Hub : Genes

ORMDL3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0900 0.0280 9.3e-08 0.084 0.044 0.063 0.027 0.009 2.1e-10 3.7e-06 4.2e-08 2.6e-04 2.7e-02
2 GTEx Breast Mammary Tissue 0.1690 0.0580 5.3e-04 0.039 NA 0.057 NA 0.024 4.3e-03 NA 7.2e-04 NA 2.1e-02
3 GTEx Breast Mammary Tissue (Female) 0.0996 0.0700 8.0e-02 0.037 NA 0.003 NA -0.004 2.9e-02 NA 2.6e-01 NA 4.5e-01
4 GTEx Cells Transformed fibroblasts 0.2400 0.0670 1.8e-07 0.094 NA 0.068 NA 0.045 1.7e-07 NA 7.8e-06 NA 2.5e-04
5 GTEx Esophagus Mucosa 0.0890 0.0570 9.0e-03 0.008 NA 0.003 NA 0.000 8.8e-02 NA 1.8e-01 NA 3.3e-01
6 GTEx Lung 0.1610 0.0461 9.4e-10 0.127 NA 0.135 NA 0.054 5.8e-10 NA 1.6e-10 NA 5.7e-05
7 GTEx Skin Sun Exposed Lower leg 0.0440 0.0250 8.3e-03 0.018 NA 0.003 NA 0.005 1.1e-02 NA 1.8e-01 NA 1.1e-01
8 GTEx Spleen 0.3960 0.0960 3.4e-07 0.435 NA 0.387 NA 0.032 1.7e-12 NA 5.7e-11 NA 5.1e-02
9 GTEx Thyroid 0.1770 0.0630 7.9e-04 0.008 NA 0.020 NA 0.038 7.6e-02 NA 1.1e-02 NA 6.4e-04
10 GTEx Whole Blood 0.1840 0.0480 9.4e-11 0.117 NA 0.127 NA 0.136 6.3e-11 NA 1.0e-11 NA 1.8e-12
11 NTR Blood 0.1036 0.0252 0.0e+00 0.096 0.075 0.118 0.093 0.090 3.0e-29 4.1e-23 4.4e-36 2.2e-28 1.3e-27
12 YFS Blood 0.3092 0.0422 0.0e+00 0.357 0.409 0.445 0.436 0.449 4.1e-123 1.7e-146 2.0e-163 4.9e-159 2.2e-165
13 TCGA Kidney Renal Clear Cell Carcinoma 0.0136 0.0092 8.1e-03 0.011 0.005 0.005 NA 0.000 1.9e-02 8.5e-02 8.8e-02 NA 3.5e-01
14 TCGA Lung Squamous Cell Carcinoma 0.0342 0.0215 8.4e-05 0.039 0.030 0.025 NA 0.039 2.8e-05 1.9e-04 6.6e-04 NA 2.9e-05
15 TCGA Thyroid Carcinoma 0.0810 0.0310 3.2e-14 0.130 0.147 0.134 NA 0.132 1.2e-12 3.8e-14 5.5e-13 NA 9.1e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bipolar Disorder (2018) 5.0 8.0 14.4 3.3 -2.3 0.0 2.9 2.1 3.3 1.3 3.8 -1.3 3.6 2.6 2.8 3.4 3.2 3.7
Bipolar Disorder or Schizophrenia 3.9 9.5 14.4 3.3 -2.4 0.0 2.2 2.3 3.0 3.4 3.8 -2.6 3.8 3.1 3.2 3.7 3.5 3.8
Depressed Affect (Nagel 2018) 2.1 4.5 13.8 2.6 -3.1 0.0 3.7 2.4 3.0 -1.2 2.5 0.3 1.7 -0.3 0.2 1.5 1.8 2.6
Depression (Nagel 2018) 0.8 1.2 3.2 1.4 -1.2 0.0 1.8 1.2 1.2 -1.2 1.3 0.3 1.0 -0.6 -0.5 0.8 0.6 1.5
Intelligence (Savage-Jansen 2018) 0.5 1.6 3.1 -1.5 1.7 0.0 -1.6 -1.2 -1.5 0.8 -1.3 -1.7 -1.2 -0.9 -0.9 -0.7 -1.1 -1.1
Neuroticism (Nagel 2018) 0.7 1.7 4.8 1.2 -2.2 0.0 1.8 1.6 1.4 -1.3 1.4 -0.6 1.0 -1.0 -0.8 0.9 1.1 1.6
Schizophrenia (2018) 1.6 3.3 11.4 1.5 -1.2 0.0 0.5 1.3 1.3 3.4 1.8 -2.2 1.9 1.9 1.8 2.1 1.9 1.9
Schizophrenia vs Biploar Disorder 4.2 5.5 10.1 -2.8 2.5 0.0 -3.2 -2.9 -2.7 -0.7 -2.8 -0.9 -2.5 -1.7 -1.9 -2.2 -2.6 -2.9
Worry (Nagel 2018) 0.8 1.6 10.3 -0.9 -0.6 0.0 -0.7 -1.3 -0.8 -3.2 -0.7 -0.7 -0.9 -1.8 -1.7 -0.7 -0.7 -0.5
Alzheimer’s Disease (in mother) 1.5 1.7 3.3 -0.9 1.3 0.0 -0.1 -1.6 -0.8 -0.4 -1.5 0.4 -1.8 -1.8 -1.7 -1.7 -1.7 -1.4
Alzheimer’s Disease (in father) 0.6 0.7 2.8 1.1 -1.7 0.0 1.5 0.7 1.1 0.6 0.6 0.6 0.5 -0.3 -0.4 -0.1 0.5 0.7
Alzheimer’s Disease (including proxy) 1.0 1.4 4.3 -0.6 0.4 0.0 0.6 -0.9 -0.4 -0.5 -1.3 0.7 -1.5 -2.1 -1.9 -1.8 -1.4 -1.1
Crohns Disease (2017) 17.2 37.7 66.3 -4.8 5.6 0.0 -4.5 -5.6 -5.8 -4.6 -6.7 3.1 -7.4 -8.1 -8.1 -7.7 -7.6 -6.9
Irritable Bowel Disease (IBD) 24.2 57.7 95.3 -5.6 7.5 0.0 -5.2 -7.3 -6.9 -6.0 -8.4 3.7 -9.1 -9.8 -9.6 -9.5 -9.5 -8.9
Ulcerative Colitis (UC) 17.7 33.2 52.2 -4.0 6.3 0.0 -4.0 -5.7 -5.1 -4.6 -6.5 3.3 -6.9 -6.9 -6.7 -7.2 -7.2 -7.0
Major Depression (MDD) 1.6 2.0 4.2 1.5 -1.7 0.0 1.6 2.1 1.5 0.8 1.8 0.1 1.5 1.0 1.0 1.4 1.6 1.8
Reaction Time 1.0 1.9 4.2 1.3 -2.0 0.0 1.9 -0.3 1.4 1.9 1.8 0.5 1.4 0.4 0.3 1.1 1.6 2.0
Verbal and Numeric Reasoning (VNR) 0.9 2.1 3.5 -1.4 1.9 0.0 -1.7 -1.4 -1.6 1.2 -1.5 -1.4 -1.6 -1.5 -1.7 -1.3 -1.4 -1.2
Breast Cancer 0.7 1.7 5.1 -0.3 -1.3 0.0 -0.5 -1.3 0.5 0.1 1.4 -2.3 1.7 1.4 0.9 1.8 1.8 1.5
Ovarian Cancer 0.6 0.8 3.7 -0.2 -0.4 0.0 -0.6 0.4 0.2 1.9 0.4 -1.5 0.8 1.2 1.2 1.0 0.7 0.4
Prostate Cancer 0.3 0.5 1.7 0.7 -0.4 0.0 0.3 0.1 0.8 1.3 0.7 0.9 0.7 0.9 0.7 0.0 0.7 0.7
Age at First Birth 0.7 1.1 7.0 -0.7 -0.6 0.0 -1.8 -0.9 -1.2 -2.6 -0.5 -1.4 -0.1 -0.4 -0.3 -0.1 -0.5 -0.5
Bipolar Disorder (2011) 1.7 1.6 6.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 2.0 2.6 2.3 2.2
Body Mass Index (BMI) (2010) 0.8 1.1 2.5 -0.0 1.1 0.0 -0.7 -0.2 -0.6 -0.4 -1.2 1.5 -1.5 -1.2 -1.3 -1.6 -1.2 -1.3
Coronary Artery Disease (CAD) 0.4 0.5 1.5 -0.9 -0.1 0.0 0.0 -0.6 -0.4 1.2 -0.8 0.3 -0.8 -0.9 -1.0 -1.1 -0.3 -0.7
Crohns Disease (2012) 10.0 16.1 28.1 -3.1 4.4 0.0 -3.1 -3.8 -3.5 -3.4 -4.1 3.7 -4.5 -5.0 -5.3 -4.9 -4.6 -4.1
Mean Putamen Volume 1.3 1.5 4.1 0.5 -1.4 0.0 0.2 0.8 0.8 1.8 0.8 -1.3 1.0 2.0 1.8 1.2 1.6 0.9
Fasting Glucose 1.2 1.4 4.2 1.1 0.5 0.0 1.0 1.1 1.1 1.4 1.0 0.4 1.1 1.9 2.0 1.2 1.2 0.8
HbA1C 0.9 1.0 3.0 -0.8 1.3 0.0 -0.4 0.6 -0.6 1.6 -0.8 1.7 -0.8 -1.0 -1.3 -1.1 -0.8 -0.8
HDL Cholesterol 16.7 27.8 43.9 -5.6 2.9 0.0 -6.0 -4.3 -6.0 -6.6 -6.3 0.2 -5.8 -5.8 -5.8 -5.8 -5.5 -6.1
