TWAS
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Models
Genes
Traits
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Traits
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Gout (self-reported)
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chr12:56,776,586-58,705,075
Best TWAS P=4.62e-13 · Best GWAS P=1.2e-14 conditioned to 0.00738
57M
57.5M
58M
58.5M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
INHBC
0.03
0.03
lasso
3
0.02
0.0016
-7.5
7.2
4.6e-13
-0.94
0.00
0.98
TRUE
3
GTEx
Skin Not Sun Exposed Suprapubic
KIF5A
0.13
0.00
enet
9
0.03
0.0067
-7.7
-7.1
1.7e-12
0.88
0.01
0.98
FALSE
2
GTEx
Esophagus Mucosa
ARHGEF25
0.06
0.01
lasso
6
0.01
0.0612
-7.6
-6.0
1.7e-09
0.84
0.02
0.82
FALSE
1
GTEx
Breast Mammary Tissue (Male)
TMEM194A
0.16
0.05
lasso
6
0.09
0.0052
-7.2
-5.7
1.2e-08
0.71
0.02
0.69
FALSE