA 0.043 2.6e-02 8.6e-03 1.7e-01 NA 1.9e-02
11 TCGA Head and Neck Squamous Cell Carcinoma 0.0340 0.0202 3.3e-03 0.025 0.026 0.030 NA 0.018 6.8e-04 5.4e-04 2.4e-04 NA 3.6e-03
12 TCGA Brain Lower Grade Glioma 0.2028 0.0985 1.2e-06 0.014 0.030 0.043 NA 0.036 9.7e-03 2.3e-04 1.1e-05 NA 5.2e-05
13 TCGA Pancreatic Adenocarcinoma 0.3070 0.1110 1.4e-04 0.109 0.074 0.038 NA 0.081 2.5e-05 5.0e-04 1.0e-02 NA 2.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bipolar Disorder (2018) 0.9 1.4 9.1 2.1 -3.0 0.2 0.6 0.6 1.3 0.2 -0.4 -0.5 -1.0 -0.5 0.3 -0.1
Bipolar Disorder or Schizophrenia 0.9 2.2 8.8 2.0 -3.0 -0.1 1.0 1.0 1.7 1.4 -1.1 -0.6 -2.1 -0.8 1.4 -0.4
Depressed Affect (Nagel 2018) 1.0 2.1 6.3 -1.2 -0.4 -2.0 -0.9 -1.0 -0.9 -0.4 -2.5 -0.8 -0.2 -0.8 -2.3 -2.4
Depression (Nagel 2018) 1.0 1.5 4.3 -1.5 -1.6 -1.6 -0.4 -0.4 0.0 -0.2 -2.1 -0.1 -1.3 -1.1 -1.0 -2.0
Intelligence (Savage-Jansen 2018) 0.5 1.5 9.1 0.1 -3.0 1.0 -1.1 -0.3 -0.3 1.9 0.4 -0.2 -1.2 -1.4 -0.8 0.3
Neuroticism (Nagel 2018) 1.0 2.3 7.8 -1.6 -0.2 -2.1 -0.9 -0.9 -1.2 0.4 -2.2 0.5 -0.4 -0.8 -2.8 -2.5
Schizophrenia (2018) 0.5 1.1 2.5 0.8 -1.2 -0.4 0.8 0.8 1.2 1.5 -1.1 -0.4 -1.6 -0.7 1.4 -0.5
Schizophrenia vs Biploar Disorder 0.8 1.1 2.9 -0.8 1.4 0.3 1.4 1.1 0.8 1.4 -0.4 1.0 1.7 1.1 -0.1 -0.0
Worry (Nagel 2018) 0.5 1.1 6.1 -1.3 -0.1 -0.7 -0.3 -0.3 -0.7 1.4 -0.3 1.7 -0.6 -0.6 -2.5 -0.4
Alzheimer’s Disease (in mother) 0.8 0.9 1.9 0.7 0.4 -1.4 -1.0 -1.1 -1.2 -0.7 -1.1 0.4 -1.4 -0.8 -0.2 -1.2
Alzheimer’s Disease (in father) 0.6 0.6 3.1 0.6 0.3 -0.3 -0.8 -1.0 -1.0 -0.6 -0.4 0.3 0.2 -0.8 -1.8 -0.6
Alzheimer’s Disease (including proxy) 0.3 0.5 1.1 0.3 0.4 -0.8 -0.6 -1.0 -1.0 -0.6 -0.5 0.9 -0.3 -0.2 -0.9 -0.7
Crohns Disease (2017) 0.8 1.8 5.2 0.3 0.5 1.6 1.5 1.7 1.6 0.1 1.7 -0.0 0.9 1.4 2.3 1.6
Irritable Bowel Disease (IBD) 3.5 8.3 14.1 -0.1 -1.5 3.2 3.5 3.8 3.6 3.3 2.9 1.8 1.2 3.0 3.4 3.3
Ulcerative Colitis (UC) 5.9 11.1 24.8 0.1 -2.4 3.6 4.2 4.4 4.2 5.0 2.9 2.5 1.2 3.3 2.7 3.6
Major Depression (MDD) 2.1 2.5 6.1 -1.3 -0.4 -2.5 -1.3 -1.4 -1.1 -0.5 -2.4 -1.8 -1.2 -1.4 -1.5 -2.2
Reaction Time 1.3 2.5 12.8 0.2 1.7 -2.0 -1.2 -1.6 -1.4 -3.6 -1.2 -1.6 -0.4 -0.6 -1.2 -1.3
Verbal and Numeric Reasoning (VNR) 0.5 1.2 8.4 1.0 -2.9 0.7 -0.4 0.0 0.2 2.0 -0.0 0.2 -0.8 -0.5 -0.8 -0.0
Breast Cancer 0.7 1.6 4.3 2.1 1.4 -1.1 -0.9 -1.0 -0.8 -1.7 -0.4 -1.7 -0.7 -1.1 -1.5 -0.7
Ovarian Cancer 0.5 0.6 3.1 1.4 0.9 -0.2 0.4 0.2 0.3 -1.8 0.0 -0.5 -0.8 -0.4 1.0 -0.1
Prostate Cancer 1.5 2.0 5.5 -1.6 1.9 -1.1 -1.7 -1.7 -2.3 -0.8 -0.7 -0.8 1.7 0.1 -1.7 -0.8
Age at First Birth 1.8 2.6 9.1 1.4 -0.1 1.8 1.6 1.8 1.5 3.0 1.7 1.8 -0.1 1.3 0.5 2.0
Bipolar Disorder (2011) 1.6 1.6 8.5 2.9 -0.5 1.3 1.2 1.2 1.6 1.1 1.3 -0.4 -0.4 -0.0 0.8 0.0
Body Mass Index (BMI) (2010) 0.8 1.1 5.5 1.0 -0.1 -0.6 -0.1 -0.1 0.6 -1.3 -0.9 -0.5 -1.6 -2.3 0.4 -1.2
Coronary Artery Disease (CAD) 1.2 1.5 4.5 0.7 -1.4 -0.5 0.7 0.8 1.5 -0.3 -1.6 -0.0 0.3 -2.1 -1.5 -1.9
Crohns Disease (2012) 1.7 2.7 5.8 0.7 -0.8 2.1 1.6 1.8 1.5 0.6 2.1 0.7 0.9 2.2 2.4 2.2
Mean Putamen Volume 0.3 0.4 1.0 0.6 0.3 0.6 0.4 0.5 0.7 0.2 1.0 0.2 -1.0 -0.0 -0.3 1.0
Fasting Glucose 0.3 0.4 1.1 1.0 -0.4 0.7 0.3 0.3 0.1 1.1 0.8 0.4 -0.8 -0.3 -0.1 0.8
HbA1C 0.4 0.4 1.4 -0.3 0.5 -0.3 -0.8 -0.8 -1.0 -1.2 0.3 -1.1 0.0 -0.5 0.0 0.2
HDL Cholesterol 0.8 1.4 6.8 0.2 2.6 -0.6 -0.6 -1.0 -1.5 -1.7 -0.0 -1.3 0.9 0.9 -1.0 -0.1
LDL Cholesterol 1.0 1.6 13.8 1.5 3.7 -0.0 -0.5 -0.7 -1.0 -1.1 0.1 -0.9 0.8 0.3 -0.7 0.1
Lupus 3.0 4.5 8.7 1.6 1.2 3.0 2.1 2.3 2.0 2.2 2.6 2.3 1.6 2.4 1.1 2.4
Neuroticism (2016) 1.2 1.8 3.3 -1.8 -1.2 -1.8 -1.2 -1.2 -1.1 -0.6 -1.8 -0.3 -1.4 -1.3 -1.0 -1.6
Primary Biliary Cirrhosis 0.3 0.5 2.8 -1.7 -0.5 -0.2 0.7 0.5 0.9 0.3 -0.5 0.6 -0.1 0.3 1.0 -0.1
Rheumatoid Arthritis 1.6 2.1 11.2 -3.3 2.1 0.8 0.6 0.8 0.3 0.4 1.4 1.1 2.3 1.1 0.3 1.0
Schizophrenia (2014) 0.5 1.1 2.7 1.0 -1.5 -0.1 1.2 1.2 1.6 1.5 -0.8 -0.1 -1.0 -0.1 1.2 -0.2
Triglycerides 0.7 1.2 4.0 1.6 2.0 0.7 0.9 0.8 1.2 -0.7 0.5 -0.3 -0.4 -0.6 1.8 0.8
Type 2 Diabetes (T2D) (2012) 1.2 1.3 4.3 0.6 -1.9 1.5 0.6 1.0 0.9 2.1 1.3 1.0 -0.0 0.5 0.1 1.3
Ulcerative Colitis 6.7 9.7 18.5 -0.7 -2.9 3.5 3.7 3.9 3.8 4.3 2.7 2.3 1.1 2.8 3.0 3.5
Blood Eosinophil Count 0.2 1.6 5.2 -1.4 -1.0 -1.4 -1.0 -0.9 -0.5 -1.2 -0.8 -2.3 -1.5 -1.6 -0.2 -1.1
Blood Platelet Count 0.2 2.6 11.4 -0.1 -3.2 0.5 -0.4 -0.0 -0.7 3.4 1.4 0.4 0.7 -0.2 -2.7 1.0
Blood Red Count 0.4 3.8 15.1 3.9 0.9 -0.6 -2.0 -2.0 -2.5 -1.1 0.9 0.6 -2.2 -2.2 -2.5 0.4
