TWAS hub - IKZF3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0412	0.0158	3.1e-08	0.031	0.025	0.021	0.025	0.023	1.8e-10	1.5e-08	1.9e-07	1.7e-08	4.3e-08
2	TCGA	Stomach Adenocarcinoma	0.0350	0.0230	4.2e-03	0.007	0.020	0.002	NA	0.004	9.9e-02	1.3e-02	2.1e-01	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Respiratory disease	86.3	192.1	228.0	-15.1	-12.5
Asthma (self-reported)	83.1	165.5	198.8	-14.1	-11.5
Blood White Count	82.5	611.6	846.8	-29.1	-19.4
Asthma	81.2	160.2	190.4	-13.8	-11.4
Allergy	45.7	105.1	108.2	10.4	10.1
Medication: Ventolin 100micrograms inhaler	31.9	40.9	45.3	-6.7	-6.0
Wheeze or whistling in the chest in last year	29.1	51.8	57.2	-7.6	-6.8
Irritable Bowel Disease (IBD)	23.6	56.3	80.8	9.0	5.6
Hayfever, allergic rhinitis or eczema	22.8	49.4	54.0	-6.7	-7.3
Primary Biliary Cirrhosis	22.6	32.2	36.5	5.3	6.0
Hayfever/allergic rhinitis (self-reported)	20.1	26.7	33.0	-4.5	-5.7
Allergy or Eczema	20.0	52.6	58.1	-6.9	-7.6
HDL Cholesterol	18.9	31.5	33.0	5.7	5.5
Crohns Disease (2017)	17.1	37.5	51.1	7.2	4.9
Ulcerative Colitis (UC)	16.9	31.7	47.2	6.9	4.0
Ulcerative Colitis	16.3	23.6	32.2	5.7	3.9
Lupus	14.3	21.7	37.7	2.4	6.1
Taking other prescription medications	12.9	19.9	21.8	-4.7	-4.2
Crohns Disease (2012)	12.8	20.6	30.0	5.5	3.3
Myopia	11.5	16.7	19.5	-3.7	-4.4
Number of self-reported non-cancer illnesses	10.8	18.8	23.5	-3.8	-4.8
Supplements: Vitamin C	10.4	12.3	13.7	-3.7	-3.3
Medication: Seretide 50 evohaler	10.2	11.8	13.1	-3.6	-3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.5	17.9	22.1	3.7	4.7
Mouth/teeth dental problems: Mouth ulcers	8.2	13.0	23.3	4.8	1.6
Chest pain or discomfort	7.8	11.3	12.7	-3.1	-3.6
Gout (self-reported)	7.4	10.2	10.6	3.3	3.1
Emphysema/chronic bronchitis	7.0	7.9	12.2	-3.5	-1.9
Ever depressed for a whole week	7.0	8.6	12.2	-2.2	-3.5
Mouth/teeth dental problems: Dentures	6.8	11.5	14.0	-3.7	-3.0
Rheumatoid Arthritis	6.5	9.0	9.7	2.9	3.1
Wears glasses or contact lenses	6.0	6.9	9.9	3.1	2.0
Average weekly red wine intake	5.7	8.4	11.1	2.4	3.3
Blood Eosinophil Count	5.6	43.4	83.5	-1.8	-9.1
Miserableness	5.5	9.5	11.8	-2.7	-3.4
Lung FEV1/FVC ratio	5.0	25.5	37.1	6.1	3.7
Ever had bowel cancer screening	5.0	5.9	10.9	3.3	0.9
Heart disease (mother)	4.7	5.7	9.1	-1.5	-3.0
Schizophrenia vs Biploar Disorder	4.5	5.9	7.9	2.0	2.8
Father’s age at death	4.4	5.8	6.8	2.6	2.2
Basal cell carcinoma (self-reported)	4.4	5.2	5.6	-2.4	-2.2
Heart attack/myocardial infarction (self-reported)	4.4	5.7	7.0	-2.1	-2.6
Bipolar Disorder (2018)	4.2	6.6	7.8	-2.3	-2.8
Number of treatments/medications taken	4.2	7.6	8.0	-2.8	-2.7
Shortness of breath walking on level ground	4.2	5.0	7.2	-1.7	-2.7
Heart attack	4.0	5.2	6.7	-1.9	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	4.0	4.7	5.2	2.0	2.3
Qualifications: College or University degree	4.0	12.8	14.4	3.3	3.8
Medication: Allopurinol	3.9	5.2	6.5	2.0	2.5
Hypothyroidism (self reported)	3.8	8.8	14.4	-1.8	-3.8
