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chr11:60,839,578-62,346,131

Best TWAS P=3.78e-11 · Best GWAS P=3.27e-11 conditioned to 0.0386

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-6.5	6.5	6.5e-11	-0.98	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-6.5	-6.5	1.1e-10	0.98	0.01	0.99	FALSE
3	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	-4.7	-5.4	7.2e-08	0.68	0.16	0.84	FALSE
4	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	-5.9	-5.4	7.8e-08	0.80	0.01	0.97	FALSE
5	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-6.5	-6.5	8.8e-11	0.97	0.01	0.98	FALSE
6	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	-6.3	6.0	1.7e-09	-0.92	0.02	0.98	FALSE
7	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-6.3	6.5	1.0e-10	-0.93	0.02	0.89	FALSE
8	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	-5.9	-5.2	2.7e-07	0.78	0.03	0.97	FALSE
9	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	-4.7	-6.3	3.0e-10	0.76	0.04	0.96	FALSE
10	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	-4.7	-5.2	1.6e-07	0.71	0.94	0.06	FALSE
11	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	-5.1	-5.5	3.7e-08	0.71	0.23	0.77	FALSE
12	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-6.3	-6.3	2.3e-10	0.90	0.03	0.96	FALSE
13	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	-6.3	6.5	7.3e-11	-0.92	0.02	0.98	FALSE
14	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	-4.7	-5.4	5.4e-08	0.72	0.08	0.90	FALSE
15	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	-5.9	-6.3	3.6e-10	0.92	0.05	0.95	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-5.9	-5.9	3.8e-09	0.94	0.05	0.95	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-6.5	6.3	3.9e-10	-0.97	0.01	0.99	FALSE
18	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	-4.7	-5.7	9.5e-09	0.77	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	-6.3	6.6	3.8e-11	-0.83	0.01	0.77	TRUE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	-4.7	-5.6	2.4e-08	0.76	0.66	0.34	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	-4.7	-5.5	4.1e-08	0.73	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	-4.7	-5.9	4.1e-09	0.79	0.41	0.59	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	-5.0	5.3	9.6e-08	-0.87	0.04	0.96	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	-6.3	-5.7	1.5e-08	0.91	0.02	0.78	FALSE
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	-4.7	-5.3	1.4e-07	0.68	0.04	0.94	FALSE
26	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	-4.7	-6.1	1.4e-09	0.72	0.04	0.95	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-5.1	-6.2	4.9e-10	0.95	0.02	0.73	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	-4.7	-5.6	2.7e-08	0.71	1.00	0.00	FALSE