Blood White Count 0.2 1.5 3.9 1.1 -1.8 -1.3 -0.3 -0.5 0.2 -0.4 -1.6 0.3 -2.0 -1.9 -0.1 -1.5
Heel T-Score 0.9 7.4 37.0 6.1 -3.3 -1.2 -0.9 -0.8 -0.5 2.2 -1.4 -2.1 -4.4 -3.2 -1.5 -1.1
BMI 1.3 7.3 16.5 0.4 -2.9 -2.7 -1.2 -1.1 0.3 -2.3 -4.0 -3.8 -2.9 -4.1 -0.5 -3.8
Height 19.6 377.3 800.9 -1.6 -16.6 22.4 20.9 24.4 28.3 25.6 14.3 23.8 -1.7 11.6 21.2 16.7
Waist Hip Ratio (WHR) 2.1 9.3 22.3 -4.4 3.9 -2.9 -2.9 -3.4 -4.7 -2.7 -0.6 -1.8 3.3 -0.1 -3.7 -1.1
Systolic Blood Pressure 1.6 7.9 20.1 1.4 -3.8 3.0 2.9 3.2 3.7 2.0 2.4 1.5 -1.4 1.7 4.5 2.9
Smoking Status 0.6 1.5 4.0 -1.8 0.6 -0.8 -1.4 -1.6 -2.0 -1.9 -0.7 0.0 1.2 -0.3 -0.8 -0.7
Allergy or Eczema 0.4 1.0 4.7 0.8 0.4 0.5 0.7 0.9 0.8 2.2 1.3 0.6 -0.9 -0.4 -1.0 1.1
Cardiovascular Disease 1.2 3.9 8.5 -0.6 -1.5 -2.6 -1.7 -1.8 -1.2 -2.9 -2.6 -2.3 -1.8 -1.8 -0.2 -2.5
Hypothyroidism (self reported) 0.5 1.1 5.2 -1.4 -2.3 0.8 0.7 0.8 1.2 1.6 0.1 0.7 -0.1 -0.2 0.4 0.6
Respiratory disease 1.2 2.8 8.7 -2.1 -2.7 1.3 1.4 1.7 1.8 2.9 1.1 1.5 -0.8 0.2 0.6 1.3
Type 2 Diabetes (T2D) (2018) 0.1 0.2 1.0 0.1 -1.0 0.1 -0.2 0.1 0.2 0.3 0.0 -0.9 -0.3 -0.8 -0.3 0.0
Lung FEV1/FVC ratio 2.9 14.5 40.4 0.8 -2.2 5.0 3.6 4.1 4.1 6.4 3.6 5.0 2.5 3.0 1.9 3.9
Lung FVC 4.1 20.8 46.6 -5.5 5.6 -5.7 -4.5 -5.6 -6.8 -5.1 -3.6 -2.4 1.3 -0.7 -3.9 -3.9
Neuroticism 1.0 2.4 6.4 -1.8 -1.4 -1.9 -1.1 -1.0 -1.0 0.3 -2.5 0.2 -0.8 -1.2 -2.1 -2.4
Chronotype (morning person) 2.0 4.7 9.7 -1.3 -0.7 1.9 2.4 2.5 2.3 3.0 2.4 3.1 0.7 1.9 1.6 2.5
Hair Pigment 5.9 167.0 558.6 -9.6 11.3 -14.0 -15.3 -16.9 -23.6 -13.3 -8.6 9.4 -4.8 -4.7 -13.4 -10.6
Tanning 15.2 185.2 552.2 8.2 -10.8 15.2 16.4 17.9 23.5 14.8 11.1 -6.3 5.7 8.2 14.1 13.1
Hand grip strength (left) 11.9 31.3 64.0 3.0 -3.5 6.7 6.4 7.1 8.0 6.3 4.5 6.0 -0.4 3.8 6.9 5.2
Number of treatments/medications taken 2.2 4.0 11.0 -3.3 -1.4 -2.7 -1.5 -1.5 -0.9 -0.3 -2.4 -0.1 -1.9 -3.2 -0.9 -2.3
Average weekly spirits intake 0.6 0.7 5.4 0.2 -0.2 -0.3 0.6 0.3 0.6 -0.5 -1.2 0.3 -0.5 -0.1 2.3 -0.9
Sensitivity / hurt feelings 1.4 2.4 6.4 -2.0 2.0 -2.3 -0.3 -0.6 -0.7 -0.1 -2.5 0.8 0.6 -0.3 -1.8 -2.5
Frequency of depressed mood in last 2 weeks 1.9 2.6 7.7 -2.1 -1.0 -2.4 -0.9 -1.0 -0.6 -1.3 -2.7 -0.7 -0.6 -1.0 -1.5 -2.8
Hearing difficulty/problems: Yes 1.1 1.6 6.1 0.2 1.1 -0.4 -1.9 -1.7 -2.5 1.2 0.8 0.8 -0.5 -1.2 -1.5 0.2
Relative age of first facial hair 1.0 2.1 7.6 -1.1 2.8 -0.7 -1.3 -1.5 -2.5 -0.7 0.3 -0.9 2.5 0.7 -1.0 -0.1
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 10.7 -3.3 -0.4 -1.7 -0.7 -1.0 -1.0 0.7 -2.1 1.2 0.6 -0.4 -0.7 -1.8
Ever used hormone-replacement therapy (HRT) 0.3 0.3 2.5 0.0 -1.6 0.0 0.6 0.5 0.5 0.7 -0.4 0.5 -0.1 0.3 -0.1 0.1
Ever had hysterectomy (womb removed) 0.2 0.3 0.9 -0.8 0.4 -0.6 -0.0 -0.2 -0.2 -0.9 0.1 -0.4 -0.3 -0.1 1.0 0.3
Systolic blood pressure, automated reading 1.7 5.0 8.8 2.6 -3.0 2.3 2.1 2.4 2.7 2.3 1.6 1.5 -1.5 0.6 2.9 2.2
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 3.2 -1.8 -0.1 -0.7 -0.6 -0.4 -0.4 0.0 -0.7 -0.1 -0.5 -0.0 -0.2 -0.8
Angina 2.1 2.8 8.4 0.1 -0.7 -2.3 -0.7 -0.7 -0.1 -0.8 -2.4 -1.1 -1.5 -2.9 -2.0 -2.7
Medication for hormone replacement therapy 0.7 0.7 2.6 0.1 -0.3 0.6 1.2 0.9 0.7 0.3 0.7 0.2 1.4 1.6 0.4 1.0
Vitamin and mineral supplements 3.1 4.2 9.7 0.4 1.3 -1.5 -3.0 -2.9 -3.0 -3.1 -1.3 -2.1 -1.0 -2.0 -1.1 -1.7
Supplements: Zinc 2.3 2.5 6.6 0.0 -1.5 1.1 1.9 2.1 2.6 1.5 1.4 -0.0 -1.2 0.7 2.3 1.6
Medication: Co-codamol 1.3 1.5 3.6 -1.9 -0.8 -1.7 -1.2 -1.4 -1.4 -1.5 -1.5 -0.0 0.3 -0.4 -0.8 -1.4
Medication: Metformin 0.2 0.3 1.8 -0.2 -1.3 0.2 0.0 0.2 0.6 0.1 -0.4 -0.3 -0.0 -0.7 0.6 -0.4
Diabetes (father) 0.3 0.4 2.6 0.6 -0.5 0.1 -0.1 0.0 0.5 -0.6 -0.4 -1.0 0.1 -1.6 0.1 -0.3
Diabetes (mother) 1.2 1.5 5.2 0.7 -2.3 0.2 0.9 0.9 1.6 0.0 -0.3 0.9 -1.9 -1.3 2.0 0.1
Severe depression (siblings) 0.5 0.6 3.7 -0.2 -1.4 -0.1 0.3 0.4 0.5 1.9 -0.3 0.5 -0.7 0.2 -0.6 0.2
Pack years adult smoking proportion 1.4 2.1 4.9 -1.3 -1.0 0.6 1.7 1.6 1.8 2.1 0.3 2.2 1.5 1.8 -0.2 0.7
Impedance of leg (right) 2.8 13.7 40.4 0.9 4.5 -3.5 -4.3 -5.0 -6.4 -4.1 -1.7 -3.2 1.1 -0.5 -5.1 -2.0
Leg fat-free mass (left) 12.0 63.5 174.2 0.1 -8.5 8.3 9.2 10.7 13.2 9.7 4.2 8.2 -2.1 2.9 9.6 5.2
Trunk fat percentage 1.1 4.4 13.7 -0.5 -0.9 -2.6 -0.9 -0.9 0.1 -2.0 -3.7 -1.1 -2.0 -3.1 -1.8 -3.4
Hand grip strength (right) 14.0 38.1 79.0 2.3 -4.7 7.5 6.9 7.9 8.9 7.3 4.8 6.3 -0.7 4.2 7.4 5.7
Townsend deprivation index at recruitment 1.8 2.5 6.4 -2.5 0.5 -1.8 -1.4 -1.6 -1.9 -1.2 -1.6 -1.2 1.1 -0.5 -2.0 -1.8