Alcohol intake frequency.	3.7	8.6	8.9	-2.9	-3.0
Family relationship satisfaction	3.7	4.5	5.0	-2.2	-2.0
Alcohol usually taken with meals	3.6	5.8	6.9	2.6	2.2
Qualifications: None of the above	3.6	7.7	8.9	-2.6	-3.0
Hypothyroidism/myxoedema (self-reported)	3.6	7.0	10.4	-1.9	-3.2
Ever smoked	3.5	6.1	8.4	-1.9	-2.9
Medication: Levothyroxine sodium	3.3	5.5	8.1	-1.7	-2.8
Bipolar Disorder or Schizophrenia	3.2	7.8	9.7	-3.1	-2.4
Long-standing illness, disability or infirmity	3.0	4.5	5.4	-1.9	-2.3
Friendships satisfaction	3.0	3.7	4.0	-2.0	-1.8
Eye problems/disorders: None of the above	2.9	3.3	4.6	-2.1	-1.4
Depressed Affect (Nagel 2018)	2.8	5.8	9.1	-1.6	-3.0
Mother’s age at death	2.8	3.5	6.2	0.9	2.5
Impedance of arm (right)	2.7	12.6	13.6	-3.4	-3.7
Number of live births	2.7	3.8	3.9	-2.0	-1.9
Major Depression (MDD)	2.6	3.2	4.7	-2.2	-1.3
Bipolar Disorder (2011)	2.6	2.6	4.4	-2.1	-0.8
Falls in the last year	2.6	3.5	4.1	2.0	1.7
Impedance of arm (left)	2.6	12.1	12.9	-3.4	-3.6
Medication: Lisinopril	2.6	3.3	4.6	1.4	2.1
Hand grip strength (right)	2.5	6.8	11.0	-3.3	-1.6
Current tobacco smoking	2.5	4.1	4.3	-2.0	-2.1
Smoking status: Current	2.4	3.9	4.3	-2.1	-1.8
Smoking Status	2.3	5.5	8.1	-1.7	-2.8
Lung FVC	2.3	11.5	17.6	2.3	4.2
Frequency of depressed mood in last 2 weeks	2.2	3.1	4.9	-1.1	-2.2
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	4.6	-0.9	-2.2
Number of full sisters	2.2	2.7	2.7	-1.6	-1.7
Chronic bronchitis/emphysema (father)	2.1	2.5	2.5	-1.6	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	3.0	-1.6	-1.7
Past tobacco smoking	2.0	3.6	5.5	1.3	2.3
Exposure to tobacco smoke outside home	2.0	2.6	3.0	-1.5	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	3.6	-1.0	-1.9
Blood Platelet Count	1.9	21.5	24.8	4.3	5.0
Vitamin and mineral supplements	1.9	2.6	3.0	1.7	1.5
Diabetes (father)	1.9	2.4	2.9	-1.3	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	4.6	2.1	2.0
Pulse rate, automated reading	1.9	6.1	9.5	-3.1	-1.6
Alzheimer’s Disease (in father)	1.8	2.0	2.5	-1.2	-1.6
Birth weight of first child	1.8	3.2	4.5	-2.1	-1.4
Blood Red Count	1.7	16.6	30.1	-1.7	-5.5
Townsend deprivation index at recruitment	1.7	2.4	2.7	-1.4	-1.6
Financial situation satisfaction	1.7	2.1	2.2	-1.5	-1.4
Pain all over the body in last month	1.6	1.8	2.4	-1.0	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.5	-1.6	-1.1
Type 2 Diabetes (T2D) (2018)	1.5	2.8	3.6	-1.4	-1.9
Hand grip strength (left)	1.5	4.0	5.9	-2.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	3.8	-1.6	-1.9
Commuting to job workplace: Cycle	1.5	1.9	3.2	1.8	0.7
Mean Putamen Volume	1.4	1.6	2.4	-1.6	-0.9
Type 2 Diabetes (T2D) (2012)	1.4	1.6	1.8	-1.2	-1.3
Pack years adult smoking proportion	1.4	2.1	3.6	-1.9	-0.8
Health satisfaction	1.4	1.8	2.8	-0.9	-1.7
Hearing aid user	1.4	1.5	1.8	1.3	1.1
High cholesterol (Self-reported)	1.4	2.5	5.0	0.2	-2.2
Schizophrenia (2018)	1.3	2.7	4.6	-2.2	-0.9
Pulse wave Arterial Stiffness index	1.3	1.5	1.8	-1.1	-1.3