LDL Cholesterol 0.2 0.3 2.0 0.1 0.6 0.0 0.0 0.7 -0.4 -1.4 -0.6 0.9 -0.5 0.0 0.1 -0.5 -0.4 -0.5
Lupus 10.4 15.7 32.7 -5.5 1.9 0.0 -5.7 -3.8 -5.6 -2.6 -4.5 -3.2 -4.0 -3.1 -3.5 -3.5 -3.9 -4.5
Neuroticism (2016) 0.7 1.0 5.8 1.1 -1.3 0.0 1.1 2.4 0.8 -0.5 1.0 0.6 0.7 -0.1 -0.0 0.5 0.8 1.2
Primary Biliary Cirrhosis 19.9 28.3 40.6 -5.0 5.0 0.0 -6.4 -3.1 -6.0 -5.7 -5.9 0.2 -5.8 -6.3 -6.0 -5.7 -6.2 -6.3
Rheumatoid Arthritis 8.0 11.0 21.1 -2.5 2.3 0.0 -2.8 -3.3 -3.5 -3.5 -3.6 1.3 -3.8 -4.6 -4.1 -3.6 -4.3 -3.5
Schizophrenia (2014) 1.0 2.2 6.2 0.9 -0.7 0.0 -0.4 0.9 0.8 2.5 1.3 -2.2 1.5 1.9 1.8 1.9 1.4 1.4
Triglycerides 1.1 1.7 5.2 0.8 -0.6 0.0 1.2 2.3 1.2 0.6 1.4 0.1 1.6 1.6 1.5 1.4 1.8 1.5
Type 2 Diabetes (T2D) (2012) 1.8 2.1 3.5 1.7 -0.3 0.0 1.8 1.9 1.5 1.8 1.6 0.3 1.7 1.6 1.6 1.1 1.4 1.5
Ulcerative Colitis 16.0 23.1 32.6 -4.0 5.3 0.0 -3.4 -4.3 -4.3 -4.6 -5.5 4.5 -5.7 -5.2 -5.4 -5.7 -5.6 -5.6
Blood Eosinophil Count 2.7 20.5 92.4 7.8 -0.8 0.0 9.6 5.6 6.5 0.4 3.9 6.4 2.1 -0.9 1.0 1.6 1.0 3.9
Blood Platelet Count 1.6 18.0 49.8 -4.4 3.9 0.0 -4.1 -3.7 -5.2 -7.1 -4.9 1.0 -4.4 -3.0 -2.6 -4.0 -5.0 -5.4
Blood Red Count 2.0 19.7 130.0 4.7 3.4 0.0 4.7 1.1 4.8 11.4 3.0 3.0 2.4 4.5 4.7 2.4 2.7 2.6
Blood White Count 78.0 578.2 1082.4 20.5 -26.3 0.0 25.2 14.2 24.5 11.4 31.0 -13.5 30.5 21.9 23.2 31.3 29.0 32.9
Heel T-Score 0.5 4.3 9.4 -1.9 2.6 0.0 -2.2 -3.1 -1.8 1.0 -2.7 0.7 -2.6 -1.3 -1.5 -2.4 -2.0 -2.8
BMI 0.5 2.6 5.6 -0.4 1.0 0.0 -1.9 0.4 -1.4 1.4 -2.0 1.1 -2.1 -1.8 -1.6 -2.4 -2.1 -2.2
Height 0.3 6.6 42.2 1.7 -6.5 0.0 0.2 -0.7 0.8 -4.1 2.6 -2.5 2.3 0.3 0.8 2.7 1.8 2.7
Waist Hip Ratio (WHR) 0.2 0.7 3.3 -1.0 0.6 0.0 -0.2 -1.1 -0.7 -1.6 0.1 -1.8 0.2 -0.7 -0.6 0.3 -0.1 0.4
Systolic Blood Pressure 0.2 0.8 2.7 1.5 -0.8 0.0 1.6 -0.4 1.0 -1.6 0.9 0.9 0.4 -0.3 0.0 0.4 0.2 0.9
Smoking Status 1.6 3.9 16.0 1.9 -0.7 0.0 2.7 2.5 2.5 4.0 1.9 0.3 1.6 0.9 0.9 1.3 2.1 2.1
Allergy or Eczema 15.4 40.6 65.4 7.1 -5.7 0.0 8.1 6.2 7.7 4.1 7.8 -0.9 7.2 5.8 6.2 7.1 7.0 7.9
Cardiovascular Disease 0.4 1.3 10.2 1.1 0.1 0.0 1.7 -0.0 1.0 0.0 0.1 3.2 -0.4 -1.5 -0.9 -0.9 -0.7 0.2
Hypothyroidism (self reported) 2.0 4.6 12.3 3.5 -1.8 0.0 3.3 3.4 3.0 -0.1 2.4 0.5 2.2 0.4 0.9 1.7 1.5 2.4
Respiratory disease 79.8 177.7 265.7 12.9 -11.9 0.0 12.6 12.1 14.4 10.2 16.0 -5.1 16.3 14.3 14.4 15.9 16.3 16.2
Type 2 Diabetes (T2D) (2018) 2.3 4.2 9.2 2.0 -1.0 0.0 1.9 2.6 2.2 3.0 2.3 -1.7 2.2 1.9 1.9 2.0 2.3 2.3
Lung FEV1/FVC ratio 3.9 20.0 34.6 -4.7 5.9 0.0 -4.0 -4.2 -4.5 0.8 -5.3 1.8 -5.3 -4.8 -5.3 -5.4 -5.0 -4.9
Lung FVC 2.3 11.8 32.1 -4.3 -0.9 0.0 -4.2 -3.0 -4.2 -5.7 -3.6 -0.6 -3.4 -3.2 -3.6 -3.2 -3.3 -3.6
Neuroticism 0.4 1.0 4.4 0.8 -2.1 0.0 1.6 0.2 0.9 -0.9 0.8 -0.1 0.5 -1.2 -1.1 0.3 0.6 1.3
Chronotype (morning person) 0.5 1.2 3.6 -1.0 1.9 0.0 -1.3 0.3 -1.3 -0.5 -1.5 -0.4 -1.3 0.1 0.3 -1.0 -1.1 -1.7
Hair Pigment 0.0 1.3 9.7 -1.4 -3.1 0.0 -1.0 -0.8 -0.7 -1.1 0.4 -1.8 0.4 -0.4 -0.5 0.2 0.6 0.4
Tanning 0.1 1.8 3.7 1.2 -1.9 0.0 0.9 1.9 1.2 -0.4 1.5 -1.3 1.7 0.9 1.2 1.7 1.3 1.4
Hand grip strength (left) 0.6 1.7 3.8 1.6 -1.9 0.0 0.9 0.9 1.1 0.2 1.6 0.4 1.5 1.3 1.1 1.6 1.4 1.8
Number of treatments/medications taken 3.9 6.9 11.0 2.8 -2.8 0.0 3.2 2.6 3.3 0.7 3.3 0.0 3.1 2.1 2.5 3.1 3.0 3.3
Average weekly spirits intake 0.3 0.4 1.6 0.2 -0.8 0.0 0.9 0.7 0.5 -1.0 0.6 1.3 0.3 -0.4 -0.2 0.2 0.3 0.8
Sensitivity / hurt feelings 0.2 0.3 1.8 0.6 -0.3 0.0 0.5 0.2 0.6 1.4 0.4 -0.1 0.4 -0.1 -0.1 0.4 0.4 0.6
Frequency of depressed mood in last 2 weeks 1.7 2.4 6.9 2.0 -1.5 0.0 2.6 1.4 2.2 -0.0 2.1 0.3 1.5 0.3 0.6 1.4 1.5 2.1
Hearing difficulty/problems: Yes 0.4 0.7 4.6 -0.9 0.2 0.0 -1.2 0.3 -0.8 0.9 -0.4 -2.2 -0.1 -0.8 -0.6 -0.1 -0.3 -0.4
Relative age of first facial hair 0.1 0.2 0.8 0.3 -0.9 0.0 0.1 0.1 0.2 -0.3 0.5 0.3 0.6 0.2 0.1 0.5 0.6 0.6
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 2.0 0.7 -1.0 0.0 1.0 0.3 0.4 -1.4 0.3 -1.0 0.1 0.1 0.3 0.1 -0.0 -0.1
Ever used hormone-replacement therapy (HRT) 0.3 0.3 1.4 -0.1 -0.7 0.0 0.7 0.8 0.8 1.2 0.3 0.6 0.1 0.0 -0.1 0.0 0.6 0.5
Ever had hysterectomy (womb removed) 0.5 0.6 2.3 0.0 -0.1 0.0 -0.1 -0.3 -0.4 0.9 -0.8 1.5 -0.9 -0.9 -0.9 -1.0 -0.8 -0.7
Systolic blood pressure, automated reading 0.2 0.6 4.7 0.3 -0.1 0.0 0.1 -0.1 -0.4 -2.2 -0.6 0.6 -0.9 -0.9 -0.7 -0.7 -0.9 -0.6
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.9 -0.6 0.2 0.0 -0.6 -0.1 -0.9 -1.4 -0.8 -0.2 -0.9 -1.2 -1.4 -1.1 -0.9 -0.9
Angina 0.4 0.6 2.4 0.8 1.5 0.0 0.5 0.6 0.1 -0.2 -0.7 1.6 -0.7 -0.0 0.3 -0.7 -0.8 -0.8
Medication for hormone replacement therapy 0.6 0.7 2.0 0.1 -0.4 0.0 -0.1 -0.0 0.2 -0.5 0.8 -1.3 0.9 1.4 1.3 1.2 1.1 0.8
Vitamin and mineral supplements 2.9 3.9 6.4 -2.0 2.2 0.0 -1.4 -2.0 -2.1 0.3 -2.4 1.0 -2.5 -2.0 -2.1 -2.5 -2.5 -2.3
Supplements: Zinc 0.3 0.4 2.4 -0.0 -1.5 0.0 0.7 0.2 0.8 0.2 0.5 0.7 0.3 -0.3 -0.4 0.0 0.6 0.7
Medication: Co-codamol 1.0 1.1 3.0 -0.2 0.2 0.0 -0.4 -1.1 -0.5 -1.7 -0.8 1.7 -0.9 -1.4 -1.1 -1.3 -1.4 -1.0