Current tobacco smoking 0.6 1.0 4.8 -2.2 -0.2 -0.4 1.0 0.7 0.7 -0.7 -1.0 0.2 1.7 1.1 0.2 -0.6
Average weekly fortified wine intake 1.2 1.4 3.6 1.5 0.1 1.6 1.2 1.2 1.1 0.8 1.1 0.8 -0.5 1.2 1.9 1.5
Maternal smoking around birth 1.1 1.5 8.4 -2.9 0.9 0.0 -0.0 -0.2 -0.8 -0.1 0.7 0.6 2.9 0.5 -0.9 0.4
Fed-up feelings 2.8 5.1 13.8 -1.6 -0.5 -3.3 -1.4 -1.4 -1.0 -1.3 -3.7 -2.2 -0.3 -2.0 -3.2 -3.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 3.8 -2.0 -1.4 -1.7 -0.9 -0.9 -0.6 -1.1 -1.8 0.0 -1.4 -1.3 -1.4 -1.8
Relative age voice broke 1.9 2.8 11.8 0.1 2.8 -1.0 -2.2 -2.4 -3.4 -0.7 0.4 -0.4 1.4 -0.6 -1.7 -0.2
Taking other prescription medications 0.9 1.3 6.0 -2.4 -0.6 -1.4 -0.8 -0.8 -0.5 0.3 -1.2 0.0 -0.8 -1.9 -0.7 -1.1
Age when periods started (menarche) 2.4 5.9 12.4 0.1 3.3 2.4 0.9 1.0 -0.4 3.5 3.5 1.8 3.5 2.9 -0.7 2.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 2.6 -1.6 -0.5 -0.5 0.3 0.2 0.3 -0.1 -0.4 -0.6 -0.4 -0.0 -0.1 0.0
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.5 15.0 3.6 -2.0 -1.0 -1.8 -1.5 -1.0 -0.5 -1.3 -2.3 -3.9 -3.1 -0.7 -1.4
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.8 0.2 1.0 1.1 0.4 0.5 0.4 0.1 1.3 1.4 -0.2 0.0 -0.5 1.0
Qualifications: CSEs or equivalent 0.6 0.7 4.2 -0.4 1.4 -0.2 0.5 0.1 -0.0 -2.1 -0.2 -0.8 0.5 0.8 1.3 0.1
Serious illness, injury or assault to yourself 0.8 1.0 1.9 -1.0 -0.8 -1.2 -0.7 -0.8 -0.7 -1.0 -1.2 -0.6 -0.9 -1.4 -0.6 -1.2
High blood pressure 1.3 3.6 6.7 -2.2 -2.2 -2.4 -1.5 -1.6 -0.8 -1.8 -2.3 -1.6 -1.9 -2.6 -0.3 -2.3
Hayfever, allergic rhinitis or eczema 0.6 1.2 3.5 0.9 0.9 0.3 1.5 1.6 1.7 1.9 1.0 0.5 -0.7 0.1 -0.4 0.7
Multivitamins +/- minerals 2.6 3.3 9.8 0.4 -0.8 1.3 2.8 2.8 3.1 3.0 1.1 1.3 0.3 0.8 0.5 1.3
Stomach or abdominal pain in last month 1.1 1.4 2.7 0.2 0.1 -1.2 -1.6 -1.6 -1.6 -1.2 -1.2 -0.4 -0.6 -1.6 -0.9 -1.2
Supplements: Glucosamine 0.6 0.7 2.7 1.6 -1.3 -0.1 0.2 0.2 0.4 1.4 -0.6 0.8 -1.1 -0.2 0.9 -0.4
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 4.1 -0.9 -0.4 -1.6 -0.8 -1.1 -1.0 -0.3 -1.6 -0.4 -0.3 -0.3 -2.0 -1.5
Medication: Atenolol 0.5 0.6 1.8 0.0 0.1 -0.9 0.9 1.0 1.3 -0.1 -1.0 -0.9 -0.1 -0.7 -0.2 -1.2
Medication: Levothyroxine sodium 0.5 0.8 4.1 -1.2 -2.0 -0.2 -0.6 -0.5 -0.0 0.8 -0.7 0.6 -0.9 -1.1 -0.4 -0.5
Sitting height 24.6 174.6 416.2 3.1 -11.5 15.6 14.7 17.4 20.4 17.4 9.9 13.5 -2.7 6.4 13.8 11.3
Chronic bronchitis/emphysema (father) 0.9 1.1 2.7 -1.5 1.1 -1.4 -0.7 -1.0 -0.7 -0.6 -1.6 -0.3 -0.5 -1.1 -0.5 -1.3
High blood pressure (mother) 0.4 0.5 2.0 1.3 -1.4 0.5 -0.2 0.0 0.4 0.3 0.3 -0.2 -0.6 -1.3 0.5 0.3
Body mass index (BMI) 1.9 8.1 19.6 0.1 -2.5 -3.4 -1.7 -1.7 -0.5 -2.3 -4.4 -3.2 -2.5 -4.2 -1.7 -4.3
Impedance of leg (left) 2.8 13.6 42.1 0.2 4.2 -3.5 -4.4 -5.0 -6.5 -4.1 -1.6 -3.3 1.0 -0.3 -4.9 -1.8
Leg predicted mass (left) 12.3 65.0 179.6 0.1 -8.4 8.5 9.3 10.8 13.4 9.8 4.3 8.2 -2.0 3.1 9.7 5.3
Trunk fat mass 1.1 4.5 15.1 -0.3 -3.8 0.5 1.8 2.3 3.9 1.7 -1.7 1.7 -2.3 -1.6 1.4 -1.2
Waist circumference 0.8 2.9 10.5 -1.9 -3.2 -1.3 -0.1 0.3 1.4 0.2 -2.5 -0.4 -1.7 -2.3 0.3 -2.2
Number of incorrect matches in round 0.5 0.8 3.0 1.4 1.7 0.1 -0.8 -1.1 -1.1 -1.2 0.1 0.9 -0.2 -0.7 -0.5 0.0
Past tobacco smoking 1.3 2.5 5.2 2.3 -1.6 1.3 1.6 1.8 2.3 2.1 0.9 0.0 -1.3 0.6 1.7 1.2
Alcohol usually taken with meals 0.4 0.6 2.7 0.7 -1.6 -0.2 0.0 0.3 0.7 0.1 -0.7 -0.6 -1.0 0.1 1.2 -0.7
Nervous feelings 0.6 1.1 3.3 -1.5 -0.2 -0.9 -0.2 -0.3 -0.9 1.2 -1.1 1.8 0.7 0.5 -1.5 -1.1
Frequency of tenseness / restlessness in last 2 weeks 3.6 5.7 12.8 -2.5 -2.0 -3.2 -2.3 -2.5 -2.2 -2.1 -3.4 -0.7 -1.4 -1.3 -2.0 -3.6
Hearing difficulty/problems with background noise 0.7 1.0 5.0 0.1 0.5 0.5 -0.2 -0.2 -0.7 2.2 0.9 2.2 0.4 0.6 -0.9 0.8
Hair/balding pattern: Pattern 2 2.0 2.5 7.5 -0.7 0.2 -2.1 -1.3 -1.5 -1.5 -1.3 -2.7 -0.9 -0.6 -1.8 -1.4 -2.4
Had menopause 1.0 1.3 4.5 -0.8 -2.1 1.2 0.3 0.6 0.5 2.1 1.0 1.0 -0.6 -0.0 0.7 1.6
Had other major operations 0.4 0.5 1.7 -1.0 0.7 -1.1 0.2 0.1 0.3 -0.2 -0.6 0.0 -0.3 -1.3 -0.8 -0.8
Forced vital capacity (FVC) 3.0 11.5 19.8 -3.8 -1.4 3.0 3.5 3.9 4.4 4.0 1.7 4.4 0.5 3.6 4.3 2.4
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 12.7 3.6 -2.6 0.3 -0.6 -0.3 0.1 0.3 -0.3 -1.3 -3.4 -1.6 0.6 0.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.2 -1.1 -0.4 -0.3 0.3 0.3 0.5 -0.3 -0.6 0.2 0.1 0.6 0.0 -0.5
Qualifications: None of the above 1.0 2.0 4.3 -1.4 1.3 -1.7 -0.7 -1.1 -1.3 -2.1 -1.8 -2.0 1.3 -0.1 -1.2 -1.4