Impedance of whole body	1.3	6.5	7.9	-2.2	-2.8
Fed-up feelings	1.2	2.2	4.4	-0.1	-2.1
Serious illness, injury or assault to yourself	1.2	1.5	2.2	-0.9	-1.5
Medication: Atenolol	1.2	1.5	1.8	1.1	-1.3
Hearing difficulty/problems with background noise	1.2	1.8	3.7	0.1	1.9
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	6.2	1.4	2.5
Loud music exposure frequency	1.2	1.3	2.4	0.3	-1.6
Neck or shoulder pain in last month	1.2	1.6	2.8	0.7	-1.7
Alcohol drinker status: Never	1.2	1.4	1.5	-1.1	-1.2
Alzheimer’s Disease (in mother)	1.1	1.3	2.2	1.5	0.7
Triglycerides	1.1	1.8	1.8	-1.3	-1.3
Number of incorrect matches in round	1.1	1.9	3.1	-1.8	-0.8
Financial difficulties in last 2 years	1.1	1.5	2.6	-0.6	-1.6
Medication: Simvastatin	1.1	1.6	1.7	-1.3	-1.2
Time employed in main current job	1.1	1.3	1.4	1.1	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	4.2	1.6	2.1
Medication: Aspirin	1.1	1.4	1.8	-1.0	-1.4
Medication: Aspirin	1.1	1.5	1.7	-1.1	-1.3
Illnesses of father: High blood pressure	1.1	1.4	1.5	1.2	1.1
Age started oral contraceptive pill	1.1	1.3	1.4	1.1	1.2
Age at First Birth	1.0	1.5	2.8	-0.5	1.7
Body Mass Index (BMI) (2010)	1.0	1.4	2.8	1.7	0.1
Medication: Co-codamol	1.0	1.2	2.2	1.5	0.4
Fluid intelligence score	1.0	2.2	3.1	1.1	1.8
Illnesses of mother	1.0	1.3	2.6	0.0	1.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.7	1.0	1.3
Pulse wave peak to peak time	1.0	1.2	1.6	0.9	1.3
Illnesses of father: Heart disease	1.0	1.4	1.7	-1.1	-1.3
Diabetes diagnosed by doctor	1.0	1.6	1.8	-1.2	-1.3
Depression (Nagel 2018)	0.9	1.3	2.4	-0.5	-1.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.3	1.2	0.8
Severe depression (siblings)	0.9	1.1	1.1	-1.0	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	2.5	1.6	1.2
Happiness	0.9	1.1	1.7	-0.8	-1.3
Depression (self-reported)	0.9	1.0	1.2	-0.9	-1.1
Lung cancer (father)	0.9	1.1	1.9	-0.5	1.4
Breastfed as a baby	0.9	1.1	1.4	-0.9	-1.2
Blood clot in the leg (DVT)	0.9	1.1	1.4	-0.9	-1.2
Number of full brothers	0.9	1.2	1.2	-1.1	-1.1
Medication: Ibuprofen	0.9	1.0	1.8	-0.5	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.3	-1.1	-0.9
Qualifications: nursing, teaching	0.9	1.4	1.5	1.1	1.2
Commuting to job workplace: Public transport	0.9	1.1	1.5	0.9	1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.9	-0.6	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.5	-0.9	-1.2
Medication: Metformin	0.8	1.2	1.7	-0.8	-1.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.8	-0.0	1.7
Overall health rating	0.8	1.8	3.5	-0.4	-1.9
Leg pain on walking	0.8	1.0	1.9	-0.1	-1.4
Mood swings	0.8	1.4	2.5	-0.6	-1.6
Illnesses of father: None of the above (group 1)	0.8	1.0	1.1	1.0	0.9
Medication: Paracetamol	0.8	1.2	2.1	-0.5	1.4
Heart disease (siblings)	0.8	1.0	1.9	0.2	-1.4
Pack years of smoking	0.8	1.2	2.2	-1.5	-0.5
Worry (Nagel 2018)	0.7	1.4	2.0	1.4	0.9
Ovarian Cancer	0.7	1.0	1.9	-1.4	0.3
Impedance of leg (right)	0.7	3.5	5.7	-1.2	-2.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.4	1.2	0.1
