[Hub]/) : Traits : Asthma (self-reported) :

chr11:60,839,578-62,346,131

Best TWAS P=3.78e-11 · Best GWAS P=3.27e-11 conditioned to 0.0386

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FADS1 0.14 0.16 lasso 2 0.16 7.2e-19 -6.5 6.5 6.5e-11 -0.98 0.01 0.99 FALSE
2 CommonMind Brain Pre-frontal Cortex FEN1 0.07 0.06 lasso 4 0.06 1.1e-07 -6.5 -6.5 1.1e-10 0.98 0.01 0.99 FALSE
3 GTEx Artery Aorta FADS2 0.18 0.17 lasso 3 0.14 3.2e-08 -4.7 -5.4 7.2e-08 0.68 0.16 0.84 FALSE
4 GTEx Artery Tibial FADS2 0.08 0.02 lasso 4 0.02 6.9e-03 -5.9 -5.4 7.8e-08 0.80 0.01 0.97 FALSE
5 GTEx Artery Tibial TMEM258 0.08 0.05 lasso 5 0.02 1.1e-02 -6.5 -6.5 8.8e-11 0.97 0.01 0.98 FALSE
6 GTEx Brain Cerebellum FADS1 0.35 0.24 enet 16 0.30 2.1e-09 -6.3 6.0 1.7e-09 -0.92 0.02 0.98 FALSE
7 GTEx Brain Cerebellum FADS3 0.26 0.18 lasso 4 0.14 5.7e-05 -6.3 6.5 1.0e-10 -0.93 0.02 0.89 FALSE
8 GTEx Cells Transformed fibroblasts TMEM258 0.15 0.05 enet 15 0.07 1.1e-05 -5.9 -5.2 2.7e-07 0.78 0.03 0.97 FALSE
9 GTEx Colon Transverse FADS2 0.18 0.11 lasso 7 0.16 8.1e-08 -4.7 -6.3 3.0e-10 0.76 0.04 0.96 FALSE
10 GTEx Esophagus Muscularis FADS2 0.32 0.30 lasso 6 0.31 3.7e-19 -4.7 -5.2 1.6e-07 0.71 0.94 0.06 FALSE
11 GTEx Heart Left Ventricle FADS2 0.17 0.12 enet 3 0.13 1.5e-07 -5.1 -5.5 3.7e-08 0.71 0.23 0.77 FALSE
12 GTEx Muscle Skeletal FADS2 0.08 0.04 lasso 2 0.03 5.9e-04 -6.3 -6.3 2.3e-10 0.90 0.03 0.96 FALSE
13 GTEx Pancreas FADS1 0.17 0.13 lasso 6 0.12 1.2e-05 -6.3 6.5 7.3e-11 -0.92 0.02 0.98 FALSE
14 GTEx Spleen FADS2 0.30 0.27 lasso 3 0.27 1.6e-07 -4.7 -5.4 5.4e-08 0.72 0.08 0.90 FALSE
15 NTR Blood C11orf10 0.06 0.08 bslmm 399 0.08 1.3e-24 -5.9 -6.3 3.6e-10 0.92 0.05 0.95 FALSE
16 ROSMAP Brain Pre-frontal Cortex TMEM258 0.14 0.16 lasso 4 0.15 4.7e-19 -5.9 -5.9 3.8e-09 0.94 0.05 0.95 FALSE
17 ROSMAP Brain Pre-frontal Cortex FADS1 0.08 0.08 enet 10 0.09 1.5e-11 -6.5 6.3 3.9e-10 -0.97 0.01 0.99 FALSE
18 YFS Blood FADS1 0.11 0.08 lasso 8 0.09 6.1e-29 -4.7 -5.7 9.5e-09 0.77 1.00 0.00 FALSE
19 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FADS1 0.06 0.03 lasso 4 0.04 7.4e-03 -6.3 6.6 3.8e-11 -0.83 0.01 0.77 TRUE
20 The Cancer Genome Atlas Colon Adenocarcinoma FADS2 0.30 0.21 lasso 2 0.22 6.7e-13 -4.7 -5.6 2.4e-08 0.76 0.66 0.34 FALSE
21 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FADS2 0.26 0.29 enet 15 0.29 2.9e-33 -4.7 -5.5 4.1e-08 0.73 1.00 0.00 FALSE
22 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FADS2 0.33 0.27 lasso 9 0.35 9.3e-21 -4.7 -5.9 4.1e-09 0.79 0.41 0.59 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma FADS1 0.05 0.05 blup 53 0.04 6.8e-05 -5.0 5.3 9.6e-08 -0.87 0.04 0.96 FALSE
24 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FADS2 0.02 0.01 blup 71 0.02 1.9e-03 -6.3 -5.7 1.5e-08 0.91 0.02 0.78 FALSE
25 The Cancer Genome Atlas Rectum Adenocarcinoma FADS2 0.47 0.34 lasso 5 0.30 7.9e-08 -4.7 -5.3 1.4e-07 0.68 0.04 0.94 FALSE
26 The Cancer Genome Atlas Stomach Adenocarcinoma FADS2 0.15 0.05 blup 71 0.11 2.5e-08 -4.7 -6.1 1.4e-09 0.72 0.04 0.95 FALSE
27 The Cancer Genome Atlas Thyroid Carcinoma C11orf10 0.02 0.02 blup 44 0.02 1.8e-03 -5.1 -6.2 4.9e-10 0.95 0.02 0.73 FALSE
28 The Cancer Genome Atlas Thyroid Carcinoma FADS2 0.30 0.33 lasso 8 0.33 5.6e-33 -4.7 -5.6 2.7e-08 0.71 1.00 0.00 FALSE