Financial difficulties in last 2 years 1.1 1.5 4.3 -2.1 -1.6 -1.6 0.3 0.2 0.5 -0.6 -2.1 -0.4 0.7 0.3 -0.6 -1.9
Mouth/teeth dental problems 1.9 2.9 7.3 1.2 -1.4 2.5 1.1 1.4 1.1 2.5 2.7 1.4 -0.1 0.5 1.4 2.5
Heart attack 5.3 6.8 16.0 -1.0 -0.5 -3.5 -2.6 -2.6 -2.2 -1.3 -3.0 -1.0 -2.4 -4.0 -3.3 -3.4
Allergy 1.4 3.2 12.8 -0.1 0.4 -1.3 -2.2 -2.4 -2.5 -3.6 -1.7 -1.6 0.3 -1.1 0.0 -1.7
Pain all over the body in last month 0.3 0.3 1.1 -1.1 0.1 -0.7 0.8 0.6 0.8 0.0 -0.7 0.6 0.1 0.3 0.1 -0.4
Diabetes (self-reported) 0.3 0.5 3.0 -0.9 -1.7 0.1 -0.2 0.1 0.5 0.4 -0.3 -0.3 -0.6 -1.0 -0.1 -0.3
Hayfever/allergic rhinitis (self-reported) 1.7 2.3 7.0 -0.3 0.4 1.1 1.8 1.9 1.8 2.6 1.9 0.0 -0.7 1.4 0.9 2.1
Medication: Ramipril 2.2 2.8 8.7 -0.9 1.2 -2.0 -1.7 -1.5 -1.4 -0.7 -1.3 -1.0 -0.3 -3.0 -2.6 -2.0
Medication: Simvastatin 1.5 2.1 6.9 1.1 2.6 -1.5 -1.3 -1.4 -1.2 -1.6 -0.8 -0.5 -1.0 -2.3 -1.1 -1.2
Fluid intelligence score 1.1 2.2 13.2 0.2 -3.6 -0.3 -1.4 -0.8 -0.5 0.8 -0.9 -0.9 -1.6 -1.5 -2.1 -1.0
Illnesses of siblings 1.7 2.3 15.8 -0.4 4.0 1.0 1.0 0.9 0.4 -0.8 1.3 0.6 2.2 1.2 -0.9 1.2
Neuroticism score 1.4 2.9 9.0 -3.0 -1.0 -2.3 -1.0 -1.0 -1.1 -0.1 -2.7 0.0 -0.2 -1.0 -2.1 -2.6
Weight 4.8 23.6 73.5 0.1 -7.2 4.3 5.2 6.3 8.6 5.9 0.9 4.6 -2.7 0.2 5.4 1.7
Impedance of arm (right) 0.8 3.7 23.3 -0.9 4.8 -0.4 -0.4 -1.0 -2.0 -2.5 0.8 1.7 1.2 1.8 -1.5 0.8
Arm fat percentage (right) 2.1 8.3 22.6 -0.6 -0.7 -4.0 -1.7 -2.0 -1.2 -3.0 -4.8 -2.4 -2.0 -3.8 -2.5 -4.5
Trunk fat-free mass 16.4 94.1 222.0 0.5 -10.2 10.8 10.5 12.4 14.9 13.0 6.3 9.9 -2.1 4.4 11.4 7.5
Hip circumference 2.3 10.1 37.6 0.7 -6.1 1.9 2.9 3.6 5.6 2.8 -0.9 1.9 -3.2 -1.2 3.5 -0.3
Time employed in main current job 0.5 0.5 3.6 1.9 0.4 0.5 -0.1 -0.2 -0.2 -0.9 0.7 -0.1 -0.5 0.2 0.9 0.8
Alcohol intake versus 10 years previously 1.3 1.9 4.2 -2.0 -1.6 0.6 1.8 1.9 2.1 1.5 0.6 1.7 0.8 0.3 0.7 0.7
Father’s age at death 1.0 1.4 4.1 1.8 -0.4 1.6 -0.9 -0.7 -1.1 0.2 2.0 0.6 -0.2 0.3 1.6 1.6
Worrier / anxious feelings 0.6 1.0 3.3 -1.8 -0.4 -0.2 -0.2 -0.1 -0.6 1.8 0.5 1.7 0.2 0.1 -1.7 0.4
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 11.0 -0.9 -2.1 -2.3 -0.7 -0.6 0.3 -0.4 -3.3 -0.7 -2.6 -2.3 -1.4 -3.1
Falls in the last year 0.8 1.1 2.2 -0.3 -0.4 -1.4 -1.1 -1.2 -1.2 -0.1 -1.2 -0.2 -0.9 -1.1 -1.4 -1.5
Hair/balding pattern: Pattern 3 1.4 2.1 6.5 2.6 -1.1 1.7 0.3 0.7 0.9 2.0 1.8 1.0 -1.9 -0.6 0.5 1.7
Number of live births 0.3 0.4 1.4 0.3 -0.4 0.5 0.4 0.2 0.2 -0.8 0.5 -0.4 0.5 0.9 1.2 0.8
Forced expiratory volume in 1-second (FEV1) 2.9 9.6 18.3 -3.7 -1.6 2.8 3.1 3.5 3.9 4.3 1.5 4.2 1.0 3.2 3.1 2.0
Pulse rate 1.5 2.6 12.4 -3.5 1.7 0.2 1.2 0.7 0.3 -0.1 0.9 0.9 2.3 2.6 0.2 1.4
Happiness 1.6 2.0 5.2 -0.8 -0.3 -2.3 -0.7 -0.7 -0.5 -1.1 -2.2 -1.0 -0.1 -1.6 -2.0 -2.3
Noisy workplace 0.3 0.4 1.8 -0.8 0.6 -0.7 -0.1 -0.3 -0.4 -0.6 -0.6 1.4 -0.0 -0.9 0.1 -0.6
Qualifications: A levels/AS levels or equivalent 1.5 3.4 7.6 1.6 -2.3 1.8 1.7 2.1 2.8 2.2 0.8 1.5 -1.5 0.3 2.5 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 2.1 0.5 -0.4 0.4 -0.2 -0.1 -0.2 -0.5 0.7 0.4 0.1 -0.6 -1.5 0.3
Mouth/teeth dental problems: Dentures 0.3 0.6 1.6 -0.2 0.8 0.6 1.1 1.0 1.3 0.4 0.6 0.9 0.9 0.3 0.1 0.6
Asthma 0.7 1.4 6.4 -2.5 -2.3 -0.1 -0.3 -0.1 0.0 1.2 0.4 0.3 -1.9 -1.0 -0.6 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.4 0.2 0.8 -0.9 -1.2 -1.1 -1.0 -1.1 -0.6 -0.1 -0.6 -0.7 -0.1 -1.0
Medication: Cholesterol lowering 2.3 3.6 7.5 0.6 1.6 -2.1 -2.2 -2.3 -1.9 -1.7 -2.1 -1.2 -0.5 -2.7 -1.4 -2.6
Depression (self-reported) 3.6 4.3 9.3 -2.2 0.4 -2.8 -1.7 -1.8 -1.4 -3.1 -2.7 -2.3 -1.3 -1.5 -0.6 -2.9
Medication: Lansoprazole 2.6 3.0 6.4 -1.5 1.8 -2.3 -1.9 -2.0 -2.3 -1.0 -1.5 -0.3 0.1 -1.4 -2.5 -1.8
Prospective memory result 1.0 1.2 5.8 -0.9 2.4 0.3 1.3 1.2 1.2 1.2 0.3 1.0 1.4 0.2 0.1 0.4
Lung cancer (father) 2.1 2.4 5.3 -0.2 -0.1 1.6 1.6 1.6 1.7 2.3 1.7 2.2 0.2 0.8 1.9 1.9
Illnesses of mother 2.3 2.9 5.8 -2.4 -0.0 1.5 1.6 1.7 1.3 1.8 1.9 0.9 1.9 2.4 0.8 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 4.1 13.0 23.4 -2.8 -1.1 3.8 4.0 4.4 4.7 4.7 2.3 4.8 2.1 3.8 3.1 2.8
Pulse wave Arterial Stiffness index 0.3 0.3 1.8 0.7 -0.4 0.0 -0.3 -0.1 0.2 0.7 0.0 -0.1 -1.3 -1.0 -0.6 -0.2
Impedance of arm (left) 0.9 4.1 23.2 -1.1 4.8 -0.3 -0.9 -1.4 -2.5 -2.6 0.8 1.6 1.8 1.7 -2.0 0.7
Arm fat mass (right) 0.9 3.9 12.6 -0.1 -3.5 -0.8 1.2 1.5 3.1 0.5 -2.7 0.0 -2.4 -2.3 0.8 -2.2