Medication: Metformin 1.4 1.9 3.5 1.5 -0.9 0.0 1.1 1.5 1.4 0.9 1.8 -0.9 1.8 1.3 1.2 1.7 1.9 1.9
Diabetes (father) 1.7 2.2 5.1 1.3 -1.5 0.0 1.3 0.8 1.6 0.3 1.5 -0.6 1.7 2.1 2.1 1.5 2.3 1.5
Diabetes (mother) 1.3 1.6 5.4 -0.9 -0.0 0.0 -1.2 -0.9 -1.5 0.2 -1.4 -0.4 -1.4 -2.0 -2.3 -1.7 -1.1 -1.3
Severe depression (siblings) 0.6 0.7 1.9 1.1 -0.0 0.0 1.1 0.5 1.1 1.4 1.1 0.3 0.8 0.3 0.4 0.8 0.7 1.1
Pack years adult smoking proportion 0.4 0.7 2.2 0.8 -1.5 0.0 0.3 -0.6 0.9 -0.2 0.7 0.0 0.8 1.0 1.1 0.9 1.2 0.8
Impedance of leg (right) 0.8 4.0 6.8 2.4 -1.0 0.0 2.5 1.7 2.6 -0.1 2.3 -0.2 2.3 2.3 2.6 2.5 2.1 2.1
Leg fat-free mass (left) 0.2 0.8 3.2 0.1 -1.5 0.0 -0.8 -0.1 -0.5 0.1 -0.4 0.7 -0.8 -1.8 -1.6 -1.1 -0.8 -0.3
Trunk fat percentage 0.2 0.7 3.6 1.6 -0.3 0.0 0.8 1.3 1.1 1.0 0.1 1.9 -0.2 -0.4 0.2 -0.2 -0.4 -0.1
Hand grip strength (right) 1.1 2.9 7.5 1.7 -2.7 0.0 1.1 1.2 1.3 0.7 2.1 -0.7 2.1 1.7 1.5 2.2 2.0 2.3
Townsend deprivation index at recruitment 1.3 1.9 4.7 1.5 0.1 0.0 2.0 1.8 1.7 2.2 1.6 0.8 1.3 0.3 0.6 1.1 1.0 1.8
Current tobacco smoking 1.2 2.0 4.7 1.4 -0.9 0.0 1.5 1.6 2.2 1.9 1.6 -0.3 1.4 0.9 1.0 1.2 1.6 1.6
Average weekly fortified wine intake 0.5 0.6 1.4 -0.1 0.0 0.0 -0.7 -0.6 -1.0 0.2 -0.9 0.3 -1.1 -1.0 -0.9 -0.7 -1.2 -0.9
Maternal smoking around birth 0.4 0.6 1.8 0.2 0.4 0.0 -0.2 1.3 0.3 1.3 0.6 -0.9 1.1 0.7 1.0 0.8 0.7 0.6
Fed-up feelings 0.9 1.7 7.0 1.7 -1.5 0.0 2.6 2.1 1.8 -0.3 1.1 1.1 0.3 -1.2 -0.9 0.0 0.3 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.5 0.3 -0.6 0.0 0.8 0.7 0.2 -0.8 0.0 0.6 -0.2 -1.2 -1.0 -0.4 -0.2 0.2
Relative age voice broke 0.2 0.3 0.7 0.2 -0.8 0.0 0.3 -0.6 0.4 0.1 0.6 -0.1 0.7 0.8 0.7 0.6 0.8 0.7
Taking other prescription medications 10.3 15.9 27.0 4.3 -4.7 0.0 5.0 3.1 4.8 1.7 5.0 -0.6 4.7 3.1 3.4 4.6 4.5 5.2
Age when periods started (menarche) 0.1 0.3 1.7 0.1 -1.1 0.0 -0.3 -0.4 -0.3 -1.3 0.2 0.7 0.3 0.3 0.1 -0.0 0.2 0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.7 -0.6 0.5 0.0 -0.8 -0.6 -0.8 0.3 -0.7 -0.3 -0.6 -0.4 -0.6 -0.4 -0.4 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 7.5 -1.6 2.7 0.0 -1.6 -2.2 -1.2 1.4 -1.8 0.4 -1.8 -0.8 -0.9 -1.6 -1.5 -1.8
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 4.1 -0.4 0.3 0.0 0.1 -0.2 -0.3 -2.0 -0.6 -0.1 -0.7 -1.5 -1.3 -1.2 -0.8 -0.8
Qualifications: CSEs or equivalent 0.2 0.3 1.1 0.8 -0.2 0.0 1.0 0.1 0.7 1.0 0.4 0.7 0.1 -0.3 -0.0 -0.2 -0.0 0.3
Serious illness, injury or assault to yourself 2.2 2.7 5.3 1.8 -1.4 0.0 1.6 1.0 2.0 -0.4 2.3 -1.1 2.2 1.2 1.2 2.1 1.9 2.2
High blood pressure 0.2 0.6 3.0 1.1 0.2 0.0 1.3 1.0 0.8 -0.5 0.6 1.7 0.3 -0.5 -0.1 -0.1 -0.0 0.5
Hayfever, allergic rhinitis or eczema 17.1 37.1 64.5 7.1 -5.6 0.0 8.0 5.4 7.5 4.2 7.4 -0.1 6.8 5.4 5.8 6.5 6.6 7.6
Multivitamins +/- minerals 1.1 1.5 2.5 1.2 -1.4 0.0 1.1 0.6 1.4 0.5 1.6 -0.5 1.5 1.2 1.1 1.5 1.6 1.5
Stomach or abdominal pain in last month 0.7 0.8 2.9 0.6 -0.6 0.0 1.1 1.7 0.6 0.9 1.1 1.4 1.0 0.1 0.1 0.6 0.8 1.2
Supplements: Glucosamine 0.1 0.2 1.0 0.3 -0.5 0.0 0.6 0.6 0.5 -0.1 0.1 1.0 -0.2 -0.1 -0.3 -0.2 0.1 0.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.4 -0.3 1.2 0.0 -0.2 -1.0 -0.3 0.2 -0.1 -0.7 -0.2 0.3 0.3 0.2 -0.0 -0.0
Medication: Atenolol 0.4 0.5 2.6 1.1 0.4 0.0 1.4 0.9 0.9 -0.1 0.3 1.6 0.1 -0.2 -0.0 -0.1 0.2 0.4
Medication: Levothyroxine sodium 1.8 3.1 9.2 3.0 -1.5 0.0 2.8 2.3 2.2 -0.4 2.0 0.1 1.7 0.7 1.2 1.7 1.2 1.9
Sitting height 0.2 1.2 3.5 -1.1 -0.5 0.0 -1.8 -1.9 -1.3 0.2 -0.7 -0.5 -0.9 -1.4 -1.7 -0.8 -0.8 -0.6
Chronic bronchitis/emphysema (father) 1.9 2.2 3.7 1.7 -0.9 0.0 1.7 0.1 1.9 0.9 1.9 -0.6 1.8 1.6 1.6 1.9 1.8 1.9
High blood pressure (mother) 0.1 0.1 0.4 0.2 -0.6 0.0 0.4 -0.3 0.4 -0.7 -0.0 -0.4 0.0 -0.3 -0.2 -0.0 0.3 -0.1
Body mass index (BMI) 0.3 1.4 3.4 0.2 0.6 0.0 -0.6 0.5 -0.5 1.3 -1.3 1.6 -1.6 -1.4 -1.2 -1.9 -1.4 -1.4
Impedance of leg (left) 0.3 1.4 3.3 1.4 -0.3 0.0 1.5 0.3 1.5 -0.2 1.3 -0.3 1.4 1.6 1.8 1.6 1.2 1.0
Leg predicted mass (left) 0.2 0.8 3.4 0.0 -1.4 0.0 -0.9 -0.2 -0.6 0.1 -0.5 0.7 -0.9 -1.8 -1.6 -1.1 -0.8 -0.4
Trunk fat mass 0.2 0.7 3.5 1.2 -0.3 0.0 0.2 0.9 0.5 0.8 -0.3 1.9 -0.7 -1.0 -0.5 -0.8 -0.8 -0.5
Waist circumference 0.5 1.8 4.8 -0.0 0.9 0.0 -0.6 -0.0 -0.7 0.4 -1.5 1.6 -1.8 -2.2 -1.7 -2.0 -1.9 -1.5
Number of incorrect matches in round 2.4 4.0 6.8 1.4 -2.4 0.0 1.2 1.3 1.9 1.1 2.2 -1.9 2.4 2.6 2.4 2.4 2.4 2.1
Past tobacco smoking 1.8 3.3 12.8 -1.8 1.2 0.0 -2.6 -2.0 -2.2 -3.6 -1.9 0.3 -1.4 -0.6 -0.5 -1.2 -2.0 -2.0
Alcohol usually taken with meals 2.0 3.2 7.0 -2.1 1.9 0.0 -2.1 -1.8 -2.6 -1.7 -2.3 0.8 -1.9 -0.8 -1.0 -1.7 -1.8 -2.2
Nervous feelings 0.8 1.5 7.1 -0.9 -1.2 0.0 -1.0 -1.5 -1.1 -2.7 -0.6 -1.7 -0.5 -1.5 -1.4 -0.4 -0.6 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 3.1 -0.7 0.1 0.0 -0.1 -0.3 -0.6 -1.8 -0.4 -0.0 -0.7 -1.1 -0.9 -0.6 -0.5 -0.2
