Best TWAS P=1.68e-09 · Best GWAS P=2.26e-09 conditioned to 0.0581
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ORMDL3 | 0.09 | 0.08 | enet | 10 | 0.06 | 4.2e-08 | 5.1 | 5.4 | 8.0e-08 | 0.82 | 0.10 | 0.90 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | ORMDL3 | 0.24 | 0.09 | enet | 21 | 0.07 | 7.8e-06 | 5.1 | 6.0 | 1.7e-09 | 0.81 | 0.01 | 0.99 | TRUE |
3 | GTEx | Lung | GSDMB | 0.07 | 0.07 | lasso | 4 | 0.05 | 1.5e-04 | 5.1 | 5.3 | 1.2e-07 | 0.86 | 0.03 | 0.94 | FALSE |
4 | GTEx | Lung | ORMDL3 | 0.16 | 0.13 | enet | 15 | 0.14 | 1.6e-10 | 5.6 | 5.9 | 4.2e-09 | 0.91 | 0.01 | 0.99 | FALSE |
5 | GTEx | Spleen | ORMDL3 | 0.40 | 0.44 | enet | 11 | 0.39 | 5.7e-11 | 5.1 | 5.3 | 1.4e-07 | 0.91 | 0.02 | 0.98 | FALSE |
6 | GTEx | Whole Blood | GSDMB | 0.15 | 0.10 | lasso | 4 | 0.10 | 4.5e-09 | 5.6 | 5.4 | 7.8e-08 | 0.92 | 0.02 | 0.98 | FALSE |
7 | NTR | Blood | GSDMB | 0.09 | 0.10 | enet | 16 | 0.12 | 3.8e-36 | 6.0 | 5.1 | 2.8e-07 | 0.91 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GSDMB | 0.06 | 0.05 | enet | 7 | 0.05 | 2.2e-06 | 5.3 | 5.6 | 2.1e-08 | 0.91 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | GSDMB | 0.05 | 0.07 | blup | 39 | 0.05 | 1.4e-06 | 5.4 | 5.3 | 1.1e-07 | 0.90 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IKZF3 | 0.03 | 0.01 | blup | 43 | 0.02 | 1.3e-02 | 5.5 | -5.7 | 9.4e-09 | -0.80 | 0.01 | 0.66 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ZPBP2 | 0.08 | 0.09 | enet | 5 | 0.10 | 6.1e-08 | 5.3 | -5.2 | 1.6e-07 | -0.90 | 0.05 | 0.94 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | GSDMB | 0.08 | 0.08 | blup | 40 | 0.09 | 6.6e-09 | 5.3 | 5.4 | 6.1e-08 | 0.86 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | ORMDL3 | 0.08 | 0.13 | blup | 37 | 0.15 | 3.8e-14 | 5.1 | 5.2 | 2.2e-07 | 0.88 | 0.02 | 0.98 | FALSE |