Trunk predicted mass 16.4 93.7 222.0 0.4 -10.2 10.8 10.4 12.4 14.9 13.0 6.3 9.9 -2.0 4.4 11.3 7.5
Standing height 20.9 207.0 423.8 0.2 -11.3 17.0 15.4 18.0 20.6 18.6 11.5 17.2 -1.0 9.4 15.9 13.1
Length of working week for main job 0.5 0.5 3.2 -0.2 -0.9 0.3 -0.3 0.0 0.2 0.1 0.4 -0.3 -1.0 -1.8 -1.0 0.1
Exposure to tobacco smoke at home 0.9 1.0 4.5 -2.1 -0.4 -0.9 -1.3 -1.4 -1.6 -0.6 -0.3 0.0 0.0 -0.5 -0.7 -0.4
Breastfed as a baby 1.1 1.4 7.5 -2.7 1.1 -1.2 -1.4 -1.3 -1.8 -0.2 -0.3 0.1 0.1 -0.3 -0.8 -0.5
Tense / ‘highly strung’ 0.8 1.4 6.0 -2.5 -1.0 -1.3 -0.2 -0.3 -0.4 -0.0 -1.5 0.9 -0.3 -0.5 -1.8 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.0 7.1 -1.3 -1.5 -2.3 -1.4 -1.3 -0.8 -0.9 -2.7 -1.0 -1.8 -1.9 -1.8 -2.6
Hair/balding pattern: Pattern 4 1.2 3.0 15.4 3.9 0.3 1.2 1.8 1.7 1.6 2.1 1.4 1.3 -1.1 1.2 0.6 1.4
Birth weight of first child 0.3 0.6 2.7 -1.3 1.6 -0.2 0.3 0.2 0.2 -0.6 -0.4 1.5 0.6 0.3 -0.0 -0.1
Peak expiratory flow (PEF) 6.5 15.1 28.3 -1.1 -3.3 4.4 4.1 4.7 5.3 4.9 2.8 4.9 0.1 3.2 4.2 3.6
Pulse wave reflection index 1.0 1.3 4.7 2.2 -0.9 -0.0 -1.2 -0.8 -0.7 0.6 0.1 -0.4 -1.2 -1.9 -1.7 -0.5
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.2 -1.0 0.8 -1.0 -1.2 -1.2 -1.4 -0.4 -0.7 0.8 0.1 -1.2 -1.5 -1.1
Loud music exposure frequency 1.1 1.2 6.4 -2.5 1.1 -1.2 1.0 0.7 0.8 -0.0 -1.5 0.8 -0.1 0.4 0.5 -0.9
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 5.7 -1.1 -2.4 -0.2 0.0 0.3 0.9 0.4 -0.5 0.1 -2.0 -1.0 1.9 -0.5
Mouth/teeth dental problems: Bleeding gums 4.9 6.4 11.9 -0.9 -0.1 -3.4 -2.7 -3.0 -2.6 -3.4 -3.4 -2.4 -1.7 -1.5 -1.0 -3.5
Blood clot in the leg (DVT) 10.4 13.4 32.1 0.3 -0.5 4.2 4.0 4.2 4.0 5.7 4.2 3.9 2.3 3.5 1.7 4.5
Medication: Paracetamol 1.8 3.0 7.3 -0.6 -0.0 -2.4 -1.8 -1.8 -1.6 -1.4 -1.8 -1.3 -0.1 -2.0 -2.7 -2.3
Headache pain in last month 0.3 0.5 2.6 -0.9 -0.3 0.6 -0.1 0.1 -0.1 0.9 0.5 0.3 1.6 -0.0 -1.3 0.0
Medication for cholesterol, blood pressure or diabetes 1.5 2.4 5.3 -0.1 -1.0 1.6 2.0 2.1 1.8 1.8 1.4 1.1 0.0 2.3 1.0 2.0
Glaucoma (self-reported) 0.8 1.0 2.5 1.6 -0.2 1.4 0.3 0.4 0.4 -0.0 0.8 -0.5 1.5 1.3 1.5 0.9
Gout (self-reported) 0.1 0.1 0.4 -0.3 0.4 0.5 -0.1 -0.0 -0.1 0.3 0.1 0.4 -0.4 -0.6 0.2 0.2
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 7.4 -1.4 -2.7 -0.1 -0.1 -0.0 0.5 0.8 -0.9 0.5 -0.4 -0.7 0.5 -0.4
Medication: Amlodipine 0.6 0.8 5.3 -2.3 0.1 -0.5 -0.6 -0.7 -0.6 -1.0 -0.0 -0.3 -0.8 -1.2 0.7 0.0
Medication: Ventolin 100micrograms inhaler 1.3 1.7 10.8 -3.3 -1.1 -1.3 -0.9 -0.7 -0.5 0.1 -0.6 0.2 -1.7 -1.8 -0.4 -0.6
Birth weight 2.1 4.6 20.0 -1.1 0.8 2.4 1.5 1.7 1.7 3.0 2.2 4.5 1.1 1.7 1.0 2.2
Chronic bronchitis/emphysema (mother) 1.5 1.8 7.0 -0.4 2.0 -1.3 0.1 -0.2 -0.4 -0.0 -1.1 0.2 2.6 0.7 -2.4 -1.4
High blood pressure (siblings) 1.3 1.9 13.5 1.5 -3.7 -0.5 -0.8 -0.6 -0.1 1.0 -1.0 -1.1 -1.2 -1.0 0.3 -1.2
Forced vital capacity (FVC), Best measure 3.8 14.0 26.2 -3.2 -1.3 3.8 4.1 4.6 5.1 4.4 2.3 5.1 1.2 3.8 4.1 3.0
Body fat percentage 2.2 8.7 21.7 -0.1 -0.5 -3.8 -2.2 -2.4 -1.6 -3.2 -4.7 -2.7 -1.8 -3.9 -2.8 -4.5
Leg fat percentage (right) 6.2 22.4 40.3 0.9 0.0 -6.0 -4.6 -5.0 -4.4 -4.8 -6.2 -5.5 -2.2 -5.4 -4.7 -6.3
Arm fat-free mass (right) 12.2 62.5 153.8 0.4 -9.5 8.7 8.4 10.1 12.4 11.0 4.7 7.5 -1.8 2.8 8.9 5.6
Exposure to tobacco smoke outside home 1.8 2.4 6.5 -2.5 -1.0 -2.1 -1.6 -1.6 -1.5 -0.7 -1.6 -0.1 -1.3 -1.0 -1.5 -2.1
Comparative body size at age 10 1.1 2.9 10.6 0.1 -1.2 -2.1 -1.1 -1.4 -0.6 -1.5 -3.3 -0.9 -1.0 -2.1 -0.4 -3.0
Number of full brothers 4.1 5.2 11.9 -1.1 0.7 2.7 2.7 2.5 2.2 2.3 2.3 2.0 2.3 3.5 1.0 2.8
Worry too long after embarrassment 0.9 1.5 4.7 -0.9 -0.2 -1.7 -1.1 -1.1 -1.2 -0.3 -1.9 0.3 -0.7 -0.7 -1.5 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 6.2 -2.1 -0.4 -1.9 0.0 -0.0 0.6 -1.0 -2.5 -0.8 -0.9 -0.2 0.3 -2.2
Wheeze or whistling in the chest in last year 0.5 0.9 4.0 -2.0 -1.3 -0.9 -0.3 -0.1 -0.0 1.1 0.2 -0.1 -1.0 -1.1 -1.4 -0.1
Number of children fathered 0.8 0.9 2.6 1.4 1.0 -0.3 -1.1 -1.0 -0.8 -1.0 -0.4 0.4 -1.3 -1.6 -0.4 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 3.8 -0.2 -1.4 -0.6 -0.1 -0.2 -0.1 2.0 -0.5 0.9 -1.9 0.0 -0.7 0.0
Age at first live birth 0.3 0.6 3.6 1.9 -0.4 0.5 0.3 0.5 0.5 1.0 0.4 0.2 -0.9 0.7 0.7 0.3
Pulse wave peak to peak time 0.7 0.8 2.0 -0.6 -0.3 0.8 1.0 0.9 0.9 0.3 0.4 1.0 1.0 1.3 1.4 0.7
Health satisfaction 1.6 2.0 13.4 -1.0 -0.5 -1.3 -0.3 -0.2 -0.0 0.9 -1.1 0.2 -0.3 -2.4 -3.7 -1.5