Hearing difficulty/problems with background noise 1.2 1.9 4.6 -1.5 0.6 0.0 -2.0 0.3 -1.8 -0.0 -1.2 -2.0 -1.0 -2.1 -1.9 -1.1 -1.3 -1.0
Hair/balding pattern: Pattern 2 0.3 0.4 1.9 -0.4 0.0 0.0 0.3 -0.8 0.2 0.1 0.5 -1.4 0.6 0.1 0.0 0.7 0.8 0.8
Had menopause 1.1 1.4 3.6 1.1 -1.3 0.0 0.6 1.9 1.2 -0.0 1.1 -0.5 1.1 1.7 1.8 1.4 1.3 0.9
Had other major operations 0.1 0.1 0.8 0.2 -0.7 0.0 0.2 0.9 0.2 0.2 0.2 -0.4 0.3 0.2 0.2 0.3 0.4 0.2
Forced vital capacity (FVC) 0.7 2.6 8.0 -1.6 -2.8 0.0 -1.9 -1.2 -1.8 -2.6 -0.9 -1.3 -1.0 -2.0 -2.2 -1.1 -0.8 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.1 9.3 -2.4 2.9 0.0 -2.4 -3.0 -1.9 1.3 -2.4 0.1 -2.3 -1.1 -1.3 -2.0 -2.0 -2.4
Ever unenthusiastic/disinterested for a whole week 1.5 1.9 7.6 1.7 -1.0 0.0 2.8 1.0 2.1 1.7 1.5 0.4 1.1 0.4 0.4 0.7 1.3 1.5
Qualifications: None of the above 2.9 6.3 11.4 2.5 -2.1 0.0 2.8 2.4 3.4 2.0 2.9 0.9 2.7 2.7 2.8 2.6 2.8 2.7
Financial difficulties in last 2 years 1.0 1.3 4.5 0.9 -1.6 0.0 1.4 1.3 1.5 2.1 1.3 0.6 1.0 -0.2 -0.3 0.4 0.9 1.3
Mouth/teeth dental problems 0.2 0.3 0.9 -0.5 -0.4 0.0 -0.3 -0.1 -0.0 -0.3 0.6 -0.9 0.7 0.8 0.4 1.0 0.8 0.6
Heart attack 2.0 2.5 6.6 2.6 -0.9 0.0 2.4 0.3 2.4 1.5 1.6 1.2 1.4 1.3 1.5 1.5 1.4 1.7
Allergy 37.4 85.9 132.2 -10.0 8.6 0.0 -10.7 -8.3 -10.9 -6.2 -11.4 1.9 -10.9 -8.9 -9.3 -10.5 -10.7 -11.5
Pain all over the body in last month 0.9 1.0 4.3 1.4 -0.3 0.0 2.1 0.7 1.6 0.3 1.2 0.7 1.0 0.1 0.3 0.7 0.7 1.2
Diabetes (self-reported) 1.4 2.2 5.6 1.2 -0.7 0.0 0.9 2.4 1.2 1.3 1.6 -1.3 1.7 1.7 1.6 1.6 1.8 1.6
Hayfever/allergic rhinitis (self-reported) 14.8 19.6 36.3 5.4 -4.1 0.0 6.0 3.7 5.9 2.6 5.3 0.6 4.6 4.3 4.4 4.5 4.9 5.2
Medication: Ramipril 0.5 0.7 2.6 1.2 1.4 0.0 0.8 0.3 0.9 1.3 0.3 1.6 -0.1 0.4 0.5 -0.1 0.0 0.1
Medication: Simvastatin 0.7 1.0 4.1 0.7 -1.0 0.0 1.6 2.0 1.1 1.0 1.0 0.4 1.0 0.2 0.4 0.6 0.6 1.0
Fluid intelligence score 1.3 2.6 4.4 -1.8 2.1 0.0 -2.1 -2.1 -1.8 1.3 -1.7 -1.4 -1.6 -1.4 -1.5 -1.3 -1.6 -1.5
Illnesses of siblings 0.4 0.6 2.3 -0.7 0.1 0.0 -0.6 -1.4 -0.8 -1.5 -0.7 0.3 -0.7 -0.3 -0.5 -0.8 -0.8 -0.8
Neuroticism score 0.5 1.0 4.1 0.7 -2.0 0.0 1.2 0.4 0.7 -1.1 0.7 -0.2 0.3 -1.6 -1.5 0.0 0.4 1.0
Weight 0.2 1.1 3.6 0.4 -0.7 0.0 -0.6 0.2 -0.4 0.5 -0.9 1.4 -1.3 -1.9 -1.6 -1.6 -1.3 -0.9
Impedance of arm (right) 2.5 11.8 21.3 4.0 -2.9 0.0 4.6 2.2 4.4 -0.7 4.3 -0.2 4.0 3.1 3.7 4.3 3.5 4.2
Arm fat percentage (right) 0.2 1.0 4.1 2.0 -0.3 0.0 1.2 1.8 1.3 1.3 0.4 1.4 0.1 -0.3 0.2 -0.1 -0.1 0.3
Trunk fat-free mass 0.3 1.7 4.7 -0.7 -1.0 0.0 -1.9 -0.9 -1.5 -0.3 -1.1 -0.2 -1.4 -2.1 -2.2 -1.6 -1.2 -1.0
Hip circumference 0.8 3.3 8.4 0.2 0.7 0.0 -0.5 0.0 -0.7 1.3 -1.9 2.9 -2.5 -2.6 -2.3 -2.7 -2.3 -1.9
Time employed in main current job 1.2 1.4 6.1 -0.9 0.4 0.0 -1.7 -1.2 -1.4 -2.5 -1.3 -1.4 -0.8 0.1 0.0 -0.8 -0.8 -1.5
Alcohol intake versus 10 years previously 0.5 0.8 2.3 -0.8 0.5 0.0 -1.4 -0.2 -0.8 0.7 -0.7 -0.1 -0.8 -1.5 -1.5 -0.9 -0.8 -0.8
Father’s age at death 3.0 4.0 6.7 -2.2 1.7 0.0 -2.3 -0.8 -2.6 -2.3 -2.3 1.1 -2.0 -2.3 -2.3 -2.1 -2.0 -2.1
Worrier / anxious feelings 0.7 1.3 3.4 1.4 -1.8 0.0 1.5 0.7 1.4 -1.3 1.4 -0.4 1.0 -0.2 -0.1 0.9 1.0 1.6
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 4.6 0.9 -1.0 0.0 2.1 2.0 1.2 -0.4 1.0 0.7 0.7 -1.1 -0.6 0.0 0.5 1.2
Falls in the last year 1.7 2.3 7.9 -2.0 2.8 0.0 -1.4 -1.3 -1.5 -1.7 -1.7 0.6 -1.5 -1.0 -0.9 -1.2 -1.6 -1.7
Hair/balding pattern: Pattern 3 0.4 0.5 3.4 0.9 -0.8 0.0 0.6 1.8 0.7 0.6 0.5 -0.2 0.5 0.6 0.6 0.3 0.5 0.3
Number of live births 2.1 2.9 6.7 1.9 -1.5 0.0 2.2 -0.3 1.9 2.6 1.8 -0.1 1.6 1.7 1.7 1.7 2.1 2.0
Forced expiratory volume in 1-second (FEV1) 1.7 5.7 11.9 -2.8 -1.1 0.0 -3.0 -2.3 -3.0 -2.0 -2.4 -0.9 -2.4 -3.2 -3.5 -2.5 -2.2 -2.1
Pulse rate 0.7 1.2 3.3 0.9 0.9 0.0 0.9 1.8 0.8 1.8 1.0 -0.7 0.9 1.3 1.3 1.0 1.2 0.8
Happiness 0.8 1.0 2.6 1.1 -0.8 0.0 1.5 1.1 1.6 0.8 1.2 -0.6 0.9 -0.6 -0.4 0.4 1.1 1.3
Noisy workplace 0.3 0.3 1.5 0.5 0.5 0.0 1.2 0.6 0.8 0.1 -0.2 1.0 -0.6 0.2 0.4 -0.3 -0.2 -0.4
Qualifications: A levels/AS levels or equivalent 0.2 0.5 2.4 0.3 -0.6 0.0 0.3 -0.3 -0.0 -0.4 1.0 -1.6 0.9 0.1 0.1 1.1 0.6 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 2.7 -1.2 1.1 0.0 0.2 -1.3 -0.5 -1.6 -1.1 0.2 -1.4 -0.9 -0.8 -1.1 -1.2 -1.1
Mouth/teeth dental problems: Dentures 5.9 9.9 14.2 3.6 -2.0 0.0 3.0 2.9 3.6 3.3 3.7 -0.1 3.5 3.6 3.8 3.4 3.5 3.6
Asthma 72.6 143.1 219.0 11.4 -11.2 0.0 11.5 10.2 13.2 9.2 14.4 -4.4 14.6 12.7 12.6 14.2 14.8 14.7
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 3.6 -0.4 -1.9 0.0 -0.2 1.2 -0.0 -0.4 0.5 -0.4 0.5 0.0 -0.2 0.4 0.8 0.8
Medication: Cholesterol lowering 0.5 0.9 6.0 0.6 0.4 0.0 1.5 1.0 0.9 -0.0 -0.3 2.4 -0.6 -0.8 -0.4 -0.6 -0.8 -0.3
Depression (self-reported) 0.9 1.0 2.5 0.8 -0.5 0.0 1.6 1.6 1.1 -0.6 1.3 0.3 1.0 0.8 0.9 0.9 1.0 1.4
Medication: Lansoprazole 0.2 0.2 1.8 -0.2 -0.9 0.0 -0.4 1.3 -0.1 -0.6 0.2 -0.1 0.4 -0.1 -0.0 0.4 0.3 0.1