Nervous feelings	0.7	1.3	2.1	0.7	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.1	1.1	0.7
Prospective memory result	0.7	0.9	1.7	-0.2	-1.3
Hair/balding pattern: Pattern 4	0.7	1.8	3.5	0.2	-1.9
Headache pain in last month	0.7	1.2	2.0	-0.6	-1.4
Had major operations	0.7	0.8	1.5	-1.2	-0.4
Osteoarthritis (self-reported)	0.7	0.9	0.9	1.0	0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.0	1.0	0.8
Pain experienced in last month	0.7	1.1	1.8	-1.4	0.7
Fasting Glucose	0.6	0.8	1.2	-0.6	-1.1
Angina	0.6	0.8	1.0	1.0	-0.8
Relative age voice broke	0.6	0.9	1.5	-1.2	-0.6
Multivitamins +/- minerals	0.6	0.8	0.9	-0.9	-0.8
Had menopause	0.6	0.8	0.9	-0.8	-0.9
Medication: Ramipril	0.6	0.8	1.5	0.1	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.9	-0.2	-1.4
Medication: Cholesterol lowering	0.6	0.9	1.7	0.1	-1.3
Tense / ‘highly strung’	0.6	1.0	1.8	1.3	0.5
Birth weight	0.6	1.3	1.8	-1.3	-0.9
Comparative body size at age 10	0.6	1.7	2.3	1.0	1.5
Medication for pain relief, constipation, heartburn	0.6	0.9	1.4	1.2	0.7
Comparative height size at age 10	0.6	3.2	4.9	-2.2	-1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.0	-1.0	0.7
Osteoporosis (self-reported)	0.6	0.7	0.8	0.9	0.8
Guilty feelings	0.6	0.8	1.6	-1.3	0.2
Medication: Atorvastatin	0.6	0.7	1.4	1.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	0.8	-0.9	-0.8
Supplements: Calcium	0.6	0.7	1.3	0.3	1.1
Reaction Time	0.5	0.9	1.3	-0.7	-1.1
Schizophrenia (2014)	0.5	1.1	2.2	-1.5	-0.1
Height	0.5	10.4	20.4	-4.5	-0.5
Cardiovascular Disease	0.5	1.8	2.5	1.0	-1.6
Hearing difficulty/problems: Yes	0.5	0.8	1.3	-0.5	1.1
Maternal smoking around birth	0.5	0.7	1.4	-1.2	0.0
Diabetes (self-reported)	0.5	0.8	0.9	-0.9	-0.9
Worrier / anxious feelings	0.5	1.0	1.8	-0.4	-1.3
Hair/balding pattern: Pattern 3	0.5	0.7	0.8	-0.8	-0.9
Noisy workplace	0.5	0.7	1.3	0.0	-1.1
Medication: Lansoprazole	0.5	0.6	0.9	-0.9	0.5
Medication: Paracetamol	0.5	0.8	1.5	-1.2	0.2
Number of children fathered	0.5	0.6	1.0	-0.4	-1.0
Angina (self-reported)	0.5	0.6	0.6	0.8	-0.8
Arm predicted mass (right)	0.5	2.4	3.7	1.0	1.9
Suffer from ‘nerves’	0.5	0.8	1.1	0.8	1.0
Knee pain experienced in last month	0.5	0.8	1.4	1.2	-0.5
Hypertension (Self-reported)	0.5	1.4	2.7	0.3	-1.6
Smoking status: Previous	0.5	0.8	1.6	0.1	-1.2
Eye problems/disorders: Cataract	0.5	0.6	1.2	1.1	-0.1
Irritability	0.5	0.8	1.2	1.1	0.6
Neuroticism (Nagel 2018)	0.4	0.8	1.5	-0.3	-1.2
Verbal and Numeric Reasoning (VNR)	0.4	1.1	1.2	1.0	1.1
Prostate Cancer	0.4	0.5	0.8	0.5	-0.9
Neuroticism (2016)	0.4	0.5	1.0	-0.2	-1.0
Heel T-Score	0.4	3.1	3.7	1.9	1.6
Average weekly spirits intake	0.4	0.5	0.8	-0.9	-0.4
Diabetes (mother)	0.4	0.5	0.9	0.3	0.9
Average weekly fortified wine intake	0.4	0.5	0.5	-0.6	0.7
Arm fat percentage (right)	0.4	1.5	2.1	-1.0	-1.4
Alcohol intake versus 10 years previously	0.4	0.7	1.2	0.3	1.1
Exposure to tobacco smoke at home	0.4	0.5	0.7	-0.8	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	-0.9	-0.4