Shortness of breath walking on level ground 2.3 2.7 6.3 -2.5 -1.4 -2.2 -1.0 -1.1 -0.7 -1.1 -2.1 -0.9 -0.4 -1.8 -2.1 -2.3
Qualifications: College or University degree 2.2 6.9 21.1 3.0 -1.6 3.3 2.1 2.7 2.6 4.6 2.8 1.6 -0.2 1.9 2.1 3.0
Eye problems/disorders: None of the above 0.9 1.1 2.1 0.3 0.8 1.3 1.4 1.5 1.3 0.1 1.1 0.8 0.8 1.3 0.3 1.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 2.6 1.6 -0.6 -0.0 0.4 0.3 0.7 0.1 -0.9 -0.1 -0.5 0.3 0.1 -0.6
Emphysema/chronic bronchitis 0.3 0.3 0.6 -0.6 0.6 -0.4 0.7 0.5 0.4 0.5 -0.2 0.8 0.6 0.6 0.6 -0.3
Medication for pain relief, constipation, heartburn 3.5 5.9 12.2 0.6 -0.5 3.3 2.5 2.5 2.1 2.4 2.9 1.5 0.7 3.3 2.9 3.5
Neck or shoulder pain in last month 0.6 0.8 3.5 0.4 -1.4 -0.7 -0.6 -0.6 -0.2 1.1 -0.8 -0.0 -1.9 -1.0 0.3 -0.8
Medication: Blood pressure 1.3 2.3 7.3 -0.4 -0.8 -1.7 -1.6 -1.6 -1.1 -1.7 -1.5 -1.2 -1.2 -2.7 -1.0 -2.0
Angina (self-reported) 2.2 2.9 9.3 0.3 -1.2 -2.3 -0.8 -0.7 -0.0 -0.6 -2.4 -1.2 -1.8 -3.0 -1.8 -2.6
Migraine (self-reported) 0.6 0.8 5.7 -1.1 -2.4 0.1 -0.7 -0.5 -0.5 -0.4 0.2 -1.1 0.7 0.4 0.7 0.1
Medication: Ibuprofen 0.4 0.5 1.2 0.1 -0.0 -0.7 -1.1 -1.0 -0.9 -0.8 -0.3 0.0 -0.9 -0.6 0.7 -0.7
Medication: Allopurinol 0.2 0.2 0.6 -0.2 0.5 -0.5 -0.3 -0.4 -0.3 -0.1 -0.7 0.0 -0.7 -0.6 -0.3 -0.8
Medication: Omeprazole 2.5 2.9 9.8 0.2 0.8 -1.1 -2.3 -2.2 -2.3 -1.0 -0.2 -0.6 -1.2 -2.7 -3.1 -0.8
Medication: Seretide 50 evohaler 0.5 0.6 1.6 -1.3 -0.9 0.0 -0.6 -0.5 -0.7 0.3 1.0 -0.3 -0.6 -0.6 -1.1 1.0
Mean time to correctly identify matches 0.8 1.6 9.2 1.3 1.5 -1.1 -0.9 -1.2 -1.1 -3.0 -0.6 -1.3 -0.8 -0.0 -0.4 -0.6
Heart disease (mother) 1.7 2.1 7.3 0.4 -0.6 -2.2 -0.7 -0.9 -0.3 -0.8 -2.5 -0.3 -1.3 -1.8 -1.3 -2.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.8 2.9 0.1 0.6 0.6 1.1 1.0 0.9 0.5 0.4 0.0 0.8 1.7 0.9 1.1
Whole body fat mass 0.9 3.6 12.7 0.1 -3.6 -0.2 1.3 1.7 3.2 0.9 -2.3 0.6 -2.1 -2.0 0.9 -1.8
Leg fat mass (right) 1.2 4.8 13.5 0.8 -3.0 -2.0 -0.6 -0.4 0.9 -0.7 -3.7 -1.7 -2.6 -3.3 -0.5 -3.4
Arm predicted mass (right) 12.1 61.7 153.7 0.3 -9.5 8.6 8.3 10.1 12.4 10.7 4.5 7.4 -1.9 2.7 9.0 5.5
Pulse rate, automated reading 0.7 2.3 17.3 -4.2 1.2 -0.3 -0.4 -0.8 -1.2 -1.5 0.9 0.6 1.7 1.2 -0.2 1.1
Alcohol intake frequency. 0.7 1.6 4.0 -1.6 -0.6 -2.0 -1.4 -1.4 -1.5 -1.1 -1.1 -0.1 -0.7 -1.2 -1.0 -1.3
Comparative height size at age 10 14.0 77.0 185.0 -1.0 -8.4 9.7 9.5 11.1 13.6 9.6 5.2 11.2 -2.1 4.6 11.0 6.7
Number of full sisters 2.3 2.8 4.7 -1.0 -0.5 -2.2 -1.9 -2.1 -1.9 -1.4 -2.1 -1.5 -0.7 -1.6 -1.5 -2.2
Suffer from ‘nerves’ 0.4 0.6 2.4 -1.5 -1.3 -0.9 -0.3 -0.3 -0.4 0.3 -1.0 0.2 -0.6 -0.6 -0.9 -0.7
Overall health rating 2.3 4.8 12.8 -1.9 -0.3 -3.4 -1.2 -1.4 -1.1 -0.9 -3.1 -1.1 -0.9 -2.9 -3.6 -3.0
Chest pain or discomfort 1.6 2.3 5.5 -1.2 -2.4 -1.4 -1.3 -1.1 -0.8 0.4 -1.4 -0.5 -2.2 -2.3 -1.9 -1.2
Had major operations 0.7 0.8 1.9 -1.4 0.3 -0.5 -1.2 -1.2 -1.3 -1.1 -0.3 0.2 1.3 0.0 -1.0 -0.4
Age at last live birth 1.2 1.7 3.9 1.4 -1.2 1.3 1.3 1.5 1.7 1.4 0.7 0.4 0.1 2.0 1.7 0.8
Family relationship satisfaction 0.3 0.4 1.0 0.6 -1.0 -0.7 -0.2 -0.0 0.3 -0.1 -0.8 -0.6 -0.7 -0.7 -0.3 -1.0
Leg pain on walking 0.8 1.0 5.0 -1.0 0.4 -0.4 -0.3 -0.4 -0.5 -0.2 -0.9 0.9 1.7 -0.8 -2.2 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.8 -1.0 1.3 -0.4 0.1 -0.1 0.0 -1.7 -0.1 1.0 0.3 -0.2 0.4 -0.5
Commuting to job workplace: Car/motor vehicle 1.8 2.0 4.8 -0.1 -0.1 -1.7 -1.1 -1.3 -0.9 -1.3 -2.2 -1.0 -1.8 -1.9 -1.3 -1.9
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.4 1.6 0.7 -0.5 -0.6 -0.6 -0.4 0.4 -0.8 -0.8 -1.0 -1.0 -0.0 -0.5
Medication: Aspirin 3.7 4.9 11.2 1.6 0.5 -3.0 -1.5 -1.7 -1.0 -2.1 -3.2 -2.2 -1.7 -2.9 -2.0 -3.4
Supplements: Vitamin C 1.5 1.7 3.8 -1.2 -1.1 0.7 1.8 1.7 1.9 1.0 0.6 1.5 0.4 1.6 1.3 1.0
Knee pain experienced in last month 6.6 10.3 18.3 -2.0 4.2 -4.3 -2.7 -3.4 -4.0 -2.9 -3.5 -2.0 1.2 -1.5 -4.3 -3.6
Hypertension (Self-reported) 1.5 4.1 8.0 -1.9 -2.1 -2.5 -1.6 -1.7 -0.9 -2.2 -2.5 -1.6 -2.0 -2.8 -0.1 -2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 4.1 -0.7 0.6 -0.9 -0.9 -1.0 -1.3 -0.1 -0.3 0.3 0.4 -1.4 -2.0 -0.4
Illnesses of father: Heart disease 3.1 4.2 9.9 0.7 -1.0 -2.3 -2.0 -2.0 -1.3 -2.0 -3.2 -1.6 -2.6 -2.6 0.0 -3.0
Illnesses of siblings: Diabetes 1.8 2.2 14.6 -0.6 -3.8 -0.9 -0.5 -0.5 -0.0 1.0 -1.2 -0.3 -2.5 -0.8 1.6 -0.7
Smoking status: Previous 1.1 1.6 3.9 -1.4 1.6 -0.9 -1.4 -1.6 -2.0 -1.8 -0.5 0.1 0.9 -0.7 -1.3 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 11.9 24.6 68.9 -0.9 -3.0 4.9 6.5 7.1 8.3 5.8 3.0 5.2 -0.1 3.5 5.4 3.8