Prospective memory result 0.5 0.7 1.2 0.9 -0.3 0.0 0.9 0.8 1.1 -0.6 0.9 0.7 0.9 1.1 1.0 0.8 0.8 0.8
Lung cancer (father) 0.4 0.5 3.6 -0.7 -0.6 0.0 -1.3 -0.1 -0.7 0.4 -0.2 -1.9 0.2 0.3 0.3 0.3 -0.1 -0.2
Illnesses of mother 0.5 0.7 3.0 -0.9 0.9 0.0 -1.7 -1.3 -1.2 1.1 -0.2 0.4 -0.0 -0.1 -0.4 -0.1 -0.6 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.6 13.4 -2.8 -1.1 0.0 -2.5 -2.3 -2.7 -2.1 -2.4 -0.2 -2.5 -3.3 -3.7 -2.6 -2.2 -2.0
Pulse wave Arterial Stiffness index 0.6 0.7 3.6 0.8 -0.3 0.0 1.2 -0.6 0.9 1.9 0.3 1.8 -0.0 0.2 0.2 -0.0 0.0 0.2
Impedance of arm (left) 2.4 11.3 19.0 3.9 -3.0 0.0 4.4 2.3 4.3 -0.9 4.2 -0.1 4.0 3.1 3.7 4.3 3.4 4.0
Arm fat mass (right) 0.2 0.8 2.3 1.1 -0.1 0.0 0.0 1.0 0.2 1.1 -0.5 1.5 -0.9 -1.2 -0.8 -1.1 -1.0 -0.6
Trunk predicted mass 0.3 1.8 4.8 -0.7 -1.0 0.0 -1.9 -0.8 -1.5 -0.3 -1.2 -0.1 -1.4 -2.2 -2.2 -1.7 -1.3 -1.0
Standing height 0.1 1.0 7.8 0.5 -2.8 0.0 -0.2 -1.0 0.1 -1.6 0.7 -0.7 0.3 -1.1 -0.8 0.4 0.1 0.8
Length of working week for main job 0.2 0.2 1.6 0.2 -0.3 0.0 0.5 1.3 0.1 0.0 0.3 0.0 0.2 0.5 0.5 0.3 0.5 0.3
Exposure to tobacco smoke at home 0.6 0.7 2.4 1.1 -1.3 0.0 0.3 1.4 0.2 -1.5 0.7 0.6 0.7 -0.1 0.3 0.7 0.2 0.7
Breastfed as a baby 0.7 0.9 1.7 1.3 -1.1 0.0 1.0 0.7 1.1 0.3 0.9 0.7 0.8 1.1 1.1 0.7 1.3 0.9
Tense / ‘highly strung’ 0.7 1.2 3.5 -0.8 -0.0 0.0 -0.5 -1.2 -0.9 -1.9 -0.8 -0.4 -1.0 -1.9 -1.8 -1.0 -0.9 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 2.2 0.5 -0.7 0.0 1.5 -0.4 1.2 -0.6 1.0 -0.6 0.7 -0.7 -0.7 0.4 0.7 1.2
Hair/balding pattern: Pattern 4 0.5 1.2 2.7 1.6 0.4 0.0 1.3 0.5 1.6 1.4 1.0 0.9 0.5 1.6 1.5 0.7 0.8 0.6
Birth weight of first child 1.7 3.0 5.3 0.8 -1.5 0.0 1.9 1.5 1.8 2.1 2.0 -0.5 2.0 1.9 1.8 1.9 2.3 2.3
Peak expiratory flow (PEF) 0.3 0.7 2.8 0.1 -1.7 0.0 -0.4 1.2 -0.1 0.6 0.7 -1.4 0.6 -0.2 -0.4 0.7 0.9 1.0
Pulse wave reflection index 0.3 0.4 4.0 -0.8 -0.2 0.0 -0.2 -2.0 -0.2 0.1 -0.3 0.4 -0.4 -0.5 -0.4 -0.3 -0.7 -0.3
Ever highly irritable/argumentative for 2 days 0.6 0.7 4.3 0.5 -0.7 0.0 0.4 -0.4 0.7 1.0 0.9 -2.1 1.0 -0.1 -0.0 0.8 1.1 0.9
Loud music exposure frequency 0.9 1.0 5.9 1.2 -1.0 0.0 1.7 0.9 1.2 -2.4 0.0 1.0 -0.5 -0.5 -0.4 -0.4 -0.0 -0.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.7 0.8 -0.1 0.0 0.4 0.3 0.3 0.0 0.4 0.2 0.3 -0.2 -0.1 0.1 -0.0 0.4
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 5.0 -1.2 -0.4 0.0 -1.1 -0.0 -1.3 -2.2 -1.1 -0.3 -0.9 -0.8 -0.6 -0.8 -0.9 -1.0
Blood clot in the leg (DVT) 0.8 1.0 1.9 0.9 -0.4 0.0 1.4 1.1 1.4 0.2 1.2 0.8 1.0 1.2 1.2 1.1 0.8 1.1
Medication: Paracetamol 0.1 0.2 0.8 -0.1 -0.9 0.0 -0.2 0.7 -0.0 0.2 0.3 -0.6 0.2 -0.6 -0.6 0.2 0.4 0.3
Headache pain in last month 0.6 1.0 3.0 1.3 -1.2 0.0 1.7 1.1 1.3 -0.3 1.2 1.3 0.8 0.0 0.1 0.6 0.8 1.2
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 3.8 -1.3 0.2 0.0 -1.7 -1.7 -1.4 -0.2 -0.5 -1.9 0.0 0.3 -0.2 -0.0 0.1 -0.3
Glaucoma (self-reported) 0.2 0.2 2.1 0.1 -0.6 0.0 0.5 0.1 0.5 0.2 -0.0 1.5 -0.1 0.1 0.0 -0.1 -0.2 0.0
Gout (self-reported) 5.8 7.9 13.5 -3.3 3.7 0.0 -3.1 -1.7 -3.4 -1.3 -3.1 0.7 -3.0 -3.0 -3.1 -3.0 -3.4 -3.2
Hypothyroidism/myxoedema (self-reported) 2.1 4.1 11.1 3.3 -2.2 0.0 2.8 2.7 2.6 -0.6 2.3 -0.1 2.3 0.7 1.3 1.9 1.5 2.2
Medication: Amlodipine 0.2 0.3 1.6 -0.6 0.7 0.0 0.2 -0.0 -0.4 0.9 -0.5 1.3 -0.5 -0.5 -0.6 -0.6 -0.5 -0.2
Medication: Ventolin 100micrograms inhaler 29.7 38.1 58.8 6.0 -5.8 0.0 5.8 5.9 6.9 4.0 7.3 -2.3 7.3 6.8 6.8 7.2 7.7 7.3
Birth weight 0.4 0.9 5.7 1.0 -0.4 0.0 0.4 -0.5 1.0 2.4 1.0 -0.9 0.8 0.5 0.4 0.9 0.9 1.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.4 0.5 -1.0 0.0 0.7 -0.2 0.6 0.2 0.9 -0.8 0.9 0.5 0.8 1.2 0.8 1.1
High blood pressure (siblings) 0.1 0.2 0.6 -0.5 -0.7 0.0 -0.3 0.2 -0.2 0.8 0.2 -0.6 0.4 -0.4 -0.4 0.3 0.5 0.4
Forced vital capacity (FVC), Best measure 0.6 2.0 8.6 -1.3 -2.9 0.0 -1.3 -1.1 -1.3 -2.3 -0.7 -0.8 -0.8 -1.8 -2.0 -0.9 -0.5 -0.4
Body fat percentage 0.2 0.6 2.7 1.4 -0.1 0.0 0.5 1.4 0.8 1.0 -0.2 1.6 -0.4 -0.5 -0.0 -0.5 -0.6 -0.4
Leg fat percentage (right) 0.3 1.0 3.4 1.2 0.6 0.0 0.2 1.8 0.4 1.0 -0.7 1.8 -0.9 -0.9 -0.4 -1.2 -0.9 -0.9
Arm fat-free mass (right) 0.8 4.2 8.6 -1.6 0.1 0.0 -2.7 -1.3 -2.4 -0.0 -2.2 0.5 -2.4 -2.9 -2.9 -2.7 -2.3 -2.2
Exposure to tobacco smoke outside home 3.7 5.0 8.6 2.5 -2.9 0.0 2.5 2.7 2.0 -2.0 2.8 0.2 2.7 1.4 1.7 2.2 2.2 2.8
Comparative body size at age 10 1.0 2.9 6.9 -1.4 2.6 0.0 -1.7 -0.9 -1.7 2.0 -1.8 -0.6 -1.8 -1.9 -1.8 -1.9 -1.8 -1.8
Number of full brothers 1.3 1.6 5.4 1.0 0.2 0.0 0.9 0.7 1.1 2.3 1.3 -0.6 1.3 1.9 1.9 1.4 1.3 1.2
Worry too long after embarrassment 0.3 0.5 2.5 -0.4 -1.3 0.0 -0.4 0.3 -0.5 -0.1 0.5 -1.6 0.7 -0.7 -0.7 0.5 0.5 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.5 5.0 1.8 -2.2 0.0 2.2 1.5 2.1 -0.1 2.0 -1.3 1.8 0.6 0.7 1.4 1.8 2.0
Wheeze or whistling in the chest in last year 20.8 37.1 54.9 6.8 -5.5 0.0 7.3 6.2 7.2 4.3 7.4 0.0 6.9 5.7 6.1 6.7 6.8 7.4