Arm fat-free mass (right)	0.4	1.8	2.9	0.9	1.7
Medication: Blood pressure	0.4	0.7	1.3	0.3	-1.2
Arm fat percentage (left)	0.4	1.5	2.0	-1.0	-1.4
Loneliness, isolation	0.4	0.6	1.1	-0.2	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	-0.4	0.8
Average weekly champagne plus white wine intake	0.4	0.6	0.6	0.8	0.7
Number of operations (self-reported)	0.4	0.7	1.2	-0.3	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	1.8	-0.6	1.4
Cholesterol lowering medication	0.4	0.6	0.9	-0.9	-0.6
Intelligence (Savage-Jansen 2018)	0.3	1.1	1.6	0.7	1.3
Breast Cancer	0.3	0.7	1.3	-1.1	0.2
Waist Hip Ratio (WHR)	0.3	1.3	2.0	0.8	1.4
Neuroticism	0.3	0.6	1.2	-0.2	-1.1
Chronotype (morning person)	0.3	0.7	1.0	0.6	1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.7	-0.0	-0.8
Trunk fat percentage	0.3	1.0	1.3	-0.8	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.0	-0.9
High blood pressure	0.3	0.9	1.2	0.8	-1.1
Stomach or abdominal pain in last month	0.3	0.4	0.4	-0.6	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	0.9	0.3
Forced vital capacity (FVC)	0.3	1.1	2.1	-0.3	1.4
Pulse rate	0.3	0.5	0.6	-0.8	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	-0.9	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.2	-1.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	-0.8	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.4	-0.8
Medication: Bendroflumethiazide	0.3	0.4	0.7	0.4	-0.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	0.4	-0.7
Fractured/broken bones in last 5 years	0.3	0.4	0.4	0.5	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.7	-0.0
HbA1C	0.2	0.3	0.3	0.6	0.4
Tanning	0.2	2.0	2.8	-1.7	-1.1
Relative age of first facial hair	0.2	0.4	0.5	-0.7	-0.4
Supplements: Zinc	0.2	0.2	0.2	-0.5	-0.5
Age when periods started (menarche)	0.2	0.5	0.9	-1.0	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.0	0.7
Qualifications: CSEs or equivalent	0.2	0.3	0.6	-0.0	-0.8
High blood pressure (mother)	0.2	0.3	0.4	0.3	-0.6
Impedance of leg (left)	0.2	1.2	2.1	-0.6	-1.4
Illnesses of siblings	0.2	0.3	0.5	0.1	0.7
Neuroticism score	0.2	0.4	0.8	-0.1	-0.9
Standing height	0.2	1.7	3.4	-1.8	-0.2
Worry too long after embarrassment	0.2	0.3	0.6	-0.1	0.8
Age at first live birth	0.2	0.3	0.4	-0.7	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	-0.6	-0.3
Migraine (self-reported)	0.2	0.2	0.3	0.5	-0.5
Mean time to correctly identify matches	0.2	0.5	0.9	0.1	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.2	-0.5	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.4	-0.6
Back pain experienced in last month	0.2	0.3	0.5	0.7	-0.4
Breast cancer (self-reported)	0.2	0.3	0.3	0.6	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.3	-0.6	-0.5
Diastolic blood pressure, automated reading	0.2	0.6	0.6	0.8	0.7
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.6	-0.2
Arm predicted mass (left)	0.2	0.8	1.5	0.3	1.2
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.3	0.2