Whole body fat-free mass 15.0 85.6 216.1 0.4 -9.9 10.1 10.2 12.1 14.7 12.0 5.6 9.4 -2.1 3.9 10.9 6.8
Leg fat-free mass (right) 13.0 69.5 185.0 -0.3 -8.8 8.9 9.5 11.1 13.6 10.2 4.8 8.6 -1.9 3.4 10.0 5.8
Arm fat percentage (left) 2.3 9.0 23.0 -0.7 -0.6 -4.0 -2.1 -2.4 -1.6 -3.3 -4.8 -2.6 -1.7 -3.9 -2.8 -4.7
Average weekly red wine intake 1.0 1.5 4.1 1.2 -0.1 0.9 1.2 1.5 1.9 1.5 -0.3 1.2 -1.0 0.7 2.0 -0.0
Handedness (chirality/laterality): Left-handed 0.6 0.8 4.7 -0.6 0.8 0.0 0.1 -0.0 -0.4 1.2 1.1 2.2 0.4 0.7 -0.3 0.9
Mood swings 0.7 1.3 6.7 -2.6 -1.0 -1.5 -0.2 -0.3 -0.3 -0.3 -1.6 -0.4 0.6 0.2 -0.8 -1.6
Loneliness, isolation 2.4 3.4 9.7 -2.0 -0.6 -2.8 -0.7 -1.0 -0.5 -2.3 -3.1 -1.1 -0.8 -1.2 -1.7 -3.0
Long-standing illness, disability or infirmity 1.4 2.1 5.1 -1.3 -0.9 -2.2 -0.7 -0.7 -0.2 1.2 -2.1 0.4 -1.2 -2.0 -1.6 -2.3
Ever had bowel cancer screening 0.8 0.9 1.9 -0.1 -1.1 -0.8 1.1 0.8 1.2 0.5 -1.4 1.0 0.1 0.3 1.3 -1.2
Diabetes diagnosed by doctor 0.3 0.4 2.1 -1.0 -1.5 -0.3 -0.4 -0.1 0.2 0.5 -0.5 -0.3 0.0 -1.0 -0.6 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 3.6 1.2 -0.6 -1.4 -0.3 -0.4 -0.2 -1.3 -1.5 -1.5 -0.3 0.1 -1.9 -1.7
Friendships satisfaction 1.4 1.8 4.3 0.2 -1.7 -1.7 -0.6 -0.7 -0.1 -1.1 -2.1 -1.8 -1.1 -1.6 -0.3 -1.9
Qualifications: nursing, teaching 0.4 0.6 2.3 0.4 -1.5 -0.8 -0.3 -0.2 0.1 0.3 -0.8 -0.9 -1.4 -0.7 0.2 -0.8
Commuting to job workplace: Walk 2.1 2.3 7.3 -0.2 -0.7 2.2 0.7 1.1 0.8 2.2 2.7 1.0 0.3 1.6 0.9 2.4
Eye problems/disorders: Cataract 0.5 0.6 3.1 0.4 -1.4 -0.5 -0.5 -0.4 -0.1 0.8 -0.5 -0.5 -0.8 -1.8 -0.5 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 4.7 -1.3 1.4 -1.7 -1.8 -2.0 -2.2 -1.9 -1.2 -1.1 0.3 -0.5 -1.8 -1.3
Medication for cholesterol 1.1 1.7 4.4 1.0 0.3 1.7 1.1 1.0 1.1 0.8 1.3 1.5 0.8 2.1 1.8 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.3 0.0 -0.0 -0.3 -0.4 -0.5 -0.3 -0.3 -0.9 0.4 -0.1 -0.8 -1.2 -1.0
Back pain experienced in last month 1.2 1.7 6.6 -1.0 2.4 0.9 1.0 0.7 0.6 0.9 0.5 2.6 1.8 1.3 0.2 0.5
Mineral and other dietary supplements 0.3 0.4 1.6 0.4 0.0 0.9 0.1 0.3 0.2 -0.5 0.9 0.1 1.3 -0.2 -0.9 0.7
Breast cancer (self-reported) 0.3 0.4 1.7 -1.3 -0.5 -0.8 -0.3 -0.2 -0.2 -0.4 -0.9 -0.2 -0.4 -0.5 0.1 -1.0
Asthma (self-reported) 0.7 1.5 8.3 -2.9 -2.3 -0.2 -0.3 -0.1 0.1 1.1 0.1 0.2 -1.9 -0.8 -0.4 0.3
Osteoporosis (self-reported) 0.2 0.3 1.3 -0.9 -0.1 0.7 -0.0 -0.2 -0.3 -0.5 0.2 0.5 1.2 0.4 -0.5 0.4
Osteoarthritis (self-reported) 2.2 2.8 7.6 -0.2 0.5 -2.4 -1.1 -1.5 -1.5 -1.7 -2.8 -1.1 1.1 -0.9 -2.0 -2.7
Medication: Aspirin 3.3 4.3 10.4 1.0 0.3 -2.9 -1.3 -1.5 -0.8 -1.9 -3.0 -1.7 -1.6 -3.0 -2.0 -3.2
Medication: Gliclazide 1.7 1.9 5.7 0.8 -1.7 1.2 1.9 1.9 2.4 0.9 0.3 0.4 -0.5 0.9 2.2 0.5
Illnesses of father: None of the above (group 1) 2.8 3.5 10.7 0.3 0.6 2.5 0.8 1.0 0.1 2.3 3.3 1.9 1.5 2.3 0.2 3.2
Smoking status: Current 0.5 0.8 5.4 -2.3 -0.0 -0.5 0.4 0.1 0.0 -0.6 -0.8 0.2 1.4 1.0 -0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 5.9 -2.4 2.1 -0.9 -0.8 -0.9 -1.5 -0.1 -0.8 0.6 1.4 0.6 -1.5 -0.7
Whole body water mass 14.6 83.5 210.2 0.2 -9.9 9.9 10.1 11.9 14.5 11.9 5.5 9.2 -2.1 3.7 10.8 6.6
Leg predicted mass (right) 13.0 69.4 185.0 -0.3 -8.7 8.9 9.5 11.1 13.6 10.1 4.8 8.6 -1.9 3.4 10.0 5.8
Arm fat mass (left) 0.9 3.5 12.7 -0.2 -3.6 -0.6 1.1 1.4 2.9 0.8 -2.6 0.2 -2.1 -2.3 0.5 -2.1
Number of self-reported non-cancer illnesses 1.1 2.0 8.6 -2.9 -2.2 -1.7 -0.2 -0.4 0.2 0.4 -2.0 0.3 -0.9 -1.2 -0.3 -1.6
Average weekly champagne plus white wine intake 0.3 0.4 2.0 0.6 -1.4 0.3 -0.4 -0.3 -0.1 0.6 0.4 0.8 -0.6 -0.4 -0.9 -0.1
Miserableness 1.1 1.8 5.5 -2.2 -0.3 -1.7 -0.7 -0.8 -0.6 -1.4 -2.4 -1.5 -0.2 0.0 -0.9 -2.0
Guilty feelings 1.8 2.8 10.0 -3.2 -1.4 -2.2 -1.3 -1.3 -1.2 0.5 -2.5 0.1 -0.6 -1.1 -0.4 -2.5
Wears glasses or contact lenses 0.4 0.5 1.1 0.9 1.1 0.7 -0.3 -0.0 -0.6 0.9 1.0 0.9 0.4 -0.3 -0.2 0.7
Ever taken oral contraceptive pill 0.7 0.8 1.6 0.9 0.9 -0.9 -1.0 -1.0 -1.3 -0.8 -0.5 -1.0 -1.2 0.6 -0.2 -0.7
Hearing aid user 1.6 1.8 5.7 1.4 2.4 1.4 0.4 0.4 -0.0 0.5 2.1 1.9 1.4 0.5 0.4 1.5
Mother’s age at death 0.6 0.8 4.3 2.1 0.9 -0.4 -0.7 -0.8 -1.0 -0.2 0.1 0.5 -1.0 -0.1 -1.1 -0.2
Financial situation satisfaction 1.1 1.4 6.6 -2.6 -0.0 -1.1 0.3 0.3 0.2 0.2 -1.2 0.7 0.8 -1.3 -1.9 -1.4
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.9 0.0 0.1 -0.0 -0.3 -0.2 -0.3 0.8 0.2 0.9 -0.2 -0.4 -0.5 0.0