Number of children fathered 0.4 0.5 2.2 0.3 0.2 0.0 0.9 0.7 0.6 1.5 0.6 0.6 0.4 0.8 0.5 0.4 0.7 0.7
Reason for reducing amount of alcohol drunk: Health precaution 2.6 3.0 7.4 -1.9 0.8 0.0 -2.7 -1.5 -2.2 -2.4 -1.8 -1.4 -1.4 -1.7 -1.9 -1.2 -1.7 -1.7
Age at first live birth 0.2 0.4 3.2 -0.2 -0.4 0.0 -0.2 -1.1 -0.6 -1.8 -0.1 0.1 0.1 0.5 0.7 0.4 -0.1 0.0
Pulse wave peak to peak time 0.5 0.6 3.5 -0.7 0.1 0.0 -1.2 0.4 -0.8 -1.9 -0.2 -1.8 0.2 -0.1 -0.1 0.2 0.1 -0.0
Health satisfaction 0.8 1.0 3.9 1.1 -1.5 0.0 2.0 1.5 1.4 0.7 0.9 0.7 0.4 -0.2 -0.2 -0.1 0.9 0.8
Shortness of breath walking on level ground 2.2 2.6 8.4 2.1 -1.8 0.0 2.9 2.2 2.3 0.8 1.4 0.8 1.0 1.3 1.5 1.0 1.3 1.4
Qualifications: College or University degree 2.4 7.5 13.9 -3.7 3.4 0.0 -3.4 -1.6 -3.7 -3.1 -3.0 -1.8 -2.6 -2.0 -2.3 -2.1 -2.7 -2.8
Eye problems/disorders: None of the above 2.4 2.8 5.6 2.1 -0.0 0.0 1.1 1.0 1.6 1.9 1.9 -0.8 1.9 2.2 2.4 2.1 2.0 1.7
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.7 0.0 0.2 0.0 0.4 -0.2 0.2 0.9 0.1 0.5 -0.1 -0.2 -0.0 -0.2 0.1 0.1
Emphysema/chronic bronchitis 6.5 7.3 13.2 2.3 -3.4 0.0 2.0 2.0 2.6 1.3 3.4 -2.0 3.6 2.4 2.7 3.5 3.3 3.4
Medication for pain relief, constipation, heartburn 0.4 0.6 4.2 -0.5 1.3 0.0 -1.0 -2.1 -0.8 -0.6 -0.6 -0.1 -0.4 0.5 0.3 -0.3 -0.5 -0.7
Neck or shoulder pain in last month 0.5 0.8 3.4 0.7 0.1 0.0 1.3 1.8 1.2 -0.5 0.2 1.9 -0.4 -0.6 -0.3 -0.3 -0.5 0.1
Medication: Blood pressure 0.3 0.5 1.9 1.3 0.1 0.0 1.1 1.2 1.0 -0.1 0.5 1.4 0.1 0.1 0.6 0.2 -0.0 0.2
Angina (self-reported) 0.3 0.5 1.8 0.8 1.4 0.0 0.5 0.4 0.2 -0.3 -0.6 1.3 -0.6 0.1 0.4 -0.6 -0.6 -0.7
Migraine (self-reported) 0.2 0.3 1.5 0.5 0.1 0.0 1.1 0.7 0.5 -0.5 0.3 1.2 -0.1 -0.1 0.1 0.2 0.1 0.3
Medication: Ibuprofen 0.3 0.4 1.4 -1.0 -1.0 0.0 -1.2 0.8 -1.0 -0.2 -0.3 0.1 -0.2 -0.3 -0.5 -0.2 0.1 -0.1
Medication: Allopurinol 2.5 3.3 6.8 -2.6 2.4 0.0 -2.4 0.0 -2.5 -0.5 -1.9 -0.5 -1.8 -1.9 -2.0 -1.8 -2.1 -2.0
Medication: Omeprazole 0.1 0.2 1.3 0.1 0.3 0.0 0.5 1.1 0.2 -0.4 0.1 -0.2 0.1 -0.6 -0.4 -0.1 -0.2 0.0
Medication: Seretide 50 evohaler 8.1 9.3 13.5 3.1 -3.7 0.0 3.4 3.7 3.2 3.1 3.5 -0.5 3.6 2.4 2.4 3.1 3.3 3.6
Mean time to correctly identify matches 0.7 1.2 3.5 1.0 -1.3 0.0 1.9 -0.2 1.1 1.6 1.4 1.0 1.1 0.3 0.2 0.8 1.2 1.6
Heart disease (mother) 4.1 5.0 9.1 2.7 -1.3 0.0 2.8 3.0 2.8 0.1 2.5 -0.1 2.3 2.3 2.6 2.5 2.4 2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 8.5 0.8 -0.1 0.0 1.0 0.8 1.3 2.9 1.3 -0.1 1.3 1.7 1.4 1.4 1.8 1.4
Whole body fat mass 0.2 0.7 2.3 0.9 -0.1 0.0 -0.2 1.0 0.2 1.0 -0.5 1.5 -0.8 -1.1 -0.6 -1.0 -0.9 -0.7
Leg fat mass (right) 0.2 0.9 2.3 0.8 0.0 0.0 -0.4 1.2 -0.1 0.7 -0.8 1.5 -1.1 -1.3 -0.8 -1.4 -1.1 -1.0
Arm predicted mass (right) 1.0 5.0 9.7 -1.8 0.2 0.0 -2.9 -1.7 -2.6 0.0 -2.5 0.5 -2.7 -3.1 -3.1 -2.9 -2.5 -2.4
Pulse rate, automated reading 1.8 5.7 12.1 1.9 -0.7 0.0 1.7 2.5 1.9 2.9 2.4 -1.8 2.7 3.4 3.5 2.8 2.7 2.3
Alcohol intake frequency. 3.6 8.3 14.1 3.5 -2.1 0.0 2.8 1.9 3.5 3.8 3.5 -0.4 3.3 2.8 2.8 3.1 3.2 3.4
Comparative height size at age 10 0.2 1.2 4.0 1.4 -2.0 0.0 1.2 -1.3 1.0 -0.0 1.3 -0.8 0.9 0.1 0.7 1.4 0.7 1.3
Number of full sisters 1.6 2.0 3.6 1.3 -1.1 0.0 1.7 0.6 1.9 1.6 1.6 1.5 1.5 1.3 1.1 1.1 1.7 1.6
Suffer from ‘nerves’ 0.9 1.3 7.1 -1.2 -0.7 0.0 -0.7 -0.6 -1.1 -2.7 -1.1 -0.4 -1.3 -1.4 -1.2 -1.0 -0.9 -1.0
Overall health rating 0.7 1.4 6.7 1.6 -0.9 0.0 2.6 1.5 1.7 -0.8 1.3 1.1 0.8 -0.5 -0.0 0.4 0.6 1.2
Chest pain or discomfort 7.2 10.4 17.8 3.5 -3.4 0.0 3.7 4.2 3.8 1.5 3.9 -0.9 3.7 2.2 2.6 3.4 3.8 4.0
Had major operations 1.0 1.2 2.1 0.5 -1.4 0.0 0.3 1.2 0.8 1.3 1.2 -1.4 1.2 0.9 0.7 1.4 1.2 1.3
Age at last live birth 0.2 0.3 3.1 0.2 -0.7 0.0 0.4 -0.1 -0.1 -1.8 0.2 0.2 0.2 0.4 0.6 0.5 0.2 0.4
Family relationship satisfaction 3.4 4.2 7.4 2.2 -2.0 0.0 2.7 2.3 2.5 1.7 2.6 0.3 2.3 1.4 1.5 1.9 2.3 2.7
Leg pain on walking 0.2 0.3 1.3 0.6 -0.6 0.0 1.1 0.5 1.1 -0.1 0.3 -0.5 -0.1 -0.0 0.1 -0.1 0.2 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.2 1.0 -0.7 0.0 0.9 -0.6 0.7 0.7 0.7 1.1 0.5 0.2 0.1 0.4 0.3 0.7
Commuting to job workplace: Car/motor vehicle 0.2 0.2 2.1 0.2 -0.4 0.0 0.3 -0.4 0.7 1.5 -0.0 0.6 -0.1 0.4 0.3 -0.1 0.0 -0.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 1.2 -0.1 0.2 0.0 -0.7 1.1 -0.5 0.8 -0.2 -0.9 0.1 0.5 0.6 0.3 0.1 -0.1
Medication: Aspirin 0.5 0.6 2.1 1.2 -0.6 0.0 1.4 0.6 1.0 0.6 0.8 0.1 0.8 0.4 0.6 0.8 0.7 0.9
Supplements: Vitamin C 10.9 12.9 19.3 4.0 -4.1 0.0 2.9 3.2 4.1 0.9 4.4 -1.3 4.4 3.7 3.9 4.3 4.3 4.2
Knee pain experienced in last month 1.0 1.5 8.5 -0.2 0.3 0.0 0.6 0.9 0.2 -2.9 -0.6 2.3 -1.2 -1.3 -0.9 -1.1 -1.1 -0.7
Hypertension (Self-reported) 0.4 1.0 4.6 1.5 -0.4 0.0 1.7 1.0 1.3 0.2 1.0 2.1 0.6 -0.4 0.0 0.1 0.4 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.4 0.4 -0.0 0.0 0.3 1.2 0.2 -0.0 0.0 0.2 -0.0 -1.2 -0.8 0.0 -0.4 0.0
Illnesses of father: Heart disease 1.5 2.1 3.8 1.6 -0.3 0.0 1.7 1.9 1.7 1.9 1.7 -0.4 1.6 1.1 1.4 1.8 1.3 1.7