BMI	0.1	0.5	0.7	0.4	0.9
Systolic Blood Pressure	0.1	0.4	0.6	-0.5	-0.8
Hair Pigment	0.1	3.8	5.4	-2.3	1.5
Sensitivity / hurt feelings	0.1	0.2	0.3	0.3	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.2	0.4	-0.4
Systolic blood pressure, automated reading	0.1	0.2	0.2	0.4	0.5
Medication for hormone replacement therapy	0.1	0.2	0.3	-0.6	0.1
Leg fat-free mass (left)	0.1	0.4	0.8	-0.9	0.2
Supplements: Glucosamine	0.1	0.1	0.1	-0.3	-0.3
Sitting height	0.1	0.4	0.7	-0.3	0.8
Leg predicted mass (left)	0.1	0.4	0.7	-0.8	0.3
Trunk fat mass	0.1	0.5	0.5	-0.6	-0.7
Waist circumference	0.1	0.2	0.3	0.6	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	0.1
Mouth/teeth dental problems	0.1	0.2	0.4	-0.7	0.1
Trunk fat-free mass	0.1	0.4	0.9	-0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	-0.7	0.1
Arm fat mass (right)	0.1	0.3	0.4	-0.4	-0.6
Trunk predicted mass	0.1	0.5	0.9	-0.0	0.9
Length of working week for main job	0.1	0.1	0.1	-0.3	-0.2
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.6	0.1
Pulse wave reflection index	0.1	0.1	0.3	-0.5	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	0.3	-0.5
Glaucoma (self-reported)	0.1	0.1	0.1	0.0	-0.4
Medication: Amlodipine	0.1	0.2	0.3	0.5	0.1
High blood pressure (siblings)	0.1	0.1	0.2	0.1	0.5
Forced vital capacity (FVC), Best measure	0.1	0.5	0.7	-0.4	0.9
Body fat percentage	0.1	0.6	0.8	-0.6	-0.9
Leg fat percentage (right)	0.1	0.4	0.7	0.2	-0.8
Medication: Omeprazole	0.1	0.2	0.3	-0.6	-0.1
Age at last live birth	0.1	0.1	0.2	-0.4	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.1	-0.5
Whole body fat-free mass	0.1	0.5	0.9	-0.2	0.9
Leg fat-free mass (right)	0.1	0.5	0.8	-0.5	0.9
Medication for cholesterol	0.1	0.1	0.2	-0.4	-0.1
Mineral and other dietary supplements	0.1	0.2	0.2	-0.4	0.5
Whole body water mass	0.1	0.6	1.1	-0.1	1.1
Leg predicted mass (right)	0.1	0.6	1.0	-0.4	1.0
Arm fat mass (left)	0.1	0.3	0.5	-0.4	-0.7
Medication: Blood pressure	0.1	0.2	0.3	0.3	-0.5
Leg fat percentage (left)	0.1	0.2	0.3	0.6	-0.3
Arm fat-free mass (left)	0.1	0.6	1.1	0.4	1.1
Average weekly beer plus cider intake	0.1	0.2	0.4	0.6	0.1
Risk taking	0.1	0.2	0.4	0.6	0.1
LDL Cholesterol	0.0	0.0	0.0	-0.1	0.1
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	0.1	-0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.3	0.0
Body mass index (BMI)	0.0	0.1	0.2	0.4	0.0
Had other major operations	0.0	0.0	0.0	-0.2	-0.0
Weight	0.0	0.1	0.2	-0.4	-0.1
Hip circumference	0.0	0.1	0.2	0.4	-0.2
Whole body fat mass	0.0	0.2	0.2	-0.4	-0.5
Leg fat mass (right)	0.0	0.1	0.1	-0.2	-0.3
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.1	0.0
Medication: Gliclazide	0.0	0.0	0.1	0.1	0.2
Ever taken oral contraceptive pill	0.0	0.0	0.0	0.2	-0.1
Eye problems/disorders: Glaucoma	0.0	0.1	0.1	0.3	0.2
Basal metabolic rate	0.0	0.2	0.3	-0.3	0.6
Unable to work because of sickness or disability	0.0	0.0	0.0	0.1	-0.1
Leg fat mass (left)	0.0	0.0	0.0	0.1	-0.1

Hub : Genes

IKZF3

Models

Trait associations