Commuting to job workplace: Public transport 1.0 1.2 4.6 -0.9 -0.4 1.3 -0.0 0.2 -0.2 1.6 2.1 0.6 0.1 0.0 0.7 2.1
Eye problems/disorders: Glaucoma 0.5 0.6 1.6 1.0 1.0 0.3 -0.7 -0.7 -0.8 -1.2 0.3 -1.3 0.8 0.1 0.9 0.2
Medication: Blood pressure 1.8 3.4 11.1 -1.8 -1.7 -2.0 -1.7 -1.5 -1.1 -0.8 -1.7 -1.8 -2.0 -3.3 -1.3 -1.8
Pain type(s) experienced in last month: Hip pain 3.2 4.1 9.8 0.2 -1.4 -2.5 -1.5 -1.7 -0.8 -1.2 -3.1 -1.8 -3.1 -2.5 0.3 -3.0
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.9 0.5 -0.7 -0.7 -0.6 -0.7 -0.7 0.5 -0.4 -0.3 -1.7 -0.2 0.5 -0.4
High cholesterol (Self-reported) 2.0 3.5 5.8 1.6 1.9 -2.0 -2.1 -2.2 -2.2 -2.0 -1.3 -2.3 -1.3 -2.4 -0.6 -1.3
Medication: Bendroflumethiazide 0.5 0.7 3.0 -1.6 -0.9 -0.5 -0.8 -0.7 -0.6 -0.4 -0.0 -0.7 -0.6 -1.7 -0.5 -0.1
Medication: Paracetamol 1.7 2.6 5.1 -0.3 -0.4 -2.2 -1.7 -1.7 -1.3 -1.5 -1.7 -1.3 -1.1 -2.1 -1.8 -2.3
Medication: Lisinopril 3.4 4.3 11.8 -1.0 -0.7 -2.7 -2.1 -2.1 -1.6 -1.6 -2.4 -1.5 -1.7 -3.4 -1.6 -2.8
Medication: Atorvastatin 1.1 1.4 5.7 -0.6 0.8 -1.2 -1.0 -1.0 -0.7 -0.4 -1.1 -0.5 -0.8 -2.4 -1.7 -1.3
Illnesses of father: High blood pressure 1.5 1.9 4.6 0.4 -0.8 -1.7 -1.1 -1.2 -0.7 -1.3 -1.4 -0.9 -1.0 -2.1 -1.8 -2.1
Alcohol drinker status: Never 0.5 0.6 2.7 -1.4 1.7 -0.5 -0.8 -0.8 -0.9 -0.6 0.2 -0.0 -0.1 0.2 0.5 0.1
Ever smoked 0.4 0.7 4.1 -2.0 0.4 -0.4 0.2 0.1 -0.2 -0.5 -0.6 0.6 1.7 1.0 -0.1 -0.6
Basal metabolic rate 12.5 69.2 182.2 0.2 -9.4 8.8 9.3 10.9 13.5 10.8 4.5 8.3 -2.3 3.1 9.8 5.6
Leg fat percentage (left) 5.8 20.9 36.5 0.4 -0.4 -5.9 -4.5 -4.8 -4.3 -4.5 -6.0 -5.3 -2.3 -5.2 -4.5 -6.0
Arm fat-free mass (left) 12.0 60.7 155.9 0.6 -9.1 8.4 8.5 10.2 12.5 10.5 4.3 7.5 -1.9 2.7 8.9 5.3
Number of operations (self-reported) 2.4 3.5 8.1 -2.3 -0.3 -2.3 -2.3 -2.4 -2.5 -1.6 -1.2 -0.9 -0.6 -1.5 -2.9 -1.4
Average weekly beer plus cider intake 0.4 0.6 1.4 -1.2 0.7 -0.5 -0.8 -0.9 -1.1 -0.7 -0.3 -0.8 0.6 0.2 -1.0 -0.2
Irritability 1.1 1.9 4.7 -0.3 -0.2 -1.6 -1.7 -1.5 -2.1 -0.5 -1.6 -0.9 0.5 -0.4 -1.7 -2.2
Risk taking 2.4 3.5 11.9 0.9 -1.5 1.5 3.1 3.0 3.5 1.7 0.2 0.9 0.4 1.4 1.7 0.9
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.7 -0.8 0.0 -0.6 -0.4 -0.4 0.7 0.0 0.5 -0.7 0.0 0.5 -0.2
Fractured/broken bones in last 5 years 0.3 0.4 1.2 -0.1 1.1 0.6 0.5 0.5 0.4 -0.7 0.5 -0.2 0.6 1.0 0.5 0.5
Age started oral contraceptive pill 2.2 2.7 9.1 -0.3 0.9 1.6 1.6 1.7 1.0 3.0 1.8 2.3 0.8 1.4 1.1 2.0
Diastolic blood pressure, automated reading 0.5 1.7 5.8 -1.8 -2.4 -1.1 -0.4 -0.5 -0.0 -1.6 -1.6 -1.1 -1.1 -0.9 1.1 -1.0
Ever depressed for a whole week 0.2 0.2 0.5 -0.6 0.6 -0.7 -0.1 -0.2 -0.1 -0.3 -0.7 0.2 -0.7 0.2 -0.6 -0.6
Unable to work because of sickness or disability 0.8 1.1 2.5 -1.5 0.9 -1.6 0.4 0.2 0.3 -1.3 -1.5 -0.4 0.8 0.3 -1.1 -1.5
Commuting to job workplace: Cycle 3.3 4.0 7.8 0.4 -0.1 2.5 2.3 2.4 2.4 1.0 1.9 1.5 2.0 2.4 2.8 2.0
Myopia 0.6 0.8 3.4 0.1 -0.6 1.3 -0.3 0.2 0.0 1.1 1.9 0.7 -0.3 -1.1 0.1 1.3
Vascular/heart problems diagnosed by doctor 2.5 6.8 13.6 2.0 2.4 3.4 2.2 2.1 1.2 2.1 3.3 2.5 2.5 3.7 1.5 3.5
Cholesterol lowering medication 1.4 2.0 7.6 0.4 1.4 -1.7 -1.1 -1.0 -0.9 -0.8 -1.3 -1.3 -1.5 -2.8 -1.6 -1.3
Medication: Omeprazole (e.g. Zanprol) 2.2 2.7 7.2 0.2 0.6 -1.5 -2.0 -2.0 -1.9 -1.3 -0.8 -0.8 -1.5 -2.7 -2.6 -1.2
Pain experienced in last month 0.9 1.4 3.7 1.3 -1.1 1.2 1.6 1.8 1.9 1.1 0.6 0.1 -0.2 0.7 1.2 1.1
Supplements: Calcium 0.4 0.5 2.1 -1.5 0.1 -0.7 0.5 0.4 0.8 -0.3 -0.8 0.1 -0.6 -0.2 0.9 -0.9
Basal cell carcinoma (self-reported) 1.2 1.4 6.7 0.9 -0.5 -0.8 -1.3 -1.3 -1.4 -1.1 -0.4 1.1 -2.6 -1.0 -0.9 -0.6
Heart attack/myocardial infarction (self-reported) 4.4 5.7 13.7 -1.3 -0.3 -3.2 -2.4 -2.5 -2.1 -1.0 -2.6 -0.6 -2.2 -3.7 -3.1 -3.0
Deep venous thrombosis (DVT) (self-reported) 11.8 15.2 35.4 0.4 -0.5 4.7 4.2 4.4 4.1 6.0 4.5 4.2 2.5 3.9 1.7 4.9
Heart disease (siblings) 0.8 1.0 3.6 -1.2 -1.2 -1.3 -0.3 -0.5 -0.1 -0.1 -1.9 0.7 -0.8 -0.2 0.9 -1.7
Alcohol drinker status: Previous 0.2 0.3 0.9 0.0 -0.6 0.2 0.0 0.1 0.1 1.0 0.7 0.4 -0.5 -0.7 0.1 0.7
Pack years of smoking 1.1 1.7 5.2 -0.9 -1.0 0.6 1.4 1.3 1.5 2.0 0.5 2.3 1.1 1.5 -0.3 0.8
Impedance of whole body 1.5 7.7 26.4 -0.5 5.1 -1.9 -2.7 -3.3 -4.7 -3.6 -0.3 -0.5 1.5 0.7 -3.8 -0.4
Leg fat mass (left) 1.2 4.6 12.1 0.5 -3.5 -1.9 -0.5 -0.3 1.0 -0.4 -3.5 -1.5 -2.6 -3.2 -0.4 -3.2
Arm predicted mass (left) 12.2 62.2 161.3 0.5 -9.3 8.3 8.7 10.3 12.7 10.6 4.3 7.3 -2.1 2.8 9.2 5.4