Illnesses of siblings: Diabetes 0.3 0.4 2.4 1.2 1.0 0.0 0.8 1.6 0.6 0.4 0.1 -0.4 -0.1 -0.1 0.3 -0.2 0.0 -0.0
Smoking status: Previous 0.7 1.0 5.9 0.8 -0.4 0.0 1.7 1.2 1.0 2.4 0.7 0.8 0.3 -0.2 -0.4 0.1 0.8 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.7 1.6 -1.2 0.0 1.4 -0.7 1.5 1.5 1.4 0.8 1.1 0.3 0.4 1.0 0.9 1.6
Whole body fat-free mass 0.3 1.8 4.9 -0.6 -0.9 0.0 -1.8 -1.0 -1.4 -0.2 -1.2 0.2 -1.5 -2.2 -2.1 -1.7 -1.4 -1.1
Leg fat-free mass (right) 0.3 1.7 5.1 -0.6 -1.1 0.0 -1.5 -1.1 -1.2 -0.1 -1.1 0.6 -1.4 -2.2 -2.1 -1.6 -1.4 -0.9
Arm fat percentage (left) 0.2 0.9 3.7 1.9 -0.4 0.0 1.1 1.8 1.3 1.1 0.4 1.4 0.1 -0.3 0.2 -0.1 -0.1 0.2
Average weekly red wine intake 4.7 6.9 12.7 -2.7 2.0 0.0 -3.2 -1.5 -3.6 -2.0 -3.3 -0.6 -2.8 -2.8 -2.7 -2.8 -3.2 -3.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.4 0.0 0.3 0.0 0.1 0.6 0.7 1.2 0.7 -0.4 1.1 1.2 1.1 0.9 1.0 0.7
Mood swings 0.8 1.4 4.2 1.3 -1.8 0.0 2.1 1.3 1.3 -1.5 1.1 1.3 0.6 -0.9 -0.7 0.2 0.4 1.2
Loneliness, isolation 0.6 0.8 3.0 0.6 -1.5 0.0 1.7 0.7 1.2 -0.9 1.1 0.2 0.7 -0.5 -0.4 0.3 0.6 1.1
Long-standing illness, disability or infirmity 2.6 4.0 6.2 2.5 -1.3 0.0 2.1 2.0 2.4 1.3 2.4 -1.1 2.4 1.9 2.2 2.5 2.1 2.3
Ever had bowel cancer screening 3.1 3.6 6.4 -1.9 2.0 0.0 -0.6 -0.0 -1.5 -1.2 -2.3 2.0 -2.5 -2.4 -2.2 -2.4 -2.4 -2.2
Diabetes diagnosed by doctor 1.7 2.8 7.1 1.6 -1.2 0.0 1.3 2.7 1.7 1.1 1.9 -1.4 1.9 1.6 1.7 1.8 2.0 1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 4.6 -0.5 -0.6 0.0 -0.6 0.0 -0.5 0.1 0.3 -2.1 0.5 1.1 0.9 0.9 0.7 0.3
Friendships satisfaction 2.6 3.2 6.0 2.1 -1.7 0.0 2.1 1.8 2.0 1.3 2.3 -0.4 2.3 1.3 1.2 1.8 2.1 2.5
Qualifications: nursing, teaching 1.1 1.8 3.7 -1.2 1.9 0.0 -1.5 -1.1 -1.7 -0.4 -1.4 -1.1 -1.4 -1.4 -1.4 -1.2 -1.5 -1.4
Commuting to job workplace: Walk 0.1 0.1 0.4 0.1 0.1 0.0 -0.3 0.6 -0.1 -0.4 0.1 0.0 -0.0 0.1 0.2 0.4 0.2 -0.0
Eye problems/disorders: Cataract 0.7 0.8 1.7 -0.5 0.7 0.0 0.1 -0.5 -0.1 0.6 -1.1 1.1 -1.3 -1.0 -1.1 -1.3 -1.3 -1.2
Mouth/teeth dental problems: Mouth ulcers 7.2 11.4 23.0 -1.9 3.3 0.0 -0.9 -2.3 -2.6 -1.0 -3.8 3.2 -4.5 -4.5 -4.3 -4.8 -4.4 -3.9
Medication for cholesterol 0.1 0.1 0.4 0.0 -0.2 0.0 -0.2 0.2 -0.2 -0.2 -0.5 0.0 -0.6 -0.3 -0.3 -0.4 -0.4 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.3 2.7 5.6 2.1 -1.5 0.0 2.0 1.5 2.4 0.6 2.0 0.0 1.8 1.4 1.5 1.8 1.8 2.0
Back pain experienced in last month 0.4 0.6 1.4 -0.7 0.8 0.0 0.3 1.1 -0.0 0.4 -0.7 1.1 -0.8 -1.2 -1.0 -0.9 -0.8 -0.5
Mineral and other dietary supplements 0.4 0.5 4.1 -0.8 0.1 0.0 -0.4 -1.3 -0.5 2.0 -0.3 -0.9 0.1 0.3 0.1 -0.1 -0.1 -0.0
Breast cancer (self-reported) 0.3 0.4 2.2 0.7 0.9 0.0 1.0 0.7 0.8 -0.5 0.2 1.5 0.0 -0.0 0.1 -0.2 -0.0 0.0
Asthma (self-reported) 74.5 148.4 228.0 11.5 -11.5 0.0 11.7 10.3 13.3 9.3 14.7 -4.7 14.9 12.9 12.8 14.5 15.1 15.0
Osteoporosis (self-reported) 0.4 0.5 3.9 -0.6 0.4 0.0 -0.6 -0.7 -0.6 -2.0 -0.4 0.3 -0.3 -0.6 -0.6 -0.3 -0.5 -0.5
Osteoarthritis (self-reported) 0.4 0.5 1.1 -1.0 0.5 0.0 -0.7 1.0 -0.5 -0.4 -0.8 -0.8 -1.0 0.3 0.3 -0.4 -0.6 -1.0
Medication: Aspirin 0.5 0.7 1.8 1.1 -0.7 0.0 1.4 0.3 1.1 0.8 0.9 -0.0 0.9 0.7 0.8 1.0 0.8 1.0
Medication: Gliclazide 0.7 0.8 4.6 -0.3 1.0 0.0 -0.8 -0.7 0.1 2.0 0.2 -2.1 0.5 0.5 0.5 0.5 0.2 0.2
Illnesses of father: None of the above (group 1) 0.8 1.0 1.9 -1.2 0.5 0.0 -1.0 -0.6 -1.1 -0.7 -1.2 0.9 -1.3 -0.9 -1.0 -1.3 -1.4 -1.2
Smoking status: Current 1.2 1.9 4.2 1.2 -0.9 0.0 1.4 1.4 2.0 2.1 1.6 -0.6 1.6 0.9 0.9 1.3 1.7 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.9 14.6 24.8 -4.5 1.2 0.0 -5.0 -4.2 -4.9 -4.9 -4.4 -0.1 -4.0 -3.3 -3.5 -3.6 -4.0 -4.3
Whole body water mass 0.3 1.9 5.2 -0.7 -0.9 0.0 -1.9 -0.9 -1.6 -0.3 -1.3 0.2 -1.5 -2.3 -2.2 -1.8 -1.4 -1.1
Leg predicted mass (right) 0.3 1.8 5.2 -0.7 -1.0 0.0 -1.6 -1.2 -1.3 -0.2 -1.2 0.6 -1.4 -2.3 -2.1 -1.7 -1.4 -1.0
Arm fat mass (left) 0.2 0.8 2.5 1.1 -0.2 0.0 0.1 1.1 0.3 1.0 -0.5 1.6 -0.9 -1.3 -0.8 -1.1 -1.0 -0.6
Number of self-reported non-cancer illnesses 9.2 16.0 28.2 4.4 -3.9 0.0 5.3 4.1 5.3 2.2 4.8 0.6 4.5 3.3 3.6 4.2 4.4 4.9
Average weekly champagne plus white wine intake 0.6 0.8 1.9 -0.9 1.4 0.0 -1.0 -1.1 -1.2 -1.3 -1.0 0.4 -0.8 0.0 -0.2 -0.6 -0.7 -0.9
Miserableness 4.6 7.9 18.7 3.2 -4.3 0.0 4.3 3.9 3.7 -0.5 3.2 0.1 2.6 0.8 1.1 2.3 2.8 3.3
Guilty feelings 0.7 1.1 3.6 0.5 -1.8 0.0 0.3 0.4 0.4 0.2 1.2 -1.9 1.3 0.3 0.4 1.4 1.1 1.5
Wears glasses or contact lenses 5.9 6.8 14.0 -1.9 1.5 0.0 -1.7 -1.2 -2.5 -3.7 -3.1 1.7 -3.4 -3.1 -2.8 -3.3 -3.2 -3.1
Ever taken oral contraceptive pill 0.3 0.4 2.5 -0.2 0.0 0.0 0.5 -1.6 0.1 1.2 -0.1 0.8 -0.3 -0.3 -0.4 -0.5 -0.0 0.1
Hearing aid user 0.9 1.1 2.2 -1.5 1.3 0.0 -1.4 -0.8 -1.2 0.2 -1.3 -0.4 -1.1 -0.7 -0.8 -1.1 -0.8 -1.3
Mother’s age at death 1.5 1.9 4.8 -1.7 0.2 0.0 -2.1 -0.5 -2.2 -1.8 -1.3 -1.0 -1.0 -1.4 -1.5 -1.1 -1.1 -1.2
Financial situation satisfaction 1.8 2.2 7.4 1.5 -2.7 0.0 2.2 1.6 1.8 0.8 1.7 -0.2 1.4 0.6 0.7 0.9 1.7 1.5
Tinnitus: Yes, now most or all of the time 0.2 0.3 1.2 0.5 -0.3 0.0 0.2 1.1 0.6 -0.2 0.6 0.1 0.5 0.5 0.5 0.7 0.4 0.4
Commuting to job workplace: Public transport 1.2 1.4 5.5 -1.1 0.2 0.0 -1.0 -0.3 -1.6 -2.3 -1.1 0.1 -1.1 -1.6 -1.5 -1.2 -1.2 -0.9
Eye problems/disorders: Glaucoma 0.2 0.2 3.0 -0.1 -0.2 0.0 0.2 0.3 -0.0 0.1 -0.1 1.7 -0.2 0.0 -0.0 -0.2 -0.4 -0.1
Medication: Blood pressure 0.2 0.4 1.8 0.5 0.6 0.0 1.0 0.4 0.5 1.2 0.5 1.3 0.4 -0.1 -0.1 -0.0 0.3 0.7
Pain type(s) experienced in last month: Hip pain 1.0 1.2 2.1 -1.5 0.7 0.0 -1.0 -0.6 -1.4 0.1 -1.5 -0.2 -1.4 -1.2 -1.4 -1.4 -1.1 -1.3
Supplements: Fish oil (including cod liver oil) 1.2 1.6 4.2 1.7 -0.3 0.0 1.3 2.1 1.4 -1.6 1.3 0.4 1.1 1.1 1.4 1.3 1.1 1.0
High cholesterol (Self-reported) 1.2 2.1 17.7 1.6 0.5 0.0 2.3 0.3 1.5 1.1 0.1 4.2 -0.3 -0.8 -0.4 -0.6 -0.7 0.2
Medication: Bendroflumethiazide 0.4 0.7 2.8 0.7 1.7 0.0 0.7 1.4 0.7 1.6 0.3 0.1 0.0 0.5 0.6 0.2 0.4 0.2
Medication: Paracetamol 0.4 0.6 2.0 -1.1 0.2 0.0 -1.3 0.1 -1.2 0.1 -0.6 -0.1 -0.7 -1.3 -1.4 -0.6 -0.4 -0.6
Medication: Lisinopril 2.2 2.8 4.8 -1.7 1.5 0.0 -1.7 -1.5 -1.9 -1.5 -2.0 -0.1 -2.0 -1.7 -1.6 -1.9 -2.0 -2.2
Medication: Atorvastatin 0.6 0.7 1.3 0.0 0.9 0.0 -0.9 -1.0 -0.4 -0.8 -0.9 0.8 -1.1 -0.8 -0.8 -1.0 -1.1 -1.1
Illnesses of father: High blood pressure 1.0 1.2 2.6 -0.8 0.6 0.0 -1.4 -0.5 -1.2 -0.8 -1.3 -0.3 -1.2 -1.4 -1.6 -1.5 -0.9 -1.4
Alcohol drinker status: Never 0.9 1.1 3.5 1.9 -0.8 0.0 1.1 0.7 1.4 0.6 1.4 -0.4 1.2 0.3 0.6 1.2 0.7 1.3
Ever smoked 2.6 4.5 11.2 2.1 -1.6 0.0 2.9 2.4 2.8 3.3 2.3 -0.5 1.9 1.1 1.1 1.7 2.5 2.5
Basal metabolic rate 0.3 1.4 4.5 -0.3 -0.9 0.0 -1.4 -0.6 -1.1 0.1 -1.1 0.5 -1.4 -2.1 -2.0 -1.6 -1.3 -1.0
Leg fat percentage (left) 0.4 1.4 3.7 0.6 1.0 0.0 -0.3 1.0 -0.2 1.0 -1.3 1.9 -1.5 -1.3 -0.9 -1.7 -1.5 -1.6
Arm fat-free mass (left) 0.5 2.7 6.0 -0.9 -0.2 0.0 -2.0 -1.0 -1.8 0.4 -1.8 0.8 -2.0 -2.4 -2.4 -2.3 -1.8 -1.7
Number of operations (self-reported) 0.6 0.9 3.3 0.8 -0.8 0.0 1.3 1.8 1.1 1.5 0.7 0.8 0.5 0.2 0.2 0.5 0.8 0.9
Average weekly beer plus cider intake 0.7 1.0 2.1 -0.6 -0.2 0.0 0.2 -1.0 -0.6 -1.5 -1.1 0.7 -1.3 -1.4 -1.4 -1.1 -1.2 -1.0
Irritability 0.9 1.6 7.3 -1.1 0.2 0.0 -1.0 0.6 -1.2 -0.2 -1.0 -0.7 -1.0 -2.5 -2.7 -1.5 -0.9 -0.8
Risk taking 0.3 0.4 2.8 -0.7 -0.5 0.0 -0.1 0.2 -0.6 -1.7 -0.4 -0.4 -0.3 -0.9 -0.8 -0.5 -0.6 -0.3
Ever had prostate specific antigen (PSA) test 0.3 0.3 2.2 0.3 -0.1 0.0 0.7 -0.0 0.8 0.9 0.1 1.5 -0.2 0.0 -0.1 -0.0 0.2 0.3
Fractured/broken bones in last 5 years 0.4 0.6 3.4 -1.4 -0.3 0.0 -0.8 -0.5 -0.8 -1.2 -0.3 -1.8 0.2 0.0 -0.3 0.2 0.1 -0.2
Age started oral contraceptive pill 1.6 1.9 3.3 -1.6 1.1 0.0 -1.1 -1.6 -1.3 -0.7 -1.8 0.8 -1.8 -1.2 -1.3 -1.6 -1.8 -1.7
Diastolic blood pressure, automated reading 0.3 1.1 5.5 -0.5 0.9 0.0 0.1 -0.5 -0.6 -0.5 -0.8 2.4 -1.2 -1.3 -1.1 -1.3 -1.2 -0.7
Ever depressed for a whole week 5.0 6.1 14.7 3.0 -2.1 0.0 3.8 2.5 3.5 2.9 2.9 0.5 2.4 1.2 1.3 2.1 2.5 3.0
Unable to work because of sickness or disability 0.2 0.2 1.3 0.3 -0.4 0.0 0.2 0.4 0.0 -1.1 0.3 -1.0 0.4 -0.4 -0.2 0.3 0.1 0.4
Commuting to job workplace: Cycle 0.5 0.6 1.6 -0.7 1.2 0.0 -0.8 0.6 -1.0 -0.8 -0.6 0.9 -0.5 -1.0 -0.9 -0.7 -0.7 -0.4
Myopia 9.1 13.3 24.2 4.9 -3.2 0.0 4.0 2.8 4.6 1.7 4.3 0.2 4.2 4.0 4.2 4.0 4.0 4.1
Vascular/heart problems diagnosed by doctor 0.2 0.7 3.1 -1.3 -0.0 0.0 -1.5 -0.8 -1.1 0.2 -0.7 -1.8 -0.3 0.4 0.0 0.0 -0.1 -0.7
Cholesterol lowering medication 0.6 0.9 2.8 0.9 -0.8 0.0 0.5 1.0 0.8 1.7 1.1 -0.7 1.3 0.8 0.8 0.8 0.9 1.0
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 3.3 0.8 -0.1 0.0 1.0 1.8 0.7 0.2 0.6 0.0 0.6 -0.2 0.1 0.3 0.3 0.5
Pain experienced in last month 0.9 1.4 6.7 0.3 -0.9 0.0 -0.8 -0.9 -0.2 1.3 0.6 -2.6 1.3 1.8 1.5 1.3 1.1 0.5
Supplements: Calcium 0.5 0.5 1.4 -1.1 -0.9 0.0 -1.2 -0.0 -0.8 -0.9 -0.5 -1.0 -0.3 -0.6 -1.0 -0.4 -0.1 -0.5
Basal cell carcinoma (self-reported) 4.2 4.9 9.2 2.1 -2.0 0.0 2.6 1.6 2.7 1.0 2.9 -0.7 2.6 2.2 2.3 2.7 2.5 3.0
Heart attack/myocardial infarction (self-reported) 2.3 2.9 7.0 2.6 -1.1 0.0 2.5 0.3 2.4 1.8 1.8 1.0 1.7 1.4 1.6 1.7 1.6 1.9
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 2.2 0.9 -0.6 0.0 1.5 1.0 1.5 0.3 1.4 0.6 1.2 1.4 1.4 1.3 1.0 1.3
Heart disease (siblings) 0.4 0.5 1.9 1.1 0.7 0.0 1.0 0.8 1.1 1.4 0.4 0.5 0.1 -0.0 0.1 0.1 0.2 0.3
Alcohol drinker status: Previous 0.6 0.7 2.4 0.3 -0.4 0.0 0.1 -0.5 0.7 1.6 0.9 -0.5 1.2 1.1 0.9 1.0 1.1 1.0
Pack years of smoking 0.3 0.5 1.6 0.6 -1.2 0.0 -0.1 -1.0 0.7 -0.6 0.4 0.2 0.5 0.9 1.0 0.7 0.8 0.4
Impedance of whole body 1.3 6.5 11.6 2.9 -1.8 0.0 3.4 1.6 3.3 -0.4 3.1 0.0 3.0 2.6 3.1 3.3 2.6 2.9
Leg fat mass (left) 0.3 1.2 2.9 0.5 0.3 0.0 -0.7 0.8 -0.4 0.8 -1.2 1.6 -1.4 -1.5 -1.1 -1.7 -1.4 -1.4
Arm predicted mass (left) 0.5 2.6 5.6 -1.0 -0.2 0.0 -2.1 -1.0 -1.8 0.4 -1.8 0.4 -2.0 -2.4 -2.4 -2.2 -1.8 -1.7